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https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#1
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28076478/liver-transplantation-for-carcinoma-hepatocellular-in-s%C3%A3-o-paulo-414-cases-by-the-milan-brazil-criteria
#2
Gustavo Pilotto D Sá, Fernando P P Vicentine, Alcides A Salzedas-Netto, Carla Adriana Loureiro de Matos, Luiz R Romero, Dario F P Tejada, Paulo Celso Bosco Massarollo, Gaspar J Lopes-Filho, Adriano M Gonzalez
Background: The criterion of Milan (CM) has been used as standard for indication of liver transplantation (LTx) for hepatocellular carcinoma (HCC) worldwide for nearly 20 years. Several centers have adopted criteria expanded in order to increase the number of patients eligible to liver transplantation, while maintaining good survival rates. In Brazil, since 2006, the criterion of Milan/Brazil (CMB), which disregards nodules <2 cm, is adopted, including patients with a higher number of small nodules...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28063711/fine-particulates-over-south-asia-review-and-meta-analysis-of-pm2-5-source-apportionment-through-receptor-model
#3
Nandita Singh, Vishnu Murari, Manish Kumar, S C Barman, Tirthankar Banerjee
Fine particulates (PM2.5) constitute dominant proportion of airborne particulates and have been often associated with human health disorders, changes in regional climate, hydrological cycle and more recently to food security. Intrinsic properties of particulates are direct function of sources. This initiates the necessity of conducting a comprehensive review on PM2.5 sources over South Asia which in turn may be valuable to develop strategies for emission control. Particulate source apportionment (SA) through receptor models is one of the existing tool to quantify contribution of particulate sources...
January 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28062861/incidence-locations-and-longitudinal-course-of-cerebral-microbleeds-in-european-moyamoya
#4
Holger Wenz, Ralf Wenz, Máté Maros, Gregory Ehrlich, Mansour Al-Zghloul, Christoph Groden, Alex Förster
BACKGROUND AND PURPOSE: Cerebral microbleeds (cMBs) have previously been linked with especially high incidence in Asian patients with moyamoya together with high tendency to bleed. This, presumably, is characteristic of patients with moyamoya. Herein, we, therefore, investigate retrospectively the frequency, location, and longitudinal course of cMBs in a large German cohort. METHODS: We included all patients with moyamoya who underwent standard magnetic resonance imaging, including T2*-weighted images, in our department between 1998 and 2015...
January 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28058837/talarazines-a-e-noncytotoxic-iron-iii-chelators-from-an-australian-mud-dauber-wasp-associated-fungus-talaromyces-sp-cmb-w045
#5
Pabasara Kalansuriya, Michelle Quezada, Breno P Espósito, Robert J Capon
Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A-E (1-5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3 Marfey's method. We report on the noncytotoxic Fe(III) chelation properties of 1-8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media...
January 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28027966/sequence-motifs-associated-with-paternal-transmission-of-mitochondrial-dna-in-the-horse-mussel-modiolus-modiolus-bivalvia-mytilidae
#6
Brent M Robicheau, Sophie Breton, Donald T Stewart
In the majority of metazoans paternal mitochondria represent evolutionary dead-ends. In many bivalves, however, this paradigm does not hold true; both maternal and paternal mitochondria are inherited. Herein, we characterize maternal and paternal mitochondrial control regions of the horse mussel, Modiolus modiolus (Bivalvia: Mytilidae). The maternal control region is 808bp long, while the paternal control region is longer at 2.3kb. We hypothesize that the size difference is due to a combination of repeated duplications within the control region of the paternal mtDNA genome, as well as an evolutionarily ancient recombination event between two sex-associated mtDNA genomes that led to the insertion of a second control region sequence in the genome that is now transmitted via males...
December 24, 2016: Gene
https://www.readbyqxmd.com/read/28004242/targeted-myocardial-delivery-of-gdf11-gene-rejuvenates-the-aged-mouse-heart-and-enhances-myocardial-regeneration-after-ischemia-reperfusion-injury
#7
Guo-Qing Du, Zheng-Bo Shao, Jie Wu, Wen-Juan Yin, Shu-Hong Li, Jun Wu, Richard D Weisel, Jia-Wei Tian, Ren-Ke Li
Ischemic cardiac injury is the main contributor to heart failure, and the regenerative capacity of intrinsic stem cells plays an important role in tissue repair after injury. However, stem cells in aged individuals have reduced regenerative potential and aged tissues lack the capacity to renew. Growth differentiation factor 11 (GDF11), from the activin-transforming growth factor β superfamily, has been shown to promote stem cell activity and rejuvenation. We carried out non-invasive targeted delivery of the GDF11 gene to the heart using ultrasound-targeted microbubble destruction (UTMD) and cationic microbubble (CMB) to investigate the ability of GDF11 to rejuvenate the aged heart and improve tissue regeneration after injury...
January 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27936213/radiologic-histopathologic-correlation-of-cerebral-microbleeds-using-pre-mortem-and-post-mortem-mri
#8
Sven Haller, Marie-Louise Montandon, François Lazeyras, Max Scheffler, Stephan Meckel, Francois R Herrmann, Panteleimon Giannakopoulos, Enikö Kövari
INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation...
2016: PloS One
https://www.readbyqxmd.com/read/27905358/-do-cerebral-microbleeds-increase-the-risk-of-hemorrhagic-complications-of-thrombolytic-therapy
#9
T A Polyakova, A V Arablinsky, O S Levin
The role of the cerebral microbleeds (CMB) as a potential predictor of hemorrhagic complications of thrombolytic therapy is discussed. CMB are small perivascular hemosiderin deposits in the brain detected by magnetic resonance imaging in gradient echo T2* or SWI sequences. They are associated (along with leukoaraiosis or lacunes) with cerebral microangiopathies. Most often CMB are associated with hypertensive arteriopathy (the main cause of CMB localization) or cerebral amyloid angiopathy (the main cause of cerebral CMB)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905355/-cerebral-microbleeds-in-cerebrovascular-and-neurodegenerative-diseases-with-cognitive-impairment
#10
T A Polyakova, O S Levin
AIM: To study a role of cerebral microbleeds (CMB) in the diagnosis of main cerebrovascular and neurodegenerative diseases with cognitive impairment. MATERIAL AND METHODS: CMB were studied in 120 patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and vascular dementia using 1.5T MRI in T2 * gradient echo. An impact of CMB on cognitive functions and the relationship with signs of vascular and neurodegenerative lesions of the brain were studied as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27898582/antithrombotic-therapy-in-patients-with-cerebral-microbleeds
#11
Duncan Wilson, David J Werring
PURPOSE OF REVIEW: Cerebral microbleeds (CMBs) are a radiological marker of cerebral small vessel disease corresponding to small haemosiderin foci identified by blood-sensitive MRI. CMBs are common in older community populations, and in individuals with ischaemic stroke or transient ischaemic attack (TIA), and intracerebral haemorrhage (ICH). We summarize how CMBs might contribute to assessing the future risk of ischaemic stroke and ICH to inform antithrombotic (antiplatelet or anticoagulant) decisions...
February 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27884527/source-apportionment-of-size-fractionated-particles-during-the-2013-asian-youth-games-and-the-2014-youth-olympic-games-in-nanjing-china
#12
Pulong Chen, Tijian Wang, Xiaobo Lu, Yiyong Yu, Matthew Kasoar, Min Xie, Bingliang Zhuang
In this study, samples of size-fractionated particulate matter were collected continuously using a 9-size interval cascade impactor at an urban site in Nanjing, before, during and after the Asian Youth Games (AYG), from July to September of 2013, and the Youth Olympic Games (YOG), from July to September of 2014. First, elemental concentrations, water-soluble ions including Cl(-), NO3(-), SO4(2-), NH4(+), K(+), Na(+) and Ca(2+), organic carbon (OC) and elemental carbon (EC) were analysed. Then, the source apportionment of the fine and coarse particulate matter was carried out using the chemical mass balance (CMB) model...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27807676/pm2-5-pollution-from-household-solid-fuel-burning-practices-in-central-india-2-application-of-receptor-models-for-source-apportionment
#13
Jeevan Lal Matawle, Shamsh Pervez, Manas Kanti Deb, Anjali Shrivastava, Suresh Tiwari
USEPA's UNMIX, positive matrix factorization (PMF) and effective variance-chemical mass balance (EV-CMB) receptor models were applied to chemically speciated profiles of 125 indoor PM2.5 measurements, sampled longitudinally during 2012-2013 in low-income group households of Central India which uses solid fuels for cooking practices. Three step source apportionment studies were carried out to generate more confident source characterization. Firstly, UNMIX6.0 extracted initial number of source factors, which were used to execute PMF5...
November 2, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27797756/mitos-jl-mutual-information-tools-for-protein-sequence-analysis-in-the-julia-language
#14
Diego J Zea, Diego Anfossi, Morten Nielsen, Cristina Marino-Buslje
MOTIVATION: MIToS is an environment for mutual information analysis and a framework for protein multiple sequence alignments (MSAs) and protein structures (PDB) management in Julia language. It integrates sequence and structural information through SIFTS, making Pfam MSAs analysis straightforward. MIToS streamlines the implementation of any measure calculated from residue contingency tables and its optimization and testing in terms of protein contact prediction. As an example, we implemented and tested a BLOSUM62-based pseudo-count strategy in mutual information analysis...
October 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27782608/a-compact-low-cost-marx-bank-for-generating-capillary-discharge-plasmas
#15
A E Dyson, C Thornton, S M Hooker
We describe in detail a low power Compact Marx Bank (CMB) circuit that can provide 20 kV, 500 A pulses of approximately 100-200 ns duration. One application is the generation of capillary discharge plasmas of density ≈10(18) cm(-3) used in laser plasma accelerators. The CMB is triggered with a high speed solid state switch and gives a high voltage output pulse with a ns scale rise time into a 50 Ω load (coaxial cable) with <4 ns voltage jitter. Its small size (10 cm  ×  25 cm  ×  5 cm) means that it can be placed right next to the capillary discharge in the target chamber to avoid the need to impedance match...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27782567/systematic-effects-from-an-ambient-temperature-continuously-rotating-half-wave-plate
#16
T Essinger-Hileman, A Kusaka, J W Appel, S K Choi, K Crowley, S P Ho, N Jarosik, L A Page, L P Parker, S Raghunathan, S M Simon, S T Staggs, K Visnjic
We present an evaluation of systematic effects associated with a continuously rotating, ambient-temperature half-wave plate (HWP) based on two seasons of data from the Atacama B-Mode Search (ABS) experiment located in the Atacama Desert of Chile. The ABS experiment is a microwave telescope sensitive at 145 GHz. Here we present our in-field evaluation of celestial (Cosmic Microwave Background (CMB) plus galactic foreground) temperature-to-polarization leakage. We decompose the leakage into scalar, dipole, and quadrupole leakage terms...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27768373/demonstration-of-cosmic-microwave-background-delensing-using-the-cosmic-infrared-background
#17
Patricia Larsen, Anthony Challinor, Blake D Sherwin, Daisy Mak
Delensing is an increasingly important technique to reverse the gravitational lensing of the cosmic microwave background (CMB) and thus reveal primordial signals the lensing may obscure. We present a first demonstration of delensing on Planck temperature maps using the cosmic infrared background (CIB). Reversing the lensing deflections in Planck CMB temperature maps using a linear combination of the 545 and 857 GHz maps as a lensing tracer, we find that the lensing effects in the temperature power spectrum are reduced in a manner consistent with theoretical expectations...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27754138/os-27-02-cerebral-microbleeds-and-asymptomatic-cerebral-infarctions-in-patients-with-atrial-fibrillation
#18
Tsukasa Saito, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe
OBJECTIVE: Atrial fibrillation (AF) is a cardiac arrhythmia that does not infrequently induce ischemic strokes; however, little research has been reported on focal cerebral microangiopathic lesions in patients with AF. Recently cerebral microbleeds (CMBs) have been noticed for their potential implication in cerebral small vessel dis- ease. Therefore, we had 2 goals in the present study: (1) to compare the prevalence of CMBs in patients with AF with that in patients without AF, and (2) to prove that CMBs could be a clinical predictive factor for the development of future cerebral microangiopathy in patients with AF without a history of symptomatic cerebral infarction in a prospective manner...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754087/os-20-01-a-high-normal-ankle-brachial-index-is-associated-with-arterial-stiffness-and-target-organ-damage-the-okinawa-peripheral-arterial-disease-study-opads
#19
Akio Ishida, Yoshino Kinjo, Yuichiro Toma, Kozen Kinjo, Kunitoshi Iseki, Yusuke Ohya
OBJECTIVE: We reported that ankle-brachial index (ABI) was lowest at <40 years, and increased with age until 60 years and decreased thereafter in a screened cohort of Japanese general population. We hypothesized that this increase in ABI with age occurs owing to increasing arterial stiffness and wave reflection, and therefore, a high normal ABI is associated with target organ damage. DESIGN AND METHOD: We measured ABI and brachial-ankle pulse wave velocity (baPWV) by an automatic oscillometric method...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27745674/identification-and-elucidation-of-anthropogenic-source-contribution-in-pm10-pollutant-insight-gain-from-dispersion-and-receptor-models
#20
Debananda Roy, Gurdeep Singh, Pankaj Yadav
Source apportionment study of PM10 (Particulate Matter) in a critically polluted area of Jharia coalfield, India has been carried out using Dispersion model, Principle Component Analysis (PCA) and Chemical Mass Balance (CMB) techniques. Dispersion model Atmospheric Dispersion Model (AERMOD) was introduced to simplify the complexity of sources in Jharia coalfield. PCA and CMB analysis indicates that monitoring stations near the mining area were mainly affected by the emission from open coal mining and its associated activities such as coal transportation, loading and unloading of coal...
October 2016: Journal of Environmental Sciences (China)
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