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https://www.readbyqxmd.com/read/28528465/contrast-induced-nephropathy-cin-of-patients-with-renal-dysfunction-in-ct-examination
#1
Yasuhiro Fukushima, Hitomi Miyazawa, Junpei Nakamura, Ayako Taketomi-Takahashi, Takayuki Suto, Yoshito Tsushima
PURPOSE: To investigate the incidence and risk factors of contrast induced nephropathy (CIN) after contrast enhanced (CE) computed tomography (CT) in patients with renal dysfunction. MATERIALS AND METHODS: Two hundred sixteen inpatients with estimated glomerular filtration rates (eGFR) <60 ml/min/1.73 m(2) underwent CE CT using iodine doses of 420 or 480 mg I/kg. Data of all enrolled patients was collected for baseline serum creatinine level (SCr), post-CE CT SCr within 3 days after CE CT, and conditions considered risk factors for CIN [renal dysfunction, contrast media dose, advanced age, diabetes mellitus, no intravenous hydration, cardiac dysfunction (left ventricular ejection fraction <60%) and intensive-care unit (ICU) admission]...
May 20, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28522882/monoclonal-suncus-antibodies-generation-of-fusion-partners-to-produce-suncus-suncus-hybridomas
#2
Yoshikazu Sado, Satoko Inoue, Yasuko Tomono, Makoto Matsuyama, Masaki Fukushima, Toshitaka Oohashi, Takamichi Jogahara, Sen-Ichi Oda
We used suncus (Suncus murinus; house musk shrew) to generate partner cells for cell fusion to produce suncus monoclonal antibodies. Suncus are insectivores that are genetically distant to rodents, and recognize antigens and epitopes that are not immunogenic in mice and rats, which are the animals most commonly used in basic life science research and from which monoclonal antibodies are usually produced. To date, monoclonal antibodies from suncus have not been generated due to the lack of a plasmacytoma fusion partner...
April 27, 2017: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/28516892/current-situations-and-discussions-in-japan-in-relation-to-the-new-occupational-equivalent-dose-limit-for-the-lens-of-the-eye
#3
Sumi Yokoyama, Nobuyuki Hamada, Toshiyuki Hayashida, Norio Tsujimura, Hideo Tatsuzaki, Tadahiro Kurosawa, Kuniaki Nabatame, Hiroyuki Ohguchi, Kazuko Ohno, Chiyo Yamauchi-Kawaura, Takeshi Iimoto, Takeshi Ichiji, Yutaka Hotta, Satoshi Iwai, Keiichi Akahane
Since the International Commission on Radiological Protection recommended reducing the occupational equivalent dose limit for the lens of the eye in 2011, extensive discussions have been made in various countries. This paper reviews current situations in radiation protection of the ocular lens and discussions on the potential impact of the new lens dose limit in Japan. Topics include historical changes in the lens dose limit, current situations in occupational lens exposures (e.g., in medical workers, nuclear workers, and Fukushima nuclear power plant workers) and measurements, current status of biological studies and epidemiological studies on radiation cataracts...
May 18, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28516769/identification-of-rotundone-as-a-potent-odor-active-compound-of-several-kinds-of-fruits
#4
Akira Nakanishi, Yusuke Fukushima, Norio Miyazawa, Keisuke Yoshikawa, Tomoko Maeda, Yoshiko Kurobayashi
An investigation of the aromas of grapefruit, orange, apple, and mango revealed the presence of an odor-active compound that gave off a strong woody odor when assessed by gas chromatography-olfactometry. We isolated the compound from a high-boiling fraction of an orange essential oil, and subsequent nuclear magnetic resonance analyses of the isolated compound identified it as rotundone. Mass spectra and retention indices obtained from aroma concentrates of grapefruit, apple, and mango were identical to those of rotundone, which was therefore determined to be the common woody compound in these fruits...
May 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28510538/measuring-and-assessing-individual-external-doses-during-the-rehabilitation-phase-in-iitate-village-after-the-fukushima-daiichi-nuclear-power-plant-accident
#5
Wataru Naito, Motoki Uesaka, Tadahiro Kurosawa, Yujiro Kuroda
After the Fukushima Daiichi Nuclear Power Plant accident in 2011, Iitate village was placed under an evacuation order because the level of radioactive materials drifting from the nuclear plant to the village were above a government-set level for allowing residents to live in the area. The evacuation advisory for most of the village was lifted on March 31, 2017. For displaced residents deciding whether or not to return to their homes, it is important to correctly understand and estimate the realistic individual external doses they will receive after returning to the village...
May 16, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28506309/social-isolation-and-cancer-management-advanced-rectal-cancer-with-patient-delay-following-the-2011-triple-disaster-in-fukushima-japan-a-case-report
#6
Akihiko Ozaki, Claire Leppold, Toyoaki Sawano, Masaharu Tsubokura, Manabu Tsukada, Tetsuya Tanimoto, Masahiro Kami, Hiromichi Ohira
BACKGROUND: Little is known about the effects of social isolation in the elderly on their process of gaining health information and seeking health care. CASE PRESENTATION: In March 2011, Fukushima, Japan experienced an earthquake, tsunami, and nuclear disaster, also known as Japan's triple disaster. In June 2016, an 80-year-old Japanese man, who lived alone after divorce at the age of 42, presented to our hospital with bloody stools and dizziness. Although his bloody stools initially occurred in May 2015, a year earlier, he did not pursue the possibility of malignancy...
May 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28506276/redo-coronary-bypass-grafting-for-congenital-left-main-coronary-atresia-a-case-report
#7
Shin Yajima, Koichi Toda, Hiroyuki Nishi, Daisuke Yoshioka, Teruya Nakamura, Shigeru Miyagawa, Yasushi Yoshikawa, Satsuki Fukushima, Yoshiki Sawa
BACKGROUND: Congenital left main coronary atresia is an extremely rare coronary anomaly. Long-term surgical outcomes and the optimal management strategies for recurrence of ischemia remain uncertain. Herein, we present a case involving successful redo coronary artery bypass grafting for unstable angina 27 years after the initial coronary artery bypass grafting for congenital left main coronary atresia. CASE PRESENTATION: A 33-year-old woman was referred to our department with unstable angina...
May 15, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28506111/comment-on-comprehensive-survey-results-of-childhood-thyroid-ultrasound-examinations-in-fukushima-in-the-first-four-years-after-the-fukushima-daiichi-nuclear-power-plant-accident
#8
https://www.readbyqxmd.com/read/28506004/relationships-between-geometrical-parameters-and-mechanical-properties-for-a-helical-braided-flow-diverter-stent
#9
Takashi Suzuki, Hiroyuki Takao, Soichiro Fujimura, Chihebeddine Dahmani, Toshihiro Ishibashi, Hiroya Mamori, Naoya Fukushima, Yuichi Murayama, Makoto Yamamoto
BACKGROUND: Although flow diversion is a promising procedure for aneurysm treatment, the safety and efficacy of this strategy have not been sufficiently characterized. Both mechanical properties and flow reduction effects are important factors in the design of an optimal stent. OBJECTIVE: We aimed to clarify the contributions of strut size and pitch to the mechanical properties (radial stiffness and longitudinal flexibility) and geometric characteristics (porosity and pore density) related to flow reduction effects...
May 1, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28505504/standardization-of-the-apparent-diffusion-coefficient-value-of-bladder-cancer-across-different-centers-applicability-in-predicting-aggressive-pathologic-phenotypes
#10
Toshinori Nishizawa, Soichiro Yoshida, Fumitaka Koga, Hiroshi Tanaka, Mihiro Kaga, Kotaro Watanabe, Hiroshi Fukushima, Yasukazu Nakanishi, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii, Kazunori Kihara
PURPOSE: We investigated whether the standardized apparent diffusion coefficient (ADC) value reflects bladder cancer characteristics across different centers. METHODS: Ninety-eight bladder cancer patients underwent MRI at two institutions. Standardized tumor ADC (sT-ADC) was calculated by dividing absolute tumor ADC (aT-ADC) by that of gluteus maximus. We compared ADCs between MRI protocols according to grade and T-stage. RESULTS: The differences in aT-ADC between MRI protocols were negated by sT-ADC...
May 5, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28505478/dose-assessment-in-environmental-radiological-protection-state-of-the-art-and-perspectives
#11
REVIEW
Karolina Stark, José M Goméz-Ros, Jordi Vives I Batlle, Elisabeth Lindbo Hansen, Karine Beaugelin-Seiller, Lawrence A Kapustka, Michael D Wood, Clare Bradshaw, Almudena Real, Corynne McGuire, Thomas G Hinton
Exposure to radiation is a potential hazard to humans and the environment. The Fukushima accident reminded the world of the importance of a reliable risk management system that incorporates the dose received from radiation exposures. The dose to humans from exposure to radiation can be quantified using a well-defined system; its environmental equivalent, however, is still in a developmental state. Additionally, the results of several papers published over the last decade have been criticized because of poor dosimetry...
May 12, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28503890/co-morbidity-and-quality-of-life-in-childhood-cancer-survivors-treated-with-proton-beam-therapy
#12
Hiroko Fukushima, Takashi Fukushima, Ryoko Suzuki, Atsushi Iwabuchi, Kyoko Hidaka, Kouji Masumoto, Ai Muroi, Tetsuya Yamamoto, Masashi Mizumoto, Hideyuki Sakurai, Ryo Sumazaki
INTRODUCTION: The ratio of childhood cancer survival achieves over 80% recently. Various adverse events among childhood cancer survivors (CCSs) has been reported. Proton beams are able to avoid unnecessary irradiation to normal/vital organs. We conducted a quality of life (QOL) study for CCSs who were treated with proton beam therapy (PBT). MATERIALS AND METHODS: We included those treated with PBT to the brain, head, or neck ≤15 years old at the University of Tsukuba Hospital from 1983 to 2011...
May 14, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28502954/acute-prevertebral-calcific-tendinitis
#13
Taro Shibuki, Hirofumi Goto, Kosuke Fukushima, Toshihiko Mizuta
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28498040/pivotal-role-of-non-cardiomyocytes-in-electromechanical-and-therapeutic-potential-of-induced-pluripotent-stem-cell-derived-engineered-cardiac-tissue
#14
Hiroko Iseoka, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Shigeo Masuda, Shin Yajima, Emiko Ito, Nagako Sougawa, Maki Takeda, Akima Harada, Jong-Kook Lee, Yoshiki Sawa
Although engineered cardiac tissues (ECTs) derived from induced pluripotent stem cells (iPSCs) are promising for myocardial regenerative therapy, the appropriate ratio of cardiomyocytes to non-cardiomyocytes is not fully understood. Here, we determined whether ECT-cell content is a key determinant of its structure/function, thereby affecting ECT therapeutic potential for advanced heart failure. Scaffold-free ECTs containing different ratios (25%, 50%, 70%, or 90%) of iPSC-derived cardiomyocytes were generated by magnetic-activated cell sorting using cardiac-specific markers...
May 12, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28494704/endoscopic-cytology-for-the-diagnosis-of-chronic-enteritis-and-intestinal-lymphoma-in-dogs
#15
S Maeda, M Tsuboi, K Sakai, K Ohno, K Fukushima, H Kanemoto, S Hiyoshi-Kanemoto, Y Goto-Koshino, J K Chambers, T Yonezawa, K Uchida, N Matsuki
Although cytology is a rapid diagnostic procedure in dogs, the cytologic criteria of endoscopic biopsies for chronic enteritis and intestinal lymphoma are not well defined. An immediate diagnosis using cytology would benefit patients by enabling prompt initiation of therapy. The objective of this study was to investigate the correlation between the results of endoscopic cytology and histopathology. In this study, 167 dogs with clinical signs of chronic gastrointestinal disease were included. On the basis of histopathology, the following diagnoses were determined: lymphocytic-plasmacytic enteritis in 93 dogs; eosinophilic enteritis in 5 dogs; small cell intestinal lymphoma in 45 dogs; and large cell intestinal lymphoma in 24 dogs...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28483620/clinical-outcomes-of-spinal-cord-ischemia-after-fenestrated-and-branched-endovascular-stent-grafting-during-total-endovascular-aortic-repair-for-thoracoabdominal-aortic-aneurysms
#16
Takeshi Baba, Takao Ohki, Yuji Kanaoka, Koji Maeda, Hiroki Ohta, Soichirou Fukushima, Naoki Toya, Masayuki Hara
PURPOSE: In this single-center study, we assessed the clinical outcomes of fenestrated-endovascular aortic repair (f-EVAR) and branched EVAR on morbidity and mortality during total endovascular aortic repair for thoracoabdominal aortic aneurysms (TAAAs). METHODS: Between July 2006 and June 2015, elective f-EVAR and multibranched EVAR (t-Branch) for TAAAs were performed in 99 patients at our institution [Crawford classification types I (7), II (13), III (6), IV (55), and V (18)]...
May 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28483042/reproducible-diagnostic-metabolites-in-plasma-from-typhoid-fever-patients-in-asia-and-africa
#17
Elin Näsström, Christopher M Parry, Nga Tran Vu Thieu, Rapeephan R Maude, Hanna K de Jong, Masako Fukushima, Olena Rzhepishevska, Florian Marks, Ursula Panzner, Justin Im, Hyonjin Jeon, Seeun Park, Zabeen Chaudhury, Aniruddha Ghose, Rasheda Samad, Tan Trinh Van, Anders Johansson, Arjen M Dondorp, Guy E Thwaites, Abul Faiz, Henrik Antti, Stephen Baker
Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Näsström et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients...
May 9, 2017: ELife
https://www.readbyqxmd.com/read/28469071/tetrahydrobiopterin-activates-brown-adipose-tissue-and-regulates-systemic-energy-metabolism
#18
Yasuo Oguri, Yoshihito Fujita, Abulizi Abudukadier, Akiko Ohashi, Tsuyoshi Goto, Futoshi Furuya, Akio Obara, Toru Fukushima, Naomi Matsuo, Minji Kim, Masaya Hosokawa, Teruo Kawada, Hiroyuki Hasegawa, Nobuya Inagaki
Brown adipose tissue (BAT) is a central organ that acts to increase energy expenditure; its regulatory factors could be clinically useful in the treatment of obesity. Tetrahydrobiopterin (BH4) is an essential cofactor of tyrosine hydroxylase and nitric oxide synthase (NOS). Although BH4 regulates the known regulatory factors of BAT, such as noradrenaline (NA) and NO, participation of BH4 in BAT function remains unclear. In the present study, we investigate the role of BH4 in the regulation of BAT. Hph-1 mice, a mouse model of BH4 deficiency, exhibit obesity, adiposity, glucose intolerance, insulin resistance, and impaired BAT function...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28464833/light-and-sporadic-physical-activity-overlooked-by-current-guidelines-makes-older-women-more-active-than-older-men
#19
Shiho Amagasa, Noritoshi Fukushima, Hiroyuki Kikuchi, Tomoko Takamiya, Koichiro Oka, Shigeru Inoue
BACKGROUND: Men are generally believed to be more physically active than women when evaluated using current physical activity (PA) guidelines, which count only moderate-to-vigorous physical activity (MVPA) in bouts lasting at least 10 min. However, it remains unclear men are truly more physically active provided that all-intensity PA are evaluated. This population based cross-sectional study aimed to examine gender differences in patterns of objectively-assessed PA in older adults. METHODS: One thousand two hundred ten community-dwelling Japanese older adults who were originally randomly selected from residential registry of three municipalities were asked to respond a questionnaire and wear an accelerometer (HJA-350IT, Omron Healthcare)...
May 2, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28463812/preparation-of-dual-stimuli-responsive-liposomes-using-methacrylate-based-copolymers-with-ph-and-temperature-sensitivities-for-precisely-controlled-release
#20
Takumi Sugimoto, Naoko Yamazaki, Takaaki Hayashi, Eiji Yuba, Atsushi Harada, Aki Kotaka, Chiharu Shinde, Takayuki Kumei, Yasushi Sumida, Mitsuhiro Fukushima, Yuki Munekata, Keiichi Maruyama, Kenji Kono
Dual-signal-sensitive copolymers were synthesized by copolymerization of methoxy diethylene glycol methacrylate, methacrylic acid, and lauroxy tetraethylene glycol methacrylate, which respectively provide temperature sensitivity, pH sensitivity, and anchoring to liposome surfaces. These novel copolymers, with water solubility that differs depending on temperature and pH, are soluble in water under neutral pH and low-temperature conditions, but they become water-insoluble and form aggregates under acidic pH and high-temperature conditions...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
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