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Chlamydia pneumoniae

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https://www.readbyqxmd.com/read/28638138/immune-regulation-by-oral-tolerance-induces-alternate-activation-of-macrophages-and-reduces-markers-of-plaque-destabilization-in-apob-tm2sgy-ldlr-tm1her-j-mice
#1
Lakshmi Narasimha Thota, Thiruvelselvan Ponnusamy, Sheena Philip, Xinjie Lu, Lakshmi Mundkur
Atherosclerosis is the leading cause for cardiovascular mortality. We determined the effect of multi-antigenic construct expressing three peptides AHC (ApoB100, HSP60 and outer membrane protein of chlamydia pneumonia) in stabilizing advanced atherosclerosis in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice. Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks. Tolerance was associated with significantly higher numbers of regulatory T cells both in aortic sinus and spleen with higher mRNA expression of CTLA4 (3 fold), Foxp3 (1...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28628024/-evaluation-of-dynamic-telomere-length-shortening-of-lymphocytes-in-immunocompromised-children-with-chronic-diseases-of-the-respiratory
#2
E Khalturina, I Nesterova
Nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (DL), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. The conducted study has shown the shortening of telomere lymphocytes in children with CDRT seropositive for mixed-herpes viral infections (herpes simplex virus, virus, Epstein-Barr virus and cytomegalovirus in various combinations) and for bacterial co-infections - Chlamydia trachomatis and (or) Mycoplasma pneumoniae...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28604836/elevated-sodium-leads-to-the-increased-expression-of-hsp60-and-induces-apoptosis-in-huvecs
#3
Bojana Jakic, Maja Buszko, Giuseppe Cappellano, Georg Wick
Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products)...
2017: PloS One
https://www.readbyqxmd.com/read/28600769/methods-for-real-time-pcr-based-diagnosis-of-chlamydia-pneumoniae-chlamydia-psittaci-and-chlamydia-abortus-infections-in-an-opened-molecular-diagnostic-platform
#4
Onya Opota, René Brouillet, Gilbert Greub, Katia Jaton
The advances in molecular biology of the last decades have dramatically improved the field of diagnostic bacteriology. In particular, PCR-based technologies have impacted the diagnosis of infections caused by obligate intracellular bacteria such as pathogens from the Chlamydiacae family. Here, we describe a real-time PCR-based method using the Taqman technology for the diagnosis of Chlamydia pneumoniae, Chlamydia psittaci, and Chlamydia abortus infection. The method presented here can be applied to various clinical samples and can be adapted on opened molecular diagnostic platforms...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28577241/human-infectious-diseases-and-risk-of-preeclampsia-an-updated-review-of-the-literature
#5
REVIEW
Malihe Nourollahpour Shiadeh, Zahra Behboodi Moghadam, Ishag Adam, Vafa Saber, Maryam Bagheri, Ali Rostami
BACKGROUND: Preeclampsia (PE) is one of the major causes of maternal and perinatal morbidity and mortality, especially in low- and middle-income countries. In recent years, a growing body of literatures suggests that infections by bacteria, viruses, and parasites and their related inflammations play an important role in the pathogenesis of PE. METHODS: We searched PubMed, Google scholar, and Cochrane databases using the following search words: "infection and preeclampsia," "bacterial infection and preeclampsia," "viral infection and preeclampsia" and "parasitic infection and preeclampsia...
June 2, 2017: Infection
https://www.readbyqxmd.com/read/28568680/mucositis-secondary-to-chlamydia-pneumoniae-infection-expanding-the-mycoplasma-pneumoniae-induced-rash-and-mucositis-concept
#6
Ander Mayor-Ibarguren, Marta Feito-Rodriguez, Jéssica González-Ramos, Teresa Del Rosal-Rabes, Francisco Javier González-Sainz, Alba Sánchez-Orta, Raul de Lucas-Laguna
The term Mycoplasma pneumoniae-induced rash and mucositis (MIRM) was recently proposed to identify the mucocutaneous condition secondary to M. pneumoniae infection that had historically been regarded among the more confusing pathologies of erythema multiforme and Stevens-Johnson syndrome. Based on a number of previous reports, these syndromes require differentiation since they have different prognoses and specific treatment requirements. We report a case of oral and genital erosions that strongly resembled MIRM without rash but were found to be secondary to a Chlamydia pneumoniae infection...
June 1, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28555934/activity-of-synthetic-peptides-against-chlamydia
#7
Manuela Donati, Giovanna Cenacchi, Roberta Biondi, Valentina Papa, Nicole Borel, Edoardo Vecchio Nepita, Simone Magnino, Gianandrea Pasquinelli, Aurora Levi, Octavio L Franco
The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from 8 different species tested by ≥50% at 10 µg.ml(-1) . Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus and C. avium even at 80 µg.ml(-1) . These data suggest that clavanin MO could be a promising compound in the prevention and treatment of chlamydial infections...
May 27, 2017: Biopolymers
https://www.readbyqxmd.com/read/28526018/infection-mediated-asthma-etiology-mechanisms-and-treatment-options-with-focus-on-chlamydia-pneumoniae-and-macrolides
#8
REVIEW
Wilmore C Webley, David L Hahn
Asthma is a chronic respiratory disease characterized by reversible airway obstruction and airway hyperresponsiveness to non-specific bronchoconstriction agonists as the primary underlying pathophysiology. The worldwide incidence of asthma has increased dramatically in the last 40 years. According to World Health Organization (WHO) estimates, over 300 million children and adults worldwide currently suffer from this incurable disease and 255,000 die from the disease each year. It is now well accepted that asthma is a heterogeneous syndrome and many clinical subtypes have been described...
May 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28480606/chlamydia-pneumoniae-induces-interferon-gamma-responses-in-peripheral-blood-mononuclear-cells-in-children-with-allergic-asthma
#9
Tamar A Smith-Norowitz, Diana Weaver, Valeriy Chorny, Yitzchok M Norowitz, Danielle Lent, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Respiratory infections caused by Chlamydia pneumoniae have been associated with exacerbations of asthma. Cell mediated immunity (CMI) is critical for maintaining immunity. We compared Interferon (IFN)-γ responses in C. pneumoniae-infected peripheral blood mononuclear cells (PBMC) in pediatric patients +/- asthma. Presence of C. pneumoniae was tested from asthma patients (N=17) and non-asthmatic controls (N=16) (PCR). PBMC were infected for 1 hr +/- C. pneumoniae AR-39 (MOI = 0.1), and cultured for 48 hrs. IFN-γ levels were measured in supernatants (ELISA)...
May 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28480285/influence-of-antibiotics-on-the-detection-of-bacteria-by-culture-based-and-culture-independent-diagnostic-tests-in-patients-hospitalized-with-community-acquired-pneumonia
#10
Aaron M Harris, Anna M Bramley, Seema Jain, Sandra R Arnold, Krow Ampofo, Wesley H Self, Derek J Williams, Evan J Anderson, Carlos G Grijalva, Jonathan A McCullers, Andrew T Pavia, Richard G Wunderink, Kathryn M Edwards, Jonas M Winchell, Lauri A Hicks
BACKGROUND: Specimens collected after antibiotic exposure may reduce culture-based bacterial detections. The impact on culture-independent diagnostic tests is unclear. We assessed the effect of antibiotic exposure on both of these test results among patients hospitalized with community-acquired pneumonia (CAP). METHODS: Culture-based bacterial testing included blood cultures and high-quality sputum or endotracheal tube (ET) aspirates; culture-independent testing included urinary antigen testing (adults) for Streptococcus pneumoniae and Legionella pneumophila and polymerase chain reaction (PCR) on nasopharyngeal and oropharyngeal (NP/OP) swabs for Mycoplasma pneumoniae and Chlamydia pneumoniae...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475737/evolution-of-acute-infection-with-atypical-bacteria-in-a-prospective-cohort-of-children-with-community-acquired-pneumonia-receiving-amoxicillin
#11
Cristiana M Nascimento-Carvalho, Gabriel Xavier-Souza, Ana-Luisa Vilas-Boas, Maria-Socorro H Fontoura, Aldina Barral, Mirja Puolakkainen, Olli Ruuskanen
Background: Atypical bacteria are treatable causative agents of community-acquired pneumonia (CAP). However, there is no conclusive evidence that a child with CAP should receive empirical treatment against such agents. Objectives: We assessed the possibility of association between clinical failure and acute infection by these bacteria among children with CAP treated with amoxicillin. Patients and methods: Patients aged 2-59 months with non-severe CAP received amoxicillin during prospective follow-up...
May 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28435302/in-situ-detection-of-chlamydia-pneumoniae-c-trachomatis-and-cytokines-among-cardiovascular-diseased-patients-from-the-amazon-region-of-brazil
#12
Larissa S Freitas, Núbia Caroline C Almeida, Maria Alice Freitas Queiroz, Marcelo M Zaninotto, Hellen T Fuzii, Alfredo Ribeiro-Silva, Antonio Cr Vallinoto, Marluísa Og Ishak, Juarez As Quaresma, Ricardo Ishak
BACKGROUND: Chronic coronary artery disease has been associated, as a consequence of the local inflammatory reaction with previous or persistent infection with Chlamydia pneumoniae, which led to the investigation of the association of cardiovascular disease and previous infection with C. trachomatis and the role of cytokine profile (in situ) markers in the vascular system tissues. METHODS: Sixty-nine biopsies were collected for immunohistochemical analysis for the presence of IL-6, IL-8, TNF-α, IFN-γ, TGF-β, and IL-10, in 16 fragments from atheromatous plaques, 32 aorta fragments, and 21 valve fragments, using a tissue microarray technique for paraffin embedded tissues...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28400772/sphingolipids-are-dual-specific-drug-targets-for-the-management-of-pulmonary-infections-perspective
#13
REVIEW
Lalita Sharma, Hridayesh Prakash
Sphingolipids are the major constituent of the mucus secreted by the cells of epithelial linings of lungs where they maintain the barrier functions and prevent microbial invasion. Sphingolipids are interconvertible, and their primary and secondary metabolites have both structural and functional roles. Out of several sphingolipid metabolites, sphingosine-1 phosphate (S1P) and ceramide are central molecules and decisive for sphingolipid signaling. These are produced by enzymatic activity of sphingosine kinase-1 (SK-1) upon the challenge with either biological or physiological stresses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28396349/biochemical-and-genetic-analysis-of-the-chlamydia-groel-chaperonins
#14
Melissa Illingworth, Anna J Hooppaw, Lu Ruan, Derek J Fisher, Lingling Chen
Chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. The paradigm Escherichia coli chaperonin, EcGroEL, and its cochaperonin, EcGroES, assist in the folding of proteins via an ATP-dependent mechanism. In addition to the presence of groEL and groES homologs, groEL paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. Chlamydia spp...
June 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28387800/molecular-characterization-of-chlamydia-pneumoniae-associated-to-atherosclerosis
#15
Loubna El Yazouli, Alexis Criscuolo, Hicham Hejaji, Mohamed Bouaaza, Naima Elmdaghri, Aziz Aroussi Alami, Abderahim Amraoui, Nadia Dakka, Fouzia Radouani
Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. The main objective of our study was to evaluate the association between Chlamydia pneumoniae and atherosclerosis in Moroccan patients through a case/control approach and detected strain genotyping. A total of 137 cases and 124 controls were enrolled, nested PCR was performed for Chlamydia pneumoniae screening of the peripheral blood mononuclear cells (PBMCs) of both cases and controls as well as atheroma plaques from 37 cases, and positive samples were subjected to sequencing for genotyping and phylogenetic analysis...
April 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28377051/chlamydia-pneumoniae-infection-promotes-vascular-endothelial-cell-angiogenesis-through-an-iqgap1-related-signaling-pathway
#16
Beibei Wang, Lijun Zhang, Jingya Liu, Lu Ma, Haiwei Wang, Ningbo Zheng, Xiaoyu Chen, Bingling Shen, Zhelong Xu, Lijun Zhang
Chlamydia pneumoniae (C. pneumoniae) infection plays a potential role in angiogenesis. However, it is still an enigma how C. pneumoniae is involved in this process. Therefore, we investigated the effect of C. pneumoniae infection on angiogenesis, and then explored the roles of IQGAP1-related signaling in C. pneumoniae infection-induced angiogenesis. C. pneumoniae infection significantly enhanced angiogenesis as assessed by the tube formation assay possibly by inducing vascular endothelial cell (VEC) migration in the wound healing and Transwell migration assays...
June 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28365060/clinical-evaluation-of-a-new-single-tube-multiplex-reverse-transcription-pcr-assay-for-simultaneous-detection-of-11-respiratory-viruses-mycoplasma-pneumoniae-and-chlamydia-in-hospitalized-children-with-acute-respiratory-infections
#17
Meng-Chuan Zhao, Gui-Xia Li, Dan Zhang, Hang-Yu Zhou, Hao Wang, Shuo Yang, Le Wang, Zhi-Shan Feng, Xue-Jun Ma
Respiratory Pathogen 13 Detection Kit (13× kit) is able to simultaneously detect 11 respiratory viruses, Mycoplasma pneumoniae (MP) and Chlamydia in a single reaction. Using 572 Nasopharyngeal aspirates collected from hospitalized children, the clinical performance of 13× kit for detecting 11 respiratory viruses was evaluated in comparison with a routinely used 2-tube multiplex reverse transcription PCR assay (2-tube assay) at provincial Centers for Disease Control and Prevention in China. The clinical performance of 13× kit for detecting MP and Chlamydia was evaluated by commercial real-time quantitative PCR (qPCR) kits or sequencing...
March 22, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28330238/isolation-of-antimicrobial-resistant-bacteria-in-upper-respiratory-tract-infections-of-patients
#18
Li-Min Wang, Xiao-Liang Qiao, Liang Ai, Jing-Jing Zhai, Xue-Xia Wang
Haemophilus influenzae, Streptococcus pyogenes, Moraxella catarrhalis, Staphylococcus aureus, and Streptococcus pneumoniae are usual cause of upper respiratory tract infection cases. The present study aims the isolation of bacterial strains which are resistant to the commonly prescribed antibiotics. In total, 900 throat swabs were obtained from the patients suffering from upper respiratory tract infections residing in three different localities. The maximum number of isolates (64 %) were obtained from locality-1 (L-1), whereas lowest isolates were found in second locality (L-2)...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28277149/in-vitro-activity-of-a-partially-purified-and-characterized-bark-extract-of-castanea-sativa-mill-enc%C3%A2-against-chlamydia-spp
#19
Valentina Papa, Laura Ginocchietti, Roberta Budriesi, Matteo Micucci, Roberta Costa, Roberta Biondi, Roberto Cevenini, Alberto Chiarini, Rita Aldini, Manuela Donati, Gian Matteo Pollini, Giovanna Cenacchi
Castanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae. The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C...
March 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28264910/expanding-role-of-type-ii-secretion-in-bacterial-pathogenesis-and-beyond
#20
REVIEW
Nicholas P Cianciotto, Richard C White
Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria, occurring in many, but not all, genera in the Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, and Deltaproteobacteria classes. Prominent human and/or animal pathogens that express a T2S system(s) include Acinetobacter baumannii, Burkholderia pseudomallei, Chlamydia trachomatis, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Vibrio cholerae, and Yersinia enterocolitica T2S-expressing plant pathogens include Dickeya dadantii, Erwinia amylovora, Pectobacterium carotovorum, Ralstonia solanacearum, Xanthomonas campestris, Xanthomonas oryzae, and Xylella fastidiosa T2S also occurs in nonpathogenic bacteria, facilitating symbioses, among other things...
May 2017: Infection and Immunity
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