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https://www.readbyqxmd.com/read/27905358/-do-cerebral-microbleeds-increase-the-risk-of-hemorrhagic-complications-of-thrombolytic-therapy
#1
T A Polyakova, A V Arablinsky, O S Levin
The role of the cerebral microbleeds (CMB) as a potential predictor of hemorrhagic complications of thrombolytic therapy is discussed. CMB are small perivascular hemosiderin deposits in the brain detected by magnetic resonance imaging in gradient echo T2* or SWI sequences. They are associated (along with leukoaraiosis or lacunes) with cerebral microangiopathies. Most often CMB are associated with hypertensive arteriopathy (the main cause of CMB localization) or cerebral amyloid angiopathy (the main cause of cerebral CMB)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905355/-cerebral-microbleeds-in-cerebrovascular-and-neurodegenerative-diseases-with-cognitive-impairment
#2
T A Polyakova, O S Levin
AIM: To study a role of cerebral microbleeds (CMB) in the diagnosis of main cerebrovascular and neurodegenerative diseases with cognitive impairment. MATERIAL AND METHODS: CMB were studied in 120 patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and vascular dementia using 1.5T MRI in T2 * gradient echo. An impact of CMB on cognitive functions and the relationship with signs of vascular and neurodegenerative lesions of the brain were studied as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27898582/antithrombotic-therapy-in-patients-with-cerebral-microbleeds
#3
Duncan Wilson, David J Werring
PURPOSE OF REVIEW: Cerebral microbleeds (CMBs) are a radiological marker of cerebral small vessel disease corresponding to small haemosiderin foci identified by blood-sensitive MRI. CMBs are common in older community populations, and in individuals with ischaemic stroke or transient ischaemic attack (TIA), and intracerebral haemorrhage (ICH). We summarize how CMBs might contribute to assessing the future risk of ischaemic stroke and ICH to inform antithrombotic (antiplatelet or anticoagulant) decisions...
November 24, 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27884527/source-apportionment-of-size-fractionated-particles-during-the-2013-asian-youth-games-and-the-2014-youth-olympic-games-in-nanjing-china
#4
Pulong Chen, Tijian Wang, Xiaobo Lu, Yiyong Yu, Matthew Kasoar, Min Xie, Bingliang Zhuang
In this study, samples of size-fractionated particulate matter were collected continuously using a 9-size interval cascade impactor at an urban site in Nanjing, before, during and after the Asian Youth Games (AYG), from July to September of 2013, and the Youth Olympic Games (YOG), from July to September of 2014. First, elemental concentrations, water-soluble ions including Cl(-), NO3(-), SO4(2-), NH4(+), K(+), Na(+) and Ca(2+), organic carbon (OC) and elemental carbon (EC) were analysed. Then, the source apportionment of the fine and coarse particulate matter was carried out using the chemical mass balance (CMB) model...
November 21, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27807676/pm2-5-pollution-from-household-solid-fuel-burning-practices-in-central-india-2-application-of-receptor-models-for-source-apportionment
#5
Jeevan Lal Matawle, Shamsh Pervez, Manas Kanti Deb, Anjali Shrivastava, Suresh Tiwari
USEPA's UNMIX, positive matrix factorization (PMF) and effective variance-chemical mass balance (EV-CMB) receptor models were applied to chemically speciated profiles of 125 indoor PM2.5 measurements, sampled longitudinally during 2012-2013 in low-income group households of Central India which uses solid fuels for cooking practices. Three step source apportionment studies were carried out to generate more confident source characterization. Firstly, UNMIX6.0 extracted initial number of source factors, which were used to execute PMF5...
November 2, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27797756/mitos-jl-mutual-information-tools-for-protein-sequence-analysis-in-the-julia-language
#6
Diego J Zea, Diego Anfossi, Morten Nielsen, Cristina Marino-Buslje
MOTIVATION: MIToS is an environment for mutual information analysis and a framework for protein multiple sequence alignments (MSAs) and protein structures (PDB) management in Julia language. It integrates sequence and structural information through SIFTS, making Pfam MSAs analysis straightforward. MIToS streamlines the implementation of any measure calculated from residue contingency tables and its optimization and testing in terms of protein contact prediction. As an example, we implemented and tested a BLOSUM62-based pseudo-count strategy in mutual information analysis...
October 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27782608/a-compact-low-cost-marx-bank-for-generating-capillary-discharge-plasmas
#7
A E Dyson, C Thornton, S M Hooker
We describe in detail a low power Compact Marx Bank (CMB) circuit that can provide 20 kV, 500 A pulses of approximately 100-200 ns duration. One application is the generation of capillary discharge plasmas of density ≈10(18) cm(-3) used in laser plasma accelerators. The CMB is triggered with a high speed solid state switch and gives a high voltage output pulse with a ns scale rise time into a 50 Ω load (coaxial cable) with <4 ns voltage jitter. Its small size (10 cm  ×  25 cm  ×  5 cm) means that it can be placed right next to the capillary discharge in the target chamber to avoid the need to impedance match...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27782567/systematic-effects-from-an-ambient-temperature-continuously-rotating-half-wave-plate
#8
T Essinger-Hileman, A Kusaka, J W Appel, S K Choi, K Crowley, S P Ho, N Jarosik, L A Page, L P Parker, S Raghunathan, S M Simon, S T Staggs, K Visnjic
We present an evaluation of systematic effects associated with a continuously rotating, ambient-temperature half-wave plate (HWP) based on two seasons of data from the Atacama B-Mode Search (ABS) experiment located in the Atacama Desert of Chile. The ABS experiment is a microwave telescope sensitive at 145 GHz. Here we present our in-field evaluation of celestial (Cosmic Microwave Background (CMB) plus galactic foreground) temperature-to-polarization leakage. We decompose the leakage into scalar, dipole, and quadrupole leakage terms...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27768373/demonstration-of-cosmic-microwave-background-delensing-using-the-cosmic-infrared-background
#9
Patricia Larsen, Anthony Challinor, Blake D Sherwin, Daisy Mak
Delensing is an increasingly important technique to reverse the gravitational lensing of the cosmic microwave background (CMB) and thus reveal primordial signals the lensing may obscure. We present a first demonstration of delensing on Planck temperature maps using the cosmic infrared background (CIB). Reversing the lensing deflections in Planck CMB temperature maps using a linear combination of the 545 and 857 GHz maps as a lensing tracer, we find that the lensing effects in the temperature power spectrum are reduced in a manner consistent with theoretical expectations...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27754138/os-27-02-cerebral-microbleeds-and-asymptomatic-cerebral-infarctions-in-patients-with-atrial-fibrillation
#10
Tsukasa Saito, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe
OBJECTIVE: Atrial fibrillation (AF) is a cardiac arrhythmia that does not infrequently induce ischemic strokes; however, little research has been reported on focal cerebral microangiopathic lesions in patients with AF. Recently cerebral microbleeds (CMBs) have been noticed for their potential implication in cerebral small vessel dis- ease. Therefore, we had 2 goals in the present study: (1) to compare the prevalence of CMBs in patients with AF with that in patients without AF, and (2) to prove that CMBs could be a clinical predictive factor for the development of future cerebral microangiopathy in patients with AF without a history of symptomatic cerebral infarction in a prospective manner...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754087/os-20-01-a-high-normal-ankle-brachial-index-is-associated-with-arterial-stiffness-and-target-organ-damage-the-okinawa-peripheral-arterial-disease-study-opads
#11
Akio Ishida, Yoshino Kinjo, Yuichiro Toma, Kozen Kinjo, Kunitoshi Iseki, Yusuke Ohya
OBJECTIVE: We reported that ankle-brachial index (ABI) was lowest at <40 years, and increased with age until 60 years and decreased thereafter in a screened cohort of Japanese general population. We hypothesized that this increase in ABI with age occurs owing to increasing arterial stiffness and wave reflection, and therefore, a high normal ABI is associated with target organ damage. DESIGN AND METHOD: We measured ABI and brachial-ankle pulse wave velocity (baPWV) by an automatic oscillometric method...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27745674/identification-and-elucidation-of-anthropogenic-source-contribution-in-pm10-pollutant-insight-gain-from-dispersion-and-receptor-models
#12
Debananda Roy, Gurdeep Singh, Pankaj Yadav
Source apportionment study of PM10 (Particulate Matter) in a critically polluted area of Jharia coalfield, India has been carried out using Dispersion model, Principle Component Analysis (PCA) and Chemical Mass Balance (CMB) techniques. Dispersion model Atmospheric Dispersion Model (AERMOD) was introduced to simplify the complexity of sources in Jharia coalfield. PCA and CMB analysis indicates that monitoring stations near the mining area were mainly affected by the emission from open coal mining and its associated activities such as coal transportation, loading and unloading of coal...
October 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27734280/direct-cloning-and-transplanting-of-large-dna-fragments-from-escherichia-coli-chromosome
#13
Ying Zhu, Yan Yang, Pingping Den, Yong Huang, Mengxiang Ni, Hongqing Fang
We applied a resistance split-fusion strategy to increase the in vivo direct cloning efficiency mediated by Red recombination. The cat cassette was divided into two parts: cma (which has a homologous sequence with cmb) and cmb, each of which has no resistance separately unless the two parts are fused together. The cmb sequence was integrated into one flank of a target cloning region in the chromosome, and a linear vector containing the cma sequence was electroporated into the cells to directly capture the target region...
October 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27733027/difference-in-the-location-and-risk-factors-of-cerebral-microbleeds-according-to-ischemic-stroke-subtypes
#14
Bum Joon Kim, Youngshin Yoon, Hoyon Sohn, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: The location of cerebral microbleeds (CMBs) may differ according to ischemic stroke subtype, and the underlying pathomechanism may differ by their location. Here, we investigated the characteristics of CMBs according to various ischemic stroke subtypes to verify this issue. METHODS: Patients with acute ischemic stroke were consecutively included. The presence of CMBs was determined by gradient echo image sequence. The distribution of CMBs was classified as deep, lobar, or diffuse (both deep and lobar)...
September 2016: Journal of Stroke
https://www.readbyqxmd.com/read/27723709/-do-cerebral-microbleeds-increase-the-risk-of-hemorrhagic-complications-of-thrombolytic-therapy
#15
T A Polyakova, A V Arablinsky, O S Levin
The role of the cerebral microbleeds (CMB) as a potential predictor of hemorrhagic complications of thrombolytic therapy is discussed. CMB are small perivascular hemosiderin deposits in the brain detected by magnetic resonance imaging in gradient echo T2* or SWI sequences. They are associated (along with leukoaraiosis or lacunes) with cerebral microangiopathies. Most often CMB are associated with hypertensive arteriopathy (the main cause of CMB localization) or cerebral amyloid angiopathy (the main cause of cerebral CMB)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27723706/-cerebral-microbleeds-in-cerebrovascular-and-neurodegenerative-diseases-with-cognitive-impairment
#16
T A Polyakova, O S Levin
AIM: To study a role of cerebral microbleeds (CMB) in the diagnosis of main cerebrovascular and neurodegenerative diseases with cognitive impairment. MATERIAL AND METHODS: CMB were studied in 120 patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and vascular dementia using 1.5T MRI in T2 * gradient echo. An impact of CMB on cognitive functions and the relationship with signs of vascular and neurodegenerative lesions of the brain were studied as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27643065/os-27-02-cerebral-microbleeds-and-asymptomatic-cerebral-infarctions-in-patients-with-atrial-fibrillation
#17
Tsukasa Saito, Yuichiro Kawamura, Nobuyuki Sato, Naoyuki Hasebe
OBJECTIVE: Atrial fibrillation (AF) is a cardiac arrhythmia that does not infrequently induce ischemic strokes; however, little research has been reported on focal cerebral microangiopathic lesions in patients with AF. Recently cerebral microbleeds (CMBs) have been noticed for their potential implication in cerebral small vessel dis- ease. Therefore, we had 2 goals in the present study: (1) to compare the prevalence of CMBs in patients with AF with that in patients without AF, and (2) to prove that CMBs could be a clinical predictive factor for the development of future cerebral microangiopathy in patients with AF without a history of symptomatic cerebral infarction in a prospective manner...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643012/os-20-01-a-high-normal-ankle-brachial-index-is-associated-with-arterial-stiffness-and-target-organ-damage-the-okinawa-peripheral-arterial-disease-study-opads
#18
Akio Ishida, Yoshino Kinjo, Yuichiro Toma, Kozen Kinjo, Kunitoshi Iseki, Yusuke Ohya
OBJECTIVE: We reported that ankle-brachial index (ABI) was lowest at <40 years, and increased with age until 60 years and decreased thereafter in a screened cohort of Japanese general population. We hypothesized that this increase in ABI with age occurs owing to increasing arterial stiffness and wave reflection, and therefore, a high normal ABI is associated with target organ damage. DESIGN AND METHOD: We measured ABI and brachial-ankle pulse wave velocity (baPWV) by an automatic oscillometric method...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638784/cerebral-microbleeds-vascular-risk-factors-and-magnetic-resonance-imaging-markers-the-northern-manhattan-study
#19
Michelle R Caunca, Victor Del Brutto, Hannah Gardener, Nirav Shah, Nelly Dequatre-Ponchelle, Ying Kuen Cheung, Mitchell S V Elkind, Truman R Brown, Charlotte Cordonnier, Ralph L Sacco, Clinton B Wright
BACKGROUND: Cerebral microbleeds (CMBs) represent intracerebral hemorrhages due to amyloid angiopathy or exposure to modifiable risk factors. Few community-based stroke-free studies including blacks and Hispanics have been done. METHODS AND RESULTS: The Northern Manhattan Study (NOMAS) is a stroke-free, racially and ethnically diverse cohort study. Brain MRI was performed in 1290 participants, 925 of whom had available T2* gradient-recall echo data. We used multivariable logistic regression to examine the association of sociodemographics, vascular risk factors, apolipoprotein E (APOE) genotype, and brain MRI markers with CMB presence and location...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27629091/synergistic-effects-of-longitudinal-amyloid-and-vascular-changes-on-lobar-microbleeds
#20
Yeo Jin Kim, Hee Jin Kim, Jae-Hyun Park, Seonwoo Kim, Sook-Young Woo, Ki-Chang Kwak, Jong Min Lee, Na-Yeon Jung, Jae Seung Kim, Yearn Seong Choe, Kyung-Han Lee, Seung Hwan Moon, Jae-Hong Lee, Yun Joong Kim, David J Werring, Duk L Na, Sang Won Seo
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI). METHODS: Among 72 patients with svMCI who underwent brain MRI and [(11)C] Pittsburgh compound B (PiB)-PET, 52 (72.2%) completed the third year of follow-up. These patients were evaluated by annual neuropsychological testing, brain MRI, and follow-up PiB-PET...
October 11, 2016: Neurology
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