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Corneal endotheliitis

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https://www.readbyqxmd.com/read/29227512/efficacy-and-safety-comparison-between-suberoylanilide-hydroxamic-acid-and-mitomycin-c-in-reducing-the-risk-of-corneal-haze-after-prk-treatment-in-vivo
#1
Govindaraj Anumanthan, Ajay Sharma, Michael Waggoner, Chuck W Hamm, Suneel Gupta, Nathan P Hesemann, Rajiv R Mohan
PURPOSE: This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo. METHODS: Corneal haze in rabbits was produced with -9.00 diopter PRK. A single application of SAHA (25 μM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29227341/characterization-of-corneal-endothelial-injury-during-penetrating-keratoplasty
#2
Thomas A Vo, Zack Oakey, Sumit Garg
PURPOSE: To characterize corneal endothelial injury during penetrating keratoplasty in a controlled wet laboratory environment using human tissue. To identify potential areas or steps within surgery in which insult to the corneal endothelium may be most affected by trauma during routine penetrating keratoplasty. METHODS: Human donor corneas (n = 12) with intact endothelium underwent experimental penetrating keratoplasty. Endothelial injury was evaluated after each suture quartile using trypan staining, a validated modality for assessing endothelial injury...
December 8, 2017: Cornea
https://www.readbyqxmd.com/read/29227340/corneal-transplantation-in-new-zealand-2000-to-2009
#3
Alexandra Z Crawford, Thiyagaraj Krishnan, Susan E Ormonde, Dipika V Patel, Charles N McGhee
PURPOSE: To quantify all minor/major adverse events in a large cohort of consecutive corneal transplants, particularly in respect to penetrating keratoplasty (PKP). METHODS: All corneal transplants in the Auckland region over a 10-year period (2000-2009) were identified through the New Zealand National Eye Bank. Relevant clinical records were assessed for this period and 2 years after. All intraoperative or postoperative adverse events/complications, visual acuity, and graft outcomes were recorded...
December 8, 2017: Cornea
https://www.readbyqxmd.com/read/29225985/late-onset-descemet-membrane-detachment-after-radial-keratotomy-resolved-with-medical-therapy
#4
P Rosetta, E F Legrottaglie, R Vinciguerra, P Vinciguerra
Purpose: To report a case of a Descemet membrane's (DM) detachment after radial keratotomy (RK). Methods: A patient (male) underwent RK (16 cuts) 20 years before referring to the Eye Center of Humanitas (Milan) for a progressive visual loss. The slit-lamp examination showed severe corneal stromal edema and a large DM detachment in the lower half of the cornea. Anterior segment optical coherence tomography (AS-OCT) and endothelial cells count confirmed DM detachment and endothelial cells damage...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29223239/phacoemulsification-with-intraocular-lens-implantation-after-previous-descemetorhexis-without-endothelial-keratoplasty
#5
Aaron R Kaufman, Ricardo M Nosé, Yifan Lu, Roberto Pineda
A 58-year-old woman with bilateral Fuchs endothelial corneal dystrophy presented with predominantly central guttata in the left eye causing visually significant stromal edema. A 4.0 mm descemetorhexis without endothelial keratoplasty was performed. At the 6-week follow-up, the central cornea had cleared completely and the central endothelial cell density (ECD) was 541 cells/mm2. The central corneal clearing remained stable for 2 years after the procedure; however, vision declined because of a visually significant cataract in the left eye...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29218423/early-intraocular-pressure-change-after-peripheral-iridotomy-with-ultralow-fluence-pattern-scanning-laser-and-nd-yag-laser-in-primary-angle-closure-suspect-kowloon-east%C3%A2-pattern-scanning-laser-study-report-no-3
#6
Jeffrey Chi Wang Chan, Bonnie Nga Kwan Choy, Orlando Chia Chieh Chan, Kenneth Kai Wang Li
PURPOSE: Our purpose was to assess the early intraocular pressure (IOP) changes of ultralow fluence laser iridotomy using pattern scanning laser followed by neodymium:yttrium-aluminum-gamet (Nd:YAG) laser. METHODS: This is a prospective interventional study. Thirty-three eyes of 33 adult Chinese primary angle-closure suspect subjects were recruited for prophylactic laser peripheral iridotomy. Sequential laser peripheral iridotomy was performed using pattern scanning laser followed by Nd:YAG laser...
December 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29218212/heads-up-descemet-membrane-endothelial-keratoplasty-performed-using-a-3d-visualization-system
#7
Virgilio Galvis, Ruben D Berrospi, Juan D Arias, Alejandro Tello, Julio C Bernal
A 68-year-old female underwent Descemet membrane endothelial keratoplasty (DMEK) in her right eye using a 3D visualization system with the surgeon looking directly to a digital screen instead of through the eyepieces of the surgical microscope. The procedure was uneventful. Five weeks after the surgery the DMEK graft was in good position and totally adhered, the cornea clear and uncorrected distance visual acuity 20/50. This is the first reported case of DMEK using 3D augmented reality visualization system...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29213190/smartphone-based-imaging-of-the-corneal-endothelium-at-sub-cellular-resolution
#8
Devrim Toslak, Damber Thapa, Muhammet Kazim Erol, Yanjun Chen, Xincheng Yao
This aim of this study was to test the feasibility of smartphone-based specular microscopy of the corneal endothelium at a sub-cellular resolution. Quantitative examination of endothelial cells is essential for evaluating corneal disease such as determining a diagnosis, monitoring progression and assessing treatment. Smartphone-based technology promises a new opportunity to develop affordable devices to foster quantitative examination of endothelial cells in rural and underserved areas. In our study, we incorporated an iPhone 6 and a slit lamp to demonstrate the feasibility of smartphone-based microscopy of the corneal endothelium at a sub-cellular resolution...
2017: Journal of Modern Optics
https://www.readbyqxmd.com/read/29209447/nrf2-a-potential-therapeutic-target-against-oxidative-stress-in-corneal-diseases
#9
REVIEW
Xiu-Fen Liu, Dan-Dan Zhou, Tian Xie, Tayyab Hamid Malik, Cheng-Bo Lu, Hai-Jun Li, Fan Wang, Chang Shu, Cong Liu, Cheng-Wei Lu, Ji-Long Hao
Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like erythroid-cell-derived protein with CNC homology- (ECH-) associated protein 1 (Keap1)/antioxidant response element (ARE) signaling is well known as one of the main antioxidative defense systems...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29208833/sutureless-27-gauge-needle-assisted-transconjunctival-intrascleral-intraocular-lens-fixation-initial-experience
#10
Aditya Shrikant Kelkar, Rajesh Fogla, Jai Kelkar, Akshay Anil Kothari, Hetal Mehta, Winfried Amoaku
PURPOSE: The purpose of the study was to report our initial experience with the transconjunctival Intrascleral Intraocular Lens (SFIOL) fixation with modified Yamane's double-needle technique and flanged haptics. METHODS: This was a prospective interventional study that enrolled 31 consecutive patients undergoing SFIOL with the modified Yamane's technique. All patients underwent comprehensive evaluation including uncorrected and best-corrected vision, intraocular pressure, ultrasound biomicroscopy, endothelial cell density, and macular thickness using optical coherence tomography (OCT)...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208829/comparative-analysis-of-endothelial-cell-loss-following-phacoemulsification-in-pupils-of-different-sizes
#11
Rakesh Maggon, Raghudev Bhattacharjee, Sandeep Shankar, Rajesh Chandra Kar, Vivek Sharma, Shyamal Roy
PURPOSE: To compare Endothelial cell(EC) loss following Phacoemulsification (PKE) in pupils of different sizes. METHODS: A prospective double masked observational study in which a total of 150 eyes of 150 patients between 50 & 70 years of age with senile cataract of nuclear sclerosis grade II were enrolled. Patients were allocated into three groups of 50 eyes each in Group A (pupil size <5 mm), Group B (pupil size 5-7 mm) and Group C (pupil size >7 mm). Pupillary size was measured by determining the height of slit on slit-lamp biomicroscope examination...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208828/a-simple-technique-of-intraocular-lenses-explantation-for-single-piece-foldable-lenses
#12
Arup Bhaumik, Santanu Mitra
Foldable intraocular lenses (IOLs) are most commonly used in modern-day cataract surgery. Explantation of these IOLs is not frequently encountered, but sometimes extreme situations may demand the same. Commonly explantation is achieved by bisecting the IOL inside the anterior chamber with a cutter and delivering the pieces out one by one. This may require corneal wound extension with associated damage and endothelial loss leading to visual deterioration. We devised a simple, innovative IOL explantation technique utilizing a modified Alcon A cartridge and snare...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29208818/corneal-edema-after-phacoemulsification
#13
REVIEW
Namrata Sharma, Deepali Singhal, Sreelakshmi P Nair, Pranita Sahay, S S Sreeshankar, Prafulla Kumar Maharana
Phacoemulsification is the most commonly performed cataract surgery in this era. With all the recent advances in investigations and management of cataract through phacoemulsification, most of the patients are able to achieve excellent visual outcome. Corneal edema after phacoemulsification in the immediate postoperative period often leads to patient dissatisfaction and worsening of outcome. Delayed onset corneal edema often warrants endothelial keratoplasty. This review highlights the etiopathogenesis, risk factors, and management of corneal edema in the acute phase including descemet's membrane detachment (DMD) and toxic anterior segment syndrome...
December 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29207076/antiangiogenic-effects-of-catalpol-on-rat-corneal%C3%A2-neovascularization
#14
Yun Han, Mei Shen, Li-Yuan Tang, Gang Tan, Qi-Chen Yang, Lei Ye, Lin-Hong Ye, Nan Jiang, Gui-Ping Gao, Yi Shao
To investigate the effects of catalpol on corneal neovascularization (CNV) and associated inflammation, eye drops (5 mM catalpol or PBS) were administered four times daily to alkali‑burn rat models of CNV and inflammation. Clinical evaluations of CNV and the degree of inflammation were performed on days 0, 4, 7, 10 and 14 under slit lamp microscopy. Eyes were collected on day 14 and prepared for hematoxylin and eosin, and immunofluorescence staining; corneal cell apoptosis was investigated via terminal deoxynucleotidyl transferase‑mediated nick end labeling (TUNEL) staining...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29206654/descemet-membrane-endothelial-keratoplasty-and-glaucoma
#15
Marcus Ang, Chelvin C A Sng
PURPOSE OF REVIEW: The aim of this review is to describe the relationship between Descemet membrane endothelial keratoplasty (DMEK) and glaucoma. RECENT FINDINGS: Glaucoma after DMEK is a serious complication that may cause permanent visual loss, affect donor endothelial cells and graft survival. The mechanisms of raised intraocular pressure (IOP) after DMEK include reverse pupillary block in the early postoperative period, and steroid response in the late phase...
December 4, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29205032/apratyramide-a-marine-derived-peptidic-stimulator-of-vegf-a-and-other-growth-factors-with-potential-application-in-wound-healing
#16
Weijing Cai, Lilibeth A Salvador-Reyes, Wei Zhang, Qi-Yin Chen, Susan Matthew, Ranjala Ratnayake, Soo Jung Seo, Simon Dolles, Daniel J Gibson, Valerie J Paul, Hendrik Luesch
A novel linear depsipeptide enriched with tyrosine-derived moieties, termed apratyramide, was isolated from an apratoxin-producing cyanobacterium. The structure was determined using a combination of NMR spectroscopy, mass spectrometry, and chiral analysis of the acid hydrolyzate and confirmed by total synthesis. Apratyramide up-regulated multiple growth factors at the transcript level in human keratinocyte (HaCaT) cells and induced the secretion of vascular endothelial growth factor A (VEGF-A) from HaCaT cells, suggesting the compound's potential wound-healing properties through growth factor induction...
December 5, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29194202/evaluation-of-angle-closure-as-a-risk-factor-for-reduced-corneal-endothelial-cell-density
#17
(no author information available yet)
No abstract text is available yet for this article.
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29194200/evaluation-of-angle-closure-as-a-risk-factor-for-reduced-corneal-endothelial-cell-density-comment
#18
Amit Kumar Purang, Neha Sharma, Julie Pegu, Suneeta Dubey
No abstract text is available yet for this article.
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29193851/survival-of-corneal-nerve-sheath-structures-in-organ-cultured-donor-corneas
#19
Virinder K Dhillon, Mohamed S Elalfy, Marco Messina, Mouhamed Al-Aqaba, Harminder S Dua
PURPOSE: To study the morphology of human corneal nerves in eye bank organ-cultured corneas and in corneal grafts post-transplantation. METHODS: Thirty-seven organ-cultured corneas were divided into: Group-A, anterior 300-400 μm of 20 corneas used for Descemets stripping endothelial keratoplasty, and Group-B, 17 full-thickness corneas unsuitable for transplantation. Corneas whole mounts were stained for nerves using acetylcholinesterase technique and examined by NanoZoomer digital pathology microscope...
November 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29190797/topographic-characteristics-after-descemet-s-membrane-endothelial-keratoplasty-and-descemet-s-stripping-automated-endothelial-keratoplasty
#20
Takahiko Hayashi, Takefumi Yamaguchi, Kentaro Yuda, Naoko Kato, Yoshiyuki Satake, Jun Shimazaki
PURPOSE: To investigate the topographic characteristics of the posterior corneal surface after Descemet's endothelial membrane keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK) and their effects on postoperative visual acuity. METHODS: Nineteen eyes of 19 patients after DMEK, 23 eyes of 23 patients after DSAEK, and 18 eyes of 18 control subjects were retrospectively analyzed. Best spectacle-corrected visual acuity (BSCVA), aberration factors (higher-order aberrations [HOAs], spherical aberrations [SAs], and coma aberrations [Comas] at 6...
2017: PloS One
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