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Vascular smooth muscle cells, aging

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https://www.readbyqxmd.com/read/29670546/-in-utero-exposure-to-maternal-diabetes-is-associated-with-early-abnormal-vascular-structure-in-offspring
#1
Abdallah Dib, Cyrielle Payen, Jennifer Bourreau, Mathilde Munier, Linda Grimaud, Ziad Fajloun, Laurent Loufrani, Daniel Henrion, Céline Fassot
Aim/hypothesis: In utero exposure to maternal diabetes increases the risk of developing hypertension and cardiovascular disorders during adulthood. We have previously shown that this is associated with changes in vascular tone in favor of a vasoconstrictor profile, which is involved in the development of hypertension. This excessive constrictor tone has also a strong impact on vascular structure. Our objective was to study the impact of in utero exposure to maternal diabetes on vascular structure and remodeling induced by chronic changes in hemodynamic parameters...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29653075/inhibition-of-semicarbazide-sensitive-amine-oxidase-reduces-atherosclerosis-in-apolipoprotein-e-deficient-mice
#2
Shu-Huei Wang, Tse-Ya Yu, Feng-Chiao Tsai, Chris J Weston, Mao-Shin Lin, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Solé, Mercedes Unzeta, Yuh-Lien Chen, Lee-Ming Chuang, Hung-Yuan Li
Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarbazide-sensitive amine oxidase (SSAO) activity, which catalyzes oxidative deamination to produce hydrogen peroxide and aldehydes, leading to generation of AGEs and ALEs. However, the effect of VAP-1/SSAO inhibition on atherosclerosis remains controversial, and no studies used coronary angiography to evaluate if plasma VAP-1/SSAO is a biomarker for coronary artery disease (CAD)...
March 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29620941/cerebrovascular-%C3%AE-amyloid-deposition-and-associated-microhemorrhages-in-a-tg2576-alzheimer-mouse-model-are-reduced-with-a-dha-enriched-diet
#3
Justine Hur, Véronique Mateo, Nicolas Amalric, Mégane Babiak, Gilbert Béréziat, Claire Kanony-Truc, Thierry Clerc, Régis Blaise, Isabelle Limon
Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis. Like AD, CAA is often accompanied by marked inflammation, aggravating associated vasculopathies. No evidence-based prevention or treatment strategies are available. Here, we evaluate the possible beneficial effect of a diet enriched with docosahexaenoic acid (DHA), which is known to attenuate inflammation in CAA. Tg2576 mice, a transgenic model of AD/CAA, were fed a DHA-enriched diet starting at 2 mo of age and ending at 10, 14, or 18 mo of age...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29603864/vascular-smooth-muscle-cells-direct-extracellular-dysregulation-in-aortic-stiffening-of-hypertensive-rats
#4
Tristan T Hays, Ben Ma, Ning Zhou, Shaunrick Stoll, William J Pearce, Hongyu Qiu
Aortic stiffening is an independent risk factor that underlies cardiovascular morbidity in the elderly. We have previously shown that intrinsic mechanical properties of vascular smooth muscle cells (VSMCs) play a key role in aortic stiffening in both aging and hypertension. Here, we test the hypothesis that VSMCs also contribute to aortic stiffening through their extracellular effects. Aortic stiffening was confirmed in spontaneously hypertensive rats (SHRs) vs. Wistar-Kyoto (WKY) rats in vivo by echocardiography and ex vivo by isometric force measurements in isolated de-endothelized aortic vessel segments...
March 30, 2018: Aging Cell
https://www.readbyqxmd.com/read/29603682/adipose-derived-stem-cells-improve-erectile-function-partially-through-the-secretion-of-igf-1-bfgf-and-vegf-in-aged-rats
#5
J Yang, Y Zhang, G Zang, T Wang, Z Yu, S Wang, Z Tang, J Liu
Adipose-derived stem cells (ADSCs) have recently been considered as a promising therapy for erectile dysfunction (ED). However, the mechanism of ADSC-based therapy is unclear. Insulin-like growth factor-1 (IGF-1), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) secreted by ADSCs were assessed in vitro. Sixteen 24-month-old male Sprague-Dawley rats were used for comparative analysis of 2-week treatment with labeled ADSCs or PBS. Eight additional 5-month-old rats were used as a young rat group...
March 30, 2018: Andrology
https://www.readbyqxmd.com/read/29577514/gene-expression-profiles-of-ion-channels-and-receptors-in-mouse-resistance-arteries-effects-of-cell-type-vascular-bed-and-age
#6
Erika M Boerman, Sen Sidharth, Rebecca L Shaw, Trupti Joshi, Steven S Segal
OBJECTIVE: Receptors and ion channels of smooth muscle cells (SMCs) and endothelial cells (ECs) are integral to the regulation of vessel diameter and tissue blood flow. Physiological roles of ion channels and receptors in skeletal muscle and mesenteric arteries have been identified however their gene expression profiles are undefined. We tested the hypothesis that expression profiles for ion channels and receptors governing vascular reactivity vary with cell type, vascular bed and age...
March 25, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29572322/sp1-plays-an-important-role-in-vascular-calcification-both-in-vivo-and-in-vitro
#7
Xinyu Zhang, Rui Li, Xiaoteng Qin, Lei Wang, Jie Xiao, Yu Song, Xi Sheng, Mengqi Guo, Xiaoping Ji
BACKGROUND: Vascular calcification and increased cardiovascular morbidity and mortality are closely related in patients with end-stage renal disease and diabetes mellitus. Specific protein 1 (Sp1) is a transactivation molecule that plays a crucial role in the regulation of apoptosis, fibrosis, angiogenesis, and other pathological disorders. There is evidence that specific protein 1 (Sp1) directly stimulates the transcription of bone morphogenetic protein 2 (BMP2) and that BMP2 plays a key role in the calcification process in the BMP2-expressing F9 cell model system...
March 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29566305/ginsenoside-rg3-stereoisomers-differentially-inhibit-vascular-smooth-muscle-cell-proliferation-and-migration-in-diabetic-atherosclerosis
#8
Mengqi Guo, Guanlun Guo, Jie Xiao, Xi Sheng, Xinyu Zhang, Yuanyuan Tie, Yuen-Kit Cheng, Xiaoping Ji
Ginsenoside 20(R/S)-Rg3, as a natural peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to exhibit differential biological effects. It is of great interest to understand the stereochemical selectivity of 20(R/S)-Rg3 and explore whether differential PPARγ activation by Rg3 stereoisomers, if it exists, could lead to differential physiological outcome and therapeutic effects in diabetic atherosclerosis. Here, we investigated the binding modes of 20(R/S)-Rg3 stereoisomers in the PPARγ ligand-binding domain (PPARγ-LBD) using molecular modelling and their effects on smooth muscle cell proliferation and migration induced by advanced glycation end products (AGEs)...
March 22, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29556500/vascular-senescence-in-cardiovascular-and-metabolic-diseases
#9
Goro Katsuumi, Ippei Shimizu, Yohko Yoshida, Tohru Minamino
In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce "cellular senescence", which is characterized by growth arrest and alteration of the gene expression profile. Chronological aging is associated with development of age-related diseases, including heart failure, diabetes, and atherosclerotic disease, and studies have shown that accumulation of senescent cells has a causative role in the pathology of these age-related disorders...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29548814/renin-and-aldosterone-are-not-associated-with-vulnerable-plaque-characteristics-in-patients-with-carotid-artery-disease
#10
Marieke A Hillaert, Hester M den Ruijter, Imo E Hoefer, Eef G Lentjes, Gert J de Borst, Jean-Paul P M de Vries, Pieter A Doevendans, Gerard Pasterkamp, Leo Timmers
BACKGROUND: The renin-angiotensin-aldosterone system is increasingly being recognized to play an important role in the development and clinical course of cardiovascular diseases. Renin-angiotensin-aldosterone system activation is associated with clinical outcome in various populations of cardiovascular patients, such as patients with coronary artery, peripheral artery, and cerebrovascular disease. In this study, we investigated the associations between plasma renin and aldosterone concentrations and atherosclerotic plaque characteristics and secondary vascular events in patients undergoing carotid endarterectomy...
March 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29528383/neuregulin-1-attenuates-stress-induced-vascular-senescence
#11
Hadis Shakeri, Andreas B Gevaert, Dorien M Schrijvers, Guido R Y De Meyer, Gilles W De Keulenaer, Pieter-Jan D F Guns, Katrien Lemmens, Vincent F Segers
Aims: Cardiovascular ageing is a key determinant of life expectancy. Cellular senescence, a state of irreversible cell cycle arrest, is an important contributor to ageing due to the accumulation of damaged cells. Targeting cellular senescence could prevent age-related cardiovascular diseases. In this study, we investigated the effects of neuregulin-1 (NRG-1), an epidermal growth factor with cardioprotective and anti-atherosclerotic effects, on cellular senescence. Methods & results: Senescence was induced in cultured rat aortic endothelial cells (ECs) and aortic smooth muscle cells (SMCs) by 2 hours exposure to 30 µM hydrogen peroxide (H2O2)...
March 8, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29525729/immunophenotypic-analysis-of-the-chronological-events-of-tissue-repair-in-aortic-medial-dissections
#12
Silvia D Visonà, Onno J de Boer, Claire Mackaaij, Hans H de Boer, Kartika R Pertiwi, Ruben W de Winter, Antonio Osculati, Allard C van der Wal
Acute medial dissection of aorta can occur in the context of a sudden and unexpected death. For medico-legal reasons it is important to estimate as accurately the histological age of dissections. We evaluated the additional value of a systematic application of immunohistochemistry, compared with conventional histology only, in determining chronological steps of injury and repair. Thirty two paraffin embedded specimens of aortic dissection were retrospectively allocated to one of four defined stages: acute (I), subacute (II), early organizing (III) and scarring (IV) using Hematoxylin and Eosin and Elastica van Gieson stained sections...
February 10, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29520172/fluvastatin-inhibits-advanced-glycation-end-products-induced-proliferation-migration-and-extracellular-matrix-accumulation-in-vascular-smooth-muscle-cells-by-targeting-connective-tissue-growth-factor
#13
Ae-Rang Hwang, Ju-Ock Nam, Young Jin Kang
Connective tissue growth factor (CTGF) is a novel fibrotic mediator, which is considered to mediate fibrosis through extracellular matrix (ECM) synthesis in diabetic cardiovascular complications. Statins have significant immunomodulatory effects and reduce vascular injury. We therefore examined whether fluvastatin has anti-fibrotic effects in vascular smooth muscle cells (VSMCs) and elucidated its putative transduction signals. We show that advanced glycation end products (AGEs) stimulated CTGF mRNA and protein expression in a time-dependent manner...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29514202/role-of-smooth-muscle-cells-in-vascular-calcification-implications-in-atherosclerosis-and-arterial-stiffness
#14
Andrew L Durham, Mei Y Speer, Marta Scatena, Cecilia M Giachelli, Catherine M Shanahan
Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC) transdifferentiation within the vascular wall. Historically, VSMC phenotype switching has been viewed as binary, with the cells able to adopt a physiological contractile phenotype or an alternate 'synthetic' phenotype in response to injury. More recent work, including lineage tracing has however revealed that VSMCs are able to adopt a number of phenotypes, including calcific (osteogenic, chondrocytic, and osteoclastic), adipogenic, and macrophagic phenotypes...
March 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29514201/smooth-muscle-cell-and-arterial-aging-basic-and-clinical-aspects
#15
Patrick Lacolley, Veronique Regnault, Alberto P Avolio
Arterial aging engages a plethora of key signalling pathways that act in concert to induce vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration and extracellular matrix degradation responsible for alterations of the mechanical properties of the vascular wall. This review highlights proof-of-concept examples of components of the extracellular matrix, VSMC receptors which connect extracellular and intracellular structures, and signalling pathways regulating changes in mechanotransduction and vascular homeostasis in aging...
March 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29505793/evaluation-of-the-toxic-effects-of-celecoxib-on-xenopus-embryo-development
#16
Yeon-Hee Yoon, Ji Yoon Kim, Yong Chul Bae, Sung-Wook Nam, Hee-Jung Cho, Suho Lee, Ho Young Chung, Hyun-Shik Lee, Mae-Ja Park
Celecoxib is a non-steroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 and is prescribed for severe pain and inflammation. The excellent therapeutic effects of celecoxib mean that it is frequently used clinically, including for women of child-bearing age. However, the prenatal effects of this compound have not been studied extensively in vertebrates. The present study examined the developmental toxicity of celecoxib using a frog embryo teratogenic assay-Xenopus (FETAX). In addition, we examined its effects on cell migration using co-cultures of human umbilical vein endothelial cells and 10T1/2 cells...
March 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29494675/indoleamine-2-3-dioxygenase-knockout-limits-angiotensin-ii-induced-aneurysm-in-low-density-lipoprotein-receptor-deficient-mice-fed-with-high-fat-diet
#17
Sarvenaz Metghalchi, Marie Vandestienne, Yacine Haddad, Bruno Esposito, Julien Dairou, Alain Tedgui, Ziad Mallat, Stephane Potteaux, Soraya Taleb
AIMS: Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in identifying targets involved in these processes, therapeutic approaches aiming to reduce aneurysm growth and rupture are still scarce. Indoleamine 2-3 dioxygenase 1 (IDO) is the first and rate-limiting enzyme involved in the conversion of tryptophan (Trp) into kynurenine (Kyn) pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29490993/vascular-smooth-muscle-specific-progerin-expression-accelerates-atherosclerosis-and-death-in-a-mouse-model-of-hutchinson-gilford-progeria-syndrome
#18
Magda R Hamczyk, Ricardo Villa-Bellosta, Pilar Gonzalo, María J Andrés-Manzano, Paula Nogales, Jacob F Bentzon, Carlos López-Otín, Vicente Andrés
Background -Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). HGPS patients with ubiquitous progerin expression exhibit accelerated aging and atherosclerosis, and die in their early teens mainly from myocardial infarction or stroke. The mechanisms underlying progerin-induced atherosclerosis remain unexplored, in part due to the lack of appropriate animal models. Methods -We generated an atherosclerosis-prone model of HGPS by crossing apolipoprotein E-deficient ( Apoe-/- ) mice with LmnaG609G/G609G mice ubiquitously expressing progerin...
February 28, 2018: Circulation
https://www.readbyqxmd.com/read/29490308/lower-serum-irisin-levels-are-associated-with-increased-vascular-calcification-in-hemodialysis-patients
#19
Lian He, Wan-Yu He, La-Ta A, Wen-Ling Yang, Ai-Hua Zhang
BACKGROUND/AIMS: Vascular calcification, which involves an active cellular transformation of vascular smooth muscle cells into bone forming cells, is prevalent and predicts mortality in dialysis patients. Its mechanisms are complex and unclear. We presume that irisin, a newly identified myokine also may play roles in vascular calcification in hemodialysis patients. This study aims to evaluate serum irisin levels and establish their relation to vascular calcification and other parameters in hemodialysis patients...
February 22, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29469613/aging-and-anatomical-variations-in-lung-tissue-stiffness
#20
Delphine Sicard, Andrew J Haak, Kyoung Moo Choi, Alexandria R Craig, Laura E Fredenburgh, Daniel J Tschumperlin
Lung function is inherently mechanical in nature, and depends on the capacity to conduct air and blood to and from the gas exchange regions. Variations in the elastic properties of the human lung across anatomical compartments and with aging are likely important determinants of lung function, but remain relatively poorly characterized. Here we applied atomic force microscopy to characterize human lung tissue from subjects ranging in age from 11 to 60 years old. We observed striking anatomical variations in elastic modulus, with the airways (200-350 µm diameter) the stiffest and the parenchymal regions the most compliant...
February 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
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