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Chlamydia pneumoniae

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https://www.readbyqxmd.com/read/28330238/isolation-of-antimicrobial-resistant-bacteria-in-upper-respiratory-tract-infections-of-patients
#1
Li-Min Wang, Xiao-Liang Qiao, Liang Ai, Jing-Jing Zhai, Xue-Xia Wang
Haemophilus influenzae, Streptococcus pyogenes, Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pneumoniae are usual cause of upper respiratory tract infection cases. The present study aims the isolation of bacterial strains which are resistant to the commonly prescribed antibiotics. In total, 900 throat swabs were obtained from the patients suffering from upper respiratory tract infections residing in three different localities. The maximum number of isolates (64 %) were obtained from locality-1 (L-1), whereas lowest isolates were found in second locality (L-2)...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28277149/in-vitro-activity-of-a-partially-purified-and-characterized-bark-extract-of-castanea-sativa-mill-enc%C3%A2-against-chlamydia-spp
#2
Valentina Papa, Laura Ginocchietti, Roberta Budriesi, Matteo Micucci, Roberta Costa, Roberta Biondi, Roberto Cevenini, Alberto Chiarini, Rita Aldini, Manuela Donati, Gian Matteo Pollini, Giovanna Cenacchi
Castanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae. The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C...
March 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28264910/the-expanding-role-of-type-ii-secretion-in-bacterial-pathogenesis-and-beyond
#3
Nicholas P Cianciotto, Richard C White
Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria, occurring in many, but not all genera in the α-, β-, γ-, and δ- classes. Prominent human and/or animal pathogens that express a T2S system(s) include Acinetobacter baumannii, Burkholderia pseudomallei, Chlamydia trachomatis, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Vibrio cholerae, and Yersinia enterocolitica T2S-expressing plant pathogens include Dickeya dadantii, Erwinia amylovora, Pectobacterium carotovorum, Ralstonia solanacearum, Xanthomonas campestris, Xanthomonas oryzae, and Xylella fastidiosa T2S also occurs in non-pathogenic bacteria, facilitating symbioses, among other things...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28251179/fluorocycline-tp-271-is-potent-against-complicated-community-acquired-bacterial-pneumonia-pathogens
#4
Trudy H Grossman, Corey Fyfe, William O'Brien, Meredith Hackel, Mary Beth Minyard, Ken B Waites, Jacques Dubois, Timothy M Murphy, Andrew M Slee, William J Weiss, Joyce A Sutcliffe
TP-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. TP-271 was active in MIC assays against key community respiratory Gram-positive and Gram-negative pathogens, including Streptococcus pneumoniae (MIC90 = 0.03 µg/ml), methicillin-sensitive Staphylococcus aureus (MSSA; MIC90 = 0.25 µg/ml), methicillin-resistant S. aureus (MRSA; MIC90 = 0.12 µg/ml), Streptococcus pyogenes (MIC90 = 0...
January 2017: MSphere
https://www.readbyqxmd.com/read/28182619/contribution-of-common-infections-to-cardiovascular-risk-in-hiv-positive-individuals
#5
Victoria Berquist, Jennifer F Hoy, Janine M Trevillyan
HIV-positive individuals are at increased risk for cardiovascular disease due to complex interactions between the increased incidence of traditional cardiovascular risk factors and HIV and antiretroviral-associated inflammation and dyslipidemia. Increasing evidence suggests that a number of important co-pathogens, including cytomegalovirus, hepatitis C virus, and periodontal disease, are likely to also be contributing. Mechanisms such as molecular mimicry and modification of lipids play a role; however, induction of systemic inflammation is the likely key pathogenic link by which this occurs...
February 9, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28158541/cholesterol-uptake-in-the-mouse-aorta-increases-during-chlamydia-pneumoniae-infection
#6
Marie Edvinsson, Jonas Tallkvist, Christina Nyström-Rosander, Nils-Gunnar Ilbäck
No abstract text is available yet for this article.
February 2, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28129377/high-prevalence-of-mycoplasma-pneumoniae-and-chlamydia-pneumoniae-in-children-with-acute-respiratory-infections-from-lima-peru
#7
Juana Del Valle-Mendoza, Fiorella Orellana-Peralta, Alvaro Marcelo-Rodríguez, Eduardo Verne, Mónica Esquivel-Vizcarra, Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Pablo Weilg, Verónica Casabona-Oré, Claudia Ugarte, Luis J Del Valle
BACKGROUND: Mycoplasma pneumoniae and Chlamydia pneumoniae are atypical pathogens responsible for pneumonia and a leading cause of morbidity and mortality in low income countries. The study objective is to determine the prevalence of this pathogens in Peruvian children with acute respiratory infections. METHODS: A consecutive cross-sectional study was conducted in Lima, Peru from May 2009 to September 2010. A total of 675 children admitted with clinical diagnoses of acute respiratory infections were tested for Mycoplasma pneumoniae and Chlamydia pneumoniae detection by polymerase chain reaction (PCR), and clinical symptoms were registered by the attending physician...
2017: PloS One
https://www.readbyqxmd.com/read/28120588/the-association-of-chlamydia-pneumonia-and-helicobacter-pylori-igg-seropositivity-with-omentin-1-visfatin-and-adiponectin-levels-in-postmenopausal-women
#8
Reza Ranjbar, Alireza Bolkheir, Katayoun Vahdat, Majid Assadi, Hossein Darabi, Iraj Nabipour
Some adipocytokines are cardioprotective or pro-inflammatory for cardiovascular system. Chronic infection with Chlamydia pneumoniae and Helicobacter pylori has been also considered as novel risk factors for atherosclerosis. The main aim of the current population-based study is to investigate the potential link between circulating adipocytokines and Chlamydia pneumoniae or Helicobacter pylori IgG seropositivities. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C...
December 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28102626/neonatal-apnea-with-chlamydia-pneumoniae-infection
#9
Yuta Sasaoka, Yuko Yoto, Masatoshi Tatsumi, Kazuki Iida, Hiroyuki Tsutsumi
No abstract text is available yet for this article.
January 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28087650/simkania-negevensis-may-produce-long-lasting-infections-in-human-pneumocytes-and-endometrial-cells
#10
Manon Vouga, David Baud, Gilbert Greub
Simkania negevensis is a novel Chlamydia-related bacterium and the founding member of the Simkaniaceae family within the Chlamydiales order. Little is known about the biology and pathogenesis of this bacterium. So far, S. negevensis has been considered as an amoebal symbiont, but its natural host remains unknown. Moreover, evidence of human exposition has been reported worldwide and an association with pneumonia and bronchiolitis is suspected. Here, we evaluated the ability of S. negevensis to replicate in potential environmental reservoirs, namely amoebae and arthropods, as well as in mammalian cells (Vero cells, pneumocytes and endometrial cells) and further evaluated the characteristics of its replicative vacuole...
January 12, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28051279/carotid-intima-media-thickness-and-blood-biomarkers-of-atherosclerosis-in-patients-after-stroke-or-myocardial-infarction
#11
Iwona Kurkowska-Jastrzebska, Michał A Karlinski, Beata Błazejewska-Hyzorek, Iwona Sarzynska-Dlugosz, Krzysztof J Filipiak, Anna Czlonkowska
AIM: To test if circulating levels of markers of inflammation, endothelial function, and chronic infections, as well as association between these markers and carotid intima media thickness (CIMT), depend on the stage of atherosclerosis expressed as a history of a major vascular event. METHODS: The associations were analyzed separately in 75 healthy controls, 79 patients 3-6 months after the first-ever non-cardioembolic ischemic stroke (IS), and 37 patients 3-6 months after the first-ever myocardial infarction (MI)...
December 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/28035483/chlamydia-pneumoniae-induces-interleukin-12-responses-in-peripheral-blood-mononuclear-cells-in-asthma-and-the-role-of-toll-like-receptor-2-versus-4-a-pilot-study
#12
T A Smith-Norowitz, J Perlman, Y M Norowitz, R Joks, H G Durkin, M R Hammerschlag, S Kohlhoff
BACKGROUND: Chlamydia pneumoniae causes respiratory infection in adults and children, and has been associated with asthma exacerbations and induction of Immunoglobulin (Ig) E responses. We previously reported that C. pneumoniae enhances T helper (Th) 2 responses of peripheral blood mononuclear cells (PBMC) from asthmatic patients. It is likely that toll like receptor (TLR)-2 and TLR-4 mediate cytokine responses and host defense against C. pneumoniae. Thus, we sought to determine whether engagement of TLR-2 or TLR-4 may induce IL-12 production in our C...
December 29, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28032346/mannose-binding-lectin-and-l-ficolin-polymorphisms-in-patients-with-community-acquired-pneumonia-caused-by-intracellular-pathogens
#13
Gijs van Kempen, Sabine Meijvis, Hendrik Endeman, Bart Vlaminckx, Bob Meek, Ben de Jong, Ger T Rijkers, Willem Jan Bos
Community acquired pneumonia (CAP) is the leading infectious disease requiring hospitalisation in the Western World. Genetic variability affecting the host response to infection may play a role in susceptibility and outcome in CAP patients. Mannose binding lectin (MBL) and L-ficolin (L-FCN) are two important activators of the complement system and they can enhance phagocytosis by opsonisation. In a prospective cohort of 505 Dutch CAP patients and 227 controls we studied whether polymorphisms in the MBL (MBL2) and FCN (FCN2) genes influenced susceptibility and outcome...
December 29, 2016: Immunology
https://www.readbyqxmd.com/read/27978822/acanthamoeba-containing-endosymbiotic-chlamydia-isolated-from-hospital-environments-and-its-potential-role-in-inflammatory-exacerbation
#14
Tatsuya Fukumoto, Junji Matsuo, Torahiko Okubo, Shinji Nakamura, Kentaro Miyamoto, Kentaro Oka, Motomichi Takahashi, Kouji Akizawa, Hitoshi Shibuya, Chikara Shimizu, Hiroyuki Yamaguchi
BACKGROUND: Environmental chlamydiae belonging to the Parachlamydiaceae are obligate intracellular bacteria that infect Acanthamoeba, a free-living amoeba, and are a risk for hospital-acquired pneumonia. However, whether amoebae harboring environmental chlamydiae actually survive in hospital environments is unknown. We therefore isolated living amoebae with symbiotic chlamydiae from hospital environments. RESULTS: One hundred smear samples were collected from Hokkaido University Hospital, Sapporo, Japan; 50 in winter (February to March, 2012) and 50 in summer (August, 2012), and used for the study...
December 15, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27960206/role-of-atypical-pathogens-in-the-etiology-of-community-acquired-pneumonia
#15
Forest W Arnold, James T Summersgill, Julio A Ramirez
Atypical pneumonia has been described for over 100 years, but some of the pathogens attributed to it have been identified only in the past decades. The most common pathogens are Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila. The epidemiology and pathophysiology of these three pathogens have been studied since their discovery, and are reviewed herein to provide better insight when evaluating these patients, which hopefully translates into improved care. The incidence of atypical pathogens has been shown to be approximately 22% worldwide, but this probably varies with location...
December 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27940015/atypical-chlamydia-psittaci-pneumonia-four-related-cases
#16
Nuria Arenas-Valls, Silvia Chacón, Alfredo Pérez, Roberto Del Pozo
No abstract text is available yet for this article.
December 7, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27939160/chlamydial-infections-in-wildlife-conservation-threats-and-or-reservoirs-of-spill-over-infections
#17
REVIEW
Delaney Burnard, Adam Polkinghorne
Members of the order Chlamydiales are biphasic intracellular pathogens known to cause disease in both humans and animals. As we learn more about the genetic diversity of this group of pathogens, evidence is growing that these bacteria infect a broader range of animal hosts than previously thought. Over 400 host species are now documented globally with the majority of these being wild animals. Given the impact of chlamydial infections on humans and domesticated animals, the identification of members of the order Chlamydiales in wildlife raises significant questions over a) their impact on animal health and b) the relationships to those strains also found in humans and domestic animals...
November 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27935539/role-of-chlamydia-pneumoniae-in-the-pathogenesis-of-hypertrophy-and-adenoid-tissue-inflammation-in-children
#18
Anna Bielicka, Beata Zielnik-Jurkiewicz, Edyta Podsiadły, Monika Prochorec-Sobieszek, Joanna Rogulska, Urszula Demkow
OBJECTIVE: A tropism to epithelial cells and lymphocytes, an inhibition of apoptosis in host cells, an ability to occurrence in persistent form resistant to antibiotic treatment are the features of Chlamydia pneumoniae, which can have connection with chronic inflammation of an adenoid tissue and adenoid hypertrophy. This study aimed to (1) detect the C. pneumoniae in an adenoid in children undergoing adenoidectomy, (2) estimate a connection between C. pneumoniae occurrence and the size of adenoid, (3) demonstration in which of adenoid cells C...
October 31, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/27916800/lead-discovery-strategies-for-identification-of-chlamydia-pneumoniae-inhibitors
#19
REVIEW
Leena Hanski, Pia Vuorela
Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. In this review, we describe the strategies that have been successfully applied for the identification of nonconventional antichlamydial agents, including target-based and ligand-based virtual screening, ethnopharmacological approach and pharmacophore-based design of antimicrobial peptide-mimicking compounds...
November 28, 2016: Microorganisms
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#20
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
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