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https://www.readbyqxmd.com/read/29166238/shiga-toxin-producing-e-coli-infections-associated-with-flour
#1
Samuel J Crowe, Lyndsay Bottichio, Lauren N Shade, Brooke M Whitney, Nereida Corral, Beth Melius, Katherine D Arends, Danielle Donovan, Jolianne Stone, Krisandra Allen, Jessica Rosner, Jennifer Beal, Laura Whitlock, Anna Blackstock, June Wetherington, Lisa A Newberry, Morgan N Schroeder, Darlene Wagner, Eija Trees, Stelios Viazis, Matthew E Wise, Karen P Neil
Background In 2016, a multijurisdictional team investigated an outbreak of Shiga toxin-producing Escherichia coli (STEC) serogroup O121 and O26 infections linked to contaminated flour from a large domestic producer. Methods A case was defined as infection with an outbreak strain in which illness onset was between December 21, 2015, and September 5, 2016. To identify exposures associated with the outbreak, outbreak cases were compared with non-STEC enteric illness cases, matched according to age group, sex, and state of residence...
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29160112/the-human-right-to-communicate-and-our-need-to-listen-learning-from-people-with-a-history-of-childhood-communication-disorder
#2
Jane McCormack, Elise Baker, Kathryn Crowe
PURPOSE: In 2013, the Australian Government Senate formed a committee for inquiry and report into the prevalence of speech, language, and communication disorders and speech pathology services in Australia. Submissions were sought from individuals and organisations. In this paper, submissions made by individuals with a history of childhood communication disorder were examined to explore their life experiences and the impact on their lives when the right to communicate could not be enacted...
November 21, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29156090/a-case-control-study-the-association-of-serum-paraoxonase-1-activity-and-concentration-with-the-development-of-type-2-diabetes-mellitus
#3
J Allen Crow, Edward C Meek, Robert W Wills, Janice E Chambers
BACKGROUND: A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS: Serum samples and clinical data collected and stored at different time points over a 20 year interval in the Air Force Health Study were analyzed. PON1 activity and concentration and C-reactive protein (CRP) concentration in samples from the same individuals 20 years apart were compared using a paired t test (n=159)...
November 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29155060/controlling-cell-free-metabolism-through-physiochemical-perturbations
#4
Ashty S Karim, Jacob T Heggestad, Samantha A Crowe, Michael C Jewett
Building biosynthetic pathways and engineering metabolic reactions in cells can be time-consuming due to complexities in cellular metabolism. These complexities often convolute the combinatorial testing of biosynthetic pathway designs needed to define an optimal biosynthetic system. To simplify the optimization of biosynthetic systems, we recently reported a new cell-free framework for pathway construction and testing. In this framework, multiple crude-cell extracts are selectively enriched with individual pathway enzymes, which are then mixed to construct full biosynthetic pathways on the time scale of a day...
November 15, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29154697/rate-of-subtalar-joint-arthrodesis-after-retrograde-tibiotalocalcaneal-arthrodesis-with-intramedullary-nail-fixation-evaluation-of-the-rain-database
#5
Michael Dujela, Christopher F Hyer, Gregory C Berlet
BACKGROUND: Hindfoot arthritis or significant deformity involving the ankle and subtalar joint (STJ) is a disabling condition with few salvage options. Many surgeons note a decreased STJ fusion rate compared with ankle union when a retrograde nail construct is used. The purpose of this study was to report the STJ fusion rate of tibiotalocalcaneal (TTC) arthrodesis with retrograde nail. METHODS: A chart and radiographic review was performed. TTC fusions performed in patients with osteoarthritis, posttraumatic arthritis, or deformity correction with retrograde nail fixation were included...
November 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29154483/evaluating-the-effectiveness-of-mental-health-nursing-interventions
#6
EDITORIAL
Marie Crowe
While acknowledging that not all that we do as mental health nurses is quantifiable and much of the art of our practice defies measurement, it is important to consider whether what we do is effective for service users on their journey to recovery. The evaluation of what we do is important for the survival of mental health nursing as a profession and for ensuring that the interventions we provide are useful for service users and their families. We are long past the days of doing things just because that is what has always been done and we are moving on from an emphasis on nurse-focussed research...
November 20, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29153506/role-of-non-local-interactions-between-cdr-loops-in-binding-affinity-of-mr78-antibody-to-marburg-virus-glycoprotein
#7
Amandeep K Sangha, Jinhui Dong, Lauren Williamson, Takao Hashiguchi, Erica Ollmann Saphire, James E Crowe, Jens Meiler
An atomic-detail model of the Marburg virus glycoprotein in complex with a neutralizing human monoclonal antibody designated MR78 was constructed using Phenix.Rosetta starting from a 3.6Å crystallographic density map. The Asp at T6 in the HCDR3's bulged torso cannot form the canonical salt bridge as position T2 lacks an Arg or Lys residue. It instead engages in a hydrogen bond interaction with a Tyr contributed by the HCDR1 loop. This inter-CDR loop interaction stabilizes the bulged conformation needed for binding to the viral glycoprotein: a Tyr to Phe mutant displays a binding affinity reduced by a factor of at least 10...
November 14, 2017: Structure
https://www.readbyqxmd.com/read/29148125/understanding-the-factors-which-promote-registered-nurses-intent-to-stay-in-critical-care-and-emergency-areas
#8
Mary Van Osch, Kathy Scarborough, Sarah Crowe, Angela C Wolff, Sheryl Reimer-Kirkham
BACKGROUND: Turnover among registered nurses (herein referred to as nurses) working in specialty areas of practice can result in a range of negative outcomes. The retention of specialty nurses at the unit level has important implications for hospital and health systems. These implications include lost knowledge and experience which may in turn impact staff performance levels, patient outcomes, hiring, orientating, development of clinical competence and other aspects of organizational performance...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29131787/mary-crow-leader-in-research-on-systemic-lupus-erythematosus
#9
Rita Rubin
No abstract text is available yet for this article.
October 7, 2017: Lancet
https://www.readbyqxmd.com/read/29129617/computed-tomographic-evaluation-of-bone-stock-in-patients-with-crowe-type-iii-developmental-dysplasia-of-the-hip-implications-for-guiding-acetabular-component-placement-using-the-high-hip-center-technique
#10
Bo Liu, Yu-Hang Gao, Lu Ding, Shu-Qiang Li, Jian-Guo Liu, Xin Qi
BACKGROUND: We evaluated acetabular cup coverage (CC) and rim contact (RC) to evaluate the bone stock above the acetabulum for guiding acetabular component placement using the high hip center technique in patients with Crowe type III developmental dysplasia of the hip. METHODS: Using hip computed tomography and image processing software, pelvises were reconstructed digitally in 20 hips with Crowe type III developmental dysplasia of the hip. Mimicked cup was placed with anteversion angles of 0° (group I), 5° (group II), and 10° (group III) respectively...
October 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29128976/neurons-in-the-crow-nidopallium-caudolaterale-encode-varying-durations-of-visual-working-memory-periods
#11
Konstantin Hartmann, Lena Veit, Andreas Nieder
Adaptive sequential behaviors rely on the bridging and integration of temporally separate information for the realization of prospective goals. Corvids' remarkable behavioral flexibility is thought to depend on the workings of the nidopallium caudolaterale (NCL), a high-level avian associative forebrain area. We trained carrion crows to remember visual items for three alternating delay durations in a delayed match-to-sample task and recorded single-unit activity from the NCL. Sample-selective delay activity, a correlate of visual working memory, was maintained throughout different working memory durations...
November 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29123031/structure-function-characterization-of-three-human-antibodies-targeting-the-vaccinia-virus-adhesion-molecule-d8
#12
Michael H Matho, Andrew Schlossman, Iuliia M Gilchuk, Greg Miller, Zbigniew Mikulski, Matthias Hupfer, Jing Wang, Aruna Bitra, Xianghzi Meng, Yan Xiang, Tom Kaever, Tzanko Doukov, Klaus Ley, Shane Crotty, Bjoern Peters, Linda C Hsieh-Wilson, James E Crowe, Dirk M Zajonc
Vaccinia virus (VACV) envelope protein D8 is one of three glycosaminoglycan adhesion molecules and binds to the linear polysaccharide chondroitin sulfate (CS). D8 is also a target for neutralizing antibody responses that are elicited by the smallpox vaccine, which has enabled the first eradication of a human viral pathogen and is a useful model for studying antibody responses. However, to date, VACV epitopes targeted by human antibodies have not been characterized at atomic resolution. Here, we characterized the binding properties of several human anti-D8 antibodies and determined the crystal structures of three VACV-MAb variants, VACV-66, VACV-138, and VACV-304, separately bound to D8...
November 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29117864/correction-to-ideas-actors-and-institutions-lessons-from-south-australian-health-in-all-policies-on-what-encourages-other-sectors-involvement
#13
Fran Baum, Toni Delany-Crowe, Colin MacDougall, Angela Lawless, Helen van Eyk, Carmel Williams
After publication of the article [1], it has been brought to our attention that Table 1 has been formatted poorly in the original version so that the columns are not aligned with their corresponding information. The correct version of the table is presented below. The original version of the article has now been revised.
November 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29113290/telomere-dna-damage-signaling-regulates-cancer-stem-cell-evolution-epithelial-mesenchymal-transition-and-metastasis
#14
Angelica M Lagunas, Jianchun Wu, David L Crowe
Chromosome ends are protected by telomeres that prevent DNA damage response and degradation. When telomeres become critically short, the DNA damage response is activated at chromosome ends which induces cellular senescence or apoptosis. Telomeres are protected by the double stranded DNA binding protein TRF2 and maintained by telomerase or a recombination based mechanism known as alternative lengthening of telomeres (ALT). Telomerase is expressed in the basal layer of the epidermis, and stem cells in epidermis have longer telomeres than proliferating populations...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111200/quality-of-life-psychological-functioning-and-treatment-satisfaction-of-men-who-have-undergone-penile-prosthesis-surgery-following-robot-assisted-radical-prostatectomy
#15
Brindha Pillay, Daniel Moon, Christopher Love, Denny Meyer, Emma Ferguson, Helen Crowe, Nicholas Howard, Sarah Mann, Addie Wootten
BACKGROUND: Penile prosthesis surgery is last-line treatment to regaining erectile function after radical prostatectomy (RP) for localized prostate cancer. AIMS: To assess quality of life, psychological functioning, and treatment satisfaction of men who underwent penile implantation after RP; the psychosocial correlates of treatment satisfaction and sexual function after surgery; and the relation between patients' and partners' ratings of treatment satisfaction...
October 27, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29110572/tracheostomy-as-a-comfort-measure-in-children-with-life-limiting-conditions
#16
Valerie Marshall, Francesca Holt, Suzanne Crowe
Palliative care for children who can expect only a short life has expanded over the last decade. Greater understanding of the measures required to ensure comfort and acceptable quality of life within the critical care environment has grown in tandem. Some more invasive interventions may be considered a "step too far" by some practitioners, including feeding gastrostomy, contracture release, and tracheostomy. Tracheostomy can facilitate a number of measures, which may enhance the brief life of the child and their family...
January 1, 2017: Journal of Palliative Care
https://www.readbyqxmd.com/read/29109272/structure-and-mechanotransmission-mechanism-of-the-macb-abc-transporter-superfamily
#17
Allister Crow, Nicholas P Greene, Elise Kaplan, Vassilis Koronakis
MacB is an ABC transporter that collaborates with the MacA adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the bacterial cell. Here we present the structure of ATP-bound MacB and reveal precise molecular details of its mechanism. The MacB transmembrane domain lacks a central cavity through which substrates could be passed, but instead conveys conformational changes from one side of the membrane to the other, a process we term mechanotransmission. Comparison of ATP-bound and nucleotide-free states reveals how reversible dimerization of the nucleotide binding domains drives opening and closing of the MacB periplasmic domains via concerted movements of the second transmembrane segment and major coupling helix...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29107984/treatment-with-proteasome-inhibitor-bortezomib-decreases-organic-anion-transporting-polypeptide-oatp-1b3-mediated-transport-in-a-substrate-dependent-manner
#18
Khondoker Alam, Taleah Farasyn, Alexandra Crowe, Kai Ding, Wei Yue
OATP1B1 and OATP1B3 mediate hepatic uptake of many drugs (e.g., statins) and can mediate transporter-mediated drug-drug-interactions (DDIs). Bortezomib is the first-in-class proteasome inhibitor drug approved by the U. S. Food and Drug Administration for the treatment of multiple myeloma. The potential of bortezomib to cause OATP-mediated DDIs has not been assessed. The current study investigated the involvement of the ubiquitin-proteasome system (UPS) in OATP1B1 and OATP1B3 degradation and determined the effects of proteasome inhibitors on OATP1B1- and OATP1B3-mediated transport...
2017: PloS One
https://www.readbyqxmd.com/read/29081434/entitled-to-addiction-pharmaceuticals-race-and-america-s-first-drug-war
#19
David Herzberg
This article rethinks the formative decades of American drug wars through a social history of addiction to pharmaceutical narcotics, sedatives, and stimulants in the first half of the twentieth century. It argues, first, that addiction to pharmaceutical drugs is no recent aberration; it has historically been more extensive than "street" or illicit drug use. Second, it argues that access to psychoactive pharmaceuticals was a problematic social entitlement constructed as distinctively medical amid the racialized reforms of the Progressive Era...
2017: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/29081331/immediate-and-delayed-neuropsychological-effects-of-carbon-monoxide-poisoning-a-meta-analysis
#20
Stephanie Watt, Catherine E Prado, Simon F Crowe
BACKGROUND: Carbon monoxide (CO) poisoning is the leading cause of accidental poisoning worldwide. This study undertook a meta-analysis to examine differences in neuropsychological functioning in patients with CO poisoning as compared to healthy controls, and examined the longer-term neuropsychological effects of CO poisoning. METHODS: Studies performed between the years 1995 and 2016 were identified through a search of the electronic databases Medline and PsycInfo...
October 30, 2017: Journal of the International Neuropsychological Society: JINS
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