keyword
https://read.qxmd.com/read/38536963/affinity-tagged-smad1-and-smad5-mouse-lines-reveal-transcriptional-reprogramming-mechanisms-during-early-pregnancy
#21
JOURNAL ARTICLE
Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin Matzuk
Endometrial decidualization, a prerequisite for successful pregnancies, relies on transcriptional reprogramming driven by progesterone receptor (PR) and bone morphogenetic protein (BMP)-SMAD1/SMAD5 signaling pathways. Despite their critical roles in early pregnancy, how these pathways intersect in reprogramming the endometrium into a receptive state remains unclear. To define how SMAD1 and/or SMAD5 integrate BMP signaling in the uterus during early pregnancy, we generated two novel transgenic mouse lines with affinity tags inserted into the endogenous SMAD1 and SMAD5 loci ( Smad1HA/HA and Smad5PA/PA )...
March 27, 2024: ELife
https://read.qxmd.com/read/38536956/integrated-in-situ-fabrication-of-cuo-nanorod-decorated-polymer-membranes-for-the-catalytic-flow-through-reduction-of-p-nitrophenol
#22
JOURNAL ARTICLE
S Amir H Hesaraki, Oleg Prymak, Markus Heidelmann, Mathias Ulbricht, Lukas Fischer
We developed a novel method to fabricate copper nanorods in situ in a poly(ether sulfone) (15 wt %) casting solution by a sonochemical reduction of Cu2+ ions with NaBH4 . The main twist is the addition of ethanol to remove excess NaBH4 through Cu(0) catalyzed ethanolysis. This enabled the direct use of the resulting copper-containing casting dispersions for membrane preparation by liquid nonsolvent-induced phase separation and led to full utilization of the copper source, generating zero metal waste. We characterized the copper nanorods as presented in the membranes via scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and UV/vis spectroscopy...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38536951/attention-deficit-hyperactivity-disorder-in-children-ages-5-17-years-united-states-2020-2022
#23
JOURNAL ARTICLE
Cynthia Reuben, Nazik Elgaddal
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common mental disorders of childhood (1). It is characterized by a pattern of inattention, impulsivity, or hyperactivity that leads to functional impairment experienced in multiple settings (2). Symptoms of ADHD occur during childhood, and many children continue to have symptoms and impairment through adolescence and into adulthood (3). This report describes the percentage of children and adolescents ages 5-17 years who had ever been diagnosed with ADHD from the 2020-2022 National Health Interview Survey (NHIS)...
March 2024: NCHS Data Brief
https://read.qxmd.com/read/38536948/control-etched-ti-3-c-2-t-x-mxene-nanosheets-for-a-low-voltage-operating-flexible-memristor-for-efficient-neuromorphic-computation
#24
JOURNAL ARTICLE
Jeny Gosai, Mansi Patel, Lingli Liu, Aziz Lokhandwala, Parth Thakkar, Mun Yin Chee, Muskan Jain, Wen Siang Lew, Nitin Chaudhari, Ankur Solanki
Hardware neural networks with mechanical flexibility are promising next-generation computing systems for smart wearable electronics. Overcoming the challenge of developing a fully synaptic plastic network, we demonstrate a low-operating-voltage PET/ITO/p-MXene/Ag flexible memristor device by controlling the etching of aluminum metal ions in Ti3 C2 T x MXene. The presence of a small fraction of Al ions in partially etched MXene (p-Ti3 C2 T x ) significantly suppresses the operating voltage to 1 V compared to 7 V from fully Al etched MXene (f-Ti3 C2 T x )-based devices...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38536947/layer-number-dependent-magnetism-in-the-co-doped-van-der-waals-ferromagnet-fe-3-gate-2
#25
JOURNAL ARTICLE
Mingjie Wang, Kejia Zhu, Bin Lei, Yazhou Deng, Tao Hu, Dongsheng Song, Haifeng Du, Mingliang Tian, Ziji Xiang, Tao Wu, Xianhui Chen
Recently, van der Waals (vdW) antiferromagnets have been proposed to be crucial for spintronics due to their favorable properties compared to ferromagnets, including robustness against magnetic perturbation and high frequencies of spin dynamics. High-performance and energy-efficient spin functionalities often depend on the current-driven manipulation and detection of spin states, highlighting the significance of two-dimensional metallic antiferromagnets, which have not been much explored due to the lack of suitable materials...
March 27, 2024: Nano Letters
https://read.qxmd.com/read/38536928/bond-length-dependence-of-attosecond-ionization-delays-in-o-2-arising-from-electron-correlation-to-a-shape-resonance
#26
JOURNAL ARTICLE
Daniel Hammerland, Thomas Berglitsch, Pengju Zhang, Tran Trung Luu, Kiyoshi Ueda, Robert R Lucchese, Hans Jakob Wörner
We experimentally and theoretically demonstrate that electron correlation can cause the bond-length sensitivity of a shape resonance to induce an unexpected vibrational state-dependent ionization delay in a nonresonant channel. This discovery was enabled by a high-resolution attosecond-interferometry experiment based on a 400-nm driving and dressing wavelength. The short-wavelength driver results in a 6.2-electron volt separation between harmonics, markedly reducing the spectral overlap in the measured interferogram...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536902/human-robot-facial-coexpression
#27
JOURNAL ARTICLE
Yuhang Hu, Boyuan Chen, Jiong Lin, Yunzhe Wang, Yingke Wang, Cameron Mehlman, Hod Lipson
Large language models are enabling rapid progress in robotic verbal communication, but nonverbal communication is not keeping pace. Physical humanoid robots struggle to express and communicate using facial movement, relying primarily on voice. The challenge is twofold: First, the actuation of an expressively versatile robotic face is mechanically challenging. A second challenge is knowing what expression to generate so that the robot appears natural, timely, and genuine. Here, we propose that both barriers can be alleviated by training a robot to anticipate future facial expressions and execute them simultaneously with a human...
March 27, 2024: Science Robotics
https://read.qxmd.com/read/38536894/the-effects-of-dental-hygienist-autonomy-on-dental-care-utilization
#28
JOURNAL ARTICLE
Jie Chen, Chad D Meyerhoefer, Edward J Timmons
We investigate the effects of regulations governing the practice autonomy of dental hygienists on dental care use with the 2001-2014 Medical Expenditure Panel Survey. We measure the strength of autonomy regulations by extending the Dental Hygiene Professional Practice Index to the years 2001-2014, allowing us to capture changes in regulations within states over time. Using a difference-in-differences framework applied to selected states, we find that relaxing supervision requirements to provide dental hygienists moderate autonomy results in an increase in total dental visits due to greater use of preventive dental care...
March 27, 2024: Health Economics
https://read.qxmd.com/read/38536874/gray-whale-eschrichtius-robustus-post-mortem-findings-from-december-2018-through-2021-during-the-unusual-mortality-event-in-the-eastern-north-pacific
#29
JOURNAL ARTICLE
Stephen Raverty, Pádraig Duignan, Denise Greig, Jessica L Huggins, Kathy Burek Huntington, Michael Garner, John Calambokidis, Paul Cottrell, Kerri Danil, Dalin D'Alessandro, Deborah Duffield, Moe Flannery, Frances Md Gulland, Barbie Halaska, Dyanna M Lambourn, Taylor Lehnhart, Jorge Urbán R, Teri Rowles, James Rice, Kate Savage, Kristin Wilkinson, Justin Greenman, Justin Viezbicke, Brendan Cottrell, P Dawn Goley, Maggie Martinez, Deborah Fauquier
Beginning in December 2018, increased numbers of gray whale (Eschrichtius robustus) strandings were reported along the west coast of Mexico, the United States, and Canada, prompting declaration of a gray whale Unusual Mortality Event (UME) by the United States National Marine Fisheries Service. Although strandings declined in 2020 and 2021 from a peak in 2019, the UME is still ongoing as of fall 2023. Between 17 December 2018 and 31 December 2021, 503 animals stranded along the west coast of North America, with 226 strandings in Mexico, 71 in California, 12 in Oregon, 56 in Washington, 21 in British Columbia, and 117 in Alaska...
2024: PloS One
https://read.qxmd.com/read/38536871/species-specific-responses-during-seoul-orthohantavirus-infection-in-human-and-rat-lung-microvascular-endothelial-cells
#30
JOURNAL ARTICLE
Danny Noack, Mirjam C G N van den Hout, Carmen W E Embregts, Wilfred F J van IJcken, Marion P G Koopmans, Barry Rockx
Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome (HFRS) in humans worldwide. In rats, SEOV predominantly exists as a persistent infection in the absence of overt clinical signs. Lack of disease in rats is attributed to downregulation of pro-inflammatory and upregulation of regulatory host responses. As lung microvascular endothelial cells (LMECs) represent a primary target of infection in both human and rats, infections in these cells provide a unique opportunity to study the central role of LMECs in the dichotomy between pathogenicity in both species...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536869/study-protocol-identifying-transcriptional-regulatory-alterations-of-chronic-effects-of-blast-and-disturbed-sleep-in-united-states-veterans
#31
JOURNAL ARTICLE
Molly J Sullan, Kelly A Stearns-Yoder, Zhaoyu Wang, Andrew J Hoisington, Adam D Bramoweth, Walter Carr, Yongchao Ge, Hanga Galfalvy, Fatemah Haghighi, Lisa A Brenner
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries following blast, an exposure that may not result in a definitive physiologic marker (e.g., loss of consciousness). Recent research suggests that exposure to low level blasts and, more specifically repetitive blast exposure (RBE), which may be subconcussive in nature, may also impact long term physiologic and psychological outcomes, though findings have been mixed...
2024: PloS One
https://read.qxmd.com/read/38536860/cost-effectiveness-of-a-pediatric-operating-room-installation-in-sub-saharan-africa
#32
JOURNAL ARTICLE
Ava Yap, Salamatu I Halid, Nancy Ukwu, Ruth Laverde, Paul Park, Greg Klazura, Emma Bryce, Maija Cheung, Elliot Marseille, Doruk Ozgediz, Emmanuel A Ameh
The unmet need for pediatric surgery imposes enormous health and economic consequences globally, predominantly shouldered by Sub-Saharan Africa (SSA) where children comprise almost half of the population. Lack of knowledge about the economic impact of improving pediatric surgical infrastructure in SSA inhibits the informed allocation of limited resources towards the most cost-effective interventions to bolster global surgery for children. We assessed the cost-effectiveness of installing and running two dedicated pediatric operating rooms (ORs) in a hospital in Nigeria with a pre-existing pediatric surgical service by constructing a decision tree model of pediatric surgical delivery at this facility over a year, comparing scenarios before and after the installation of the ORs, which were funded philanthropically...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536849/a-study-on-smart-home-use-intention-of-elderly-consumers-based-on-technology-acceptance-models
#33
JOURNAL ARTICLE
Chengmin Zhou, Yawen Qian, Jake Kaner
PURPOSE: Smart home devices have great potential to improve the quality of life and independence of older people, positively impacting their health, safety, and comfort. However, Chinese research in this field is still in its early stages. Therefore, more comprehensive and in-depth studies are needed to comprehend the various aspects influencing the acceptance and use of smart homes by older users. PATIENTS AND METHODS: This study adopted the Technology Acceptance Model (TAM) and included perceived usefulness, perceived ease of use, usage intention, intergenerational technology support, perceived value, and perceived risk as extension variables to delve deeper into the behavioral intentions of older users in smart home services...
2024: PloS One
https://read.qxmd.com/read/38536819/stem-cell-derived-vessels-on-chip-for-cardiovascular-disease-modeling
#34
JOURNAL ARTICLE
Maren Marder, Caroline Remmert, Julius A Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus, Matthias Meier
The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel-on-chip platform that integrates human pluripotent stem cell-derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single-cell RNA sequencing, proteomics by mass spectrometry, and high-resolution imaging...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536804/prevalence-of-physical-violence-against-people-in-insecure-migration-status-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Alexandria Innes, Sophie Carlisle, Hannah Manzur, Elizabeth Cook, Jessica Corsi, Natalia V Lewis
OBJECTIVES: This study summarised evidence on the prevalence of interpersonal, community and state physical violence against people in insecure migration status. METHODS: We conducted a systematic review and meta-analysis of primary studies that estimated prevalence of physical violence against a population in insecure migration status. We searched Embase, Social Policy and Practice, Political Science Complete, SocINDEX and Web of Science Social Sciences Citation Index for reports published from January 2000 until 31 May 2023...
2024: PloS One
https://read.qxmd.com/read/38536782/a-machine-learning-based-depression-screening-framework-using-temporal-domain-features-of-the-electroencephalography-signals
#36
JOURNAL ARTICLE
Sheharyar Khan, Sanay Muhammad Umar Saeed, Jaroslav Frnda, Aamir Arsalan, Rashid Amin, Rahma Gantassi, Sadam Hussain Noorani
Depression is a serious mental health disorder affecting millions of individuals worldwide. Timely and precise recognition of depression is vital for appropriate mediation and effective treatment. Electroencephalography (EEG) has surfaced as a promising tool for inspecting the neural correlates of depression and therefore, has the potential to contribute to the diagnosis of depression effectively. This study presents an EEG-based mental depressive disorder detection mechanism using a publicly available EEG dataset called Multi-modal Open Dataset for Mental-disorder Analysis (MODMA)...
2024: PloS One
https://read.qxmd.com/read/38536769/reversible-c%C3%A2-n-bond-formation-controls-charge-separation-in-an-aza-diarylethene-photoswitch
#37
JOURNAL ARTICLE
Maximilian Sacherer, Sofia Gracheva, Harald Maid, Christian Placht, Frank Hampel, Henry Dube
Diarylethenes belong to the most eminent photoswitches and have been studied for many decades. They are found in virtually every field of application and have become highly valuable molecular tools for instilling light-responsiveness into materials, catalysts, biological systems, or pharmacology. In this work, we present a novel and distinct type of pyrimidine-based aza-diarylethene, which undergoes a highly unusual zwitterion-forming photoreaction. During this fully reversible process, a CN double bond is established under concomitant aromatization and thiophene-ring opening...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38536768/wettability-and-bactericidal-properties-of-bioinspired-zno-nanopillar-surfaces
#38
JOURNAL ARTICLE
Jitao Zhang, Georgia Williams, Thanaphun Jitniyom, Navdeep Sangeet Singh, Alexander Saal, Lily Riordan, Madeline Berrow, James Churm, Manuel Banzhaf, Felicity de Cogan, Nan Gao
Nanomaterials of zinc oxide (ZnO) exhibit antibacterial activities under ambient illumination that result in cell membrane permeability and disorganization, representing an important opportunity for health-related applications. However, the development of antibiofouling surfaces incorporating ZnO nanomaterials has remained limited. In this work, we fabricate superhydrophobic surfaces based on ZnO nanopillars. Water droplets on these superhydrophobic surfaces exhibit small contact angle hysteresis (within 2-3°) and a minimal tilting angle of 1°...
March 27, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38536762/the-impact-of-musculoskeletal-ill-health-on-quality-of-life-and-function-after-critical-care-a-multicentre-prospective-cohort-study
#39
JOURNAL ARTICLE
O D Gustafson, E B King, M M Schlussel, A Arnold, C Wade, P S Nicol, M J Rowland, H Dawes, M A Williams
Physical disability is a common component of post-intensive care syndrome, but the importance of musculoskeletal health in this population is currently unknown. We aimed to determine the musculoskeletal health state of intensive care unit survivors and assess its relationship with health-related quality of life; employment; and psychological and physical function. We conducted a multicentre prospective cohort study of adults admitted to intensive care for > 48 h without musculoskeletal trauma or neurological insult...
March 27, 2024: Anaesthesia
https://read.qxmd.com/read/38536760/nonpharmacologic-rate-control-of-postoperative-atrial-fibrillation-in-the-canine-sterile-pericarditis-model
#40
JOURNAL ARTICLE
Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan
INTRODUCTION: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model...
March 27, 2024: Journal of Cardiovascular Electrophysiology
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