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https://www.readbyqxmd.com/read/29775498/the-jarisch-herxheimer-reaction-in-syphilis-could-molecular-typing-help-to-understand-it-better
#1
M Arando, C Fernandez, M Mota-Foix, A Alvarez, P Armegol, M J Barberá, J Esperalba, M Vall-Mayans
OBJECTIVES: The Jarisch-Herxheimer reaction (JHR) is a febrile inflammatory reaction that may occur in patients after treatment of syphilis. The overall rate is estimated to be 10-25% with broad variations over time. It appears to be related to factors like stage of the disease or reagin titres. In this study we aimed to describe the incidence of and risk factors including strain typing for JHR among patients with syphilis. METHODS: From January through October 2015, 224 consecutive patients (82 of them with HIV) who were diagnosed with early syphilis were enrolled in this prospective observational study in a referral STI clinic in Barcelona...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29719831/a-30-year-old-man-with-hiv-fever-and-a-rash
#2
Radhika Shah, Saami Khalifian, Lyn Duncan, Daniela Kroshinsky, Bonnie Mackool
Patients who present with papular rashes have a wide differential diagnosis particularly in the setting of immune compromise. A 30-year-old male diagnosed with HIV since 2009, never on antiretroviral therapy, with a nadir CD4 count of 333 cells/mm3 and a current viral load of 44,300 copies/mL, presented with a diffuse monomorphic papular eruption that began on his trunk and extremities and subsequently spread to the penis and scrotum, sparing the distal acral sites. A thorough infectious workup revealed a positive rapid plasma reagin (RPR) and varicella IgM and IgG antibodies...
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29687066/acute-pustular-eruption-following-a-jarisch-herxheimer-reaction-in-the-treatment-of-syphilis
#3
Rachel L Giesey, Gregory R Delost, Timmie R Sharma, Kevin D Cooper
No abstract text is available yet for this article.
April 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29658212/tick-borne-relapsing-fever-with-severe-jarisch-herxheimer-reaction
#4
Yael Koton, Naiel Bisharat
No abstract text is available yet for this article.
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29333799/tick-borne-relapsing-fever-with-severe-jarisch-herxheimer-reaction
#5
Yael Koton, Naiel Bisharat
No abstract text is available yet for this article.
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29125076/-a-14-year-old-syrian-refugee-with-neurobrucellosis
#6
M S W Quaak, H H J Bavelaar, J Berkhout, G J Truin, E M Bijker
BACKGROUND: Neurobrucellosis is a rare complication of brucellosis, a bacterial zoonotic disease endemic in regions such as the Middle East. It is important to be alert for this imported disease in the Netherlands as well, especially among migrants. CASE DESCRIPTION: A 14-year-old boy from Syria presented with headache, vomiting and weight loss. Brucella melitensis was identified in the cerebrospinal fluid. The patient's condition deteriorated despite antibiotic treatment, particularly neurologically, and imaging revealed a newly developed hydrocephalus...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29076438/stevens-johnson-syndrome-versus-jarisch-herxheimer-reaction-in-an-hiv-positive-patient-with-secondary-syphilis
#7
Sarah Micozzi, Patricia Rojas Perez-Ezquerra, Cristina Morales-Cabeza, Cristina Diez, Manuel De Barrio
BACKGROUND: HIV positive patients can suffer many complications due to infectious diseases. A sever drug reaction to some of the drugs involved in the treatment can overlap the symptoms of the infections, making the diagnosis very difficult. We present the case of a 28-year-old-man, HIV positive, with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he received. The SJS was overlapped with a possible Jarisch Herxheimer Reaction, which complicated the diagnosis of the skin reaction...
2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29020150/a-multicenter-study-evaluating-ceftriaxone-and-benzathine-penicillin-g-as-treatment-agents-for-early-syphilis-in-jiangsu-china
#8
Yuping Cao, Xiaohong Su, Qianqiu Wang, Huazhong Xue, Xiaofeng Zhu, Chuanfu Zhang, Juan Jiang, Shuzhen Qi, Xiangdong Gong, Xiaofang Zhu, Min Pan, Hong Ren, Wenlong Hu, Zhiping Wei, Meihua Tian, Weida Liu
Background: The aim of this study was to assess the efficacy of ceftriaxone and benzathine penicillin G (BPG) in nonpregnant, immunocompetent adults with early syphilis because there is a lack of clinical evidence supporting ceftriaxone as an alternative treatment for early syphilis without an human immunodeficiency virus coinfection. Methods: A randomized, open-label controlled study evaluating the efficacy of ceftriaxone and BPG was conducted in 4 hospitals in Jiangsu Province...
October 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28942420/unique-manifestations-and-risk-factors-of-jarisch-herxheimer-reaction-during-treatment-of-child-congenital-syphilis
#9
Caiying Wang, Shuxin He, Hongling Yang, Yuhuan Liu, Yang Zhao, Lin Pang
OBJECTIVES: The objective of this retrospective study was to summarise the clinical manifestations of, and to analyse the incidence and risk factors of, Jarisch-Herxheimer reaction (JHR) during the treatment of children with symptomatic congenital syphilis. METHODS: Clinical data of 60 children with clinically and laboratory diagnosed congenital syphilis, hospitalised in Beijing Ditan Hospital between January 2010 and November 2015, were collected and analysed. RESULTS: A total of 11 patients with congenital syphilis (11/60, 18...
September 23, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28527874/pressor-support-during-a-jarisch-herxheimer-reaction-after-initiation-of-treatment-for-weil-s-disease
#10
Randi Connor-Schuler, Anee Khan, Nikhil Goyal, Erin Zimny
We present a case of Weil's disease complicated by a Jarisch-Herxheimer reaction (JHR) after initiation of antibiotics while in the emergency department requiring invasive monitoring and vasopressor support. The case is followed by a brief review of the JHR which is rarely observed with treatment of leptospirosis. A healthy 28-year-old female who recently returned from the Caribbean presented to the emergency department with flu-like symptoms. The patient appeared jaundiced with conjunctival suffusion and was ultimately treated with the appropriate antibiotics for leptospirosis in the ED...
August 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28414665/a-case-of-early-neurosyphilis
#11
M Walker, R Wisler, J Simmons, A Johnson
INTRODUCTION: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis. CASE: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28393665/the-first-report-of-bartonella-quintana-immune-reconstitution-inflammatory-syndrome-complicated-by-jarisch-herxheimer-reaction
#12
Michelle DallaPiazza, Matthew Jiro Akiyama
Bacillary angiomatosis (BA) is a rare complication of human immune deficiency virus (HIV) infection in the post-antiretroviral therapy (ART) era, and few cases of BA-associated immune reconstitution inflammatory syndrome (IRIS) have been described. We report the case of a 50-year-old man who presented with mass lesions involving the skin, subcutaneous tissues, muscle, and bone. The diagnosis of Bartonella quintana BA was confirmed by serum polymerase chain reaction. The patient's treatment course was complicated by both IRIS and Jarisch-Herxheimer reaction...
July 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28181892/-fever-and-hypotension-after-treatment-of-syphilis-the-jarisch-herxheimer-reaction
#13
K D Hendriks, R W van Etten, P van Wijngaarden
A 73-year-old man presented with fever and hypotension, which had developed a few hours after receiving treatment with benzyl-penicillin for secondary syphilis. These symptoms were due to the so-called Jarisch-Herxheimer reaction. The patient was admitted to hospital and treated with prednisone and intravenous fluids. Within 24 hours the patient had fully recovered. The symptoms, pathogenesis and treatment of Jarisch-Herxheimer reaction are discussed.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28127144/a-nodular-ulcerative-form-of-secondary-syphilis-in-aids
#14
Ofelya Gevorgyan, Benjamin D Owen, Arvind Balavenkataraman, Mitchell R Weinstein
An uncommon variant in the pre-AIDS era, lues maligna is a nodular-ulcerative form of secondary syphilis. We present a case of a 41-year-old man with HIV infection who developed fever, chills, nausea, vomiting, right upper quadrant abdominal pain, weight loss, watery diarrhea, and a painless, nonpruritic rash. He had diffuse nodular-ulcerative lesions in various stages of development. He was found to have a CD4 count of 101 cells/mm(3) (22%), an HIV viral load of 2,735,060 copies/mL, and a positive rapid plasma reagin at 1:64...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28115662/jarisch-herxheimer-reaction-among-patients-with-leptospirosis-incidence-and-risk-factors
#15
Gilles Guerrier, Patrick Lefèvre, Chantal Chouvin, Eric D'Ortenzio
AbstractA Jarisch-Herxheimer reaction (JHR) may be precipitated after initiation of chemotherapy in spirochetal diseases, including leptospirosis. However, a clear idea of the importance of JHR in this disease is lacking. The incidence of and risk factors for JHR were investigated retrospectively among 262 patients with confirmed leptospirosis who received amoxicillin treatment in New Caledonia and Futuna. The overall rate of JHR was 21% (12% in New Caledonia and 44% in Futuna). Two risk factors were independently associated with JHR occurrence: Leptospira interrogans serogroup Australis as the infecting strain (odds ratio [OR] = 2...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28077740/the-jarisch-herxheimer-reaction-after-antibiotic-treatment-of-spirochetal-infections-a-review-of-recent-cases-and-our-understanding-of-pathogenesis
#16
REVIEW
Thomas Butler
Within 24 hours after antibiotic treatment of the spirochetal infections syphilis, Lyme disease, leptospirosis, and relapsing fever (RF), patients experience shaking chills, a rise in temperature, and intensification of skin rashes known as the Jarisch-Herxheimer reaction (JHR) with symptoms resolving a few hours later. Case reports indicate that the JHR can also include uterine contractions in pregnancy, worsening liver and renal function, acute respiratory distress syndrome, myocardial injury, hypotension, meningitis, alterations in consciousness, seizures, and strokes...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27956203/syphilis-during-pregnancy-a-preventable-threat-to-maternal-fetal-health
#17
REVIEW
Martha W F Rac, Paula A Revell, Catherine S Eppes
Syphilis remains the most common congenital infection worldwide and has tremendous consequences for the mother and her developing fetus if left untreated. Recently, there has been an increase in the number of congenital syphilis cases in the United States. Thus, recognition and appropriate treatment of reproductive-age women must be a priority. Testing should be performed at initiation of prenatal care and twice during the third trimester in high-risk patients. There are 2 diagnostic algorithms available and physicians should be aware of which algorithm is utilized by their testing laboratory...
April 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27859692/louse-borne-relapsing-fever-in-finland-in-two-asylum-seekers-from-somalia
#18
Jukka Hytönen, Tamim Khawaja, Juha O Grönroos, Anna Jalava, Seppo Meri, Jarmo Oksi
We report two cases of louse-borne relapsing fever (LBRF) in young Somali asylum seekers having recently arrived to Finland. They had sought medical attention for a febrile illness. Blood smears were examined for suspected malaria, but instead, spirochete shaped bacteria were observed. The bacteria were confirmed as Borrelia recurrentis by PCR and sequencing. The patients survived, but their treatment was complicated by Jarisch-Herxheimer reaction. We conclude that LBRF must be considered as a diagnostic option in febrile refugees also in the northernmost parts of Europe...
January 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27822621/-a-somali-refugee-with-fever-and-abnormal-blood-smear
#19
J Jochum, E Tannich, D Tappe, S Schmiedel
The increasing migration into Europe may confront clinicians with diseases barely known any more in this part of the world. We present a case of louse-borne relapsing fever in a Somali refugee. Blood smears led to the diagnosis of relapsing fever and DNA sequencing was positive for Borrelia recurrentis. This disease should be considered in all patients with unclear fever and a compatible travel or migration history. Blood smears are employed as the primary diagnostic method. Therapy harbors the danger of a Jarisch-Herxheimer reaction, a complication that may require intensive medical care...
March 2017: Der Internist
https://www.readbyqxmd.com/read/27744340/clinical-characteristics-of-laboratory-confirmed-leptospirosis-in-okinawa-japan-1974-2015-high-incidence-of-jarisch-herxheimer-reaction
#20
Sanefumi Tsuha, Tomohiro Taniguchi, Soichi Shiiki, Masashi Narita, Daniel T Leung
BACKGROUND: Leptospirosis is a zoonotic disease known to have wide-ranging clinical manifestations. Despite a number of published case series, culture-confirmed series are few and there is a paucity of data on Jarisch-Herxheimer reaction (JHR) associated with treatment of leptospirosis. Our objective was to describe the clinical and epidemiological factors associated with leptospirosis in an endemic area of Japan, with a focus on the occurrence of JHR, an often unrecognized and likely underestimated phenomenon...
September 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
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