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https://www.readbyqxmd.com/read/29221445/study-protocol-of-hgcsg1404-snow-study-a-phase-i-ii-trial-of-combined-chemotherapy-of-s-1-nab-paclitaxel-and-oxaliplatin-administered-biweekly-to-patients-with-advanced-gastric-cancer
#1
Yasuyuki Kawamoto, Yoshito Komatsu, Satoshi Yuki, Kentaro Sawada, Tetsuhito Muranaka, Kazuaki Harada, Hiroshi Nakatsumi, Hiraku Fukushima, Atsushi Ishiguro, Masayoshi Dazai, Kazuteru Hatanaka, Michio Nakamura, Ichiro Iwanaga, Minoru Uebayashi, Susumu Sogabe, Yoshimitsu Kobayashi, Takuto Miyagishima, Kota Ono, Naoya Sakamoto, Yuh Sakata
BACKGROUND: In Japan, S-1 plus cisplatin (SP) regimen has become a standard therapy for patients with advanced gastric cancer. Moreover, the S-1 plus oxaliplatin regimen is now a standard treatment. Nab-paclitaxel was developed for chemotherapy of gastric cancer in Japanese clinical practice. Nab-paclitaxel, created with albumin-bound paclitaxel particles, has high transferability to tumour tissues and does not cause hypersensitivity reactions because of a different chemical composition compared with docetaxel and paclitaxel...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29216373/protective-effect-of-maternal-influenza-vaccination-on-influenza-in-their-infants-a-prospective-cohort-study
#2
Satoko Ohfuji, Masaaki Deguchi, Daisuke Tachibana, Masayasu Koyama, Tetsu Takagi, Takayuki Yoshioka, Akinori Urae, Kazuya Ito, Tetsuo Kase, Akiko Maeda, Kyoko Kondo, Wakaba Fukushima, Yoshio Hirota
Background: Infants under 6 months of age are too young to receive influenza vaccine, despite being at high risk for severe influenza-related complications. Methods: To examine the effectiveness of maternal influenza vaccination in preventing infants' influenza, we conducted a prospective cohort study among 3,441 infants born at the participating hospitals before the 2013/14 influenza season. At the time of recruitment, their mothers completed the questionnaire about influenza vaccination status for the 2013/14 season...
December 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29213010/continuous-improvement-of-fitness-for-duty-management-programs-for-workers-engaging-in-stabilizing-and-decommissioning-work-at-the-fukushima-daiichi-nuclear-power-plant
#3
Koji Mori, Seiichiro Tateishi, Tatsuhiko Kubo, Yuichi Kobayashi, Ko Hiraoka, Futoshi Kawashita, Takeshi Hayashi, Yoshifumi Kiyomoto, Masaki Kobashi, Kota Fukai, Hiroyuki Tahara, Ryuji Okazaki, Akira Ogami, Kazuyuki Igari, Katsunori Suzuki, Hiroshi Kikuchi, Kazuhiro Sakai
BACKGROUND: Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the accident. Given the hazards and stress involved in these tasks and the relatively long time required to transport sick or injured workers to medical institutions, it became necessary to quickly implement a more stringent management program for fitness for duty than in ordinary work environments...
December 6, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29202869/prognostic-significance-of-hepatocyte-growth-factor-activator-inhibitor-type-1-hai-1-immunoreactivity-in-pancreatic-ductal-adenocarcinoma
#4
Chihiro Sakugawa, Yukihiro Haruyama, Hiroyuki Tanaka, Tsuyoshi Fukushima, Makiko Kawaguchi, Hiroaki Kataoka
OBJECTIVE: Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine protease inhibitor that is expressed on the surface of epithelial cells. Evidence has suggested that decreased cell surface HAI-1 in carcinoma cells results in enhanced invasiveness. However, little is known regarding the expression of HAI-1 in pancreatic ductal adenocarcinoma (PDAC). This study aimed to analyze HAI-1 expression in PDAC and its impact on patient prognosis. RESULTS: HAI-1 immunohistochemistry was performed on samples from 67 PDAC cases...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29199242/a-single-step-breeding-generated-a-diagnostic-anti-cortisol-antibody-fragment-with-over-30-fold-enhanced-affinity
#5
Hiroyuki Oyama, Izumi Morita, Yuki Kiguchi, Tomomi Morishita, Sakiko Fukushima, Yuki Nishimori, Toshifumi Niwa, Norihiro Kobayashi
Cortisol levels in bodily fluids represent a useful index for pituitary-adrenal function, and thus practical anti-cortisol antibodies are required. We have studied "antibody-breeding" approaches, which involve in vitro evolution of antibodies to improve their antigen-binding performances. Here, we produced an antibody fragment to measure serum cortisol levels with over 30-fold enhanced affinity after single mutagenesis and selection steps. A mouse anti-cortisol antibody, Ab-CS#3, with insufficient affinity for practical use, was chosen as the prototype antibody...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29198694/reversible-cerebral-vasoconstriction-syndrome-after-heart-transplantation-a-case-report
#6
Y Kumai, O Seguchi, T Sato, K Wada, M Shiozawa, C Yokota, K Kuroda, S Nakajima, T Sato, M Yanase, Y Matsumoto, S Fukushima, T Fujita, J Kobayashi, N Fukushima
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a transient cerebrovascular disorder putatively caused by some immunosuppressive agents. CASE REPORT: We recently encountered a 47-year-old female patient diagnosed with dilated cardiomyopathy who developed RCVS after heart transplantation. A triple-drug regimen consisting of tacrolimus, mycophenolate mofetil, and a corticosteroid was started after surgery. On postoperative day (POD) 11, the patient developed a severe headache, although computed tomography of the head demonstrated no signs of hemorrhage or infarction...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29198044/lifestyle-factors-and-social-ties-associated-with-the-frequency-of-laughter-after-the-great-east-japan-earthquake-fukushima-health-management-survey
#7
Mayumi Hirosaki, Tetsuya Ohira, Seiji Yasumura, Masaharu Maeda, Hirooki Yabe, Mayumi Harigane, Hideto Takahashi, Michio Murakami, Yuriko Suzuki, Hironori Nakano, Wen Zhang, Mayu Uemura, Masafumi Abe, Kenji Kamiya
PURPOSE: Although mental health problems such as depression after disasters have been reported, positive psychological factors after disasters have not been examined. Recently, the importance of positive affect to our health has been recognised. We therefore investigated the frequency of laughter and its related factors among residents of evacuation zones after the Great East Japan Earthquake of 2011. METHODS: In a cross-sectional study on 52,320 participants aged 20 years and older who were included in the Fukushima Health Management Survey in Japan's fiscal year 2012, associations of the frequency of laughter with changes in lifestyle after the disaster, such as a changed work situation, the number of family members, and the number of address changes, and other sociodemographic, psychological, and lifestyle factors were examined using logistic regression analysis...
December 2, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29197810/an-assessment-on-the-environmental-contamination-caused-by-the-fukushima-accident
#8
Jin Ho Song
The radiological releases from the damaged fuel to the atmosphere and into the cooling water in the Fukushima Daiich Nuclear Power Plant (FDNPP) accident are investigated. Atmospheric releases to the land and ocean mostly occurred during the first week after the accident whereas continuous release from the damaged fuel into the cooling water resulted in an accumulation of contaminated water in the plant during last six years. An evaluation of measurement data and analytical model for the release of radionuclides indicated that atmospheric releases were mainly governed by the volatility of the radionuclides...
November 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29197749/radiocesium-uptake-through-leaf-surfaces-of-tea-plants-camellia-sinensis-l
#9
Takashi Ikka, Yoshifumi Nishina, Mizuho Kamoshita, Yasuhisa Oya, Kenji Okuno, Akio Morita
To clarify the source of radiocesium detected in newly emerged tea leaves contaminated just before the time of bud opening by fallout of radionuclides from Fukushima Dai-ichi Nuclear Power Plant, 137CsCl solution (0.185 M Bq mL-1) was applied to the front or the backside surfaces of mature leaves of tea plant (Camellia sinensis L. cv. Yabukita) at the time of bud opening. A 21 days after foliar application, the buds had grown and developed to the three- or four-leaf stage. In the front treatment, almost all (95%) of the applied 137Cs was present in the mature leaves (hot mother leaves)...
November 30, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29197520/effects-of-pirfenidone-in-acute-and-sub-chronic-liver-fibrosis-and-an-initiation-promotion-cancer-model-in-the-mouse
#10
Oleksii Seniutkin, Shinji Furuya, Yu-Syuan Luo, Joseph A Cichocki, Hisataka Fukushima, Yuki Kato, Hiromi Sugimoto, Tomoko Matsumoto, Takeki Uehara, Ivan Rusyn
Liver fibrosis results from chronic tissue damage and excessive regeneration with accumulation of extracellular matrix proteins; it is a precursor of liver cirrhosis and hepatocellular carcinoma. Liver fibrosis treatments are primarily directed at inflammation, with few options to combat fibrogenesis. Pirfenidone is a drug approved for idiopathic pulmonary fibrosis and this study was focused on anti-fibrotic and anti-cancer potential of pirfenidone in the liver of male B6C3F1/J mice. In a dose-finding study, mice were treated with CCl4 (0...
November 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29197480/imagerie-par-r%C3%A3-sonance-magn%C3%A3-tique-de-diffusion-d-un-nodule-de-s%C3%A5-ur-marie-joseph
#11
Kenichiro Sato, Yasuyoshi Fukushima
No abstract text is available yet for this article.
December 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29197479/magnetic-resonance-diffusion-weighted-image-of-sister-mary-joseph-s-nodule
#12
Kenichiro Sato, Yasuyoshi Fukushima
No abstract text is available yet for this article.
December 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29194762/cholinesterase-levels-predict-exercise-capacity-in-cardiac-recipients-early-after-transplantation
#13
Kazufumi Kitagaki, Michio Nakanishi, Rei Ono, Kazuya Yamamoto, Yuji Suzuki, Noriyuki Fukui, Hidetoshi Yanagi, Harumi Konishi, Masanobu Yanase, Norihide Fukushima
PURPOSE: Although cardiac rehabilitation is recommended for patients early after heart transplantation (HTx), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition during waiting for HTx. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after HTx. PATIENTS AND METHODS: Forty three HTx recipients were studied...
December 1, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29191371/rat-bite-fever-due-to-streptobacillus-notomytis-isolated-from-a-human-specimen
#14
Kazuaki Fukushima, Naoki Yanagisawa, Koichi Imaoka, Masanobu Kimura, Akifumi Imamura
Rat-bite fever (RBF) is a disease that usually presents with fever, arthralgia and skin rash. Streptobacillus moniliformis was considered the main cause of RBF among the genus Streptobacillus. Although with similar clinical presentation, RBF due to Streptobacillus notomytis is unusual in humans. To the best of our knowledge, we present a case involving the first isolate of S. notomytis in humans. A 63-year-old woman was admitted to our hospital with fever, rash and polyarthritis. She recalled being bitten by a rat on her finger 5 days before presentation...
November 27, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29190637/standard-dose-osimertinib-for-refractory-leptomeningeal-metastases-in-t790m-positive-egfr-mutant-non-small-cell-lung-cancer
#15
Shigeki Nanjo, Akito Hata, Chiyuki Okuda, Reiko Kaji, Hideaki Okada, Daisuke Tamura, Kei Irie, Hiroshi Okada, Shoji Fukushima, Nobuyuki Katakami
BACKGROUND: Osimertinib demonstrated promising efficacy for refractory leptomeningeal metastases (LM) in preclinical data and a clinical study at 160 mg, but there is limited data for the standard 80 mg dose. METHODS: T790M-positive patients with suspected LM after classical epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) failure were enroled. RESULTS: We investigated 13 patients (5 definitive and 8 possible LM cases)...
November 30, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29190508/evaluation-of-sediment-and-137cs-redistribution-in-the-oginosawa-river-catchment-near-the-fukushima-dai-ichi-nuclear-power-plant-using-integrated-watershed-modeling
#16
Kazuyuki Sakuma, Alex Malins, Hironori Funaki, Hiroshi Kurikami, Tadafumi Niizato, Takahiro Nakanishi, Koji Mori, Kazuhiro Tada, Takamaru Kobayashi, Akihiro Kitamura, Masaaki Hosomi
The Oginosawa River catchment lies 15 km south-west of the Fukushima Dai-ichi nuclear plant and covers 7.7 km2. Parts of the catchment were decontaminated between fall 2012 and March 2014 in preparation for the return of the evacuated population. The General-purpose Terrestrial Fluid-flow Simulator (GETFLOWS) code was used to study sediment and 137Cs redistribution within the catchment, including the effect of decontamination on redistribution. Fine resolution grid cells were used to model local features of the catchment, such as paddy fields adjacent to the Oginosawa River...
November 27, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29188790/irpa-consultation-is-the-system-of-protection-fit-for-purpose-and-can-it-be-readily-communicated-views-of-the-radiation-protection-professionals
#17
Roger Coates, Renate Czarwinski
The system of protection, which provides the basic underpinning philosophy and principles for radiation protection, is constantly evolving in the light of developing scientific understanding and practical experience. Over recent times there has been significant learning from experiences relating to the Fukushima accident, and there is also increasing recognition of the importance of enhancing public understanding of radiation and risk. The practical application of radiation protection is undertaken by thousands of practitioners around the world, and it is IRPA's task to ensure that this experience is fed back for the benefit of all...
November 30, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29188387/efficacy-and-safety-of-twice-daily-rabeprazole-maintenance-therapy-for-patients-with-reflux-esophagitis-refractory-to-standard-once-daily-proton-pump-inhibitor-the-japan-based-extend-study
#18
Yoshikazu Kinoshita, Mototsugu Kato, Mitsuhiro Fujishiro, Hironori Masuyama, Ryo Nakata, Hisanori Abe, Shinji Kumagai, Yasushi Fukushima, Yoshiumi Okubo, Seiichiro Hojo, Motoyasu Kusano
BACKGROUND: Rabeprazole at 10 or 20 mg twice daily (b.i.d.) has been reported to be highly effective in the treatment of proton pump inhibitor (PPI)-resistant reflux esophagitis (RE) that is refractory to the standard once-daily PPI regimen. We evaluated the efficacy and safety of rabeprazole maintenance therapy at 10 mg once daily (q.d.) or b.i.d. for longer than 8 weeks. METHODS: Patients with RE refractory to standard PPI regimens for at least 8 weeks were enrolled...
November 29, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29185733/gram-scale-syntheses-and-conductivities-of-10-cycloparaphenylene-and-its-tetraalkoxy-derivatives
#19
Eiichi Kayahara, Liansheng Sun, Hiroaki Onishi, Katsuaki Suzuki, Tatsuya Fukushima, Ayaka Sawada, Hironori Kaji, Shigeru Yamago
[10]cycloparaphenylene ([10]CPP) and its tetraalkoxy derivatives were synthesized on the gram scale in 7 steps starting from 1,4-benzoquinone or 2,5-dialkoxy-1,4-benzoquinone. The key steps involve the highly cis-selective bis-addition of 4-bromo-4'-lithiobipheny to the quinones to produce a five-ring unit contain-ing cyclohexa-1,4-diene-3,6-diol moiety, the platinum-mediated dimerization of the five-ring unit, and the H2SnCl4-mediated reductive aromatization of cyclohexadienediol. The tetraalkoxy substituents increased the solubility of [10]CPP in common or-ganic solvents...
November 29, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29183681/effects-of-repeated-nerve-injuries-at-different-time-intervals-on-functional-recovery-and-nerve-innervation
#20
Mika Karasawa, Kumiko Yokouchi, Kyutaro Kawagishi, Tetsuji Moriizumi, Nanae Fukushima
Effects of repeated nerve injuries on functional recovery and nerve innervation were examined in rodents. Crush injuries of the sciatic nerve were inflicted on adult rats and repeated twice or thrice at different time intervals of 1, 2, 3, and 4 weeks. Motor function was assessed by the static sciatic index at 1, 7, 14, 21, 28, 35, 42, 49, and 56 days after the final crush. The rates of nerve innervation of the tibialis anterior muscle, a main muscle innervated by the common peroneal nerve, were evaluated by the quantification of βIII-tubulin-positive nerve terminals and α-bungarotoxin-positive acetylcholine receptors 21 and 56 days after the final crush of triple nerve injuries at 1-, 2-, 3-, and 4-week intervals...
November 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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