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https://www.readbyqxmd.com/read/29442432/investigation-of-corneal-endothelial-changes-post-selective-laser-trabeculoplasty
#1
Kate E Leahy, Michele C Madigan, Maria Sarris, Stephanie L Watson, Peter McCluskey, Andrew Jr White
IMPORTANCE: Transient corneal endothelial changes are routinely noted on slit-lamp examination immediately following selective laser trabeculoplasty (SLT). BACKGROUND: To determine the mechanism of the transient corneal endothelial changes observed following SLT. DESIGN: University laboratory based observational study SAMPLES: Ten corneas from six human cadaveric donors. METHODS: Corneas were treated with SLT, direct laser, or peroxide, or used as controls...
February 14, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29438122/corneal-and-anterior-chamber-morphology-in-human-immunodeficiency-virus-1-infected-patients-without-opportunistic-infections
#2
Ebru N Cetin, Selda Sayın Kutlu, Osman Parca, Murat Kutlu, Gökhan Pekel
OBJECTIVES: To evaluate corneal and anterior chamber morphology as measured by Pentacam HR in human immunodeficiency virus (HIV)-infected patients without opportunistic infections and to search for signs of accelerated aging. METHODS: This prospective study included 41 eyes of 41 HIV-1-infected patients (study group) and 50 eyes of 50 healthy subjects (control group). Specular microscope and Pentacam HR were used for corneal and anterior chamber morphology evaluation...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29434243/isolation-and-expansion-of-multipotent-progenitors-from-human-trabecular-meshwork
#3
Yuan Zhang, Subo Cai, Scheffer C G Tseng, Ying-Ting Zhu
To expand multi-potent progenitors from human trabecular meshwork (TM), we have created a new optimized method on two-dimensional (2D) followed by three-dimensional (3D) Matrigel in modified embryonic stem cell medium supplemented with 5% fetal bovine serum (MESCM + 5% FBS). The expanded TM cells were small cuboidal cells expressing TM markers such as AQP1, MGP, CHI3L1, and AnkG, embryonic stem cell (ESC) markers such as Oct4, Sox2, Nanog, and ABCG2, and neural crest (NC) markers such as p75NTR, FOXD3, Sox9, Sox10, and MSX1...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29430874/characterizing-human-decellularized-crystalline-lens-capsules-as-a-scaffold-for-corneal-endothelial-tissue-engineering
#4
Bert Van den Bogerd, Sorcha Ní Dhubhghaill, Nadia Zakaria
The idea of transplanting a sheet of laboratory-grown corneal endothelium dates back to 1978; however, the ideal scaffold is still lacking. We hypothesized that human crystalline lens capsules (LCs) could qualify as a scaffold and aimed to characterize the properties of this material for endothelial tissue engineering. LCs were isolated from donor eyes, stored at -80 °C, and decellularized with water and trypsin-EDTA. The decellularization was investigated by nuclear staining and counting and the capsule thickness was determined by optical coherence tomography and compared with Descemet's membrane (DM)...
December 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29429294/-pre-descement-membrane-endothelial-keratoplasty-for-treatment-of-patients-with-corneal-endothelial-decompensation
#5
T Huang, L Jiang, J Zhan, C Ouyang
Objective: To investigate the clinical outcomes of Pre-descement membrane endothelial keratoplasty (PDEK) for treatment of patients with corneal endothelial decompensation. Methods: Retrospective study of case series. The cases of 20 patients (20 eyes) who were diagnosed with corneal endothelial decompensation induced by various original diseases and received PDEK during July 2016 and December 2016 at Zhongshan Ophthalmic Center have been analyzed. The participants included 8 males and 12 females with an average age of (59...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429293/-deep-anterior-lamellar-keratoplasty-combined-with-antiviral-therapy-in-the-treatment-of-severe-herpes-necrotizing-stromal-keratitis
#6
S X Li, J T Wang, Y Jiang, X Wang, W Y Shi
Objective: To evaluate the efficacy of modified deep lamellar keratoplasty (DLKP) combined with antiviral medications for severe herpes necrotizing stromal keratitis. Methods: Retrospective case series study. Modified DLKP was performed in combination with antiviral medications in fifty patients (50 eyes) with severe necrotizing stromal keratitis, which was unresponsive to systemic and topical antiviral treatment for 1 week, at Shandong Eye Hospital. Before surgery, the operated eyes were examined using slit-lamp microscopy...
February 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29429150/mir-199a-b-5p-inhibits-lymphangiogenesis-by-targeting-discoidin-domain-receptor-1-in-corneal-injury
#7
Sooeun Oh, Minkoo Seo, Jun-Sub Choi, Choun-Ki Joo, Suk Kyeong Lee
Discoidin domain receptor 1 (DDR1) is involved in tumorigenesis and angiogenesis. However, its role in lymphangiogenesis has been unknown. Here, we tested whether downregulation of DDR1 expression by miR-199a/b can suppress lymphangiogenesis. We also aimed to identify miRNA target site(s) in the 3' untranslated region (UTR) of DDR1. Transfection with miR-199a/b-5p mimics reduced expression of DDR1 and tube formation in primary human dermal lymphatic endothelial cells, whereas miR-199a/b-5p inhibitors showed the opposite effects...
February 2, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29422766/inhibition-of-yap-ameliorates-choroidal-neovascularization-via-inhibiting-endothelial-cell-proliferation
#8
Zhenzhen Yan, Haihong Shi, Rongrong Zhu, Lele Li, Bai Qin, Lihua Kang, Hui Chen, Huaijin Guan
Purpose: Age-related macular degeneration (AMD) is the leading cause of central visual loss among patients over the age of 55 years worldwide. Neovascular-type AMD (nAMD) accounts for approximately 10% of patients with AMD and is characterized by choroidal neovascularization (CNV). The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29422758/localized-trichiasis-causing-focal-full-thickness-corneal-edema-endothelial-cell-loss-and-corneal-scarring-requiring-penetrating-keratoplasty
#9
Tiffany Sara Liu, Seth Meskin
The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Specular microscopy showed diffuse endothelial cell loss. He was treated with topical steroids and acyclovir with epilation of lashes. Anterior chamber paracentesis was negative for varicella-zoster virus, cytomegalovirus, and herpes simplex virus...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29422754/comparative-evaluation-of-corneal-endothelium-in-diabetic-patients-undergoing-phacoemulsification
#10
Pramod Kumar Sahu, Gopal Krushna Das, Sumeet Agrawal, Sabitabh Kumar, Nitish Kumar
PURPOSE: To determine if phacoemulsification with intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients as compared to nondiabetics. MATERIALS AND METHODS: This study compared the endothelial status in 60 diabetics with good glycemic control and 60 nondiabetics before and after uneventful phacoemulsification. Central corneal endothelial cell density, percentage hexagonality and percentage coefficient of variation (%CV) were measured using a specular microscope...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29413615/functionalized-silk-fibroin-film-scaffold-using-%C3%AE-carotene-for-cornea-endothelial-cell-regeneration
#11
Do Kyung Kim, Bo Ra Sim, Jeong In Kim, Gilson Khang
Design of corneal endothelium substitute is important for replacement of cadaveric cornea tissue. Our previous study has shown the suitability of silk fibroin (SF) as a biomaterial for cornea scaffold. In this study, we used β-Carotene (β-C) to enhance the regeneration of corneal endothelial cells (CEnCs) and maintain CEnC specific function. The fabricated film scaffolds showed desired transparency and hydrophilic properties which are crucial factors for vision recovery. The cell viability, phenotype and gene expression was examined using MTT assay, immunofluorescence and reverse transcription polymerase chain reactions...
November 22, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29411172/effect-of-laser-peripheral-iridotomy-using-argon-and-neodymium-yag-lasers-on-corneal-endothelial-cell-density-7-year-longitudinal-evaluation
#12
Takashi Ono, Masaharu Iida, Toshihiro Sakisaka, Keiichiro Minami, Kazunori Miyata
PURPOSE: To evaluate the changes in corneal endothelial cell density (ECD) over a 7-year period after laser peripheral iridotomy (LPI) using argon and neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers. STUDY DESIGN: Retrospective case series. METHODS: Eyes that underwent prophylactic LPI using argon and Nd:YAG lasers were followed up for 7 years. Central corneal endothelial cells were observed by use of noncontact specular microscopy preoperatively and at 1 and 7 years postoperatively...
February 6, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29410297/trends-in-corneal-transplantation-from-2001-to-2016-in-germany-a-report-of-the-dog-section-cornea-and-its-keratoplasty-registry
#13
E Flockerzi, P Maier, D Böhringer, H Reinshagen, F Kruse, C Cursiefen, T Reinhard, G Geerling, N Torun, B Seitz
PURPOSE: The purpose of this retrospective panel study was to provide an overview of absolute numbers, trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016. METHODS: A questionnaire about absolute numbers, types of transplantation and indications was sent to 111 ophthalmological departments in Germany out of which 94 (85%) provided their data. RESULTS: Since the year 2001, the number of corneal transplantations has increased by 1...
February 1, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29408830/selective-endothelial-removal-for-peters-anomaly
#14
Yu Qiang Soh, Jodhbir S Mehta
PURPOSE: Peters anomaly is the most common cause of congenital corneal opacities. Although conservative management is often ineffective except in mild cases, surgical intervention in the form of penetrating keratoplasty is fraught with unpredictability and often has unacceptable postoperative outcomes. As such, there is a need to explore alternative surgical interventions that may possibly improve the postoperative visual prognosis in these patients. In this report, we present a case of type 1 Peters anomaly treated by selective endothelial removal without corneal tissue transplantation...
March 2018: Cornea
https://www.readbyqxmd.com/read/29408827/corneal-optical-changes-associated-with-induced-edema-in-fuchs-endothelial-corneal-dystrophy
#15
Katrin Wacker, Jay W McLaren, Katrina M Kane, Sanjay V Patel
PURPOSE: Patients with Fuchs endothelial corneal dystrophy (FECD) often notice poor vision in the morning that improves as the day progresses. In this study, we determined changes in corneal optical properties associated with induced corneal edema. METHODS: Twenty-three phakic eyes (23 participants) with FECD (grades 1-6, modified Krachmer scale) and 8 normal eyes (8 participants) were examined by Scheimpflug photography. Central corneal thickness, high-order aberrations from anterior and posterior corneal surfaces, and backscatter from the anterior, mid-, and posterior cornea were determined from the Scheimpflug images...
March 2018: Cornea
https://www.readbyqxmd.com/read/29406793/development-and-evaluation-of-a-novel-microemulsion-of-dexamethasone-and-tobramycin-for-topical-ocular-administration
#16
Rinda Devi Bachu, Marina Stepanski, Rami M Alzhrani, Rose Jung, Sai H S Boddu
PURPOSE: The purpose of this study was to develop and evaluate a novel dexamethasone- and tobramycin-loaded microemulsion for its potential for treating anterior segment eye infections. METHODS: The microemulsion was evaluated for pH, particle size, zeta potential, light transmittance, morphology, and in vitro drug release. Sterility of the microemulsion was evaluated by direct as well as plate inoculation methods. Anti-inflammatory activity of dexamethasone, bactericidal activity of tobramycin, and cytotoxicity of the microemulsion were assessed and compared to that of the marketed eye drop suspension (Tobradex®)...
February 6, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29401122/corneal-endothelial-tolerance-after-iris-fixated-phakic-intraocular-lens-implantation-a-model-to-predict-endothelial-cell-survival
#17
Sabrina Chebli, Muriel Rabilloud, Carole Burillon, Viridiana Kocaba
PURPOSE: To evaluate the long-term endothelial tolerance of iris-fixated phakic intraocular lenses (pIOLs) over a 10-year period, to identify predictive factors for endothelial decompensation, and to develop a model to predict endothelial cell survival after pIOL implantation. METHODS: This retrospective study included 130 eyes in 60 patients who underwent pIOL implantation for correction of high myopia from January 2003 to October 2012 at Edouard Herriot Hospital in Lyon, France...
February 2, 2018: Cornea
https://www.readbyqxmd.com/read/29398334/visual-quality-with-corneo-scleral-contact-lenses-for-keratoconus-management
#18
Juan Carlos Montalt, Esteban Porcar, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: To assess the visual quality achieved by fitting corneo-scleral contact lenses (CScL) for keratoconus management. METHODS: Thirty patients with keratoconus presented to have CScL fitted because of the unsatisfactory visual quality they experienced with their contact lenses or spectacles. The eye examination included visual acuity assessment, anterior eye biomicroscopy, ocular fundus examination, corneal topographic analysis, endothelial-cell count, contrast sensitivity and aberrometry...
February 2, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29394897/a-dose-escalation-ex-vivo-study-on-the-effects-of-intracameral-benzalkonium-chloride-in-rabbits
#19
Sergi Segarra, Marta Leiva, Daniel Costa, Natàlia Coyo, Maria Sabés-Alsina, José Ríos, Teresa Peña
BACKGROUND: Rabbits are currently not a good model for studying diseases of the corneal endothelium because their corneal endothelial cells (CECs) maintain a high proliferative capacity throughout almost all their life. Addressing this particular feature might allow the use of this species for such a purpose. The aim of this study was to evaluate the corneal endothelial injury after intracameral benzalkonium chloride (BAC) injection into rabbit eyes ex vivo, and to establish the most suitable starting dose for an in vivo study aimed at developing an animal model of corneal endothelial disease...
February 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29392640/corneal-incision-architecture-after-iol-implantation-with-three-different-injectors-an-environmental-scanning-electron-microscopy-study
#20
Rita Mencucci, Eleonora Favuzza, Maria Cristina Salvatici, Leopoldo Spadea, David Allen
PURPOSE: To evaluate by Environmental Scanning Electron Microscopy (ESEM) the corneal incision architecture after intraocular lens (IOL) implantation in pig eyes, using manual, automated injectors or preloaded delivery systems. METHODS: Twenty-four pig eyes underwent IOL implantation in the anterior chamber using three different injectors: manual (Monarch III) (n = 8), automated (AutoSert) (n = 8), or a preloaded system (UltraSert) (n = 8). Acrysof IQ IOLs, 21 Dioptres (D) (n = 12) and 27D (n = 12), were implanted through 2...
February 1, 2018: International Ophthalmology
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