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MiR-146a gene

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https://www.readbyqxmd.com/read/27893422/pttg1-regulated-by-mir-146-3p-promotes-bladder-cancer-migration-invasion-metastasis-and-growth
#1
Wei Xiang, Xinchao Wu, Chao Huang, Miao Wang, Xian Zhao, Gang Luo, Yawei Li, Guosong Jiang, Xingyuan Xiao, Fuqing Zeng
Pituitary tumor-transforming gene 1 (PTTG1) is identified as an oncogene, and overexpresses in many tumors. However, the role of PTTG1 in bladder cancer (BC) hasn't yet been characterized well. In this study, we showed the expression of PTTG1 mRNA and protein were both significantly increased in BC tissues and cells. The PTTG1 protein levels were positive correlated with increased tumor size, tumor-node-metastasis (TNM) stage, lymphatic invasion and distant metastasis of BC. PTTG1 knockdown dramatically suppressed the migration, invasion, metastasis and growth, and induced senescence and cell-cycle arrest at G0/G1 phase of BC cells...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27888401/the-impact-of-chronic-hepatitis-c-infection-on-cholesterol-metabolism-in-pbmcs-is-associated-with-microrna-146a-expression
#2
M Sidorkiewicz, M Grek, B Jozwiak, A Krol, A Piekarska
Chronic hepatitis C (CHC) infection is known to induce important changes in host cholesterol metabolism. MicroRNAs (miRNAs) regulate the expression of many genes and, in consequence, control various processes, including human metabolism and response to viral infection. Recently, the alteration of the immune-associated miR-146a, which is abundantly present in peripheral blood mononuclear cells (PBMCs), was found in some viral infections. The study aimed to analyse the influence of hepatitis C virus (HCV) infection on miR-146a expression in PBMCs in vivo and in vitro, as well as to assess the possible impact of miR-146a alteration on the intracellular cholesterol level in PBMCs...
November 25, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27888002/polymorphisms-in-mir499a-and-mir125a-gene-are-associated-with-autoimmune-thyroid-diseases
#3
TianTian Cai, Jie Li, Xiaofei An, Ni Yan, Danfeng Li, Yanfei Jiang, Wen Wang, Liangfeng Shi, Qiu Qin, Ronghua Song, Guofei Wang, Wenjuan Jiang, Jin-An Zhang
BACKGROUND: Single nucleotide polymorphisms (SNPs) of the miR-146a, miR-499a and miR-125a have been shown to be associated with the susceptibility to several autoimmune diseases. This study was conducted to identify the association of SNPs rs2910164, rs57095329, rs3746444 and rs12976445 with autoimmune thyroid diseases (AITDs) in a Chinese Han population. METHODS: We enrolled 1061 patients with AITDs, including 701 patients with Graves' disease (GD) and 360 patients with Hashimoto's thyroiditis (HT), and 938 healthy individuals for a case-control genetic association study...
November 22, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27873272/analysis-of-viral-and-cellular-micrornas-in-ebv-infected-cells
#4
Rebecca L Skalsky
MicroRNAs are small, noncoding RNAs that posttranscriptionally regulate gene expression. The discovery of this relatively new mode of gene regulation as well as studies showing the prognostic value of viral and cellular miRNAs as biomarkers, such as in cancer progression, has stimulated the development of many methods to characterize miRNAs. EBV encodes 25 viral precursor microRNAs within its genome that are expressed during lytic and latent infection. In addition to viral miRNAs, EBV infection induces the expression of specific cellular oncogenic miRNAs, such as miR-155, miR-146a, miR-21, and others, that can contribute to the persistence of latently infected cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27867363/a-comparative-review-of-microrna-expression-patterns-in-autism-spectrum-disorder
#5
Steven D Hicks, Frank A Middleton
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a wide spectrum of deficits in social interaction, communication, and behavior. There is a significant genetic component to ASD, yet no single gene variant accounts for >1% of incidence. Posttranscriptional mechanisms such as microRNAs (miRNAs) regulate gene expression without altering the genetic code. They are abundant in the developing brain and are dysregulated in children with ASD. Patterns of miRNA expression are altered in the brain, blood, saliva, and olfactory precursor cells of ASD subjects...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27866933/evaluation-of-the-tobacco-heating-system-2-2-ths2-2-part-5-microrna-expression-from-a-90-day-rat-inhalation-study-indicates-that-exposure-to-ths-2-2-aerosol-causes-reduced-effects-on-lung-tissue-compared-with-cigarette-smoke
#6
Alain Sewer, Ulrike Kogel, Marja Talikka, Ee Tsin Wong, Florian Martin, Yang Xiang, Emmanuel Guedj, Nikolai V Ivanov, Julia Hoeng, Manuel C Peitsch
Modified-risk tobacco products (MRTP) are designed to reduce the individual risk of tobacco-related disease as well as population harm compared to smoking cigarettes. Experimental proof of their benefit needs to be provided at multiple levels in research fields. Here, we examined microRNA (miRNA) levels in the lungs of rats exposed to a candidate modified-risk tobacco products, the Tobacco Heating System (THS) 2.2 in a 90-day OECD TG-413 inhalation study. Our aim was to assess the miRNA response to THS2.2 aerosol compared with the response to combustible cigarettes (CC) smoke from the reference cigarette 3R4F...
November 17, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27866223/circulating-microrna-levels-predict-residual-beta-cell-function-and-glycaemic-control-in-children-with-type-1-diabetes-mellitus
#7
Nasim Samandari, Aashiq H Mirza, Lotte B Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim, Henrik B Mortensen, Flemming Pociot
AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated...
November 19, 2016: Diabetologia
https://www.readbyqxmd.com/read/27865919/differential-stress-induced-c-fos-expression-and-identification-of-region-specific-mirna-mrna-networks-in-the-dorsal-raphe-and-amygdala-of-high-responder-low-responder-rats
#8
Joshua L Cohen, Anooshah E Ata, Nateka L Jackson, Elizabeth J Rahn, Ryne C Ramaker, Sara Cooper, Ilan A Kerman, Sarah M Clinton
Chronic stress triggers a variety of physical and mental health problems, and how individuals cope with stress influences risk for emotional disorders. To investigate molecular mechanisms underlying distinct stress coping styles, we utilized rats that were selectively-bred for differences in emotionality and stress reactivity. We show that high novelty responding (HR) rats readily bury a shock probe in the defensive burying test, a measure of proactive stress coping behavior, while low novelty responding (LR) rats exhibit enhanced immobility, a measure of reactive coping...
November 16, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27865387/microrna-expression-signatures-in-lungs-of-mice-infected-with-mycobacterium-tuberculosis
#9
Thiago Malardo, Luiz Gustavo Gardinassi, Bernardo Pereira Moreira, Éverton Padilha, Júlio César Cetrulo Lorenzi, Luana Silva Soares, Ana Flávia Gembre, Isabela Cardoso Fontoura, Luciana Previato de Almeida, Isabel Kinney Ferreira de Miranda Santos, Célio Lopes Silva, Arlete Aparecida Martins Coelho-Castelo
Tuberculosis (TB) is a major public health concern worldwide; however the factors that account for resistance or susceptibility to disease are not completely understood. Although some studies suggest that the differential expression of miRNAs in peripheral blood of TB patients could be useful as biomarkers of active disease, their involvement during the inflammatory process in lungs of infected individuals is unknown. Here, we evaluated the global expression of miRNAs in the lungs of mice experimentally infected with Mycobacterium tuberculosis on 30 and 60 days post-infection...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27864711/mesenchymal-stem-cells-derived-exosomal-micrornas-contribute-to-wound-inflammation
#10
REVIEW
Dongdong Ti, Haojie Hao, Xiaobing Fu, Weidong Han
Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration. However, it remains challenging to control the inflammatory response and tolerance at systemic levels without causing toxicity to injured tissues. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and facilitate tissue repair by releasing exosomes, which generate a suitable microenvironment for inflammatory resolution. Exosomes contain several effective bioactive molecules and act as a cell-cell communication vehicle to influence cellular activities in recipient cells...
November 18, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27852797/modulation-of-mir-146a-complement-factor-h-mediated-inflammatory-responses-in-a-rat-model-of-temporal-lobe-epilepsy
#11
Fang He, Bei Liu, Qiang Meng, Yang Sun, Weiwen Wang, Chao Wang
Increasing evidence supports the involvement of inflammatory and immune processes in temporal lobe epilepsy (TLE). MicroRNAs (miRNA) represent small regulatory RNA molecules that have been shown to act as negative regulators of gene expression controlling different biological processes, including immune-system homeostasis and function. We investigated the expression and cellular distribution of miRNA-146a (miR-146a) in a rat model of TLE. Prominent upregulation of miR-146a activation was evident at 1 week after status epilepticus (SE) and persisted in the chronic phase...
November 16, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27845876/hypoxia-induced-microrna-146a-represses-bcl-2-through-traf6-irak1-but-not-smad4-to-promote-chondrocyte-autophagy
#12
Guanghui Chen, Xin Gao, Jing Wang, Cheng Yang, Yang Wang, Yonggang Liu, Weiwei Zou, Tielong Liu
It has been showed hypoxia stimulation promotes chondrocytes autophagy partly through HIF-1alpha, miR-146a and Bcl-2 progressively, and this mechanism represented the connection among hypoxia, miR-146a and autophagy, and provides a possible therapeutic strategy for osteoarthritis. However, the interaction between miR-146a and Bcl-2 is still unclear. Here in hypoxia environment, we quantified the three reported miR-146a targets: two inflammation related targets Traf6, IRAK1; and the only reported target in chondrocytes Smad4...
November 15, 2016: Biological Chemistry
https://www.readbyqxmd.com/read/27832663/mir-146a-5p-mediates-epithelial-mesenchymal-transition-of-oesophageal-squamous-cell-carcinoma-via-targeting-notch2
#13
Cong Wang, Wenxue Zhang, Lin Zhang, Xuan Chen, Fang Liu, Jing Zhang, Shanghui Guan, Yi Sun, Pengxiang Chen, Ding Wang, Effat Un Nesa, Yufeng Cheng, George M Yousef
BACKGROUND: Our previous study found that dysregulated microRNA-146a-5p (miR-146a-5p) is involved in oesophageal squamous cell cancer (ESCC) proliferation. This article aimed to evaluate its detailed mechanisms in ESCC epithelial-mesenchymal transition (EMT) progression. METHODS: Invasion assay, qRT-PCR and western blotting were used to validate the roles of miR-146a-5p and Notch2 in EMT progression. miRNA target gene prediction databases and dual-luciferase reporter assay were used to validate the target gene...
November 10, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27824903/mir-146a-polymorphism-rs2910164-predicts-colorectal-cancer-patients-susceptibility-to-liver-metastasis
#14
Tomohiro Iguchi, Sho Nambara, Takaaki Masuda, Hisateru Komatsu, Masami Ueda, Shinya Kidogami, Yushi Ogawa, Qingjiang Hu, Kuniaki Sato, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori
miR-146a plays important roles in cancer as it directly targets NUMB, an inhibitor of Notch signaling. miR-146a is reportedly regulated by a G>C polymorphism (SNP; rs2910164). This polymorphism affects various cancers, including colorectal cancer (CRC). However, the clinical significance of miR-146a polymorphism in CRC remains unclear. A total of 59 patients with CRC were divided into 2 groups: a CC/CG genotype (n = 32) and a GG genotype (n = 27), based on the miR-146a polymorphism. cDNA microarray analysis was performed using 59 clinical samples...
2016: PloS One
https://www.readbyqxmd.com/read/27818285/down-regulation-of-microrna-146a-is-associated-with-high-risk-human-papillomavirus-infection-and-epidermal-growth-factor-receptor-overexpression-in-penile-squamous-cell-carcinoma
#15
Elektra Peta, Rocco Cappellesso, Giulia Masi, Alessandro Sinigaglia, Marta Trevisan, Angela Grassi, Barbara Di Camillo, Elisa Vassarotto, Ambrogio Fassina, Giorgio Palù, Luisa Barzon
Dysregulation of host microRNA expression has been involved in the development and progression of human papillomavirus (HPV)-related tumors. Analysis of miR-146a expression in a series of 59 penile squamous cell carcinomas (PSCCs) showed that its levels were lower in high-risk HPV-positive than in HPV-negative PSCCs and inversely correlated with expression of epidermal growth factor receptor (EGFR), a known target for miR-146a. Analysis of genotype distribution for rs2910164, a common functional polymorphism of miR-146a, did not identify correlations with miR-146a levels and EGFR expression in PSCCs...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27797173/dipeptidyl-vinyl-sulfone-as-a-novel-chemical-tool-to-inhibit-hmgb1-nlrp3-inflammasome-and-inflamma-mirs-in-a%C3%AE-mediated-microglial-inflammation
#16
Ana Sofia Falcão, Luís A R Carvalho, Gonçalo Lidónio, Ana Rita Vaz, Susana Dias Lucas, Rui Moreira, Dora Brites
Rapid microglial activation and associated inflammatory pathways contribute to immune-defense and tissue repair in the central nervous system (CNS). However, persistent activation of these cells will ultimately result in vast production of pro-inflammatory mediators and other neurotoxic factors, which may induce neuronal damage and contribute to chronic neurodegenerative diseases, as Alzheimer's disease (AD). Therefore, small molecules with immunomodulatory effects on microglia may be considered as potential tools to counteract their pro-inflammatory phenotype and neuroimmune dysregulation in such disorders...
October 31, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27780686/micror-146-blocks-the-activation-of-m1-macrophage-by-targeting-signal-transducer-and-activator-of-transcription-1-in-hepatic-schistosomiasis
#17
Xing He, Rui Tang, Yue Sun, Yan-Ge Wang, Kui-Yang Zhen, Dong-Mei Zhang, Wei-Qing Pan
Schistosomiasis is a chronic disease caused by the parasite of the Schistosoma genus and is characterized by egg-induced hepatic granulomas and fibrosis. Macrophages play a central role in schistosomiasis with several studies highlighting their differentiation into M2 cells involved in the survival of infected mice through limitation of immunopathology. However, little is known regarding the mechanisms of regulating macrophage differentiation. Here, we showed that the early stage of infection by Schistosoma japonicum induced expression of type 1T-helper-cell (Th1) cytokine, interferon-γ (IFN-γ), leading to increase in M1 cells...
October 19, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27765085/differential-expression-of-micrornas-in-hepatitis-c-virus-mediated-liver-disease-between-african-americans-and-caucasians-implications-for-racial-health-disparities
#18
Pradip B Devhare, Robert Steele, Adrian M Di Bisceglie, David E Kaplan, Ratna B Ray
African Americans (AA) have higher hepatocellular carcinoma (HCC) and mortality rates than Caucasians Americans (CA). Chronic hepatitis C virus (HCV) infection leads to cirrhosis and HCC. HCV infection is highly prevalent in AA population compared to other racial groups. African Americans are also less likely to naturally clear HCV, potentially contributing to higher prevalence of HCV. However, the explanation for this disparity is currently unknown. Circulating microRNAs (miRNAs) in the blood are emerging as biomarkers for pathological conditions...
October 19, 2016: Gene Expression
https://www.readbyqxmd.com/read/27762791/mir-146a-gene-polymorphism-and-susceptibility-to-gastric-cancer
#19
Zahra Sadat Yadegari, Hassan Akrami, Seyed Vahid Hosseini, Nasrollah Erfani
No abstract text is available yet for this article.
October 20, 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27760486/micro-rna-320-as-a-novel-potential-biomarker-in-renal-ischemia-reperfusion
#20
Aydın Güçlü, Cengiz Koçak, Fatma Emel Koçak, Raziye Akçılar, Yavuz Dodurga, Aydın Akçılar, Mücahit Seçme
AIM: MicroRNAs (miR) are important diagnostic and treatment targets due to their different tissue expressions and their central position in the regulation of gene expressions. miR studies might pioneer emerging of new diagnostic tools and treatment goals in kidney diseases. Captopril (CAP) and telmisartan (TEL) were shown to be effective in ischemia reperfusion (IR) injury. There is not any study about the effect of TEL and CAP over miR-21-320-146a. Our aim was to study the effects of CAP and TEL over miR on renal IR model...
October 19, 2016: Renal Failure
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