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https://www.readbyqxmd.com/read/29330183/campylobacter-jejuni-colonization-in-the-crow-gut-involves-high-deletion-within-the-cytolethal-distending-toxin-gene-cluster
#1
Keya Sen, Jingrang Lu, Piyali Mukherjee, Tanner Berglund, Eunice Varughese, Asish K Mukhopadhyay
Campylobacter spp. are major causes of gastroenteritis worldwide. The virulence potential of Campylobacter shed in crow feces obtained from a roost area in Bothell, Washington, was studied and compared with isolates from other parts of Washington, and from a different crow spp., 7000 miles away, in Kolkata, India. Campylobacter was isolated from 61% and 69 % of the fecal samples obtained from Washington and Kolkata, respectively and were confirmed to be C. jejuni The cytolethal distending toxin (CDT) gene cluster from these isolates revealed a truncated sequence of about 1400 bp...
January 12, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29326102/collectively-improving-our-teaching-attempting-biology-department-wide-professional-development-in-scientific-teaching
#2
Melinda T Owens, Gloriana Trujillo, Shannon B Seidel, Colin D Harrison, Katherine M Farrar, Hilary P Benton, J R Blair, Katharyn E Boyer, Jennifer L Breckler, Laura W Burrus, Dana T Byrd, Natalia Caporale, Edward J Carpenter, Yee-Hung M Chan, Joseph C Chen, Lily Chen, Linda H Chen, Diana S Chu, William P Cochlan, Robyn J Crook, Karen D Crow, José R de la Torre, Wilfred F Denetclaw, Lynne M Dowdy, Darleen Franklin, Megumi Fuse, Michael A Goldman, Brinda Govindan, Michael Green, Holly E Harris, Zheng-Hui He, Stephen B Ingalls, Peter Ingmire, Amber R B Johnson, Jonathan D Knight, Gretchen LeBuhn, Terrye L Light, Candace Low, Lance Lund, Leticia M Márquez-Magaña, Vanessa C Miller-Sims, Christopher A Moffatt, Heather Murdock, Gloria L Nusse, V Thomas Parker, Sally G Pasion, Robert Patterson, Pleuni S Pennings, Julio C Ramirez, Robert M Ramirez, Blake Riggs, Rori V Rohlfs, Joseph M Romeo, Barry S Rothman, Scott W Roy, Tatiane Russo-Tait, Ravinder N M Sehgal, Kevin A Simonin, Greg S Spicer, Jonathon H Stillman, Andrea Swei, Leslie C Tempe, Vance T Vredenburg, Steven L Weinstein, Andrew G Zink, Loretta A Kelley, Carmen R Domingo, Kimberly D Tanner
Many efforts to improve science teaching in higher education focus on a few faculty members at an institution at a time, with limited published evidence on attempts to engage faculty across entire departments. We created a long-term, department-wide collaborative professional development program, Biology Faculty Explorations in Scientific Teaching (Biology FEST). Across 3 years of Biology FEST, 89% of the department's faculty completed a weeklong scientific teaching institute, and 83% of eligible instructors participated in additional semester-long follow-up programs...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29325104/eukaryotic-translational-termination-efficiency-is-influenced-by-the-3-nucleotides-within-the-ribosomal-mrna-channel
#3
Andrew G Cridge, Caillan Crowe-McAuliffe, Suneeth F Mathew, Warren P Tate
When a stop codon is at the 80S ribosomal A site, there are six nucleotides (+4 to +9) downstream that are inferred to be occupying the mRNA channel. We examined the influence of these downstream nucleotides on translation termination success or failure in mammalian cells at the three stop codons. The expected hierarchy in the intrinsic fidelity of the stop codons (UAA>UAG>UGA) was observed, with highly influential effects on termination readthrough mediated by nucleotides at position +4 and position +8...
January 9, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29324485/bearing-witness-to-anger-and-loss
#4
Suzanne Crowe
No abstract text is available yet for this article.
January 12, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29324225/the-marburgvirus-neutralizing-human-monoclonal-antibody-mr191-targets-a-conserved-site-to-block-virus-receptor-binding
#5
Liam B King, Marnie L Fusco, Andrew I Flyak, Philipp A Ilinykh, Kai Huang, Bronwyn Gunn, Robert N Kirchdoerfer, Kathryn M Hastie, Amandeep K Sangha, Jens Meiler, Galit Alter, Alexander Bukreyev, James E Crowe, Erica Ollmann Saphire
Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%-90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in non-human primates when delivered several days after inoculation of a lethal marburgvirus dose. The detailed neutralization mechanism of MR191 remains outstanding. Here we present a 3.2 Å crystal structure of MR191 complexed with a trimeric marburgvirus surface glycoprotein (GP)...
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29323510/consensual-lay-profiles-of-narcissism-and-their-connection-to-the-five-factor-narcissism-inventory
#6
Joshua D Miller, Donald R Lynam, Lane Siedor, Michael Crowe, W Keith Campbell
Although there is evidence that experts agree on the traits that characterize narcissism, this agreement may be due, in part, to the influence of the operationalizations based on the American Psychiatric Association's series of Diagnostic and Statistical Manuals of Mental Disorders (American Psychiatric Association [APA], 1980, 1994, 2013). Because these trait descriptions are important in shaping conceptualizations and serving as empirical criteria for construct validation, we explored their generalizability...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29321918/reproductive-management-in-dairy-cows-the-future
#7
REVIEW
Mark A Crowe, Miel Hostens, Geert Opsomer
Background: Drivers of change in dairy herd health management include the significant increase in herd/farm size, quota removal (within Europe) and the increase in technologies to aid in dairy cow reproductive management. Main body: There are a number of key areas for improving fertility management these include: i) handling of substantial volumes of data, ii) genetic selection (including improved phenotypes for use in breeding programmes), iii) nutritional management (including transition cow management), iv) control of infectious disease, v) reproductive management (and automated systems to improve reproductive management), vi) ovulation / oestrous synchronisation, vii) rapid diagnostics of reproductive status, and viii) management of male fertility...
2018: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29321259/plasmacytoid-dendritic-cells-promote-systemic-sclerosis-with-a-key-role-for-tlr8
#8
Marie Dominique Ah Kioon, Claudio Tripodo, David Fernandez, Kyriakos A Kirou, Robert F Spiera, Mary K Crow, Jessica K Gordon, Franck J Barrat
Systemic sclerosis (SSc) is a multisystem life-threatening fibrosing disorder that lacks effective treatment. The link between the inflammation observed in organs such as the skin and profibrotic mechanisms is not well understood. The plasmacytoid dendritic cell (pDC) is a key cell type mediating Toll-like receptor (TLR)-induced inflammation in autoimmune disease patients, including lupus and skin diseases with interface dermatitis. However, the role of pDCs in fibrosis is less clear. We show that pDCs infiltrate the skin of SSc patients and are chronically activated, leading to secretion of interferon-α (IFN-α) and CXCL4, which are both hallmarks of the disease...
January 10, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29321244/silencing-carboxylesterase-1-in-human-thp-1-macrophages-perturbs-genes-regulated-by-pparg-rxr-and-rar-rxr-downregulation-of-cyp27a1-lxr%C3%AE-signaling
#9
Lee C Mangum, Xiang Hou, Abdolsamad Borazjani, Jung Hwa Lee, Matthew K Ross, J Allen Crow
Macrophage foam cells store excess cholesterol as cholesteryl esters, which need to be hydrolyzed for cholesterol efflux. We recently reported that silencing expression of carboxylesterase 1 (CES1) in human THP-1 macrophages (CES1KD macrophages) reduced cholesterol uptake and decreased expression of CD36 and scavenger receptor-A in cells loaded with acetylated low-density lipoprotein (acLDL). Here, we report that CES1KD macrophages exhibit reduced transcription of cytochrome P450 27A1 ( CYP27A1 ) in non-loaded and acLDL-loaded cells...
January 10, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29321238/an-open-label-trial-of-jak-1-2-blockade-in-progressive-ifih1-associated-neuroinflammation
#10
Kavitha Kothur, Sushil Bandodkar, Stephanie Chu, Louise Wienholt, Alexandra Johnson, Peter Barclay, Paul A Brogan, Gillian I Rice, Yanick J Crow, Russell C Dale
No abstract text is available yet for this article.
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29310536/cognitive-functioning-in-systemic-lupus-erythematosus-a-meta-analysis
#11
B Leslie, S F Crowe
Cognitive deficits are common in patients with systemic lupus erythematosus (SLE) regardless of overt neuropsychiatric involvement; however, a clear neuropsychological profile of SLE has not emerged. This study undertook a literature search of the PubMed, Scopus and Ovid (PsychINFO) databases for studies investigating cognitive alterations in SLE, using standardized neuropsychological (NP) measures. The data were analysed using meta-analytical procedures. The results support the observation that relative to healthy controls, SLE (regardless of overt neuropsychiatric involvement) is associated with statistically significant, small effect-sized deficits in visual attention, cognitive fluency, immediate visual memory and visual reasoning...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29304032/community-engaged-cumulative-risk-assessment-of-exposure-to-inorganic-well-water-contaminants-crow-reservation-montana
#12
Margaret J Eggers, John T Doyle, Myra J Lefthand, Sara L Young, Anita L Moore-Nall, Larry Kindness, Roberta Other Medicine, Timothy E Ford, Eric Dietrich, Albert E Parker, Joseph H Hoover, Anne K Camper
An estimated 11 million people in the US have home wells with unsafe levels of hazardous metals and nitrate. The national scope of the health risk from consuming this water has not been assessed as home wells are largely unregulated and data on well water treatment and consumption are lacking. Here, we assessed health risks from consumption of contaminated well water on the Crow Reservation by conducting a community-engaged, cumulative risk assessment. Well water testing, surveys and interviews were used to collect data on contaminant concentrations, water treatment methods, well water consumption, and well and septic system protection and maintenance practices...
January 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29304007/living-with-smoker-s-and-smoking-cessation-in-chinese-adult-smokers-cross-sectional-and-prospective-evidence-from-hong-kong-population-health-survey
#13
Zhi-Ming Mai, Sai-Yin Ho, Man-Ping Wang, Lai-Ming Ho, Tai-Hing Lam
Background: Results on the environmental influence on unassisted quitting are scarce. We investigated the associations of living with smoker(s) with quitting in Chinese adult smokers. Methods: We examined both cross-sectional and prospective data in the Hong Kong Population Health Survey recruited participants in 2003/04, and followed up to 2006. Unconditional logistic regression yielded adjusted odds ratios (AORs) of (i) planning to quit, (ii) ex-smoking (cross-sectional), and quitting (prospective) for living with smoker(s)...
January 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29301755/copper-64-labeled-daratumumab-as-a-pet-ct-imaging-tracer-for-multiple-myeloma
#14
Enrico Caserta, Junie Chea, Megan Minnix, Domenico Viola, Steven Vonderfecht, Paul Yazaki, Desiree Crow, Jihane Khalife, James F Sanchez, Joycelynne M Palmer, Susanta Hui, Nadia Carlesso, Jonathan Keats, Young Kim, Ralf Buettner, Guido Marcucci, Steven Rosen, John Shively, David Colcher, Amrita Krishnan, Flavia Pichiorri
As a growing number of patients with multiple myeloma (MM) respond to upfront therapies while eventually relapsing in a time frame that is often non-predictable, attention has increasingly focused on developing novel diagnostic criteria to also account for disease dissemination. Positron emission tomography/computed tomography (PET/CT) is often used as a non-invasive monitoring strategy to assess cancer cell dissemination, but because the uptake of the currently used radiotracer 18fluoro-deoxyglucose (18F-FDG) is a function of the metabolic activity of both malignant and non-malignant cells, results frequently lack sufficient specificity...
January 4, 2018: Blood
https://www.readbyqxmd.com/read/29291112/sound-attenuation-in-the-ear-of-domestic-chickens-gallus-gallus-domesticus-as-a-result-of-beak-opening
#15
Pieter G G Muyshondt, Raf Claes, Peter Aerts, Joris J J Dirckx
Because the quadrate and the eardrum are connected, the hypothesis was tested that birds attenuate the transmission of sound through their ears by opening the bill, which potentially serves as an additional protective mechanism for self-generated vocalizations. In domestic chickens, it was examined if a difference exists between hens and roosters, given the difference in vocalization capacity between the sexes. To test the hypothesis, vibrations of the columellar footplate were measured ex vivo with laser Doppler vibrometry (LDV) for closed and maximally opened beak conditions, with sounds introduced at the ear canal...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29282545/relationship-between-pb-and-cd-accumulations-in-house-crow-their-habitat-and-food-content-from-klang-area-peninsular-malaysia
#16
Mohammed Janaydeh, Ahmad Ismail, Hishamuddin Omar, Syaizwan Zahmir Zulkifli, Mohd Hair Bejo, Nor Azwady Abd Aziz
Heavy metal pollution has become a global concern due to accumulation in tissue and transferable effects to humans via the food chain. This study focused on monitoring the accumulation of cadmium (Cd) and lead (Pb) in surface soil and body content: bone, heart, brain, liver, lung, muscle, kidney, feathers, feces, and gizzard contents of house crow Corvus splendens in the Klang region, Malaysia. The results revealed the occurrence of Pb and Cd in all biological samples from house crows, food contents, and surface soil samples...
December 27, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29282076/the-consequences-of-ireland-s-culture-of-medical-migration
#17
Niamh Humphries, Sophie Crowe, Cian McDermott, Sara McAleese, Ruairi Brugha
BACKGROUND: In recent years, Ireland has experienced a large-scale, outward migration of doctors. This presents a challenge for national policy makers and workforce planners seeking to build a self-sufficient medical workforce that trains and retains enough doctors to meet demand. Although, traditionally, medical migration has been considered beneficial to the Irish health system, austerity has brought a greater level of uncertainty to the health system and, with it, a need to reappraise the professional culture of migration and its impact on the Irish health system...
December 28, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/29278961/comparison-of-the-clinical-efficacy-of-abobotulinumtoxin-a-abo-and-onabotulinumtoxin-a-ona-in-the-treatment-of-crow-s-feet-wrinkles-a-split-face-study
#18
Ahmed Shafik Elridy, Rania Gamal Eldin Zaki, Reham Fawzy Elshinawy
PURPOSE: Comparing the clinical efficacy of Abobotulinumtoxin A (ABO) and Onabotulinumtoxin A(ONA) using a dosing ratio of 2.5U:1.0U in the treatment of crow's feet wrinkles. SUBJECTS AND METHODS: A single-blinded, randomized, split-face study, included 40 subjects, with moderate-to-severe crow's feet wrinkles. Patients were subjected to a dose equivalence of (ABO):(ONA); 2.5:1.0 U. Post treatment evaluation was done on 7, 30, and 120 days, comparing: Time, Duration, and Degree of Improvement; Patients Satisfaction...
December 26, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29277310/mechanism-of-intranasal-drug-delivery-directly-to-the-brain
#19
REVIEW
Tyler P Crowe, M Heather West Greenlee, Anumantha G Kanthasamy, Walter H Hsu
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge is to administer drugs intranasally to noninvasively bypass the blood-brain barrier. The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves...
December 22, 2017: Life Sciences
https://www.readbyqxmd.com/read/29272971/examining-the-beneficial-effect-of-neuropsychological-assessment-on-adult-patient-outcomes-a-systematic-review
#20
Stephanie Watt, Simon F Crowe
OBJECTIVE: Neuropsychological assessment (NPA) addresses important aspects of diagnosis, prognosis, treatment, and rehabilitation planning. This review set out to determine the impact of NPA on the adult patient's outcome, by examining how and whether NPA influences diagnostic decision-making and surgical planning, how NPA can be used to predict patient outcome, and how clients, referrers, and significant others perceive the value of NPA. METHOD: Eligible studies were selected according to pre-defined selection criteria and accessed via the electronic databases Medline and PsycInfo...
December 22, 2017: Clinical Neuropsychologist
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