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https://www.readbyqxmd.com/read/29223873/molecular-characterization-and-expression-profiles-of-lpxrfa-at-the-brain-pituitary-gonad-axis-of-half-smooth-tongue-sole-cynoglossus-semilaevis-during-ovarian-maturation
#1
Bin Wang, Quan Liu, Xuezhou Liu, Yongjiang Xu, Bao Shi
Gonadotropin-inhibitory hormone (GnIH) has been characterized by its ability to inhibit either basal or gonadotropin-releasing hormone (GnRH)-induced gonadotropin synthesis and release in birds and mammals. However, the physiological role of GnIH on the reproductive axis in fish remains inconclusive, with most studies focusing on the orders Cypriniformes and Perciformes. To gain insight into the role of GnIH in the regulation of reproduction in the order Pleuronectiformes, we first cloned the LPXRFa gene, the piscine ortholog of GnIH, in the half-smooth tongue sole...
December 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29221817/polyunsaturated-fatty-acids-in-plasma-at-8%C3%A2-years-and-subsequent-allergic-disease
#2
Jessica Magnusson, Sandra Ekström, Inger Kull, Niclas Håkansson, Sara Nilsson, Magnus Wickman, Erik Melén, Ulf Risérus, Anna Bergström
BACKGROUND: Polyunsaturated fatty acids (PUFAs) are hypothesized to modulate the risk of allergic disease. However, evidence from previous studies is inconclusive, and limited longitudinal data exist using circulating biomarkers of PUFA intake and metabolism. OBJECTIVE: We aimed to investigate associations between n-3 and n-6 PUFAs at age 8 years and asthma, rhinitis, and aeroallergen sensitization at age 16 years. METHODS: Proportions of n-3 PUFAs (very long-chain n-3 [VLC n-3; sum of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid] and α-linolenic acid) and n-6 PUFAs (linoleic acid and arachidonic acid [AA]) in blood samples at age 8 years were measured for 940 children from the prospective Swedish birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology)...
November 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29220304/the-interaction-between-semantic-representation-and-episodic-memory
#3
Jing Fang, Naima Rüther, Christian Bellebaum, Laurenz Wiskott, Sen Cheng
The experimental evidence on the interrelation between episodic memory and semantic memory is inconclusive. Are they independent systems, different aspects of a single system, or separate but strongly interacting systems? Here, we propose a computational role for the interaction between the semantic and episodic systems that might help resolve this debate. We hypothesize that episodic memories are represented as sequences of activation patterns. These patterns are the output of a semantic representational network that compresses the high-dimensional sensory input...
December 8, 2017: Neural Computation
https://www.readbyqxmd.com/read/29218702/deep-brain-stimulation-for-drug-resistant-epilepsy
#4
REVIEW
Michael C H Li, Mark J Cook
OBJECTIVES: To review clinical evidence on the antiepileptic effects of deep brain stimulation (DBS) for drug-resistant epilepsy, its safety, and the factors influencing individual outcomes. METHODS: A comprehensive search of the medical literature (PubMed, Medline) was conducted to identify relevant articles investigating DBS therapy for drug-resistant epilepsy. Reference lists of these articles were used to source further articles. RESULTS: Stimulation of the anterior nucleus of the thalamus (ANT) and hippocampus (HC) has been shown to decrease the frequency of refractory seizures...
December 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#5
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29217131/omega-loop-gastric-bypass-is-more-effective-for-weight-loss-but-negatively-impacts-liver-enzymes-a-registry-based-comprehensive-first-year-analysis
#6
Hadar Spivak, Yaron Munz, Moshe Rubin, Itamar Raz, Tamy Shohat, Orit Blumenfeld
BACKGROUND: The impact of omega-loop gastric bypass (OLGB) on weight loss and liver enzymes remains inconclusive. OBJECTIVE: The aim of this study was to compare the impact of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and OLGB on weight loss and liver enzyme levels. SETTING: National Bariatric Surgery Registry. METHODS: The study included 10,675 cases of SG, 1590 cases of RYGB, and 469 cases of OLGB that had available baseline and 1-year (12 ± 2 mo) follow-up data...
November 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29216833/non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-cholangiocarcinoma-a-systematic-review-and-meta-analysis
#7
Nicha Wongjarupong, Buravej Assavapongpaiboon, Paweena Susantitaphong, Wisit Cheungpasitporn, Sombat Treeprasertsuk, Rungsun Rerknimitr, Roongruedee Chaiteerakij
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recently identified as a risk factor of gastrointestinal tract cancers, especially hepatocellular carcinoma, and colorectal cancer. Whether NAFLD is a risk factor for cholangiocarcinoma (CCA) remains inconclusive. The aim of this study is to determine a potential association between NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA). METHODS: A search was conducted for relevant studies published up to April 2017 using MEDLINE, EMBASE, Scopus and Cochrane databases...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29215413/fdg-pet-ct-guided-biopsy-in-angiosarcoma-of-bone-diagnosis-staging-and-beyond
#8
Antonella Matti, Andrea Farolfi, Tommaso Frisoni, Stefano Fanti, Cristina Nanni
Primary angiosarcoma of the bone (PAB) is a particularly rare and aggressive form of malignancy in the spectrum of vascular tumours, and it accounts for less than 1% of sarcomas. This case of PAB, diagnosed thanks to FDG-PET/CT guided biopsy, is a paradigm of how powerful are clinical informations that can be derived by a F-FDG PET/CT, in view of negative or inconclusive imaging of conventional radiology, starting from the metabolic characterization of an equivocal finding, the possibility to drive the biopsy towards the most active site, the accurate total body staging, the stratification of prognosis and early therapy assessment...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29215312/gstm1-and-gstt1-gene-polymorphisms-gene-gene-interaction-and-esophageal-carcinoma-risk-evidence-from-an-updated-meta-analysis
#9
Liping Ma, Biyang Lan, Lingxiao Guo, Shaoyun Nong, Cuibo Huang, Qiulong Wu, Zhihu Huang
BACKGROUND: Published data regarding the association between GSTM1 and/or GSTT1 gene polymorphisms and esophageal cancer (EC) susceptibility remain inconclusive. To clarify these associations, a meta-analysis was conducted. METHODS: We conducted a comprehensive search in PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) for all such manuscripts published as of May 1, 2017. The pooled odds ratio (ORs) with confidence intervals (95% CI) were estimated for each study to assess the strength of the association...
December 7, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29214849/the-dimensions-of-ruminative-thinking-one-for-all-or-all-for-one
#10
Ljiljana Mihić, Zdenka Novović, Milica Lazić, David J A Dozois, Radomir Belopavlović
The Ruminative Thought Scale (RTS) was developed to measure the ruminative thinking style, presumably common to various psychopathological disorders. However, prior factor-analytic research was inconclusive regarding unidimensionality versus multidimensionality of the RTS. The present study was conducted on a large, heterogeneous Serbian sample ( N = 838). A subsample was retested 6 months later providing information about symptoms of depression and various anxiety symptoms. Results showed that a bifactor model of the RTS (representing one general and four group factors) had a better fit than the second-order and one-factor models...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/29210722/point-of-care-ultrasound-in-the-periarrest-setting-lessons-learned-a-case-report
#11
Peter Juhl-Olsen, Rasmus Aagaard, Anni Nørgaard Jeppesen
Point-of-care ultrasound may elucidate reversible causes of cardiac arrest, and its use is supported by international guidelines in the periarrest setting. We present a case in which the treatment of cardiac arrest caused tension pneumothoraces and cardiac tamponade by pneumopericardium. Both pneumothorax and tamponade were expected to be identified with ultrasound, but were not. Subcutaneous emphysema precluded the diagnosis of pneumothorax. Cardiac imaging was false negative for tamponade, because the latter was caused by air and not fluid...
November 27, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29210284/can-persistence-with-cholinesterase-inhibitor-treatment-lower-mortality-and-health-care-costs-among-patients-with-alzheimer-s-disease-a-population-based-study-in-taiwan
#12
Li-Jung Elizabeth Ku, Chung-Yi Li, Yu Sun
Although cholinesterase inhibitors (ChEIs) have been proved to help reduce cognitive deterioration in patients with Alzheimer's disease (AD), their effects on survival remain inconclusive. This study aims to assess the effects of the persistent use of ChEIs on the risk of mortality in patients with AD. This population-based cohort study included 8614 patients having AD with ChEI prescription from 2002 to 2006 and followed until 2010. Kaplan-Meier curves and hazard ratios (HRs) of mortality were estimated in association with ChEI treatment duration and adherence...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29209188/age-related-decline-of-wrist-position-sense-and-its-relationship-to-specific-physical-training
#13
Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L Keller-Ross
Perception of limb and body positions is known as proprioception. Sensory feedback, especially from proprioceptive receptors, is essential for motor control. Aging is associated with a decline in position sense at proximal joints, but there is inconclusive evidence of distal joints being equally affected by aging. In addition, there is initial evidence that physical activity attenuates age-related decline in proprioception. Our objectives were, first, to establish wrist proprioceptive acuity in a large group of seniors and compare their perception to young adults, and second, to determine if specific types of training or regular physical activity are associated with preserved wrist proprioception...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29208960/mif-173-g%C3%A2-%C3%A2-c-rs755622-gene-polymorphism-modulates-tuberculosis-risk-evidence-from-a-meta-analysis-and-trial-sequential-analysis
#14
Mohammed Y Areeshi, Raju K Mandal, Sajad A Dar, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, B N Mishra, Naseem Akhter, Shafiul Haque
The macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in inhibiting the growth of pathogenic Mycobacterium tuberculosis (M.tb) and regulates immune responses against M.tb pathogen. MIF -173 G > C gene polymorphism may affect immunity in an individual and leads to susceptibility to tuberculosis (TB). A large number of studies have investigated the relevance of this polymorphism with TB risk, but their results were inconclusive. To obtain a precise conclusion, a meta-analysis was performed by retrieving six eligible studies from Google Scholar, PubMed (Medline), and EMBASE online databases...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208940/cea-but-not-ca19-9-is-an-independent-prognostic-factor-in-patients-undergoing-resection-of-cholangiocarcinoma
#15
Sven H Loosen, Christoph Roderburg, Katja L Kauertz, Alexander Koch, Mihael Vucur, Anne T Schneider, Marcel Binnebösel, Tom F Ulmer, Georg Lurje, Wenzel Schoening, Frank Tacke, Christian Trautwein, Thomas Longerich, Cornelis H Dejong, Ulf P Neumann, Tom Luedde
Cholangiocarcinoma (CCA) represents a rare form of primary liver cancer with increasing incidence but dismal prognosis. Surgical treatment has remained the only potentially curative treatment option, but it remains unclear which patients benefit most from liver surgery, highlighting the need for new preoperative stratification strategies. In clinical routine, CA19-9 represents the most widely used tumor marker in CCA patients. However, data on the prognostic value of CA19-9 in CCA patients are limited and often inconclusive, mostly due to small cohort sizes...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208766/mir-146a-c-g-polymorphism-increased-the-risk-of-head-and-neck-cancer-but-overall-cancer-risk-a-analyses-of-89-studies
#16
Dezhong Sun, Xiaoyan Zhang, Xiaolei Zhang
Several studies have evaluated the association of miR-146a C/G with head and neck cancer (HNC) susceptibility, and overall cancer risk, but inconclusive outcomes. To drive a more precise estimation, we carried out this meta-analysis. The literature searched from Medline (Mainly PubMed), Embase, the Cochrane Library and Google Scholar databases to identify eligible studies. A total of 89 studies were included. The results showed that miR-146a C/G was significantly associated with increased head and neck cancer risk in dominant model ( I2 = 15...
December 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29207693/serum-uric-acid-in-chronic-obstructive-pulmonary-disease-a-hospital-based-case-control-study
#17
Rajlaxmi Sarangi, Nirupama Varadhan, Jyotirmayee Bahinipati, Asha Dhinakaran, Anandaraj, Kandasamy Ravichandran
Introduction: Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Previous studies on the role of serum Uric Acid (UA) in COPD subjects have been both confounding and inconclusive. Aim: To measure the serum UA levels among COPD subjects and to correlate with different stages of the disease. Materials and Methods: The study included 39 stable COPD subjects (21 males, 18 females; 13 smokers, 26 nonsmokers; age group; 40 to 60 years) and compared with 46 control subjects from the general population...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206936/birthweight-of-singletons-born-after-cleavage-stage-or-blastocyst-transfer-in-fresh-and-warming-cycles
#18
Anick De Vos, Samuel Santos-Ribeiro, Lisbet Van Landuyt, Hilde Van de Velde, Herman Tournaye, Greta Verheyen
STUDY QUESTION: Does extended culture to the blastocyst stage affect singleton birthweight after either fresh or vitrified-warmed embryo transfer? SUMMARY ANSWER: Singleton birthweight z-scores did not vary significantly after a fresh blastocyst transfer, whereas the additional effect of vitrification remains inconclusive. WHAT IS KNOWN ALREADY: Observational studies have associated extended culture with an increased risk of preterm birth and low birthweight...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29206653/ginkgo-biloba-and-its-potential-role-in-glaucoma
#19
Jessica Minjy Kang, Shan Lin
PURPOSE OF REVIEW: This study will review the research on the effect of ginkgo biloba extract (GBE) on patients with glaucoma. RECENT FINDINGS: GBE appears to increase ocular blood flow in those with glaucoma. However, data on visual field outcomes are inconclusive. SUMMARY: GBE has been shown to have antioxidant and vascular effects, making it potentially effective in treating glaucoma. Published data are limited but show an increase in ocular blood flow after GBE administration...
December 4, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29205339/acne-in-late-adolescence-and-risk-of-prostate-cancer
#20
Henrik Ugge, Ruzan Udumyan, Jessica Carlsson, Ove Andrén, Scott Montgomery, Sabina Davidsson, Katja Fall
Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n= 243,187)...
December 4, 2017: International Journal of Cancer. Journal International du Cancer
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