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Disciform keratitis

Wenjia Xie, Yesheng Xu, Yu-Feng Yao
PURPOSE: To describe a case of Descemet's membrane detachment and schisis (Descemet's membrane separated into multiple layers) with confirmation by high-definition anterior segment optical coherence tomography (AS-OCT) after phacoemulsification and intraocular lens implantation. CASE REPORT: A 72-year-old woman presented with persistent corneal edema after phacoemulsification. She was diagnosed with herpes simplex keratitis and had been unsuccessfully treated for 60 days in her local hospital...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Jun Shoji, Tohru Sakimoto, Noriko Inada, Yuko Kamei, Masao Matsubara, Etsuko Takamura, Mitsuru Sawa
PURPOSE: We performed simultaneous measurement of herpes simplex virus (HSV) DNA by real-time polymerase chain reaction (real-time PCR) and of HSV-specific secretory IgA antibody (HSV-sIgA) by enzyme-linked immunosorbent assay (ELISA) in tears obtained using Schirmer strips in order to investigate its diagnostic efficacy for herpes simplex keratitis (HSK). METHODS: A total of 59 affected eyes from 59 patients with clinically suspected HSK (HSK group) and 23 eyes from 23 healthy volunteers (control group) were enrolled in this study...
July 2016: Japanese Journal of Ophthalmology
Nisha Chadha, David A Belyea, Sanjeev Grewal
This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etiology has been unclear. Our cases highlight HSV as a likely etiology, which may help with prevention and better management of such cases in the future...
2016: Case Reports in Ophthalmological Medicine
B Seitz, A Heiligenhaus
In Europe, herpes simplex virus type I (HSV) is a common cause of keratitis. The disease may be well treated if the ophthalmologtist is aware of the various types of clinical expressions of this typical unilateral chameleon, and treatment is adjusted accordingly. Types of expression include: (i) epithelial keratitis (dendritica/geographica), (ii) stromal keratitis (necrotising vs. non-necrotising = "interstitial keratitis"), (iii) endotheliitis (= "disciform keratitis"), (iv) so-called "metaherpetic keratitis" (= neurotrophic keratopathy), (v) (vascularised) corneal scars...
June 2015: Klinische Monatsblätter Für Augenheilkunde
E Akhmedova, S Goebels, U Löw, F Bauer, N Szentmáry, B Seitz
No abstract text is available yet for this article.
June 2015: Klinische Monatsblätter Für Augenheilkunde
M Fiorentzis, N Szentmáry, B Seitz
BACKGROUND: Bilateral keratitis is rare and can have various causes. For a good outcome after treatment, the correct diagnosis is decisive. CASE REPORT: A 15-year-old boy presented to our clinic with recurrent keratoconjunctivitis and progressive loss of vision in both eyes since 6 years. The best corrected visual acuity was 0.1 in the right eye and 1/12 in the left eye. Slit-lamp examination verified keratitis disciformis with strongly vascularized corneal stromal scars without conjunctival follicles on both sides...
February 2015: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Aditya Kapoor, Rajat Jain, Srikant Sahu, Virender Sangwan
A 44-year-old man presented with severe pain, redness, watering and photophobia for 10 days in the right eye without any history of trauma. Diagnosis of herpes simplex disciform keratitis was made and he was prescribed topical steroids. The patient showed clinical worsening and presented with ring infiltrate, diffuse stromal oedema and radial keratoneuritis, a finding pathognomic of acanthamoeba keratitis. With two inconclusive corneal scrapings and the patient showing clinical worsening, an urgent therapeutic penetrating keratoplasty was carried out...
2014: BMJ Case Reports
Angeline Hixson, Smith Blanc, Joseph Sowka
PURPOSE: Biomicroscopy is generally used, sometimes in conjunction with photography or ultrasound pachymetry, to monitor conditions involving stromal keratitis and edema. Spectral-domain optical coherence tomography (SD-OCT), a technology typically used to examine the posterior segment, may be useful in monitoring the therapeutic interventions for conditions involving corneal edema such as disciform keratitis. CASE REPORTS: Two cases of disciform keratitis were followed to resolution using SD-OCT with anterior segment imaging software (Cirrus 4000; Carl Zeiss Meditec, Dublin, CA) to quantify decreasing edema throughout treatment...
April 2014: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Yuzhao Sun, Jing Hong, Pei Zhang, Rongmei Peng, Gege Xiao
AIMS: To classify the clinical stages of Acanthamoeba keratitis (AK), and clarify the relationship between pathological changes and clinical features. METHODS AND RESULTS: Between January 2007 and May 2012, AK was diagnosed in 11 eyes by pathological examination and confocal laser scanning microscopy. Pathological investigation of all cornea samples from keratoplasty was done with periodic acid-Schiff and haematoxylin and eosin stains. AK clinical stage, pathological features and postoperative treatment were studied retrospectively...
December 2013: Histopathology
Ngamjit Kasetsuwan, Chulaluck Tangmonkongvoragul
A case of an immunocompetent 51-year-old healthy man with chronic recurrent disciform corneal oedema and hypertensive anterior uveitis in the right eye for 2 years was unresponsive to topical corticosteroid and systemic acyclovir. Diagnostic anterior chamber tapping was performed and viral DNA PCR was positive for both cytomegalovirus and herpes simplex virus. The patient was treated with both oral valganciclovir for 3 months and long-term oral acyclovir. His condition improved significantly after the treatment; intraocular pressure and anterior chamber inflammation were controlled and the remaining keratic precipitates in the cornea started to clear up...
2013: BMJ Case Reports
Palanisamy S Suresh
Reiter's syndrome is commonly associated with conjunctivitis and rarely with uveitis. Bilateral disciform keratitis at presentation is a very rare manifestation in Reiter's syndrome. A 13-year-old boy developed bilateral disciform keratitis with oligoarthritis following an episode of conjunctivitis. In addition he had suspected bacterial keratitis with hypopyon in the left eye as a possible secondary infection of an epithelial defect that is a feature of Reiter's keratitis. Empirical treatment with intensive topical antibiotics as a therapeutic trial completely resolved the hypopyon and the disciform keratitis settled with topical steroid treatment...
April 3, 2013: Indian Journal of Ophthalmology
Mae-Lynn Catherine Bastion, Aida Zairani Mohd Zahidin
An unusual case of disciform keratitis developing in a patient with silicone oil-filled eye following vitrectomies for posterior globe rupture.
2010: BMJ Case Reports
Shi-jing Deng, Wei-wei Li, Wen-bo Hou, Xu-guang Sun
OBJECTIVE: To study the cellular morphological characteristics and changes of corneal endotheliitis by corneal microstructure in vivo. METHODS: Forty-eight clinical diagnosed patients of corneal endotheliitis were examined by in vivo confocal microscopy. Confocal images of different layers were collected and observed. Of all the patients, 39 were disciform and 9 were diffuse. The history of the 48 patients was from 7 days to 23 years and the duration was from 4 to 180 days...
January 2012: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
B Seitz, A Heiligenhaus
Herpes simplex virus (HSV) is a common cause of keratitis. "Herpetic keratitis" is a chameleon, which is well treatable today if the various types of clinical expression of this disease are known to the ophthalmologist and treatment is adjusted accordingly. Types of expression include 1. epithelial keratitis (dendritica/geographica), 2. stromal keratitis (necrotizing vs. non-necrotizing = "interstitial keratitis"), 3. endotheliitis (=disciform keratitis), 4. neurotrophic keratopathy (=so-called metaherpetic keratitis) and 5...
April 2011: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Srinivasan Sanjay, Philemon Huang, Raghavan Lavanya
The management of herpes zoster (HZ) usually involves a multidisciplinary approach aiming to reduce complications and morbidity. Patients with herpes zoster ophthalmicus (HZO) are referred to ophthalmologists for prevention or treatment of its potential complications. Without prompt detection and treatment, HZO can lead to substantial visual disability. In our practice, we usually evaluate patients with HZO for corneal complications such as epithelial, stromal, and disciform keratitis; anterior uveitis; necrotizing retinitis; and cranial nerve palsies in relation to the eye...
February 2011: Current Treatment Options in Neurology
Alireza Khodabande
PURPOSE: To report a case of varicella endotheliitis. METHODS: An 18-year-old patient with varicella presented with photophobia and reduced vision in his left eye because of disciform corneal endotheliitis. RESULTS: Ocular symptoms and signs resolved completely except for small sectoral iris atrophy with combined antiviral and corticosteroid therapy. CONCLUSIONS: We report a rare presentation of varicella.
November 2009: European Journal of Ophthalmology
Eun Chul Kim, Man Soo Kim
PURPOSE: To report bilateral Acanthamoeba keratitis after wearing an overnight reverse geometry contact lens for 5 days. METHODS: Case report and review of the medical literature. RESULTS: A 22-year-old woman developed bilateral corneal ulcers during orthokeratology. A slit-lamp examination revealed round epithelial abrasion, radial infiltration, and disciform keratitis in both corneas. Visual acuity in her right eye (OD) was hand motion and left eye (OS) was counting fingers...
June 2010: Cornea
Vandana Jain, Roberto Pineda
A 40-year-old woman presented with an unusual form of corneal herpetic reactivation 5 weeks after laser in situ keratomileusis. The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance). Oral antiviral and topical steroids in tapered dosages were administered. The infiltrate disappeared within 6 weeks. Progressive improvement was also seen in all the parameters on Pentacam scans, including the pachymetry, keratometry readings, and elevation on the anterior float. Herpetic reactivation may occur in many forms after excimer laser ablation...
May 2009: Journal of Cataract and Refractive Surgery
Eun Chul Kim, Man Soo Kim
PURPOSE: To report bilateral Acanthamoeba keratitis after wearing an overnight reverse geometric contact lens for 5 days. METHODS: Case report and review of the medical literature RESULTS: A 22-year-old woman developed bilateral corneal ulcers during orthokeratology. A slit-lamp examination showed round epithelial abrasion, radial infiltration, and disciform keratitis in both corneas. Visual acuity OD was hand motion and OS was counting fingers...
April 2009: Cornea
Kirk R Wilhelmus, Bradley M Mitchell, Chandler R Dawson, Dan B Jones, Bruce A Barron, Herbert E Kaufman, Joel Sugar, Robert A Hyndiuk, Peter R Laibson, R Doyle Stulting, Penny A Asbell
OBJECTIVE: To validate photographic bioimaging for evaluating the severity of herpes simplex virus keratitis. METHODS: Stromal keratitis of patients in the Herpetic Eye Disease Study was clinically measured with a slitbeam micrometer and then photographed at trial entry. Calibrated images of 169 eyes were analyzed for the size, location, and density of stromal keratitis and endotheliitis, with shape factor as a function of area and perimeter. Validity was assessed by comparing clinical and computerized measurements and by correlating the keratitis area with visual acuity...
February 2009: Archives of Ophthalmology
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