keyword
https://read.qxmd.com/read/38540287/age-dependent-effects-of-oxytocin-and-oxytocin-receptor-antagonists-on-bladder-contractions-implications-for-the-treatment-of-overactive-bladder-syndrome
#21
JOURNAL ARTICLE
Masroor Badshah, Jibriil Ibrahim, Nguok Su, Penny Whiley, Ralf Middendorff, Michael Whittaker, Betty Exintaris
Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a profound impact on an individual's quality of life. The development of LUTS may be linked to the overexpression of oxytocin receptors (OXTRs) within the bladder detrusor muscle, resulting in increased baseline myogenic tone. Thus, it is hypothesised that targeting OXTRs within the bladder using oxytocin antagonists may attenuate myogenic tone within the bladder, thereby providing a new therapeutic avenue for treating OAB...
March 18, 2024: Biomedicines
https://read.qxmd.com/read/38540274/yap1-regulates-the-yap1-ar-psa-axis-through-autophagy-in-castration-resistant-prostate-cancer-and-mediates-t-cell-immune-and-inflammatory-cytokine-infiltration
#22
JOURNAL ARTICLE
Youzhi Wang, Ning Wu, Junbo Li, Diansheng Zhou, Jiaming Liang, Qian Cao, Zhaokai Guan, Yangyang Xu, Ning Jiang
The emergence of castration-resistant prostate cancer (CRPC) following androgen deprivation therapy (ADT) is associated with increased malignancy and limited treatment options. This study aims to investigate potential connections between immune cell infiltration and inflammatory cytokines with the YAP1/AR/PSA axis by exploring their interactions with autophagy. Our research reveals heightened levels of Yes-associated protein 1 (YAP1) expression in CRPC tissues compared with tissues from androgen-dependent prostate cancer (ADPC) and benign prostate hyperplasia (BPH)...
March 15, 2024: Biomedicines
https://read.qxmd.com/read/38540237/different-coactivator-recruitment-to-human-ppar%C3%AE-%C3%AE-%C3%AE-ligand-binding-domains-by-eight-ppar-agonists-to-treat-nonalcoholic-fatty-liver-disease
#23
JOURNAL ARTICLE
Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii
Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in their promoter regions. Ligand-bound PPAR/RXR complexes do not directly regulate transcription; instead, they recruit multiprotein coactivator complexes to specific genomic regulatory loci to cooperatively activate gene transcription. Several coactivators are expressed in a single cell; however, a ligand-bound PPAR can be associated with only one coactivator through a consensus LXXLL motif...
March 11, 2024: Biomedicines
https://read.qxmd.com/read/38540076/dietary-zn-deficiency-inhibits-cell-proliferation-via-the-gpr39-mediated-suppression-of-the-pi3k-akt-mtor-signaling-pathway-in-the-jejunum-of-broilers
#24
JOURNAL ARTICLE
Yangyang Hu, Ke Yang, Weiyun Zhang, Mengxiao Xue, Tingting Li, Shengchen Wang, Xiaoyan Cui, Liyang Zhang, Yun Hu, Xugang Luo
A prior investigation revealed that a lack of Zinc (Zn) could hinder intestinal cell proliferation in broiler chickens; however, the mechanisms responsible for this effect remain unclear. We aimed to investigate the possible mechanisms of dietary Zn deficiency in inhibiting the jejunal cell proliferation of broilers. For this study, a total of 112 chickens (21 days old) were randomly divided into two treatments (seven replicate cages per treatment, eight chickens per replicate cage): the control group (CON) and the Zn deficiency group...
March 21, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38538440/interplay-between-hormonal-and-mechanical-signals-in-mammary-morphodynamics
#25
JOURNAL ARTICLE
Alişya A Anlaş, Celeste M Nelson
Mammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.
March 26, 2024: Trends in Cell Biology
https://read.qxmd.com/read/38537932/tnf-receptor-2-signals-clear-cell-renal-carcinoma-proliferation-via-phosphorylated-4ebp1-and-mitochondrial-gene-translation
#26
JOURNAL ARTICLE
Rafia S Al-Lamki, Aviva M Tolkovsky, Mohammad Alawwami, WanHua Lu, Sarah F Field, Jun Wang, Jordan S Pober, John R Bradley
Clear cell renal cell carcinoma (ccRCC), a tubular epithelial malignancy, secretes tumor necrosis factor (TNF) which signals ccRCC cells in an autocrine manner via two cell surface receptors, TNFR1 and TNFR2, to activate shared and distinct signalling pathways. Selective ligation of TNFR2 was shown to drive cell cycle entry of malignant cells via a signalling pathway involving Etk, VEGFR2, PI3K, Akt, pSer727 -Stat3 and mTOR. In this study, phosphorylated-4EBP1 serine 65 (pSer65 -4EBP1) is identified as a downstream target of this TNFR2 signalling pathway...
March 25, 2024: American Journal of Pathology
https://read.qxmd.com/read/38537884/identification-of-a-chromatin-bound-err%C3%AE-interactome-network-in-mouse-liver
#27
JOURNAL ARTICLE
Charlotte Scholtes, Catherine Rosa Dufour, Emma Pleynet, Samaneh Kamyabiazar, Phillipe Hutton, Reeba Baby, Christina Guluzian, Vincent Giguère
OBJECTIVE: Estrogen-related-receptor α (ERRα) plays a critical role in the transcriptional regulation of cellular bioenergetics and metabolism, and perturbations in its activity have been associated with metabolic diseases. While several coactivators and corepressors of ERRα have been identified to date, a knowledge gap remains in understanding the extent to which ERRα cooperates with coregulators in the control of gene expression. Herein, we mapped the primary chromatin-bound ERRα interactome in mouse liver...
March 25, 2024: Molecular Metabolism
https://read.qxmd.com/read/38537697/epstein-barr-virus-suppresses-n-6-methyladenosine-modification-of-tlr9-to-promote-immune-evasion
#28
JOURNAL ARTICLE
Xiaoyue Zhang, Zhengshuo Li, Qiu Peng, Can Liu, Yangge Wu, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Xiang Zheng, Qun Yan, Jia Wang, Jian Ma
Epstein-Barr virus (EBV) is a human tumor virus associated with a variety of malignancies, including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas. N6 -methyladenosine (m6 A) modifications modulate a wide range of cellular processes and participate in the regulation of virus-host cell interactions. Here, we discovered that EBV infection downregulates Toll-like receptor 9 (TLR9) m6 A modification levels and thus inhibits TLR9 expression. TLR9 has multiple m6 A modification sites. Knockdown of METTL3, an m6 A "writer", decreases TLR9 protein expression by inhibiting its mRNA stability...
March 25, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38537407/molybdenum-and-cadmium-co-induce-apoptosis-and-ferroptosis-through-inhibiting-nrf2-signaling-pathway-in-duck-anas-platyrhyncha-testes
#29
JOURNAL ARTICLE
Jiamei Zhu, Xueyan Dai, Yan Wang, Ting Cui, Bingyan Huang, Dianyun Wang, Wenjing Pu, Caiying Zhang
Cadmium (Cd) and high molybdenum (Mo) are injurious to the body. Previous research has substantiated that Cd and Mo exposure caused testicular injury of ducks, but concrete mechanism is not fully clarified. To further survey the toxicity of co-exposure to Cd and Mo in testis, 40 healthy 8-day-old Shaoxing ducks (Anas platyrhyncha) were stochasticly distributed to 4 groups and raised with basic diet embracing Cd (4 mg/kg Cd) or Mo (100 mg/kg Mo) or both. At the 16th wk, testis tissues were gathered. The characteristic ultrastructural changes related to apoptosis and ferroptosis were observed in Mo or Cd or both groups...
March 13, 2024: Poultry Science
https://read.qxmd.com/read/38537216/unusual-renal-uptake-of-131i-mibg-in-a-young-hypertensive-with-renal-artery-stenosis
#30
JOURNAL ARTICLE
Agrawal Roopal, Malhotra Gaurav
A 10-year-old hypertensive girl underwent 131I-MIBG scan to rule out neural crest derived tumor. The whole-body images revealed diffuse intense tracer uptake in the right kidney, which persisted in 96-hour images as well. CT renal angiography revealed 90% to 95% right renal artery stenosis. Thereafter, she underwent baseline and angiotensin receptor blockade renal dynamic imaging, which revealed hemodynamically significant renal artery stenosis. Pattern of diffuse and intense 131I-MIBG uptake, albeit rare, still warrants further evaluation to rule out renal artery stenosis and investigate its hemodynamic significance for appropriate management...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#31
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536119/m6a-modification-promotes-emt-and-metastasis-of-castration-resistant-prostate-cancer-by-upregulating-nfib
#32
JOURNAL ARTICLE
Feng Shu, Hao Liu, Xiaohui Chen, Ye Liu, Jiangli Zhou, Lei Tang, Wanwei Cao, Shanshan Yang, Yili Long, Rongna Li, Hao Wang, Hongsheng Wang, Guanmin Jiang
The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased incidence of AR-negative castration-resistant prostate cancer (CRPC), limiting effective treatment and patient survival. A more comprehensive understanding of the molecular mechanisms supporting AR-negative CRPC could reveal therapeutic vulnerabilities to improve treatment. This study showed that the transcription factor nuclear factor I/B (NFIB) was upregulated in AR-negative CRPC patient tumors and cell lines and was positively associated with an epithelial-to-mesenchymal transition (EMT) phenotype...
March 27, 2024: Cancer Research
https://read.qxmd.com/read/38535924/plasma-concentrations-of-high-mobility-group-box-1-proteins-and-soluble-receptors-for-advanced-glycation-end-products-are-relevant-biomarkers-of-cognitive-impairment-in-alcohol-use-disorder-a-pilot-study
#33
JOURNAL ARTICLE
Fernando Rodríguez de Fonseca, Francisco Medina-Paz, Mira Sapozhnikov, Isaac Hurtado-Guerrero, Leticia Rubio, Stella Martín-de-Las-Heras, Nerea Requena-Ocaña, María Flores-López, María Del Mar Fernández-Arjona, Patricia Rivera, Antonia Serrano, Pedro Serrano, Sara C Zapico, Juan Suárez
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in the brain, activated by increased reactive oxygen/nitrogen species (ROS/RNS), advanced glycation end-products (AGEs) and high-mobility group box 1 protein (HMGB1). In a pilot study, we examine the potential clinical value of circulating biomarkers of oxidative stress including ROS/RNS, HMGB1, the soluble receptor for AGE (sRAGE), the brain biomarker of aging apolipoprotein D (ApoD), and the antioxidant regulator nuclear factor erythroid 2-related factor 2 (NRF2) as predictive indices for cognitive impairment (CI) in abstinent patients with AUD ( n = 25) compared to patients with established Alzheimer's disease (AD, n = 26) and control subjects ( n = 25)...
February 29, 2024: Toxics
https://read.qxmd.com/read/38535820/the-effects-of-t-2-toxin-deoxynivalenol-and-fumonisin-b1-on-oxidative-stress-related-genes-in-the-kidneys-of-laying-hens
#34
JOURNAL ARTICLE
Benjamin Kövesi, Szabina Kulcsár, Zsolt Ancsin, Márta Erdélyi, Erika Zándoki, Patrik Gömbös, Krisztián Balogh, Miklós Mézes
In the context of nephrotoxic risks associated with environmental contaminants, this study focused on the impact of mycotoxin exposure on the renal health of laying hens, with particular attention to oxidative stress pathways. Sixty laying hens were assigned to three groups-a control group (CON), a low-dose mycotoxin group (LOW), and a high-dose mycotoxin group (HIGH)-and monitored for 72 h. Mycotoxin contamination involved T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 at their EU-recommended levels (low mix) and at double doses (high mix)...
March 16, 2024: Toxins
https://read.qxmd.com/read/38535478/effect-of-ishige-okamurae-extract-on-osteoclastogenesis-in-vitro-and-in-vivo
#35
JOURNAL ARTICLE
Su-Hyeon Cho, Hyun-Soo Kim, Juhee Ahn, Bomi Ryu, Jun-Geon Jea, Kyubin Lee, Kyunghwan Kim, Ginnae Ahn, WonWoo Lee, Kyung-Min Choi, Kil-Nam Kim
We demonstrated the effect of Ishige okamurae extract (IOE) on the receptor activator of nuclear factor-κB ligand (RANKL)-promoted osteoclastogenesis in RAW 264.7 cells and confirmed that IOE inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and osteoclast differentiation. IOE inhibited protein expression of TRAP, metallopeptidase-9 (MMP-9), the calcitonin receptor (CTR), and cathepsin K (CTK). IOE treatment suppressed the expression of activated T cell cytoplasmic 1 and activator protein-1, thus controlling the expression of osteoclast-related factors...
March 20, 2024: Marine Drugs
https://read.qxmd.com/read/38535258/in-vitro-effects-of-weissella-cibaria-cmu-and-cms1-on-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-rankl-induced-osteoclast-differentiation
#36
JOURNAL ARTICLE
Geun-Yeong Park, Jeong-Ae Park, Mi-Sun Kang
Excessive osteoclast activity can promote periodontitis-associated bone destruction. The inhibitory mechanisms of Weissella cibaria strains CMU and CMS1 against periodontitis have not yet been fully elucidated. In this study, we aimed to investigate whether heat-killed (HK) W. cibaria CMU and CMS1 or their respective cell-free supernatants (CFSs) inhibit osteoclast differentiation and bone resorption in response to receptor activator of nuclear factor kappa-B ligand (RANKL)-treated RAW 264.7 cells. TRAP (tartrate-resistant acid phosphatase) staining and bone resorption assays revealed that both HK bacteria and CFSs significantly suppressed the number of TRAP-positive cells, TRAP activity, and bone pit formation compared to the RANKL-treated control ( p < 0...
March 8, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#37
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534461/estrogen-and-progesterone-receptors-are-dysregulated-at-the-bph-5-mouse-preeclamptic-like-maternal-fetal-interface
#38
JOURNAL ARTICLE
Viviane C L Gomes, Bryce M Gilbert, Carolina Bernal, Kassandra R Crissman, Jenny L Sones
The etiopathogenesis of preeclampsia, a leading hypertensive disorder of pregnancy, has been proposed to involve an abnormal circulating sex hormone profile and misexpression of placental estrogen and progesterone receptors (ER and PR, respectively). However, existing research is vastly confined to third trimester preeclamptic placentas. Consequently, the placental-uterine molecular crosstalk and the dynamic ER and PR expression pattern in the peri-conception period remain overlooked. Herein, our goal was to use the BPH/5 mouse to elucidate pre-pregnancy and early gestation Er and Pr dynamics in a preeclamptic-like uterus...
March 16, 2024: Biology
https://read.qxmd.com/read/38534340/mechanical-stress-induces-sodium-entry-and-osmoprotective-responses-in-murine-synovial-fibroblasts
#39
JOURNAL ARTICLE
Annemarie Proff, Ute Nazet, Agnes Schröder, Jonathan Jantsch
Osteoarthritis (OA) is a multifactorial disease depending on molecular, genetic, and environmental factors like mechanical strain. Next to the cartilage and the subchondral bone, OA also affects the synovium, which is critically involved in the maintenance of joint homeostasis. As there is a correlation between the extracellular sodium content in the knee joint and OA, this study investigates the impact of sodium on OA-associated processes like inflammation and bone remodeling without and with mechanical loading in synovial fibroblasts...
March 13, 2024: Cells
https://read.qxmd.com/read/38533181/silencing-circatxn1-in-aging-nucleus-pulposus-cell-alleviates-intervertebral-disc-degeneration-via-correcting-progerin-mislocalization
#40
JOURNAL ARTICLE
Chao Yu, Jing Zhao, Feng Cheng, Jiangjie Chen, Jinyang Chen, Haibin Xu, Kesi Shi, Kaishun Xia, Siwen Ding, Kanbin Wang, Ronghao Wang, Yazhou Chen, Yi Li, Hao Li, Qixin Chen, Xiaohua Yu, Fangwei Shao, Chengzhen Liang, Fangcai Li
Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel circATXN1 highly accumulates in aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, and inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous nuclear ribonucleoprotein A2B1-mediated splicing circularization, promotes progerin translocation from the cell nucleus to the cytoplasm and inhibits the expression of insulin-like growth factor 1 receptor (IGF-1R)...
2024: Research: a science partner journal
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