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https://www.readbyqxmd.com/read/28408200/angiogenesis-targeting-microbubbles-combined-with-ultrasound-mediated-gene-therapy-in-brain-tumors
#1
En-Ling Chang, Chien-Yu Ting, Po-Hong Hsu, Yu-Chun Lin, En-Chi Liao, Chiung-Yin Huang, Yuan-Chih Chang, Hong-Lin Chan, Chi-Shiun Chiang, Hao-Li Liu, Kuo-Chen Wei, Ching-Hsiang Fan, Chih-Kuang Yeh
The major challenges in gene therapy for brain cancer are poor transgene expression due to the blood-brain barrier (BBB) and neurologic damage caused by conventional intracerebral injection. Non-viral gene delivery using ultrasound-targeted microbubble (MB) oscillation via the systematic transvascular route is attractive, but there is currently no high-yielding and targeted gene expression method. In this study, we developed a non-viral and angiogenesis-targeting gene delivery approach for efficient brain tumor gene therapy without brain damage...
April 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28399464/surface-initiated-supplemental-activator-and-reducing-agent-atom-transfer-radical-polymerization-si-sara-atrp-of-4-vinylpyridine-on-poly-ethylene-terephthalate
#2
Mohamad Maaz, Tamara Elzein, Alice Bejjani, Nadine Barroca-Aubry, Bénédicte Lepoittevin, Diana Dragoe, Sandra Mazerat, Bilal Nsouli, Philippe Roger
Poly(ethylene terephthalate) (PET) substrates were modified by means of surface-initiated supplemental activator and reducing agent atom transfer radical polymerization (SI-SARA-ATRP) of 4-vinylpyridine (4VP). Substrates were pretreated in order to graft chloromethylbenzene (CMB) units capable of initiating the radical polymerization reaction of 4VP units. Surface characterization techniques, including Water Contact Angle (WCA), Attenuated Total Reflection (ATR), X-ray photoelectron spectroscopy (XPS), Atomic Force Microscopy (AFM) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) showed a successful grafting of a stable, smooth and homogenous layer of p4VP...
April 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28383912/chaunopyran-a-co-cultivation-of-marine-mollusk-derived-fungi-activates-a-rare-class-of-2-alkenyl-tetrahydropyran
#3
Zhuo Shang, Angela A Salim, Robert J Capon
Co-cultivation of Chaunopycnis sp. (CMB-MF028) and Trichoderma hamatum (CMB-MF030), fungal strains co-isolated from the inner tissue of an intertidal rock platform mollusc (Siphonaria sp), resulted in transcriptional activation of a rare class of 2-alkenyl-tetrahydropyran, chaunopyran A (7), and biotransformation and deactivation of the antifungal pyridoxatin (1), to methyl-pyridoxatin (8). This study illustrates the complexity of offensive and counter-offensive molecular defenses encountered during fungal co-cultivation, and the opportunities for activating new, otherwise transcriptionally silent secondary metabolites...
April 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28383269/talarolide-a-a-cyclic-heptapeptide-hydroxamate-from-an-australian-marine-tunicate-associated-fungus-talaromyces-sp-cmb-tu011
#4
Pradeep Dewapriya, Pritesh Prasad, Rakesh Damodar, Angela A Salim, Robert J Capon
A miniaturized 24-well plate microbioreactor approach was used to explore secondary metabolite media dependence in an Australian marine tunicate-associated fungus, Talaromyces sp. (CMB TU011). Detailed chemical investigations of an antifungal M1-saline cultivation yielded talarolide A (1), only the second reported natural cyclic peptide hydroxamate, and the first from a fungus. The antifungal properties of the M1-saline extract were attributed to the known diterpene glycoside sordarin (2). Structure elucidation of 1 and 2 was achieved by detailed spectroscopic analysis, with amino acid configurations in 1 assigned by the C3 and C18 Marfey's methods, and l-Ala and d-Ala regiochemistry by the recently reported 2D C3 Marfey's method...
April 6, 2017: Organic Letters
https://www.readbyqxmd.com/read/28364107/-advantage-of-extralevator-abdominoperineal-excision-comparing-to-the-conventional-abdominoperineal-excision-for-low-rectal-cancer-a-meta-analysis
#5
Qi Wang, Chengwen Xu, Jiajia Wang, Quan Ren, Jiaqing Cao
Whether extralevator abdominoperineal excision (ELAPE) improves survival and safety remains controversial. Systematic review of all comparative studies to define the superiority of ELAPE to conventional abdominoperineal excision (APE).
 Methods: Corresponding data, with case-control studies or cohorts regarding intraoperative perforation rate, the local recurrence rate and postoperative complications in the ELAPE group and the APE group, were retrieved from PubMed, Embase, the Cochrane Library, Chinese Biomedical Literature (CMB), VIP, China National Knowledge Infrastructure (CNKI), and Wanfang Database...
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28347929/cerebral-microbleeds-and-risk-of-incident-dementia-the-framingham-heart-study
#6
José R Romero, Alexa Beiser, Jayandra J Himali, Ashkan Shoamanesh, Charles DeCarli, Sudha Seshadri
Cerebral microbleeds (CMBs) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia: hypertensive and cerebral amyloid angiopathy. CMB detection in asymptomatic persons may help identify those at risk for dementia and may influence preventive strategies and design of clinical trials testing treatments for dementia. We studied the association of CMB with risk of incident dementia in community dwelling individuals. A total of 1296 dementia-free Framingham Heart Study participants (mean age 72 years; 54% women) with available brain MRI and incident dementia data during a mean follow-up period of 6...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28330241/purification-characterization-gene-cloning-and-expression-of-gh-10-xylanase-penicillium-citrinum-isolate-hzn13
#7
Zabin K Bagewadi, Sikandar I Mulla, Harichandra Z Ninnekar
An extracellular thermostable xylanase (Xyl-IIb) produced by Penicillium citrinum isolate HZN13 was purified to homogeneity using DEAE-Sepharose, Sephadex G-100 and Bio-Gel P-60 chromatography with specific activity of 6272.7 U/mg and 19.6-fold purification. The purification revealed the occurrence of multiple forms of xylanases (Xyl-I, Xyl-IIa, Xyl-IIb and Xyl-III). The molecular mass of highly purified Xyl-IIb was ~31 kDa with SDS-PAGE. The enzyme was cellulase-free, thermostable (55-75 °C) and acidophilic (3...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28318790/wood-burning-pollution-in-southern-chile-pm2-5-source-apportionment-using-cmb-and-molecular-markers
#8
Ana M Villalobos, Francisco Barraza, Héctor Jorquera, James J Schauer
Temuco is a mid-size city representative of severe wood smoke pollution in southern Chile; i.e., ambient 24-h PM2.5 concentrations have exceeded 150 μg/m(3) in the winter season and the top concentration reached 372 μg/m(3) in 2010. Annual mean concentrations have decreased but are still above 30 μg/m(3). For the very first time, a molecular marker source apportionment of ambient organic carbon (OC) and PM2.5 was conducted in Temuco. Primary resolved sources for PM2.5 were wood smoke (37.5%), coal combustion (4...
March 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28318355/dementia-incidence-and-predictors-in-cerebral-amyloid-angiopathy-patients-without-intracerebral-hemorrhage
#9
Li Xiong, Gregoire Boulouis, Andreas Charidimou, Duangnapa Roongpiboonsopit, Michael J Jessel, Marco Pasi, Yael D Reijmer, Panagiotis Fotiadis, Alison Ayres, Emily Merrill, Kristin Schwab, Deborah Blacker, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
Cerebral amyloid angiopathy (CAA) is a common cause of cognitive impairment in older individuals. This study aimed to investigate predictors of dementia in CAA patients without intracerebral hemorrhage (ICH). A total of 158 non-demented patients from the Stroke Service or the Memory Clinic who met the modified Boston Criteria for probable CAA were included. At baseline, neuroimaging markers, including lobar microbleeds (cerebral microbleeds (CMBs)), white matter hyperintensities (WMH), cortical superficial siderosis (cSS), magnetic resonance imaging (MRI)-visible centrum semiovale perivascular spaces (CSO-PVS), lacunes, and medial temporal atrophy (MTA) were assessed...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28303922/correlation-of-cerebral-microbleed-distribution-to-amyloid-burden-in-patients-with-primary-intracerebral-hemorrhage
#10
Hsin-Hsi Tsai, Li-Kai Tsai, Ya-Fang Chen, Sung-Chun Tang, Bo-Ching Lee, Ruoh-Fang Yen, Jiann-Shing Jeng
The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic resonance susceptibility-weighted imaging and (11)C-Pittsburgh Compound B positron emission tomography. The amyloid burden was expressed as standardized uptake value ratio with reference to cerebellum, and presented as median (interquartile range)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297352/improved-setup-and-positioning-accuracy-using-a-three-point-customized-cushion-mask-bite-block-immobilization-system-for-stereotactic-reirradiation-of-head-and-neck-cancer
#11
He Wang, Congjun Wang, Samuel Tung, Andrew Wilson Dimmitt, Pei Fong Wong, Mark A Edson, Adam S Garden, David I Rosenthal, Clifton D Fuller, Gary B Gunn, Vinita Takiar, Xin A Wang, Dershan Luo, James N Yang, Jennifer Wong, Jack Phan
The purpose of this study was to investigate the setup and positioning uncertainty of a custom cushion/mask/bite-block (CMB) immobilization system and determine PTV margin for image-guided head and neck stereotactic ablative radiotherapy (HN-SABR). We analyzed 105 treatment sessions among 21 patients treated with HN-SABR for recurrent head and neck cancers using a custom CMB immobilization system. Initial patient setup was performed using the ExacTrac infrared (IR) tracking system and initial setup errors were based on comparison of ExacTrac IR tracking system to corrected online ExacTrac X-rays images registered to treatment plans...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28276199/new-insights-into-a-hot-environment-for-early-life
#12
REVIEW
Jianghong Dai
Investigating the physical-chemical setting of early life is a challenging task. In this contribution, the author attempted to introduce a provocative concept from cosmology - cosmic microwave background (CMB), which is the residual thermal radiation from a hot early Universe - to the field. For this purpose, the author revisited a recently deduced biomarker, the 1,6-anhydro bond of sugars in bacteria. In vitro, the 1,6-anhydro bond of sugars reflects and captures residual thermal radiation in thermochemical processes and therefore is somewhat analogous to CMB...
March 9, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28263851/the-effects-of-different-exercise-training-modalities-on-plasma-proenkephalin-peptide-f-in-women
#13
William H DuPont, William J Kraemer, Bradley C Nindl, Elaine C Lee, Maren S Fragala, Disa L Hatfield, Lydia K Caldwell, Emily M Post, Matthew K Beeler, Jeff S Volek, Carl M Maresh
Due to the important interactions of proenkephalin fragments (e.g., proenkephalin [107-140] Peptide F) to enhance activation of immune cells and potentially combat pain associated with exercise-induced muscle tissue damage, we examined the differential plasma responses of Peptide F to different exercise training programs. Participants were tested pre-training (T1), and after 8 weeks (T2) of training. Fifty-nine healthy women were matched and then randomly assigned to one of four groups: heavy resistance strength training (STR, n=18), high intensity endurance training (END, n=14), combined strength and endurance training (CMB, n=17), or control (CON, n=10)...
March 3, 2017: Peptides
https://www.readbyqxmd.com/read/28255125/-meta-analysis-for-the-relationship-between-lipoprotein-associated-phospholipase-a2-and-ischemic-stroke
#14
Wencui Xia, Zhongyang Hu, Zhi Song
To analyze the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and ischemic stroke.
 Methods: Corresponding data, with case-control studies or cohorts regarding Lp-PLA2 and ischemic stroke, were retrieved from PubMed, Web of Science, Embase, the Cochrane Library, Chinese Biomedical Literature (CMB), VIP, China National Knowledge Infrastructure (CNKI), and Wanfang Database. Meta-analysis was performed by using Stata12.0.
 Results: Eight studies including 46 034 participants met the inclusion criteria...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28249488/a-cmos-application-specified-integrated-circuit-for-40-ghz-high-electron-mobility-transistors-automatic-biasing
#15
M De Matteis, M De Blasi, E A Vallicelli, M Zannoni, M Gervasi, A Bau, A Passerini, A Baschirotto
This paper presents the design and the experimental results of a CMOS Automatic Control System (ACS) for the biasing of High-Electron-Mobility-Transistors (HEMT). The ACS is the first low-power mixed-signal Application-Specified-Integrated-Circuit (ASIC) able to automatically set and regulate the operating point of an off-chip 6 HEMT Low-Noise-Amplifiers (LNAs), hence it composes a two-chip system (the ACS+LNAs) to be used in the Large Scale Polarization Explorer (LSPE) stratospheric balloon for Cosmic Microwave Background (CMB) signal observation...
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28228568/mri-visible-perivascular-spaces-in-cerebral-amyloid-angiopathy-and-hypertensive-arteriopathy
#16
Andreas Charidimou, Gregoire Boulouis, Marco Pasi, Eitan Auriel, Ellis S van Etten, Kellen Haley, Alison Ayres, Kristin M Schwab, Sergi Martinez-Ramirez, Joshua N Goldstein, Jonathan Rosand, Anand Viswanathan, Steven M Greenberg, M Edip Gurol
OBJECTIVE: To assess MRI-visible enlarged perivascular spaces (EPVS) burden and different topographical patterns (in the centrum semiovale [CSO] and basal ganglia [BG]) in 2 common microangiopathies: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). METHODS: Consecutive patients with spontaneous intracerebral hemorrhage (ICH) from a prospective MRI cohort were included. Small vessel disease MRI markers, including cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), and white matter hyperintensities (WMH), were rated...
March 21, 2017: Neurology
https://www.readbyqxmd.com/read/28207801/kidney-dysfunction-and-cerebral-microbleeds-in-neurologically-healthy-adults
#17
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
INTRODUCTION: Cerebral microbleed (CMB) is a potent risk factor for overt cerebrovascular disease. Although some studies indicated the possible role of renal dysfunction as a risk factor of CMB, the findings could not be generalized. This study aimed to investigate the association between renal dysfunction and cerebral microbleed (CMB) in neurologically healthy adults. MATERIALS AND METHODS: A total of 2,518 subjects who underwent brain MRI as part of health screening were involved in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28166727/whole-genome-sequencing-of-a-plasmodium-vivax-clinical-isolate-exhibits-geographical-characteristics-and-high-genetic-variation-in-china-myanmar-border-area
#18
Shen-Bo Chen, Yue Wang, Kokouvi Kassegne, Bin Xu, Hai-Mo Shen, Jun-Hu Chen
BACKGROUND: Currently in China, the trend of Plasmodium vivax cases imported from Southeast Asia was increased especially in the China-Myanmar border area. Driven by the increase in P. vivax cases and stronger need for vaccine and drug development, several P. vivax isolates genome sequencing projects are underway. However, little is known about the genetic variability in this area until now. RESULTS: The sequencing of the first P. vivax isolate from China-Myanmar border area (CMB-1) generated 120 million paired-end reads...
February 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28161268/source-apportionment-and-a-novel-approach-of-estimating-regional-contributions-to-ambient-pm2-5-in-haikou-china
#19
Baoshuang Liu, Tingkun Li, Jiamei Yang, Jianhui Wu, Jiao Wang, Jixin Gao, Xiaohui Bi, Yinchang Feng, Yufen Zhang, Haihang Yang
A novel approach was developed to estimate regional contributions to ambient PM2.5 in Haikou, China. In this paper, the investigation was divided into two main steps. The first step: analysing the characteristics of the chemical compositions of ambient PM2.5, as well as the source profiles, and then conducting source apportionments by using the CMB and CMB-Iteration models. The second step: the development of estimation approaches for regional contributions in terms of local features of Haikou and the results of source apportionment, and estimating regional contributions to ambient PM2...
April 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28157096/only-white-matter-hyperintensities-predicts-post-stroke-cognitive-performances-among-cerebral-small-vessel-disease-markers-results-from-the-tabasco-study
#20
Jeremy Molad, Efrat Kliper, Amos D Korczyn, Einor Ben Assayag, Dafna Ben Bashat, Shani Shenhar-Tsarfaty, Orna Aizenstein, Ludmila Shopin, Natan M Bornstein, Eitan Auriel
BACKGROUND: White matter hyperintensities (WMH) were shown to predict cognitive decline following stroke or transient ischemic attack (TIA). However, WMH are only one among other radiological markers of cerebral small vessel disease (SVD). OBJECTIVE: The aim of this study was to determine whether adding other SVD markers to WMH improves prediction of post-stroke cognitive performances. METHODS: Consecutive first-ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled...
2017: Journal of Alzheimer's Disease: JAD
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