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https://www.readbyqxmd.com/read/29684942/reanalysis-of-the-trotter-tibia-quandary-and-its-continued-effect-on-stature-estimation-of-past-conflict-service-members
#1
Jeffrey James Lynch, Carrie Brown, Andrea Palmiotto, Heli Maijanen, Franklin Damann
Forensic casework from past-conflicts relies on the corrected historical Trotter data for stature estimation in Fordisc. For roughly 10 years', stature estimation using this data has produced point estimates for the tibia that are on average 1.25 inches less than the other long bones. This issue was identified after applying the equations derived from Fordisc to the USS Oklahoma commingled assemblage. Reevaluation of Fordisc revealed that a correction factor of 20 mm, instead of 10 mm, was mistakenly applied to the Trotter tibia data...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684939/loose-lipped-mobile-device-intelligent-personal-assistants-a-discussion-of-information-gleaned-from-siri-on-locked-ios-devices
#2
Graeme Horsman
The forensic analysis of mobile handsets is becoming a more prominent factor in many criminal investigations. Despite such devices frequently storing relevant evidential content to support an investigation, accessing this information is becoming an increasingly difficult task due to enhanced effective security features. Where access to a device's resident data is not possible via traditional mobile forensic methods, in some cases it may still be possible to extract user information via queries made to an installed intelligent personal assistant...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684929/-prevalence-of-multidrug-resistant-gram-negative-bacteria
#3
Axel G Hamprecht, Stephan Göttig
The increase of multidrug-resistant Gram-negative bacilli (MRGN) is a great threat for both the health system and patients. Challenges of MRGN for physicians are limited therapeutic options, the need of infection control measures and the danger of outbreaks. In this article, the prevalence of MRGN, risk factors, the background and definitions of multidrug-resistant organisms are presented.
May 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29684916/predictors-of-rapid-cognitive-decline-in-patients-with-mild-to-moderate-alzheimer-disease-a-prospective-cohort-study-with-12-month-follow-up-performed-in-memory-clinics
#4
Achille E Tchalla, Jean-Pierre Clément, Isabelle Saulnier, Betty Beaumatin, Florent Lachal, Caroline Gayot, Anaïs Bosetti, Iléana Desormais, Anaïck Perrochon, Pierre-Marie Preux, Philippe Couratier, Thierry Dantoine
BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. Community-living individuals aged ≥65 years with mild-to-moderate AD were included...
April 23, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29684913/does-trade-liberalization-reduce-child-mortality-in-low-and-middle-income-countries-a-synthetic-control-analysis-of-36-policy-experiments-1963-2005
#5
Pepita Barlow
Scholars have long argued that trade liberalization leads to lower rates of child mortality in developing countries. Yet current scholarship precludes definitive conclusions about the magnitude and direction of this relationship. Here I analyze the impact of trade liberalization on child mortality in 36 low- and middle-income countries, 1963-2005, using the synthetic control method. I test the hypothesis that trade liberalization leads to lower rates of child mortality, examine whether this association varies between countries and over time, and explore the potentially modifying role of democratic politics, historical context, and geographic location on the magnitude and direction of this relationship...
April 6, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684912/cementum-regeneration-using-stem-cells-in-the-dog-model-a-systematic-review
#6
REVIEW
Jacqueline Crossman, Maryam Elyasi, Tarek El-Bialy, Carlos Flores Mir
OBJECTIVE: Restoring lost tissues of the periodontium, such as cementum, is essential in reducing the risk of tooth loss due to periodontitis and/or severe root resorption. Stem cell therapy is a regenerative strategy in cementum regeneration. This systematic review aimed to analyze the effect of various stem cells and their transplantation method on cementum regeneration in the dog model. METHODS: Electronic databases were searched, in addition to performing hand searches and a gray literature search...
April 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29684900/generation-of-the-human-induced-pluripotent-stem-cell-hipsc-line-psmi003-a-from-a-patient-affected-by-an-autosomal-recessive-form-of-long-qt-syndrome-type-1
#7
Manuela Mura, Monia Ginevrino, Rita Zappatore, Federica Pisano, Marina Boni, Silvia Castelletti, Lia Crotti, Enza Maria Valente, Peter J Schwartz, Massimiliano Gnecchi
We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a 51years old female patient homozygous for the mutation c.535 G>A p.G179S on the KCNQ1 gene, causing a severe form of autosomal recessive Long QT Syndrome type 1 (AR-LQT1), not associated with deafness. The hiPSCs, generated using four retroviruses each encoding for a reprogramming factor OCT4, SOX2, KLF4, cMYC, are pluripotent and can differentiate into spontaneously beating cardiomyocytes (hiPSC-CMs).
April 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29684891/considering-high-alcohol-and-violence-neighborhood-context-using-daily-diaries-and-gps-a-pilot-study-among-people-living-with-hiv
#8
Katherine P Theall, Erica Felker-Kantor, Maeve Wallace, Xiao Zhang, Christopher N Morrison, Douglas J Wiebe
Our understanding of how community-level context impacts care of persons living with HIV (PLWH), including antiretroviral therapy (ART) adherence and retention in care, is limited. The objective of this study was to characterize the activity spaces of PLWH from an urban area in Southeastern U.S., where the epidemic is among the nation's highest, and to examine how such activity spaces are associated with daily mood and health behaviors. In this small, pilot study, 11 participants were tracked with a global positioning system (GPS)-enabled application on their smartphones for 2 weeks...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29684876/investigating-the-association-between-urinary-levels-of-acrylonitrile-metabolite-n-acetyl-s-2-cyanoethyl-l-cysteine-and-the-oxidative-stress-product-8-hydroxydeoxyguanosine-in-adolescents-and-young-adults
#9
Chien-Yu Lin, Hui-Ling Lee, Fung-Chang Sung, Ta-Chen Su
Acrylonitrile is a colorless volatile liquid mostly present in tobacco smoke. Acrylonitrile exposure has shown to increase oxidative stress in animal studies; however, there was no previous research in human epidemiology. In this study, 853 subjects were recruited from a cohort of Taiwanese adolescents and young adults to investigate the association between urinary concentrations of the acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine (CEMA), the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) and cardiovascular disease (CVD) risk factors...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684869/resuscitation-of-functional-bacterial-community-for-enhancing-biodegradation-of-phenol-under-high-salinity-conditions-based-on-rpf
#10
Xiaomei Su, Yuyang Wang, Binbing Xue, Yunge Zhang, Rongwu Mei, Yu Zhang, Muhammad Zaffar Hashmi, Hongjun Lin, Jianrong Chen, Faqian Sun
This study assumed that key degraders of functional bacterial community were prone to enter into the viable but non-culturable (VBNC) state under high saline phenolic conditions, and resuscitation-promoting factor (Rpf) could strengthen these degraders for better performances. Based on these assumptions, Rpf was used to enhance salt-tolerant phenol-degrading capability of functional populations in activated sludge. Results suggested that Rpf accelerated the start-up process during sludge domestication, and significantly enhanced salt-tolerant phenol-degrading capability...
April 13, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29684864/temperamental-factors-in-remitted-depression-the-role-of-effortful-control-and-attentional-mechanisms
#11
Igor Marchetti, Jason Shumake, Ivan Grahek, Ernst H W Koster
BACKGROUND: Temperamental effortful control and attentional networks are increasingly viewed as important underlying processes in depression and anxiety. However, it is still unknown whether these factors facilitate depressive and anxiety symptoms in the general population and, more specifically, in remitted depressed individuals. METHODS: We investigated to what extent effortful control and attentional networks (i.e., Attention Network Task) explain concurrent depressive and anxious symptoms in healthy individuals (n = 270) and remitted depressed individuals (n = 90)...
April 13, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684863/psychological-and-genetic-risk-factors-associated-with-suicidal-behavior-in-korean-patients-with-mood-disorders
#12
Hee-Yeon Choi, Ga Eun Kim, Kyoung Ae Kong, Yu Jin Lee, Weon-Jeong Lim, So-Hyun Park, Su Hee Ha, Soo In Kim
INTRODUCTION: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. METHODS: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404)...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29684862/antioxidant-effects-of-lycium-barbarum-polysaccharides-on-photoreceptor-degeneration-in-the-light-exposed-mouse-retina
#13
Liujiu Tang, Shuyin Bao, Yu Du, Zengyan Jiang, A O Wuliji, Xiang Ren, Chenghong Zhang, Haiying Chu, Li Kong, Haiying Ma
We assessed the neuroprotective effects of Lycium barbarum Polysaccharides (LBP) on photoreceptor degeneration and the mechanisms involved in oxidative stress in light-exposed mouse retinas. Mice were given a gavage of LBP (150 mg/kg or 300 mg/kg) or phosphate buffered saline (PBS) for 7 days before exposure to light (5000 lx for 24 h). We found that LBP significantly improved the electroretinography (ERG) amplitudes of the a- and b-waves that had been attenuated by light exposure. In addition, changes caused by light exposure including photoreceptor cell loss, nuclear condensation, an increased number of mitochondria vacuoles, outer membrane disc swelling and cristae fractures were distinctly ameliorated by LBP...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684860/polyphenol-rich-extract-of-ocimum-gratissimum-leaves-ameliorates-colitis-via-attenuating-colonic-mucosa-injury-and-regulating-pro-inflammatory-cytokines-production-and-oxidative-stress
#14
Quadri K Alabi, Rufus O Akomolafe, Joseph G Omole, Modinat A Adefisayo, Olaofe L Ogundipe, Ayodeji Aturamu, Joseph O Sanya
Colitis is a chronic inflammation and ulcer on the inner lining of the large intestine. For many centuries Ocimum gratissimum (OG) leaves have been used in folk medicine in Nigeria to treat inflammatory bowel diseases, however, to date, the anti-colitis effects of OG have not been scientifically proven. In this study we investigated the effects of polyphenol rich extract of Ocimum gratissimum (PREOG) leaf on colonic mucosa injury in colitis, its mechanisms, initial administration time and dosage. Dextran sodium sulfate (DSS)-induced rat colitis models was used...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684858/a-novel-triazine-ring-compound-md568-exerts-in-vivo-and-in-vitro-effects-on-lipid-metabolism
#15
Dan Jia, Ziwen Li, Ying Gao, Yifan Feng, Weimin Li
In this study, we investigated the toxicity and biological activity of a novel triazine ring compound named magnolol derivative 568 (MD568). The LD50 of MD568 was determined in Sprague-Dawley (SD) rats by intraperitoneal injection. Treatment of high fat diet-induced obese rats with MD568 demonstrated that MD568 displayed significant anti-obesity effects. MD568 markedly reduced body weight, blood lipid contents, white adipose tissue (WAT) and liver mass in obese rats. In addition, MD568 modulated lesions in WAT through regulating PPAR-Ɣ, C/EBP-a, SREBP-1c and FABP-4 proteins in the liver through regulating PPAR-α, SREBP-1c and FABP-4...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684855/post-transcription-mediated-snail-stabilization-is-involved-in-radiation-exposure-induced-invasion-and-migration-of-hepatocarcinoma-cells
#16
Liyang Dong, Xuebang Zhang, Wei Xiang, Junwei Ni, Weizhong Zhou, Haiyan Li
Increasing evidences suggested that radiotherapy can paradoxically promote tumor invasion and metastatic processes, while its detailed mechanism is not well illustrated. Our present study found that radiation can promote the migration and invasion of hepatocellular carcinoma (HCC) cells via induction of epithelial mesenchymal transition (EMT), which was evidenced by the results that radiation induced up regulation of vimentin while down regulation of E-Cadherin. As to the EMT-related transcription factors, radiation increased the expression of Snail, while not Slug, ZEB1 or TWIST...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684854/the-role-of-her2-nrf2-axis-in-induction-of-oxaliplatin-resistance-in-colon-cancer-cells
#17
Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Kobra Velaie, Mohammad Reza Sadeghi, Nasser Samadi
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in promoting chemoresistance by regulation of antioxidants and detoxification enzymes. Her2 is a member of tyrosine kinase receptor family with a key function in resistance of cancer cells to chemotherapeutics. The aim of this study was to investigate the possible cross talk between Nrf2 and Her2 mediated signaling pathways in development of oxaliplatin resistance in colon cancer cells. We first generated oxaliplatin-resistant LS174T and SW480 colon cancer cells with different Her2 expression levels by employing IC50 concentrations followed by a resting period...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684852/polysaccharide-from-rhizopus-nigricans-inhibits-the-invasion-and-metastasis-of-colorectal-cancer
#18
Zhidan Yu, Qingjie Sun, Jing Liu, Xiujuan Zhang, Ge Song, Guodong Wang, Pengying Zhang, Kaoshan Chen
Polysaccharide (EPS1-1) extracted from fermentation liquor of Rhizopus nigricans possesses antitumor and immune-enhancing activities. The study was the first to investigate the anti-metastasis effects of EPS1-1 in vitro and in vivo. Results suggested that EPS1-1 dose-dependently suppressed the migration, invasion and adhesion abilities of CT26 cells. Furthermore, EPS1-1 dramatically inhibited the enzyme activity and expression levels of matrix metalloproteinases (MMPs) in CT26 cells, as well as the tube formation of HUVECs...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684848/protective-effects-of-ifn-%C3%AE-on-the-kidney-of-type-2-diabetic-kkay-mice
#19
Juan Du, Wenpeng Dong, Huifeng Li, Bo Li, Xiaodan Liu, Qinghui Kong, Wei Sun, Tingli Sun, Peilong Ma, Yan Cui, Ping Kang
BACKGROUND: Development of novel therapeutic strategies that specifically target diabetic kidney disease (DKD) is urgently needed. METHODS: Male KKAy mice were divided randomly into three equal groups - KK, KI, and KF; Male C57BL/6 mice were the control group. All KKAy mice were fed a high-fat diet. From the 16th week, the KI group was given IFN-γ, and the KF group was assigned to be treated with fludarabine. C57BL/6 mice were always fed a normal mouse diet. Every 4 weeks, body weight, random blood sugar, urine albumin and urea of all mice were measured...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29684844/consumer-acceptance-of-cultured-meat-a-systematic-review
#20
REVIEW
Christopher Bryant, Julie Barnett
Cultured meat grown in-vitro from animal cells is being developed as a way of addressing many of the ethical and environmental concerns associated with conventional meat production. As commercialisation of this technology appears increasingly feasible, there is growing interest in the research on consumer acceptance of cultured meat. We present a systematic review of the peer-reviewed literature, and synthesize and analyse the findings of 14 empirical studies. We highlight demographic variations in consumer acceptance, factors influencing acceptance, common consumer objections, perceived benefits, and areas of uncertainty...
April 12, 2018: Meat Science
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