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https://www.readbyqxmd.com/read/28935928/location-of-cerebral-microbleeds-and-their-association-with-carotid-intima-media-thickness-a-community-based-study
#1
Chih-Ping Chung, Kun-Hsien Chou, Wei-Ta Chen, Li-Kuo Liu, Wei-Ju Lee, An-Chun Huang, Liang-Kung Chen, Ching-Po Lin, Pei-Ning Wang
To assess whether high cerebral microbleeds (CMBs) are associated with carotid intima-media thickness (CIMT), a marker of systemic atherosclerosis, we cross-sectionally evaluated participants from a community-based study, the I-Lan Longitudinal Aging Study. The participants' demographics and cardiovascular risk factors were determined by questionnaire and/or laboratory measurements. CIMT was measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3 T MRI. Of the 962 subjects [62...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928164/immunopet-of-malignant-and-normal-b-cells-with%C3%A2-89-zr-and%C3%A2-124-i-labeled-obinutuzumab-antibody-fragments-reveals-differential-cd20-internalization-in-vivo
#2
Kirstin A Zettlitz, Richard Tavare, Scott M Knowles, Kristopher K Steward, John M Timmerman, Anna M Wu
PURPOSE: The B-cell antigen CD20 provides a target for antibody-based positron emission tomography (immunoPET). We engineered antibody fragments targeting human CD20 and studied their potential as immunoPET tracers in transgenic mice (huCD20TM) and in a murine lymphoma model expressing human CD20. EXPERIMENTAL DESIGN: Anti-CD20 cys-diabody (cDb) and cys-minibody (cMb) based on rituximab (Rx) and obinutuzumab (GA101) were radioiodinated and used for immunoPET imaging of a murine lymphoma model...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28910373/lack-of-association-of-mri-determined-subclinical-cardiovascular-disease-with-dizziness-and-vertigo-in-a-cross-sectional-population-based-study
#3
Roberto Lorbeer, Holger Hetterich, Ralf Strobl, Anina Schafnitzel, Hannah Patscheider, Andreas Schindler, Katharina Müller-Peltzer, Wieland Sommer, Annette Peters, Christa Meisinger, Margit Heier, Wolfgang Rathmann, Fabian Bamberg, Eva Grill
OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness...
2017: PloS One
https://www.readbyqxmd.com/read/28904646/participation-in-a-year-long-cure-embedded-into-major-core-genetics-and-cellular-and-molecular-biology-laboratory-courses-results-in-gains-in-foundational-biological-concepts-and-experimental-design-skills-by-novice-undergraduate-researchers
#4
Marcy A Peteroy-Kelly, Matthew R Marcello, Erika Crispo, Zafir Buraei, Daniel Strahs, Marisa Isaacson, Leslie Jaworski, David Lopatto, David Zuzga
This two-year study describes the assessment of student learning gains arising from participation in a year-long curriculum consisting of a classroom undergraduate research experience (CURE) embedded into second-year, major core Genetics and Cellular and Molecular Biology (CMB) laboratory courses. For the first course in our CURE, students used micro-array or RNAseq analyses to identify genes important for environmental stress responses by Saccharomyces cerevisiae. The students were tasked with creating overexpressing mutants of their genes and designing their own original experiments to investigate the functions of those genes using the overexpression and null mutants in the second CURE course...
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28893764/prevalence-of-cerebral-microbleeds-in-patients-with-continuous-flow-left-ventricular-assist-devices
#5
Daisuke Yoshioka, Shuhei Okazaki, Koichi Toda, Sho Murase, Shunsuke Saito, Keitaro Domae, Shigeru Miyagawa, Yasushi Yoshikawa, Takashi Daimon, Manabu Sakaguchi, Yoshiki Sawa
BACKGROUND: The prevalence of cerebral microbleeds (CMBs) in gradient echo T2*-weighted brain MRI has a positive correlation with hemorrhagic stroke incidence. However, the prevalence of CMBs in patients with left ventricular assist devices (LVADs) has not been evaluated. We evaluated the prevalence of CMBs and the relationship with hemorrhagic stroke incidence in patients with LVADs. METHOD AND RESULTS: We analyzed results from brain MRI in prospective examinations of 35 consecutive patients who had undergone LVAD explantation for heart transplantation or recovery since 2011...
September 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28884255/using-the-chemical-mass-balance-model-to-estimate-voc-source-contributions-in-newly-built-timber-frame-houses-a-case-study
#6
Herve Plaisance, Pierre Mocho, Nicolas Sauvat, Jane Vignau-Laulhere, Katarzyna Raulin, Valerie Desauziers
Basing on the material emission data obtained in a test chamber, chemical mass balance (CMB) was used to assess the source apportionment of volatile organic compound (VOC) concentrations in three newly built timber frame houses. CMB has been proven to be able to discriminate the source contributions for two contrasted environmental conditions (with and without ventilation). The shutdown of the ventilation system caused an increase in the VOC concentrations due to the increased contribution of indoor surface materials like the door material and furniture explaining together over 65% of total VOCs...
September 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28873663/chemical-composition-and-redox-activity-of-pm0-25-near-los-angeles-international-airport-and-comparisons-to-an-urban-traffic-site
#7
Farimah Shirmohammadi, Christopher Lovett, Mohammad Hossein Sowlat, Amirhosein Mousavi, Vishal Verma, Martin M Shafer, James J Schauer, Constantinos Sioutas
To investigate the relative impacts of emissions from Los Angeles International Airport (LAX), as well as the impacts of traffic emissions from freeways, on the oxidative potential of particulate matter (PM), PM0.25 were collected at two urban background locations in Los Angeles. Redox activity of the PM samples was measured by means of an in vitro alveolar macrophage assay that quantifies the formation of reactive oxygen species (ROS) in cells, and detailed chemical analyses were performed to determine the speciated chemical composition of collected PM...
August 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28831797/cytochalasins-from-an-australian-marine-sediment-derived-phomopsis-sp-cmb-m0042f-acid-mediated-intramolecular-cycloadditions-enhance-chemical-diversity
#8
Zhuo Shang, Ritesh Raju, Angela A Salim, Zeinab G Khalil, Robert J Capon
Chemical analysis of an Australian coastal marine sediment-derived fungus, Phomopsis sp. (CMB-M0042F), yielded the known cytochalasins J (1) and H (2), together with five new analogues, cytochalasins J1-J3 (3-5) and H1 and H2 (6 and 7). Structures of 1-7 were assigned on the basis of detailed spectroscopic analysis, chemical interconversion, and biosynthetic and mechanistic considerations. Of note, 1 and 2 proved to be highly sensitive to acid-mediated transformation, with 1 affording 3-5 and 2 affording 6 and 7...
August 31, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28827133/biochemical-characterization-of-a-novel-thermostable-chitinase-from-hydrogenophilus-hirschii-strain-kb-dz44
#9
Khelifa Bouacem, Hassiba Laribi-Habchi, Sondes Mechri, Hocine Hacene, Bassem Jaouadi, Amel Bouanane-Darenfed
An extracellular acido-thermostable endo-chitinase (called ChiA-Hh59) from thermophilic Hydrogenophilus hirschii strain KB-DZ44, was purified and characterized. The maximum chitinase activity recorded after 36-h of incubation at 60°C was 3000U/ml. Pure enzyme was obtained after heat and acidic treatment, precipitation by ammonium sulphate and acetone, respectively, followed by sequential column chromatographies on Sephacryl S-200 and Mono Q-Sepharose. Based on MALDI-TOF/MS analysis, the purified enzyme is a monomer with a molecular mass of 59103...
August 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800410/incident-risk-and-progression-of-cerebral-microbleeds-in-healthy-adults-a-multi-occasion-longitudinal-study
#10
Ana M Daugherty, Naftali Raz
Decline in cerebrovascular health complicates brain aging, and development of cerebral microbleeds (CMBs) is one of its prominent indicators. In a large sample of healthy adults (N = 251, age 18-78 years at baseline, 70% women), the contributions of chronological age and vascular health indicators to the risk of developing a CMB, as well as the change in CMB size and iron content, were examined in a prospective 8-year longitudinal study using susceptibility weighted imaging. Twenty-six persons (10.4%), most of whom were 40 years of age or older, had at least 1 CMB during the study...
July 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28797254/relationship-between-radiation-dose-and-microbleed-formation-in-patients-with-malignant-glioma
#11
Michael Wahl, Mekhail Anwar, Christopher P Hess, Susan M Chang, Janine M Lupo
BACKGROUND: Cranial irradiation is associated with long-term cognitive changes. Cerebral microbleeds (CMBs) have been identified on susceptibility-weighted MRI (SWI) in patients who have received prior cranial radiation, and serve as radiographic markers for microvascular injury thought to contribute to late cognitive decline. The relationship between CMB formation and radiation dose has not previously been quantified. METHODS: SWI was performed on 13 patients with stable WHO grade III-IV gliomas between 2 and 4 years after chemoradiotherapy to 60 Gy...
August 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28782864/sex-dependent-effects-of-uric-acid-on-cerebral-microbleed-a-cross-sectional-study-in-the-general-population
#12
S-M Jeong, T G Yoo, Y-S Nam, S H Kim, J E Lee, S Kim, J-S Lim, H-M Kwon, J-H Park
BACKGROUND AND PURPOSE: Elevated serum uric acid (UA) is known to be associated with stroke. However, there is little information on the association between serum UA levels and cerebral microbleed (CMB), a precursor of stroke. Therefore, we investigated the association between UA and CMB in a general population taking into consideration sex-related differences. METHODS: The subjects in this cross-sectional study consisted of 2686 individuals of 40-79 years of age (1403 men and 1283 women) who underwent regular health screenings, including brain magnetic resonance imaging, at Seoul National University Hospital Health Promotion Center...
August 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28760970/habitual-sleep-as-a-contributor-to-racial-differences-in-cardiometabolic-risk
#13
David S Curtis, Thomas E Fuller-Rowell, Mona El-Sheikh, Mercedes R Carnethon, Carol D Ryff
Insufficient and disrupted sleep is linked with cardiovascular and metabolic dysregulation and morbidity. The current study examines the degree to which differences in sleep between black/African American (AA) and white/European American (EA) adults explain racial differences in cardiometabolic (CMB) disease risk. Total sleep time and sleep efficiency (percent of time in bed asleep) were assessed via seven nights of wrist actigraphy among 426 participants in the Midlife in the United States Study (31% AA; 69% EA; 61% female; mean age = 56...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28753363/detecting-patchy-reionization-in-the-cosmic-microwave-background
#14
Kendrick M Smith, Simone Ferraro
Upcoming cosmic microwave background (CMB) experiments will measure temperature fluctuations on small angular scales with unprecedented precision. Small-scale CMB fluctuations are a mixture of late-time effects: gravitational lensing, Doppler shifting of CMB photons by moving electrons [the kinematic Sunyaev-Zel'dovich (KSZ) effect], and residual foregrounds. We propose a new statistic which separates the KSZ signal from the others, and also allows the KSZ signal to be decomposed in redshift bins. The decomposition extends to high redshift and does not require external data sets such as galaxy surveys...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28747441/brain-hemorrhage-recurrence-small-vessel-disease-type-and-cerebral-microbleeds-a-meta-analysis
#15
REVIEW
Andreas Charidimou, Toshio Imaizumi, Solene Moulin, Alexandro Biffi, Neshika Samarasekera, Yusuke Yakushiji, Andre Peeters, Yves Vandermeeren, Patrice Laloux, Jean-Claude Baron, Mar Hernandez-Guillamon, Joan Montaner, Barbara Casolla, Simone M Gregoire, Dong-Wha Kang, Jong S Kim, H Naka, Eric E Smith, Anand Viswanathan, Hans R Jäger, Rustam Al-Shahi Salman, Steven M Greenberg, Charlotte Cordonnier, David J Werring
OBJECTIVE: We evaluated recurrent intracerebral hemorrhage (ICH) risk in ICH survivors, stratified by the presence, distribution, and number of cerebral microbleeds (CMBs) on MRI (i.e., the presumed causal underlying small vessel disease and its severity). METHODS: This was a meta-analysis of prospective cohorts following ICH, with blood-sensitive brain MRI soon after ICH. We estimated annualized recurrent symptomatic ICH rates for each study and compared pooled odds ratios (ORs) of recurrent ICH by CMB presence/absence and presumed etiology based on CMB distribution (strictly lobar CMBs related to probable or possible cerebral amyloid angiopathy [CAA] vs non-CAA) and burden (1, 2-4, 5-10, and >10 CMBs), using random effects models...
August 22, 2017: Neurology
https://www.readbyqxmd.com/read/28739409/fabrication-of-au-iii-ion-imprinted-polymer-based-on-thiol-modified-chitosan
#16
M Monier, D A Abdel-Latif
Au(III) ions were selectively extracted from aqueous media using Au(III) ion-imprinted bio-adsorbent based on modified chitosan (Au-CMB). First, 2-mercaptobenzaldehyde-chitosan Schiff base was prepared and interacted with Au(III) ions. The obtained polymeric Au(III) complex was then cross-linked by epichlorohydrin (ECH) before leaching the template Au(III) ions out of the cross-linked matrix. During the synthetic procedures, the obtained chitosan derivatives were characterized by Elemental analysis, FTIR and NMR spectra...
July 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28738060/community-detection-in-sequence-similarity-networks-based-on-attribute-clustering
#17
Janamejaya Chowdhary, Frank E Löffler, Jeremy C Smith
Networks are powerful tools for the presentation and analysis of interactions in multi-component systems. A commonly studied mesoscopic feature of networks is their community structure, which arises from grouping together similar nodes into one community and dissimilar nodes into separate communities. Here, the community structure of protein sequence similarity networks is determined with a new method: Attribute Clustering Dependent Communities (ACDC). Sequence similarity has hitherto typically been quantified by the alignment score or its expectation value...
2017: PloS One
https://www.readbyqxmd.com/read/28720659/microbleeds-cerebral-hemorrhage-and-functional-outcome-after-stroke-thrombolysis-individual-patient-data-meta-analysis
#18
Andreas Charidimou, Guillaume Turc, Catherine Oppenheim, Shenqiang Yan, Jan F Scheitz, Hebun Erdur, Pascal P Klinger-Gratz, Marwan El-Koussy, Wakoh Takahashi, Yusuke Moriya, Duncan Wilson, Chelsea S Kidwell, Jeffrey L Saver, Asma Sallem, Solene Moulin, Myriam Edjlali-Goujon, Vincent Thijs, Zoe Fox, Ashkan Shoamanesh, Gregory W Albers, Heinrich P Mattle, Oscar R Benavente, H Rolf Jäger, Gareth Ambler, Junya Aoki, Jean-Claude Baron, Kazumi Kimura, Wataru Kakuda, Shunya Takizawa, Simon Jung, Christian H Nolte, Min Lou, Charlotte Cordonnier, David J Werring
BACKGROUND AND PURPOSE: We assessed whether the presence, number, and distribution of cerebral microbleeds (CMBs) on pre-intravenous thrombolysis MRI scans of acute ischemic stroke patients are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome. METHODS: We performed an individual patient data meta-analysis, including prospective and retrospective studies of acute ischemic stroke treated with intravenous tissue-type plasminogen activator...
July 18, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28717091/thrombolysis-related-multiple-lobar-hemorrhaging-in-cerebral-amyloid-angiopathy-with-extensive-strictly-lobar-cerebral-microbleeding
#19
Makoto Eriguchi, Yusuke Yakushiji, Jun Tanaka, Masashi Nishihara, Hideo Hara
A hemi-paralyzed 86-year-old man was diagnosed with ischemic stroke and underwent thrombolysis. Pre-thrombolysis brain magnetic resonance imaging revealed extensive strictly lobar cerebral microbleeding (CMB). Post-thrombolytic computed tomography revealed asymptomatic multiple intracerebral hemorrhaging (ICH). His age, CMB topography, and decreased cerebral spinal fluid amyloid-β 40 and 42 levels were compatible with a diagnosis of cerebral amyloid angiopathy (CAA). There is no consensus on the safety of thrombolysis for acute stroke patients with CAA...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28707246/chemical-characterization-and-receptor-modeling-of-pm10-in-the-surroundings-of-the-opencast-lignite-mines-of-western-macedonia-greece
#20
Constantini Samara, George Argyropoulos, Theodoros Grigoratos, Αthanasios Kouras, Εvangelia Manoli, Symela Andreadou, Fragkiskos Pavloudakis, Chariton Sahanidis
The Western Macedonian Lignite Center (WMLC) in northwestern Greece is the major lignite center in the Balkans feeding four major power plants of total power exceeding 4 GW. Concentrations of PM10 (i.e., particulate matters with diameters ≤10 μm) are the main concern in the region, and the high levels observed are often attributed to the activities related to power generation. In this study, the contribution of fugitive dust emissions from the opencast lignite mines to the ambient levels of PM10 in the surroundings was estimated by performing chemical mass balance (CMB) receptor modeling...
July 13, 2017: Environmental Science and Pollution Research International
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