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https://www.readbyqxmd.com/read/28934798/clinical-course-of-cervical-percutaneous-epidural-neuroplasty-in-single-level-cervical-disc-disease-with-12-month-follow-up
#1
Chang Hyun Oh, Gyu Yeul Ji, Dong Ah Shin, Pyung Goo Cho, Seung Hwan Yoon
BACKGROUND: Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after PEN in cervical disc disease is not well-documented. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cervical PEN for single-level cervical disc disease...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934750/frontotemporal-dementia-caused-by-the-p301l-mutation-in-the-mapt-gene-clinicopathological-features-of-13-cases-from-the-same-geographical-origin-in-barcelona-spain
#2
Sergi Borrego-Écija, Joana Morgado, Leire Palencia-Madrid, Oriol Grau-Rivera, Ramón Reñé, Isabel Hernández, Consuelo Almenar, Mircea Balasa, Anna Antonell, José Luis Molinuevo, Albert Lladó, Marian Martínez de Pancorbo, Ellen Gelpi, Raquel Sánchez-Valle
BACKGROUND/AIMS: We identified and studied 13 patients carrying the P301L mutation in the MAPT gene from the same area (Baix Llobregat County) in Barcelona, Spain. METHODS: The demographic and clinical features were reviewed retrospectively. Detailed neuropathological characterization was obtained in 9 subjects. To investigate the origin of the P301L mutation in these families, 20 single nucleotide polymorphisms (SNPs) in the MAPT gene were analyzed. RESULTS: The mean age at disease onset was 51 years and the mean disease duration was 7 years...
September 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28934674/managing-for-climate-change-on-protected-areas-an-adaptive-management-decision-making-framework
#3
Sherri L Tanner-McAllister, Jonathan Rhodes, Marc Hockings
Current protected area management is becoming more challenging with advancing climate change and current park management techniques may not be adequate to adapt for effective management into the future. The framework presented here provides an adaptive management decision making process to assist protected area managers with adapting on-park management to climate change. The framework sets out a 4 step process. One, a good understanding of the park's context within climate change. Secondly, a thorough understanding of the park management systems including governance, planning and management systems...
September 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934654/a-case-study-of-air-quality-pesticides-and-odorous-phytochemicals-on-kauai-hawaii-usa
#4
Jun Wang, Robert Boesch, Qing X Li
This study was conducted after a series of incidences occurred at Waimea Canyon Middle School on Kauai, Hawaii. Some students and staff members exhibited symptoms such as throat irritation, tearing, and dizziness. These symptoms could be associated with natural causes or human activities, which include exposures to pesticides and odorous phytochemicals. At the time of the occurrences, Cleome gynandra (known locally as stinkweed) was growing in the fields near the school and might be a potential cause of the reported symptoms...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28934626/stereoselective-sialylation-with-o-trifluoroacetylated-thiosialosides-hydrogen-bonding-involved
#5
Nikita M Podvalnyy, Nelly N Malysheva, Maria V Panova, Alexander I Zinin, Alexander O Chizhov, Anna V Orlova, Leonid O Kononov
A series of novel sialyl donors containing O-trifluoroacetyl (TFA) groups at various positions was synthesized. The choice of protecting groups in sialyl donors was based on hypothesis that variations in ability of different acyl groups to act as hydrogen bond acceptors would influence the supramolecular structure of reaction mixture (solution structure), hence the outcome of sialylation. These glycosyl donors were examined in the model glycosylation of the primary hydroxyl group of 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose in comparison with sialyl donors without O-TFA groups...
September 8, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28934609/quantitative-measurement-of-sodium-polystyrene-sulfonate-adsorption-onto-ctab-capped-gold-nanoparticles-reveals-hard-and-soft-coronas
#6
Celina M Harris, Savannah G Miller, Kurt Andresen, Lucas B Thompson
Accumulated evidence indicates that nanoparticle behavior in complex biological environments strongly depends on the nanoparticles' surface chemistry. A common way to modify nanoparticles is to deposit oppositely charged molecules on the surfaces in a Layer-by-Layer fashion to build up thin films of polymers. While this polymer coating is a well-developed technique, the quantification of polymers deposited and physical mechanism of polymer deposition remain relatively unstudied. In this work CTAB capped gold nanoparticles, synthesized in a flow reactor, are coated with sodium polystyrene sulfonate and purified through a series of equilibrium dialysis steps...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28934541/contact-dermatitis-reaction-to-2-octyl-cyanoacrylate-following-3-orthopedic-procedures
#7
Nicholas H Lake, Brian T Barlow, James E Toledano, Johannah Valentine, Lucas S McDonald
Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone...
September 21, 2017: Orthopedics
https://www.readbyqxmd.com/read/28934448/cervical-spine-deformity-part-2-management-algorithm-and-anterior-techniques
#8
Lee A Tan, K Daniel Riew, Vincent C Traynelis
A sound operative plan based on solid understanding of the pathology and biomechanics is the most important part of cervical deformity correction. Many different surgical options exist for operative management of cervical spine deformities. However, selecting the correct approach that ensures the optimal clinical outcome can be challenging and often controversial. In Part 2 of this three-part review series, we discuss the pre-operative planning, management algorithm, and anterior surgical techniques for cervical deformity correction...
October 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28934398/messenger-rna-processing-is-altered-in-autosomal-dominant-leukodystrophy
#9
Anna Bartoletti-Stella, Laura Gasparini, Caterina Giacomini, Patrizia Corrado, Rossana Terlizzi, Elisa Giorgio, Pamela Magini, Marco Seri, Agostino Baruzzi, Piero Parchi, Alfredo Brusco, Pietro Cortelli, Sabina Capellari
No abstract text is available yet for this article.
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28934355/study-of-myelin-structure-changes-during-the-nerve-fibers-demyelination
#10
Natalia N Rodionova, Elvin S Allakhverdiev, Georgy V Maksimov
Raman, NMR and EPR spectroscopy and electrophysiology methods were used to investigate the excitability and the packaging of myelin lipid layers and its viscosity during nerve exposure to pronase E. It was established that during exposure of nerve to pronase E the action potential (AP) conduction velocity and the Schwann cell (SC) (or myelin) water ordering increases, but the nerve myelin refractive index and internode incisions numbers decrease. This effect included two periods-short- and long-time period, probably, because the first one depends on SC protein changes and the second one-on the nerve fiber internode demyelination...
2017: PloS One
https://www.readbyqxmd.com/read/28934327/a-novel-miniature-in-line-load-cell-to-measure-in-situ-tensile-forces-in-the-tibialis-anterior-tendon-of-rats
#11
Martin Schmoll, Ewald Unger, Manfred Bijak, Martin Stoiber, Hermann Lanmüller, Jonathan Charles Jarvis
Direct measurements of muscular forces usually require a substantial rearrangement of the biomechanical system. To circumvent this problem, various indirect techniques have been used in the past. We introduce a novel direct method, using a lightweight (~0.5 g) miniature (3 x 3 x 7 mm) in-line load-cell to measure tension in the tibialis anterior tendon of rats. A linear motor was used to produce force-profiles to assess linearity, step-response, hysteresis and frequency behavior under controlled conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28934325/first-report-of-changes-in-leukocyte-morphology-in-response-to-inflammatory-conditions-in-asian-and-african-elephants-elephas-maximus-and-loxodonta-africana
#12
Nicole I Stacy, Ramiro Isaza, Ellen Wiedner
Although the hematology of healthy elephants has been well-described, published information on hematological changes during disease is limited. The objective of this study was to describe qualitative morphological changes in the leukocytes of Asian and African elephants (Elephas maximus and Loxodonta africana) diagnosed with a variety of inflammatory conditions. Twenty-five of 27 elephants had morphological changes in their leukocytes, although only 16 of these had a concurrent inflammatory leukogram. Morphological changes included heterophil left-shifting with or without concurrent dysgranulopoiesis, toxicity, or hypersegmentation, reactive lymphocytes, plasma cells, and/or vacuolated monocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28934212/outcome-of-papillary-versus-clear-cell-renal-cell-carcinoma-varies-significantly-in-non-metastatic-disease
#13
Nina Wagener, Dominic Edelmann, Axel Benner, Richard Zigeuner, Hendrik Borgmann, Ingmar Wolff, Laura M Krabbe, Mireia Musquera, Paolo Dell'Oglio, Umberto Capitanio, Tobias Klatte, Luca Cindolo, Matthias May, Sabine D Brookman-May
Renal cell carcinoma (RCC) comprises a heterogenous group of tumors. Traditionally, papillary RCC (pRCC) is associated with a favorable outcome compared to clear cell RCC (ccRCC), while other series report equivalent or worse prognosis. In this paper we comparatively evaluate outcome of pRCC versus ccRCC in two large multi-institutional databases (cohort study), including distribution of pRCC subtypes 1 and 2. Retrospective data of 1,943 surgically treated pRCC patients from 17 European/ North American centers between 1984-2015 were compared to 5,600 ccRCC patients from a database comprising 11 European/ North American centers (1984-2011)...
2017: PloS One
https://www.readbyqxmd.com/read/28934145/spectroscopic-electrochemical-and-dft-studies-of-phosphorescent-homoleptic-cyclometalated-iridium-iii-complexes-based-on-substituted-4-fluorophenylvinyl-and-4-methoxyphenylvinylquinolines
#14
Adewale O Adeloye, Malose J Mphahlele, Abolanle S Adekunle, Lydia Rhyman, Ponnadurai Ramasami
This study reports the synthesis and comparative investigation of the substituent effects of a new series of highly luminescent homoleptic tris-cyclometalated iridium(III) complexes of the type [Ir(N(˄)C)₃]. These are based on two ligand type derivatives comprising of 4-fluorophenylvinylquinolines and 4-methoxyphenylvinylquinolines with electron-donating and/or electron-withdrawing groups as aryl substituents at 2-position. The structures of the ligands and their complexes were characterized by means of FT-IR, UV-Vis and NMR spectrometry complemented with photoluminescence and cyclic voltammetry...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28934074/routine-assessment-of-unmet-needs-in-individuals-with-advanced-cancer-and-their-caregivers-a-qualitative-study-of-the-palliative-care-needs-assessment-tool-pc-nat
#15
Sylvie Lambert, Afaf Girgis, Thomas Bellamy
PURPOSE: To examine (a) approaches used by oncologists to administer the Palliative Care Needs Assessment Tool (PC-NAT) in consultations with patients with advanced cancer and their caregivers, (b) potential of this tool to facilitate discussion of psychosocial issues, and (c) whether use of the tool alters the length of consultations. DESIGN: A qualitative analysis was undertaken of audiotaped, outpatient consultations. SAMPLE AND METHODS: 20 individuals with advanced cancer and their caregivers who participated in an interrupted time series study of the impact of the systematic utilisation of the Palliative Care Needs Assessment Tool (PC-NAT) had a total of 48 consultations audiotaped...
September 21, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28933981/tfpi2as1-a-novel-lncrna-that-inhibits-cell-proliferation-and-migration-in-lung-cancer
#16
Shenglan Gao, Ziying Lin, Chunyan Li, Yahong Wang, Lawei Yang, Baoan Zou, Jie Chen, Jianwen Li, Zeqing Song, Gang Liu
Accumulating evidence demonstrates that a series of differentially expressed lncRNAs is important in tumorigenesis. However, the function of many of the lncRNAs in lung cancer remains elusive. In the present study, we used microarray analysis to identify lncRNAs that are dysregulated in non-small-cell lung cancer (NSCLC) as compared with normal tissues. Among the dysregulated lncRNAs, we identified TFPI2AS1, an antisense transcript of the tumor suppressor TFPI2 (tissue factor pathway inhibitor 2). TFPI2AS1 was shown to be markedly upregulated in NSCLC patient tumors as compared to paired non-tumor samples...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933907/generating-lies-produces-lower-memory-predictions-and-higher-memory-performance-than-telling-the-truth-evidence-for-a-metacognitive-illusion
#17
Miri Besken
Manipulations that induce disfluency during encoding generally produce lower memory predictions for the disfluent condition than for the fluent condition. Similar to other manipulations of disfluency, generating lies takes longer and requires more mental effort than does telling the truth; hence, a manipulation of lie generation might produce patterns similar to other types of fluency for memory predictions. The current study systematically investigates the effect of a lie-generation manipulation on both actual and predicted memory performance...
September 21, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28933868/electronic-structure-and-stability-of-b12x12-2-x-f-at-a-combined-photoelectron-spectroscopic-and-theoretical-study
#18
Jonas Warneke, Gao-Lei Hou, Edoardo Aprà, Carsten Jenne, Zheng Yang, Zhengbo Qin, Karol Kowalski, Xue-Bin Wang, Sotiris S Xantheas
The stability and electron loss process of numerous Multiply Charged Anions (MCAs) have been traditionally explained in terms of the classical Coulomb interaction between spatially separated charged groups. An understanding of these processes in MCAs with not well-separated excess charges is still lacking. We report the surprising properties and physical behavior of [B12X12]2-, X = F, Cl, Br, I, At, which are MCAs with not well-separated excess charges and cannot be described by the prevailing classical picture...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933858/energy-gap-law-for-exciton-dynamics-in-gold-cluster-molecules
#19
Kyuju Kwak, Viraj Dhanushka Thanthirige, Kyunglim Pyo, Dongil Lee, Guda Ramakrishna
The energy gap law relates the nonradiative decay rate to the energy gap separating the ground and excited states. Here we report that the energy gap law can be applied to exciton dynamics in gold cluster molecules. Size-dependent electrochemical and optical properties were investigated for a series of hexanethiolate-protected gold clusters ranging from Au25 to Au333. Voltammetric studies reveal that the highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gaps of these clusters decrease with increasing cluster size...
September 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28933853/exchange-hole-dipole-dispersion-model-for-accurate-energy-ranking-in-molecular-crystal-structure-prediction-ii-non-planar-molecules
#20
Sarah R Whittleton, Alberto Otero-de-la-Roza, Erin R Johnson
The crystal structure prediction (CSP) of a given compound from its molecular diagram is a fundamental challenge in computational chemistry with implications in relevant technological fields. A key component of CSP is the method to calculate the lattice energy of a crystal, which allows the ranking of candidate structures. This work is the second part of our investigation to assess the potential of the exchange-hole dipole moment dispersion (XDM) model for crystal structure prediction. In this article, we study the relatively large, non-planar, mostly flexible molecules in the first five blind tests held by the Cambridge Crystallographic Data Centre...
September 21, 2017: Journal of Chemical Theory and Computation
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