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Chlamydia pneumoniae

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https://www.readbyqxmd.com/read/28913776/interactions-of-antisera-to-different-chlamydia-and-chlamydophila-species-with-the-ribosomal-protein-rps27a-correlate-with-impaired-protein-synthesis-in-a-human-choroid-plexus-papilloma-cell-line
#1
Abdullah Almamy, Christian Schwerk, Horst Schroten, Hiroshi Ishikawa, Abdul Rahman Asif, Bernhard Reuss
Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a...
September 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28903431/detection-of-specific-chlamydia-pneumoniae-and-cytomegalovirus-antigens-in-human-carotid-atherosclerotic-plaque-in-a-chinese-population
#2
Jiachao Cao, Yumin Mao, Bo Dong, Wei Guan, Jia Shi, Suinuan Wang
To explore the relationship between certain pathogens, such as chlamydia pneumonia (Cpn) and cytomegalovirus (CMV), and carotid atherosclerosis (AS) in a Chinese population.Twenty-five carotid atherosclerotic stenosis patients from the Beijing Tiantan Hospital (affiliated with Capital Medical University) participated in the study. After undergoing digital subtraction angiography (DSA) and/or computed tomography angiography (CTA), the degree of carotid artery stenosis was over 70% in all cases, and the patients underwent carotid endarterectomy...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900526/lung-us-features-of-severe-interstitial-pneumonia-case-report-and-review-of-the-literature
#3
Tiziano Perrone, Federica Quaglia
BACKGROUND: Chlamydia pneumonia is reported to account for a relatively large number of cases of CAP. In elderly patients in particular, the clinical presentation can be a severe form of diffuse interstitial pneumonia. The chest X-ray presentation is aspecific. Lung US can show a typical pattern of diffuse interstitial lung syndrome; in some cases, like the present one, the association of multiple B lines with a coarse and thickened pleural line points to a more likely diagnosis of interstitial pneumonia...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#4
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28891690/compendium-of-measures-to-control-chlamydia-psittaci-infection-among-humans-psittacosis-and-pet-birds-avian-chlamydiosis-2017
#5
Gary Balsamo, Angela M Maxted, Joanne W Midla, Julia M Murphy, Ron Wohrle, Thomas M Edling, Pilar H Fish, Keven Flammer, Denise Hyde, Preeta K Kutty, Miwako Kobayashi, Bettina Helm, Brit Oiulfstad, Branson W Ritchie, Mary Grace Stobierski, Karen Ehnert, Thomas N Tully
Psittacosis, also known as parrot fever and ornithosis, is a bacterial infection that can cause severe pneumonia and other serious health problems in humans. It is caused by Chlamydia psittaci. Reclassification of the order Chlamydiales in 1999 into 2 genera (Chlamydia and Chlamydophila) was not wholly accepted or adopted. This resulted in a reversion to the single, original genus Chlamydia, which now encompasses all 9 species including Chlamydia psittaci. During 2003-2014, 112 human cases of psittacosis were reported to the Centers for Disease Control and Prevention through the Nationally Notifiable Diseases Surveillance System...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28879822/the-impact-of-pathogen-burden-on-leukocyte-telomere-length-in-the-multi-ethnic-study-of-atherosclerosis
#6
A E Aiello, B Jayabalasingham, A M Simanek, A Diez-Roux, L Feinstein, H C S Meier, B L Needham, J B Dowd
Several infections have been linked to telomere shortening and in some cases these associations have varied by sex. We assessed the association between seropositivity to four persistent pathogens (cytomegalovirus (CMV), herpes simplex virus-1, Helicobacter pylori, Chlamydia pneumoniae), and total pathogen burden on leukocyte telomere length in a diverse US sample. Data came from the Multi-Ethnic Study of Atherosclerosis, a population-based cohort study. We utilized cross-sectional survey data, and biological samples from participants tested for pathogens and telomere length (N = 163)...
September 7, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28877022/zoonotic-chlamydia-caviae-presenting-as-community-acquired-pneumonia
#7
LETTER
Bart P Ramakers, Marloes Heijne, Natascha Lie, Thuy-Nga Le, Monique van Vliet, Vivian P J Claessen, Paulien J P Tolsma, Mauro De Rosa, Hendrik I J Roest, Daisy Vanrompay, Edou R Heddema, Peter Schneeberger, Mirjam H A Hermans
New England Journal of Medicine, Volume 377, Issue 10, Page 992-994, September 2017.
September 7, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28869155/investigation-of-chlamydia-pneumoniae-infection-in-moroccan-patients-suffering-from-cardiovascular-diseases
#8
Loubna El Yazouli, Hicham Hejaji, Naima Elmdaghri, Aziz Aroussi Alami, Nadia Dakka, Fouzia Radouani
Chlamydia pneumoniae is an intracellular bacterium responsible for respiratory diseases and is highly involved in cardiovascular disease development, mainly atherosclerosis. The main objective of our study was to evaluate C. pneumoniae prevalence in Moroccan patients suffering from cardiovascular diseases. A total of 115 patients with cardiovascular diseases were enrolled, and their clinical and behavioral information was recorded. Blood was sampled from all patients as well as the atheroma plaques from 36 patients undergoing surgery...
August 28, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28867456/antimicrobial-activity-of-bitespiramycin-a-new-genetically-engineered-macrolide
#9
Weiqing He, Chunping Yang, Xiaofeng Zhao, Yiguang Wang
The antimicrobial activity of bitespiramycin (BT) against Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cp), Ureaplasma urealyticum (Uu), and Mycoplasma pneumoniae (Mp), was compared with those of azithromycin (AZM) and acetylspiramycin (AT-SP) in vitro. Furthermore, the anti-Mp activities of BT and AZM were evaluated in a hamster model. The activities of BT in vitro were similar to those of AZM but were more effective than those of AT-SP. BT effectively inhibited Mp infection at a dose of 200mg/kg in a hamster model...
August 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28768558/chlamydia-gallinacea-a-widespread-emerging-chlamydia-agent-with-zoonotic-potential-in-backyard-poultry
#10
L Li, M Luther, K Macklin, D Pugh, J Li, J Zhang, J Roberts, B Kaltenboeck, C Wang
Chlamydia gallinacea, a new chlamydial agent, has been reported in four European countries as well as Argentina and China. Experimentally infected chickens with C. gallinacea in previous study showed no clinical signs but had significantly reduced gains in body weight (6·5-11·4%). Slaughterhouse workers exposed to infected chickens have developed atypical pneumonia, indicating C. gallinacea is likely a zoonotic agent. In this study, FRET-PCR confirmed that C. gallinacea was present in 12·4% (66/531) of oral-pharyngeal samples from Alabama backyard poultry...
August 3, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28746046/detection-of-specific-chlamydia-pneumoniae-and-cytomegalovirus-antigens-in-human-carotid-atherosclerotic-plaque-in-a-chinese-population
#11
Jiachao Cao, Yumin Mao, Bo Dong, Wei Guan, Jia Shi, Suinuan Wang
To explore the relationship between certain pathogens, such as chlamydia pneumonia (Cpn) and cytomegalovirus (CMV), and carotid atherosclerosis (AS) in a Chinese population.Twenty-five carotid atherosclerotic stenosis patients from the Beijing Tiantan Hospital (affiliated with Capital Medical University) participated in the study. After undergoing digital subtraction angiography (DSA) and/or computed tomography angiography (CTA), the degree of carotid artery stenosis was over 70% in all cases, and the patients underwent carotid endarterectomy...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722366/-large-vessel-vasculitis-pathogenesis-diagnostic-and-medical-management
#12
Alireza Sadrkhah, Jörg D Seebach, Yannick Muller
Large vessels vasculitis includes two diseases : 1) giant cell arteritis, formerly known as Horton's arteritis and 2) Takayasu arteritis. In this article, we will describe and compare the epidemiology, pathogenesis, diagnostic criteria and medical management of both vasculitis. T helper (Th) 1 and Th17 responses, genetic links and the role of viral (varicella zoster) and bacterial infection (Mycoplasma pneumoniae or Chlamydia pneumoniae) will be discussed. Classification criteria, inflammation biomarkers and progress in imaging tools will also be described...
April 5, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28693414/hypothetical-protein-cpn0423-triggers-nod2-activation-and-contributes-to-chlamydia-pneumoniae-mediated-inflammation
#13
Hong-Liang Chen, Guo-Zhi Dai, An-Wen Zhou, Ran-Hui Li, Hong-Xia Yuan, Jing Xiang, Xiao-Xing You, Ou Ran, Yi-Mou Wu
BACKGROUND: Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linking C. pneumoniae components to inflammation remain elusive. This study was to investigate the effect of Chlamydia-specific Cpn0423 of C. pneumoniae on C. pneumoniae-mediated inflammation. RESULTS: Cpn0423 was detected outside of C. pneumoniae inclusions, which induced production of several cytokines including macrophage inflammatory protein-2 (MIP-2) and interleukins (ILs)...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28691023/iron-homeostasis-in-tissues-is-affected-during-persistent-chlamydia-pneumoniae-infection-in-mice
#14
Marie Edvinsson, Jonas Tallkvist, Christina Nyström-Rosander, Nils-Gunnar Ilbäck
Chlamydia pneumoniae (C. pneumoniae) may be a mediator in the pathogenesis of atherosclerosis. For its growth C. pneumoniae depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. C. pneumoniae-infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40. Mice had bacteria in the lungs and liver on all days. Inflammatory markers, chemokine Cxcl2 and interferon-gamma, were not affected in the liver on day 40. The copper (Cu)/zinc (Zn) ratio in serum, another marker of infection/inflammation, increased on day 4 and tended to increase again on day 40...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28680713/robust-immunoreactivity-of-teenager-sera-against-peptide-19-from-porphyromonas-gingivalis-hsp60
#15
Eun-Young Kwon, Gil Sun Cha, Ji-Young Joo, Ju-Youn Lee, Jeomil Choi
PURPOSE: Epitope spreading is a phenomenon in which distinct subdominant epitopes become major targets of the immune response. Heat shock protein (HSP) 60 from Porphyromonas gingivalis (PgHSP60) and peptide 19 from PgHSP60 (Pep19) are immunodominant epitopes in autoimmune disease patients, including those with periodontitis. It remains unclear whether Pep19 is a dominant epitope in subjects without periodontitis or autoimmune disease. The purpose of this study was to determine the epitope spreading pattern and verify Pep19 as an immunodominant epitope in healthy teenagers using dot immunoblot analysis...
June 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28638138/immune-regulation-by-oral-tolerance-induces-alternate-activation-of-macrophages-and-reduces-markers-of-plaque-destabilization-in-apob-tm2sgy-ldlr-tm1her-j-mice
#16
Lakshmi Narasimha Thota, Thiruvelselvan Ponnusamy, Sheena Philip, Xinjie Lu, Lakshmi Mundkur
Atherosclerosis is the leading cause for cardiovascular mortality. We determined the effect of multi-antigenic construct expressing three peptides AHC (ApoB100, HSP60 and outer membrane protein of chlamydia pneumonia) in stabilizing advanced atherosclerosis in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice. Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks. Tolerance was associated with significantly higher numbers of regulatory T cells both in aortic sinus and spleen with higher mRNA expression of CTLA4 (3 fold), Foxp3 (1...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628024/-evaluation-of-dynamic-telomere-length-shortening-of-lymphocytes-in-immunocompromised-children-with-chronic-diseases-of-the-respiratory
#17
E Khalturina, I Nesterova
Nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (DL), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. The conducted study has shown the shortening of telomere lymphocytes in children with CDRT seropositive for mixed-herpes viral infections (herpes simplex virus, virus, Epstein-Barr virus and cytomegalovirus in various combinations) and for bacterial co-infections - Chlamydia trachomatis and (or) Mycoplasma pneumoniae...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28604836/elevated-sodium-leads-to-the-increased-expression-of-hsp60-and-induces-apoptosis-in-huvecs
#18
Bojana Jakic, Maja Buszko, Giuseppe Cappellano, Georg Wick
Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products)...
2017: PloS One
https://www.readbyqxmd.com/read/28600769/methods-for-real-time-pcr-based-diagnosis-of-chlamydia-pneumoniae-chlamydia-psittaci-and-chlamydia-abortus-infections-in-an-opened-molecular-diagnostic-platform
#19
Onya Opota, René Brouillet, Gilbert Greub, Katia Jaton
The advances in molecular biology of the last decades have dramatically improved the field of diagnostic bacteriology. In particular, PCR-based technologies have impacted the diagnosis of infections caused by obligate intracellular bacteria such as pathogens from the Chlamydiacae family. Here, we describe a real-time PCR-based method using the Taqman technology for the diagnosis of Chlamydia pneumoniae, Chlamydia psittaci, and Chlamydia abortus infection. The method presented here can be applied to various clinical samples and can be adapted on opened molecular diagnostic platforms...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28577241/human-infectious-diseases-and-risk-of-preeclampsia-an-updated-review-of-the-literature
#20
REVIEW
Malihe Nourollahpour Shiadeh, Zahra Behboodi Moghadam, Ishag Adam, Vafa Saber, Maryam Bagheri, Ali Rostami
BACKGROUND: Preeclampsia (PE) is one of the major causes of maternal and perinatal morbidity and mortality, especially in low- and middle-income countries. In recent years, a growing body of literatures suggests that infections by bacteria, viruses, and parasites and their related inflammations play an important role in the pathogenesis of PE. METHODS: We searched PubMed, Google scholar, and Cochrane databases using the following search words: "infection and preeclampsia," "bacterial infection and preeclampsia," "viral infection and preeclampsia" and "parasitic infection and preeclampsia...
June 2, 2017: Infection
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