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https://www.readbyqxmd.com/read/28636281/aryl-and-heteroaryl-substituted-phenylalanines-as-ampa-receptor-ligands
#1
Ewa Szymańska, Paulina Chałupnik, Tommy N Johansen, Birgitte Nielsen, Ana Maria Cuñado Moral, Darryl S Pickering, Anna Więckowska, Katarzyna Kieć-Kononowicz
A series of racemic unnatural amino acids was rationally designed on the basis of recently published X-ray structures of the GluA2 LBD with bound phenylalanine-based antagonists. Twelve new diaryl- or aryl/heteroaryl-substituted phenylalanine derivatives were synthesized and evaluated in vitro in radioligand binding assays at native rat ionotropic glutamate receptors. The most interesting compound in this series, (RS)-2-amino-3-(3'-hydroxy-5-(1H-pyrazol-4-yl)-[1,1'-biphenyl]-3-yl)propanoic acid 7e, showed the binding affinity of 4...
June 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28636260/lichenoid-keratosis-is-frequently-misdiagnosed-as-basal-cell-carcinoma
#2
D Maor, C Ondhia, L L Yu, J J Chan
Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis...
June 21, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28636231/orchestration-at-the-beginning-mitosis-in-sea-urchin-embryo
#3
Giselle A Abruzzese, Nae Tanpradit, Renata S Tavares
Development of multicellular organisms is driven by a series of mitotic divisions after fertilization. Total cytoplasmic volume does not increase during this process, resulting in an increasing number of smaller daughter cells. Cell divisions are initially synchronous in an early embryo, but this ends at the 16-cell stage in the sea urchin. Orchesterated mitosis does, however, continue in subpopulations via the coordination of two different processes: karyokinesis and cytokinesis. Part of this asynchrony is due to the differentiation of lineages...
June 21, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28636204/aerobic-exercise-training-for-adults-with-fibromyalgia
#4
REVIEW
Julia Bidonde, Angela J Busch, Candice L Schachter, Tom J Overend, Soo Y Kim, Suelen M Góes, Catherine Boden, Heather Ja Foulds
BACKGROUND: Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for people with fibromyalgia that will replace the "Exercise for treating fibromyalgia syndrome" review first published in 2002. OBJECTIVES: • To evaluate the benefits and harms of aerobic exercise training for adults with fibromyalgia• To assess the following specific comparisons ० Aerobic versus control conditions (eg, treatment as usual, wait list control, physical activity as usual) ० Aerobic versus aerobic interventions (eg, running vs brisk walking) ० Aerobic versus non-exercise interventions (eg, medications, education) We did not assess specific comparisons involving aerobic exercise versus other exercise interventions (eg, resistance exercise, aquatic exercise, flexibility exercise, mixed exercise)...
June 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28636189/discovery-of-alkyl-bis-oxy-dibenzimidamide-derivatives-as-novel-protein-arginine-methyltransferase-1-prmt1-inhibitors
#5
Wei-Yao Zhang, Wen-Chao Lu, Hao Jiang, Zheng-Bing Lv, Yi-Qian Xie, Fu-Lin Lian, Zhong-Jie Liang, Yu-Xi Jiang, Da-Jin Wang, Cheng Luo, Jia Jin, Fei Ye
Protein arginine methylation, a post-translational modification critical for a variety of biological processes, is catalyzed by protein arginine N-methyltransferases (PRMTs). In particular, PRMT1 is responsible for over 85% of the arginine methylation in mammalian cells. Dysregulation of PRMT1 is involved in diverse pathological diseases including cancers. However, most current PRMT1inhibitors are lack of specificity, efficacy, and bioavailability. Herein, a series of alkyl bis(oxy)dibenzimidamide derivatives were identified as selective PRMT1 inhibitors...
June 21, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28636180/characterization-of-herpes-simplex-virus-infections-seen-in-the-pediatric-dermatology-office
#6
Julia K Gittler, Euphemia W Mu, Seth J Orlow
BACKGROUND/OBJECTIVES: Atypical and severe clinical manifestations of primary and recurrent herpes simplex virus (HSV) infections may present to a pediatric dermatologist for evaluation. The purpose of this study was to characterize the clinical features of the population diagnosed with HSV referred to a pediatric dermatology office. METHODS: This retrospective case series examined patients diagnosed with HSV in a pediatric dermatology practice at an academic medical center from 2005 to 2015...
June 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28636122/hidradenitis-suppurativa-in-down-syndrome-a-case-series
#7
Issam Hamadah, Mansoor Haider, Muzamil Chisti, Yousef Binamer
BACKGROUND/OBJECTIVES: Many dermatologic and systemic diseases have been reported in association with hidradenitis suppurativa, but its association with Down syndrome is rarely mentioned in the literature. The objective of the current study was to assess the frequency of hidradenitis suppurativa in patients with Down syndrome who visited our clinic over 4 years. METHODS: We recorded the presenting complaints and dermatologic problems of patients with Down syndrome who visited our clinic from January 2011 to December 2014...
June 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28636058/percutaneous-tibial-physeal-fracture-repair-in-small-animals-technique-and-17-cases
#8
Dirsko J F von Pfeil, Mathieu Glassman, Meaghan Ropski
OBJECTIVES: To retrospectively describe cases treated via percutaneous tibial physeal fracture repair (PTPFR), using intra-operative fluoroscopy (IFL) or digital radiography (DR). To describe a technique ("spiking"), used to treat tibial tuberosity avulsion fractures. METHODS: Clinical data of 14 dogs and three cats were included. The "spiking" technique was described. RESULTS: Intra-operative fluoroscopy (n = 11) and DR (n = 6) were successfully used in 11 tibial tuberosity avulsion fractures, one combined proximal physeal and tibial tuberosity avulsion fracture, and five distal tibial/fibular physeal fractures...
June 21, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28636046/lead-ii-soaps-crystal-structures-polymorphism-and-solid-and-liquid-mesophases
#9
F J Martínez-Casado, M Ramos-Riesco, J A Rodríguez-Cheda, M I Redondo-Yélamos, L Garrido, A Fernández-Martínez, J García-Barriocanal, I da Silva, M Durán-Olivencia, A Poulain
The long-chain members of the lead(ii) alkanoate series or soaps, from octanoate to octadecanoate, have been thoroughly characterized by means of XRD, PDF analysis, DSC, FTIR, ssNMR and other techniques, in all their phases and mesophases. The crystal structures at room temperature of all of the members of the series are now solved, showing the existence of two polymorphic forms in the room temperature crystal phase, different to short and long-chain members. Only nonanoate and decanoate present both forms, and this polymorphism is proven to be monotropic...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28635869/-the-topical-problems-of-expert-mistakes-and-evaluation-of-the-quality-of-forensic-medical-expertises-based-on-the-analysis-of-the-reports-published-in-the-journal-sudebno-meditsinskaya-ekspertiza-forensic-medical-expertise-during-the-period-from-1958-till
#10
L A Shmarov
The objective of the present study was the thematic analysis of the reports published in the journal 'Sudebno-meditsinskaya ekspertiza' (Forensic Medical Expertise) during the period from 1958 till 2015 that contain the authors' characteristics of the mistakes made in connection with the performance of various forms of forensic medical expertise with special reference to their quality and time schedules. A total of 268 issues of the journal were looked through from which 25 articles were selected dealing with the analysis of expert mistakes...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28635643/a-multi-wavelength-opto-electronic-patch-sensor-to-effectively-detect-physiological-changes-against-human-skin-types
#11
Liangwen Yan, Sijung Hu, Abdullah Alzahrani, Samah Alharbi, Panagiotis Blanos
Different skin pigments among various ethnic group people have an impact on spectrometric illumination on skin surface. To effectively capture photoplethysmographic (PPG) signals, a multi-wavelength opto-electronic patch sensor (OEPS) together with a schematic architecture of electronics were developed to overcome the drawback of present PPG sensor. To perform a better in vivo physiological measurement against skin pigments, optimal illuminations in OEPS, whose wavelength is compatible with a specific skin type, were optimized to capture a reliable physiological sign of heart rate (HR)...
June 21, 2017: Biosensors
https://www.readbyqxmd.com/read/28635627/molecular-quantum-similarity-chemical-reactivity-and-database-screening-of-3d-pharmacophores-of-the-protein-kinases-a-b-and-g-from-mycobacterium-tuberculosis
#12
Alejandro Morales-Bayuelo
Mycobacterium tuberculosis remains one of the world's most devastating pathogens. For this reason, we developed a study involving 3D pharmacophore searching, selectivity analysis and database screening for a series of anti-tuberculosis compounds, associated with the protein kinases A, B, and G. This theoretical study is expected to shed some light onto some molecular aspects that could contribute to the knowledge of the molecular mechanics behind interactions of these compounds, with anti-tuberculosis activity...
June 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28635538/clomipramine-trial-for-treatment-resistant-persistent-genital-arousal-disorder-a-case-series
#13
Ejder Akgun Yildirim, Munevver Hacioglu Yildirim, Elif Carpar, Irmak Sarac
INTRODUCTION: Treatment of persistent genital arousal disorder (PGAD), as a chronic and disabling condition, implicates substantial compelling complexities. METHODS: In this case series, seven women diagnosed with PGAD who were referred to the Sexual Dysfunction Unit of Psychotherapy Outpatient Clinic of Bakirkoy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey between 2006 and 2009 were included. All patients were previously resistant to other antidepressants, antipsychotics and antiepileptics...
March 3, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28635519/the-elicitor-protein-ases-induces-a-sar-response-accompanied-by-systemic-microbursts-and-micro-hrs-in-fragaria-ananassa
#14
Verónica Hael Conrad, Silvia Marisa Perato, Marta Elena Arias, Martín Gustavo Martínez Zamora, Pía de Los Ángeles Di Peto, Gustavo Gabriel Martos, Atilio Pedro Castagnaro, Juan Carlos Diaz-Ricci, Nadia Regina Chalfoun
The elicitor AsES (Acremonium strictum Elicitor Subtilisin) is a 34 KDa subtilisin-like protein secreted by the opportunistic fungus Acremonium strictum. AsES activates the innate immunity and confers resistance against anthracnose and grey mold diseases in strawberry plants (Fragaria x ananassa Duch.) and the last disease also in Arabidopsis. In the present work, we show that upon AsES recognition, a cascade of defense responses is activated, including: calcium influx, biphasic oxidative burst (O2(.-) and H2O2), HR response, accumulation of autofluorescent compounds, cell wall reinforcement with callose and lignin deposition, salicylic acid accumulation, and expression of defense-related genes such as FaPR1, FaPG1, FaMYB30, FaRBOH-D, FaRBOH-F, FaCHI23 and FaFLS...
June 21, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28635518/complete-resolution-of-mycosis-fungoides-tumors-with-imiquimod-5-cream-a-case-series
#15
Daniel J Lewis, Yevgeniya A Byekova, Drew A Emge, Madeleine Duvic
OBJECTIVE: To demonstrate the clinical efficacy of topical 5% imiquimod for mycosis fungoides (MF) tumors. BACKGROUND: Treatment of tumor-stage MF represents a therapeutic challenge because of a limited number of effective topical therapies. Single tumors can be treated with localized radiation but may recur. Systemic therapies are also an option but are associated with serious adverse effects. Imiquimod is a topical agent whose efficacy has been documented in treating MF patches and plaques as well as one case of tumor-stage disease...
March 2, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28635425/multimodal-imaging-in-cabp4-related-retinopathy
#16
Patrik Schatz, Maram E A Abdalla Elsayed, Arif O Khan
PURPOSE: Multimodal imaging has not been documented for CABP4-related retinopathy. In this study, we describe optical coherence tomography (OCT) and fundus autofluorescence findings for five genetically confirmed cases. METHODS: Retrospective case series. RESULTS: Four patients with the previously described homozygous Saudi CABP4 founder mutation c.81_82insA (p.Pro28ThrfsX44) and one patient with the homozygous mutation c.1A>G (p.Met1?) in CABP4 were examined...
March 1, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28635409/confronting-infertility-in-iranian-clients-a-grounded-theory
#17
Mitra Zandi, Eesa Mohammadi, Zohreh Vanaki, Marziyeh Shiva, Narges Bagheri Lankarani, Faezeh Zarei
The present study examined how infertile Iranian clients confront infertility. Research on infertility has confirmed the significance of a socio-cultural context in the formation of responses to infertility. This study used the grounded theory approach to explore the experiences of infertile individuals presenting at the Royan Institute in Iran from October 2013 to September 2014. Clients with infertility of at least two years in duration were recruited using purposive sampling followed by theoretical sampling...
February 10, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28635373/relative-risk-of-hemorrhage-during-pregnancy-in-patients-with-brain-arteriovenous-malformations
#18
Janneke van Beijnum, Tim Wilkinson, Heather J Whitaker, Johanna G van der Bom, Ale Algra, W Peter Vandertop, René van den Berg, Patrick A Brouwer, Gabriël Je Rinkel, L Jaap Kappelle, Rustam Al-Shahi Salman, Catharina Jm Klijn
Background It is unclear whether the risk of bleeding from brain arteriovenous malformations is higher during pregnancy, delivery, or puerperium. We compared occurrence of brain arteriovenous malformation hemorrhage in women during this period with occurrence of hemorrhage outside this period during their fertile years. Methods We included all women with ruptured brain arteriovenous malformations (16-41 years) from a retrospective database of patients with brain arteriovenous malformations in four Dutch university hospitals (n = 95) and from the population-based Scottish Audit of Intracranial Vascular Malformations (n = 44)...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28635343/primary-psychopathy-and-alcohol-pathology-in-college-students-the-role-of-protective-behavioral-strategies
#19
Matthew P Kramer, Brittany L Stevenson, Robert D Dvorak
OVERVIEW: Though not an official diagnosis, psychopathy has become an important area of research due to the litany of deleterious outcomes associated with this aspect of temperament. Psychopathy is composed of primary and secondary traits. Research consistently links psychopathy to alcohol pathology, though often only via secondary traits which are comprised of intractable aspects of behavior (e.g., poor impulse control). In contrast, primary psychopathy is comprised of behaviors that can be learned and thus may be more malleable (i...
February 13, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28634762/rapid-preconcentration-of-viable-bacteria-using-magnetic-ionic-liquids-for-pcr-amplification-and-culture-based-diagnostics
#20
Kevin D Clark, Jeffrey A Purslow, Stephen A Pierson, Omprakash Nacham, Jared L Anderson
In this study, a series of magnetic ionic liquids (MILs) were investigated for the extraction and preconcentration of bacteria from aqueous samples. By dispersing small volumes (e.g., 15 μL) of MIL within an aqueous cell suspension, bacteria were rapidly extracted and isolated using a magnetic field. Of the seven hydrophobic MILs examined, the trihexyl(tetradecyl)phosphonium Ni(II) hexafluoroacetylacetonate ([P66614(+)][Ni(hfacac)3(-)]) MIL exhibited the greatest enrichment of viable Escherichia coli K12 when coupled with microbiological culture as the detection method...
June 20, 2017: Analytical and Bioanalytical Chemistry
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