keyword
MENU ▼
Read by QxMD icon Read
search

inconclusive

keyword
https://www.readbyqxmd.com/read/28551711/why-are-most-phospholipidosis-inducers-also-herg-blockers
#1
Svetoslav Slavov, Iva Stoyanova-Slavova, Shuaizhang Li, Jinghua Zhao, Ruili Huang, Menghang Xia, Richard Beger
Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken with data sets comprised of 4096 compounds assayed for hERG inhibition and 5490 compounds assayed for PLD induction. To eliminate the chemical domain effect, a filtered data set of 567 compounds tested in quantitative high-throughput screening (qHTS) format for both hERG inhibition and PLD induction was constructed...
May 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28551461/revisiting-the-value-of-competition-assays-in-folate-receptor-mediated-drug-delivery
#2
Steven K Jones, Anwesha Sarkar, Daniel P Feldmann, Peter Hoffmann, Olivia M Merkel
Polymeric nanoparticles have been studied for gene and drug delivery. These nanoparticles can be modified to utilize a targeted delivery approach to selectively deliver their payload to specific cells, while avoiding unwanted delivery to healthy cells. One commonly over-expressed receptor which can be targeted by ligand-conjugated nanoparticles is the folate receptor alpha (FRα). The ability to target FRα remains a promising concept, and therefore, understanding the binding dynamics of the receptor with the ligand of the nanoparticle therapeutic can provide valuable insight...
May 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28549872/facial-thread-lifting-with-suture-suspension
#3
Joana de Pinho Tavares, Carlos Augusto Costa Pires Oliveira, Rodolfo Prado Torres, Fayez Bahmad Junior
INTRODUCTION: The increased interest in minimally-invasive treatments, such as the thread lifting, with lower risk of complications, minimum length of time away from work and effectiveness in correcting ptosis and aging characteristics has led many specialists to adopt this technique, but many doubts about its safety and effectiveness still limit its overall use. OBJECTIVE: To analyze data published in the literature on the durability of results, their effectiveness, safety, and risk of serious adverse events associated with procedures using several types of threading sutures...
May 9, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28549846/physical-activity-and-age-related-macular-degeneration-a-systematic-literature-review-and-meta-analysis
#4
Myra B McGuinness, Jerome Le, Paul Mitchell, Bamini Gopinath, Ester Cerin, Nicole T M Saksens, Tina Schick, Carel B Hoyng, Robyn H Guymer, Robert P Finger
PURPOSE: Age-related macular degeneration (AMD) is the main cause of irreversible severe vision loss in developed countries. It has been suggested that a healthy lifestyle may assist in delaying the onset and progression of AMD, however evidence for an association between physical activity and age-related macular degeneration (AMD) remains inconclusive. DESIGN: Systematic review and meta-analysis METHODS: Medline, EMBASE and Google Scholar were systematically searched for studies up to May 2015...
May 23, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28549037/evaluation-of-a-dna-extraction-and-purification-protocol-using-archived-formalin-fixed-paraffin-embedded-tissues-for-braf-mutations-analysis-in-papillary-thyroid-microcarcinomas
#5
Adela Nechifor-Boilă, Andrada Loghin, Françoise Descotes, Myriam Decaussin-Petrucci, Angela Borda
The isolation of good quality genomic DNA from formalin-fixed, paraffin-embedded tissues is challenging, especially in cases of small tissue specimens. The aim of our study was to evaluate a DNA extraction protocol using formalin-fixed, paraffin-embedded tissues in our laboratory and apply this method to a series of papillary thyroid microcarcinomas (PTMCs). A total of 25 PTMCs and 3 papillary thyroid carcinoma control cases were included in the study. We assessed a DNA extraction protocol on the basis of a precipitation method (MasterPure DNA purification kit, Epicentre), according to the manufacturer's instructions...
May 25, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28548878/immunophenotyping-of-the-cerebrospinal-fluid-as-a-prognostic-factor-at-diagnosis-of-acute-lymphoblastic-leukemia-in-children-and-adolescents
#6
Camila Silva Peres Cancela, Mitiko Murao, Juliana Godoy Assumpção, Marcelo Eduardo de Lima Souza, Antonio Vaz de Macedo, Marcos Borato Viana, Benigna Maria De Oliveira
This study aimed at evaluating the use of immunophenotyping (IMP) in the identification of blast cells in the cerebrospinal fluid (CSF) of children and adolescents with acute lymphoblastic leukemia (ALL). Sixty-seven patients aged 18 years or younger were included. Fifty-five CSF samples were analyzed at initial diagnosis and 17 at the time of relapse. A cytological analysis (CA) was performed in all 72 samples, while IMP was done in 63. Blasts were identified in only three samples by CA, whereas all three samples were found negative by IMP, one of which had no isolation of nucleated cells after centrifugation...
May 26, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28548298/total-cerebral-small-vessel-disease-score-and-cognitive-performance-in-community-dwelling-older-adults-results-from-the-atahualpa-project
#7
Victor J Del Brutto, Jorge G Ortiz, Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, José Biller
OBJECTIVE: Cerebral small vessel disease (SVD) is inversely associated with cognitive performance. However, whether the total SVD score is a better predictor of poor cognitive performance than individual signatures of SVD is inconclusive. We aimed to estimate the combined and independent predictive power of these MRI findings. METHODS: Atahualpa residents aged ≥60 years underwent brain MRI. Cognitive performance was measured by the Montreal Cognitive Assessment (MoCA)...
May 26, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28547937/lack-of-association-of-the-fat-mass-and-obesity-associated-fto-gene-rs9939609-polymorphism-with-breast-cancer-risk-a-systematic-review-and-meta-analysis-based-on-case-control-studies
#8
Jamal Jafari Nedooshan, Saeed Kargar, Hossein Neamatzadeh, Fatemeh Haghighi, Reihaneh Dehghani Mohammad Abadi, Niloofar Seddighi
Background: Previously published data on any association of the fat mass and obesity-associated (FTO) gene with breast cancer risk remain inconclusive. Therefore, we conducted the present meta-analysis of links between breast cancer and the FTO rs9939609 polymorphism. Methods: We have conducted a systematic review of the English literature by searching PubMed, Google Scholar and ISI Web of Knowledge databases for studies on associations between the FTO rs9939609 polymorphism and breast cancer risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association using fixed- or random-effects model...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28546635/local-cryotherapy-minimally-impacts-the-metabolome-and-transcriptome-of-human-skeletal-muscle
#9
Dylan C Sarver, Kristoffer B Sugg, Nathaniel P Disser, Elizabeth R Sibilsky Enselman, Tariq M Awan, Christopher L Mendias
Cryotherapy is commonly used in the treatment of skeletal muscle injuries. However, the data to support the use of cryotherapy is inconclusive, and the biochemical etiology of cryotherapy in human skeletal muscle remains largely unknown. We therefore sought to determine how a clinically-relevant dose of cryotherapy would impact the transcriptome and metabolome of skeletal muscle. Eight healthy male subjects (age 24.7 ± 4.5 years, BMI 22.2 ± 1.6) received a 15 minute bout of local cryotherapy, delivered via ice cup massage over the anterolateral thigh...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545916/long-term-success-and-failure-with-sg-is-predictable-by-3-months-a-multivariate-model-using-simple-office-markers
#10
Austin Cottam, Josiah Billing, Daniel Cottam, Peter Billing, Samuel Cottam, Hinali Zaveri, Amit Surve
INTRODUCTION: Despite being the most common surgery in the United States, little is known about predicting weight loss success and failure with sleeve gastrectomy (SG). Papers that have been published are inconclusive. We decided to use multivariate analysis from 2 practices to design a model to predict weight loss outcomes using data widely available to any surgical practice at 3 months to determine weight loss outcomes at 1 year. SETTING: Two private practices in the United States...
March 23, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28545497/mortality-by-country-of-birth-in-the-nordic-countries-a-systematic-review-of-the-literature
#11
Helena Honkaniemi, Jennie Bacchus-Hertzman, Johan Fritzell, Mikael Rostila
BACKGROUND: Immigration to the Nordic countries has increased in the last decades and foreign-born inhabitants now constitute a considerable part of the region's population. Several studies suggest poorer self-reported health among foreign-born compared to natives, while results on mortality and life expectancy are inconclusive. To date, few studies have summarized knowledge on mortality differentials by country of birth. This article aims to systematically review previous results on all-cause and cause-specific mortality by country of birth in the Nordic countries...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28544999/mercury-bioaccumulation-in-offshore-reef-fishes-from-waters-of-the-southeastern-usa
#12
Wiley Sinkus, Virginia Shervette, Joseph Ballenger, Lou Ann Reed, Craig Plante, Byron White
Mercury (Hg) concentrations and nitrogen (δ(15)N) and carbon (δ(13)C) stable isotopic ratios were measured to assess differences in Hg bioaccumulation in four predatory fish species (Mycteroperca microlepis, Lutjanus campechanus, Caulolatilus microps, and Serioli dumerili) of high commercial and recreational importance in Atlantic waters of the southeastern US. Positive relationships existed between Hg and length, weight, and age, for all species, strongest for M. microlepis and L. campechanus. Intraspecific Hg concentrations also strongly correlated with δ(15)N for all species, and δ(13)C for only L...
May 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28543791/the-association-between-eccentric-hip-abduction-strength-and-hip-and-knee-angular-movements-in-recreational-male-runners-an-explorative-study
#13
René B K Brund, Sten Rasmussen, Rasmus O Nielsen, Uwe G Kersting, Uffe Laessoe, Michael Voigt
Weak hip abductors may be related with increased hip adduction and knee abduction angular movement, which may be risk factors of lower extremity injuries. Since the role of eccentric hip abduction strength (EHAS) on hip adduction angular movement and the knee abduction angular movement (KABD) remains unclear and the purpose of the present study was to explore the association between EHAS and hip- and knee angular movement. In 100 healthy male recreational runners, EHAS was quantified using an isokinetic dynamometer, while hip- and knee angular movement were collected using pressure sensitive treadmill and Codamotion active marker system...
May 24, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28542675/analgesic-effects-of-intravenous-acetaminophen-vs-placebo-for-endoscopic-sinus-surgery-and-postoperative-pain-a-randomized-clinical-trial
#14
Matthew A Tyler, Kent Lam, Faramarz Ashoori, Chunyan Cai, Joshua J Kain, Samer Fakhri, Martin J Citardi, Davide Cattano, Amber Luong
Importance: Intravenous acetaminophen is a commonly prescribed analgesic for the prevention and treatment of postsurgical pain. Its efficacy in the context of endoscopic sinus surgery (ESS) has yielded mixed results. Objective: To compare the efficacy of perioperative intravenous acetaminophen (IVAPAP) with that of placebo in improving early postoperative pain after endoscopic sinus surgery (ESS). Design, Setting, and Participants: A prospective, randomized clinical trial including 62 patients undergoing ESS for chronic rhinosinusitis in a single tertiary referral hospital...
May 25, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28542667/-ign-complementary-alternative-medicine-in-adolescents-with-attention-deficit-hyperactivity-disorder-and-mood-disorders
#15
María Pilar Pérez Carmona
The Complementary/Alternative Medicine (CAM) have been increasingly used by patients such as children and adolescents. The Ministry of Health in Chile (MINSAL) has recognized and regulated some CAM, although there is still unknown their effectiveness and safety of these. OBJECTIVE: Review the available evidence regarding the use of CAM in adolescents with the attention deficit hyperactivity syndrome (ADHD) and mood disorders. METHODOLOGY: A review of the related literature about this topic on PubMed, focus on the last 10 years and using as a keywords Complementary/Alternative Medicine/Therapies, Attention deficit disorder with hyperactivity, Mood disorders, and Children/Adolescents...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542413/association-of-drinking-pattern-with-risk-of-coronary-heart-disease-incidence-in-the-middle-aged-and-older-chinese-men-results-from-the-dongfeng-tongji-cohort
#16
Yizhi Zhang, Yanqiu Yu, Yu Yuan, Kuai Yu, Handong Yang, Xiulou Li, Xinwen Min, Ce Zhang, Meian He, Xiaomin Zhang, Tangchun Wu
BACKGROUND: Epidemiologic studies have found that moderate alcohol consumption was associated with a decreased risk of coronary heart disease (CHD) incidence. Nevertheless, whether the drinking pattern is associated with CHD incidence still remains inconclusive. METHODS: We included 8,469 Chinese men aged 45-81 years, who were free of CHD, stroke, or cancer at baseline from Dongfeng-Tongji cohort. A semi-structured questionnaire was used to collect information on alcohol consumption and other covariates...
2017: PloS One
https://www.readbyqxmd.com/read/28542337/changes-in-hospitalizations-for-chronic-respiratory-diseases-after-two-successive-smoking-bans-in-spain
#17
Iñaki Galán, Lorena Simón, Elena Boldo, Cristina Ortiz, Rafael Fernández-Cuenca, Cristina Linares, María José Medrano, Roberto Pastor-Barriuso
BACKGROUND: Existing evidence on the effects of smoke-free policies on respiratory diseases is scarce and inconclusive. Spain enacted two consecutive smoke-free regulations: a partial ban in 2006 and a comprehensive ban in 2011. We estimated their impact on hospital admissions via emergency departments for chronic obstructive pulmonary disease (COPD) and asthma. METHODS: Data for COPD (ICD-9 490-492, 494-496) came from 2003-2012 hospital admission records from the fourteen largest provinces of Spain and from five provinces for asthma (ICD-9 493)...
2017: PloS One
https://www.readbyqxmd.com/read/28541086/buffering-and-direct-effect-of-posttraumatic-growth-in-predicting-distress-following-cancer
#18
Ashley Wei-Ting Wang, Cheng-Shyong Chang, Shou-Tung Chen, Dar-Ren Chen, Fang Fan, Charles S Carver, Wen-Yau Hsu
OBJECTIVE: Evidence regarding post traumatic growth (PTG) as a predictor of future reductions in distress has been inconclusive. The purpose of this study was to examine this relationship in a multiple-observation prospective study, to provide a more rigorous test of prediction over time. This longitudinal study extended previous work by taking into account perceptions of vulnerability and explored the buffering role of PTG on the links between vulnerability and psychological distress...
June 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28540977/oral-contraceptive-pill-progestogen-or-oestrogen-pretreatment-for-ovarian-stimulation-protocols-for-women-undergoing-assisted-reproductive-techniques
#19
REVIEW
Cindy Farquhar, Luk Rombauts, Jan Am Kremer, Anne Lethaby, Reuben Olugbenga Ayeleke
BACKGROUND: Among subfertile women undergoing assisted reproductive technology (ART), hormone pills given before ovarian stimulation may improve outcomes. OBJECTIVES: To determine whether pretreatment with the combined oral contraceptive pill (COCP) or with a progestogen or oestrogen alone in ovarian stimulation protocols affects outcomes in subfertile couples undergoing ART. SEARCH METHODS: We searched the following databases from inception to January 2017: Cochrane Gynaecology and Fertility Group Specialised Register, The Cochrane Central Register Studies Online, MEDLINE, Embase, CINAHL and PsycINFO...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28540211/delayed-enhancement-cardiac-computed-tomography-for-the-assessment-of-myocardial-infarction-from-bench-to-bedside
#20
REVIEW
Gaston A Rodriguez-Granillo
A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT)...
April 2017: Cardiovascular Diagnosis and Therapy
keyword
keyword
117018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"