keyword
MENU ▼
Read by QxMD icon Read
search

kidney and pancreas

keyword
https://www.readbyqxmd.com/read/28721827/melatonin-as-pleiotropic-molecule-with-therapeutic-potential-for-type-2-diabetes-and-cancer
#1
Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
The incidence both of diabetes, particularly type 2 (T2DM), and cancer is increasing worldwide, making these diseases growing global health problem along with increasing healthcare expenditures. The current therapeutic approach for the treatment of these multifactorial diseases is far from satisfactory. Therefore, there is still considerable interest in searching new therapeutic strategies with the use of both natural and synthetic compounds exhibiting higher efficiency and lower toxicity compared to medicines used currently in clinical practice...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28714549/increased-level-of-dna-damage-in-some-organs-of-obese-zucker-rats-by-%C3%AE-h2ax-analysis
#2
Alessia Azzarà, Anna Chiaramonte, Erika Filomeni, Barbara Pinto, Stefano Mazzoni, Simona Piaggi, Maria Angela Guzzardi, Fabrizio Bruschi, Patricia Iozzo, Roberto Scarpato
In a recent study, we showed that lymphocytes of obese Italian children/adolescents displayed levels of double strand breaks (DSB), assayed as serine 139-phosphorylated histone H2AX (γ-H2AX), about eightfold higher than normal weight controls, and that 30% of this damage-generated micronuclei. These findings suggested that obese children could be at increased risk of obesity-mediated cancer later in life. We therefore aimed to assess the level of γ-H2AX in a genetic animal model of obesity (Zucker rat) to identify a genotoxic/carcinogenic risk in some organs...
July 17, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28712376/grape-pomace-improves-performance-antioxidant-status-fecal-microbiota-and-meat-quality-of-piglets
#3
I Kafantaris, D Stagos, B Kotsampasi, A Hatzis, A Kypriotakis, K Gerasopoulos, S Makri, N Goutzourelas, C Mitsagga, I Giavasis, K Petrotos, S Kokkas, P Goulas, V Christodoulou, D Kouretas
In the present study, grape pomace (GP) was used as feed additive in the diet of weaned piglets in order to develop innovative feedstuffs and to investigate their potential beneficial effects on welfare, productivity and meat quality. For examining the antioxidant capacity of the experimental feeds, 24 piglets of 20 days old were assigned to two experimental groups receiving standard or experimental diet for 30 days. Blood and tissues collections were performed at four different time-points, 2, 20, 35 and 50 days post birth...
July 17, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28706746/acute-pancreatitis-and-rhabdomyolysis-with-acute-kidney-injury-following-multiple-wasp-stings
#4
Seo Hee Yang, Yeon Han Song, Tae Hoon Kim, Su Bin Kim, Sang Youb Han, Han-Seong Kim, Se Won Oh
Multiple wasp stings can induce multiple organ dysfunction by toxic reactions. However, acute pancreatitis is a rare manifestation in wasp sting injury. A 74-year-old woman visited the emergency department by anaphylactic shock because of multiple wasp stings. Acute kidney injury, rhabdomyolysis, hepatotoxicity, and coagulopathy were developed next day. Serum amylase and lipase were elevated and an abdominal computed tomography revealed an acute pancreatitis. Urine output was recovered after 16 days of oliguria (below 500 ml/day)...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28696022/outcomes-in-pancreas-transplantation-with-exocrine-drainage-through-a-duodenoduodenostomy-versus-duodenojejunostomy
#5
J P Lindahl, R Horneland, E Nordheim, A Hartmann, E M Aandahl, K Grzyb, H Haugaa, G Kjøsen, A Åsberg, T Jenssen
Until recently, pancreas transplantation has mostly been performed with exocrine drainage via duodenojejunostomy (DJ). Since 2012, DJ was substituted with duodenoduodenostomy (DD) in our hospital, allowing endoscopic access for biopsies. This study assessed safety profiles with DD versus DJ procedures, and clinical outcomes with the DD technique in pancreas transplantation. DD patients (n=117; 62 simultaneous pancreas and kidney [SPKDD ] and 55 pancreas transplantation alone [PTADD ] with median follow-up 2...
July 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28687168/evidence-based-anatomical-review-areas-derived-from-systematic-analysis-of-cases-from-a-radiological-departmental-discrepancy-meeting
#6
S C Chin, J R Weir-McCall, P M Yeap, R D White, M J Budak, G Duncan, T B Oliver, I A Zealley
AIM: To produce short checklists of specific anatomical review sites for different regions of the body based on the frequency of radiological errors reviewed at radiology discrepancy meetings, thereby creating "evidence-based" review areas for radiology reporting. MATERIALS AND METHODS: A single centre discrepancy database was retrospectively reviewed from a 5-year period. All errors were classified by type, modality, body system, and specific anatomical location...
July 4, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28684113/sericin-improves-heart-and-liver-mitochondrial-architecture-in-hypercholesterolaemic-rats-and-maintains-pancreatic-and-adrenal-cell-biosynthesis
#7
Sumate Ampawong, Duangnate Isarangkul, Pornanong Aramwit
Hypercholesterolaemia is well known to be associated with mitochondrial dysfunction, subsequently leading to multiple organ failure. Similar to other natural products, sericin is a candidate for adjunctive therapy in hyperlipidaemic conditions. However, the cholesterol-lowering mechanisms of sericin are multifactorial and controversial. Here, a high-cholesterol-fed rat model with or without sericin treatment was established using a dosage of 1,000mg/kg/day for 30 days. Blood lipid profiles, oxidative stress markers (superoxide dismutase, SOD; malondialdehyde, MDA; nuclear factor erythroid 2-related factor, Nrf-2), dysmorphic mitochondria in relation to fission (dynamin-related protein-1; Drp-1) and fusion (guanosine triphosphatase mutated in dominant optic atrophy; OPA-1) markers and biosynthetic markers (aquaporin, AQP-1; tubulin-4β, Tb4B) in the pancreas and adrenal gland were evaluated...
July 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28683901/in-hospital-cardiovascular-complications-after-pancreas-transplantation-in-the-united-states-from-2003-to-2012
#8
Jim Kim, Joshua Schulman-Marcus, Anthony C Watkins, Dmitriy N Feldman, Rajesh Swaminathan, Jun B Lee, Thangamani Muthukumar, David Serur, Luke Kim, Choli Hartono
Large database studies detailing the risk of perioperative cardiovascular complications after pancreas transplant has been limited, perhaps because these outcomes are not captured by transplant registries. Greater data on the incidence and risks of such outcomes could provide additional insight for referring physicians and inform potential recipients of their risk. We performed a serial, cross-sectional analysis of the National Inpatient Sample, the largest publicly available inpatient database in the United States, to assess for the risk of cardiovascular complications after pancreas transplants in the United States from 2003 to 2012 (n = 13,399)...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28681964/a-shared-comparison-of-diabetes-mellitus-and-neurodegenerative-disorders
#9
Mahmoud Morsi, Ahmed Maher, Ahmed Metwally, Omnia Abo-Elmagd, Dina Johar, Larry Bernstein
Diabetes Mellitus (DM) is one of the most common diseases in the world population, associated with obesity, pancreatic endocrine changes, cardiovascular disease, renal glomerular disease, cerebrovascular disease, peripheral neuropathy, neurodegenerative disease, retinal disease, sleep apnea, some of which are bundled into the metabolic syndrome. The main characteristic of this disease is hyperglycemia, and often with albuminuria. Nevertheless, the classic features, with ketoacidosis in the extreme, are only a first layer of description of this condition...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28672081/concurrent-biopsies-of-both-grafts-in-recipients-of-simultaneous-pancreas-and-kidney-demonstrates-high-rates-of-discordance-for-rejection-as-well-as-discordance-in-type-of-rejection
#10
Sandesh Parajuli, Emre Arpali, Brad C Astor, Arjang Djamali, Fahad Aziz, Robert R Redfield, Hans W Sollinger, Dixon Kaufman, Jon Odorico, Didier Mandelbrot
It is commonly assumed that in simultaneous kidney and pancreas (SPK) recipients, rejection of the two organs is concordant. As a result, concurrent biopsies of both organs are rarely performed and there are limited histological data on how often rejection is in fact discordant. We reviewed all SPK recipients transplanted at the University of Wisconsin between 01/01/2001 and 12/31/2016 that underwent biopsy of both organs. We included all patients whose biopsies were within 30 days. If patients were treated for rejection between biopsies, they were excluded if the biopsies were more than 4 days apart...
July 3, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28668647/toxicological-evaluation-of-the-aqueous-whole-plant-extract-of-aerva-lanata-l-juss-ex-schult-amaranthaceae
#11
Kayode S Omotoso, Flora R Aigbe, Olanrewaju A Salako, Micah C Chijioke, Oluwafunmilayo O Adeyemi
ETHNOPHARMACOLOGICAL RELEVANCE: Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported. There is, however, no scientific report on its toxicity profile to the best of our knowledge. AIM OF THE STUDY: This study was therefore aimed at investigating the toxicity profile of the aqueous extract of Aerva lanata...
June 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28665730/cutaneous-leiomyosarcoma-with-multiple-visceral-metastases-in-a-domestic-pigeon
#12
Tomasz Stenzel, Michał Gesek, Katarzyna Paździor-Czapula, Iwona Otrocka-Domagała, Andrzej Koncicki
A clinical examination of a 4-yr-old fantail pigeon revealed a large skin tumor in the area of the left wing. The tumor had solid consistency and a single cavity filled with fluid. During necropsy, multiple tumors of varied size and diameter were found in the liver, spleen, pancreas, and kidneys. A histopathological examination of the skin tumor revealed extensive multifocal neoplasia with a tendency to infiltrate, composed of polygonal, round, oval, and elongated cells forming a solid system with cellular bands and obliteration of intercellular boundaries...
June 2017: Avian Diseases
https://www.readbyqxmd.com/read/28665728/acute-lameness-in-a-roller-pigeon-columba-livia-with-multicentric-lymphosarcoma
#13
Susan M Williams, Robert J Williams, Robert M Gogal
A 3-yr-old adult female roller pigeon ( Columba livia ) used as part of a breeding pair for an ongoing research study presented with acute left limb lameness. Palpation of the left leg and region revealed a large lump near the coxofemoral joint. The bird was able to ambulate in the cage, but would not brood her hatchling. The bird was humanely euthanized and necropsy was performed. Grossly, multiple large white to pale tan nodules were noted in the pancreas, lung, rib cage, intestines, and unilaterally in the left kidney...
June 2017: Avian Diseases
https://www.readbyqxmd.com/read/28665480/simultaneous-pancreas-kidney-transplant-recipients-are-predisposed-to-tissue-invasive-cytomegalovirus-disease-and-concomitant-infectious-complications
#14
Thomas Schachtner, Marina Zaks, Natalie M Otto, Andreas Kahl, Petra Reinke
BACKGROUND: Infections have increased in simultaneous pancreas/kidney transplant recipients (SPKTRs) with cytomegalovirus (CMV) infection being the most important viral infection with adverse impact on patient and allograft outcomes. METHODS: We studied all primary SPKTRs and deceased-donor kidney transplant recipients (KTRs) between 2008 and 2015 for the development of CMV infection. 21/62 SPKTRs (33.9%) and 90/335 KTRs (26.9%) were diagnosed with CMV infection...
June 30, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28663128/infectious-spleen-and-kidney-necrosis-disease-isknd-outbreaks-in-farmed-barramundi-lates-calcarifer-in-vietnam
#15
H T Dong, S Jitrakorn, P Kayansamruaj, N Pirarat, C Rodkhum, T Rattanarojpong, S Senapin, V Saksmerprome
Emergence of a disease with clinical signs resembling megalocytivirus infection seriously affected large-scale barramundi farms in Vietnam in 2012-2014 with estimated losses reaching $435,810 per year. An oil-based, inactivated vaccine against red sea bream iridovirus (RSIV) was applied in one farm for disease prevention without analysis of the causative agent, and the farmer reported inadequate protection. Here we describe histological and molecular analysis of the diseased fish. PCR targeting the major capsid protein (MCP) of megalocytiviruses yielded an amplicon with high sequence identity to infectious spleen and kidney necrosis virus (ISKNV) genotype II previously reported from other marine fish but not barramundi...
June 27, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28662504/anti-diabetic-effects-of-the-ethyl-acetate-fraction-of-trichilia-catigua-in-streptozo-tocin-induced-type-1-diabetic-rats
#16
Rodrigo Mello Gomes, Luis Fernando de Paulo, Cynthia Priscilla do Nascimento Bonato Panizzon, Camila Quaglio Neves, Bruna Colombo Cordeiro, Jacqueline Nelisis Zanoni, Flávio Andrade Francisco, Silvano Piovan, Paulo Cezar de Freitas Mathias, Renata Longhini, João Carlos Palazzo de Mello, Júlio Cezar de Oliveira, Gustavo Rodrigues Pedrino, Angela Adamski da Silva Reis, Alessandra Lourenço Cecchini, Maria Raquel Marçal Natali
BACKGROUND/AIMS: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. METHODS: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group)...
June 29, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28661312/mixed-donor-chimerism-following-simultaneous-pancreas-kidney-transplant
#17
Armin Rashidi, Daniel C Brennan, Ina E Amarillo, Jason R Wellen, Amanda Cashen
OBJECTIVES: Graft-versus-host disease after solid-organ transplant is exceedingly rare. Although the precise pathogenetic mechanisms are unknown, a progressive increase in donor chimerism is a requirement for its development. The incidence of mixed donor chimerism and its timeline after simultaneous pancreas-kidney transplant is unknown. MATERIALS AND METHODS: After encountering 2 cases of graft-versus-host disease after simultaneous pancreas-kidney transplant at our institution over a period of < 2 years, a collaborative pilot study was conducted by the bone marrow transplant, nephrology, and abdominal transplant surgery teams...
June 28, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28660214/liver-specific-overexpression-of-gamma-glutamyltransferase-ameliorates-insulin-sensitivity-of-male-c57bl-6-mice
#18
Yang Long, Dan Jia, Libin Wei, Yumei Yang, Haoming Tian, Tao Chen
In the current study, we developed a liver-specific GGT-overexpressing mice model by rapid injection pLIVE-GGT vector through tail vein and investigated the effects of GGT elevation on glucose metabolism and insulin sensitivity. The serum GGT activity was significantly increased after 7 days of pLIVE-GGT1 vector delivery and lasted for about 3 weeks. GGT overexpression reduced the levels of GSSG and GSH in the liver and serum and had no effects on total antioxidative capacity in the liver, kidney, and skeletal muscle except for the pancreas...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28659807/elucidation-of-arctigenin-pharmacokinetics-and-tissue-distribution-after-intravenous-oral-hypodermic-and-sublingual-administration-in-rats-and-beagle-dogs-integration-of-in-vitro-and-in-vivo-findings
#19
Jie Li, Xin Li, Yu-Shan Ren, Yuan-Yuan Lv, Jun-Sheng Zhang, Xiao-Li Xu, Xian-Zhen Wang, Jing-Chun Yao, Gui-Min Zhang, Zhong Liu
Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated. The purpose of this work was to identify the pharmacokinetic properties of AG via various experiments in vivo and in vitro. In this research, rats and beagle dogs were used to investigate the PK (pharmacokinetics, PK) profiles of AG with different drug-delivery manners, including intravenous (i...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28659680/isolated-double-gastric-perforation-in-blunt-abdominal-trauma-a-case-report
#20
Husain M Gheewala, Snehajit Wagh, Surajsinh A Chauhan, Sonam M Devlekar, Shruti Bhave, Dharmesh J Balsarkar
Blunt abdominal trauma mostly results from motor vehicle accidents, recreational accidents, falls or assaults with commonly injured internal organs being the spleen, liver, retroperitoneum, small bowel, kidneys, bladder, colorectal, diaphragm and pancreas. Gastric rupture is quite uncommon. Isolated gastric perforations following blunt trauma to the abdomen are mostly seen in paediatric patients. It is uncommon in adult patients and even rarer is the occurrence of double gastric perforations. We report here with a case of isolated double gastric perforation in a 24-year-old male patient following vehicular accident...
June 2017: Indian Journal of Surgery
keyword
keyword
116976
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"