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Hirosumi Tamura, Arisa Higa, Hirotaka Hoshi, Gen Hiyama, Nobuhiko Takahashi, Masae Ryufuku, Gaku Morisawa, Yuka Yanagisawa, Emi Ito, Jun-Ichi Imai, Yuu Dobashi, Kiyoaki Katahira, Shu Soeda, Takafumi Watanabe, Keiya Fujimori, Shinya Watanabe, Motoki Takagi
Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture and function. PDOs were able to be cultured for >6 months, and formed cell clusters with similar morphologies to their source tumors...
June 18, 2018: Oncology Reports
A Young J Park, Joshua Wang, Jordanna Jayne, Lynn Fukushima, Adupa P Rao, David Z D'Argenio, Paul M Beringer
Over the past decade, the prevalence of infections involving Methicillin-resistant Staphylococcus aureus (MRSA) in patients with cystic fibrosis (CF) has increased significantly. Tedizolid (TZD) demonstrates excellent activity against MRSA and a favorable safety profile. The pharmacokinetics of several antibiotics has shown to be altered in CF patients. The purpose of this study was to characterize the pharmacokinetics of tedizolid in this population. Eleven patients with CF were randomized to receive tedizolid phosphate 200 mg PO or IV once daily for 3 doses, with minimum 2-day washout, followed by crossover to the remaining dosage form...
June 18, 2018: Antimicrobial Agents and Chemotherapy
Peng Yi, Xuegao Chen, Zixia Wang, Ala Aldahan, Xiaolin Hou, Zhongbo Yu
The radioactive isotope 129 I, with a half-life of 1.57 × 107 years, is widely used as a tracer to assess nuclear safety, to track environmental and geological events and to figure out the details of the stable iodine geochemical cycle. This work investigated the 129 I and 127 I distribution in water samples collected from the terrestrial (rivers, lakes and springs) and marine water systems (estuary and sea) in China. The measured 129 I concentrations of (1-51) × 106 atoms/L and 129 I/127 I ratios of (0...
June 14, 2018: Journal of Environmental Radioactivity
Chikako Hara, Taku Wakabayashi, Hiroshi Toyama, Yoko Fukushima, Kaori Sayanagi, Shigeru Sato, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate the frequency and patient characteristics that influence anatomic response of intravitreal aflibercept in treatment-naïve neovascular age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, consecutive case series. METHODS: Three hundred and sixty-five eyes of 365 patients with AMD who underwent 3 monthly intravitreal aflibercept treatments with follow-up for at least 12 months were investigated...
June 15, 2018: British Journal of Ophthalmology
Katsuhiro Masago, Kei Irie, Shiro Fujita, Fumiko Imamichi, Yutaka Okada, Nobuyuki Katakami, Shoji Fukushima, Yasushi Yatabe
PURPOSE: The purpose of the study was to evaluate the site of paronychia in patients with non-small cell lung cancer harboring an epidermal growth factor receptor (EGFR) gene activating mutation who were treated with EGFR tyrosine kinase inhibitors (EGFR TKIs). PATIENTS AND METHODS: The study included 55 patients with non-small-cell lung cancer who were treated with an EGFR TKIs. Resulting all toxicities were graded using the Common Terminology Criteria for Adverse Events version 4...
June 14, 2018: Oncology
Xin Guo, Jiro Watanabe, Sanae Ariyasu, Yasuyuki Sasaguri, Nozomu Kurose, Kei Fukushima, Sohsuke Yamada
An 80-year-old male presented with a history of a hard right parotid mass that had gradually increased in size, with subsequent facial paralysis. A fine-needle aspiration biopsy was performed. The cytologic specimens contained a substantial number of sheet-like clusters or small groups of a mixture of plasmacytoid, oval to spindled, or large epithelioid cells having hyperchromatic pleomorphic nuclei, abundant cytoplasm with occasional inclusion body-like materials, and prominent nucleoli, in a relatively clear background...
2018: SAGE Open Medical Case Reports
Teruhisa Higuchi, Mitsuhiko Moriyama, Akiko Fukushima, Hiroshi Matsumura, Shunichi Matsuoka, Tatsuo Kanda, Masahiko Sugitani, Akiko Tsunemi, Takahiro Ueno, Noboru Fukuda
Background: Excess iron is associated with non-alcoholic steatohepatitis (NASH). Results: mRNA expression of duodenal cytochrome b, divalent metal transporter 1, ferroportin 1, hepcidin, hephaestin and transferrin receptor 1 in liver were higher in high fat, high cholesterol-containing diet (HFCD) group than in normal diet (ND) group. mRNA levels of divalent metal transporter 1 and transferrin receptor 1, which stimulate iron absorption and excretion, were enhanced in small intestine...
May 25, 2018: Oncotarget
Yu-Syuan Luo, Shinji Furuya, Valerie Y Soldatov, Oksana Kosyk, Hong Sik Yoo, Hisataka Fukushima, Lauren Lewis, Yasuhiro Iwata, Ivan Rusyn
Trichloroethylene (TCE) and tetrachloroethylene (PCE) are structurally similar olefins that can cause liver and kidney toxicity. Adverse effects of these chemicals are associated with metabolism to oxidative and glutathione conjugation moieties. It is thought that CYP2E1 is crucial to the oxidative metabolism of TCE and PCE, and may also play a role in formation of nephrotoxic metabolites; however, inter-species and inter-individual differences in contribution of CYP2E1 to metabolism and toxicity are not well understood...
April 20, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Yasuyo Fukushi, Ayumi Nakamura, Chieko Itaki, Shinji Tokonami, Masatoshi Yamada, Yasushi Mariya
Following the accident at the Fukushima Daiichi Nuclear Power Plant in 2011, a number of evacuees were forced to live in temporary housing and suffered mental and physical stress. However, few reports have used objective or quantitative indicators to determine the evacuee's level of stress. The aim of the present study was to serially estimate the mental and physical stress of the evacuees from 2013 to 2015 by using the oxidative stress marker, urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). A total of 773 evacuees from Namie town in Fukushima prefecture participated in the study...
July 2018: Experimental and Therapeutic Medicine
Yosuke Wada, Yoshiaki Kitaguchi, Masanori Yasuo, Fumika Ueno, Satoshi Kawakami, Kiyoyasu Fukushima, Keisaku Fujimoto, Masayuki Hanaoka
Introduction: This study was conducted in order to investigate the diversity of respiratory physiology, including the respiratory impedance and reversibility of airway obstruction, based on quantitative computed tomography (CT) in patients with COPD. Patients and methods: Medical records of 174 stable COPD patients were retrospectively reviewed to obtain the patients' clinical data, including the pulmonary function and imaging data. According to the software-based quantification of the degree of emphysema and airway wall thickness, the patients were classified into the "normal by CT" phenotype, the airway-dominant phenotype, the emphysema-dominant phenotype, and the mixed phenotype...
2018: International Journal of Chronic Obstructive Pulmonary Disease
Yuriko Suzuki, Yoshitake Takebayashi, Seiji Yasumura, Michio Murakami, Mayumi Harigane, Hirooki Yabe, Tetsuya Ohira, Akira Ohtsuru, Satomi Nakajima, Masaharu Maeda
After the Fukushima nuclear power plant accident, numerous evacuees reported poor mental health status and high-risk perceptions of the health effects of radiation. However, the temporal associations between these variables have not yet been examined. Using data from the Fukushima Health Survey, we examined changes in risk perception of the health effects of radiation over time and assessed the effects of mental health on such changes using logistic regression analysis. Risk perception for delayed effect pertains a brief on health effect in later life (delayed effect), whereas that of genetic effect pertains a brief on health effect of future children and grandchildren (genetic effect)...
June 10, 2018: International Journal of Environmental Research and Public Health
Kyuma Suzuki, Shun Watanabe, Yumi Yuasa, Yasunori Yamashita, Hajime Arai, Hideki Tanaka, Toshihiro Kuge, Masanobu Mori, Kin-Ichi Tsunoda, Seiichi Nohara, Yuichi Iwasaki, Yoshitaka Minai, Yukiko Okada, Seiya Nagao
Understanding ecosystem dynamics of radionuclides is necessary to ensure effective management for food safety. The Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011 released large amounts of radiocesium (134 Cs and 137 Cs) and contaminated the environment across eastern Japan. In this study, we aimed to elucidate the temporal dynamics of 137 Cs in the aquatic ecosystem of Lake Onuma on Mt. Akagi. The effective ecological half-life (Teff ) of 137 Cs in fishes, western waterweed (Elodea nuttallii), seston (phytoplankton and zooplankton), and lake water was estimated using survey data of 137 Cs concentration collected from 2011 to 2016, and single- and two-component decay function models (SDM and TDM, respectively)...
May 1, 2018: Science of the Total Environment
Mochamad Adhiraga Pratama, Minoru Yoneda, Yosuke Yamashiki, Yoko Shimada, Yasuto Matsui
The Fukushima Dai-ichi nuclear power plant accident released radiocesium in large amounts. The released radionuclides contaminated much of the surrounding environment, including sewers in urban areas of Fukushima prefecture. In this study we attempted to identify and quantify the sources of radiocesium contamination in separate sewerage systems and developed a compartment model based on the Radionuclide Migration in Urban Environments and Drainage Systems (MUD) model. Measurements of the time-dependent radiocesium concentration in sewer sludge combined with meteorological, demographic, and radiocesium dietary intake data indicated that rainfall-derived inflow and infiltration (RDII) and human excretion were the chief contributors of radiocesium contamination in a separate sewerage system...
May 1, 2018: Science of the Total Environment
Yukiyoshi Hyo, Hisaki Fukushima, Tamotsu Harada, Hirotaka Hara
Although nasal septal abscess (NSA) was formerly common, it has become rare since the development of antibiotics. NSA, if left untreated, can lead to intracranial complications such as meningitis and eventually result in saddle-nose deformity. NSA often occurs after injury, and indigenous skin bacteria such as Staphylococcus aureus are frequently detected. We treated a patient who had injured the upper alveolus in a fall on the stairs and developed NSA two weeks later. Anaerobic bacteria, including Veillonella parvula and Peptostreptococcus sp...
June 7, 2018: Auris, Nasus, Larynx
Atsushi Kubo, Kai Tanabe, Genta Suzuki, Yukari Ito, Takashi Ishimaru, Nobue Kasamatsu-Takasawa, Daisuke Tsumune, Takuji Mizuno, Yutaka W Watanabe, Hisayuki Arakawa, Jota Kanda
Radioactive cesium concentrations in the suspended matter of the coastal waters around the Fukushima Daiichi Nuclear Power Plant (FDNPP) were investigated between January 2014 and August 2015. The concentrations of radioactive cesium in the suspended matter were two orders higher in magnitude than those determined in the sediment. In addition, we discovered highly radioactive Cs particles in the suspended matter using autoradiography. The geometrical average radioactivity of particles was estimated to be 0...
June 2018: Marine Pollution Bulletin
Peng Zhou, Dongmei Li, Li Zhao, Haitao Li, Feng Zhao, Yuanlai Zheng, Hongda Fang, Quansheng Lou, Weixu Cai
To understand the impact of the Fukushima nuclear accident (FNA), 137 Cs, 134 Cs, 90 Sr, and gross beta were analyzed in the northeast South China Sea (NSCS), the Luzon Strait (LS) and its adjacent areas. 137 Cs, 90 Sr, and gross beta values in the NSCS were similar to those prior to the FNA. 90 Sr and 137 Cs in the LS and its adjacent areas were consistent with those in the NSCS. The high 137 Cs-peak values occurred at depth of 150 m whereas the high 90 Sr-peak values occurred at depth of 0.5 m. The 137 Cs and gross beta mean values in Cruise I were higher than those in Cruise II whereas the 90 Sr mean value was just the reverse...
June 2018: Marine Pollution Bulletin
Junting Zang, Katsufumi Uchiyama, Mitsutoshi Moriya, Zhengwei Li, Kensuke Fukushima, Takeaki Yamamoto, Jianguo Liu, Wei Feng, Naonobu Takahira, Masashi Takaso
Intracapsular cuneiform osteotomy was initially introduced to restore the morphology of the proximal femur after slipped capital femoral epiphysis (SCFE). However, whether this procedure results in a higher risk of avascular necrosis (AVN) or lower incidence of cam deformity than in-situ pinning is unclear. The aim of this study was to compare the outcomes of intracapsular cuneiform osteotomy and in-situ pinning to treat SCFE in children. Twenty-three children who suffered from SCFE underwent either intracapsular cuneiform osteotomy (eight patients, eight hips) or in-situ pinning (15 patients, 18 hips) between 2006 and 2014...
June 1, 2018: Journal of Pediatric Orthopedics. Part B
Sayaka Kawashima, Akie Nakamura, Takanobu Inoue, Keiko Matsubara, Reiko Horikawa, Keiko Wakui, Kyoko Takano, Yoshimitsu Fukushima, Toshi Tatematsu, Seiji Mizuno, Junko Tsubaki, Shigeo Kure, Yoichi Matsubara, Tsutomu Ogata, Maki Fukami, Masayo Kagami
Context: Maternal uniparental disomy for chromosome 20 [UPD(20)mat], resulting in aberrant expression of imprinted transcripts at the GNAS locus, is a poorly characterized condition. These patients manifested a phenotype similar to that of Silver-Russell syndrome (SRS) and small for gestational age-short stature (SGA-SS); however, the etiological relationship between UPD(20)mat and SRS/SGA-SS remains unclear. Moreover, no report has described endocrinological assessment of UPD(20)mat patients, although paternal UPD(20), the mirror image entity of UPD(20)mat, is known to cause multiple hormone resistance reflecting reduced α-subunit of the stimulatory G protein expression...
June 1, 2018: Journal of Clinical Endocrinology and Metabolism
Takashi Horie, Seiji Yamazaki, Sayaka Hanada, Shuzo Kobayashi, Tatsuo Tsukamoto, Tetsuya Haruna, Katsuhiko Sakaguchi, Ken Sakai, Hideaki Obara, Kiyofumi Morishita, Kenichi Saigo, Yoshiaki Shintani, Kohmei Kubo, Junichi Hoshino, Teiji Oda, Eiji Kaneko, Masaharu Nishikido, Tetsuya Ioji, Hideaki Kaneda, Masanori Fukushima
BACKGROUND: The clinical usefulness of peripheral blood (PB) mononuclear cell (MNC) transplantation in patients with peripheral arterial disease (PAD), especially in those with mild-to-moderate severity, has not been fully clarified.Methods and Results:A randomized clinical trial was conducted to evaluate the efficacy and safety of granulocyte colony-stimulating factor (G-CSF)-mobilized PBMNC transplantation in patients with PAD (Fontaine stage II-IV and Rutherford category 1-5) caused by arteriosclerosis obliterans or Buerger's disease...
June 7, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
D J Horne, B E Jones, A Kamada, K Fukushima, K L Winthrop, S A R Siegel, A Kovacs, P Anthony, K A Meekin, S Bhat, P Kerndt, A Chang, D M Koelle, M Narita
SETTING: QuantiFERON®-TB Gold Plus (QFT-Plus), recently approved for use in the United States, is a new-generation QuantiFERON assay that differs from its predecessors in that it uses an additional antigen tube containing peptides to elicit both CD8+ and CD4+ T-lymphocyte responses. OBJECTIVE: To assess the sensitivity of QFT-Plus compared with QuantiFERON®-TB Gold In-Tube (QFT-GIT) in participants with active TB. DESIGN: Adult patients with active TB at three US and two Japanese sites were eligible for this study if they had culture-confirmed TB and were either untreated or had received 14 days of anti-tuberculosis treatment...
June 1, 2018: International Journal of Tuberculosis and Lung Disease
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