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https://www.readbyqxmd.com/read/27899525/reactive-oxygen-species-induce-virus-independent-mavs-oligomerization-in-systemic-lupus-erythematosus
#1
Iwona A Buskiewicz, Theresa Montgomery, Elizabeth C Yasewicz, Sally A Huber, Michael P Murphy, Richard C Hartley, Ryan Kelly, Mary K Crow, Andras Perl, Ralph C Budd, Andreas Koenig
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with retinoic acid gene I (RIG-I)-like helicases during viral infection, was activated by oxidative stress independently of RIG-I helicases. We found that chemically generated oxidative stress stimulated the formation of MAVS oligomers, which led to mitochondrial hyperpolarization and decreased adenosine triphosphate production and spare respiratory capacity, responses that were not observed in similarly treated cells lacking MAVS...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27897608/modulating-oxidative-stress-and-inflammation-in-elders-the-moxie-study
#2
Amy Cameron Ellis, Tanja Dudenbostel, Julie L Locher, Kristi Crowe-White
Cardiovascular disease (CVD) is the leading cause of death among women in the United States. Endothelial dysfunction and arterial stiffness increase with advancing age and are early predictors of future CVD outcomes. We designed the Modulating Oxidative Stress and Inflammation in Elders (MOXIE) study to examine the effects of 100% watermelon juice as a "food-first" intervention to reduce CVD risk among African American (AA) and European American (EA) women aged 55-69 years. Vascular dysfunction is more pronounced in AA compared to EA women due in part to lower nitric oxide bioavailability caused by higher oxidative stress...
October 2016: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27893231/trajectories-of-higher-and-lower-order-dimensions-of-negative-and-positive-affect-relative-to-restrictive-eating-in-anorexia-nervosa
#3
Ann F Haynos, Kelly C Berg, Li Cao, Ross D Crosby, Jason M Lavender, Linsey M Utzinger, Stephen A Wonderlich, Scott G Engel, James E Mitchell, Daniel Le Grange, Carol B Peterson, Scott J Crow
Despite robust support for the role of affect in the maintenance of binge eating and purging, the relationship between affect and restrictive eating remains poorly understood. To investigate the relationship between restrictive eating and affect, ecological momentary assessment data from 118 women with anorexia nervosa (AN) were used to examine trajectories of higher-order dimensions of negative affect (NA) and positive affect (PA), as well as lower-order dimensions of NA (Fear, Guilt) and PA (Joviality, Self-Assurance) relative to restrictive eating...
November 28, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27890795/inhibition-of-histone-lysine-acetyltransferase-activity-kills-cocl2-treated-and-hypoxia-exposed-gastric-cancer-cells-and-reduces-their-invasiveness
#4
Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixit, Niranjan Rout, Shivaram P Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T Smoot, Mahadeva M Swamy, Tapas K Kundu, Sheila E Crowe, Asima Bhattacharyya
Hypoxia enhances immortality and metastatic properties of solid tumors. Deregulation of histone acetylation has been associated with several metastatic cancers but its effect on hypoxic responses of cancer cells is not known. This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl2), a hypoxia-mimetic chemical, or 1% O2. Here, we show that CTK7A-induced hydrogen peroxide (H2O2) generation in CoCl2-exposed and invasive gastric cancer cells (GCCs) leads to p38 MAPK-mediated Noxa expression and thereafter, mitochondrial apoptotic events...
November 23, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27890027/a-longitudinal-description-of-emergency-medical-services-professionals-by-race-ethnicity
#5
Remle P Crowe, Roger Levine, Jennifer J Eggerichs, Melissa A Bentley
OBJECTIVE: The objective of this paper was to compare demographics, employment variables, satisfaction, and motivation for entering the field of Emergency Medical Services (EMS) between members of under-represented races/ethnicities and members of the majority group. METHODS: A cohort of nationally certified EMS professionals was followed for 10 years through annual surveys; however, race/ethnicity was only available for 9 years (2000-2008). Descriptive statistics and 95% confidence intervals (CIs) were calculated and significance was determined by lack of CI overlap...
November 28, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27886785/approaches-to-sustainable-capacity-building-for-cardiovascular-disease-care-in-kenya
#6
REVIEW
Felix A Barasa, Rajesh Vedanthan, Sonak D Pastakia, Susie J Crowe, Wilson Aruasa, Wilson K Sugut, Russ White, Elijah S Ogola, Gerald S Bloomfield, Eric J Velazquez
Cardiovascular diseases are approaching epidemic levels in Kenya and other low- and middle-income countries without accompanying effective preventive and therapeutic strategies. This is happening in the background of residual and emerging infections and other diseases of poverty, and increasing physical injuries from traffic accidents and noncommunicable diseases. Investments to create a skilled workforce and health care infrastructure are needed. Improving diagnostic capacity, access to high-quality medications, health care, appropriate legislation, and proper coordination are key components to ensuring the reversal of the epidemic and a healthy citizenry...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27885883/college-students-stigmatization-of-people-with-mental-illness-familiarity-implicit-person-theory-and-attribution
#7
Amy E Lyndon, Allison Crowe, Karl L Wuensch, Susan L McCammon, Karen B Davis
BACKGROUND: Stigma associated with mental illness (MI) results in underutilization of mental health care. We must understand factors contributing to stigma to shape anti-stigma campaigns. AIMS: To investigate the factors influencing stigma in university students. METHOD: Undergraduate psychology students completed measures on causal attribution, stigma, social distance, implicit person theory (IPT), and familiarity. RESULTS: The hypothesis was partially supported; people who felt personality traits were unchangeable (i...
November 25, 2016: Journal of Mental Health
https://www.readbyqxmd.com/read/27884215/public-perception-of-emergency-medical-services-in-the-united-states
#8
Remle P Crowe, Roger Levine, Severo Rodriguez, Ashley D Larrimore, Ronald G Pirrallo
OBJECTIVE: The objective of this study was to assess the public's experience, expectations, and perceptions related to Emergency Medical Services (EMS). METHODS: A population-based telephone interview of adults in the United States was conducted. The survey instrument consisted of 112 items. Demographic variables including age, race, political beliefs, and household income were collected. Data collection was performed by trained interviewers from Kent State University's (Kent, Ohio USA)Social Research Laboratory...
November 25, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27884065/the-efficacy-of-2-formulations-of-botulinum-toxin-type-a-for-masseter-reduction-a-split-face-comparison-study
#9
Rungsima Wanitphakdeedecha, Chanida Ungaksornpairote, Arisa Kaewkes, Angkana Sathaworawong, Nittaya Lektrakul, Woraphong Manuskiatti
BACKGROUND: Botulinum toxin type A (BTA) is now extensively used to address cosmetic concerns. OnabotulinumtoxinA (ONA, Botox; Allergan Inc., Irvine, CA) received FDA approval for upper face rejuvenation, including glabella frown lines and crow's-feet lines. The other off-label uses for lower face conditions have been utilized for contouring purposes, especially masseter hypertrophy. Recently, a new Daewoong BTA, (Nabota, NBT, Daewoong Pharmaceutical, Seoul, Korea), was recently introduced...
November 25, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27881787/sensory-and-working-memory-representations-of-small-and-large-numerosities-in-the-crow-endbrain
#10
Helen M Ditz, Andreas Nieder
: Neurons in the avian nidopallium caudolaterale (NCL), an endbrain structure that originated independently from the mammalian neocortex, process visual numerosities. To clarify the code for number in this anatomically distinct endbrain area in birds, neuronal responses to a broad range of numerosities were analyzed. We recorded single-neuron activity from the NCL of crows performing a delayed match-to-sample task with visual numerosities as discriminanda. The responses of >20% of randomly selected neurons were modulated significantly by numerosities ranging from one to 30 items...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881295/measuring-dose-from-radiotherapy-treatments-in-the-vicinity-of-a-cardiac-pacemaker
#11
Samuel C Peet, Rachael Wilks, Tanya Kairn, Scott B Crowe
This study investigated the dose absorbed by tissues surrounding artificial cardiac pacemakers during external beam radiotherapy procedures. The usefulness of out-of-field reference data, treatment planning systems, and skin dose measurements to estimate the dose in the vicinity of a pacemaker was also examined. Measurements were performed by installing a pacemaker onto an anthropomorphic phantom, and using radiochromic film and optically stimulated luminescence dosimeters to measure the dose in the vicinity of the device during the delivery of square fields and clinical treatment plans...
November 21, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27881204/the-longitudinal-emergency-medical-technician-emt-attributes-and-demographics-study-leads-the-first-10-years-and-a-look-at-public-perception-of-emergency-medical-services-ems
#12
Remle P Crowe, Melissa A Bentley, Roger Levine
Crowe RP , Bentley MA , Levine R . The Longitudinal Emergency Medical Technician (EMT) Attributes and Demographics Study (LEADS): the first 10 years and a look at public perception of Emergency Medical Services (EMS). Prehosp Disaster Med. 2016;31(Suppl. 1):s1-s6.
November 24, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27876975/detection-of-cryptosporidium-spp-in-free-ranging-animals-of-tehran-iran
#13
Mehran Mirzaghavami, Javid Sadraei, Mehdi Forouzandeh
Cryptosporidium is a world widely distributed parasite which comparatively has a high prevalence in developing countries. The zoonotic potential of some Cryptosporidium species has made the cryptosporidiosis a significant concern to physicians and veterinarians. The occurrence and zoonotic potential of Cryptosporidium species in probable reservoir hosts for man infections was determined by examining faeces of symptomatic and asymptomatic animals. The aim of this study is to screen the presence of Cryptosporidium in fecal sample of free ranging animals in Tehran using Ziehl-Neelsen staining method...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27874150/the-radiological-research-for-pelvis-asymmetry-of-unilateral-developmental-dysplasia-of-the-hip-in-adult
#14
Ya-Min Li, Jue-Hong Li, Bin Li, Jia-Xing Wang, Yun-Su Chen
To investigate whether adult patients with unilateral developmental dysplasia of the hip (UDDH) have pelvic asymmetry and what correlation existing between them. Methods: A total of 100 adult patients with UDDH were enrolled in the retrospective observational study in Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China, between January 2012 and February 2014. The anteroposterior pelvic radiographs were reviewed and the pelvic heights and ischium heights were measured and compared between the affected and non-affected sides to find out the relationship between the pelvic morphology and hip dysplasia...
December 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27872403/biomechanical-analysis-of-weighted-ball-exercises-for-baseball-pitchers
#15
Glenn S Fleisig, Alek Z Diffendaffer, Kyle T Aune, Brett Ivey, Walter A Laughlin
BACKGROUND: Weighted-ball throwing programs are commonly used in training baseball pitchers to increase ball velocity. The purpose of this study was to compare kinematics and kinetics among weighted-ball exercises with values from standard pitching (ie, pitching standard 5-oz baseballs from a mound). HYPOTHESIS: Ball and arm velocities would be greater with lighter balls and joint kinetics would be greater with heavier balls. STUDY DESIGN: Controlled laboratory study...
November 21, 2016: Sports Health
https://www.readbyqxmd.com/read/27867222/strong-between-site-variation-in-new-caledonian-crows-use-of-hook-tool-making-materials
#16
James J H St Clair, Barbara C Klump, Jessica E M van der Wal, Shoko Sugasawa, Christian Rutz
Functional tool use requires the selection of appropriate raw materials. New Caledonian crows Corvus moneduloides are known for their extraordinary tool-making behaviour, including the crafting of hooked stick tools from branched vegetation. We describe a surprisingly strong between-site difference in the plant materials used by wild crows to manufacture these tools: crows at one study site use branches of the non-native shrub Desmanthus virgatus, whereas only approximately 7 km away, birds apparently ignore this material in favour of the terminal twigs of an as-yet-unidentified tree species...
June 2016: Biological Journal of the Linnean Society
https://www.readbyqxmd.com/read/27864088/modality-invariant-audio-visual-association-coding-in-crow-endbrain-neurons
#17
Felix W Moll, Andreas Nieder
Single neuron activity in the corvid nidopallium caudolaterale (NCL), the supposed avian functional analog of the prefrontal cortex, represents associations of auditory with visual stimuli. This is of high adaptive value for songbirds that need to rely on audio-visual associations to communicate, find a mate or escape predators. However, it remains unclear whether NCL neurons can represent cross-modal associations in a modality invariant, abstract fashion. To dissociate between modality-dependent and modality-invariant NCL activity, we trained two crows to match auditory sample cues with visual test stimuli, and vice versa, across a temporal memory delay...
November 15, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27859487/an-empirical-test-of-the-interpersonal-theory-of-suicide-in-a-heterogeneous-eating-disorder-sample
#18
Emily M Pisetsky, Scott J Crow, Carol B Peterson
OBJECTIVE: The Interpersonal Theory of Suicide (IPTS) model has not been fully tested in a clinical eating disorder (ED) population. METHOD: Participants (N = 114) completed questionnaires assessing suicidal ideation (SI), suicide attempts (SA), and constructs of the IPTS. Logistic regressions determined whether thwarted belongingness and perceived burdensomeness were associated with lifetime SI. Among those who endorsed lifetime SI, logistic regressions were used to determine whether elements of the acquired capability for suicide (fearlessness about death and painful and provocative events) were associated with lifetime SA...
November 17, 2016: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27854211/n-terminal-%C3%AE-dystroglycan-%C3%AE-dg-n-a%C3%A2-potential-serum-biomarker-for-duchenne-muscular-dystrophy
#19
Kelly E Crowe, Guohong Shao, Kevin M Flanigan, Paul T Martin
BACKGROUND: Duchenne Muscular Dystrophy (DMD) is a severe, progressive, neuromuscular disorder of childhood. While a number of serum factors have been identified as potential biomarkers of DMD, none, as yet, are proteins within the dystrophin-associated glycoprotein (DAG) complex. OBJECTIVE: We have developed an immobilized serum ELISA assay to measure the expression of a constitutively cleaved and secreted component of the DAG complex, the N-terminal domain of α dystroglycan (αDG-N), and assayed relative expression in serum from muscular dystrophy patients and normal controls...
May 27, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27853622/tool-bending-in-new-caledonian-crows
#20
Christian Rutz, Shoko Sugasawa, Jessica E M van der Wal, Barbara C Klump, James J H St Clair
'Betty' the New Caledonian crow astonished the world when she 'spontaneously' bent straight pieces of garden wire into hooked foraging tools. Recent field experiments have revealed that tool bending is part of the species' natural behavioural repertoire, providing important context for interpreting Betty's iconic wire-bending feat. More generally, this discovery provides a compelling illustration of how natural history observations can inform laboratory-based research into the cognitive capacities of non-human animals...
August 2016: Royal Society Open Science
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