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MiR-146a gene

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https://www.readbyqxmd.com/read/29137139/deduction-of-novel-genes-potentially-involved-in-osteoblasts-of-rheumatoid-arthritis-using-next-generation-sequencing-and-bioinformatic-approaches
#1
Yi-Jen Chen, Wei-An Chang, Ya-Ling Hsu, Chia-Hsin Chen, Po-Lin Kuo
The role of osteoblasts in peri-articular bone loss and bone erosion in rheumatoid arthritis (RA) has gained much attention, and microRNAs are hypothesized to play critical roles in the regulation of osteoblast function in RA. The aim of this study is to explore novel microRNAs differentially expressed in RA osteoblasts and to identify genes potentially involved in the dysregulated bone homeostasis in RA. RNAs were extracted from cultured normal and RA osteoblasts for sequencing. Using the next generation sequencing and bioinformatics approaches, we identified 35 differentially expressed microRNAs and 13 differentially expressed genes with potential microRNA-mRNA interactions in RA osteoblasts...
November 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133238/mir-146a-targets-c-met-and-abolishes-colorectal-cancer-liver-metastasis
#2
Anne-Marie Bleau, Miriam Redrado, Estanislao Nistal-Villan, Maria Villalba, Francisco Exposito, Esther Redin, Arrate L de Aberasturi, Leyre Larzabal, Javier Freire, Javier Gomez-Roman, Alfonso Calvo
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types of cancer, is disease progression via liver metastases. At this stage, very few treatment options are available for patients, and the disease remains incurable. Herein, we used a well-established mouse model of CRC liver metastasis (CLM) to identify new regulators of this process. Using serial transplantation of murine MC38 adenocarcinoma cells, we obtained liver metastatic variants that displayed extremely strong colonization abilities...
November 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29128203/study-of-correlation-between-genetic-variants-in-three-microrna-genes-hsa-mir-146a-hsa-mir-502-binding-site-hsa-mir-27a-and-breast-cancer-risk
#3
S Parchami Barjui, S Reiisi, S O Ebrahimi, B Shekari
BACKGROUND AND AIM: MicroRNAs (miRNAs) represent noncoding RNAs that play a role in the gene regulation of oncogenes and tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNA genes are associated with risk of cancer. Some of these SNPs are more common including rs2910164 in the miR-146a, rs895819 in the miR-27a, and rs2910164 in the miR-502 binding site of the SET8. Our aim was to investigate the association between these polymorphisms and the risk of breast cancer in an Iranian population...
November 8, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29127522/common-genetic-variation-within-mir-146a-predicts-disease-onset-and-relapse-in-multiple-sclerosis
#4
Yuan Zhou, Ming Chen, Steve Simpson, Robyn M Lucas, Jac C Charlesworth, Nicholas Blackburn, Ingrid van der Mei, Anne-Louise Ponsonby, Bruce V Taylor
Despite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized change in disability), using a longitudinal cohort study of persons with a first demyelinating event followed up to their 5-year review...
November 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29126434/whole-blood-microrna-expression-pattern-differentiates-patients-with-rheumatoid-arthritis-their-seropositive-first-degree-relatives-and-healthy-unrelated-control-subjects
#5
Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee, Hani El-Gabalawy
BACKGROUND: Epigenetic mechanisms can integrate gene-environment interactions that mediate disease transition from preclinical to clinically overt rheumatoid arthritis (RA). To better understand their role, we evaluated microRNA (miRNA, miR) expression profile in indigenous North American patients with RA who were positive for anticitrullinated protein antibodies; their autoantibody-positive, asymptomatic first-degree relatives (FDRs); and disease-free healthy control subjects (HCs). METHODS: Total RNA was isolated from whole blood samples obtained from HC (n = 12), patients with RA (n = 18), and FDRs (n = 12)...
November 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29123165/deep-sequencing-and-analyses-of-mirnas-isomirs-and-mirna-induced-silencing-complex-mirisc-associated-mirnome-in-primary-human-chondrocytes
#6
Abdul Haseeb, Mohammad Shahidul Makki, Nazir M Khan, Imran Ahmad, Tariq M Haqqi
MicroRNAs, a group of small, noncoding RNAs that post-transcriptionally regulate gene expression, play important roles in chondrocyte function and in the development of osteoarthritis. We characterized the dynamic repertoire of the chondrocyte miRNome and miRISC-associated miRNome by deep sequencing analysis of primary human chondrocytes. IL-1β treatment showed a modest effect on the expression profile of miRNAs in normal and osteoarthritis (OA) chondrocytes. We found a number of miRNAs that showed a wide range of sequence modifications including nucleotide additions and deletions at 5' and 3' ends; and nucleotide substitutions...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122314/blood-transcriptional-and-microrna-responses-to-short-term-exposure-to-disinfection-by-products-in-a-swimming-pool
#7
Almudena Espín-Pérez, Laia Font-Ribera, Karin van Veldhoven, Julian Krauskopf, Lutzen Portengen, Marc Chadeau-Hyam, Roel Vermeulen, Joan O Grimalt, Cristina M Villanueva, Paolo Vineis, Manolis Kogevinas, Jos C Kleinjans, Theo M de Kok
BACKGROUND: Swimming in a chlorinated pool results in high exposure levels to disinfection by-products (DBPs), which have been associated with an increased risk of bladder cancer. OBJECTIVES: By studying molecular responses at the blood transcriptome level we examined the biological processes associated with exposure to these compounds. METHODS: Whole-genome gene expression and microRNA analysis was performed on blood samples collected from 43 volunteers before and 2h after 40min swimming in an indoor chlorinated pool (PISCINAII study)...
January 2018: Environment International
https://www.readbyqxmd.com/read/29113388/association-of-mir-146a-mir-149-mir-196a2-mir-499-gene-polymorphisms-with-ischemic-stroke-in-a-chinese-people
#8
Hong-Cheng Luo, Qi-Sheng Luo, Chun-Fang Wang, Ming Lei, Bei-Lin Li, Ye-Sheng Wei
This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case-control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was used to detect genetic polymorphisms of miRNAs,and the relationship of genotype in each group and blood lipid was compared and analyzed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107863/elevated-expression-of-mir-146-mir-139-and-mir-340-involved-in-regulating-th1-th2-balance-with-acute-exposure-of-fine-particulate-matter-in-mice
#9
Tianfang Hou, Jiping Liao, Cheng Zhang, Chao Sun, Xueying Li, Guangfa Wang
Airborne fine particulate matter (PM2.5) is detrimental to human health, and frequently leads to a variety of lung diseases. Recently, IARC conclude that particulate matter is carcinogenic to humans (level one). However, the pulmonary toxicological mechanism induced by PM2.5 remains obscure. Our previous studies confirmed that PM2.5 hurt the human immune system by means of causing the imbalance of Th1/Th2 lymphocytes. MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential mediators of environmental effects, which play an important role in the regulation of CD4(+)T lymphocyte differentiation...
November 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29074132/microrna-146a-promotes-red-spotted-grouper-nervous-necrosis-virus-rgnnv-replication-by-targeting-traf6-in-orange-spotted-grouper-epinephelus-coioides
#10
Songwei Ni, Yepin Yu, Jingguang Wei, Lingli Zhou, Shina Wei, Yang Yan, Xiaohong Huang, Youhua Huang, Qiwei Qin
MicroRNA-146a (miR-146a) has been demonstrated to function as a negative regulator of cellular immune responses against pathogens in mammals, however, little information focused on its functions in lower vertebrates. In this study, we investigated the regulatory roles of orange spotted grouper, Epinephelus coioides miR-146a during red spotted grouper nervous necrosis virus (RGNNV) infection. During RGNNV infection in grouper spleen (GS) cells, the endogenous expression level of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) significantly increased along with the infection time...
October 24, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29070573/mir-34c-5p-and-camkii-are-involved-in-aldosterone-induced-fibrosis-in-kidney-collecting-duct-cells
#11
Eui-Jung Park, Hyun Jun Jung, Hyo-Jung Choi, Jeong-In Cho, Hye-Jeong Park, Tae-Hwan Kwon
Mineralocorticoids trigger a pro-fibrotic process in kidney. In mouse cortical collecting duct cells (mpkCCDc14 cells), the present study addressed two main questions: 1) what are miRNAs and their target genes changed by aldosterone? and 2) what do miRNAs in response to aldosterone regulate signaling pathways related to fibrosis? Microarray chip assay was done in cells in the absence or presence of aldosterone treatment (10(-6)M, 3 d). The candidate miRNAs were identified by the criteria of more than 30% of fold-change among the significantly changed miRNAs (P value < 0...
October 25, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29058209/the-rs2910164-variant-is-associated-with-reduced-mir-146a-expression-but-not-cytokine-levels-in-patients-with-type-2-diabetes
#12
B Alipoor, H Ghaedi, R Meshkani, M D Omrani, Z Sharifi, T Golmohammadi
PURPOSE: Previous reports have demonstrated that genetic variations in microRNAs regulome could affect microRNAs-mediated regulation. Therefore, in the present study we were aimed at (1) comparison of microRNA 146-a (miR-146a) peripheral blood mononuclear cells (PBMCs) and plasma levels between diabetic patients and controls, and (2) investigating the possible association of rs2910164 with miR-146a and its related target genes expression and also serum cytokine levels. METHODS: The study population consisted of 60 subjects including 30 type 2 diabetes (T2D) patients and 30 controls with determined genotypes for rs2910164...
October 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29038477/long-non-coding-hcg18-promotes-intervertebral-disc-degeneration-by-sponging-mir-146a-5p-and-regulating-traf6-expression
#13
Yanhai Xi, Tingwang Jiang, Weiheng Wang, Jiangming Yu, Yang Wang, Xueming Wu, Yunfei He
Intervertebral disc degeneration (IDD) is associated with the deterioration of nucleus pulposus (NP) cells due to hypertrophic differentiation and calcification. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in the development of IDD. Using bioinformatics prediction, we hereby sought to identify the lncRNAs that regulate the expression of microRNA-146a-5p (miR-146a-5p), an IDD-related inflammatory factor. Our study demonstrated that lncRNA HCG18 acted as an endogenous sponge to down-regulate miR-146a-5p expression in the NP cells by directly binding to miR-146a-5p...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037553/association-of-mir-146a-rs2910164-and-mir-222-rs2858060-polymorphisms-with-the-risk-of-polycystic-ovary-syndrome-in-iranian-women-a-case-control-study
#14
Amir Hossein Hosseini, Leila Kohan, Azita Aledavood, Sara Rostami
OBJECTIVE: Today, many single nucleotide polymorphisms in microRNA genes are known to alter the microRNA expression levels or processing causing susceptibility of several human diseases. The present study aimed to investigate the association of microRNA-146a (rs2910164) and microRNA-222 (rs2858060) polymorphisms with susceptibility to polycystic ovary syndrome (PCOS) in an Iranian population. MATERIALS AND METHODS: This case-control study was performed on 205 patients with PCOS and 205 normal women as the control group...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29021573/an-nf-%C3%AE%C2%BAb-microrna-regulatory-network-tunes-macrophage-inflammatory-responses
#15
Mati Mann, Arnav Mehta, Jimmy L Zhao, Kevin Lee, Georgi K Marinov, Yvette Garcia-Flores, David Baltimore
The innate inflammatory response must be tightly regulated to ensure effective immune protection. NF-κB is a key mediator of the inflammatory response, and its dysregulation has been associated with immune-related malignancies. Here, we describe a miRNA-based regulatory network that enables precise NF-κB activity in mouse macrophages. Elevated miR-155 expression potentiates NF-κB activity in miR-146a-deficient mice, leading to both an overactive acute inflammatory response and chronic inflammation. Enforced miR-155 expression overrides miR-146a-mediated repression of NF-κB activation, thus emphasizing the dominant function of miR-155 in promoting inflammation...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28990079/effect-of-mir%C3%A2-146a%C3%A2-5p-on-tumor-growth-in-nsclc-using-chick-chorioallantoic-membrane-assay-and-bioinformatics-investigation
#16
Wen-Ting Huang, Wei-Luan Cen, Rong-Quan He, You Xie, Yu Zhang, Ping Li, Ting-Qing Gan, Gang Chen, Xiao-Hua Hu
Our previous study demonstrated that the expression of miR‑146a‑5p was downregulated in non‑small cell lung cancer (NSCLC) tissue, which affected the progression and prognosis of patients with NSCLC. Thus, the present study was conducted to investigate the functional mechanism of miR‑146a‑5p in tumorigenesis and angiogenesis in NSCLC. Following the construction of a H460 NSCLC cell line in which miR‑146a‑5p was overexpressed via lentivirus transduction, the NSCLC chick embryo chorioallantoic membrane (CAM) model was established by transplanting miR‑146a‑5p‑overexpressing NSCLC cells into the CAM...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986402/microrna-expression-profiles-and-type-1-diabetes-mellitus-systematic-review-and-bioinformatic-analysis
#17
Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M De Souza, Daisy Crispim
Growing evidence indicates that microRNAs (miRNAs) have a key role in processes involved in type 1 diabetes mellitus (T1DM) pathogenesis, including immune system functions and beta-cell metabolism and death. Although dysregulated miRNA profiles have been identified in T1DM patients, results are inconclusive; with only few miRNAs being consistently dysregulated among studies. Thus, we performed a systematic review of the literature on the subject, followed by bioinformatic analysis, to point out which miRNAs are dysregulated in T1DM-related tissues and in which pathways they act...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28975995/mir-146a-inhibits-proliferation-and-induces-apoptosis-in-murine-osteoblastic-mc3t3-e1-by-regulating-bcl2
#18
B Zhang, J Yi, C-L Zhang, Q-H Zhang, J-F Xu, H-Q Shen, D-W Ge
OBJECTIVE: The dysregulation of proliferation and apoptosis plays a significant role in the pathogenesis of hormone-induced osteonecrosis of femoral head (ONFH). The research aimed to explore the regulatory role of miR-146a in dexamethasone (DEX)-induced proliferation and apoptosis change in MC3T3-E1 cells from murine osteoblastic. MATERIAL AND METHODS: In this study, MC3T3-E1 was co-cultured with 10-7 DEX for 6 h, then RT-PCR was employed to test the expression level of miR-146a and Bcl2...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28950676/association-between-microrna-146a-and-microrna-196a2-genes-polymorphism-and-breast-cancer-risk-in-north-indian-women
#19
Vijay Kumar Bodal, Shruti Sangwan, Manjit Singh Bal, Mohanvir Kaur, Sidarth Sharma, Bhavleen Kaur
Background: Micro RNAs (miRNAs) are small, noncoding RNA molecules. They can function as either oncogenes or tumor suppressor genes. Single nucleotide polymorphisms (SNP) present in the pre-miRNA region could affect the processing of miRNA and thus alter mature miRNA expression. The studies done so far had shown conflicting results regarding association of two common polymorphisms i.e.hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913 with breast cancer. OBJECTIVE: In the study, we examined the hsa-miR-146 rs2910164 and hsa-miR-196a2 rs11614913 SNP association with breast cancer patients in north Indian women...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28938006/association-between-circulating-mirnas-and-spinal-involvement-in-patients-with-axial-spondyloarthritis
#20
Klára Prajzlerová, Kristýna Grobelná, Markéta Hušáková, Šárka Forejtová, Astrid Jüngel, Steffen Gay, Jiří Vencovský, Karel Pavelka, Ladislav Šenolt, Mária Filková
OBJECTIVES: Dysregulation of miRNAs and their target genes contributes to the pathophysiology of autoimmune diseases. Circulating miRNAs may serve as diagnostic/prognostic biomarkers. We aimed to investigate the association between circulating miRNAs, disease activity and spinal involvement in patients with axial spondyloarthritis (AxSpA). METHODS: Total RNA was isolated from the plasma of patients with non-radiographic (nr)AxSpA, patients with ankylosing spondylitis (AS) and healthy controls (HC) via phenol-chloroform extraction...
2017: PloS One
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