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https://www.readbyqxmd.com/read/29444178/heterogeneity-in-pulmonary-emphysema-analysis-of-ct-attenuation-using-gaussian-mixture-model
#1
Mizuho Nishio, Yutaka Tanaka
PURPOSE: To utilize Gaussian mixture model (GMM) for the quantification of chronic obstructive pulmonary disease (COPD) and to evaluate the combined use of multiple types of quantification. MATERIALS AND METHODS: Eighty-seven patients (67 men, 20 women; age, 67.4 ± 11.0 years) who had undergone computed tomography (CT) and pulmonary function test (PFT) were included. The heterogeneity of CT attenuation in emphysema (HC) was obtained by analyzing a distribution of CT attenuation with GMM...
2018: PloS One
https://www.readbyqxmd.com/read/29436277/initial-load-stability-of-different-trachea-suture-techniques-tests-on-an-ex-vivo-model
#2
Andreas Kirschbaum, Helen Abing, Nikolas Mirow
Objective Tracheal anastomosis can be performed with different suture techniques. In this experimental work, the resilience of anastomotic techniques to pressure and tensile stress was studied. Study Design Ex vivo pig model. Setting Experimental. Subjects and Methods The trachea with the 2 main bronchi in freshly slaughtered pigs was isolated and intubated (CH 8.0). Both main bronchi were closed distally by a stapler. After resection of the trachea, an anastomosis (n = 15 per group) was created: group 1, single interrupted sutures; group 2, continuous running suture; group 3, mixed technique...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29429996/application-of-light-sheet-microscopy-for-qualitative-and-quantitative-analysis-of-bronchus-associated-lymphoid-tissue-in-mice
#3
David Twapokera Mzinza, Henrike Fleige, Kristin Laarmann, Stefanie Willenzon, Jasmin Ristenpart, Julia Spanier, Gerd Sutter, Ulrich Kalinke, Peter Valentin-Weigand, Reinhold Förster
Bronchus-associated lymphoid tissue (BALT) develops at unpredictable locations around lung bronchi following pulmonary inflammation. The formation and composition of BALT have primarily been investigated by immunohistology that, due to the size of the invested organ, is usually restricted to a limited number of histological sections. To assess the entire BALT of the lung, other approaches are urgently needed. Here, we introduce a novel light sheet microscopy-based approach for assessing lymphoid tissue in the lung...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429215/-a-clinican-linical-analysis-of-29-cases-of-chronic-pulmonary-aspergillosis
#4
L Y Xu, G X Lai, Q Hu, L Zhang, D L Liu, G B Zhu, X H Li, H H Shi, C Xu, Y H Yu, Y W Bao, W Chen
Objective: To improve the understanding of chronic pulmonary aspergillosis (CPA) by analyzing the clinical manifestations, imaging and pathological features, diagnosis, treatment and prognosis of this disease. Methods: Cases of CPA, proven by microbiological evidence based on pathological study in Fuzhou General Hospital of the People's Liberation Army and Affiliated Fuzhou City First Hospital of Fijian Medical University from January 2006 to October 2016 were retrospectively analyzed. Results: The patients consisted of 17 males and 12 females, aged 24 to 75 years, mean (42±16) years...
February 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29415434/pathogenesis-and-animal-models-of-post-primary-bronchogenic-tuberculosis-a-review
#5
REVIEW
Robert L Hunter, Jefrey K Actor, Shen-An Hwang, Arshad Khan, Michael E Urbanowski, Deepak Kaushal, Chinnaswamy Jagannath
Primary and post-primary tuberculosis (TB) are different diseases caused by the same organism. Primary TB produces systemic immunity. Post-primary TB produces cavities to support massive proliferation of organisms for transmission of infection to new hosts from a person with sufficient immunity to prevent systemic infection. Post-primary, also known as bronchogenic, TB begins in humans as asymptomatic bronchial spread of obstructive lobular pneumonia, not as expanding granulomas. Most lesions regress spontaneously...
February 6, 2018: Pathogens
https://www.readbyqxmd.com/read/29412280/palliative-therapy-in-adults-with-cancer-a-cross-sectional-study
#6
Angelita Visentin, Maria de Fátima Mantovani, Luciana Puchalski Kalinke, Shirley Boller, Leila Maria Mansano Sarquis
OBJECTIVE: To characterize the socioeconomic and clinical profile of adult cancer patients in palliative therapy. METHOD: Cross-sectional study in an oncology hospital in Paraná, with 124 adult patients who started palliative therapy in the period from Jan. 2 to June 30, 2015. RESULTS: Of the participating population, 60.5% were women, 68.5% white, 48.4% married, 72.6% catholic and with income of one to two minimum wages. Non-smokers, 45...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29408983/extended-sleeve-lobectomy-for-centrally-located-non-small-cell-lung-cancer-a-20-year-single-centre-experience
#7
Tae Hee Hong, Jong Ho Cho, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim, Jhingook Kim
OBJECTIVES: Extended sleeve lobectomy (ESL), an atypical bronchoplasty with resection of more than 1 lobe, might be technically demanding but has certain theoretical advantages, including the avoidance of pneumonectomy. However, clinical outcomes after ESL are not well known. METHODS: Between March 1995 and December 2015, 540 patients with centrally located non-small-cell lung cancer underwent sleeve resection. Among them, 63 patients underwent an ESL procedure...
February 2, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29408044/effect-of-lipopolysaccharide-on-the-responsiveness-of-equine-bronchial-tissue
#8
Luigino Calzetta, Paola Rogliani, Elena Pistocchini, Maurizio Mattei, Giuseppe Cito, Pietro Alfonsi, Clive Page, Maria Gabriella Matera
Recurrent airway obstruction (RAO) is a main characteristic of horses with severe equine asthma syndrome. The presence of bacterial lipopolysaccharide (LPS) in the airways of horses is thought to play a crucial role in the clinical expression of this disorder. This study pharmacologically characterized the effect of LPS on the responsiveness of equine bronchial tissue. Equine isolated bronchi were incubated overnight with LPS (0.1-100 ng/ml) and then stimulated by electrical field stimulation (EFS). The role of capsaicin sensitive-sensory nerves (capsaicin desensitization treatment), neurokinin-2 (NK2) receptors (blocked by GR159897), transient receptor potential vanilloid type 1 receptors (TRPV1; blocked by SB366791), and neurokinin A (NKA) were investigated...
January 30, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29397926/bronchial-mismatch-as-a-predictor-of-respiratory-failure-after-congenital-tracheal-stenosis-repair
#9
Enrico Cetrano, Matteo Trezzi, Aurelio Secinaro, Luca Di Chiara, Marilena Trozzi, Sergio Bottero, Angelo Polito, Adriano Carotti
BACKGROUND: The purpose of this study was to identify predictors of postoperative respiratory failure after surgical tracheoplasty for congenital tracheal stenosis. METHODS: Between February 2011 and April 2017, 16 infants underwent congenital tracheal stenosis repair. Preoperative computed tomography evaluation of the trachea and mainstem bronchi was performed. The primary outcome was midterm freedom from postoperative respiratory failure defined as persistent need for mechanical ventilation or surgical tracheobronchial reoperation...
February 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29397088/management-of-acute-cough-by-zataria-multiflora-boiss-as-an-alternative-treatment
#10
REVIEW
Mohaddese Mahboubi
Cough, as a defensive reflux mechanism, removes foreign objects and secretions from bronchi and bronchioles of airways. Zataria multiflora is a popular plant for treatment of cough in Iranian traditional medicine. The aim of this review was to evaluate the potency of Z. multiflora as an alternative treatment in management of acute cough and its possible mechanisms of action. Here the authors compiled information about Z. multiflora in the treatment of cough from all accessible resources and books. The results of this investigation showed that there were five clinical studies that evaluated the efficacy of Z...
January 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29394980/endobronchial-mucosal-neuroma-with-sarcoidosis
#11
Ipek Erdem, Dildar Duman, Selma Eroglu, Meltem Agca, Aykut Erdagi, Hatice Turker, Armagan Hazar
A first case of endobronchial mucosal neuroma with sarcoidosis is hereby reported. A 67-year female patient, who was diagnosed as sarcoidosis previously, was admitted to our hospital with symptoms of dyspnea, chest pain and fatigue. Middle lobe atelectasis and endobronchial lesion were observed in thorax computed tomography (CT). Fiberoptic bronchoscopy revealed polypoid lesions and histopathological examination of biopsy material showed clustered nerve bundles consistent with mucosal neuroma and non-necrotising granulomas consistent with sarcoidosis...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29390485/antiangiogenic-therapy-for-primitive-neuroectodermal-tumor-with-thalidomide-a-case-report-and-review-of-literature
#12
REVIEW
Qing Li, Yong Liu, Yang Yu
RATIONALE: Peripheral primitive neuroectodermal tumor (PNET) is a kind of small round cell tumor derived from primitive neuroectodermal tumor. PATIENT CONCERNS: PNET is a highly malignant tumor that is subordinated to Ewing sarcoma. It occurs predominantly in soft tissue and bone and rarely in the bronchi and lung. Traditional surgery, radiotherapy, and chemotherapy are used for the treatment of PNET, but are usually ineffective. DIAGNOSES: There was a rare case of a 17 year-old man diagnoses with primary pulmonary PNET...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384478/discrimination-between-bycatch-and-other-causes-of-cetacean-and-pinniped-stranding
#13
Yara Bernaldo de Quirós, Meghan Hartwick, David S Rotstein, Michael M Garner, Andrea Bogomolni, William Greer, Misty E Niemeyer, Greg Early, Frederick Wenzel, Michael Moore
The challenge of identifying cause of death in discarded bycaught marine mammals stems from a combination of the non-specific nature of the lesions of drowning, the complex physiologic adaptations unique to breath-holding marine mammals, lack of case histories, and the diverse nature of fishing gear. While no pathognomonic lesions are recognized, signs of acute external entanglement, bulging or reddened eyes, recently ingested gastric contents, pulmonary changes, and decompression-associated gas bubbles have been identified in the condition of peracute underwater entrapment (PUE) syndrome in previous studies of marine mammals...
January 31, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29383594/detection-of-alternative-subpleural-lymph-flow-pathways-using-indocyanine-green-fluorescence
#14
Aya Harada Takeda, Yui Watanabe, Toshiyuki Nagata, Masaya Aoki, Tadashi Umehara, Soichi Suzuki, Go Kamimura, Kazuhiro Wakida, Tsunayuki Otsuka, Naoya Yokomakura, Kota Kariatsumari, Koichi Sakasegawa, Yoshihiro Nakamura, Masami Sato
PURPOSE: Pulmonary lymphatic fluid predominately flows along the bronchi. However, there are reports suggesting that an alternative lymphatic pathway exist, which may result in skip metastases. The aim of this study was to evaluate the subpleural lymph flow in vivo using indocyanine green (ICG) fluorescence. METHODS: One hundred cases were enrolled. ICG was injected into the macroscopically healthy subpleural space. Intraoperative fluorescence images were then observed in real time...
January 30, 2018: Surgery Today
https://www.readbyqxmd.com/read/29383501/parasites-of-small-indian-mongoose-herpestes-auropunctatus-on-st-kitts-west-indies
#15
Trista Cheng, Brandon Halper, Jennifer Siebert, Luis Cruz-Martinez, Aspinas Chapwanya, Patrick Kelly, Jennifer K Ketzis, Jeffrey Vessell, Liza Köster, Chaoqun Yao
Herpestes auropunctatus, the small Indian mongoose, is an invasive omnivore introduced to the Caribbean, including the island of St. Kitts over 150 years ago. It has played a role in changing native fauna and can carry zoonotic pathogens of public health importance. The aim of the current study was to estimate the prevalence of parasites harbored by mongooses. In total, 87 mongooses trapped from April to July 2015 were examined for parasites using (1) hair plucks (N = 79), ear swabs (N = 79), and general coat and skin examination (N = 87) for mites, ticks, lice, and fleas; (2) dissection of the trachea, bronchi, and lungs for lungworms and flukes (N = 76); (3) a double centrifugation fecal flotation method for parasites of the gastrointestinal tract (N = 75); and (4) PCR of heart homogenates for Toxoplasma gondii (N = 60)...
January 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29379233/radiological-spectrum-of-anthracofibrosis-a-series-of-40-patients-with-computed-tomography-bronchoscopy-and-biopsy
#16
Anandamoyee Dhar, Kunal Sikund, Ajal Lall, Bharat Aggarwal
Introduction: Anthracofibrosis is a lesser known clinical entity. Patients present with chronic symptoms of cough and breathlessness with a history of biofuel/wood fire smoke exposure. There are distinct computed tomography (CT) imaging features of anthracofibrosis that can differentiate it from more common conditions such as tuberculosis (TB) and bronchogenic carcinoma. Findings include multifocal noncontiguous stenosis of bronchial tree, calcified enlarged mediastinal or hilar nodes, and secondary lung parenchymal changes...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29377399/a-systematic-review-of-pyoderma-gangrenosum-with-pulmonmary-involvement-clinical-presentation-diagnosis-and-management
#17
Angela S Gupta, Teri Greiling, Alex G Ortega-Loayza
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that often has extracutaneous manifestations, with lung involvement being the most common (1, 2). In this systematic review we have summarized the clinical presentation, predisposing factors, and treatment of PG patients with pulmonary involvement and compared them to classic neutrophilic disorders. Using the search terms "pulmonary, lung, respiratory, bronchi, or bronchopulmonary" AND "pyoderma gangrenosum" a systematic review was conducted using PubMed and Web of Science...
January 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29373211/effect-of-matrix-size-on-the-image-quality-of-ultra-high-resolution-ct-of-the-lung-comparison-of-512%C3%A2-%C3%A3-%C3%A2-512-1024%C3%A2-%C3%A3-%C3%A2-1024-and-2048%C3%A2-%C3%A3-%C3%A2-2048
#18
Akinori Hata, Masahiro Yanagawa, Osamu Honda, Noriko Kikuchi, Tomo Miyata, Shinsuke Tsukagoshi, Ayumi Uranishi, Noriyuki Tomiyama
RATIONALE AND OBJECTIVES: This study aimed to assess the effect of matrix size on the spatial resolution and image quality of ultra-high-resolution computed tomography (U-HRCT). MATERIALS AND METHODS: Slit phantoms and 11 cadaveric lungs were scanned on U-HRCT. Slit phantom scans were reconstructed using a 20-mm field of view (FOV) with 1024 matrix size and a 320-mm FOV with 512, 1024, and 2048 matrix sizes. Cadaveric lung scans were reconstructed using 512, 1024, and 2048 matrix sizes...
January 16, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29362199/tracheobronchopathia-osteochondroplastica-as-a-single-mass-in-lingular-bronchus
#19
Niravkumar K Sangani, Santosh Mathew Naliath
We describe a rare case of tracheobronchopathia osteochondroplastica (TBO) in a 35-year-old man who presented with recurrent chest infection and hemoptysis. Bronchoscopy and computed tomography scan revealed a single 1.5-cm hard nodular mass lesion in the lingular bronchus associated with collapse and bronchiectasis of the lingula. The patient underwent open left lingulectomy with removal of the mass. Histopathology of the lesion showed characteristic features of TBO. TBO is generally characterized by multiple nodules in the trachea or main bronchi...
February 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29344809/regeneration-of-functional-alveoli-by-adult-human-sox9-airway-basal-cell-transplantation
#20
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition...
January 17, 2018: Protein & Cell
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