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Yuan-Hsiung Tsai, Meng Lee, Leng-Chieh Lin, Sheng-Wei Chang, Hsu-Huei Weng, Jen-Tsung Yang, Yen-Chu Huang, Ming-Hsueh Lee
Background: Chronic kidney disease (CKD) has been closely associated with hypertension and stroke. Although studies have reported the relationship between CKD and cerebral small vessel disease (SVD), the link between CKD, hypertension, and SVD is uncertain. The aim of this study was to investigate the association between CKD and SVD in patients with strictly hypertensive intracerebral hemorrhage (ICH). Methods: 142 patients with acute hypertensive ICH were enrolled in this study...
2018: Frontiers in Neurology
Inmaculada Boyano, Ana Ramos, Jorge López-Alvarez, Carolina Mendoza-Rebolledo, Emma Osa-Ruiz, Irene Rodríguez, Almudena Pérez, Eva Alfayate, Belén González, Laura Fernández, Luis Agüera-Ortiz, Alberto Rábano, Javier Olazarán
OBJECTIVE: We conducted a longitudinal study to explore the clinical and pathological correlates of cerebral microbleeds (CMBs) in institutionalized patients with dementia. METHODS: Clinical and magnetic resonance imaging (MRI) data were extracted from 182 nursing home patients (mean age [standard deviation]: 81.3 [6.9], 78.0% female, and 83.4% moderate to severe dementia), which were divided according to the CMBs number and location. One-year follow-up data were obtained from 153 patients, and postmortem pathological diagnosis was available in 40 patients...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
Ibrahim M Al-Naiema, Subin Yoon, Yu-Qin Wang, Yuan-Xun Zhang, Rebecca J Sheesley, Elizabeth A Stone
Chemical mass balance (CMB) modeling and radiocarbon measurements were combined to evaluate the sources of carbonaceous fine particulate matter (PM2.5 ) in Shenzhen, China during and after the 2011 summer Universiade games when air pollution control measurements were implemented to achieve air quality targets. Ambient PM2.5 filter samples were collected daily at two sampling sites (Peking University Shenzhen campus and Longgang) over 24 consecutive days, covering the controlled and uncontrolled periods. During the controlled period, the average PM2...
May 2, 2018: Environmental Pollution
L-W Antony Chen, Jun-Ji Cao
A Hybrid Environmental Receptor Model (HERM) that unifies the theory of effective-variance chemical mass balance (EV-CMB) and positive matrix factorization (PMF) models was developed to support the weight-of-evidence (WOE) approach of air pollution source apportionment. The HERM software is capable of 1) conducting EV-CMB analysis for multiple samples in a single iteration; 2) calculating EV-CMB and PMF source contributions as well as middle grounds (hybrid mode) between the two using partial source information available for the study region; 3) reporting source contribution uncertainties and sample-/species-specific fitting performance measures; 4) interfacing with MS Excel® for convenient data inputs/outputs and analysis...
May 3, 2018: Environmental Science & Technology
Nadia Asghar, Shamim Akhtar, Sabahat Naeem, Ahsaan Ahmed, Shaheena Faizy, Muhammad Arif, Zafar Saeed Saify
Six novel analogues were prepared by reacting benzimidazole molecules (BM and CMB) propiophenone and benzoyl chlorides respectively. The structures of newly synthesized compounds were determined with the help of spectroscopic techniques. The compounds were subjected to in-vitro screening for their activity against nematodes. It was observed that the benzimidazole (BM) derivatives possessed more nematicidal activity as compared to that of cyanomethyl-benzimidazole (CMB) for Meloidogyne incognita. Among them, the propiophenone substituted benzimidazole derivative B3 was found to be the most active compound and can be further studied as lead molecule for development of anthelmintic drugs...
May 2018: Pakistan Journal of Pharmaceutical Sciences
Ashkan Shoamanesh, Andrea Morotti, Javier M Romero, Jamary Oliveira-Filho, Frieder Schlunk, Michael J Jessel, Alison M Ayres, Anastasia Vashkevich, Kristin Schwab, Mohammad R Afzal, Christy Cassarly, Renee H Martin, Adnan I Qureshi, Steven M Greenberg, Jonathan Rosand, Joshua N Goldstein
Importance: Response to intensive blood pressure (BP) lowering in acute intracerebral hemorrhage (ICH) might vary with the degree of underlying cerebral small vessel disease. Objectives: To characterize cerebral microbleeds (CMBs) in acute ICH and to assess the potential for interaction between underlying small vessel disease (as indicated by CMB number and location) and assignment to acute intensive BP targeting for functional outcomes and hematoma expansion. Design, Setting, and Participants: Preplanned subgroup analyses in the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH-2) trial were performed...
April 16, 2018: JAMA Neurology
Jingyang Fu, Guangyun Li, Li Wang
Different from GPS, GLONASS, GALILEO and BeiDou-3, it is confirmed that the code multipath bias (CMB), which originate from the satellite end and can be over 1 m, are commonly found in the code observations of BeiDou-2 (BDS) IGSO and MEO satellites. In order to mitigate their adverse effects on absolute precise applications which use the code measurements, we propose in this paper an improved correction model to estimate the CMB. Different from the traditional model which considering the correction values are orbit-type dependent (estimating two sets of values for IGSO and MEO, respectively) and modeling the CMB as a piecewise linear function with a elevation node separation of 10°, we estimate the corrections for each BDS IGSO + MEO satellite on one hand, and a denser elevation node separation of 5° is used to model the CMB variations on the other hand...
April 27, 2018: Sensors
Fu Zhao, Jing Zhang, Peng Li, Qiangyi Zhou, Shun Zhang, Chi Zhao, Bo Wang, Zhijun Yang, Chunde Li, Pinan Liu
INTRODUCTION: Medulloblastoma (MB) is a rare primary brain tumor in adults. We previously evaluated that combining both clinical and molecular classification could improve current risk stratification for adult MB. In this study, we aimed to identify the prognostic value of Ki-67 index in adult MB. METHOD: Ki-67 index of 51 primary adult MBs was reassessed using a computer-based image analysis (Image-Pro Plus). All patients were followed up ranging from 12 months up to 15 years...
April 23, 2018: Journal of Neuro-oncology
Anke M Klein, Elske Salemink, Eva de Hullu, Esther Houtkamp, Marlissa Papa, Mariët van der Molen
The goal of this study was to examine the effects of Cognitive Bias Modification training for Interpretation (CBM-I) in socially anxious adolescents with Mild Intellectual Disabilities (MID). A total of 69 socially anxious adolescents with MID were randomly assigned to either a positive or a neutral control-CMB-I-training. Training included five sessions in a 3-week period, and each session consisted of 40 training items. Adolescents in the positive training group showed a significant reduction in negative interpretation bias on the two interpretation bias tasks after training compared to adolescents in the control-training group...
April 21, 2018: Journal of Autism and Developmental Disorders
Pranamika Bhuyan, Pratibha Deka, Amit Prakash, S Balachandran, Raza Rafiqul Hoque
Aerosol samples (as PM10, n = 250) were collected from three rural/remote receptor locations in the mid Brahmaputra plain region and were chemically characterized for metals (Al, Fe, Co, Cu, Cr, Cd, Mn, Ni, Pb), ions (Ca2+ , Mg2+ , Na+ , K+ , NH4 + , F- , Cl- , NO3 - , SO4 2- ), and carbon. Vital ratios like NO3 - /SO4 2- , EC/OC, K+ /EC, K+ /OC, enrichment factors and inter-species correlations were exploited to appreciate possible sources of aerosol. These empirical analyses pointed towards anthropogenic contributions of aerosol, particularly from biomass burning, vehicular emission, and road dust...
March 2018: Environmental Pollution
J C Purrucker, M Wolf, K Haas, T Siedler, T Rizos, S Khan, P U Heuschmann, R Veltkamp
OBJECTIVES: To identify differences in clinical characteristics and severity of cerebral small vessel disease (CSVD) including cerebral microbleeds (CMBs), between patients suffering ischemic stroke (IS) or intracerebral hemorrhage (ICH) while taking novel (non-vitamin K antagonists) oral anticoagulants (NOACs). METHODS: Multicenter, prospective, observational cohort study performed at 38 centers between 2012 and 2015. We compared demographics, comorbidity, and functional status (before and after stroke) between NOAC-IS and NOAC-ICH patients...
April 16, 2018: Acta Neurologica Scandinavica
Yanhong Zhu, Lin Huang, Jingyi Li, Qi Ying, Hongliang Zhang, Xingang Liu, Hong Liao, Nan Li, Zhenxin Liu, Yuhao Mao, Hao Fang, Jianlin Hu
Particulate matter (PM) in the atmosphere has adverse effects on human health, ecosystems, and visibility. It also plays an important role in meteorology and climate change. A good understanding of its sources is essential for effective emission controls to reduce PM and to protect public health. In this study, a total of 239 PM source apportionment studies in China published during 1987-2017 were reviewed. The documents studied include peer-reviewed papers in international and Chinese journals, as well as degree dissertations...
April 10, 2018: Environment International
Mohammad Arhami, Maryam Zare Shahne, Vahid Hosseini, Navid Roufigar Haghighat, Alexandra M Lai, James J Schauer
Currently PM2.5 is a major air pollution concern in Tehran, Iran due to frequent high levels and possible adverse impacts. In this study, which is the first of its kind to take place in Tehran, composition and sources of PM2.5 and carbonaceous aerosol were determined, and their seasonal trends were studied. In this regard, fine PM samples were collected every six days at a residential station for one year and the chemical constituents including organic marker species, metals, and ions were analyzed by chemical analysis...
April 9, 2018: Environmental Pollution
Andy J Daly-Smith, Stephen Zwolinsky, Jim McKenna, Phillip D Tomporowski, Margaret Anne Defeyter, Andrew Manley
Objective: To examine the impact of acute classroom movement break (CMB) and physically active learning (PAL) interventions on physical activity (PA), cognition, academic performance and classroom behaviour. Design: Systematic review. Data sources: PubMed, EBSCO, Academic Search Complete, Education Resources Information Center, PsycINFO, SPORTDiscus, SCOPUS and Web of Science. Eligibility criteria for selecting studies: Studies investigating school-based acute bouts of CMB or PAL on (PA), cognition, academic performance and classroom behaviour...
2018: BMJ Open Sport & Exercise Medicine
João Morais, Mariam Bouhmadi-López, Manuel Krämer, Salvador Robles-Pérez
We analyze a quantized toy model of a universe undergoing eternal inflation using a quantum-field-theoretical formulation of the Wheeler-DeWitt equation. This so-called third quantization method leads to the picture that the eternally inflating universe is converted to a multiverse in which sub-universes are created and exhibit a distinctive phase in their evolution before reaching an asymptotic de Sitter phase. From the perspective of one of these sub-universes, we can thus analyze the pre-inflationary phase that arises naturally...
2018: European Physical Journal. C, Particles and Fields
Marie A Neu, Yasemin Tanyildizi, Arthur Wingerter, Nicole Henninger, Khalifa El Malki, Francesca Alt, Barbara Doerr, Heinz Schmidberger, Marcus Stockinger, Wolfgang Wagner, Stefanie Keweloh, Marc A Brockmann, Alexandra Russo, Joerg Faber
BACKGROUND AND PURPOSE: Due to sensitive neuroimaging techniques, cerebrovascular complications such as cerebral microbleeds (CMB) and cerebral cavernous malformations (CCM) are increasingly recognized as considerable late effects after treatment for pediatric brain tumor. The aim of this study was to analyze CMB in a cohort of patients after cranial irradiation therapy for medulloblastoma or other pediatric brain tumors using susceptibility-weighted magnetic resonance imaging (SWI). MATERIALS AND METHODS: Forty former pediatric brain tumor patients were enrolled in this prospective cross-sectional study and examined by cranial MRI including SWI sequences...
March 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Maurits G L Olthof, Diederik H R Kempen, Xifeng Liu, Mahrokh Dadsetan, Marianna A Tryfonidou, Michael J Yaszemski, Wouter J A Dhert, Lichun Lu
The optimal release profile of locally delivered BMP-2 for safe and effective clinical application is unknown. In this work, the effect of differential BMP-2 release on bone formation was investigated using a novel biomaterial oligo[(polyethylene glycol) fumarate] bis[2-(methacryloyloxy) ethyl] phosphate hydrogel (OPF-BP) containing poly(lactic-co-glycolic acid) microspheres. Three composite implants with same biomaterial chemistry and structure but different BMP-loading methods were created: BMP-2 encapsulated in microspheres (OPF-BP-Msp), BMP-2 encapsulated in microspheres and adsorbed on the phosphorylated hydrogel (OPF-BP-Cmb), and BMP-2 adsorbed on the phosphorylated hydrogel (OPF-BP-Ads)...
March 31, 2018: Journal of Tissue Engineering and Regenerative Medicine
A L Baltazar, G M de Mattos, B M Ropelli, Smg Firetti, C Castilho, G Pugliesi, Mbc Maldonado, M Binelli, Jof Silva, G C Lupatini, B S Lafuente, Cmb Membrive
Supplementation with compounds rich in linoleic acid, including sunflower seed supplementation, promotes increase in conception rates in cows. We aimed to evaluate whether the sunflower seed (linoleic acid source) supplementation in beef donor females alters the plasma concentrations of cholesterol, triglycerides, HDL and LDL, increases the number and quality of oocytes, increases the cleavage rates and determines an improvement in number and quality of in vitro produced blastocysts. Thus, Nelore females were divided into two groups of 15 animals to receive supplementation with or without sunflower seed for 57 days...
March 30, 2018: Reproduction in Domestic Animals, Zuchthygiene
Hongtao Song, Kui Lin, Jinglu Hu, Erli Pang
Background: Although the cucumber reference genome and its annotation were published several years ago, the functional annotation of predicted genes, particularly protein-coding genes, still requires further improvement. In general, accurately determining orthologous relationships between genes allows for better and more robust functional assignments of predicted genes. As one of the most reliable strategies, the determination of collinearity information may facilitate reliable orthology inferences among genes from multiple related genomes...
2018: Frontiers in Plant Science
Martin A Chacon-Portillo, Rafael H Llinas, Elisabeth B Marsh
BACKGROUND: Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrhage and can be seen on magnetic resonance imaging (MRI). In this study, we examined the association between CMBs and sICH, focusing on the predictive value of their presence, burden, and location. METHODS: Records from all patients presenting to two academic stroke centers with acute ischemic stroke treated with IV tPA over a 5-year period were retrospectively reviewed...
March 27, 2018: BMC Neurology
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