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helicobacter pylori eradication in Japan

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https://www.readbyqxmd.com/read/27803739/vonoprazan-based-therapy-for-helicobacter-pylori-eradication-experience-and-clinical-evidence
#1
REVIEW
Yuko Akazawa, Daisuke Fukuda, Yutaka Fukuda
Stable suppression of gastric acid secretion is a crucial factor in Helicobacter pylori eradication. Vonoprazan is a potassium-competitive acid blocker recently approved for use in Japan. As vonoprazan has a long duration of action and causes rapid and strong inhibition of gastric acid secretion, it has gained clinical attention for treating erosive oesophagitis, peptic ulcers, and H. pylori infection. In this review, we discuss the recent knowledge regarding the safety and efficacy of vonoprazan, focusing on its use in H...
November 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27698544/esomeprazole-or-rabeprazole-based-triple-therapy-eradicated-helicobacter-pylori-comparably-regardless-of-clarithromycin-susceptibility-and-cyp2c19-genotypes
#2
Tadayoshi Okimoto, Kazuhiro Mizukami, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Kensuke Fukuda, Masaaki Kodama, Kazunari Murakami
The aim of this study was to assess the efficacy of esomeprazole-based triple therapy compared with rabeprazole-based triple therapy according to CYP2C19 genotype and clarithromycin susceptibility status for first-line eradication therapy of Helicobacter pylori (H. pylori) in Japan. We enrolled 219 H. pylori-infected patients, and randomly allocated patients to the EAC group (esomeprazole 20 mg, clarithromycin 200 mg, amoxicillin 750 mg for one week, with all drugs given twice daily) or RAC group (rabeprazole 10 mg, clarithromycin 200 mg, amoxicillin 750 mg for one week, with all drugs given twice daily)...
September 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27689190/a-novel-potassium-competitive-acid-blocker-improves-the-efficacy-of-clarithromycin-containing-7-day-triple-therapy-against-helicobacter-pylori
#3
Hisatsugu Noda, Seiji Noguchi, Takashi Yoshimine, Shigeki Goji, Kazunori Adachi, Yasuhiro Tamura, Shinya Izawa, Masahide Ebi, Sayuri Yamamoto, Naotaka Ogasawara, Yasushi Funaki, Makoto Sasaki, Kunio Kasugai
BACKGROUND AND AIMS: In Japan, 7-day triple therapy for Helicobacter pylori including clarithromycin (CAM) was approved in 2000. However, antibiotic resistance subsequently reduced this rate to an unacceptable level (70%). Vonoprazan, an orally bioavailable potassium-competitive acid blocker (P-CAB), was approved in Japan in 2014. This could improve eradication rates by increasing the intragastric pH, thus increasing bacterial antibiotic susceptibility. This study compared the efficacy of 7-day triple therapies that included CAM and vonoprazan or proton pump inhibitor (PPI)...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27659671/helicobacter-pylori-eradication-with-proton-pump-inhibitors-or-potassium-competitive-acid-blockers-the-effect-of-clarithromycin-resistance
#4
Hiroshi Matsumoto, Akiko Shiotani, Ryo Katsumata, Minoru Fujita, Rui Nakato, Takahisa Murao, Manabu Ishii, Tomoari Kamada, Ken Haruma, David Y Graham
BACKGROUND: Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) recently approved for Helicobacter pylori eradication therapy in Japan. AIMS: To compare PPI- and P-CAP-containing triple therapy and vonoprazan-based triple therapy. METHODS: Two hundred ninety-five initial subjects received a PPI-containing triple therapy; the next 125 subjects received vonoprazan-containing triple therapy. Two sequential groups received 7-day eradication regimens consisting of amoxicillin 750 mg, clarithromycin 200 mg both twice a day with standard dose PPI or vonoprazan (20 mg) each twice daily...
November 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27374672/association-of-hay-fever-with-the-failure-of-helicobacter-pylori-primary-eradication
#5
Kayoko Ozeki, Takahisa Furuta, Michio Asano, Tatsuya Noda, Mieko Nakamura, Yosuke Shibata, Eisaku Okada, Toshiyuki Ojima
Objective Recently, the number of patients receiving Helicobacter pylori eradication treatment has dramatically increased in Japan, although the eradication rate has gradually decreased. Patient characteristics could affect the eradication rate. Our aim in this study was to investigate the association between failed first-line eradication therapy and hay fever. Methods We researched 356 patients who visited a pharmacy adjacent to the Internal Medicine clinic with a prescription for first-line H. pylori eradication treatment and investigated whether the patients had hay fever using a questionnaire...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27223686/nationwide-survey-of-helicobacter-pylori-treatment-for-children-and-adolescents-in-japan
#6
Masumi Okuda, Shogo Kikuchi, Katsuhiro Mabe, Takako Osaki, Shigeru Kamiya, Yoshihiro Fukuda, Mototsugu Kato
BACKGROUND: To prevent gastric cancer, a test-and-treat strategy for Helicobacter pylori has been proposed. This retrospective study assessed the clinical features, efficacy and safety of treatment for H. pylori infection in children and adolescents. METHODS: Questionnaires concerning the clinical features and treatment of H. pylori in children and adolescents were sent to doctors in 2013. It included questions on patient background, H. pylori-associated disease, first- and second-line treatment, success or failure of eradication, resistance to antibiotics, and occurrence of adverse events...
May 25, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27213463/four-times-daily-dosing-of-rabeprazole-with-sitafloxacin-high-dose-amoxicillin-or-both-for-metronidazole-resistant-infection-with-helicobacter-pylori-in-japan
#7
Mitsushige Sugimoto, Shu Sahara, Hitomi Ichikawa, Takuma Kagami, Hiromitsu Ban, Taketo Otsuka, Akira Andoh, Takahisa Furuta
BACKGROUND: The bacterial resistance of Helicobacter pylori to antimicrobial agents such as clarithromycin and metronidazole has been increasing worldwide, leading to the failure of eradication treatment. Here, we present an eradication regimen consisting of four-times-daily dosing (q.i.d.) of rabeprazole with potent acid inhibition. AIM: To investigate the efficacy of eradication therapy with rabeprazole q.i.d. and amoxicillin or sitafloxacin in Japanese infected with a metronidazole-resistant strain...
May 23, 2016: Helicobacter
https://www.readbyqxmd.com/read/27043835/onset-of-ulcerative-colitis-after-helicobacter-pylori-eradication-therapy-a-case-report
#8
Mitsuro Chiba, Tsuyotoshi Tsuji, Kenichi Takahashi, Masafumi Komatsu, Takeshi Sugawara, Iwao Ono
In Japan, Helicobacter pylori eradication has been approved since 2013 for treatment of H pylori-induced chronic gastritis, in an attempt to reduce the prevalence of gastric cancer, a leading cancer in Japan. H pylori infection affects more than 50% of the world's population. H pylori eradication therapy is generally safe. To our knowledge, no case of newly diagnosed ulcerative colitis occurring immediately after H pylori eradication therapy has previously been reported.A 63-year-old man received a diagnosis of chronic gastritis and H pylori infection...
2016: Permanente Journal
https://www.readbyqxmd.com/read/26900095/guidelines-for-endoscopic-management-of-non-variceal-upper-gastrointestinal-bleeding
#9
REVIEW
Mitsuhiro Fujishiro, Mikitaka Iguchi, Naomi Kakushima, Motohiko Kato, Yasuhisa Sakata, Shu Hoteya, Mikinori Kataoka, Shunji Shimaoka, Naohisa Yahagi, Kazuma Fujimoto
Japan Gastroenterological Endoscopy Society (JGES) has compiled a set of guidelines for endoscopic management of non-variceal upper gastrointestinal bleeding using evidence-based methods. The major cause of non-variceal upper gastrointestinal bleeding is peptic gastroduodenal ulcer bleeding. As a result, these guidelines mainly focus on peptic gastroduodenal ulcer bleeding, although bleeding from other causes is also overviewed. From the epidemiological aspect, in recent years in Japan, bleeding from drug-related ulcers has become predominant in comparison with bleeding from Helicobacter pylori (HP)-related ulcers, owing to an increase in the aging population and coverage of HP eradication therapy by national health insurance...
May 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/26796535/questionnaire-based-survey-on-diagnostic-and-therapeutic-endoscopies-and-h-pylori-eradication-for-elderly-patients-in-east-asian-countries
#10
Juntaro Matsuzaki, Ryoma Hayashi, Tetsuo Arakawa, Fumiaki Ueno, Yoshikazu Kinoshita, Takashi Joh, Shin'ichi Takahashi, Yuji Naito, Shin Fukudo, Francis K L Chan, Ki-Baik Hahm, Udom Kachintorn, Kwong Ming Fock, Ari Fahrial Syam, Abdul Aziz Rani, Jose D Sollano, Qi Zhu, Yasuhiro Fujiwara, Eiji Kubota, Hiromi Kataoka, Kengo Tokunaga, Kazuhiko Uchiyama, Hidekazu Suzuki
BACKGROUND: Gastrointestinal endoscopy and Helicobacter pylori(H. pylori) eradication therapy are commonly performed even among the elderly population. The aim of this study was to understand the way endoscopists viewed the application of endoscopy and H. pylori eradication in the elderly of East Asian countries. METHODS: Self-administered questionnaires containing 13 questions on endoscopy and H. pylori eradication in the elderly were distributed to major institutions in Japan, South Korea, China, Indonesia, and the Philippines...
2016: Digestion
https://www.readbyqxmd.com/read/26789391/gastroesophageal-reflux-disease-in-time-covering-eradication-for-all-patients-infected-with-helicobacter-pylori-in-japan
#11
Mitsushige Sugimoto, Takahiro Uotani, Hitomi Ichikawa, Akira Andoh, Takahisa Furuta
BACKGROUND: The prevalence of gastroesophageal reflux disease (GERD) has increased in Japan since the end of the 20th century due to changes in environmental factors, such as a decreased infection rate of Helicobacter pylori and increased ability of acid secretion in the Japanese population. In 2013, the Japanese health insurance system started to cover eradication treatment for all patients infected with H. pylori to prevent gastric cancer, suggesting we may soon be able to completely eradicate this infection in Japan...
2016: Digestion
https://www.readbyqxmd.com/read/26694080/review-article-the-global-emergence-of-helicobacter-pylori-antibiotic-resistance
#12
REVIEW
I Thung, H Aramin, V Vavinskaya, S Gupta, J Y Park, S E Crowe, M A Valasek
BACKGROUND: Helicobacter pylori is one of the most prevalent global pathogens and can lead to gastrointestinal disease including peptic ulcers, gastric marginal zone lymphoma and gastric carcinoma. AIM: To review recent trends in H. pylori antibiotic resistance rates, and to discuss diagnostics and treatment paradigms. METHODS: A PubMed literature search using the following keywords: Helicobacter pylori, antibiotic resistance, clarithromycin, levofloxacin, metronidazole, prevalence, susceptibility testing...
February 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26691187/-unpleasant-journey-from-helicobacter-pylori-associated-gastritis-to-gastric-cancer-cancer-prevention-by-taking-a-detour
#13
Sang Hwan Lee, Jong Min Park, Young Min Han, Weon Jin Ko, Ki Baik Hahm
As a commensal or a pathogen, Helicobacter pylori can change the balance of a complex interaction that exists among gastric epithelial cells, microbes, and their environment. Therefore, unraveling this complex relationship of these mixtures can be expected to help prevent cancer as well as troublesome unmet medical needs of H. pylori infection. Though gastric carcinogenesis is a multi-step process, precancerous lesion can be reversible in the early phase of mucosal damage before reaching the stage of no return...
December 2015: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/26672968/an-update-on-helicobacter-pylori-as-the-cause-of-gastric-cancer
#14
REVIEW
Wei Zhang, Hong Lu, David Y Graham
BACKGROUND: Gastric cancer is the second most common cause of cancer deaths worldwide. The vast majority of gastric cancers are inflammation-related cancers caused by infection with Helicobacter pylori. H. pylori-induced oxidative stress damages DNA, resulting in genetic instability. In addition, H. pylori itself can cause DNA damage and epigenetic changes that trigger genetic instability and neoplastic transformation. SUMMARY: H. pylori strain-specific components act in combination with host factors and environmental and dietary factors to greatly enhance the inflammatory response and thus the cancer risk...
August 2014: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/26651251/screening-of-gastric-cancer-in-asia
#15
REVIEW
Kentaro Sugano
In North-Eastern Asian countries, where incidence and mortality of gastric cancer remain very high, population-based gastric cancer screenings have been conducted under governmental subsidy in Japan and Korea. Reduction of gastric cancer mortality by the screening was documented in Japan, but the Japanese gastric cancer screening with the X-ray photofluorography is criticized for its high cost and a low uptake rate. Although the Korean program seems to achieve a high-rate of uptake with increasing use of endoscopy, the work load is substantial...
December 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26486508/atrophic-gastritis-and-enlarged-gastric-folds-diagnosed-by-double-contrast-upper-gastrointestinal-barium-x-ray-radiography-are-useful-to-predict-future-gastric-cancer-development-based-on-the-3-year-prospective-observation
#16
Nobutake Yamamichi, Chigaya Hirano, Masao Ichinose, Yu Takahashi, Chihiro Minatsuki, Rie Matsuda, Chiemi Nakayama, Takeshi Shimamoto, Shinya Kodashima, Satoshi Ono, Yosuke Tsuji, Keiko Niimi, Yoshiki Sakaguchi, Yosuke Kataoka, Itaru Saito, Itsuko Asada-Hirayama, Chihiro Takeuchi, Seiichi Yakabi, Hikaru Kaikimoto, Yuta Matsumoto, Daisuke Yamaguchi, Natsuko Kageyama-Yahara, Mitsuhiro Fujishiro, Ryoichi Wada, Toru Mitsushima, Kazuhiko Koike
BACKGROUND: Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated. METHODS: We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants...
July 2016: Gastric Cancer
https://www.readbyqxmd.com/read/26420267/incidence-of-and-risk-factors-for-metachronous-gastric-cancer-after-endoscopic-resection-and-successful-helicobacter-pylori-eradication-results-of-a-large-scale-multicenter-cohort-study-in-japan
#17
Genki Mori, Takeshi Nakajima, Kiyoshi Asada, Taichi Shimazu, Nobutake Yamamichi, Takao Maekita, Chizu Yokoi, Mitsuhiro Fujishiro, Takuji Gotoda, Masao Ichinose, Toshikazu Ushijima, Ichiro Oda
BACKGROUND: A previous multicenter prospective randomized study from Japan showed that Helicobacter pylori eradication reduced the development of metachronous gastric cancer (MGC) after endoscopic resection for early gastric cancer. MGC risk, however, is not eliminated; yet few studies have evaluated its long-term incidence and risk factors. In this study, we investigated the incidence of and risk factors for MGC in patients who underwent endoscopic resection for early gastric cancer with successful H...
July 2016: Gastric Cancer
https://www.readbyqxmd.com/read/26369775/the-first-in-class-potassium-competitive-acid-blocker-vonoprazan-fumarate-pharmacokinetic-and-pharmacodynamic-considerations
#18
Hirotoshi Echizen
Vonoprazan fumarate (Takecab) is a first-in-class potassium-competitive acid blocker that has been available in the market in Japan since February 2015. Vonoprazan is administered orally at 20 mg once daily for the treatment of gastroduodenal ulcer, at 20 and 10 mg once daily for the treatment and secondary prevention of reflux esophagitis, respectively, at 10 mg once daily for the secondary prevention of low-dose aspirin- or non-steroidal anti-inflammatory drug-induced peptic ulcer, and at 20 mg twice daily in combination with clarithromycin and amoxicillin for the eradication of Helicobacter pylori...
April 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/26314676/screening-to-identify-and-eradicate-helicobacter-pylori-infection-in-teenagers-in-japan
#19
Taiji Akamatsu, Takuma Okamura, Yugo Iwaya, Tomoaki Suga
The purpose of this study was to elucidate the prevalence and effect of Helicobacter pylori infection in Japanese teenagers. The study subjects were students ages 16 to 17 from one high school studied between 2007 and 2013. Students who tested positive on this screening examination underwent esophagogastroduodenoscopy and biopsy samples to determine their H pylori status using culture and histology. Cure of H pylori infections was determined by urea breath test. The low rate of prevalence of H pylori infection in present Japanese teenagers makes it possible and cost effective to perform examinations and carry out treatment of this infection in nationwide health screenings of high school students...
September 2015: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/26314673/helicobacter-pylori-eradication-to-eliminate-gastric-cancer-the-japanese-strategy
#20
REVIEW
Masahiro Asaka, Katsuhiro Mabe, Rumiko Matsushima, Momoko Tsuda
Helicobacter pylori eradication therapy for chronic gastritis achieved world-first coverage by the Japanese national health insurance scheme in 2013, making a dramatic decrease of gastric cancer-related deaths more realistic. Combining H pylori eradication therapy with endoscopic surveillance can prevent the development of gastric cancer. Even if it develops, most patients are likely to be diagnosed at an early stage, possibly resulting in fewer gastric cancer deaths. Success with the elimination of gastric cancer in Japan could lead other countries with a high incidence to consider a similar strategy, suggesting the potential for elimination of gastric cancer around the world...
September 2015: Gastroenterology Clinics of North America
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