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MiR-146a gene

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https://www.readbyqxmd.com/read/29762840/the-effect-of-mir-146a-gene-silencing-on-drug-resistance-and-expression-of-protein-of-p-gp-and-mrp1-in-epilepsy
#1
H-L Zhang, Y-H Lin, Y Qu, Q Chen
OBJECTIVE: To investigate the effect of miR-146a gene silencing on brain tissue and related drug-resistance proteins in rats and explore its resistance mechanism. MATERIALS AND METHODS: A rat model of chronic refractory epilepsy was established. The rats were divided into four groups: Normal group, Model group, Negative control group and AntagomiR-146a group. Hematoxylin and eosin (HE) stain was used to detect brain histopathological changes. We examined the expression of mRNA of miR-146a, multidrug resistance (MDR1) and multidrug-resistant associated protein (MRP1) by RT-PCR...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29749487/rs2910164-in-microrna%C3%A2-146a-confers-an-elevated-risk-of-depression-in-patients-with-coronary-artery-disease-by-modulating-the-expression-of-nos1
#2
Xinling Zhang, Qianqian Huo, Wei Sun, Chunxiang Zhang, Zongyin Wu, Bing Xing, Qiang Li
Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence has shown that single nucleotide polymorphisms located in pre‑microRNA (miRNA) or mature miRNA may modify various biological processes and affect the process of carcinogenesis, and the downregulation of neuronal nitric oxide synthase 1 (NOS1) can induce depression. It has been shown that NOS1 is the target gene of miR‑146a, and that the rs2910164 G/C polymorphism can downregulate the expression of miR‑146a...
April 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29733865/microrna-146-5p-mir-let-7c-5p-mir-221-and-mir-345-5p-are-differentially-expressed-in-respiratory-syncytial-virus-rsv-persistently-infected-hep-2-cells
#3
Eilam-Frenkel B, Naaman H, Berkic G, I Veksler-Lublinsky, G Rall, Shemer Y, Gopas J
Many viruses can establish non-cytolytic, chronic infections in host cells. Beyond the intrinsically interesting questions of how this long-term parasitism is achieved, persistently infected cells can be useful to study virus-host interactions. MicroRNAs (miRNAs) are a class of noncoding RNAs transcribed from the genomes of all multicellular organisms and some viruses. Individual miRNAs may regulate several hundred genes. In this research we have studied the expression of a selective group of host-cell encoded miRNAs, as expressed in a Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cell line (HEp-2+RSV-GFP)...
May 4, 2018: Virus Research
https://www.readbyqxmd.com/read/29733698/age-associated-increase-of-thyroid-hormone-receptor-%C3%AE-gene-promoter-methylation-coexists-with-decreased-gene-expression
#4
Eliza Pawlik-Pachucka, Monika Budzinska, Zofia Wicik, Anna Domaszewska-Szostek, Magdalena Owczarz, Malgorzata Roszkowska-Gancarz, Magdalena Gewartowska, Monika Puzianowska-Kuznicka
PURPOSE: It is not established if healthy aging of the thyroid axis is associated with alterations other than changes in hormone secretion. METHODS: The expression of thyroid hormone receptor β gene (THRB) was analyzed in peripheral blood mononuclear cells (PBMC) obtained from young, elderly, and long-lived individuals. The interaction between the 3'UTR of TRβ1 mRNA and selected miRNAs was measured using pmirGLO reporter vector. Methylation of the THRB CpG island was analyzed using methylation-sensitive restriction/RT-PCR and bisulfite sequencing methods...
May 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29731835/effect-of-mir-146a-5p-on-proliferation-and-metastasis-of-triple-negative-breast-cancer-via-regulation-of-sox5
#5
Chengshuai Si, Qiao Yu, Yufeng Yao
MicroRNA (miR)-146a-5p functions as a tumor suppressor in various types of cancer. However, the role of miR-146a-5p in the development of triple-negative breast cancer (TNBC) is unclear. The present study aimed to investigate the role of miR-146a-5p in TNBC. The expression level of miR-146a-5p in TNBC tissues and cell lines was initially detected using reverse transcription-quantitative polymerase chain reaction. To predict the target gene of miR-146a-5p, TargetScan software was used and a dual luciferase assay was performed to verify the prediction...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29715515/contribution-of-microrna-149-microrna-146a-and-microrna-196a2-snps-in-colorectal-cancer-risk-and-clinicopathological-features-in-tunisia
#6
Vera Chayeb, Sana Mahjoub, Hedia Zitouni, Hanene Jrah-Harzallah, Khadija Zouari, Rached Letaief, Touhami Mahjoub
BACKGROUND AND AIM: Colorectal cancer (CRC) is a worldwide leading cause of mortality. Genetic studies have associated single nucleotide polymorphisms in genes encoding microRNAs with CRC risk but results are mostly inconclusive across variable ethnicities. In this study, we investigated the association of hsa-mir-149 rs2292832 C/T, hsa-mir-146a rs2910164 G/C and hsa-mir-196a2 rs11614913 C/T and explored their roles in clinicopathological features of CRC progression in an Eastern Tunisian cohort...
April 28, 2018: Gene
https://www.readbyqxmd.com/read/29702211/mir-146a-5p-promotes-replication-of-infectious-bronchitis-virus-by-targeting-irak2-and-tnfrsf18
#7
Hui Liu, Xin Yang, Zhi-Kun Zhang, Wen-Cheng Zou, Hong-Ning Wang
Avian infectious bronchitis virus (IBV) is a coronavirus which infects chickens (Gallus gallus) of all ages and causes significant economic losses to the poultry industry worldwide. The present study aims to analyze the miRNAs related to pathogenicity of nephropathogenic IBVs. It was found that four miRNAs (miR-1454, miR-3538, miR-146a-5p and miR-215-5p) were related to the infection of virulent nephropathogenic IBV with transcript per million (TPM) > 500 and more than a 2-fold alteration. In vitro study results showed that the alterations of these four miRNAs were consistent with in vivo data...
April 24, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29702190/mirna-146a-promotes-chemotherapy-resistance-in-lung-cancer-cells-by-targeting-dna-damage-inducible-transcript-3-chop
#8
Wenfeng Tan, Yi Liao, Yang Qiu, Hongxiang Liu, Deli Tan, Tao Wu, Meng Tang, Shixin Zhang, Haidong Wang
The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to multidrug resistance in solid tumors is unknown. Here, we investigated CHOP expression in tumor tissues form 69 lung cancer patients, finding that deficient CHOP expression is associated with poor prognosis...
April 24, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29689091/higher-expression-of-mir-133b-is-associated-with-better-efficacy-of-erlotinib-as-the-second-or-third-line-in-non-small-cell-lung-cancer-patients
#9
Alessandra Bisagni, Maria Pagano, Sally Maramotti, Francesca Zanelli, Martina Bonacini, Elena Tagliavini, Luca Braglia, Massimiliano Paci, Andrea Mozzarelli, Stefania Croci
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (gefitinib, erlotinib and afatinib) are indicated as first-line therapy in patients with non-small cell lung cancer (NSCLC) whose tumors harbor activating mutations in the EGFR gene. Erlotinib is also used in second and third-line therapy for patients whose tumors have wild type EGFR but to date there are no validated biomarkers useful to identify which patients may benefit from this treatment. The expression level of four miRNAs: miR-133b, -146a, -7 and -21 which target EGFR was investigated by real-time PCR in tumor specimens from NSCLC patients treated with erlotinib administered as the second or third line...
2018: PloS One
https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#10
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 19, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29657293/mir-146-and-mir-155-two-key-modulators-of-immune-response-and-tumor-development
#11
REVIEW
Ugo Testa, Elvira Pelosi, Germana Castelli, Catherine Labbaye
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19-3 nucleotides in length, that negatively regulate protein coding gene transcripts' expression. miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors. In the present review, we have focused on the recent acquisitions about the key role played by miR-146a, miR-146b and miR-155 in the control of the immune system and in myeloid tumorigenesis...
June 26, 2017: Non-Coding RNA
https://www.readbyqxmd.com/read/29600898/specific-circulating-micrornas-display-dose-dependent-responses-to-variable-intensity-and-duration-of-endurance-exercise
#12
Anna Eden Ramos, Claire Lo, Leonard Estephan, Yi-Yin Tai, Ying Tang, Jingsi Zhao, Masataka Sugahara, John Gorcsan, Marcel G Brown, Daniel E Lieberman, Stephen Y Chan, Aaron Baggish
Circulating microRNAs (c-miRNAs) - plasma-based noncoding RNAs that control post-transcriptional gene expression - mediate processes that underlie phenotypic plasticity to exercise. The relationship and biologic relevance between c-miRNA expression and variable dose exercise exposure remain uncertain. We hypothesized that certain c-miRNAs respond to changes in exercise intensity and/or duration in a dose-dependent fashion. Muscle release of such c-miRNAs may then deplete intracellular stores, thus facilitating gene reprogramming and exercise adaptation...
March 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29594807/genetic-polymorphisms-in-mir-146a-mir-196a2-and-mir-125a-genes-and-its-association-in-prostate-cancer
#13
Mohan Damodaran, Solomon F D Paul, Vettriselvi Venkatesan
The increase in incidence of prostate cancer in the Indian Population stresses the need to identify genetic markers for susceptibility and prognosis. Recent studies show that microRNAs play an important role in tumorigenesis by altering proliferation, differentiation and cell death. Gene polymorphisms not only in promoter region but also within miRNA gene have been shown to affect expression. The present study was aimed to analyze the role of miR-146a, miR-196a2 and miR-125a gene polymorphisms in prostate cancer...
March 29, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29593734/experimental-demyelination-and-axonal-loss-are-reduced-in-microrna-146a-deficient-mice
#14
Nellie A Martin, Viktor Molnar, Gabor T Szilagyi, Maria L Elkjaer, Arkadiusz Nawrocki, Justyna Okarmus, Agnieszka Wlodarczyk, Eva K Thygesen, Miklos Palkovits, Ferenc Gallyas, Martin R Larsen, Hans Lassmann, Eirikur Benedikz, Trevor Owens, Asa F Svenningsen, Zsolt Illes
Background: The cuprizone (CPZ) model of multiple sclerosis (MS) was used to identify microRNAs (miRNAs) related to in vivo de- and remyelination. We further investigated the role of miR-146a in miR-146a-deficient (KO) mice: this miRNA is differentially expressed in MS lesions and promotes differentiation of oligodendrocyte precursor cells (OPCs) during remyelination, but its role has not been examined during demyelination. Methods: MicroRNAs were examined by Agilent Mouse miRNA Microarray in the corpus callosum during CPZ-induced demyelination and remyelination...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29590637/the-role-of-the-microrna-146a-complement-factor-h-interleukin-1%C3%AE-mediated-inflammatory-loop-circuit-in-the-perpetuate-inflammation-of-chronic-temporal-lobe-epilepsy
#15
Tao-Ran Li, Yan-Jie Jia, Chao Ma, Wen-Ying Qiu, Qun Wang, Xiao-Qiu Shao, Rui-Juan Lv
Increasing evidence indicates that neuroinflammation plays a crucial role in the pathogenesis of temporal lobe epilepsy (TLE). However, it is unclear how the perpetuate inflammation develops. Some recent studies have suggested the possible involvement of microRNA-146a (miR-146a) in the modulation of inflammatory signaling occurring in TLE. To understand how miR-146a modulates inflammatory signaling in TLE, we investigated the role of interleukin-1β (IL-1β), miR-146a and human complement factor H (CFH) in the perpetuate inflammation in rat models of chronic TLE and U251 cells...
March 23, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29589310/rt-qpcr-for-fecal-mature-microrna-quantification-and-validation
#16
Farid E Ahmed, Nancy C Ahmed, Mostafa M Gouda, Paul W Vos, Chris Bonnerup
By routinely and systematically being able to perform quantitative stem-loop reverse transcriptase (RT) followed by TaqMan® minor-groove binding (MGB) probe, real-time quantitative PCR analysis on exfoliated enriched colonocytes in stool, using human (Homo sapiens, hsa) micro(mi)RNAs to monitor changes of their expression at various stages of colorectal (CRC) progression, this method allows for the reliable and quantitative diagnostic screening of colon cancer (CC). Although the expression of some miRNA genes tested in tissue shows less variability in normal or cancerous patients than in stool, the noninvasive stool by itself is well suited for CC screening...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29587639/mir-146a-g-c-rs2910164-variation-in-south-african-indian-and-caucasian-patients-with-psoriatic-arthritis
#17
Ajesh B Maharaj, Pragalathan Naidoo, Terisha Ghazi, Naeem S Abdul, Shanel Dhani, Taskeen F Docrat, Prithiksha Ramkaran, Paul-Peter Tak, Niek de Vries, Anil A Chuturgoon
BACKGROUND: Psoriasis and psoriatic arthritis (PsA) are inflammatory associated autoimmune disorders. MicroRNA (miR)-146a plays a crucial role in regulating inflammation. A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA. In South Africa, psoriasis and PsA are extremely rare in the indigenous African population and most common in both the Indian and Caucasian population...
March 27, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29568399/ctbp1-and-metabolic-syndrome-induce-an-mrna-and-mirna-expression-profile-critical-for-breast-cancer-progression-and-metastasis
#18
Paula L Farré, Georgina D Scalise, Rocío B Duca, Guillermo N Dalton, Cintia Massillo, Juliana Porretti, Karen Graña, Kevin Gardner, Paola De Luca, Adriana De Siervi
Metastatic breast cancer (BrCa) is still one of the main causes of cancer death in women. Metabolic syndrome (MeS), a risk factor for BrCa, is associated to high grade tumors, increased metastasis and recurrence of this disease. C-terminal binding protein 1 (CTBP1) is a co-repressor of tumor suppressor genes that is activated by low NAD+ /NADH ratio. Previously, we demonstrated that CTBP1 hyperactivation by MeS increased tumor growth in MDA-MB-231-derived xenografts regulating several genes and miRNAs. In this work, our aim was to elucidate the role of CTBP1 and MeS in BrCa metastasis...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29562776/micrornas-of-equine-amniotic-mesenchymal-cell-derived-microvesicles-and-their-involvement-in-anti-inflammatory-processes
#19
Anna Lange-Consiglio, Barbara Lazzari, Claudia Perrini, Flavia Pizzi, Alessandra Stella, Fausto Cremonesi, Emanuele Capra
Cell-derived microvesicles (MVs) are a recently discovered mechanism of cell-to-cell communication. Our previous data show that MVs secreted by equine amniotic mesenchymal-derived cells (AMCs) are involved in downregulation of proinflammatory genes in lipopolysaccharide-stressed equine tendon and endometrial cells. The aim of the present study was to evaluate whether AMC-MVs contain selected microRNAs (miRNAs) involved in inflammation. Two pools of cells, derived from 3 amniotic membranes each, and their respective MVs were collected...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29544526/mice-with-mir-146a-deficiency-develop-severe-gouty-arthritis-via-dysregulation-of-traf-6-irak-1-and-nalp3-inflammasome
#20
Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-Shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou
BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. However, the role of miR-146a in the development of gout remains unknown. Here, we used miR-146a knockout (KO) mice to test miR-146a function in a monosodium urate (MSU)-induced gouty arthritis model...
March 15, 2018: Arthritis Research & Therapy
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