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Praseeda Mol, Uday Kannegundla, Gourav Dey, Lathika Gopalakrishnan, Manjunath Dammalli, Manish Kumar, Arun H Patil, Marappa Basavaraju, Akhila Rao, Kerekoppa P Ramesha, Thottethodi Subrahmanya Keshava Prasad
Bovine milk is important for both veterinary medicine and human nutrition. Understanding the bovine milk proteome at different stages of lactation has therefore broad significance for integrative biology and clinical medicine as well. Indeed, different lactation stages have marked influence on the milk yield, milk constituents, and nourishment of the neonates. We performed a comparative proteome analysis of the bovine milk obtained at different stages of lactation from the Indian indigenous cattle Malnad Gidda (Bos indicus), a widely available breed...
March 2018: Omics: a Journal of Integrative Biology
Yu Mi Park, Min-A Kim, Hee Tae Jung, Hwa Jeong Kang, Hwa-Seung Yoo, In-Cheol Kang
We investigated the antiangiogenic effects of Lindera obtusiloba Blume (Hwangmaemok, HMM), which is a plant in the Lauraceae family that is commonly used to treat colds and gastritis. Moreover, given that a recent study reported the inhibitory effects of HMM extract on cancer metastasis, we hypothesized that HMM extract might possess and antiangiogenic function. Thus, this study was conducted to investigate the effects of HMM extract on endothelial cell proliferation, migration, and neovascularization in chick chorioallantoic membrane (CAM), and investigated the molecular mechanism of antiangiogenesis using a ProteoChip-based proteomics technology...
June 2017: Journal of Medicinal Food
Sun Eun Lee, Kerry J Schulze, Robert N Cole, Lee S F Wu, James D Yager, John Groopman, Parul Christian, Keith P West
Vitamin K (VK) is a fat-soluble vitamin whose deficiency disrupts coagulation and may disturb bone and cardiovascular health. However, the scale and systems affected by VK deficiency in pediatric populations remains unclear. We conducted a study of the plasma proteome of 500 Nepalese children 6-8 years of age (male/female ratio = 0.99) to identify proteins associated with VK status. We measured the concentrations of plasma lipids and protein induced by VK absence-II (PIVKA-II) and correlated relative abundance of proteins quantified by mass spectrometry with PIVKA-II...
April 2016: Omics: a Journal of Integrative Biology
Vural Özdemir, Eugene Kolker
Nutrition is central to sustenance of good health, not to mention its role as a cultural object that brings together or draws lines among societies. Undoubtedly, understanding the future paths of nutrition science in the current era of Big Data remains firmly on science, technology, and innovation strategy agendas around the world. Nutrigenomics, the confluence of nutrition science with genomics, brought about a new focus on and legitimacy for "variability science" (i.e., the study of mechanisms of person-to-person and population differences in response to food, and the ways in which food variably impacts the host, for example, nutrient-related disease outcomes)...
February 2016: Omics: a Journal of Integrative Biology
Sascha Sauer, Toni Luge
Nutrition is a basic component of life. Nowadays, human nutrition research focuses amongst others on health-related aspects of food ingredients and extracts, and on analyzing the outcomes of specific diets. Usually, food ingredients such as bioactive peptides come in complex matrices. Single compounds, multiple interactions thereof and the underlying food matrix can vary physiological response of the organism. Proteins and peptides derived from food and beverages can cause adverse allergic reactions but are in general required for multiple functions such as growth and homeostatic regulation...
March 2015: Proteomics
A V Vasil'ev, N É Sharanova
Nutrition is one of the most critical aspects of human health and longevity. The idea of balanced nutrition supposes adequate supply of energy, macro- and micronutrients and furthermore normal functioning of specific mechanisms of nutrition. Contemporary biochemistry based on high performance methods, which assume increasing biological information. Developing of proteomic and metabolomic methods gives an opportunity to investigation macro- and micronutrients mechanisms of action. This was an incitement to formation new directions in biochemistry of nutrition: nutriproteomics and nutrimetabolomics...
2013: Voprosy Pitaniia
Nicola Luigi Bragazzi
Food has societal, economic, medical and ethical implications, being fundamental for life. It plays an important role also in sports medicine, since a healthy diet is an important part of an athlete's training. Nutrigenomics and nutriproteomics are emerging as a result of a convergence of nutritional, genomics and proteomics knowledge strands in the postgenomics era. These fields of inquiry present an opportunity for the design of customized diets potentially able to counterbalance the extant obesity epidemic and remedy metabolic diseases, among others...
June 2013: Current Pharmacogenomics and Personalized Medicine
N E Sharanova, S N Kulakova, V A Baturina, I Yu Toropygin, E A Khriapova, A V Vasilyev, M M G Gapparov
We studied proteomic features of subcellular fractions from rat hepatocytes and intensity of enzymatic and non-enzymatic free radical oxidation depending on the type of dietary fat during adaptation of animals to modified nutrition. Our results illustrate the formation of specific nutriproteomes in the microsomal and cytosolic fractions of rat hepatocytes (measurement of the macro-component and micro-component composition of diet).
January 2013: Bulletin of Experimental Biology and Medicine
N É Sharanova, Z V Karagodina, S N Kulakova, É N Trushina, O K Mustafina, A V Vasil'ev
During research specific proteomic pools of subcellular fractions of rats hepatic cells typical for different states of ontogenesis were identified. Taurine supplementation during early ontogenesis leads to a production of a catalase in rats' microsomes, that may be an evidence of activation of antioxidant defense system. Majority of proteomic markers (C-type lectin, SH2B1, protein phosphatase-1), which was investigated during taurine supplement, are rather identify features of energy homeostasis, than common assessment of apoptosis or expression certain set of proteins...
2012: Voprosy Pitaniia
N E Sharanova, I Yu Toropygin, E V Khriapova, A V Vasilyev, M M G Gapparov
The proteomic features of blood plasma and subcellular fractions of rat hepatocytes were studied during long-term dietary consumption of coenzyme Q10 as the endogenous mediator of antioxidant and energy homeostasis in the cell. Long-term coenzyme Q10 consumption was followed by the formation of specific nutriproteomes of the microsomal and cytosolic fractions of rat hepatocytes.
November 2012: Bulletin of Experimental Biology and Medicine
Vijayalakshmi Ganesh, Navam S Hettiarachchy
Nutriproteomics is a nascent research arena, exploiting the dynamics of proteomic tools to characterize molecular and cellular changes in protein expression and function on a global level as well as judging the interaction of proteins with food nutrients. As nutrients are present in complex mixtures, the bioavailability and functions of each nutrient can be influenced by the presence of other nutrients/compounds and interactions. The first half of this review focuses on the techniques used as nutriproteomic tools for identification, quantification, characterization and analyses of proteins including, two-dimensional polyacrylamide electrophoresis, chromatography, mass spectrometry, microarray and other emerging technologies involving visual proteomics...
October 2012: Biochimica et Biophysica Acta
Sandra Sénéchal, Martin Kussmann
Nutrition refers to the process by which a living organism ingests and digests food and uses the nutrients therein for growth, tissue maintenance and all other functions essential to life. Food components interact with our body at molecular, cellular, organ and system level. Nutrients come in complex mixtures, in which the presence and concentration of single compounds as well as their interactions with other compounds and the food matrix influence their bioavailability and bioefficacy. Traditionally, nutrition research mainly concentrated on supplying nutrients of quality to nourish populations and on preventing specific nutrient deficiencies...
August 2011: Proceedings of the Nutrition Society
Vural Ozdemir, Jean Armengaud, Laurette Dubé, Ramy Karam Aziz, Bartha M Knoppers
No abstract text is available yet for this article.
December 1, 2010: Current Pharmacogenomics and Personalized Medicine
Neïla Hamza, Frédéric Silvestre, Mohamed Mhetli, Ines Ben Khemis, Marc Dieu, Martine Raes, Chantal Cahu, Patrick Kestemont
A comparative proteomic approach was used to assess the protein expression profile in the liver of 34days old pikeperch larvae fed from day 10 post hatching, with three isoproteic and isolipidic formulated diets varying by their phospholipid (PL) contents (% dry diet weight): 1.4% (PL1), 4.7% (PL5) and 9.5% (PL9). Using 2D-DIGE minimal labelling of liver extracts, we were able to show 56 protein spots with a differential intensity (p<0.05) depending on the dietary PL content. Among these spots, 11 proteins were unambiguously identified using nanoLC-MS/MS tandem mass spectrometry...
June 2010: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
Xuewu Zhang, Yeeleng Yap, Dong Wei, Gu Chen, Feng Chen
A key scientific objective of nutrition research is to determine the role of diet in metabolic regulation and to improve health. There are many new opportunities and challenges for the nutrition research in post-genome era. Novel omics technologies and bioinformatics tools offer enormous potential to investigate the complex relationship between nutrition and metabolism. An overview of omics technologies in nutrition research is presented in this paper, which focuses on recent applications of nutritranscriptomics, nutriproteomics and nutrimetabolomics in nutrition research...
March 2008: Biotechnology Advances
Florian J Schweigert
Nutritional proteomics or nutriproteomics is the application of proteomics methodology to nutrition-related research but also represents the interaction of bioactive food ingredients with proteins, whereby the interaction with proteins occurs in two basically specific ways. Firstly, the effect of nutrients on protein expression, which can be monitored by protein mapping, and secondly, the interaction of nutrients with proteins by post-translational modifications or small-molecule protein interactions. These interactions result in changes to the three-dimensional structure of such effected proteins...
2007: Annals of Nutrition & Metabolism
Werner G Bergen
The roles of proteins, carbohydrates, fats, and micronutrients in animal and human nutrition were broadly described during the late 18th and 19th centuries, and knowledge in protein nutrition evolved from work with all species. Although much of the fundamental and theoretical research in protein metabolism during the 20th century was conducted with laboratory animals, basic protein nutrition research in farm animals complemented those efforts and led to the development and use of new investigative methods (particularly in amino acid nutrition) as well as use of animal models in furthering the understanding of human protein metabolism...
March 2007: Journal of Nutrition
Stephen Barnes, Helen Kim
The study of whole patterns of changes in protein expression and their modifications, or proteomics, presents both technological advances as well as formidable challenges to biological researchers. Nutrition research and the food sciences in general will be strongly influenced by the new knowledge generated by the proteomics approach. This review examines the different aspects of proteomics technologies, while emphasizing the value of consideration of "traditional" aspects of protein separation. These include the choice of the cell, the subcellular fraction, and the isolation and purification of the relevant protein fraction (if known) by protein chromatographic procedures...
January 31, 2004: Journal of Biochemistry and Molecular Biology
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