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https://www.readbyqxmd.com/read/28231377/evidence-based-s3-guidelines-for-diagnostics-and-treatment-of-venous-leg-ulcers-answer-to-dr-bertolini
#1
Martino Neumann
The differential diagnosis of a leg ulcer is broad with a great variety of diseases. Beside the well known as venous, arterial, mixed and diabetic most are rare. Prolidase deficiency is one of the rare causes.Nether the less it is an excellent suggestion to add also genetic diseases as prolidae deficiency to this Guideline. The committee will take this for the next revision.Martino Neumann, on behalf of the redaction of the EADF Guideline Diagnosis and Treatment of Venous Leg Ulcers This article is protected by copyright...
February 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28231132/preparation-of-a-breadfruit-flour-bar
#2
Carmen L Nochera, Diane Ragone
Breadfruit is a nutritious, high energy food with a low quantity of protein but excellent protein quality. It has the potential to be developed into desired products which will help increase its utilization and add value to the crop. The overall purposes of this investigation were to develop a portable, nutritious, ready-to-eat breadfruit product (bar), test the sensory qualities of the product, and evaluate the nutritional properties of the product. Flour made from the Micronesian variety, Meinpadahk (Artocarpus altilis × Artocarpus mariannensis), was utilized for the development of the breadfruit bar...
May 20, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230631/aerobic-exercise-and-its-effects-on-cognition-in-schizophrenia
#3
Peter Falkai, Berend Malchow, Andrea Schmitt
PURPOSE OF REVIEW: Schizophrenia is a severe neuropsychiatric disorder with incomplete remission because of negative and cognitive symptoms in a large proportion of patients. Antipsychotic medication is successful in modulating positive symptoms, but only to a lower extent negative symptoms including cognitive dysfunction. Therefore, development of innovative add-on treatment is highly needed. In this review, recent evidence from clinical studies reveals effects of aerobic exercise on cognitive deficits in schizophrenia patients...
February 21, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28230623/safety-and-accuracy-of-freehand-versus-navigated-iliac-screws-results-from-222-screw-placements
#4
Randall J Hlubek, Kaith K Almefty, David S Xu, Jay D Turner, U Kumar Kakarla
STUDY DESIGN: Retrospective review. OBJECTIVE: To compare the safety and accuracy of the freehand technique versus stereotactic navigation for placement of iliac screws. SUMMARY OF BACKGROUND DATA: Iliac screw fixation is often used to augment lumbosacral reconstruction in advanced spine disease to increase the likelihood of successful arthrodesis. Iliac screws can be placed with image guidance, using either intraoperative fluoroscopy or computed tomography (CT) to guide navigation...
February 22, 2017: Spine
https://www.readbyqxmd.com/read/28230449/real-world-glycemic-control-from-glp-1ra-therapy-with-and-without-concurrent-insulin-in-patients-with-type-2-diabetes
#5
Mukul Singhal, Sudhir Unni, Marisa Schauerhamer, Hiep Nguyen, Jeff Hurd, Carrie McAdam-Marx
BACKGROUND: Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are recommended as add-on therapy in patients with uncontrolled type 2 diabetes (T2D), with no specific guidance as to timing versus insulin. Furthermore, real-world data assessing GLP-1RA outcomes with or without concurrent insulin therapy are lacking. OBJECTIVE: To identify glycemic response with GLP-1RAs by insulin use in patients with T2D at 1-year follow-up to inform decisions regarding GLP-1RA use with or without insulin...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28230417/aging-and-half-ironman-performance
#6
M J Stones, Adric Hartin
: Background/Study Context: Previous research on triathlon performance analyzed age trends for the Top Ten or Top Five finishers in world championship or national races at Olympic, Half-Ironman, and Ironman distances. The findings indicated higher age declines and/or earlier onset of decline in swimming and running than cycling. However, the designs of those studies took no account of possible differences between cross-sectional and longitudinal trends (i.e., cohort differences versus age changes)...
March 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28230275/the-development-and-correlates-of-gender-role-attitudes-in-african-american-youth
#7
Chun Bun Lam, Christine Stanik, Susan M McHale
This research examined the longitudinal trajectories and family correlates of gender role attitudes in African American youth in a sample of 166 sibling pairs residing with their mothers and fathers. Multilevel modelling revealed that (1) girls and boys exhibited significant declines in gender attitude traditionality from ages 9 to 15 that levelled off through age 18, (2) mothers' (but not fathers') gender role attitude traditionality was positively related to youth's attitude traditionality, and (3) within-person variation in mothers' (but not fathers') racial discrimination experiences was negatively related to within-person variation in youth's gender role attitude traditionality...
February 23, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28230252/randomized-double-blind-placebo-controlled-phase-2-study-of-ganaxolone-as-add-on-therapy-in-adults-with-uncontrolled-partial-onset-seizures
#8
Michael R Sperling, Pavel Klein, Julia Tsai
OBJECTIVE: To evaluate the efficacy and safety of ganaxolone as adjunctive therapy in adults with uncontrolled partial-onset seizures despite taking up to three concomitant antiepileptic drugs (AEDs). METHODS: Adults aged 18-69 years and refractory to conventional AEDs were enrolled in a multicenter, double-blind, placebo-controlled trial. After an 8-week baseline period, patients were randomized 2:1 to ganaxolone 1,500 mg/day or placebo for a 10-week treatment period (2-week forced titration and 8-week maintenance) followed by either tapering or entry into an open-label extension study...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28230112/meteorology-high-winds-add-to-extreme-deluges
#9
(no author information available yet)
No abstract text is available yet for this article.
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28229955/three-dimensional-colloidal-lithography
#10
Hironori Nagai, Austen Poteet, Xu A Zhang, Chih-Hao Chang
Light interactions with colloidal particles can generate a variety of complex three-dimensional (3D) intensity patterns, which can be utilized for nanolithography. The study of particle-light interactions can add more types of intensity patterns by manipulating key factors. Here we investigate a novel 3D nanolithography technique using colloidal particles under two-beam coherent illuminations. The fabricated 3D nanostructures are hollow, nested within periodic structures, and possess multiple chamber geometry...
February 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28229846/-diagnostic-and-therapeutic-approach-of-chronic-spontaneous-urticaria-recommendations-in-portugal
#11
Célia Costa, Margarida Gonçalo
Chronic spontaneous urticaria is a complex disorder, of unclear etiology, easily diagnosed although often difficult to treat. It has a significant impact on the patients' quality of life and results in high direct and indirect costs. The diagnosis of chronic spontaneous urticaria is mainly clinical and a limited number of tests is recommended for differential diagnosis and/or for the investigation/exclusion of possible causes. In addition to the complete blood count and C-reactive protein, and/or erythrocyte sedimentation rate, additional tests must be selected according to clinical criteria...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28229577/maximal-aerobic-capacity-can-be-increased-by-enhancing-performers-expectancies
#12
Jeff Montes, Gabriele Wulf, James W Navalta
BACKGROUND: Maximum aerobic capacity (VO2max) is widely accepted as the best measure of cardiovascular fitness and aerobic power. The present study investigated whether enhancing participants' performance expectancies through positive social-comparative feedback would increase VO2max. METHODS: Participants were experienced runners who regularly ran for exercise or competitively. All participants completed two VO2max tests within a 2-week period at similar times of the day...
February 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28229273/effect-of-exercise-on-diastolic-function-in-heart-failure-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
M J Pearson, S F Mungovan, N A Smart
Diastolic dysfunction contributes to the development and progression of heart failure. Conventional echocardiography and tissue Doppler imaging are widely utilised in clinical research providing a number of indices of diastolic function valuable in the diagnosis and prognosis of heart failure patients. The aim of this meta-analysis was to quantify the effect of exercise training on diastolic function in patients with heart failure. Exercise training studies that investigate different indices of diastolic function in patients with heart failure have reported that exercise training improves diastolic function in these patients...
February 23, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28228966/objective-image-analysis-of-real-time-three-dimensional-intraoperative-ultrasound-for-intrinsic-brain-tumour-surgery
#14
Sophie J Camp, Vasileios Apostolopoulos, Vasileios Raptopoulos, Amrish Mehta, Kevin O'Neill, Mohammed Awad, Babar Vaqas, David Peterson, Federico Roncaroli, Dipankar Nandi
BACKGROUND: There is growing evidence that maximal surgical resection of primary intrinsic brain tumours is beneficial, both by improving progression free and overall survival and also by facilitating postoperative chemotherapy and radiotherapy. Hence, there has been an increase in the popularity of real-time intraoperative imaging in brain tumour surgery. The complex theatre arrangements, prohibitive cost and prolonged theatre time of intraoperative MRI have restricted its application...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28228723/presynaptic-muscarinic-acetylcholine-receptors-and-trkb-receptor-cooperate-in-the-elimination-of-redundant-motor-nerve-terminals-during-development
#15
Laura Nadal, Neus Garcia, Erica Hurtado, Anna Simó, Marta Tomàs, Maria A Lanuza, Victor Cilleros, Josep Tomàs
The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28228525/chirality-induced-spin-polarization-places-symmetry-constraints-on-biomolecular-interactions
#16
Anup Kumar, Eyal Capua, Manoj K Kesharwani, Jan M L Martin, Einat Sitbon, David H Waldeck, Ron Naaman
Noncovalent interactions between molecules are key for many biological processes. Necessarily, when molecules interact, the electronic charge in each of them is redistributed. Here, we show experimentally that, in chiral molecules, charge redistribution is accompanied by spin polarization. We describe how this spin polarization adds an enantioselective term to the forces, so that homochiral interaction energies differ from heterochiral ones. The spin polarization was measured by using a modified Hall effect device...
February 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28228069/recent-advances-in-the-gastric-mucosal-protection-against-stress-induced-gastric-lesions-importance-of-renin-angiotensin-vasoactive-metabolites-gaseous-mediators-and-appetite-peptides
#17
Tomasz Brzozowski, Katarzyna Magierowska, Marcin Magierowski, Agata Ptak-Belowska, Robert Pajdo, Slawomir Kwiecien, Rafal Olszanecki, Ryszard Korbut
Stress is known to cause severe adverse effects in the human gastrointestinal tract including mucosal microbleedings and erosions or even gastric ulceration but the mechanism of these complications has not been fully elucidated. The pathogenesis of stress-induced gastric damage involves the fall in gastric blood flow (GBF), an increase in gastric acid secretion and gastric motility, enhanced adrenergic and cholinergic nerve activity and the rise in gastric mucosal generation of reactive oxygen species. The gastric mucosal defense mechanisms against the deleterious effect of stress include the activation of the hypothalamic-pituitary-adrenal axis which has been linked with glucocorticoids release capable of counteracting of stress-induced gastric lesions...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28227892/investigation-of-changes-in-the-electrical-properties-of-novel-knitted-conductive-textiles-during-cyclic-loading
#18
Cristina Isaia, Donal McNally, Simon A McMaster, David T Branson, Cristina Isaia, Donal McNally, Simon A McMaster, David T Branson, Simon A McMaster, Donal McNally, Cristina Isaia, David T Branson
Combining stainless steel with polyester fibres adds an attractive conductive behaviour to the yarn. Once knitted in such a manner, fabrics develop sensing properties that make the textiles, also known as e-textiles, suitable for smart/wearable applications. Structural deformations of the fibres (e.g. stretching) will cause changes in the conductivity of the fabric. This work investigates changes in the electrical properties exhibited by four knitted conductive textiles made of 20% stainless steel and 80% polyester fibres during cyclic loading...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227686/novel-modular-2-dof-microsurgical-forceps-for-transoral-laser-microsurgeries-ergonomic-design-and-preliminary-evaluation
#19
Manish Chauhan, Giacinto Barresi, Nikhil Deshpande, Darwin G Caldwell, Leonardo S Mattos, Manish Chauhan, Giacinto Barresi, Nikhil Deshpande, Darwin G Caldwell, Leonardo S Mattos, Darwin G Caldwell, Giacinto Barresi, Leonardo S Mattos, Nikhil Deshpande, Manish Chauhan
Transoral Laser Microsurgeries (TLM) demand a great level of control and precision in intraoperative tissue manipulation. The optimal eradication of the diseased tissue is possible only with coordinated control of the laser aiming for incision and the microsurgical tools for orienting and stretching the tissue. However, the traditional microsurgical tools are long, single purpose, one degree-of-freedom (DOF), rigid tools with small range of motion and a normal grasping handle inducing non-ergonomic usage. This paper presents a novel, modular microsurgical tool to overcome the challenges of the traditional tools and improve the surgeon-tool usage experience...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227551/detecting-slow-eye-movement-for-recognizing-driver-s-sleep-onset-period-with-eeg-features
#20
Yingying Jiao, Bao-Liang Lu, Yingying Jiao, Bao-Liang Lu, Baa-Liang Lu, Yingying Jiao
Slow eye movement (SEM) is reported as a reliable indicator of sleep onset period (SOP) in sleep researches, but its characteristics and functions for detecting driving fatigue have not been fully studied. Through visual observations on ten subjects' experimental data, we found that SEMs tend to occur during eye closure events (ECEs). SEMs accompanied with alpha wave's attenuation during simulated driving was observed in our study. We used box plots to analyze the distribution of durations of different ECEs to measure sleepiness level...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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