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Corneal endotheliitis

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https://www.readbyqxmd.com/read/29024692/the-role-of-hepatocyte-growth-factor-in-corneal-wound-healing
#1
REVIEW
Hidetaka Miyagi, Sara M Thomasy, Paul Russell, Christopher J Murphy
Hepatocyte growth factor (HGF) is a glycoprotein produced by mesenchymal cells and operates as a key molecule for tissue generation and renewal. During corneal injury, HGF is primarily secreted by stromal fibroblasts and promotes epithelial wound healing in a paracrine manner. While this mesenchymal-epithelial interaction is well characterized in various organs and the cornea, the role of HGF in corneal stromal and endothelial wound healing is understudied. In addition, HGF has been shown to play an anti-fibrotic role by inhibiting myofibroblast generation and subsequent production of a disorganized extracellular matrix and tissue fibrosis...
October 9, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29023312/prediction-of-descemet-membrane-perforation-during-deep-anterior-lamellar-keratoplasty-in-patients-with-keratoconus-with-stromal-scar
#2
Mehmet Cuneyt Ozmen, Nilufer Yesilirmak, Bahri Aydin, Kubra Serbest Ceylanoglu, Hatice Tuba Atalay, Fikret Akata
OBJECTIVES: To report big-bubble deep anterior lamellar keratoplasty (DALK) in patients with keratoconus with corneal stromal scar, and to investigate factors that can influence intraoperative Descemet membrane (DM) perforation. METHODS: A retrospective study included patients with keratoconus with central stromal scar that underwent DALK using the big-bubble technique. Best spectacle-corrected visual acuity (BSCVA), keratometry, minimum corneal thickness (MCT), stromal scar depth, and endothelial cell density (ECD) were recorded...
October 11, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29022296/efficacy-and-safety-of-intracameral-bevacizumab-for-treatment-of-neovascular-glaucoma
#3
Jun Young Ha, Mi Sun Sung, Sang Woo Park
PURPOSE: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular glaucoma. METHODS: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP)...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29018756/descemet-s-stripping-automated-endothelial-keratoplasty-for-symptomatic-thioridazine-deposits-in-the-cornea
#4
Masoumeh Mohebbi, Hassan Hashemi, Alireza Mahmoudi, Pasha Anvari
The aim of this study was to use Descemet's Stripping-automated Endothelial Keratoplasty (DSAEK) as a novel treatment to remove thioridazine corneal deposits. A 53-year-old female presented with a 3-month history of visual loss and glare. She had been taking thioridazine (100 mg/day for 1 year) for a psychiatric disorder. Dense yellowish-brown deposits had developed in the posterior stroma. Thioridazine was discontinued, and she was switched to fluoxetine. One year after discontinuation of thioridazine, her symptoms and signs did not resolve...
January 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/28994816/the-aortic-ring-co-culture-assay-a-convenient-tool-to-assess-the-angiogenic-potential-of-mesenchymal-stromal-cells-in-vitro
#5
Farwah Iqbal, Yarden S Gratch, Peter Szaraz, Clifford L Librach
Angiogenesis is a complex, highly regulated process responsible for providing and maintaining adequate tissue perfusion. Insufficient vasculature maintenance and pathological malformations can result in severe ischemic diseases, while overly abundant vascular development is associated with cancer and inflammatory disorders. A promising form of pro-angiogenic therapy is the use of angiogenic cell sources, which can provide regulatory factors as well as physical support for newly developing vasculature. Mesenchymal Stromal Cells (MSCs) are extensively investigated candidates for vascular regeneration due to their paracrine effects and their ability to detect and home to ischemic or inflamed tissues...
September 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28993974/unique-variations-and-characteristics-of-iridocorneal-endothelial-syndrome-in-china-a-case-series-of-58-patients
#6
Bo Feng, Xin Tang, Hong Chen, Xia Sun, Ningli Wang
PURPOSE: Iridocorneal endothelial (ICE) syndrome is a rare condition, and unique characteristics in Chinese patients can make diagnosis difficult. Our purpose was to describe the clinical characteristics and variations of ICE syndrome in 58 consecutive Chinese patients. METHODS: The clinical data of consecutive patients with ICE syndrome who were seen between 2008 and 2011 at the glaucoma clinic of our ophthalmology department were retrospectively reviewed. The diagnostic criteria for ICE syndrome were a "hammered-silver" appearance of the corneal endothelium and specular microscopy showing ICE cells characterized by the absence of a hexagonal appearance, dark areas within the cells, and a light-dark reversal pattern...
October 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28992107/flow-in-the-anterior-chamber-of-the-eye-with-an-implanted-iris-fixated-artificial-lens
#7
Jennifer H Tweedy, Jan O Pralits, Rodolfo Repetto, Paolo Soleri
Flow in the aqueous humour that fills the anterior chamber of the eye occurs in response to the production and drainage of the aqueous humour, and also due to buoyancy effects produced by thermal gradients. Phakic intraocular lenses are manufactured lenses that are surgically inserted in the eyes of patients to correct refractive errors. Their presence has a dramatic effect on the circulation of the aqueous humour, resulting a very different flow in the anterior chamber, the effects of which have not been extensively investigated...
August 7, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28991612/long-term-safety-follow-up-of-an-anterior-chamber-angle-supported-phakic-intraocular-lens
#8
Thomas Kohnen, Laura LaFontaine, Russell Andrew
PURPOSE: To report adverse device effects and annualized endothelial cell loss rate for up to 10 years after implantation of the Acrysof L-series Cachet phakic intraocular lens (pIOL). SETTING: Clinical centers in the United States, European Union, and Canada. DESIGN: Nonrandomized clinical trial. METHODS: After implantation of the pIOL, the endothelial cell density (ECD) at follow-up evaluations was compared with the 6-month postoperative baseline...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28991340/comparison-of-corneal-endothelial-cell-loss-between-two-femtosecond-laser-platforms-and-standard-phacoemulsification
#9
Zaina Al-Mohtaseb, Xu He, Nilufer Yesilirmak, Daniel Waren, Kendall E Donaldson
PURPOSE: To analyze and compare the changes in endothelial cell density (ECD) and cumulative dissipated energy (CDE) in patients having cataract surgery with two different femtosecond laser platforms and standard phacoemulsification. METHODS: This prospective non-randomized comparative study included patients scheduled to undergo cataract extraction using femtosecond laser-assisted cataract surgery (FLACS) (60 eyes) or standard phacoemulsification (60 eyes) between September 2013 and March 2016...
October 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28990995/donor-tissue-preparation-for-descemet-membrane-endothelial-keratoplasty-an-updated-review
#10
Rénuka S Birbal, Shameema Sikder, Jessica T Lie, Esther A Groeneveld-van Beek, Silke Oellerich, Gerrit R J Melles
PURPOSE: To provide an overview of the current literature on donor tissue preparation for Descemet membrane endothelial keratoplasty (DMEK). METHODS: A comprehensive database search without date restrictions was performed in PubMed and in The Cochrane Library in May, 2017. Keywords included Descemet membrane endothelial keratoplasty, corneal transplantation, graft, harvest, dissection, preparation, endothelial cell, and endothelial cell density. Articles aiming to describe or evaluate a technique for DMEK graft preparation were considered eligible and were included in this review...
October 5, 2017: Cornea
https://www.readbyqxmd.com/read/28990988/case-report-in-vivo-confocal-microscopic-appearance-of-corneal-argyrosis
#11
Mengliang Wu, Xiaochun Wang, Tingting Shao, Yan Wang
SIGNIFICANCE: This report details the natural history of corneal argyrosis over 3 years using in vivo confocal microscopy to document regression of hyperreflective deposits, as well as effects on corneal nerves and endothelial cell morphology. PURPOSE: To report the in vivo confocal microscopic features and clinical characteristics of a case of bilateral corneal argyrosis. CASE REPORT: A 52-year-old man referred to us 3 months following cautery of the palpebral conjunctiva of both eyes with a silver nitrate stick was observed over the course of 3 years, during which slit-lamp photography and in vivo confocal microscopy were performed...
October 5, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28988897/outcomes-and-prognostic-factors-of-cataract-surgery-in-adult-extreme-microphthalmos-with-axial-length-18-mm-or-corneal-diameter-8-mm
#12
Tianyu Zheng, Zhanghua Chen, Jie Xu, Yating Tang, Qi Fan, Yi Lu
PURPOSE: To study the long-term visual outcomes, complications and prognostic factors for cataract surgery in extreme microphthalmos. DESIGN: Prospective cohort study. METHODS: Thirty eyes with simple microphthalmos [11 eyes, axial length (AL) <18 mm], complex microphthalmos [8 eyes, AL <18 mm] and relative anterior microphthalmos [RAM, 11 eyes, corneal diameter (CD) <8 mm] who underwent cataract surgery (phacoemulsification) in our hospital were followed for a mean of 25...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28987448/fungal-keratitis
#13
REVIEW
T Bourcier, A Sauer, A Dory, J Denis, M Sabou
Fungal keratitis, or keratomycoses, are corneal infections which must be considered in cases of corneal trauma, prior corneal surgery, chronic ocular surface disease, topical corticosteroids or contact lens wear. Filamentous fungi or yeasts may be involved. Presenting clinical features such as corneal infiltrates with feathery edges and/or raised surface, intact epithelium with deep stromal involvement, satellite lesions, endothelial plaques, lack of improvement with antibiotics and worsening with steroids are suggestive of fungal keratitis...
October 4, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28986008/characterisation-of-the-porcine-eyeball-as-an-in-vitro-model-for-dry-eye
#14
Francesco Menduni, Leon N Davies, D Madrid-Costa, Antonio Fratini, James S Wolffsohn
PURPOSE: To characterise the anatomical parameters of the porcine eye for potentially using it as a laboratory model of dry eye. METHODS: Anterior chamber depth and angle, corneal curvature, shortest and longest diameter, endothelial cell density, and pachymetry were measured in sixty freshly enucleated porcine eyeballs. RESULTS: Corneal steepest meridian was 7.85±0.32mm, corneal flattest meridian was 8.28±0.32mm, shortest corneal diameter was 12...
October 3, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28985815/young-donor-graft-assisted-endothelial-keratoplasty-pdek-dmek-with-epithelial-debridement-for-chronic-pseudophakic-bullous-keratopathy
#15
Amar Agarwal, Priya Narang, Dhivya A Kumar, Ashvin Agarwal
OBJECTIVE: The aim of this study was to describe the applicability and report visual outcomes for the treatment of subepithelial fibrosis and anterior stromal scarring in cases of chronic pseudophakic bullous keratopathy (PBK) with epithelial debridement and endothelial keratoplasty (EK) (pre-Descemet endothelial keratoplasty [PDEK]; Descemet membrane endothelial keratoplasty [(DMEK]) using young donor tissue. DESIGN: Prospective, single-centre, interventional study...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28985226/scaling-and-maintenance-of-corneal-thickness-during-aging
#16
Takenori Inomata, Alireza Mashaghi, Jiaxu Hong, Takeshi Nakao, Reza Dana
Corneal thickness is tightly regulated by its boundary endothelial and epithelial layers. The regulated set-point of corneal thickness likely shows inter-individual variations, changes by age, and response to stress. Using anterior segment-optical coherence tomography, we measure murine central corneal thickness and report on body size scaling of murine central corneal thickness during aging. For aged-matched mice, we find that corneal thickness depends on sex and strain. To shed mechanistic insights into these anatomical changes, we measure epithelial layer integrity and endothelial cell density during the life span of the mice using corneal fluorescein staining and in vivo confocal microscopy, respectively and compare their trends with that of the corneal thickness...
2017: PloS One
https://www.readbyqxmd.com/read/28984766/flattening-effect-of-corneal-cross-linking-depends-on-the-preoperative-severity-of-keratoconus
#17
Kozue Kasai, Naoko Kato, Kenji Konomi, Megumi Shinzawa, Jun Shimazaki
A retrospective observational study was conducted to validate the effect of corneal cross-linking (CXL) on eyes with progressing keratoconus, depending on severity.In total, 45 eyes of 33 patients (age: 23.9 ± 6.8 years, range: 14-42 years) with progressive keratoconus who underwent CXL were enrolled. Examinations were performed at pre-, 1, 3, 6, and 12 months after surgery. In addition to a slit lamp microscopy, measurement of visual acuity, the steepest keratometric value (Kmax), the thinnest corneal thickness (TCT), and the corneal endothelial cell density (ECD) were assessed...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984756/preoperative-photocoagulation-reduces-corneal-endothelial-cell-damage-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#18
Jie Zhong, Jun Jia, Jiguo Yu, Liping Zhang, Yi Xiang
Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemorrhage, who underwent vitrectomy. Patients were apportioned to a photocoagulation group (26 eyes/23 patients) or nonphotocoagulation group (26/23 patients), according to their history of preoperative photocoagulation...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28982949/the-existence-of-dead-cells-in-donor-corneal-endothelium-preserved-with-storage-media
#19
Koji Kitazawa, Tsutomu Inatomi, Hidetoshi Tanioka, Satoshi Kawasaki, Hiroko Nakagawa, Osamu Hieda, Hideki Fukuoka, Naoki Okumura, Noriko Koizumi, Bernie Iliakis, Chie Sotozono, Shigeru Kinoshita
AIM: To investigate the viability of donor corneal endothelial cells (CECs) preserved in storage media by histological examination. METHODS: Twenty-eight donor corneas were obtained from SightLife Eye Bank (Seattle, Washington), and redundant peripheral portions of those corneas were used for histological examination after removal of the centre corneal graft for transplantation. To assess cell viability in the corneal endothelium, biostaining experiments were performed using propidium iodide, calcein-AM, Hoechst 33 342, annexin V, anti-vimentin antibody and toluidine blue...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28979685/the-injection-of-discovisc-into-the-anterior-chamber-improved-corneal-preservation-and-transplantation-for-cornea-blind-patients
#20
Bing Li, Li Chen, Yihui Chen, Jiajun Lu, Hao Liu, Yu Liu, Panpan Yao, Rui Liu, Minjie Sheng
PURPOSE: In this study, we aimed to provide a new method of corneal preservation by injecting DisCoVisc into the anterior chamber of eyeballs and evaluate its efficiency for corneal transplantation. METHODS: Three pairs of eyeballs (n=6) were preserved by DisCoVisc viscoelastic agent, and the corneas were stored for 1 to 6 days. Then, the structure and morphology of cornea were analyzed by hematoxylin-eosin (H&E) staining, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, and transmission electron microscopy (TEM)...
2017: American Journal of Translational Research
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