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https://www.readbyqxmd.com/read/29145698/illicit-drug-use-illicit-drug-use-disorders-and-drug-overdose-deaths-in-metropolitan-and-nonmetropolitan-areas-united-states
#1
EDITORIAL
Karin A Mack, Christopher M Jones, Michael F Ballesteros
PROBLEM/CONDITION: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies. REPORTING PERIOD: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015...
December 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29145667/planarians-customize-their-stem-cell-responses-following-genotoxic-stress-as-a-function-of-exposure-time-and-regenerative-state
#2
An-Sofie Stevens, Annelies Wouters, Jan-Pieter Ploem, Nicky Pirotte, Andromeda Van Roten, Maxime Willems, Niels Hellings, Carmen Franken, Gudrun Koppen, Tom Artois, Michelle Plusquin, Karen Smeets
Aiming to in vivo characterise the responses of pluripotent stem cells and regenerative tissues to carcinogenic stress, we employed the highly regenerative organism Schmidtea mediterranea. Its broad regenerative capacities are attributable to a large pool of pluripotent stem cells, which are considered key players in the lower vulnerability towards chemically-induced carcinogenesis observed in regenerative organisms. S. mediterranea is, therefore, an ideal model to study pluripotent stem cell responses with stem cells residing in their natural environment...
November 14, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29145647/trends-and-correlates-of-waterpipe-use-in-the-european-union-analysis-of-selected-eurobarometer-surveys-2009-2017
#3
Filippos T Filippidis, Mohammed Jawad, Constantine I Vardavas
Introduction: To assess the trends and correlates of waterpipe use between 2009 and 2017 in the 28 European Union (EU) member states. Methods: We analysed data from wave 72.3 (2009, n=27,788); wave 77.1 (2012, n=26,751); wave 82.4 (2014, n=27,801); and wave 87.1 (2017, n=27,901) of the Eurobarometer survey. Representative samples of EU residents aged ≥15 years were asked to report ever use of waterpipe. Regular waterpipe use, i.e. at least once a month was also assessed in 2017...
November 14, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29145633/the-initiation-propagation-and-dynamics-of-crispr-spycas9-r-loop-complex
#4
Yan Zeng, Yang Cui, Yong Zhang, Yanruo Zhang, Meng Liang, Hui Chen, Jie Lan, Guangtao Song, Jizhong Lou
CRISPR-Cas9 system has been widely used for efficient genome editing. Although the structures of Cas9 protein in complex with single-guided RNA (sgRNA) and target DNA have been resolved, the molecular details about the formation of Cas9 endonuclease R-loop structure remain elusive. Here we examine the DNA cleavage activities of Streptococcus pyogenes Cas9 (SpyCas9) and its mutants using various target sequences and study the conformational dynamics of R-loop structure during target binding using single-molecule fluorescence energy transfer (smFRET) technique...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145617/radiological-impact-of-some-common-foods-of-southern-part-of-west-bengal-india
#5
Biswajit Das, Argha Deb, Saheli Chowdhury
An appreciable portion of human exposure to natural radioactivity comes from food and drinking water. Gross alpha radioactivity has been measured in thirty one food items consumed almost every day by the people of southern part of West Bengal, India, by using the solid state nuclear track detector LR-115. The annual effective doses due to intake of alpha-emitting radionuclides through these food items have also been estimated, and the total average annual dose received by an adultthrough ingestion of these foodstuffs calculated, considering the food habit of the people of the region...
November 14, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29145606/-prokaryotic-pathway-is-not-prokaryotic-non-cyanobacterial-origin-of-the-chloroplast-lipid-biosynthetic-pathway-revealed-by-comprehensive-phylogenomic-analysis
#6
Naoki Sato, Koichiro Awai
Lipid biosynthesis within the chloroplast, or more generally plastids, was conventionally called "prokaryotic pathway", which produces glycerolipids bearing C18 acids at the sn-1 position and C16 acids at the sn-2 position, as in cyanobacteria such as Anabaena and Synechocystis. This positional specificity is determined during the synthesis of phosphatidate, which is a precursor to diacylglycerol, the acceptor of galactose for the synthesis of galactolipids. The first acylation at sn-1 is catalyzed by glycerol-3-phosphate acyltransferase (GPAT or GPT), whereas the second acylation at sn-2 is performed by lysophosphatidate acyltransferase (LPAAT, AGPAT or PlsC)...
November 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29145597/laboratory-testing-of-a-cohort-of-commercially-insured-users-of-hiv-preexposure-prophylaxis-in-the-united-states-2011-2015
#7
Ya-Lin A Huang, Guoyu Tao, Taraz Samandari, Karen W Hoover
To ensure the health and safety of persons taking antiretroviral medication for HIV preexposure prophylaxis (PrEP), CDC guidelines recommend initial and follow-up laboratory testing. We assessed the rates of recommended testing using a commercial insurance claims database. Before taking PrEP, 45% of users were tested for HIV, 31% for creatinine, 55% for syphilis, 43% for chlamydia/gonorrhea, and 38% for hepatitis B. By 6 months after PrEP initiation, 38% were tested for HIV, 37% for creatinine, 49% for syphilis, and 39% for chlamydia/gonorrhea...
November 14, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29145595/synchrony-weather-and-cycles-in-southern-pine-beetle-coleoptera-curculionidae
#8
John D Reeve
Spatial synchrony and cycles are common features of forest insect pests, but are often studied as separate phenomenon. Using time series of timber damage caused by Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae) (southern pine beetle) in 10 states within the southern United States, this study examines synchrony in D. frontalis abundance, the synchronizing effects of temperature extremes, and the evidence for shared cycles among state populations. Cross-correlation and cluster analyses are used to quantify synchrony across a range of geographic distances and to identify groups of states with synchronous dynamics...
November 14, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29145545/treatment-of-alcohol-induced-psychotic-disorder-alcoholic-hallucinosis-a-systematic-review
#9
Barkat Masood, Peter Lepping, Dmitry Romanov, Rob Poole
Aims: To evaluate the effectiveness of evidence based treatments for alcohol-induced psychotic disorder (AIPD) as described by ICD-10 and DSM-5, a condition that is distinct from schizophrenia and has a close relationship with alcohol withdrawal states. Method: Systematic review using PRISMA guidelines. Results: Of 6205 abstracts found, fifteen studies and ten case reports met criteria and were examined. Larger studies examined the use of first-generation antipsychotic drugs, reporting full or partial remission in most patients...
November 14, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29145514/why-patients-with-thbd-c-1611c-a-p-cys537x-nonsense-mutation-have-high-levels-of-soluble-thrombomodulin
#10
Yohann Jourdy, Nathalie Enjolras, Sandra Le Quellec, Jean Claude Bordet, Claude Négrier, Christine Vinciguerra, Yesim Dargaud
BACKGROUND: Recently our group has described a new autosomal dominant bleeding disorder characterized by very high plasma levels of soluble thrombomodulin (TM). The THBD c.1611C>A (p.Cys537X) mutation in heterozygous state was found in the propositus. This mutation leads to the synthesis of a truncated TM which has lost the last three amino-acids of the transmembrane domain and the cytoplasmic tail. OBJECTIVE: We investigated the mechanism responsible for TM shedding in endothelial cells with THBD c...
2017: PloS One
https://www.readbyqxmd.com/read/29145479/new-analytical-methodology-for-analysing-s-iv-species-at-low-ph-solutions-by-one-stage-titration-method-bichromatometry-with-a-clear-colour-change-could-potentially-replace-the-state-of-art-method-iodometry-at-low-ph-analysis-due-higher-accuracy
#11
Annukka Santasalo-Aarnio, Istvan Galfi, Jorma Virtanen, Michael M Gasik
A new, faster and more reliable analytical methodology for S(IV) species analysis at low pH solutions by bichromatometry is proposed. For decades the state of the art methodology has been iodometry that is still well justified method for neutral solutions, thus at low pH media possess various side reactions increasing inaccuracy. In contrast, the new methodology has no side reactions at low pH media, requires only one titration step and provides a clear color change if S(IV) species are present in the solution...
2017: PloS One
https://www.readbyqxmd.com/read/29145462/circulating-soluble-endoglin-modifies-the-inflammatory-response-in-mice
#12
Laura Ruiz-Remolina, Claudia Ollauri-Ibáñez, Lucía Pérez-Roque, Elena Núñez-Gómez, Fernando Pérez-Barriocanal, José Miguel López-Novoa, Miguel Pericacho, Alicia Rodríguez-Barbero
Inflammation is associated with every health condition, and is an important component of many pathologies such as cardiovascular diseases. Circulating levels of soluble endoglin have been shown to be higher in the serum of patients with cardiovascular diseases with a significant inflammatory component. The aim of this study was to evaluate the implication of circulating soluble endoglin in the inflammatory response. For this purpose, a transgenic mouse expressing human soluble endoglin (sEng+) was employed, and three different inflammatory approaches were used to mimic inflammatory conditions in different tissues...
2017: PloS One
https://www.readbyqxmd.com/read/29145458/a-model-guided-symbolic-execution-approach-for-network-protocol-implementations-and-vulnerability-detection
#13
Shameng Wen, Qingkun Meng, Chao Feng, Chaojing Tang
Formal techniques have been devoted to analyzing whether network protocol specifications violate security policies; however, these methods cannot detect vulnerabilities in the implementations of the network protocols themselves. Symbolic execution can be used to analyze the paths of the network protocol implementations, but for stateful network protocols, it is difficult to reach the deep states of the protocol. This paper proposes a novel model-guided approach to detect vulnerabilities in network protocol implementations...
2017: PloS One
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#14
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/29145408/effect-of-pulse-pressure-on-borehole-stability-during-shear-swirling-flow-vibration-cementing
#15
Zhihua Cui, Chi Ai, Lei Lv, Fangxian Yin
The shear swirling flow vibration cementing (SSFVC) technique rotates the downhole eccentric cascade by circulating cementing fluid. It makes the casing eccentrically revolve at high speed around the borehole axis. It produces strong agitation action to the annulus fluid, makes it in the state of shear turbulent flow, and results in the formation of pulse pressure which affects the surrounding rock stress. This study was focused on 1) the calculation of the pulse pressure in an annular turbulent flow field based on the finite volume method, and 2) the analysis of the effect of pulse pressure on borehole stability...
2017: PloS One
https://www.readbyqxmd.com/read/29145405/drivers-of-house-invasion-by-sylvatic-chagas-disease-vectors-in-the-amazon-cerrado-transition-a-multi-year-state-wide-assessment-of-municipality-aggregated-surveillance-data
#16
Raíssa N Brito, David E Gorla, Liléia Diotaiuti, Anália C F Gomes, Rita C M Souza, Fernando Abad-Franch
BACKGROUND: Insecticide spraying efficiently controls house infestation by triatomine bugs, the vectors of Trypanosoma cruzi. The strategy, however, is ineffective against sylvatic triatomines, which can transmit Chagas disease by invading (without colonizing) man-made structures. Despite growing awareness of the relevance of these transmission dynamics, the drivers of house invasion by sylvatic triatomines remain poorly understood. METHODS/FINDINGS: About 12,000 sylvatic triatomines were caught during routine surveillance in houses of Tocantins state, Brazil, in 2005-2013...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29145403/us-gulf-coast-states-the-rise-of-neglected-tropical-diseases-in-flyover-nation
#17
Peter J Hotez, Sheila Jackson Lee
No abstract text is available yet for this article.
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29145389/the-use-of-ambient-humidity-conditions-to-improve-influenza-forecast
#18
Jeffrey Shaman, Sasikiran Kandula, Wan Yang, Alicia Karspeck
Laboratory and epidemiological evidence indicate that ambient humidity modulates the survival and transmission of influenza. Here we explore whether the inclusion of humidity forcing in mathematical models describing influenza transmission improves the accuracy of forecasts generated with those models. We generate retrospective forecasts for 95 cities over 10 seasons in the United States and assess both forecast accuracy and error. Overall, we find that humidity forcing improves forecast performance (at 1-4 lead weeks, 3...
November 16, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29145359/racial-ethnic-health-disparities-among-rural-adults-united-states-2012-2015
#19
Cara V James, Ramal Moonesinghe, Shondelle M Wilson-Frederick, Jeffrey E Hall, Ana Penman-Aguilar, Karen Bouye
PROBLEM/CONDITION: Rural communities often have worse health outcomes, have less access to care, and are less diverse than urban communities. Much of the research on rural health disparities examines disparities between rural and urban communities, with fewer studies on disparities within rural communities. This report provides an overview of racial/ethnic health disparities for selected indicators in rural areas of the United States. REPORTING PERIOD: 2012-2015...
November 17, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29145356/quickstats-percentage-of-adults-aged-20-64-years-whose-blood-cholesterol-was-checked-by-a-health-professional-in-the-past-12-months-%C3%A2-by-race-ethnicity-%C3%A2-national-health-interview-survey-%C3%A2-united-states-2011-and-2016
#20
(no author information available yet)
The percentage of adults aged 20-64 years who had a blood cholesterol check by a health professional in the past 12 months increased from 56.0% in 2011 to 61.7% in 2016. From 2011 to 2016, there was an increase in the percentage of adults with a blood cholesterol check among Hispanic (49.0% to 56.7%), non-Hispanic white (56.8% to 62.5%), non-Hispanic black (60.8% to 65.6%), and non-Hispanic Asian (55.8% to 63.0%) persons. In both years, non-Hispanic black adults were more likely than non-Hispanic white adults to have had a blood cholesterol check, and Hispanic adults were the least likely to have had a blood cholesterol check...
November 17, 2017: MMWR. Morbidity and Mortality Weekly Report
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