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Abdallah Al-Salameh, Camille Baudry, Régis Cohen
Multiple endocrine neoplasia type 1 is a rare genetic syndrome, characterized by the co-occurrence, in the same individual or in related individuals of the same family, of hyperparathyroidism, duodenopancraetic neuroendocrine tumors, pituitary adenomas, adrenocortical tumors, and neuroendocrine tumors (carcinoids) in the thymus, the bronchi, or the stomach. Multiple endocrine neoplastic type 2 is a rare genetic syndrome, characterized by the familial occurrence of medullary thyroid carcinoma either isolated or associated with pheochromocytoma, primary hyperparathyroidism, or typical features (Marfanoid habitus, mucosal neuromas)...
June 13, 2018: La Presse Médicale
Kotaro Miyake, Osamu Morimura, Takako Inoue, Kenya Yoshida, Izumi Nagatomo, Takashi Kijima, Atsushi Kumanogoh
BACKGROUND: The purpose of this study was to identify bronchi on computed tomographic (CT) images, manual analysis is more accurate than automatic methods. Nonetheless, manual bronchoscopic navigation is not preferred as it involves mentally reconstructing a route to a bronchial target by interpreting 2-dimensional CT images. Here, we established the direct oblique method (DOM), a form of manual bronchoscopic navigation that does not necessitate mental reconstruction, and compared it with automatic virtual bronchoscopic navigation (VBN)...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
Femke van der Stelt, Gregor J Krings, Mirella C Molenschot, Johannes M Breur
AIMS: Complex single ventricle topography, changes in vessel geometry after surgical steps and subsequent stenoses are difficult to visualise with biplane conventional angiography (CA). This study investigated the additional value of three-dimensional rotational angiography (3DRA) compared to CA for diagnostic and interventional purposes in children with univentricular hearts. METHODS AND RESULTS: Demographic data, clinical data and catheterisation details of both imaging techniques were collected retrospectively...
June 12, 2018: EuroIntervention
S R Devarajan, N Zarrin-Khameh, P Alapat
We present a case of a 76 year-old, non-smoking Honduran female who was referred to our clinic for years of persistent dry cough. Cardiac evaluation was unremarkable. She denied symptoms of heartburn, allergic rhinitis, and there was no personal or family history of asthma. Her physical exam demonstrated wheezing over the right mid-posterior chest. Spirometry was within normal limits. CT-imaging of the chest demonstrated right middle lobe bronchus and lingular segmental bronchus narrowing with bibasilar atelectasis and mild interlobular septal thickening with prominent mediastinal adenopathy...
2018: Respiratory Medicine Case Reports
Alexandr Evgen'evich Mashkov, Dmitrii Anatolèvich Pykchteev, Alexandr Viktorovic Sigachev, Andrei Viktorovich Bobylev, Johannes Michael Mayr
RATIONALE: Esophageal achalasia is characterized by impaired relaxation of the cardia and dilation of the intrathoracic part of the esophagus. We describe the late presentation of achalasia in an 11-year old girl. PATIENT CONCERNS: She suffered from recurrent pneumonia, obstructive bronchitis, and problems with swallowing solid food. Her family noted a wet pillow in the morning. DIAGNOSES: This case report describes the typical symptoms of achalasia in children in order to facilitate earlier diagnosis of this rare disease...
June 2018: Medicine (Baltimore)
Xianghuai Xu, Qiang Chen, Zhongmin Qiu, Cuiqin Shi, Hongmei Ding, Lan Wang, Hanjing Lv, Li Yu
Objective This study was performed to establish a novel model of citric acid-induced chronic cough in guinea pigs and to investigate the pathogenesis of cough hypersensitivity. Methods Healthy conscious guinea pigs inhaled citric acid (0.4 M) for 3 minutes twice daily for 25 days. Cough reactivity was evaluated, substance P (SP) and calcitonin gene-related peptide (CGRP) in bronchoalveolar lavage fluid were detected, and transient receptor potential cation channel subfamily V member 1 (TRPV1) protein expression in the trachea and bronchus was determined...
January 1, 2018: Journal of International Medical Research
Wu-Lin Zuo, Sushila A Shenoy, Sheng Li, Sarah L O'Beirne, Yael Strulovici-Barel, Philip L Leopold, Guoqing Wang, Michelle R Staudt, Matthew S Walters, Christopher Mason, Robert J Kaner, Jason G Mezey, Ronald G Crystal
RATIONALE: Little is known about human club ("Clara") cells, dome shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small air-ways (≥6th generation bronchi). OBJECTIVE: To define the ontogeny and biology of the human small airway epithelium club cell. METHODS: The small airway epithelium was sampled from the normal human lung by bronchoscopy and brushing. Single cell transcriptome analysis and air-liquid interface culture was used to assess club cell ontogeny and biology...
June 6, 2018: American Journal of Respiratory and Critical Care Medicine
Shadi Hamouri, Faisal Swesi, Nathan Michael Novotny
BACKGROUND: Headscarf use is becoming more common throughout the world. Many articles describe the problem of aspirated headscarf pins but few if any give technical details for retrieval or innovative methods of removal if traditional bronchoscopy fails particularly in the pediatric population. Herein, we describe our method of deep sedation with laryngeal mask airway (LMA) and flexible bronchoscopy (FB) and retrieval with a stepwise algorithm if traditional FB fails. METHODS: A retrospective review of pediatric patients with aspirated headscarf pins was performed...
June 6, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Y L Li, M Z Wu, X M Chai, J Xu
Objective: To investigate the imaging findings of juvenile laryngeal papilloma spreading in the bronchia and lung with spiral CT. Method: Seven cases of juvenile laryngeal papilloma spreading in bronchia and lung were collected.All cases were confirmed by operation and pathology. Spiral CT scans were performed in seven cases, contrast scanning were performed in three cases. MPR were performed in two cases. Imaging findings in all cases were retrospectively reviewed. Result: Findings of CT scan in seven patients showed scattered and multiple, unequal-sized nodular shadows and airbag cavity, randomly distributed in the centre and peripheral of lung along the airway, the nodules are homogeneous soft tissue density or liquid density; with air cavity are sac, available for thin-walled cystic wall, or a thick wall, give priority to with thin wall, most of the capsule wall were smooth, part of vesicles were connected to the bronchi, seldom complicated with lung inflammation...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Lara Carolina Mario, Jéssica Borghesi, Rafael G Hayashi, Phelipe O Favaron, Marcio N Rodrigues, Rafael C Carvalho, Maria A Miglino
Rodents are important in the transmission of infectious diseases that affect the respiratory tract, including simple infections and those caused by specific pathogens. These animals are natural reservoirs of zoonoses that cause many public health diseases. Basic knowledge on the morphology of these animals is important as basic research is useful for applied studies, such as the development of clinical, therapeutic, surgical and clinical models. Morphological data of respiratory tract in Oligoryzomys nigripes are absent in the literature...
June 4, 2018: Anatomia, Histologia, Embryologia
Hui-Qiang Wei, Xiao-Gang Guo, Gong-Bu Zhou, Qi Sun, Jian-Du Yang, Bin Luo, Jian Ma
INTRODUCTION: Access the predictors of hemoptysis using second-generation cryoballoon (CB). METHODS: Thirty patients with hemoptysis after second-generation CB ablation and 60 age-, gender-, and body mass index-matched controls were recruited. Anatomic parameters were obtained from pre-procedural cardiac computed tomography (CT). Pulmonary vein isolation was performed with 28-mm balloon using single 3-minute freeze technique. RESULTS: Clinical and procedural characteristics were similar between the groups...
June 2, 2018: Journal of Cardiovascular Electrophysiology
Masahiro Yanagawa, Akinori Hata, Osamu Honda, Noriko Kikuchi, Tomo Miyata, Ayumi Uranishi, Shinsuke Tsukagoshi, Noriyuki Tomiyama
OBJECTIVES: To compare the image quality of the lungs between ultra-high-resolution CT (U-HRCT) and conventional area detector CT (AD-CT) images. METHODS: Image data of slit phantoms (0.35, 0.30, and 0.15 mm) and 11 cadaveric human lungs were acquired by both U-HRCT and AD-CT devices. U-HRCT images were obtained with three acquisition modes: normal mode (U-HRCT N : 896 channels, 0.5 mm × 80 rows; 512 matrix), super-high-resolution mode (U-HRCT SHR : 1792 channels, 0...
May 29, 2018: European Radiology
Saibin Wang, Qian Ye, Junwei Tu, Yong Song
Background: Several risk factors have been proposed for bleeding during bronchoscopy, including immunosuppression, thrombocytopenia, pulmonary arterial hypertension, and mechanical ventilation. However, research on bronchoscopic biopsy-induced bleeding in the population of lung cancer without these "proposed risk factors" remains lacking. Patients and methods: A total of 531 lung cancer patients with endobronchial biopsy (EBB) were enrolled in this retrospective observational study...
2018: Cancer Management and Research
Zsófia Lázár, Ágnes Kelemen, Gabriella Gálffy, György Losonczy, Ildikó Horváth, András Bikov
Nitrative stress pathways are involved in airway inflammation characterizing chronic obstructive pulmonary disease (COPD). Extended nitric oxide (NO) analysis allows the partitioned measurement of nitrative stress in the conducting bronchi and peripheral airways/alveolar spaces. However, pulmonary NO production at these two sites has not been systemically studied in stable and exacerbated COPD. Twenty-eight patients with stable COPD, 34 patients during an exacerbation, and 15 smoking controls were recruited...
May 29, 2018: Journal of Breath Research
Jose Montoya Segnini, Humberto Bocanegra Evans, Luciano Castillo
BACKGROUND: Despite the prevailing assumption of "smooth trachea walls" in respiratory fluid dynamics research, recent investigations have demonstrated that cartilaginous rings in the trachea and main bronchi have a significant effect on the flow behavior and in particle deposition. However, there is not enough detailed information about the underlying physics of the interaction between the cartilage rings and the flow. MATERIALS AND METHODS: This study presents an experimental observation of a simplified Weibel-based model of the human trachea and bronchi with cartilaginous rings...
May 23, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Ravishankar Chandrasekaran, Micheál Mac Aogáin, James D Chalmers, Stuart J Elborn, Sanjay H Chotirmall
Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations...
May 22, 2018: BMC Pulmonary Medicine
Pascal-Alexandre Thomas
Appropriate lymph node (LN) assessment is a hallmark of surgical quality of curative intent operations for non-small cell lung cancer (NSCLC). Even in the era of extensive pre-treatment work-up including routine PET-scanning and brain imaging, and selective invasive LN evaluation, unexpected LN metastases are found at surgery in more than 10% of patients with a cT1aN0 tumor. Systematic lymphadenectomy minimizes the risk of leaving tumor-LN behind and thus the risk of an incomplete resection, and provides the most truthful pTNM, which is decisive in directing adjuvant chemotherapy...
April 2018: Journal of Thoracic Disease
Min Jae Cha, Hyun Jeong Park, Mun Young Paek, Alto Stemmer, Eun Sun Lee, Sung Bin Park, Yang Soo Kim
OBJECTIVES: To investigate the diagnostic accuracy of lung magnetic resonance imaging (MRI) with a free-breathing three-dimensional ultrashort echo time spoiled gradient echo sequence using a stack-of-spirals acquisition (spiral 3D UTE) for pulmonary nodule detection at 3 T in oncology patients. METHODS: The institutional review board approved this retrospective study. Between June and September of 2017, 32 oncology patients underwent both free-breathing spiral 3D UTE of the lungs and thin-section chest computed tomography (CT) for pulmonary metastasis workups...
May 15, 2018: Magnetic Resonance Imaging
N Nawshin, S Mannan, M F Kamal, E Z Epsi, Z Ahmed
The respiratory system is involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment which is essential for human survival. The bronchial tree includes the trachea, right and left principal bronchi and their branching upto alveoli. A common medical problem with the respiratory tract is acute respiratory tract infection (ARI) which is the leading killer of children under five. The aim of the present study was to find out the variation of the luminal diameter of right principal bronchus in Bangladeshi people...
April 2018: Mymensingh Medical Journal: MMJ
Kazuki Hayashi, Makoto Motoishi, Kanna Horimoto, Satoru Sawai, Jun Hanaoka
BACKGROUND: A displaced bronchus is a rare disorder of the left upper lobe. Displaced bronchi are often accompanied by an anomaly of a pulmonary artery, but rarely of a pulmonary vein. CASE PRESENTATION: We here present a patient with primary lung cancer and simultaneous migration abnormalities of the pulmonary artery and vein in a displaced bronchus of the left upper lobe. Previous reports and our findings indicate that anomalies of the pulmonary artery and vein combined with a displaced bronchus of the left upper lobe have the following characteristics: (1) the left main pulmonary artery does not cross the dorsal side of the displaced bronchus; (2) V1 + 2 returns to the inferior pulmonary vein; and (3) there is an accessory fissure (aberrant fissure) in the segments dominated by the displaced bronchus...
May 16, 2018: Journal of Cardiothoracic Surgery
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