Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Francesco Muratore, Luigi Boiardi, Alberto Cavazza, Alessandra Bisagni, Luca Cimino, Luca De Simone, Angelo Ghidini, Giuseppe Malchiodi, Marc Corbera-Bellalta, Maria Cinta Cid, Alessandro Zerbini, Carlo Salvarani, Stefania Croci
Giant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and miRNA up-regulation in GCA; to identify the role of miR-146a and miR-146b. Primary cultures from TABs were treated with IL-1β, IL-6, soluble IL-6R (sIL6R), IL-17, IL-22, IFNγ, LPS and PolyIC...
February 29, 2024: Journal of Autoimmunity