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https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#1
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
August 12, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28810060/society-leadership-and-diversity-hail-to-the-women
#2
Anna Lok, Carol A Burke, Sheila E Crowe, Karen L Woods
No abstract text is available yet for this article.
August 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28809385/society-leadership-and-diversity-hail-to-the-women
#3
Anna Lok, Carol A Burke, Sheila E Crowe, Karen L Woods
No abstract text is available yet for this article.
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28808192/classification-of-facial-wrinkles-among-chinese-women
#4
Jiechen Zhang, Wei Hou, Suying Feng, Xiangsheng Chen, Hongwei Wang
It is generally recognized that Caucasians and Asians have different skin aging features. The aim of this study was to develop a facial wrinkle grading scale for Chinese women. Standard photographs were taken of 242 Chinese women. Six sets of 0 to 9 wrinkle scales with reference photographs and descriptions were selected, including grading scales for resting and hyperkinetic crow's feet, frontalis lines, glabellar frown lines, and nasolabial folds. To identify the scale by objective quantitative measurement, skin surface measurements from the Visioscan(®) VC98 were used...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28806294/the-tissue-engineered-tendon-bone-interface-in-vitro-and-in-vivo-synergistic-effects-of-adipo-derived-stem-cells-platelet-rich-plasma-and-extracellular-matrix-hydrogel
#5
Rory McGoldrick, Arhana Chattopadhyay, Christopher Crowe, Grace Chiou, Kenneth Hui, Simon Farnebo, Christopher Davis, Anais Le Grand, Molly Jacobs, Hung Pham, James Chang
INTRODUCTION: Suboptimal healing of the tendon bone interface (TBI) remains an unsolved problem. One solution is a biocompatible tissue engineered construct that promotes augmented healing. We hypothesisze that 1.) the presence of Platelet Rich Plasma (PRP) and prolonged in vitro incubation produces tissue engineered tendon bone interface scaffolds with greater reseeding of viable Adipo-derived Stem Cells (ADSC) and 2.) when implanted with extracellular matrix hydrogel, constructs will display superior in vivo strength repair and biocompatibility...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28805082/veterans-transitioning-from-isolation-to-integration-a-look-at-veteran-service-dog-partnerships
#6
Terry K Crowe, Victoria Sánchez, Alyse Howard, Brenna Western, Stephanie Barger
BACKGROUND: This study explored the dynamics of veteran/service dog partnerships by gathering the perspectives of veterans with a history of post-traumatic stress disorder and/or traumatic brain injury. METHODS: Exploratory qualitative methods (focus groups and individual interviews) were used to investigate veteran/service dog relationships related to community involvement, family and friend relationships, self-care, work, and leisure. Nine male veterans, Paws, and Stripes program graduates participated...
August 13, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28803918/modeling-of-trex1-dependent-autoimmune-disease-using-human-stem-cells-highlights-l1-accumulation-as-a-source-of-neuroinflammation
#7
Charles A Thomas, Leon Tejwani, Cleber A Trujillo, Priscilla D Negraes, Roberto H Herai, Pinar Mesci, Angela Macia, Yanick J Crow, Alysson R Muotri
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated inflammatory response. Autoimmune diseases, including Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus, can arise when TREX1 function is compromised. AGS is a neuroinflammatory disorder with severe and persistent intellectual and physical problems. Here we generated a human AGS model that recapitulates disease-relevant phenotypes using pluripotent stem cells lacking TREX1...
August 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28802085/recovery-and-mood-disorders
#8
EDITORIAL
Marie Crowe
The discourse of recovery has been co-opted by and pervades many standards of mental health service delivery. I want to consider what this means for mood disorders in a clinical context in which the medical model is the primary approach to treatment. The core concept in recovery discourse is concerned with living well in the presence or absence of mental illness and the many losses that may come in its wake, such as isolation, poverty, unemployment, and discrimination (Mental Health Commission 2012). This article is protected by copyright...
August 12, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28802048/biology-gone-wild
#9
Diana Crow
No abstract text is available yet for this article.
August 10, 2017: Cell
https://www.readbyqxmd.com/read/28800894/examining-unanswered-questions-about-the-home-environment-and-childhood-obesity-disparities-using-an-incremental-mixed-methods-longitudinal-study-design-the-family-matters-study
#10
Jerica M Berge, Amanda Trofholz, Allan Tate, Maureen Beebe, Angela Fertig, Michael Miner, Scott Crow, Kathleen A Culhane-Pera, Shannon Pergament, Dianne Neumark-Sztainer
There are disparities in the prevalence of childhood obesity for children from low-income and minority households. Mixed-methods studies that examine home environments in an in-depth manner are needed to identify potential mechanisms driving childhood obesity disparities that have not been examined in prior research. The Family Matters study aims to identify risk and protective factors for childhood obesity in low-income and minority households through a two-phased incremental, mixed-methods, and longitudinal approach...
August 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28799905/principles-of-broad-and-potent-antiviral-human-antibodies-insights-for-vaccine-design
#11
REVIEW
James E Crowe
Antibodies are the principal immune effectors that mediate protection against reinfection following viral infection or vaccination. Robust techniques for human mAb isolation have been developed in the last decade. The study of human mAbs isolated from subjects with prior immunity has become a mainstay for rational structure-based, next-generation vaccine development. The plethora of detailed molecular and genetic studies coupling the structure of antigen-antibody complexes with their antiviral function has begun to reveal common principles of critical interactions on which we can build better vaccines and therapeutic antibodies...
August 9, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28798742/preservation-and-significance-of-extracellular-dna-in-ferruginous-sediments-from-lake-towuti-indonesia
#12
Aurèle Vuillemin, Fabian Horn, Mashal Alawi, Cynthia Henny, Dirk Wagner, Sean A Crowe, Jens Kallmeyer
Extracellular DNA is ubiquitous in soil and sediment and constitutes a dominant fraction of environmental DNA in aquatic systems. In theory, extracellular DNA is composed of genomic elements persisting at different degrees of preservation produced by processes occurring on land, in the water column and sediment. Extracellular DNA can be taken up as a nutrient source, excreted or degraded by microorganisms, or adsorbed onto mineral matrices, thus potentially preserving information from past environments. To test whether extracellular DNA records lacustrine conditions, we sequentially extracted extracellular and intracellular DNA from anoxic sediments of ferruginous Lake Towuti, Indonesia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28794638/an-analysis-of-journey-mapping-to-create-a-palliative-care-pathway-in-a-canadian-first-nations-community-implications-for-service-integration-and-policy-development
#13
Jessica Koski, Mary Lou Kelley, Shevaun Nadin, Maxine Crow, Holly Prince, Elaine C Wiersma, Christopher J Mushquash
Providing palliative care in Indigenous communities is of growing international interest. This study describes and analyzes a unique journey mapping process undertaken in a First Nations community in rural Canada. The goal of this participatory action research was to improve quality and access to palliative care at home by better integrating First Nations' health services and urban non-Indigenous health services. Four journey mapping workshops were conducted to create a care pathway which was implemented with 6 clients...
2017: Palliative Care
https://www.readbyqxmd.com/read/28792741/correction-to-ubiquitin-chain-enrichment-middle-down-mass-spectrometry-enables-characterization-of-branched-ubiquitin-chains-in-cellulo
#14
Sean O Crowe, Ambar S J B Rana, Kirandeep K Deol, Ying Ge, Eric R Strieter
No abstract text is available yet for this article.
August 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28783021/acoustic-environments-matter-synergistic-benefits-to-humans-and-ecological-communities
#15
REVIEW
Clinton D Francis, Peter Newman, B Derrick Taff, Crow White, Christopher A Monz, Mitchell Levenhagen, Alissa R Petrelli, Lauren C Abbott, Jennifer Newton, Shan Burson, Caren B Cooper, Kurt M Fristrup, Christopher J W McClure, Daniel Mennitt, Michael Giamellaro, Jesse R Barber
Protected areas are critical locations worldwide for biodiversity preservation and offer important opportunities for increasingly urbanized humans to experience nature. However, biodiversity preservation and visitor access are often at odds and creative solutions are needed to safeguard protected area natural resources in the face of high visitor use. Managing human impacts to natural soundscapes could serve as a powerful tool for resolving these conflicting objectives. Here, we review emerging research that demonstrates that the acoustic environment is critical to wildlife and that sounds shape the quality of nature-based experiences for humans...
August 3, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28766762/is-laxative-misuse-associated-with-binge-eating-examination-of-laxative-misuse-among-individuals-seeking-treatment-for-eating-disorders
#16
Roni Elran-Barak, Andrea B Goldschmidt, Scott J Crow, Carol B Peterson, Laura Hill, Ross D Crosby, James E Mitchell, Daniel Le Grange
OBJECTIVE: Our research focuses on laxative misuse, which has been understudied in previous eating disorders (ED) research, to understand its prevalence and correlates among individuals seeking ED treatment. We also test the association between laxative misuse and binge eating to examine the assumption that laxative misuse is intended to compensate for binge eating. METHOD: Participants were 2,295 ED treatment-seeking adults (29.5 ± 10.5) who self-reported their disordered eating behaviors on the Eating Disorder Questionnaire...
August 2, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28762303/beyond-phonosurgery-considerations-for-patient-reported-outcomes-and-speech-therapy-in-transgender-vocal-feminization
#17
Shane D Morrison, Christopher S Crowe, Vania Rashidi, Jonathan P Massie, Scott R Chaiet, David O Francis
No abstract text is available yet for this article.
August 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28762026/feasibility-of-3d-printed-air-slab-diode-caps-for-small-field-dosimetry
#18
Benjamin Perrett, Paul Charles, Tim Markwell, Tanya Kairn, Scott Crowe
Commercial diode detectors used for small field dosimetry introduce a field-size-dependent over-response relative to an ideal, water-equivalent dosimeter due to high density components in the body of the detector. An air gap above the detector introduces a field-size-dependent under-response, and can be used to offset the field-size-dependent detector over-response. Other groups have reported experimental validation of caps containing air gaps for use with several types of diodes in small fields. This paper examines two designs for 3D printed diode air caps for the stereotactic field diode (SFD)-a cap containing a sealed air cavity, and a cap with an air cavity at the face of the SFD...
July 31, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28761365/oral-hyaluronan-relieves-wrinkles-a-double-blinded-placebo-controlled-study-over-a-12-week-period
#19
Mariko Oe, Seigo Sakai, Hideto Yoshida, Nao Okado, Haruna Kaneda, Yasunobu Masuda, Osamu Urushibata
BACKGROUND: Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA. METHODS: The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28758093/effect-of-interactions-between-harvester-ants-on-forager-decisions
#20
Jacob D Davidson, Roxana P Arauco-Aliaga, Sam Crow, Deborah M Gordon, Mark S Goldman
Harvester ant colonies adjust their foraging activity to day-to-day changes in food availability and hour-to-hour changes in environmental conditions. This collective behavior is regulated through interactions, in the form of brief antennal contacts, between outgoing foragers and returning foragers with food. Here we consider how an ant, waiting in the entrance chamber just inside the nest entrance, uses its accumulated experience of interactions to decide whether to leave the nest to forage. Using videos of field observations, we tracked the interactions and foraging decisions of ants in the entrance chamber...
October 2016: Frontiers in Ecology and Evolution
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