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https://www.readbyqxmd.com/read/28922901/localization-of-an-aldo-keto-reductase-akr2e4-in-the-silkworm-bombyx-mori-lepidoptera-bombycidae
#1
K Yamamoto, Y Ozakiya, T Uno
The aldo-keto reductase AKR2E4 reduces 3-dehydroecdysone to ecdysone in the silkworm Bombyx mori L. In this study, a quantitative polymerase chain reaction analysis revealed that the level of AKR2E4 mRNA was higher in the testes than in other tissues, and a western immunoblot analysis revealed that the AKR2E4 content in the testes was stage-specific from the fifth larval instar to the pupal stage. Immunohistochemical analysis showed that the AKR2E4 protein was present in cyst cells associated with sperm cells and spermatocytes...
September 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28922863/does-intensification-of-chemotherapy-in-anaplastic-oligodendrogliomas-still-have-a-role
#2
Riccardo Soffietti
No abstract text is available yet for this article.
October 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28922860/structural-plasticity-of-synaptopodin-in-the-axon-initial-segment-during-visual-cortex-development
#3
Annabelle Schlüter, Domenico Del Turco, Thomas Deller, Annika Gutzmann, Christian Schultz, Maren Engelhardt
The axon initial segment (AIS) is essential for action potential generation. Recently, the AIS was identified as a site of neuronal plasticity. A subpopulation of AIS in cortical principal neurons contains stacks of endoplasmic reticulum (ER) forming the cisternal organelle (CO). The function of this organelle is poorly understood, but roles in local Ca2+-trafficking and AIS plasticity are discussed. To investigate whether the presence and/or the size of COs are linked to the development and maturation of AIS of cortical neurons, we analyzed the relationship between COs and the AIS during visual cortex development under control and visual deprivation conditions...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922855/a%C3%A2-complex-code-of-extrinsic-influences-on-cortical-progenitor-cells-of-higher-mammals
#4
Isabel Reillo, Camino de Juan Romero, Adrián Cárdenas, Francisco Clascá, Maria Ángeles Martínez-Martinez, Víctor Borrell
Development of the cerebral cortex depends critically on the regulation of progenitor cell proliferation and fate. Cortical progenitor cells are remarkably diverse with regard to their morphology as well as laminar and areal position. Extrinsic factors, such as thalamic axons, have been proposed to play key roles in progenitor cell regulation, but the diversity, extent and timing of interactions between extrinsic elements and each class of cortical progenitor cell in higher mammals remain undefined. Here we use the ferret to demonstrate the existence of a complex set of extrinsic elements that may interact, alone or in combination, with subpopulations of progenitor cells, defining a code of extrinsic influences...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922851/%C3%AE-endosulfine-arpp-19e-expression-in-a-rat-model-of-stroke
#5
Rupal I Mehta, Natalia Tsymbalyuk, Svetlana Ivanova, Jesse A Stokum, Kyoon Woo, Volodymyr Gerzanich, J Marc Simard
In nutrient restricted environments, the yeast endosulfines Igo1/2 are activated via TORC1 inhibition and function critically to initiate and coordinate the cellular stress response that promotes survival. We examined expression of αEnsa, the mammalian homolog of yeast endosulfines, in rat stroke. Prominent neuronal upregulation of αEnsa was identified in 3 patterns within the ischemic gradient: (1) neurons in GFAP-/HSF1+ cortex showed upregulation and near-complete nuclear translocation of αEnsa protein within hours of ischemic onset; (2) neurons in GFAP+/HSF1+ cortex showed upregulation in cytoplasm and nuclei that persisted for days; (3) neurons in GFAP+/HSF1- cortex showed delayed cytosolic-only upregulation that persisted for days...
October 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28922842/on-faculty-development-of-stem-inclusive-teaching-practices
#6
Bryan M Dewsbury
Faculty development of inclusive teaching practices has become more common in response to significant differences in STEM student retention between underrepresented minorities in the USA and students from other ethnic groups. Approaches to solve this have shifted from focusing on student deficits to changing campus culture, including the mindsets of instructors who teach STEM courses. In this article, I argue that based on the literature informing the conceptual frameworks used for faculty development in inclusive teaching, faculty developers should reframe the message of their workshops to focus participants more on the scope of the journey, and shift the direction of overall efforts some to redevelop pedagogical training at the graduate and postdoc levels...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28922834/how-we-transmit-memories-to-other-brains-constructing-shared-neural-representations-via-communication
#7
A Zadbood, J Chen, Y C Leong, K A Norman, U Hasson
Humans are able to mentally construct an episode when listening to another person's recollection, even though they themselves did not experience the events. However, it is unknown how strongly the neural patterns elicited by mental construction resemble those found in the brain of the individual who experienced the original events. Using fMRI and a verbal communication task, we traced how neural patterns associated with viewing specific scenes in a movie are encoded, recalled, and then transferred to a group of naïve listeners...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922831/the-transcription-factors-coup-tfi-and-coup-tfii-have-distinct-roles-in-arealisation-and-gabaergic-interneuron-specification-in-the-early-human-fetal-telencephalon
#8
Ayman Alzu'bi, Susan J Lindsay, Lauren F Harkin, Jack McIntyre, Steven N Lisgo, Gavin J Clowry
In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal sensory neocortex and dorsal hippocampus whereas COUPTFI/COUPTFII co-expression defined ventral temporal cortex and ventral hippocampus...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922825/catholic-understandings-of-female-sexuality-in-1960s-britain
#9
David Geiringer
Recent interpretations of religious change in modern Britain have stressed the importance of a sudden and abrupt 'sexual revolution' during the 1960s. The role the Churches played in bringing about their own demise remains a point of debate, particularly in the case of the Catholic Church. This article attempts to move beyond existing historical disputes over a 'religious crisis' and whether it was rooted in 'internal' causes (problems within the Church) or 'external', secular developments. It explores the way sexual knowledge was discussed and disseminated by Catholic authorities during this decade of perceived cultural transition, drawing on the previously unpublished papers of the Papal Commission for Birth Control 1963-5 and the training manuals of the Catholic Marriage Advisory Council (CMAC)...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922824/in-quest-of-the-antique-the-bazaar-exchange-and-mart-and-the-democratization-of-collecting-1926-42
#10
Heidi Egginton
The popularization of antique collecting is typically located in the second half of the twentieth century, with the rise of 'retrochic' and the emergence of new markets and online trading websites for anonymously exchanging second-hand goods. Close study of the printed literature connected with the inter-war second-hand trade, however, challenges conventional chronologies in the history of consumer culture, and can provide a new perspective on the role of collecting in British social and cultural life. This article examines the period, after the late 1920s, during which The Bazaar, Exchange and Mart reinvented itself as a forum for antique and decorative art enthusiasts...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922820/justifying-british-advertising-in-war-and-austerity-1939-51
#11
Philippa Haughton
Drawing together institutional papers, the trade- and national-press, and Mass-Observation documents, this article examines the changing ways that the Advertising Association justified commercial advertising from 1939 to 1951. It argues that the ability to repeatedly re-conceptualize the social and economic purposes of advertising was central to the industry's survival and revival during the years of war and austerity. This matters because the survival and revival of commercial advertising helps to explain the composition of the post-war mixed economy and the emergence of a consumer culture that became the 'golden age' of capitalism...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922815/duncan-tanner-essay-prize-2016-historical-pageants-citizenship-and-the-performance-of-women-s-history-before-second-wave-feminism
#12
Zoë Thomas
This article argues that the early twentieth-century craze for historical pageants provided an opportunity for women's groups to bring a nascent, accessible form of women's history into the lives of local communities across Britain. Mainstream historical pageants were organized across the country, depicting selected episodes from the past usually relating to the local area. However, more than 200 inter-war pageants staged by women's organizations, church groups, and a number of university colleges have not yet been studied...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922794/genome-wide-variation-patterns-uncover-the-origin-and-selection-in-cultivated-ginseng-panax-ginseng-meyer
#13
Ming-Rui Li, Feng-Xue Shi, Ya-Ling Li, Peng Jiang, Lili Jiao, Bao Liu, Lin-Feng Li
Chinese ginseng (Panax ginseng Meyer) is a medicinally important herb and plays crucial roles in traditional Chinese medicine. Pharmacological analyses identified diverse bioactive components from Chinese ginseng. However, basic biological attributes including domestication and selection of the ginseng plant remain under-investigated. Here, we presented a genome-wide view of the domestication and selection of cultivated ginseng based on the whole genome data. A total of 8,660 protein-coding genes were selected for genome-wide scanning of the 30 wild and cultivated ginseng accessions...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28922793/diurnal-cycling-transcription-factors-of-pineapple-revealed-by-genome-wide-annotation-and-global-transcriptomic-analysis
#14
Anupma Sharma, Ching Man Wai, Ray Ming, Qingyi Yu
Circadian clock provides fitness advantage by coordinating internal metabolic and physiological processes to external cyclic environments. Core clock components exhibit daily rhythmic changes in gene expression, and the majority of them are transcription factors (TFs) and transcription coregulators (TCs). We annotated 1,398 TFs from 67 TF families and 80 TCs from 20 TC families in pineapple, and analyzed their tissue-specific and diurnal expression patterns. Approximately 42% of TFs and 45% of TCs displayed diel rhythmic expression, including 177 TF/TCs cycling only in the nonphotosynthetic leaf tissue, 247 cycling only in the photosynthetic leaf tissue, and 201 cycling in both...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28922791/targeting-hypoxia-to-improve-non-small-cell-lung-cancer-outcome
#15
Ahmed Salem, Marie-Claude Asselin, Bart Reymen, Alan Jackson, Philippe Lambin, Catharine M L West, James P B O'Connor, Corinne Faivre-Finn
Oxygen deprivation (hypoxia) in non-small cell lung cancer (NSCLC) is an important factor in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target, particularly in the context of radiotherapy, which is delivered to more than half of NSCLC patients. However, NSCLC hypoxia-targeted therapy trials have not yet translated into patient benefit. Recently, early termination of promising evofosfamide and tarloxotinib bromide studies due to futility highlighted the need for a paradigm shift in our approach to avoid disappointments in future trials...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922779/targeting-the-myofibroblastic-cancer-associated-fibroblast-phenotype-through-inhibition-of-nox4
#16
Christopher J Hanley, Massimiliano Mellone, Kirsty Ford, Steve M Thirdborough, Toby Mellows, Steven J Frampton, David M Smith, Elena Harden, Cedric Szyndralewiez, Marc Bullock, Fergus Noble, Karwan A Moutasim, Emma V King, Pandurangan Vijayanand, Alex H Mirnezami, Timothy J Underwood, Christian H Ottensmeier, Gareth J Thomas
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential therapeutic targets. However, effective methods to manipulate these cells clinically have yet to be developed. Methods: CAF accumulation and prognostic significance in head and neck cancer (oral, n = 260; oropharyngeal, n = 271), and colorectal cancer (n = 56) was analyzed using immunohistochemistry...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922771/a-specific-role-of-iron-in-promoting-meristematic-cell-division-during-adventitious-root-formation
#17
Alexander Hilo, Fahimeh Shahinnia, Uwe Druege, Philipp Franken, Michael Melzer, Twan Rutten, Nicolaus von Wirén, Mohammad-Reza Hajirezaei
Adventitious root (AR) formation is characterized by a sequence of physiological and morphological processes and determined by external factors, including mineral nutrition, the impacts of which remain largely elusive. Morphological and anatomical evaluation of the effects of mineral elements on AR formation in leafy cuttings of Petunia hybrida revealed a striking stimulation by iron (Fe) and a promotive action of ammonium (NH4+). The optimal application period for these nutrients corresponded to early division of meristematic cells in the rooting zone and coincided with increased transcript levels of mitotic cyclins...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922767/photosynthetic-and-metabolic-acclimation-to-repeated-drought-events-play-key-roles-in-drought-tolerance-in-coffee
#18
Paulo E Menezes-Silva, Lilian M V P Sanglard, Rodrigo T Ávila, Leandro E Morais, Samuel C V Martins, Priscilla Nobres, Camila M Patreze, Marcio A Ferreira, Wagner L Araújo, Alisdair R Fernie, Fábio M DaMatta
Over the last decades, most information on the mechanisms underlying tolerance to drought has been gained by considering this stress as a single event that happens just once in the life of a plant, in contrast to what occurs under natural conditions where recurrent drought episodes are the rule. Here we explored mechanisms of drought tolerance in coffee (Coffea canephora) plants from a broader perspective, integrating key aspects of plant physiology and biochemistry. We show that plants exposed to multiple drought events displayed higher photosynthetic rates, which were largely accounted for by biochemical rather than diffusive or hydraulic factors, than those submitted to drought for the first time...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922766/altered-accumulation-of-osa-mir171b-contributes-to-rice-stripe-virus-infection-by-regulating-disease-symptoms
#19
Aizi Tong, Quan Yuan, Shu Wang, Jiejun Peng, Yuwen Lu, Hongying Zheng, Lin Lin, Hairu Chen, Yifu Gong, Jianping Chen, Fei Yan
Viral infection affects the pattern of plant miRNA expression. It has been presumed that reduction of miR171 and several other miRNAs influences viral symptoms in plants. We here experimentally demonstrate the association of osa-miR171b with rice stripe virus (RSV) symptoms in rice. Inhibition of osa-miR171b caused stunting with reduced chlorophyll content in leaves similar to viral symptoms. Overexpression of osa-miR171b by an artificial miRNA extended vegetative growth and enhanced chlorophyll accumulation in leaves...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922765/snrk1-phosphorylation-of-fusca3-positively-regulates-embryogenesis-seed-yield-and-plant-growth-at-high-temperature-in-arabidopsis
#20
Aaron Chan, Carina Carianopol, Allen Yi-Lun Tsai, Kresanth Varathanajah, Rex Shun Chiu, Sonia Gazzarrini
The transcription factor FUSCA3 (FUS3) acts as a major regulator of seed maturation in Arabidopsis. FUS3 is phosphorylated by the SnRK1 catalytic subunit AKIN10/SnRK1α1, which belongs to a conserved eukaryotic kinase complex involved in energy homeostasis. Here we show that AKIN10 and FUS3 share overlapping expression patterns during embryogenesis, and that FUS3 is phosphorylated by AKIN10 in embryo cell extracts. To understand the role of FUS3 phosphorylation, we generated fus3-3 plants carrying FUS3 phosphorylation-null (FUS3S>A) and phosphorylation-mimic (FUS3S>D) variants...
July 10, 2017: Journal of Experimental Botany
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