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https://www.readbyqxmd.com/read/29764822/numb-chin-syndrome-an-ominous-sign-of-mandibular-metastasis
#1
Abdul Razak, Bee See Goh, Jothi Raamahlingam Rajaran, Abd Jabar Nazimi
A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29761250/sarcoma-in-neurofibromatosis-2-case-report-and-review-of-the-literature
#2
C Linder, M J Smith, M Bulman, A Wallace, A J Freemont, D C Mangham, D G R Evans
Neurofibromatosis type 2 (NF2) is associated with the development of several types of benign nervous system tumours, while malignancies are rare. We report a 22-year-old man who presented with retroperitoneal and spinal high-grade sarcomas with epithelial features. Samples showed a mixed epithelioid and spindled cell content with little associated matrix and inconclusive immunochemistry. Genetic analysis of a schwannoma and matched blood samples demonstrated a constitutional de novo substitution at the splice donor site of intron 8 of the NF2 gene and aa acquired large deletion of the entire NF2 gene as a second hit, with some loss of SMARCB1...
May 14, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29745421/intradural-extramedullary-granular-cell-tumour-in-a-cat
#3
A Valentini, S Canal, M T Mandara, F Balducci, M Bernardini
A 7-year-old domestic shorthair cat was evaluated for progressive paraparesis, inability to jump, a paralysed tail and inability to void the bladder. Neurologic examination was consistent with a L4-S3 localisation. Survey radiographs of the lumbar vertebral column revealed L4-L7 vertebral body remodelling. A pre-contrast T1-weighted hyperintense, diffusely enhancing intradural lesion extending from L4 to S1 vertebral bodies was detected by MRI. Large, mesenchymal, round-to-polygonal cells arranged in nests or sheets were found on histologic examination at post mortem...
May 10, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29745256/salvage-of-cervical-motor-radiculopathy-using-peripheral-nerve-transfer-reconstruction
#4
Fardad T Afshari, Taushaba Hossain, Caroline Miller, Dominic M Power
PURPOSE: Motor nerve transfer surgery involves re-innervation of important distal muscles using either an expendable motor branch or a fascicle from an adjacent functioning nerve. This technique is established as part of the reconstructive algorithm for traumatic brachial plexus injuries. The reproducible outcomes of motor nerve transfer surgery have resulted in exploration of the application of this technique to other paralysing conditions. The objective of this study is to report feasibility and increase awareness about nerve transfer as a method of improving upper limb function in patients with cervical motor radiculopathy of different aetiology...
May 10, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29723241/intra-operative-cerebrospinal-fluid-sampling-versus-post-operative-lumbar-puncture-for-detection-of-leptomeningeal-disease-in-malignant-paediatric-brain-tumours
#5
Sharon Y Y Low, Chen Min Wei, Kenneth T E Chang, Chan Yiong Huak, Ng Lee Ping, Seow Wan Tew, David C Y Low
INTRODUCTION: Leptomeningeal disease is a feared sequelae of malignant paediatric brain tumours. Current methods for its detection is the combined use of cranio-spinal MRI, and CSF cytology from a post-operative lumbar puncture. In this study, the authors hypothesize that CSF taken at the start of surgery, either from an external ventricular drain or neuroendoscope will have equal sensitivity for positive tumour cells, in comparison to lumbar puncture. Secondary hypotheses include positive correlation between CSF cytology and MRI findings of LMD...
2018: PloS One
https://www.readbyqxmd.com/read/29627632/giant-sacral-schwannoma-treated-with-a-360-approach-a-rare-case-and-systematic-review-of-the-literature
#6
REVIEW
Ursalan Ahmed Khan, Ghiath Ismayl, Irfan Malik
Sacral schwannomas are very rare and typically have a benign nature. They occur in a permissive anatomical location leading to non-specific symptoms which can result in them going unnoticed before reaching a considerable size. We report a rare case of a giant sacral schwannoma (130x110x90mm) in a 38-year-old man originating from the S2 nerve root, encompassing the neural canal with sacral erosion and extension in to the pelvis. The patient presented with a history of abdominal pain associated with increased urinary frequency and a sensation of incomplete bladder emptying...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29627630/awake-intradural-spinal-tumour-resection
#7
Anan Shtaya, Chan Bao Luong, Erlick Pereira
BACKGROUND: Meningioma is a common slow growing spinal tumour with a predilection for intradural occurrence. Patients usually present with pain followed by ataxia and sensory and sphincter problems. The gold standard treatment in these cases is gross total microsurgical resection under general anaesthesia. However, there exist high anaesthetic risk patients unsuitable for general anaesthesia. Performing spinal surgeries under local anaesthesia and sedation has been reported albeit rarely for mostly minimally invasive procedures but not for open intradural pathologies...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29619522/solitary-fibrous-tumour-of-the-spine-imaging-features-of-a-commonly-misdiagnosed-entity
#8
Ning Lang, Enlong Zhang, Xiaoying Xing, Huishu Yuan
OBJECTIVE: Solitary fibrous tumours (SFTs) occurring in the spine are rare. Herein, we review the clinical and imaging data of spinal SFT. METHODS: We retrospectively analysed eight cases of pathologically confirmed spinal SFT imaging and clinical data, pathological manifestations, surgical methods, and follow-up results. RESULTS: Five SFTs cases occurred in the cervical spine, two in the thoracic spine, and one in the lumbosacral spine. Five cases showed a dumbbell-shaped or lobulated soft tissue mass that grew across the intervertebral foramen, two cases showed an expansive intraosseous mass formation in the vertebral body and/or posterior element, and one case showed a long-spindle shaped intraspinal canal mass growing along the spinal canal...
April 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29602695/-radiotherapy-of-bone-metastases-in-france-a-descriptive-monocentric-retrospective-study
#9
C Le Fèvre, D Antoni, A Thiéry, A Keller, P Truntzer, C Vigneron, J-B Clavier, S Guihard, M Pop, C Schumacher, P Salze, G Noël
PURPOSE: Bone metastases cause pain and affect patients' quality of life. Radiation therapy is one of the reference analgesic treatments. The objective of this study was to compare the current practices of a French radiotherapy department for the treatment of uncomplicated bone metastases with data from the literature in order to improve and optimize the management of patients. MATERIAL AND METHODS: A retrospective monocentric study of patients who underwent palliative irradiation of uncomplicated bone metastases was performed...
March 27, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29581892/primary-intramedullary-spinal-cord-tumour-in-pregnancy-a-case-report
#10
Kyoko Fujii, Makoto Orisaka, Makoto Yamamoto, Koji Nishijima, Yoshio Yoshida
Introduction: Primary spinal cord tumours can lead to severe neurological complications and even death. Pregnant women often complain of discomfort of the lower limbs, which is usually caused by sciatica. Here we present the case of a pregnant woman, who was initially considered to have sciatica, but was finally diagnosed with a primary intramedullary spinal cord tumour. Case presentation: A 28-year-old pregnant woman presented to our hospital with inexplicable numbness in her lower limbs...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29559217/solitary-fibrous-tumour-haemangiopericytoma-of-the-spinal-cord
#11
Ana Flores-Justa, Elena López-García, Alfredo García-Allut, Rosa María Reyes-Santías
Solitary fibrous tumours/haemangiopericytomas (SFT/HPC) are fibroblastic mesenchymal neoplasms that harbour a genetic fusion of NAB2/STAT6. There are few reported cases in the central nervous system (CNS), of which spinal tumours are minority. We present a case of a 63-year-old woman with progressive paraparesis and a sensory level of T6. On the MRI we detected an intradural extramedullary lesion on T9-T10. We performed a laminectomy with an intraoperative ultrasound study in which we observed a heterogeneous lesion with an infiltrating pattern affecting the medulla at several points, and resection of the lesion...
March 17, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29549906/prediction-of-survival-in-patients-with-symptomatic-spinal-metastases-comparison-between-the-tokuhashi-score-and-expert-oncologists
#12
Kenny Yat Hong Kwan, Tai Chung Lam, Horace Cheuk Wai Choi, Hui Yu Koh, Kenneth Man Chee Cheung
BACKGROUND: Existing scoring systems have suboptimal accuracy in prognosticating patients with spinal metastases. Currently, there is no superior method in predicting survival. This study aims to compare the accuracy of survival prediction by expert oncologists versus the revised Tokuhashi scores with actual survivals in a cohort of symptomatic spinal metastases patients. METHODS: All patients who underwent surgical treatment for metastatic spinal tumours in a tertiary hospital between January 2011 to December 2015 were reviewed...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29530807/withdrawn-minocycline-an-antimicrobial-agent-attenuates-the-mitochondrial-dependent-cell-death-and-stabilizes-the-expression-of-hif-1%C3%AE-in-spinal-cord-injury
#13
Guolei Zhang, Junpu Zha, Junchuan Liu, Jun Di
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
March 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29497859/transurethral-resection-of-bladder-cancer-on-the-lateral-bladder-wall-without-obturator-nerve-block-extent-of-adductor-spasms-using-the-monopolar-versus-bipolar-technique-a-prospective-randomised-study
#14
T Gramann, C Schwab, V Zumstein, P Betschart, M Meier, H-P Schmid, D S Engeler
PURPOSE: To establish whether bipolar transurethral resection of tumours (bTURB) on the lateral bladder wall is superior to monopolar transurethral resection (mTURB) of such tumours. To our knowledge, this is the first prospective randomised study, which defines complete resection depending on obturator jerk as primary endpoint. METHODS: In a prospective, randomised, single centre study, 52 patients with newly diagnosed or recurrent bladder tumour on the lateral bladder wall were enrolled and randomised to undergo mTURB or bTURB; 44 patients were eligible for analysis, of whom 21 underwent mTURB and 23 bTURB...
March 1, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29497125/critical-role-of-sigma-1-receptors-in-central-neuropathic-pain-related-behaviours-after-mild-spinal-cord-injury-in-mice
#15
Sílvia Castany, Georgia Gris, José Miguel Vela, Enrique Verdú, Pere Boadas-Vaello
Sigma-1 receptor (σ1 R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in wild type (WT) mice were done to investigate the role of this receptor in the development of pain-related behaviours (thermal hyperalgesia and mechanical allodynia) in mice after spinal cord contusion injury (SCI) - a model of central neuropathic pain. The modulatory effect of σ1 R KO on extracellular mediators and signalling pathways in the spinal cord was also investigated. In particular, changes in the expression of inflammatory cytokines (tumour necrosis factor TNF-α, interleukin IL-1β) and both the expression and activation (phosphorylation) of the N-methyl-D-aspartate receptor subunit 2B (NR2B-NMDA) and extracellular signal-regulated kinases (ERK1/2) were analysed...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29484025/acrocyanosis-a-symptom-with-many-facettes
#16
REVIEW
Uwe Wollina, André Koch, Dana Langner, Gesina Hansel, Birgit Heinig, Torello Lotti, Georgi Tchernev
Acrocyanosis is an uncommon complaint belonging to the acro-syndromes. It typically presents with coolness and bluish discolourations of hands, feet, ears, nose, lips and nipple. The most frequently affected parts of the body are the hands. This review discusses physical factors, vascular disorders, infectious diseases, haematological disorders, solid tumours genetic disorders, drugs, eating disorders, and spinal disease presenting as or leading to acrocyanosis.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29472020/sudden-paraplegia-due-to-spontaneous-bleeding-in-a-thoracic-epidural-angiolipoma-and-literature-review
#17
M Lacour, V Gilard, F Marguet, S Curey, A Perez, S Derrey
BACKGROUND: Spinal angiolipomas are rare epidural tumours that are usually revealed by chronic symptoms of medullar irritation. We report a case of acute paraplegia caused by spontaneous bleeding revealing a thoracic angiolipoma. CASE DESCRIPTION: A 17-year-old male patient with no previous medical history was admitted for acute onset of paraplegia with bladder retention and loss of sensation in the lower limbs, preceded by dorsal pain during the three previous days...
March 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29455490/-clinical-application-of-anterior-thoracoscopically-assisted-surgery-with-posterior-one-stage-total-en-block-spondylectomy-for-thoracic-spinal-tumor
#18
Wen Xue, Xiao-Li Guan, Zeng-Ping Wang, Zhong-Yu Hao, Lin Liu, Yao-Wen Qian
OBJECTIVE: To investigate the clincial effects and feasibility of anterior thoracoscopically assisted surgery (TAS) with posterior one-stage total en block spondylectomy(TES) for thoracic spinal tumour. METHODS: From October 2014 to January 2016, 4 patients with thoracic spinal tumour were treated by anterior thoracoscopically assisted surgery with posterior one-stage total en block spondylectomy. There were 2 males and 2 females, aged 16, 35, 46, 60 years. Courses of disease were 1, 4, 6, 9 months...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29454959/exophytic-cerebral-hemispheric-low-grade-glioma-unusual-growth-pattern-of-common-central-nervous-system-tumor
#19
Suyash Singh, Kuntal Kanti Das, Sushila Jaiswal, Raj Kumar
BACKGROUND: Exophytic growth (EG), wherein the tumor mass grows beyond the neuraxial boundary formed by pia mater, remains a rare pattern of glioma growth. It has been described in gliomas at several locations like the brainstem, cerebellum, suprasellar area, spinal cord, and insula. However, EG in hemispheric grade 2 astrocytomas, particularly affecting the convexity subarachnoid space, as against the more spacious basal subarachnoid space, is exceedingly rare. To the best of our knowledge, there is only 1 such case reported in the English literature...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29445946/paravertebral-tumours-of-the-cervicothoracic-junction-extending-into-the-mediastinum-surgical-strategies-in-a-no-man-s-land
#20
Georgios K Prezerakos, Parag Sayal, Antonios Kourliouros, Periclis Pericleous, George Ladas, Adrian Casey
PURPOSE: Cervicothoracic paravertebral neoplasms extending into the mediastinum pose a surgical challenge due the complex regional anatomy, their biological nature, rarity and surgeon's unfamiliarity with the region. We aim to define a surgical access framework addressing the aforementioned complexities whilst achieving oncological clearance. METHODS: We carried out a retrospective review of 28 consecutive patients operated in two tertiary referral centres between 1998 and 2015...
April 2018: European Spine Journal
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