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https://www.readbyqxmd.com/read/28822869/a-review-of-terrorism-and-its-reduction-of-the-gender-ratio-at-birth-after-seasonal-adjustment
#1
Victor Grech, Dorota Zammit
BACKGROUND: Males are born in excess of females, a ratio expressed as M/T (males:total births). The ratio exhibits seasonal variation. Furthermore, acute stressful events may result in a transient dip in male births due to excess foetal losses, reducing M/T. AIMS: This study was carried out in order to identify significant M/T dips after adjusting for seasonality. STUDY DESIGN: Live births by gender and month were sought for acute stressful events...
August 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28821768/real-time-monitoring-of-water-level-and-temperature-in-storage-fuel-pools-through-optical-fibre-sensors
#2
S Rizzolo, J Périsse, A Boukenter, Y Ouerdane, E Marin, J-R Macé, M Cannas, S Girard
We present an innovative architecture of a Rayleigh-based optical fibre sensor for the monitoring of water level and temperature inside storage nuclear fuel pools. This sensor, able to withstand the harsh constraints encountered under accidental conditions such as those pointed-out during the Fukushima-Daiichi event (temperature up to 100 °C and radiation dose level up to ~20 kGy), exploits the Optical Frequency Domain Reflectometry technique to remotely monitor a radiation resistant silica-based optical fibre i...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821761/enhanced-therapeutic-effects-of-human-ips-cell-derived-cardiomyocyte-by-combined-cell-sheets-with-omental-flap-technique-in-porcine-ischemic-cardiomyopathy-model
#3
Masashi Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Kenji Miki, Shunsuke Funakoshi, Yoshinori Yoshida, Shinya Yamanaka, Tatsuya Shimizu, Teruo Okano, Takashi Daimon, Koichi Toda, Yoshiki Sawa
Transplant of human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) cell-sheet is a promising approach for treating ischemic cardiomyopathy (ICM). However, poor blood supply to the transplanted cell-sheet is a concern related to the effectiveness and durability of the treatment. Herein, we hypothesized that the combined the omentum flap might enhance survival and the therapeutic effects of hiPS-CM cell-sheet transplant for ICM treatment. Treatment by Wnt signaling molecules in hiPS cells produced hiPS-CMs, which were magnetically labeled by superparamagnetic iron oxide (SPIO), followed by culture in the thermoresponsive dishes to generate hiPS-CMs cell-sheets...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821685/nivolumab-related-myasthenia-gravis-with-myositis-and-myocarditis-in-japan
#4
Shigeaki Suzuki, Nobuhisa Ishikawa, Fumie Konoeda, Nobuhiko Seki, Satoshi Fukushima, Kikuko Takahashi, Hisashi Uhara, Yoshikazu Hasegawa, Shinichiro Inomata, Yasushi Otani, Kenji Yokota, Takashi Hirose, Ryo Tanaka, Norihiro Suzuki, Makoto Matsui
OBJECTIVE: To report the clinical features of myasthenia gravis (MG) induced by treatment with immune checkpoint inhibitors using 2-year safety databases based on postmarketing surveys in Japan. METHODS: We studied 10,277 patients with cancer who had received monotherapy with either nivolumab or ipilimumab between September 2014 and August 2016. As the control group, 105 patients with idiopathic MG were used. RESULTS: There were 12 MG cases (0...
August 18, 2017: Neurology
https://www.readbyqxmd.com/read/28820355/alpha-particles-and-x-rays-interact-in-inducing-dna-damage-in-u2os-cells
#5
Alice Sollazzo, Beata Brzozowska, Lei Cheng, Lovisa Lundholm, Siamak Haghdoost, Harry Scherthan, Andrzej Wojcik
Survivors of the atomic bombings of Hiroshima and Nagasaki are monitored for health effects within the Life Span Study (LSS). The LSS results represent the most important source of data about cancer effects from ionizing radiation exposure, which forms the foundation for the radiation protection system. One uncertainty connected to deriving universal risk factors from these results is related to the problem of mixed radiation qualities. The A-bomb explosions generated a mixed beam of the sparsely ionizing gamma radiation and densely ionizing neutrons...
August 18, 2017: Radiation Research
https://www.readbyqxmd.com/read/28818475/oseltamivir-use-and-severe-abnormal-behavior-in-japanese-children-and-adolescents-with-influenza-is-a-self-controlled-case-series-study-applicable
#6
Wakaba Fukushima, Kotaro Ozasa, Akihisa Okumura, Masaaki Mori, Mitsuaki Hosoya, Takashi Nakano, Takuya Tanabe, Naoto Yamaguchi, Hiroshi Suzuki, Mitsuru Mori, Hideaki Hatayama, Hirotaka Ochiai, Kyoko Kondo, Kazuya Ito, Satoko Ohfuji, Yosikazu Nakamura, Yoshio Hirota
OBJECTIVE: Since the 1990s, self-controlled designs including self-controlled case series (SCCS) studies have been occasionally used in post-marketing evaluation of drug or vaccine safety. An SCCS study was tentatively applied to evaluate the relationship between oseltamivir use and abnormal behavior Type A (serious abnormal behavior potentially leading to an accident or harm to another person) in influenza patients. METHODS: From the original prospective cohort study with approximately 10,000 Japanese children and adolescents with influenza (aged <18years), 28 subjects (mean age: 7...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28818474/estimating-influenza-disease-burden-among-pregnant-women-application-of-self-control-method
#7
Satoko Ohfuji, Masaaki Deguchi, Daisuke Tachibana, Masayasu Koyama, Tetsu Takagi, Takayuki Yoshioka, Akinori Urae, Wakaba Fukushima, Yoshio Hirota
To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28818473/effectiveness-of-23-valent-pneumococcal-polysaccharide-vaccine-and-seasonal-influenza-vaccine-for-pneumonia-among-the-elderly-selection-of-controls-in-a-case-control-study
#8
Kyoko Kondo, Kanzo Suzuki, Masakazu Washio, Satoko Ohfuji, Wakaba Fukushima, Akiko Maeda, Yoshio Hirota
We conducted a case-control study to elucidate associations between pneumonia in elderly individuals and 23-valent pneumococcal polysaccharide vaccine (PPSV23) and seasonal influenza vaccine (influenza vaccine). Here, we examined selection of controls in our study using an analytic epidemiology approach. The study period was from October 1, 2009 through September 30, 2014. Cases comprised ≥65-year-old patients newly diagnosed with pneumonia. For every case with pneumonia, two patients with other diseases (one respiratory medicine, one non-respiratory medicine) who were sex-, age-, visit date- and visit hospital-matched were selected as controls...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28818471/basic-principles-of-test-negative-design-in-evaluating-influenza-vaccine-effectiveness
#9
Wakaba Fukushima, Yoshio Hirota
Based on the unique characteristics of influenza, the concept of "monitoring" influenza vaccine effectiveness (VE) across the seasons using the same observational study design has been developed. In recent years, there has been a growing number of influenza VE reports using the test-negative design, which can minimize both misclassification of diseases and confounding by health care-seeking behavior. Although the test-negative designs offer considerable advantages, there are some concerns that widespread use of the test-negative design without knowledge of the basic principles of epidemiology could produce invalid findings...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28817098/estimation-of-the-vertical-distribution-of-radiocesium-in-soil-on-the-basis-of-the-characteristics-of-gamma-ray-spectra-obtained-via-aerial-radiation-monitoring-using-an-unmanned-helicopter
#10
Kotaro Ochi, Miyuki Sasaki, Mutsushi Ishida, Shoichiro Hamamoto, Taku Nishimura, Yukihisa Sanada
After the Fukushima Daiichi Nuclear Power Plant accident, the vertical distribution of radiocesium in soil has been investigated to better understand the behavior of radiocesium in the environment. The typical method used for measuring the vertical distribution of radiocesium is troublesome because it requires collection and measurement of the activity of soil samples. In this study, we established a method of estimating the vertical distribution of radiocesium by focusing on the characteristics of gamma-ray spectra obtained via aerial radiation monitoring using an unmanned helicopter...
August 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28815892/preaxial-polydactyly-in-an-individual-with-wiedemann-steiner-syndrome-caused-by-a-novel-nonsense-mutation-in-kmt2a
#11
Takashi Enokizono, Tatsuyuki Ohto, Ryuta Tanaka, Mai Tanaka, Hisato Suzuki, Aiko Sakai, Kazuo Imagawa, Hiroko Fukushima, Atsushi Iwabuti, Takashi Fukushima, Ryo Sumazaki, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki
Wiedemann-Steiner syndrome (WDSTS) is an autosomal dominant disorder characterized by hypertrichosis, intellectual disability, and dysmorphic facial appearances (down-slanted vertically narrow palpebral fissures, wide nasal bridge, broad nasal tip, and thick eyebrows). In 2012, Jones and co-workers identified heterozygous mutations in KMT2A (lysine methyltransferase 2A) as the molecular cause of WDSTS. Although the phenotype of this syndrome continues to expand, the associated features are not fully understood...
August 16, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28812732/genome-of-the-pitcher-plant-cephalotus-reveals-genetic-changes-associated-with-carnivory
#12
Kenji Fukushima, Xiaodong Fang, David Alvarez-Ponce, Huimin Cai, Lorenzo Carretero-Paulet, Cui Chen, Tien-Hao Chang, Kimberly M Farr, Tomomichi Fujita, Yuji Hiwatashi, Yoshikazu Hoshi, Takamasa Imai, Masahiro Kasahara, Pablo Librado, Likai Mao, Hitoshi Mori, Tomoaki Nishiyama, Masafumi Nozawa, Gergő Pálfalvi, Stephen T Pollard, Julio Rozas, Alejandro Sánchez-Gracia, David Sankoff, Tomoko F Shibata, Shuji Shigenobu, Naomi Sumikawa, Taketoshi Uzawa, Meiying Xie, Chunfang Zheng, David D Pollock, Victor A Albert, Shuaicheng Li, Mitsuyasu Hasebe
Carnivorous plants exploit animals as a nutritional source and have inspired long-standing questions about the origin and evolution of carnivory-related traits. To investigate the molecular bases of carnivory, we sequenced the genome of the heterophyllous pitcher plant Cephalotus follicularis, in which we succeeded in regulating the developmental switch between carnivorous and non-carnivorous leaves. Transcriptome comparison of the two leaf types and gene repertoire analysis identified genetic changes associated with prey attraction, capture, digestion and nutrient absorption...
February 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811909/a-fourth-subtype-of-retinoic-acid-receptor-related-orphan-receptors-is-activated-by-oxidized-all-trans-retinoic-acid-in-medaka-oryzias-latipes
#13
Kotowa Sakai, Haruka Fukushima, Yuya Yamamoto, Toshitaka Ikeuchi
BACKGROUND: The three known subtypes of the retinoic acid receptor-related orphan receptor (ROR) have been implicated in the control of immunity, brain function, and circadian rhythm in mammals. Here, we demonstrate by phylogenetic analysis that there were originally four subtypes of RORs in vertebrates. One of the novel ror paralogs, rord1 (rorca in the Ensembl database), is conserved among teleosts, but absent in mammals. Using medaka (Oryzias latipes) as a model teleost, we evaluated the expression pattern of this gene, its transactivational properties for endogenic chemicals, and its ability to activate the promoters of putative target genes...
2017: Zoological Letters
https://www.readbyqxmd.com/read/28811855/impact-of-the-great-east-japan-earthquake-and-fukushima-nuclear-power-plant-accident-on-assisted-reproductive-technology-in-fukushima-prefecture-the-fukushima-health-management-survey
#14
Masako Hayashi, Keiya Fujimori, Seiji Yasumura, Akihito Nakai
BACKGROUND: The aim of the study was to evaluate the incidences and obstetric outcomes of women who conceived using assisted reproductive technology (ART) procedures in Fukushima Prefecture before and after the Great East Japan Earthquake and Fukushima nuclear power plant accident. METHODS: Information was collected and analyzed from 12,070 women who conceived with or without ART in Fukushima Prefecture during the 9 months before and after the disaster. RESULTS: During the 9 months before and after the disaster, 138 (2...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811510/temporal-changes-in-the-radiocesium-distribution-in-forests-over-the-five-years-after-the-fukushima-daiichi-nuclear-power-plant-accident
#15
Naohiro Imamura, Masabumi Komatsu, Shinta Ohashi, Shoji Hashimoto, Takuya Kajimoto, Shinji Kaneko, Tsutomu Takano
To elucidate the temporal changes in the radiocesium distribution in forests contaminated by the Fukushima Daiichi Nuclear Power Plant accident, we monitored the (137)Cs concentration and inventory within forests from 2011 to 2015 across nine plots containing variable tree species and different contamination levels. The (137)Cs concentrations in needles and branches decreased exponentially at all coniferous plots, with effective ecological half-lives of 0.45-1.55 yr for needles and 0.83-1.69 yr for branches...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808579/a-novel-bbs10-mutation-identified-in-a-patient-with-bardet-biedl-syndrome-with-a-violent-emotional-outbreak
#16
Tatsuyuki Ohto, Takashi Enokizono, Ryuta Tanaka, Mai Tanaka, Hisato Suzuki, Aiko Sakai, Kazuo Imagawa, Hiroko Fukushima, Takashi Fukushima, Ryo Sumazaki, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki
We report a 10-year-old girl with Bardet-Biedl syndrome caused by a novel mutation in the Bardet-Biedl syndrome 10 (BBS10) gene. She had multiple malformations, including a dysmorphic face, postaxial polydactyly, polycystic kidney and amblyopia. She presented with typical BBS features, including intellectual disability with emotional outbursts and mild obesity. Whole-exome sequencing identified compound heterozygous mutations with NM_024685.3:c.1677C>A [p.(Tyr559*)] and c.1974T>G [p.(Tyr658*)]. To our knowledge, the latter mutation has never been reported previously...
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28808017/antitumor-effect-of-batf2-through-il-12-p40-up-regulation-in-tumor-associated-macrophages
#17
Hisashi Kanemaru, Fumihiro Yamane, Kiyoharu Fukushima, Takanori Matsuki, Takahiro Kawasaki, Isao Ebina, Kanako Kuniyoshi, Hiroki Tanaka, Kenta Maruyama, Kazuhiko Maeda, Takashi Satoh, Shizuo Akira
The development of effective treatments against cancers is urgently needed, and the accumulation of CD8(+) T cells within tumors is especially important for cancer prognosis. Although their mechanisms are still largely unknown, growing evidence has indicated that innate immune cells have important effects on cancer progression through the production of various cytokines. Here, we found that basic leucine zipper transcription factor ATF-like 2 (Batf2) has an antitumor effect. An s.c. inoculated tumor model produced fewer IL-12 p40(+) macrophages and activated CD8(+) T cells within the tumors of Batf2(-/-) mice compared with WT mice...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807451/the-137-cs-activity-concentration-of-suspended-and-dissolved-fractions-in-irrigation-waters-collected-from-the-80%C3%A2-km-zone-around-tepco-s-fukushima-daiichi-nuclear-power-station
#18
Hirofumi Tsukada, Satoshi Nihira, Takashi Watanabe, Satoru Takeda
Fifty-four samples of irrigation water were collected in 2014 from agricultural ponds, rivers, and dams within the 80 km zone around TEPCO's Fukushima Daiichi Nuclear Power Station (FDNPS). The samples were filtered with a 0.45 μm pore-size membrane filter to produce suspended and dissolved fractions. The (137)Cs activity concentration of the suspended fraction varied from 1.5 to 300 Bq g(-1) dry weight and was significantly higher than that in the soil around each sampling site. The range of (137)Cs activity concentrations in the dissolved fraction varied over three orders of magnitude at 0...
August 11, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28806596/development-of-an-effective-dose-coefficient-database-using-a-computational-human-phantom-and-monte-carlo-simulations-to-evaluate-exposure-dose-for-the-usage-of-norm-added-consumer-products
#19
Do Hyeon Yoo, Wook-Geun Shin, Jaekook Lee, Yeon Soo Yeom, Chan Hyeong Kim, Byung-Uck Chang, Chul Hee Min
After the Fukushima accident in Japan, the Korean Government implemented the "Act on Protective Action Guidelines Against Radiation in the Natural Environment" to regulate unnecessary radiation exposure to the public. However, despite the law which came into effect in July 2012, an appropriate method to evaluate the equivalent and effective doses from naturally occurring radioactive material (NORM) in consumer products is not available. The aim of the present study is to develop and validate an effective dose coefficient database enabling the simple and correct evaluation of the effective dose due to the usage of NORM-added consumer products...
August 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28804981/lipopolysaccharide-inhibits-hepatic-gluconeogenesis-in-rats-the-role-of-immune-cells
#20
Hiroshi Tanaka, Yoshikazu Nishikawa, Toru Fukushima, Ataru Taniguchi, Yoshihito Fujita, Kinsuke Tsuda, Nobuya Inagaki, Masaya Hosokawa
AIMS/INTRODUCTION: Bacterial septicemia has diverse clinical symptoms including severe hypoglycemia. However, sepsis-induced hypoglycemia has not yet been examined in detail. The aim of the present study is to investigate the mechanisms underlying hypoglycemia in sepsis. MATERIALS AND METHODS: We induced endotoxin shock in rats using lipopolysaccharide (LPS). After an intraperitoneal injection of LPS, we measured gluconeogenesis using the pyruvate tolerance test (PTT)...
August 14, 2017: Journal of Diabetes Investigation
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