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https://www.readbyqxmd.com/read/28640874/risk-factors-are-different-for-deep-and-lobar-remote-hemorrhages-after-intravenous-thrombolysis
#1
Luis Prats-Sanchez, Alejandro Martínez-Domeño, Pol Camps-Renom, Raquel Delgado-Mederos, Daniel Guisado-Alonso, Rebeca Marín, Laura Dorado, Salvatore Rudilosso, Alejandra Gómez-González, Francisco Purroy, Manuel Gómez-Choco, David Cánovas, Dolores Cocho, Moises Garces, Sonia Abilleira, Joan Martí-Fàbregas
BACKGROUND AND PURPOSE: Remote parenchymal haemorrhage (rPH) after intravenous thrombolysis is defined as hemorrhages that appear in brain regions without visible ischemic damage, remote from the area of ischemia causing the initial stroke symptom. The pathophysiology of rPH is not clear and may be explained by different underlying mechanisms. We hypothesized that rPH may have different risk factors according to the bleeding location. We report the variables that we found associated with deep and lobar rPH after intravenous thrombolysis...
2017: PloS One
https://www.readbyqxmd.com/read/28621995/two-and-three-dimensional-probes-of-parity-in-primordial-gravity-waves
#2
Kiyoshi Wesley Masui, Ue-Li Pen, Neil Turok
We show that three-dimensional information is critical to discerning the effects of parity violation in the primordial gravity-wave background. If present, helical gravity waves induce parity-violating correlations in the cosmic microwave background (CMB) between parity-odd polarization B modes and parity-even temperature anisotropies (T) or polarization E modes. Unfortunately, EB correlations are much weaker than would be naively expected, which we show is due to an approximate symmetry resulting from the two-dimensional nature of the CMB...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28587615/genome-wide-scans-for-the-identification-of-plasmodium-vivax-genes-under-positive-selection
#3
Hai-Mo Shen, Shen-Bo Chen, Yue Wang, Bin Xu, Eniola Michael Abe, Jun-Hu Chen
BACKGROUND: The current trend of Plasmodium vivax cases imported from Southeast Asia into China has sharply increased recently, especially from the China-Myanmar border (CMB) area. High recombination rates of P. vivax populations associated with varied transmission intensity might cause distinct local selective pressures. The information on the genetic variability of P. vivax in this area is scant. Hence, this study assessed the genetic diversity of P. vivax genome sequence in CMB area and aimed to provide information on the positive selection of new gene loci...
June 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28583195/effects-of-phosphodiesterase-3a-modulation-on-murine-cerebral-microhemorrhages
#4
Rachita K Sumbria, Vitaly Vasilevko, Mher Mahoney Grigoryan, Annlia Paganini-Hill, Ronald Kim, David H Cribbs, Mark J Fisher
BACKGROUND: Cerebral microbleeds (CMB) are MRI-demonstrable cerebral microhemorrhages (CMH) which commonly coexist with ischemic stroke. This creates a challenging therapeutic milieu, and a strategy that simultaneously protects the vessel wall and provides anti-thrombotic activity is an attractive potential approach. Phosphodiesterase 3A (PDE3A) inhibition is known to provide cerebral vessel wall protection combined with anti-thrombotic effects. As an initial step in the development of a therapy that simultaneously treats CMB and ischemic stroke, we hypothesized that inhibition of the PDE3A pathway is protective against CMH development...
June 5, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28566143/intracerebral-haemorrhage-risk-in-microbleed-positive-ischaemic-stroke-patients-with-atrial-fibrillation-preliminary-meta-analysis-of-cohorts-and-anticoagulation-decision-schema
#5
Andreas Charidimou, Gregoire Boulouis, Sara Shams, David Calvet, Ashkan Shoamanesh
INTRODUCTION: Whether ischaemic stroke patients with atrial fibrillation (AF) and cerebral microbleeds (CMBs) on MRI can be safely anticoagulated is a hotly debated topic. We performed a systematic review and meta-analysis of published aggregate data, to investigate the risk of subsequent intracerebral haemorrhage (ICH) based on CMBs presence in this stroke population, generally considered for oral anticoagulation. We also suggest a decision-making schema for anticoagulation use in this setting...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28565841/ultrasound-combined-with-targeted-cationic-microbubble-mediated-angiogenesis-gene-transfection-improves-ischemic-heart-function
#6
Qing Zhou, Qing Deng, Bo Hu, Yi-Jia Wang, Jin-Ling Chen, Jing-Jing Cui, Sheng Cao, Hong-Ning Song
The present study aimed to construct targeted cationic microbubbles (TCMBs) by synthesizing cationic microbubbles conjugated to an intercellular adhesion molecule-1 (ICAM-1) antibody, and then to use the TCMBs to deliver the angiopoietin-1 (Ang-1) gene into infarcted heart tissue using ultrasound-mediated microbubble destruction. It was hypothesized that the TCMBs would accumulate in higher numbers than non-targeted cationic microbubbles (CMBs) in the infarcted heart, and would therefore increase the efficiency of targeted Ang-1 gene transfection and promote angiogenesis...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560152/improved-cerebral-microbleeds-detection-using-their-magnetic-signature-on-t2-phase-contrast-a-comparison-study-in-a-clinical-setting
#7
Takoua Kaaouana, Anne Bertrand, Fatma Ouamer, Bruno Law-Ye, Nadya Pyatigorskaya, Ali Bouyahia, Nathalie Thiery, Carole Dufouil, Christine Delmaire, Didier Dormont, Ludovic de Rochefort, Marie Chupin
INTRODUCTION/PURPOSE: In vivo detection of cerebral microbleeds (CMBs) from T2* gradient recalled echo (GRE) magnitude image suffers from low specificity, modest inter-rater reproducibility and is biased by its sensitivity to acquisition parameters. New methods were proposed for improving this identification, but they mostly rely on 3D acquisitions, not always feasible in clinical practice. A fast 2D phase processing technique for computing internal field maps (IFM) has been shown to make it possible to characterize CMBs through their magnetic signature in routine clinical setting, based on 2D multi-slice acquisitions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28556471/putative-cerebral-microbleeds-in-dogs-undergoing-magnetic-resonance-imaging-of-the-head-a-retrospective-study-of-demographics-clinical-associations-and-relationship-to-case-outcome
#8
S C Kerwin, J M Levine, C M Budke, J F Griffin, C E Boudreau
BACKGROUND: Cerebral microbleeds (CMBs) are focal intraparenchymal signal voids on gradient-echo magnetic resonance imaging (MRI), corresponding to regions of chronic hemorrhage. In humans, they are associated with systemic disease and shorter survival times. Although similar findings have been identified in dogs, their epidemiology and clinical correlations have not been investigated. OBJECTIVE: To determine epidemiological features, clinical associations, and associations with outcome for putative CMB-like foci (putative microbleeds [pMBs]) identified by T2*-weighted MRI in dogs...
May 27, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28555646/geomagnetic-spikes-on-the-core-mantle-boundary
#9
Christopher Davies, Catherine Constable
Extreme variations of Earth's magnetic field occurred in the Levant region around 1000 BC, when the field intensity rapidly rose and fell by a factor of 2. No coherent link currently exists between this intensity spike and the global field produced by the core geodynamo. Here we show that the Levantine spike must span >60° longitude at Earth's surface if it originates from the core-mantle boundary (CMB). Several low intensity data are incompatible with this geometric bound, though age uncertainties suggest these data could have sampled the field before the spike emerged...
May 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28555127/cerebral-microbleeds-hypertension-and-intracerebral-hemorrhage-in-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#10
Jung Seok Lee, KeunHyuk Ko, Jung-Hwan Oh, Joon Hyuk Park, Ho Kyu Lee, David Floriolli, Annlia Paganini-Hill, Mark Fisher
BACKGROUND: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common genetic cause of stroke. In addition to ischemic stroke, CADASIL predisposes to development of cerebral microbleeds (CMB). CMB and hypertension are known to be associated with intracerebral hemorrhage (ICH). The purpose of this study was to analyze the relationships among CMB, hypertension, and ICH in CADASIL. MATERIALS AND METHODS: We enrolled 94 genetically confirmed CADASIL patients from 76 unrelated families at Jeju National University Hospital (Korea) between March 2012 and February 2015...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28500352/whole-mantle-convection-with-tectonic-plates-preserves-long-term-global-patterns-of-upper-mantle-geochemistry
#11
T L Barry, J H Davies, M Wolstencroft, I L Millar, Z Zhao, P Jian, I Safonova, M Price
The evolution of the planetary interior during plate tectonics is controlled by slow convection within the mantle. Global-scale geochemical differences across the upper mantle are known, but how they are preserved during convection has not been adequately explained. We demonstrate that the geographic patterns of chemical variations around the Earth's mantle endure as a direct result of whole-mantle convection within largely isolated cells defined by subducting plates. New 3D spherical numerical models embedded with the latest geological paleo-tectonic reconstructions and ground-truthed with new Hf-Nd isotope data, suggest that uppermost mantle at one location (e...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28479795/prevalence-of-cerebral-microbleeds-in-thai-patients-with-ischemic-stroke
#12
Artit Potigumjon, Arvemas Watcharakorn, Pornpatr A Dharmasaroja
BACKGROUND: With the widespread use of magnetic resonance imaging (MRI), cerebral microbleeds (CMBs) are commonly detected. Ethnicity seems to play a role in the prevalence of CMB, with higher prevalence in participants from Asian origin. The purpose of the study is to look for the prevalence of CMBs and associated factors in Thai patients with ischemic stroke. METHODS: Patients with acute ischemic stroke who had MRI and magnetic resonance angiography during January-August 2014 were included in the study...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28476760/distribution-of-lacunes-in-cerebral-amyloid-angiopathy-and-hypertensive-small-vessel-disease
#13
Marco Pasi, Gregoire Boulouis, Panagiotis Fotiadis, Eitan Auriel, Andreas Charidimou, Kellen Haley, Alison Ayres, Kristin M Schwab, Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Leonardo Pantoni, Steven M Greenberg, M Edip Gurol
OBJECTIVE: To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS: We defined lobar and deep lacunes similar to the topographic distribution used for ICH and cerebral microbleeds (CMBs). We then compared their distribution between patients with CAA-ICH and those with strictly deep CMB and ICH (HTN-ICH)...
June 6, 2017: Neurology
https://www.readbyqxmd.com/read/28408200/angiogenesis-targeting-microbubbles-combined-with-ultrasound-mediated-gene-therapy-in-brain-tumors
#14
En-Ling Chang, Chien-Yu Ting, Po-Hong Hsu, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, Yuan-Chih Chang, Hong-Lin Chan, Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan, Chih-Kuang Yeh
The major challenges in gene therapy for brain cancer are poor transgene expression due to the blood-brain barrier (BBB) and neurologic damage caused by conventional intracerebral injection. Non-viral gene delivery using ultrasound-targeted microbubbles (MBs) oscillation via the systematic transvascular route is attractive, but there is currently no high-yielding and targeted gene expression method. In this study, we developed a non-viral and angiogenesis-targeting gene delivery approach for efficient brain tumor gene therapy without brain damage...
April 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28399464/surface-initiated-supplemental-activator-and-reducing-agent-atom-transfer-radical-polymerization-si-sara-atrp-of-4-vinylpyridine-on-poly-ethylene-terephthalate
#15
Mohamad Maaz, Tamara Elzein, Alice Bejjani, Nadine Barroca-Aubry, Bénédicte Lepoittevin, Diana Dragoe, Sandra Mazerat, Bilal Nsouli, Philippe Roger
Poly(ethylene terephthalate) (PET) substrates were modified by means of surface-initiated supplemental activator and reducing agent atom transfer radical polymerization (SI-SARA-ATRP) of 4-vinylpyridine (4VP). Substrates were pretreated in order to graft chloromethylbenzene (CMB) units capable of initiating the radical polymerization reaction of 4VP units. Surface characterization techniques, including Water Contact Angle (WCA), Attenuated Total Reflection (ATR), X-ray photoelectron spectroscopy (XPS), Atomic Force Microscopy (AFM) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) showed a successful grafting of a stable, smooth and homogenous layer of p4VP...
April 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28383912/chaunopyran-a-co-cultivation-of-marine-mollusk-derived-fungi-activates-a-rare-class-of-2-alkenyl-tetrahydropyran
#16
Zhuo Shang, Angela A Salim, Robert J Capon
Co-cultivation of Chaunopycnis sp. (CMB-MF028) and Trichoderma hamatum (CMB-MF030), fungal strains co-isolated from the inner tissue of an intertidal rock platform mollusc (Siphonaria sp), resulted in transcriptional activation of a rare class of 2-alkenyl-tetrahydropyran, chaunopyran A (7), and biotransformation and deactivation of the antifungal pyridoxatin (1), to methyl-pyridoxatin (8). This study illustrates the complexity of offensive and counter-offensive molecular defenses encountered during fungal co-cultivation, and the opportunities for activating new, otherwise transcriptionally silent secondary metabolites...
April 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28383269/talarolide-a-a-cyclic-heptapeptide-hydroxamate-from-an-australian-marine-tunicate-associated-fungus-talaromyces-sp-cmb-tu011
#17
Pradeep Dewapriya, Pritesh Prasad, Rakesh Damodar, Angela A Salim, Robert J Capon
A miniaturized 24-well plate microbioreactor approach was used to explore secondary metabolite media dependence in an Australian marine tunicate-associated fungus, Talaromyces sp. (CMB TU011). Detailed chemical investigations of an antifungal M1-saline cultivation yielded talarolide A (1), only the second reported natural cyclic peptide hydroxamate, and the first from a fungus. The antifungal properties of the M1-saline extract were attributed to the known diterpene glycoside sordarin (2). Structure elucidation of 1 and 2 was achieved by detailed spectroscopic analysis, with amino acid configurations in 1 assigned by the C3 and C18 Marfey's methods, and l-Ala and d-Ala regiochemistry by the recently reported 2D C3 Marfey's method...
April 6, 2017: Organic Letters
https://www.readbyqxmd.com/read/28364107/-advantage-of-extralevator-abdominoperineal-excision-comparing-to-the-conventional-abdominoperineal-excision-for-low-rectal-cancer-a-meta-analysis
#18
Qi Wang, Chengwen Xu, Jiajia Wang, Quan Ren, Jiaqing Cao
Whether extralevator abdominoperineal excision (ELAPE) improves survival and safety remains controversial. Systematic review of all comparative studies to define the superiority of ELAPE to conventional abdominoperineal excision (APE).
 Methods: Corresponding data, with case-control studies or cohorts regarding intraoperative perforation rate, the local recurrence rate and postoperative complications in the ELAPE group and the APE group, were retrieved from PubMed, Embase, the Cochrane Library, Chinese Biomedical Literature (CMB), VIP, China National Knowledge Infrastructure (CNKI), and Wanfang Database...
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28347929/cerebral-microbleeds-and-risk-of-incident-dementia-the-framingham-heart-study
#19
José R Romero, Alexa Beiser, Jayandra J Himali, Ashkan Shoamanesh, Charles DeCarli, Sudha Seshadri
Cerebral microbleeds (CMBs) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia: hypertensive and cerebral amyloid angiopathy. CMB detection in asymptomatic persons may help identify those at risk for dementia and may influence preventive strategies and design of clinical trials testing treatments for dementia. We studied the association of CMB with risk of incident dementia in community dwelling individuals. A total of 1296 dementia-free Framingham Heart Study participants (mean age 72 years; 54% women) with available brain MRI and incident dementia data during a mean follow-up period of 6...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28330241/purification-characterization-gene-cloning-and-expression-of-gh-10-xylanase-penicillium-citrinum-isolate-hzn13
#20
Zabin K Bagewadi, Sikandar I Mulla, Harichandra Z Ninnekar
An extracellular thermostable xylanase (Xyl-IIb) produced by Penicillium citrinum isolate HZN13 was purified to homogeneity using DEAE-Sepharose, Sephadex G-100 and Bio-Gel P-60 chromatography with specific activity of 6272.7 U/mg and 19.6-fold purification. The purification revealed the occurrence of multiple forms of xylanases (Xyl-I, Xyl-IIa, Xyl-IIb and Xyl-III). The molecular mass of highly purified Xyl-IIb was ~31 kDa with SDS-PAGE. The enzyme was cellulase-free, thermostable (55-75 °C) and acidophilic (3...
December 2016: 3 Biotech
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