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https://www.readbyqxmd.com/read/28087229/disease-associated-mutations-identify-a-novel-region-in-human-sting-necessary-for-the-control-of-type-i-interferon-signaling
#1
Isabelle Melki, Yoann Rose, Carolina Uggenti, Lien Van Eyck, Marie-Louise Frémond, Naoki Kitabayashi, Gillian I Rice, Emma M Jenkinson, Anaïs Boulai, Nadia Jeremiah, Marco Gattorno, Sefano Volpi, Olivero Sacco, Suzanne W J Terheggen-Lagro, Harm A W M Tiddens, Isabelle Meyts, Marie-Anne Morren, Petra De Haes, Carine Wouters, Eric Legius, Anniek Corveleyn, Frederic Rieux-Laucat, Christine Bodemer, Isabelle Callebaut, Mathieu P Rodero, Yanick J Crow
BACKGROUND: Gain-of-function mutations in transmembrane protein 173 (TMEM173) encoding stimulator of interferon genes (STING) underlie a recently described type I interferonopathy called STING-associated vasculopathy with onset in infancy (SAVI). OBJECTIVES: We sought to define the molecular and cellular pathology relating to 3 individuals variably exhibiting the core features of the SAVI phenotype including systemic inflammation, destructive skin lesions, and interstitial lung disease...
January 3, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28077445/human-antiviral-protein-ifix-suppresses-viral-gene-expression-during-hsv-1-infection-and-is-counteracted-by-virus-induced-proteasomal-degradation
#2
Marni S Crow, Ileana M Cristea
The interferon inducible protein X (IFIX), a member of the PYHIN family, was recently recognized as an antiviral factor against infection with herpes simplex virus 1 (HSV-1). IFIX binds viral DNA upon infection and promotes antiviral cytokines expression. How IFIX exerts its host defense functions and whether it is inhibited by the virus remains unknown. Here, we integrated live cell microscopy, proteomics, IFIX domain characterization, and molecular virology to investigate IFIX regulation and antiviral functions during HSV-1 infection...
January 11, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28075436/gait-kinematic-deviations-in-patients-with-developmental-dysplasia-of-the-hip-treated-with-total-hip-arthroplasty
#3
Yong Nie, Ning Ning, Fuxing Pei, Bin Shen, Zongke Zhou, Zongming Li
Comprehensive gait analysis of patients with Crowe type II and III developmental dysplasia of the hip (DDH) after successful total hip arthroplasty (THA) is lacking in the literature. This study evaluated gait function in joint kinematics after unilateral and bilateral THA in patients with DDH. In addition, the effect of high cup position on gait function was investigated. A total of 16 unilateral and 15 bilateral cementless THA patients due to DDH and 10 healthy participants comprised the study population...
January 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28073051/older-peoples-strategies-for-coping-with-chronic-non-malignant-pain-a-qualitative-meta-synthesis
#4
REVIEW
Marie Crowe, Deborah Gillon, Jennifer Jordan, Cate McCall
BACKGROUND: There is evidence that chronic pain is not recognised or managed effectively in older people. It is important to examine how older people cope with this because of the impact it can have on their quality of life and mortality. It will also enable nurses to work with older people to support effective coping skills and provide information on other useful coping strategies. OBJECTIVES: To examine how older people cope with non-malignant chronic pain. DESIGN: This is a qualitative meta-synthesis using Confidence in the Evidence from Reviews of Qualitative Research developed by Grading of Recommendations Assessment Development and Evaluation working group to evaluate the strength of the evidence...
December 23, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28066896/parasite-excretory-secretory-products-and-their-effects-on-metabolic-syndrome
#5
Jenny Crowe, Felicity E Lumb, Margaret M Harnett, William Harnett
Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is associated with MetS and obesity. A dominant type 2/anti-inflammatory response is required for metabolic homeostasis within adipose tissue: during obesity, this response is replaced by infiltrating, inflammatory macrophages and T cells. Helminths and certain protozoan parasites are able to manipulate the host immune response towards a TH2 immune phenotype that is beneficial for their survival and there is emerging data that there is an inverse correlation between the incidence of MetS and helminth infections, suggesting that, as with autoimmune and allergic diseases, helminths may play a protective role against MetS disease...
January 9, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28064516/using-dominance-analysis-to-decompose-narcissism-and-its-relation-to-aggression-and-externalizing-outcomes
#6
Colin E Vize, Katherine L Collison, Michael L Crowe, W Keith Campbell, Joshua D Miller, Donald R Lynam
Research on narcissism has shown it to be multidimensional construct. As such, the relations the larger construct bear with certain outcomes may mask heterogeneity apparent at the more basic trait level. This article used the Five Factor Narcissism Inventory, a Five-Factor Model-based measure of narcissism that allows for multiple levels of analysis, to examine the relative importance of narcissistic traits in relation to aggression, externalizing behavior, and self-esteem outcomes in two independent samples...
January 1, 2017: Assessment
https://www.readbyqxmd.com/read/28062603/combining-qualitative-and-quantitative-operational-research-methods-to-inform-quality-improvement-in-pathways-that-span-multiple-settings
#7
Sonya Crowe, Katherine Brown, Jenifer Tregay, Jo Wray, Rachel Knowles, Deborah A Ridout, Catherine Bull, Martin Utley
BACKGROUND: Improving integration and continuity of care across sectors within resource constraints is a priority in many health systems. Qualitative operational research methods of problem structuring have been used to address quality improvement in services involving multiple sectors but not in combination with quantitative operational research methods that enable targeting of interventions according to patient risk. We aimed to combine these methods to augment and inform an improvement initiative concerning infants with congenital heart disease (CHD) whose complex care pathway spans multiple sectors...
January 6, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28060758/exosomes-as-mediators-of-platinum-resistance-in-ovarian-cancer
#8
Jennifer Crow, Safinur Atay, Samagya Banskota, Brittany Artale, Sarah Schmitt, Andrew K Godwin
Exosomes have been implicated in the cell-cell transfer of oncogenic proteins and genetic material. We speculated this may be one mechanism by which an intrinsically platinum-resistant population of epithelial ovarian cancer (EOC) cells imparts its influence on surrounding tumor cells. To explore this possibility we utilized a platinum-sensitive cell line, A2780 and exosomes derived from its resistant subclones, and an unselected, platinum-resistant EOC line, OVCAR10. A2780 cells demonstrate a ~2-fold increase in viability upon treatment with carboplatin when pre-exposed to exosomes from platinum-resistant cells as compared to controls...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057405/genetic-variants-associated-with-skin-aging-in-the-chinese-han-population
#9
Wenshan Gao, Jingze Tan, Anke Hüls, Anan Ding, Yu Liu, Mary S Matsui, Andrea Vierkötter, Jean Krutmann, Tamara Schikowski, Li Jin, Sijia Wang
BACKGROUND: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. OBJECTIVE: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. METHODS: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort...
December 22, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28056712/neonatal-head-and-torso-vibration-exposure-during-inter-hospital-transfer
#10
Laurence Blaxter, Mildrid Yeo, Donal McNally, John Crowe, Caroline Henry, Sarah Hill, Neil Mansfield, Andrew Leslie, Don Sharkey
Inter-hospital transport of premature infants is increasingly common, given the centralisation of neonatal intensive care. However, it is known to be associated with anomalously increased morbidity, most notably brain injury, and with increased mortality from multifactorial causes. Surprisingly, there have been relatively few previous studies investigating the levels of mechanical shock and vibration hazard present during this vehicular transport pathway. Using a custom inertial datalogger, and analysis software, we quantify vibration and linear head acceleration...
December 1, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28056453/reduction-of-motion-artifacts-and-noise-using-independent-component-analysis-in-task-based-functional-mri-for-preoperative-planning-in-patients-with-brain-tumor
#11
E H Middlebrooks, C J Frost, I S Tuna, I M Schmalfuss, M Rahman, A Old Crow
BACKGROUND AND PURPOSE: Although it is a potentially powerful presurgical tool, fMRI can be fraught with artifacts, leading to interpretive errors, many of which are not fully accounted for in routinely applied correction methods. The purpose of this investigation was to evaluate the effects of data denoising by independent component analysis in patients undergoing preoperative evaluation for glioma resection compared with more routinely applied correction methods such as realignment or motion scrubbing...
November 10, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28053367/improving-health-care-quality-in-resource-poor-settings
#12
Bejoy Nambiar, Dougal S Hargreaves, Chelsea Morroni, Michelle Heys, Sonya Crowe, Christina Pagel, Felicity Fitzgerald, Susana Frazao Pinheiro, Delan Devakumar, Sue Mann, Monica Lakhanpaul, Martin Marshall, Tim Colbourn
No abstract text is available yet for this article.
January 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28052075/field-based-estimates-of-global-warming-potential-in-bioenergy-systems-of-hawaii-crop-choice-and-deficit-irrigation
#13
Meghan N Pawlowski, Susan E Crow, Manyowa N Meki, James R Kiniry, Andrew D Taylor, Richard Ogoshi, Adel Youkhana, Mae Nakahata
Replacing fossil fuel with biofuel is environmentally viable from a climate change perspective only if the net greenhouse gas (GHG) footprint of the system is reduced. The effects of replacing annual arable crops with perennial bioenergy feedstocks on net GHG production and soil carbon (C) stock are critical to the system-level balance. Here, we compared GHG flux, crop yield, root biomass, and soil C stock under two potential tropical, perennial grass biofuel feedstocks: conventional sugarcane and ratoon-harvested, zero-tillage napiergrass...
2017: PloS One
https://www.readbyqxmd.com/read/28050326/use-of-botulinum-neurotoxin-in-ophthalmology
#14
REVIEW
Emel Başar, Ceyhun Arıcı
Botulinum neurotoxin (BoNT) is the first biological toxin used in the treatment of ophthalmic diseases and to decrease skin wrinkles as an aesthetic agent. When used appropriately, it weakens the force of muscular contraction and/or inhibits glandular secretion. The most common areas for botulinum toxin treatment are the upper face, including the glabella, forehead, brows, and lateral canthal lines, or crow's feet. By relaxing the muscles causing wrinkles, non-permanent results may be achieved with its use...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28049495/the-link-between-the-west-african-ebola-outbreak-and-health-systems-in-guinea-liberia-and-sierra-leone-a-systematic-review
#15
REVIEW
Haitham Shoman, Emilie Karafillakis, Salman Rawaf
BACKGROUND: An Ebola outbreak started in December 2013 in Guinea and spread to Liberia and Sierra Leone in 2014. The health systems in place in the three countries lacked the infrastructure and the preparation to respond to the outbreak quickly and the World Health Organisation (WHO) declared a public health emergency of international concern on August 8 2014. OBJECTIVE: The aim of this study was to determine the effects of health systems' organisation and performance on the West African Ebola outbreak in Guinea, Liberia and Sierra Leone and lessons learned...
January 4, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28045891/susceptibility-and-antibody-response-of-the-laboratory-model-zebra-finch-taeniopygia-guttata-to-west-nile-virus
#16
Erik K Hofmeister, Melissa Lund, Valerie Shearn-Bochsler, Christopher N Balakrishnan
Since the introduction of West Nile virus (WNV) into North America in 1999 a number of passerine bird species have been found to play a role in the amplification of the virus. Arbovirus surveillance, observational studies and experimental studies have implicated passerine birds (songbirds, e.g., crows, American robins, house sparrows, and house finches) as significant reservoirs of WNV in North America, yet we lack a tractable passerine animal model for controlled studies of the virus. The zebra finch (Taeniopygia guttata) serves as a model system across a diversity of fields, and here we develop the zebra finch a songbird model for WNV...
2017: PloS One
https://www.readbyqxmd.com/read/28045305/using-online-crowdsourcing-platforms-for-data-collection-in-personality-disorder-research-the-example-of-amazon-s-mechanical-turk
#17
Joshua D Miller, Michael Crowe, Brandon Weiss, Jessica L Maples-Keller, Donald R Lynam
The use of crowdsourcing platforms such as Amazon's Mechanical Turk (MTurk) for data collection in the behavioral sciences has increased substantially in the past several years due in large part to (a) the ability to recruit large samples, (b) the inexpensiveness of data collection, (c) the speed of data collection, and (d) evidence that the data collected are, for the most part, of equal or better quality to that collected in undergraduate research pools. In this review, we first evaluate the strengths and potential limitations of this approach to data collection...
January 2017: Personality Disorders
https://www.readbyqxmd.com/read/28042944/comparison-of-serum-raav-serotype-specific-antibodies-in-patients-with-duchenne-muscular-dystrophy-becker-muscular-dystrophy-inclusion-body-myositis-or-gne-myopathy
#18
Deborah Zygmunt, Kelly E Crowe, Kevin Flanigan, Paul T Martin
Recombinant Adeno-associated virus (rAAV) is a commonly used gene therapy vector for the delivery of therapeutic transgenes in a variety of human diseases, but pre-existing serum antibodies to viral capsid proteins can greatly inhibit rAAV transduction of tissues. We have assayed serum from patients with Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (DMD), Inclusion Body Myositis (IBM), and GNE myopathy (GNE). These were compared to serum from otherwise normal human subjects to determine the extent of pre-existing serum antibodies to rAAVrh74, rAAV1, rAAV2, rAAV6, rAAV8 and rAAV9...
January 2, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28042107/the-genetic-basis-of-natural-variation-in-drosophila-diptera-drosophilidae-virgin-egg-retention
#19
Jamilla Akhund-Zade, Alan O Bergland, Sarah O Crowe, Robert L Unckless
Drosophila melanogaster is able to thrive in harsh northern climates through adaptations in life-history traits and physiological mechanisms that allow for survival through the winter. We examined the genetic basis of natural variation in one such trait, female virgin egg retention, which was previously shown to vary clinally and seasonally. To further our understanding of the genetic basis and evolution of virgin egg retention, we performed a genome-wide association study (GWAS) using the previously sequenced Drosophila Genetic Reference Panel (DGRP) mapping population...
December 31, 2016: Journal of Insect Science
https://www.readbyqxmd.com/read/28042059/operationalizing-the-measuring-what-matters-spirituality-quality-metric-in-a-population-of-hospitalized-critically-ill-patients-and-their-family-members
#20
Rebecca A Aslakson, Josephine Kweku, Malonnie Kinnison, Sarabdeep Singh, Thomas Y Crowe
CONTEXT: Measuring What Matters (MWM) quality indicators support measurement of the percentage of patients who have spiritual discussions, if desired. OBJECTIVES: To 1) determine the ease of, and barriers to, prospectively collecting MWM spirituality quality measure data and 2) further explore the importance of spirituality in a seriously ill, hospitalized population of critically ill patients and their family members. METHODS: Electronic medical record (EMR) review and cross-sectional survey of ICU patients and their family members from October-December 2015...
December 29, 2016: Journal of Pain and Symptom Management
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