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https://www.readbyqxmd.com/read/28077740/the-jarisch-herxheimer-reaction-after-antibiotic-treatment-of-spirochetal-infections-a-review-of-recent-cases-and-our-understanding-of-pathogenesis
#1
REVIEW
Thomas Butler
Within 24 hours after antibiotic treatment of the spirochetal infections syphilis, Lyme disease, leptospirosis, and relapsing fever (RF), patients experience shaking chills, a rise in temperature, and intensification of skin rashes known as the Jarisch-Herxheimer reaction (JHR) with symptoms resolving a few hours later. Case reports indicate that the JHR can also include uterine contractions in pregnancy, worsening liver and renal function, acute respiratory distress syndrome, myocardial injury, hypotension, meningitis, alterations in consciousness, seizures, and strokes...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27956203/syphilis-during-pregnancy-a-preventable-threat-to-maternal-fetal-health
#2
REVIEW
Martha W F Rac, Paula A Revell, Catherine S Eppes
Syphilis remains the most common congenital infection worldwide and has tremendous consequences for the mother and her developing fetus if left untreated. Recently, there has been an increase in the number of congenital syphilis cases in the United States. Thus, recognition and appropriate treatment of reproductive-age women must be a priority. Testing should be performed at initiation of prenatal care and twice during the third trimester in high-risk patients. There are 2 diagnostic algorithms available and physicians should be aware of which algorithm is utilized by their testing laboratory...
December 9, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27859692/louse-borne-relapsing-fever-in-finland-in-two-asylum-seekers-from-somalia
#3
Jukka Hytönen, Tamim Khawaja, Juha O Grönroos, Anna Jalava, Seppo Meri, Jarmo Oksi
We report two cases of louse-borne relapsing fever (LBRF) in young Somali asylum seekers having recently arrived to Finland. They had sought medical attention for a febrile illness. Blood smears were examined for suspected malaria, but instead, spirochete shaped bacteria were observed. The bacteria were confirmed as Borrelia recurrentis by PCR and sequencing. The patients survived, but their treatment was complicated by Jarisch-Herxheimer reaction. We conclude that LBRF must be considered as a diagnostic option in febrile refugees also in the northernmost parts of Europe...
January 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27822621/-a%C3%A2-somali-refugee-with-fever-and-abnormal-blood-smear
#4
J Jochum, E Tannich, D Tappe, S Schmiedel
The increasing migration into Europe may confront clinicians with diseases barely known any more in this part of the world. We present a case of louse-borne relapsing fever in a Somali refugee. Blood smears led to the diagnosis of relapsing fever and DNA sequencing was positive for Borrelia recurrentis. This disease should be considered in all patients with unclear fever and a compatible travel or migration history. Blood smears are employed as the primary diagnostic method. Therapy harbors the danger of a Jarisch-Herxheimer reaction, a complication that may require intensive medical care...
November 7, 2016: Der Internist
https://www.readbyqxmd.com/read/27744340/clinical-characteristics-of-laboratory-confirmed-leptospirosis-in-okinawa-japan-1974-2015-high-incidence-of-jarisch-herxheimer-reaction
#5
Sanefumi Tsuha, Tomohiro Taniguchi, Soichi Shiiki, Masashi Narita, Daniel T Leung
BACKGROUND: Leptospirosis is a zoonotic disease known to have wide-ranging clinical manifestations. Despite a number of published case series, culture-confirmed series are few and there is a paucity of data on Jarisch-Herxheimer reaction (JHR) associated with treatment of leptospirosis. Our objective was to describe the clinical and epidemiological factors associated with leptospirosis in an endemic area of Japan, with a focus on the occurrence of JHR, an often unrecognized and likely underestimated phenomenon...
October 15, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27486653/andrew-herxheimer-medicine-for-the-people
#6
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Prescrire International
https://www.readbyqxmd.com/read/27483737/andrew-herxheimer-his-life-s-work-to-be-continued
#7
Danielle Bardelay, Gilles Bardelay
No abstract text is available yet for this article.
June 2016: Prescrire International
https://www.readbyqxmd.com/read/27440843/unique-expression-of-chronic-lyme-disease-and-jarisch-herxheimer-reaction-to-doxycycline-therapy-in-a-young-adult
#8
Chad Haney, Milap C Nahata
I am a 24-year-old male who was diagnosed with chronic Lyme disease after 4 years of multiple, non-specific symptoms. I have written this case as first author with my faculty mentor listed as the coauthor. The objective of this report is to highlight the experience with doxycycline treatment. In 2007, at around age 19 years, I had an acute onset of sore throat, tonsillitis, low-grade fever, stiff upper back and neck muscles, migraines and severely stiff, cracking jaw joints. This led to >24 medical visits, multitudes of tests and examinations, and exploratory surgery over the next 3 years...
July 20, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27116063/andrew-herxheimer
#9
Geoff Watts
No abstract text is available yet for this article.
April 16, 2016: Lancet
https://www.readbyqxmd.com/read/27031729/-candidatus-borrelia-kalaharica-detected-from-a-febrile-traveller-returning-to-germany-from-vacation-in-southern-africa
#10
Volker Fingerle, Michael Pritsch, Martin Wächtler, Gabriele Margos, Sabine Ruske, Jette Jung, Thomas Löscher, Clemens Wendtner, Andreas Wieser
A 26 year-old female patient presented to the Tropical Medicine outpatient unit of the Ludwig Maximilians-University in Munich with febrile illness after returning from Southern Africa, where she contracted a bite by a large mite-like arthropod, most likely a soft-tick. Spirochetes were detected in Giemsa stained blood smears and treatment was started with doxycycline for suspected tick-borne relapsing fever. The patient eventually recovered after developing a slight Jarisch-Herxheimer reaction during therapy...
March 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26967684/the-jarisch-herxheimer-reaction-and-brucellosis
#11
LETTER
Ângela Almeida, Paula Estanqueiro, Manuel Salgado
No abstract text is available yet for this article.
April 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26679971/effects-of-high-doses-of-vitamin-c-on-cancer-patients-in-singapore-nine-cases
#12
Yuen Chuen Fong Raymond, Chong Sze Ling Glenda, Lim Kah Meng
UNLABELLED: Introduction Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore. METHODS: The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined...
June 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/26568393/neurosyphilis-mimicking-ramsay-hunt-syndrome
#13
Tadashi Maeda, Sadako Yoshizawa, Takehisa Hirayama, Tomoo Saga, Kazuhiro Tateda, Yoshihisa Urita
A 36-year-old man presented with facial nerve palsy, hearing loss, vertigo and headache. He was initially diagnosed with Ramsay Hunt syndrome and treated with a systemic steroid and valaciclovir; however, his symptoms deteriorated. Serum rapid plasma reagin (RPR) and treponema pallidum hemagglutination tests were positive. Cerebrospinal fluid analysis revealed an elevated white blood cell count and positive RPR, confirming the diagnosis of neurosyphilis. Penicillin G (PCG) was administered, and his facial nerve function and headache improved...
2015: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/26521909/neurosyphilis-is-a-long-forgotten-disease-but-still-a-possible-etiology-for-dementia
#14
Hideharu Hagiya, Kentaro Deguchi, Kiyohiro Kawada, Fumio Otsuka
We herein report a heterosexual Japanese man in his forties who had been suffering from advanced dementia and personality change for 4 years. Positive results of a serological test for syphilis, Treponema pallidum hemagglutination assay, and fluorescent treponemal antibody-absorption test of both serum and cerebral spinal fluid led to the diagnosis of neurosyphilis. Jarisch-Herxheimer reaction was seen shortly after the first dose of penicillin was administered to the patient. His cognitive function did not recover after treatment...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26250069/louse-borne-relapsing-fever-borrelia-recurrentis-in-asylum-seekers-from-eritrea-the-netherlands-july-2015
#15
K R Wilting, Y Stienstra, B Sinha, M Braks, D Cornish, H Grundmann
Two patients from Eritrea, recently arrived in the Netherlands, presented with fever and were investigated for malaria. Bloodfilms showed spirochetes but no blood parasites. Louse-borne relapsing fever caused by Borrelia recurrentis was diagnosed. Treatment was complicated by severe Jarisch-Herxheimer reactions in both patients. Physicians should be aware of the possibility of B. recurrentis infection in migrant populations who travel under crowded conditions, especially after passing through endemic areas such as Ethiopia and neighbouring countries...
2015: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/26186104/azithromycin-is-equally-effective-as-amoxicillin-in-children-with-solitary-erythema-migrans
#16
Maja Arnež, Eva Ružić-Sabljić
BACKGROUND: Comparison of clinical efficacy and adverse effects of treatment with azithromycin and amoxicillin in children with solitary erythema migrans (EM). METHODS: Consecutive patients younger than 15 years with untreated solitary EM referred to our institution 2002-2003 were included in this unblinded prospective clinical study in which patients were alternatively treated with either azithromycin for 5 days or amoxicillin for 14 days. The efficacy of treatment of acute disease, development of minor and major manifestations of Lyme borreliosis and adverse effects of treatment were surveyed by follow-up visits during the first year after inclusion...
October 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26050305/-leptospirosis-in-a-family-after-whitewater-rafting-in-thailand
#17
C Gallardo, J Williams-Smith, K Jaton, S Asner, J-J Cheseaux, N Troillet, O Manuel, D Berthod
Leptospirosis is a zoonosis found worldwide, with an incidence that is approximately 10 times higher in the tropics than in temperate regions. The main reservoir of leptospirosis is the rat and human infection usually results from exposure to infected animal urine or tissues. Only 10% of cases are symptomatic. We present here two confirmed and two probable cases of leptospirosis in a family returning from whitewater rafting in Thailand, illustrating the wide variety of the clinical manifestations of this infection...
April 15, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/25868945/congenital-syphilis-presenting-as-jarisch-herxheimer-reaction-at-birth
#18
Hideyuki Hori, Yoshitake Sato, Tosiji Shitara
We report a rare case of congenital syphilis (CS) presenting as Jarisch-Herxheimer reaction (JHR) at birth. The mother (primigravida) presented in labor and had not received antenatal care. She was given prophylactic ampicillin 2 g i.v. on admission and delivered shortly thereafter. The male infant (2899 g) had normal vital signs, conjunctival congestion, splenohepatomegaly, and maculopapular rash with small blisters over the entire body. Serological tests on the infant and mother confirmed CS. The infant was given i...
April 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/25862773/leptospirosis-and-jarisch-herxheimer-reaction
#19
S Takamizawa, H Gomi, Y Shimizu, H Isono, T Shirokawa, M Kato
No abstract text is available yet for this article.
December 2015: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/25637233/-clinical-and-paraclinical-features-of-syphilitic-uveitis
#20
A-S Marty, P-L Cornut, H Janin-Manificat, L Perard, F Debats, C Burillon
INTRODUCTION: Syphilis, caused by Treponema pallidum agent, results in polymorphic and non-specific ocular manifestations. Early diagnosis and institution of individualized treatment play a large role in the prognosis. The increase in syphilis over the past several years requires the ophthalmologist to consider this diagnosis in the setting of any intraocular inflammatory involvement. PURPOSE: To describe epidemiological, clinical and paraclinical features and natural history of syphilitic uveitis...
March 2015: Journal Français D'ophtalmologie
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