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Suture mechanical cancer

Miku Kuritani, Nobuhiro Sakai, Akiko Karakawa, Motoki Isawa, Masahiro Chatani, Takako Negishi-Koga, Takahiro Funatsu, Masamichi Takami
Denosumab is an anti-bone resorptive drug consisting of complete human monoclonal antibodies that targets receptor activator of nuclear factor κB ligand (RANKL), which is responsible for osteoclast formation. The drug has been adapted for bone diseases, such as osteoporosis and bone metastasis related to cancer, but is not used for alveolar bone destruction related to periodontitis. In the present study, we aimed to clarify whether denosumab prevents bone destruction associated with lipopolysaccharide (LPS)-induced calvaria inflammation and experimental periodontitis in model mice...
2018: Biological & Pharmaceutical Bulletin
Ayman Shafei, Maggie M Ramzy, Abdelhares I Hegazy, Ahmed K Husseny, Usama G El-Hadary, Mazen M Taha, Ali A Mosa
The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways...
March 20, 2018: Gene
Qingqing Sang, Heyu Li, Gareth Williams, Huanling Wu, Li-Min Zhu
Dual-drug-loaded pH-responsive fiber scaffolds were successfully prepared by coaxial electrospinning. These were designed with the aim of being sutured into the resection site after tumor removal, to aid recovery and prevent cancer recurrence. The shell was made up of a mixture of gelatin and sodium bicarbonate (added to provide pH-sensitivity), and was loaded with the anti-inflammatory drug ciprofloxacin; the core comprised poly(lactide-co-ε-caprolactone) with the chemotherapeutic doxorubicin hydrochloride...
March 2018: Journal of Biomaterials Applications
Francesco Feroci, Iacopo Giani, Maddalena Baraghini, Luca Romoli, Tiku Zalla, Roberto Quattromani, Stefano Cantafio, Marco Scatizzi
Our aim was to establish the safety and efficacy of barbed suture for enterotomy closure after laparoscopic right colectomy with intracorporeal anastomosis. This study included 47 patients who underwent laparoscopic right hemicolectomy with intracorporeal mechanical anastomosis and barbed suture enterotomy closure (barbed suture closure-BSC) for adenocarcinoma (with the exception of T4 lesions and metastasis), compared with 47 matched patients who underwent laparoscopic right hemicolectomy with intracorporeal mechanical anastomosis and conventional suture enterotomy closure (conventional suture closure-CSC) during the same period...
December 1, 2017: Updates in Surgery
Kazuhito Sasaki, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Koji Murono, Toshiaki Watanabe
BACKGROUND/AIMS: Anastomotic leakage remains the most serious complications of colorectal surgery. To prevent colorectal anastomotic leakage (CAL), an air leak test (ALT) with intraoperative colonoscopy (IOCS) is performed to detect mechanically insufficient colorectal anastomoses. The approaches to an intraoperative anastomotic air leak (IOAL) have not been fully investigated. This study aimed to clarify the safe management of an IOAL in laparoscopic colorectal surgery. METHODS: One hundred forty-eight consecutive patients who underwent laparoscopic resection with double-stapling technique (DST) anastomosis for left-sided colorectal cancer between April 2015 and June 2016 were included and retrospectively reviewed...
September 22, 2017: Digestive Surgery
Sung Ho Jang, Yun Kyung Jung, Sung Ji Choi, Tae Kyung Ha
When performing laparoscopic gastrectomy, suturing the intestinal anastomosis presents one of the greatest challenges. The V-Loc unidirectional barbed suture has been introduced to eliminate the need to tie knots during closure. This device offers a fast, secure, and effective alternative to conventional suture repair during laparoscopic surgery. However, there have been reported cases of surgical complications associated with the use of barbed suture devices. We describe here a case of small bowel obstruction resulting from improper use of barbed suture during total laparoscopic distal gastrectomy performed for gastric cancer...
May 2017: Annals of Surgical Treatment and Research
Alexandros Charalabopoulos, Bruno Lorenzi, Ali Kordzadeh, Cheuk-Bong Tang, Sritharan Kadirkamanathan, Naga Venkatesh Jayanthi
PURPOSE: Two-stage minimally invasive esophagectomy (MIE) has gained popularity in the surgical treatment of esophageal cancer. MIE's limitation is embedded in the construction of intrathoracic anastomosis. Various anastomotic techniques have been reported; however, the mechanical one remains the most commonly adopted. This pilot study aims to describe an efficient, safe, and reproducible way of performing a hand-sewn intrathoracic esophagogastric anastomosis in conjunction with short-term results using 2D and 3D thoracoscopic approaches...
May 2017: Langenbeck's Archives of Surgery
Odd V Höglund, Oskar Maxon, Anders Grönberg
BACKGROUND: Colorectal cancer is common in humans where treatment involves surgical removal of the cancerous part of the intestines. In the anastomosis procedure a purse-string suture may be time consuming to perform. The aim was to replace the purse-string suture, to develop and test a self-locking loop for temporary sealing of the lumen in colon anastomosis. METHODS: A new device, a flexible band with a locking mechanism was constructed, the I-Tie(®). Small protrusions, designed for increased friction between device and tissue, were added to one side of the flexible band in order to enhance the grip at closure of the loop around tissue...
February 8, 2017: BMC Research Notes
Michael Bartellas, Stephen Ryan, Gregory Doucet, Deanna Murphy, Jacqueline Turner
INTRODUCTION: A realistic hemorrhagic cervical cancer model was three-dimensionally (3D) printed and used in a postgraduate medical simulation training session. MATERIALS AND METHODS: Computer-assisted design (CAD) software was the platform of choice to create and refine the cervical model. Once the prototype was finalized, another software allowed for the addition of a neoplastic mass, which included openings for bleeding from the neoplasm and cervical os. 3D printing was done using two desktop printers and three different materials...
January 1, 2017: Curēus
Kanefumi Yamashita, Shinsuke Takeno, Seiichiro Hoshino, Hironari Shiwaku, Naoya Aisu, Yoichiro Yoshida, Syu Tanimura, Yuichi Yamashita
BACKGROUND: Among all procedures, surgical site infections (SSIs) in colorectal surgery continue to have the highest rate, accounting for 5%-45%. To prevent the bacterial colonization of suture material, which disables local mechanisms of wound decontamination, triclosan-coated sutures were developed. We assessed the effectiveness of triclosan-coated sutures used for skin closure on the rate of SSIs in colorectal cancer surgery. METHODS: Until August 2012, we used conventional methods for skin closure in colorectal cancer surgery at the Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine...
November 2016: Journal of Surgical Research
Eduardo Villanueva-Sáenz, Moisés Marino Ramírez-Ramírez, Gregorio Zubieta-O'Farrill, Luis García-Hernández
BACKGROUND: Colorectal surgery has advanced notably since the introduction of the mechanical suture and the minimally invasive approach. Robotic surgery began in order to satisfy the needs of the patient-doctor relationship, and migrating to the area of colorectal surgery. An initial report is presented on the experience of managing colorectal disease using robot-assisted surgery, as well as an analysis of MATERIAL AND METHODS: A retrospective study was conducted in order to review five patients with colorectal disease intervened with a robot-assisted technique during one year in the initial phase of the learning curve...
November 14, 2016: Cirugia y Cirujanos
Huifang Tang, Daniela Massi, Brian A Hemmings, Mario Mandalà, Zhengqiang Hu, Andreas Wicki, Gongda Xue
The transcription factor Twist is an important regulator of cranial suture during embryogenesis. Closure of the neural tube is achieved via Twist-triggered cellular transition from an epithelial to mesenchymal phenotype, a process known as epithelial-mesenchymal transition (EMT), characterized by a remarkable increase in cell motility. In the absence of Twist activity, EMT and associated phenotypic changes in cell morphology and motility can also be induced, albeit moderately, by other transcription factor families, including Snail and Zeb...
September 20, 2016: Oncotarget
Tomoya Tsukada, Masahide Kaji, Jun Kinoshita, Koichi Shimizu
BACKGROUND AND OBJECTIVES: Laparoscopic anastomotic methods are not commonly used because of the cumbersome laparoscopic intracorporeal sutures and tying involved. The barbed suture is one of the various devices developed to simplify the placement of intracorporeal sutures. However, barbed sutures are not commonly used during reconstruction after radical gastrectomy in cancer patients or for single-layer entire-thickness running suturing for intestinal anastomoses. We describe the procedure for using barbed sutures and report on the short-term surgical outcomes...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Masanori Naito, Takahiro Yamanashi, Takatoshi Nakamura, Hirohisa Miura, Atsuko Tsutsui, Takeo Sato, Masahiko Watanabe
INTRODUCTION: Laparoscopic surgery is widely used for the treatment of colorectal cancer, but it is often associated with postoperative anastomotic complications. Generally, gastrointestinal anastomosis for colorectal surgery is performed using mechanical anastomosis with a double stapling technique. Using the automatic suture device with bioabsorbable polyglycolic acid (PGA) felt is expected to adequately reinforce staple lines on fragile tissue, helping to prevent anastomotic complications, including leakage...
February 2017: Asian Journal of Endoscopic Surgery
Xin Xu, Jun Huang, Weiqiang Yin, Xin Zhang, Hanzhang Chen, Lili Mo, Jianxing He
Lung cancer invading pulmonary trunk is a locally advanced condition, which may indicate poor prognosis. Surgical resection of the lesion can significantly improve survival for some patients. Lobectomy/Pneumonectomy with pulmonary arterioplasty via thoracotomy were generally accepted and used in the past. As the rapid development of minimally invasive techniques and devices, pulmonary arterioplasty is feasible via video-assisted thoracic surgery (VATS). However, few studies have reported the VATS surgical techniques...
March 2016: Journal of Thoracic Disease
Xin Xu, Yuan Qiu, Hui Pan, Lili Mo, Hanzhang Chen, Jianxing He
Lung cancer invading the superior vena cava (SVC) is a locally advanced condition, for which poor prognosis is expected with conservative treatment alone. Surgical resection of the lesion can rapidly relieve the symptoms and significantly improve survival for some patients. Replacement, repair and partial resection of SVC via thoracotomy were generally accepted and used in the past. As the rapid development of minimally invasive techniques and devices, partial resection and repair of SVC are feasible via video-assisted thoracic surgery (VATS)...
March 2016: Journal of Thoracic Disease
Andre Luis de Castro Abreu, Osamu Ukimura, Sunao Shoji, Scott Leslie, Sameer Chopra, Arnaud Marien, Toru Matsugasumi, Arjuna Dharmaraja, Kelvin Wong, Natalie Zaba, Yanling Ma, Mihir M Desai, Inderbir S Gill
OBJECTIVES: To evaluate the feasibility of robot-assisted laparoscopic high-intensity focused ultrasound for targeted, extravesical, transmural, full-thickness ablation of intact bladder wall and tumor. METHODS: In three fresh cadavers and one acute porcine model, the transperitoneal robotic approach was used to mobilize the bladder and create a midline cystotomy. "Mimic" bladder tumors (2 tumors/case) were created by robotically suturing a piece of striated muscle (2...
June 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Richard R Uwiera, Rabban Mangat, Sandra Kelly, Trina C Uwiera, Spencer D Proctor
Catheterization of the intestinal lymph trunk in neonatal pigs is a technique allowing for the long-term collection of large quantities of intestinal (central) efferent lymph. Importantly, the collection of central lymph from the intestine enables researchers to study both the mechanisms and lipid constitutes associated with lipid metabolism, intestinal inflammation and cancer metastasis, as well as cells involved in immune function and immunosurveillance. A ventral mid-line surgical approach permits excellent surgical exposure to the cranial abdomen and relatively easy access to the intestinal lymph trunk vessel that lies near the pancreas and the right ventral segment of the portal vein underneath the visceral aspect of the right liver lobe...
March 5, 2016: Journal of Visualized Experiments: JoVE
Ke Chen, Yang He, Jia-Qin Cai, Yu Pan, Di Wu, Ding-Wei Chen, Jia-Fei Yan, Hendi Maher, Yi-Ping Mou
BACKGROUND: Totally laparoscopic distal gastrectomy (TLDG) using intracorporeal anastomosis has gradually developed due to advancements in laparoscopic surgical instruments. However, totally laparoscopic total gastrectomy (TLTG) with intracorporeal esophagojejunostomy (IE) is still uncommon because of technical difficulties. Herein, we evaluated various types of IE after TLTG in terms of the technical aspects. We compared the short-term operative outcomes between TLTG with IE and laparoscopy-assisted total gastrectomy (LATG) with extracorporeal esophagojejunostomy (EE)...
2016: BMC Surgery
Joel D Cooper
Prior to the 20(th) century, the need for surgical procedures on the airway was infrequent and consisted mainly of tracheostomy to relieve airway obstruction or repair of tracheal injuries such as lacerations. Even the ability of tracheal suture lines to heal primarily was viewed with concern due to the rigidity of the tracheal wall, its precarious blood supply and uncertainty as to whether the cartilage components could heal without complications. In the 20(th) century the evolution of tracheal procedures on major airways evolved to meet the challenges provided by the expanding fields of thoracic surgery and advent of mechanical respiratory support with its associated complications...
March 2016: Journal of Thoracic Disease
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