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https://www.readbyqxmd.com/read/29444346/prenatal-vitamin-d-status-and-respiratory-and-allergic-outcomes-in-childhood-a-meta-analysis-of-observational-studies
#1
REVIEW
Rosa M Pacheco-González, Luis García-Marcos, Eva Morales
Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis was conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions. Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function...
February 14, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29443355/precarious-employment-and-occupational-accidents-and-injuries-a-systematic-review
#2
Isa Koranyi, Johanna Jonsson, Torkel Rönnblad, Leo Stockfelt, Theo Bodin
bjectives Precarious employment conditions have become more common in many countries over the last decades, and have been linked to various adverse health outcomes. The objective of this review was to collect and summarize existing scientific research of the relationship between dimensions of precarious employment and the rate of occupational injuries. Methods A protocol was developed in accordance with the PRISMA-P checklist for systematic literature reviews. We searched PubMed, Web of Science and Scopus for articles on observational studies from North America, Europe, Australia and New Zealand published in peer-reviewed journals 1990-2017...
February 14, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29440752/one-step-noninvasive-prenatal-testing-nipt-for-autosomal-recessive-homozygous-point-mutations-using-digital-pcr
#3
Mun Young Chang, Soyeon Ahn, Min Young Kim, Jin Hee Han, Hye-Rim Park, Han Kyu Seo, Jinsun Yoon, Seungmin Lee, Doo-Yi Oh, Changsoo Kang, Byung Yoon Choi
Previously, we introduced a noninvasive prenatal testing (NIPT) protocol for diagnosing compound heterozygous autosomal recessive point mutations via maternal plasma DNA and simulated control genomic DNA sampling based on fetal DNA fraction. In our present study, we have improved our NIPT protocol to make it possible to diagnose homozygous autosomal recessive point mutations without the need to acquire fetal DNA fraction. Moreover, chi-squared test and empirical statistical range based on the proportion of mutant allele reads among the total reads served as the gatekeeping method...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440009/u-shaped-association-between-serum-uric-acid-levels-with-cardiovascular-and-all-cause-mortality-in-the-elderly-the-role-of-malnourishment
#4
Wei-Cheng Tseng, Yung-Tai Chen, Shuo-Ming Ou, Chia-Jen Shih, Der-Cherng Tarng
BACKGROUND: The link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)-related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA and CVD outcomes. Therefore, we investigated whether SUA-predicted mortality and the effect-modifying roles of malnourishment in older people. METHODS AND RESULTS: A longitudinal Taiwanese cohort including 127 771 adults 65 years and older participating in the Taipei City Elderly Health Examination Program from 2001 to 2010 were stratified by 1-mg/dL increment of SUA...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29439690/a-systematic-review-of-the-effects-of-acupuncture-on-xerostomia-and-hyposalivation
#5
Zainab Assy, Henk S Brand
BACKGROUND: Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupuncture on oral dryness. METHODS: Pubmed and Web of Science were electronically searched. Reference lists of the included studies and relevant reviews were manually searched...
February 13, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29439354/effects-of-gender-and-other-confounding-factors-on-leptin-concentrations-in-alzheimer-s-disease-evidence-from-the-combined-analysis-of-27-case-control-studies
#6
Futao Zhou, Shuangrong Chen
Leptin, as a link between fat mass and the brain, has been reported to be associated with gender. The gender differences in leptin levels between Alzheimer's disease (AD) and healthy elderly controls are inconclusive so far. To quantitatively summarize the leptin data available from female and male patients with AD, we searched PubMed and EMBASE for articles published from inception to July 20, 2017. Data were extracted from 27 studies, consisting of 3,014 participants. The pooled results showed that the overall leptin levels were lower in AD (Hedges' g = -0...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438805/the-correlation-between-national-health-service-trusts-clinical-trial-activity-and-both-mortality-rates-and-care-quality-commission-ratings-a-retrospective-cross-sectional-study
#7
L Jonker, S J Fisher
OBJECTIVES: Evidence supporting the notion that clinical research activity in itself is of benefit to organisations as a whole is inconclusive. In the recent past, a positive association between research activity and reduced mortality has been shown. This study aimed to ascertain if clinical research activity is associated with established organisational outcome measures. STUDY DESIGN: Retrospective cross-sectional study. METHODS: For 129 English National Health Service hospital Trusts, National Institute for Health Research study activity data, Summary Hospital-level Mortality Indicator (SHMI) scores and Care Quality Commission (CQC) ratings were collected...
February 10, 2018: Public Health
https://www.readbyqxmd.com/read/29438522/ras-mutation-analysis-in-circulating-tumor-dna-from-patients-with-metastatic-colorectal-cancer-the-ageo-rasanc-prospective-multicenter-study
#8
J B Bachet, O Bouché, J Taieb, O Dubreuil, M L Garcia, A Meurisse, C Normand, J M Gornet, P Artru, S Louafi, F Bonnetain, A Thirot-Bidault, I Baumgaertner, R Coriat, D Tougeron, T Lecomte, F Mary, T Aparicio, L Marthey, V Taly, H Blons, D Vernerey, P Laurent-Puig
Background: RAS mutations are currently sought for in tumor samples, which takes a median of almost 3 weeks in western European countries. This creates problems in clinical situations that require urgent treatment and for inclusion in therapeutic trials that need RAS status for randomization. Analysis of circulating tumor DNA might help to shorten the time required to determine RAS mutational status prior to anti-EGFR antibody therapy for metastatic colorectal cancer. Here we compared plasma versus tissue RAS analysis in a large prospective multicenter cohort...
February 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29438001/association-between-shiftwork-and-the-risk-of-colorectal-cancer-in-females-a-population-based-case-control-study
#9
Wa Mwenga Walasa, Renee N Carey, Si Si, Lin Fritschi, Jane S Heyworth, Renae C Fernandez, Terry Boyle
OBJECTIVE: Research indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case-control study...
February 3, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29437910/modern-diagnosis-of-gerd-the-lyon-consensus
#10
REVIEW
C Prakash Gyawali, Peter J Kahrilas, Edoardo Savarino, Frank Zerbib, Francois Mion, André J P M Smout, Michael Vaezi, Daniel Sifrim, Mark R Fox, Marcelo F Vela, Radu Tutuian, Jan Tack, Albert J Bredenoord, John Pandolfino, Sabine Roman
Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal testing include advanced grade erosive oesophagitis (LA grades C and D), long-segment Barrett's mucosa or peptic strictures on endoscopy or distal oesophageal acid exposure time (AET) >6% on ambulatory pH or pH-impedance monitoring. A normal endoscopy does not exclude GERD, but provides supportive evidence refuting GERD in conjunction with distal AET <4% and <40 reflux episodes on pH-impedance monitoring off proton pump inhibitors...
February 3, 2018: Gut
https://www.readbyqxmd.com/read/29437863/associations-between-socioeconomic-status-and-chronic-kidney-disease-a-meta-analysis
#11
REVIEW
Xiaoxi Zeng, Jing Liu, Sibei Tao, Hyokyoung G Hong, Yi Li, Ping Fu
BACKGROUND: Socioeconomic status (SES) has long been conjectured to be associated with the incidence and progression of chronic kidney disease (CKD), but few studies have examined this quantitatively. This meta-analysis aims to fill this gap. METHODS: A systematic literature review was performed using Medline and EMBASE to identify observational studies on associations between SES and incidence and progression of CKD, published between 1974 and March 2017. Individual results were meta-analysed using a random effects model, in line with Meta-analysis of Observational Studies in Epidemiology guidelines...
February 2, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29437484/the-effects-of-thai-yoga-on-physical-fitness-a-meta-analysis-of-randomized-control-trials
#12
Chuenjid Kongkaew, Parinya Lertsinthai, Katechan Jampachaisri, Pajaree Mongkhon, Peerapong Meesomperm, Kunwarang Kornkaew, Phichamon Malaiwong
OBJECTIVES: Thai yoga is a traditional Thai exercise used for improving health-related physical fitness. Many studies have evaluated these effects, but their results remain inconclusive. This meta-analysis aimed to examine the effectiveness of Thai yoga on physical fitness. DESIGN/METHODS: PubMed, EMBASE, CINAHL, Cochrane library, Thai Library Integrated System (ThaiLis), Physiotherapy Evidence Database (PEDro), National Rehabilitation Information Center (Rehabdata), Scopus, Web of Science, Thai University library databases/journals, and Thai Physical Therapy database up to March 2016 were searched for randomized controlled trials (RCTs) examining the effect of Thai yoga exercise compared with normal daily activities as controls, in any language...
February 13, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29437311/sudden-headache-lumbar-puncture-and-the-diagnosis-of-subarachnoid-hemorrhage-in-patients-with-a-normal-computed-tomography-scans
#13
Joaquín Valle Alonso, Francisco Javier Fonseca Del Pozo, Manuel Vaquero Álvarez, Juan José De la Fuente Carillo, José Carlos Llamas, Yelda Hernández Montes
OBJECTIVES: To assess the usefulness of computed tomography (CT) to identify subarachnoid bleeding in patients with neurologic deficits seeking emergency care for sudden headache within 6 hours of onset of symptoms. MATERIAL AND METHODS: Retrospective observational study of patients presenting with sudden nontraumatic headache peaking during the previous hour in the absence of neurologic deficits. We ordered CT scans for all patients, and if the scan was normal we performed a lumbar puncture...
February 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29436330/prediction-of-electroconvulsive-therapy-response-and-remission-in-major-depression-meta-analysis
#14
Linda van Diermen, Seline van den Ameele, Astrid M Kamperman, Bernard C G Sabbe, Tom Vermeulen, Didier Schrijvers, Tom K Birkenhäger
BACKGROUND: Electroconvulsive therapy (ECT) is considered to be the most effective treatment in severe major depression. The identification of reliable predictors of ECT response could contribute to a more targeted patient selection and consequently increased ECT response rates. Aims To investigate the predictive value of age, depression severity, psychotic and melancholic features for ECT response and remission in major depression. METHOD: A meta-analysis was conducted according to the PRISMA statement...
February 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29436194/comparison-of-rhythm-and-rate-control-strategies-for-stroke-occurrence-in-a-prospective-cohort-of-atrial-fibrillation-patients
#15
Yu Jeong Choi, Ki Woon Kang, Tae Hoon Kim, Myung Jin Cha, Jung Myung Lee, Junbeom Park, Jin Kyu Park, Jaemin Shim, Jae Sun Uhm, Jun Kim, Hyung Wook Park, Eue Keun Choi, Jin Bae Kim, Changsoo Kim, Young Soo Lee, Boyoung Joung
PURPOSE: Comparisons of rhythm and rate control strategies for stroke prevention in patients with atrial fibrillation (AF) are still inconclusive. We compared differences in clinical outcomes between the rhythm and rate control strategies. MATERIALS AND METHODS: The COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry prospectively enrolled 6000 patients who were treated for AF using real-world guideline adherence at multiple referral centers...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29435567/benefits-and-harms-of-cranial-electrical-stimulation-for-chronic-painful-conditions-depression-anxiety-and-insomnia-a-systematic-review
#16
Paul G Shekelle, Ian A Cook, Isomi M Miake-Lye, Marika Suttorp Booth, Jessica M Beroes, Selene Mak
Background: Cranial electrical stimulation (CES) is increasingly popular as a treatment, yet its clinical benefit is unclear. Purpose: To review evidence about the benefits and harms of CES for adult patients with chronic painful conditions, depression, anxiety, and insomnia. Data Sources: Several databases from inception to 10 October 2017 without language restrictions and references from experts, prior reviews, and manufacturers. Study Selection: Randomized controlled trials of CES versus usual care or sham CES that reported pain, depression, anxiety, or sleep outcomes in any language...
February 13, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29434458/assessing-heart-rate-variability-as-a-surrogate-measure-of-cardiac-autonomic-function-in-chronic-traumatic-spinal-cord-injury
#17
Rasha El-Kotob, B Catharine Craven, Sunita Mathur, David S Ditor, Paul Oh, Masae Miyatani, Mary C Verrier
Background: Although cardiac autonomic dysfunction is a contributing factor for cardiovascular disease development in individuals with a spinal cord injury (SCI), it remains poorly understood. Heart rate variability (HRV) analysis has the potential to non-invasively assess the cardiac autonomic nervous system. The study objectives are (a) to determine if there are differences in HRV measures across neurological level of impairment (NLI) and American Spinal Cord Injury Association Impairment Scale (AIS) subgroups, and (b) to determine if there is a relationship between HRV frequency measures (low frequency [LF] and high frequency [HF]) at rest...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29434024/socioeconomic-deprivation-mortality-and-health-of-within-city-migrants-a-population-cohort-study
#18
Ravi Maheswaran, Mark Strong, Phil Clifford, Louise Brewins
BACKGROUND: Evidence linking selective migration (the situation where people in good health move from deprived to affluent areas, whilst people in poor health move in the opposite direction) within local areas to mortality is inconclusive. METHODS: Mortality in within-city migrants was examined using a Sheffield population cohort, adjusted for moves to care homes. The cohort comprised 310 894 people aged 25+ years in 2001 followed up for 9.18 years, with 42 252 (13...
February 6, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29434004/a-systematic-review-of-adolescent-girl-program-implementation-in-low-and-middle-income-countries-evidence-gaps-and-insights
#19
REVIEW
Nicole A Haberland, Katharine J McCarthy, Martha Brady
Increasing attention to adolescent girls has generated an abundance of programs and a growing body of research on adolescent girls in low- and middle-income countries. Despite this, questions remain about what implementation approaches in program design are most effective, hindering efficient resource allocation, program scale-up, and replication across settings. To address these questions, we conducted a systematic review to identify lessons learned and gaps in the evidence base. We searched four electronic databases to identify studies published between 1990 and 2014 that evaluated health, social, and/or economic development programs targeting adolescent girls in low- and middle-income countries...
February 9, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29433009/paternity-tests-in-mexico-results-obtained-in-3005-cases
#20
M E García-Aceves, O Romero Rentería, X X Díaz-Navarro, H Rangel-Villalobos
National and international reports regarding the paternity testing activity scarcely include information from Mexico and other Latin American countries. Therefore, we report different results from the analysis of 3005 paternity cases analyzed during a period of five years in a Mexican paternity testing laboratory. Motherless tests were the most frequent (77.27%), followed by trio cases (20.70%); the remaining 2.04% included different cases of kinship reconstruction. The paternity exclusion rate was 29.58%, higher but into the range reported by the American Association of Blood Banks (average 24...
February 6, 2018: Journal of Forensic and Legal Medicine
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