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uridine monophosphate

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https://www.readbyqxmd.com/read/27907199/identification-heterologous-expression-and-functional-characterization-of-bacillus-subtilis-yutf-a-had-superfamily-5-nucleotidase-with-broad-substrate-specificity
#1
Natalia P Zakataeva, Dmitriy V Romanenkov, Yuliya R Yusupova, Victoria S Skripnikova, Takayuki Asahara, Sergey V Gronskiy
5'-nucleotidases (EC 3.1.3.5) catalyze the hydrolytic dephosphorylation of 5'-ribonucleotides and 5'-deoxyribonucleotides as well as complex nucleotides, such as uridine 5'-diphosphoglucose (UDP-glucose), nicotinamide adenine dinucleotide and flavin adenine dinucleotide, to their corresponding nucleosides plus phosphate. These enzymes have been found in diverse species in intracellular and membrane-bound, surface-localized forms. Soluble forms of 5'-nucleotidases belong to the ubiquitous haloacid dehalogenase superfamily (HADSF) and have been shown to be involved in the regulation of nucleotide, nucleoside and nicotinamide adenine dinucleotide (NAD+) pools...
2016: PloS One
https://www.readbyqxmd.com/read/27896476/medicinal-chemistry-of-the-noncanonical-cyclic-nucleotides-ccmp-and-cump
#2
Frank Schwede, Andreas Rentsch, Hans-Gottfried Genieser
After decades of intensive research on adenosine-3',5'-cyclic monophosphate (cAMP)- and guanosine-3',5'-cyclic monophosphate (cGMP)-related second messenger systems, also the noncanonical congeners cyclic cytidine-3',5'-monophosphate (cCMP) and cyclic uridine-3',5'-monophosphate (cUMP) gained more and more interest. Until the late 1980s, only a small number of cCMP and cUMP analogs with sometimes undefined purities had been described. Moreover, most of these compounds had been rather synthesized as precursors of antitumor and antiviral nucleoside-5'-monophosphates and hence had not been tested for any second messenger activity...
November 29, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27847477/reverse-of-acute-and-chronic-morphine-tolerance-by-lithocholic-acid-via-down-regulating-ugt2b7
#3
Zizhao Yang, Li Li, Haihong Hu, Mingcheng Xu, Jingkai Gu, Zaijie Jim Wang, Lushan Yu, Su Zeng
Lithocholic acid (LCA) deposited in human livers always induces drastic pains which need analgesic drug, like morphine to release. Our research showed that LCA can effectively inhibit uridine 5'-diphospho-glucuronosyltransferase 2B7 (UGT2B7) in morphine tolerance-like human normal liver cells, HL-7702, then increase μ-opioid receptor (MOR) and calcium-calmodulin dependent protein kinase IIα (CaMKIIα) expression. In vivo assay, UGT2B7 was significantly repressed in the livers of acute or chronic morphine tolerance mice pretreated with LCA (10, 50, and 100 mg/kg, p...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27767993/effect-size-analyses-of-souvenaid-in-patients-with-alzheimer-s-disease
#4
Jeffrey Cummings, Philip Scheltens, Ian McKeith, Rafael Blesa, John E Harrison, Paulo H F Bertolucci, Kenneth Rockwood, David Wilkinson, Wouter Wijker, David A Bennett, Raj C Shah
BACKGROUND: Souvenaid® (uridine monophosphate, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium), was developed to support the formation and function of neuronal membranes. OBJECTIVE: To determine effect sizes observed in clinical trials of Souvenaid and to calculate the number needed to treat to show benefit or harm. METHODS: Data from all three reported randomized controlled trials of Souvenaid in Alzheimer's disease (AD) dementia (Souvenir I, Souvenir II, and S-Connect) and an open-label extension study were included in analyses of effect size for cognitive, functional, and behavioral outcomes...
October 20, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27754349/visual-and-plasmon-resonance-absorption-sensor-for-adenosine-triphosphate-based-on-the-high-affinity-between-phosphate-and-zr-iv
#5
Wenjing Qi, Zhongyuan Liu, Wei Zhang, Mohamed Ibrahim Halawa, Guobao Xu
Zr(IV) can form phosphate and Zr(IV) (-PO₃(2-)-Zr(4+)-) complex owing to the high affinity between Zr(IV) with phosphate. Zr(IV) can induce the aggregation of gold nanoparticles (AuNPs), while adenosine triphosphate(ATP) can prevent Zr(IV)-induced aggregation of AuNPs. Herein, a visual and plasmon resonance absorption (PRA)sensor for ATP have been developed using AuNPs based on the high affinity between Zr(IV)with ATP. AuNPs get aggregated in the presence of certain concentrations of Zr(IV). After the addition of ATP, ATP reacts with Zr(IV) and prevents AuNPs from aggregation, enabling the detection of ATP...
October 12, 2016: Sensors
https://www.readbyqxmd.com/read/27637357/folates-as-adjuvants-to-anticancer-agents-chemical-rationale-and-mechanism-of-action
#6
REVIEW
Peter V Danenberg, Bengt Gustavsson, Patrick Johnston, Per Lindberg, Rudolf Moser, Elisabeth Odin, Godefridus J Peters, Nicholas Petrelli
Folates have been used with cytotoxic agents for decades and today they are used in hundreds of thousands of patients annually. Folate metabolism is complex. In the treatment of cancer with 5-fluorouracil, the administration of folates mechanistically leads to the formation of [6R]-5,10-methylene-tetrahydrofolate, and the increased concentration of this molecule leads to stabilization of the ternary complex comprising thymidylate synthase, 2'-deoxy-uridine-5'-monophosphate, and [6R]-5,10-methylene-tetrahydrofolate...
October 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27635142/the-development-of-dna-based-methods-for-the-reliable-and-efficient-identification-of-nicotiana-tabacum-in-tobacco-and-its-derived-products
#7
Sukumar Biswas, Wei Fan, Rong Li, Sifan Li, Wenli Ping, Shujun Li, Alexandra Naumova, Tamara Peelen, Esther Kok, Zheng Yuan, Dabing Zhang, Jianxin Shi
Reliable methods are needed to detect the presence of tobacco components in tobacco products to effectively control smuggling and classify tariff and excise in tobacco industry to control illegal tobacco trade. In this study, two sensitive and specific DNA based methods, one quantitative real-time PCR (qPCR) assay and the other loop-mediated isothermal amplification (LAMP) assay, were developed for the reliable and efficient detection of the presence of tobacco (Nicotiana tabacum) in various tobacco samples and commodities...
2016: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/27628709/synthesis-of-unprecedented-sulfonylated-phosphono-exo-glycals-designed-as-inhibitors-of-the-three-mycobacterial-galactofuranose-processing-enzymes
#8
Christophe J-M Frédéric, Abdellatif Tikad, Jian Fu, Weidong Pan, Ruixiang B Zheng, Akihiko Koizumi, Xiaochao Xue, Todd L Lowary, Stéphane P Vincent
This study reports a new methodology to synthesize exo-glycals bearing both a sulfone and a phosphonate. This synthetic strategy provides a way to generate exo-glycals displaying two electron-withdrawing groups and was applied to eight different carbohydrates from the furanose and pyranose series. The Z/E configurations of these tetrasubstituted enol ethers could be ascertained using NMR spectroscopic techniques. Deprotection of an exo-glycal followed by an UMP (uridine monophosphate) coupling generated two new UDP (uridine diphosphate)-galactofuranose analogues...
September 15, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27574833/hereditary-orotic-aciduria-and-the-excretion-of-orotidine
#9
William L Nyhan, Jon A Gangoiti
Objective Orotic aciduria and deficiency of uridine monophosphate synthetase have been observed in a patient, studied over 10 years, who had no megaloblastic anemia. Excretion of orotic acid and orotidine were 8.24 and 0.52 mmol/mol of creatinine. The ratio of 15.85 differed appreciably from that of 6 patients reported with no megaloblastic anemia. Methods The analysis of orotidine by gas chromotography mass spectrometry was conducted. Conclusion Patients with orotic aciduria with and without megaloblastic anemia cannot be distinguished by ratio of orotic acid to orotidine...
December 2016: Neuropediatrics
https://www.readbyqxmd.com/read/27545761/organization-of-nucleotides-in-different-environments-and-the-formation-of-pre-polymers
#10
Sebastian Himbert, Mindy Chapman, David W Deamer, Maikel C Rheinstädter
RNA is a linear polymer of nucleotides linked by a ribose-phosphate backbone. Polymerization of nucleotides occurs in a condensation reaction in which phosphodiester bonds are formed. However, in the absence of enzymes and metabolism there has been no obvious way for RNA-like molecules to be produced and then encapsulated in cellular compartments. We investigated 5'-adenosine monophosphate (AMP) and 5'-uridine monophosphate (UMP) molecules confined in multi-lamellar phospholipid bilayers, nanoscopic films, ammonium chloride salt crystals and Montmorillonite clay, previously proposed to promote polymerization...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27259909/-ldv-sof-successful-in-general-practice-test
#11
Martin Bischoff
No abstract text is available yet for this article.
June 9, 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27099890/new-indications-for-harvoni
#12
(no author information available yet)
No abstract text is available yet for this article.
January 4, 2016: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/27090194/chemical-screening-identifies-eurd-as-a-novel-inhibitor-against-temozolomide-resistant-glioblastoma-initiating-cells
#13
Yoshihiro Tsukamoto, Naoki Ohtsu, Smile Echizenya, Satoko Otsuguro, Ryosuke Ogura, Manabu Natsumeda, Mizuho Isogawa, Hiroshi Aoki, Satoshi Ichikawa, Masahiro Sakaitani, Akira Matsuda, Katsumi Maenaka, Yukihiko Fujii, Toru Kondo
Glioblastoma (GBM), one of the most malignant human cancers, frequently recurs despite multimodal treatment with surgery and chemo/radiotherapies. GBM-initiating cells (GICs) are the likely cell-of-origin in recurrences, as they proliferate indefinitely, form tumors in vivo, and are resistant to chemo/radiotherapies. It is therefore crucial to find chemicals that specifically kill GICs. We established temozolomide (the standard medicine for GBM)-resistant GICs (GICRs) and used the cells for chemical screening...
August 2016: Stem Cells
https://www.readbyqxmd.com/read/26977297/lack-of-cross-resistance-to-ff-10501-an-inhibitor-of-inosine-5-monophosphate-dehydrogenase-in-azacitidine-resistant-cell-lines-selected-from-skm-1-and-molm-13-leukemia-cell-lines
#14
Motohiko Murase, Hiroyuki Iwamura, Kensuke Komatsu, Motoki Saito, Toshihiko Maekawa, Takaaki Nakamura, Takuya Yokokawa, Yasuhiro Shimada
Resistance to azacitidine is a major issue in the treatments of myelodysplastic syndrome and acute myeloid leukemia, and previous studies suggest that changes in drug metabolism are involved in the resistance. Therefore, drugs with mechanisms resistant or alternative to such metabolic changes have been desired for the treatment of resistant disease. We generated azacitidine-resistant cells derived from SKM-1 and MOLM-13 leukemia cell lines in vitro, analyzed the mechanisms, and examined the impact on the efficacy of other antimetabolic drugs...
February 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/26961599/the-urinary-metabolomic-profile-following-the-intake-of-meals-supplemented-with-a-cocoa-extract-in-middle-aged-obese-subjects
#15
Idoia Ibero-Baraibar, Ana Romo-Hualde, Carlos J Gonzalez-Navarro, M Angeles Zulet, J Alfredo Martinez
Metabolomics is used to assess the compliance and bioavailability of food components, as well as to evaluate the metabolic changes associated with food consumption. This study aimed to analyze the effect of consuming ready-to-eat meals containing a cocoa extract, within an energy restricted diet on urinary metabolomic changes. Fifty middle-aged volunteers [30.6 (2.3) kg m(-2)] participated in a 4-week randomised, parallel and double-blind study. Half consumed meals supplemented with 1.4 g of cocoa extract (645 mg polyphenols) while the remaining subjects received meals without cocoa supplementation...
April 2016: Food & Function
https://www.readbyqxmd.com/read/26801745/uridine-homeostatic-disorder-leads-to-dna-damage-and-tumorigenesis
#16
Zhe Cao, Jun Ma, Xinchun Chen, Boping Zhou, Chuan Cai, Dan Huang, Xuewen Zhang, Deliang Cao
Uridine is a natural nucleoside precursor of uridine monophosphate in organisms and thus is considered to be safe and is used in a wide range of clinical settings. The far-reaching effects of pharmacological uridine have long been neglected. Here, we report that the homeostatic disorder of uridine is carcinogenic. Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of uridine and increased spontaneous tumorigenesis by more than 3-fold. Multiple tumors (e.g., lymphoma, hepatoma and lung adenoma) occurred simultaneously in some UPase deficient mice, but not in wild-type mice raised under the same conditions...
March 28, 2016: Cancer Letters
https://www.readbyqxmd.com/read/26791135/rapid-determination-of-nucleotides-in-infant-formula-by-means-of-nano-liquid-chromatography
#17
María Mateos-Vivas, Salvatore Fanali, Encarnacíon Rodríguez-Gonzalo, Rita Carabias-Martínez, Zeineb Aturki
A rapid method for the quantification of five ribonucleotides 5'- monophophates (adenosine, cytidine, guanosine, inosine, uridine, 5'-monophosphate), in infant formula, has been proposed using nano-LC. To separate the studied compounds, capillary columns packed with different C18-based stationary phases were investigated. All the columns tested were laboratory prepared. The experiments were performed in ion-pairing RP chromatographic mode using tetrabutylammonium hydroxide as ion-pairing reagent. The method was developed using a core-shell XB-C18 capillary column with a mobile phase consisting of 5% v/v methanol and 95% v/v 100 mM ammonium formate, pH 8, containing 20 mM tetrabutylammonium hydroxide...
July 2016: Electrophoresis
https://www.readbyqxmd.com/read/26788571/ledipasvir-sofosbuvir-harvoni-a-therapeutic-advance-in-genotype-1-hepatitis-c-virus-infection-despite-uncertainties
#18
REVIEW
(no author information available yet)
Treatment for chronic hepatitis C depends on the hepatitis C virus (HCV) genotype and the patient's clinical characteristics. A fixed-dose combination of ledipasvir + sofosbuvir has been authorised in the European Union for adults with HCV genotype 1 (HCV-1), HCV-3 or HCV-4 infection. Ledipasvir targets the HCV protein NS5A, while sofosbuvir inhibits the HCV RNA polymerase NS5B. The ledipasvir+ sofosbuvircombination has not been compared directly with other antiviral drugs. No information is available on its ability to prevent hepatic complications, even in patients with cirrhosis...
December 2015: Prescrire International
https://www.readbyqxmd.com/read/26748441/structural-basis-of-substrate-specificity-in-porcine-rnase-4
#19
Shutian Liang, K Ravi Acharya
UNLABELLED: RNase 4, a member of the RNase A superfamily with substrate preference for uridine, has roles in host defence, angiogenesis and neurodegenerative diseases. It also exhibits the highest interspecies amino acid sequence similarity amongst RNase A family members. However, compared to other members of the RNase A family, including eosinophil-derived neurotoxin, eosinophil cationic protein and angiogenin, little is known about the molecular basis of substrate specificity in RNase 4...
March 2016: FEBS Journal
https://www.readbyqxmd.com/read/26730433/-hepatitis-c-genotype-1-harvoni-and-holkira-pak-reimbursed
#20
Guy Sabourin
No abstract text is available yet for this article.
November 2015: Perspective Infirmière: Revue Officielle de L'Ordre des Infirmières et Infirmiers du Québec
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