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Chlamydia pneumoniae

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https://www.readbyqxmd.com/read/27916800/lead-discovery-strategies-for-identification-of-chlamydia-pneumoniae-inhibitors
#1
REVIEW
Leena Hanski, Pia Vuorela
Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to its well-known propensity for persistence and recent reports on antimicrobial resistence within closely related species, new approaches for targeting this ubiquitous human pathogen are urgently needed. In this review, we describe the strategies that have been successfully applied for the identification of nonconventional antichlamydial agents, including target-based and ligand-based virtual screening, ethnopharmacological approach and pharmacophore-based design of antimicrobial peptide-mimicking compounds...
November 28, 2016: Microorganisms
https://www.readbyqxmd.com/read/27894280/is-there-any-association-between-sarcoidosis-and-infectious-agents-a-systematic-review-and-meta-analysis
#2
Tiago Esteves, Gloria Aparicio, Vicente Garcia-Patos
BACKGROUND: During the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. With the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement from the Cochrane collaboration guidelines...
November 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27819396/lack-of-association-of-chlamydia-pneumoniae-with-cardiovascular-diseases-in-virologically-suppressed-hiv-patients
#3
Rosa Sessa, Marisa Di Pietro, Simone Filardo, Alessia Bressan, Laura Mazzuti, Sara Serafino, Alessandra Fantauzzi, Ombretta Turriziani
Cardiovascular disease (CVD) is a major public health problem in developed countries with over 17 million deaths per year. In the last decade, several infectious agents rather than any single pathogen, including Chlamydia pneumoniae and human immunodeficiency virus (HIV), have been shown to contribute to the development of atherosclerosis and subsequent cardiovascular events by inducing systemic inflammation and/or acting directly on the vascular wall. For the first time, we evaluated C. pneumonia DNA in peripheral blood mononuclear cells from HIV patients by real-time polymerase chain reaction in order to shed light on C...
November 7, 2016: New Microbiologica
https://www.readbyqxmd.com/read/27817213/progress-and-future-opportunities-in-the-development-of-vaccines-against-atherosclerosis
#4
Dania Govea-Alonso, Josué Beltrán-López, Jorge A Salazar-González, Juan Vargas-Morales, Sergio Rosales-Mendoza
Atherosclerosis represents a serious global health problem that demands new therapeutic and prophylactic interventions. Considering that atherosclerosis has autoimmune and inflammatory components, immunotherapy is a possible focus to treat this disease. Areas covered: Based on the analysis of the current biomedical literature, this review describes the status on the development of vaccines against atherosclerosis. Several targets have been identified including sequences of apolipoprotein B100 (ApoB100), cholesteryl ester transfer protein (CETP), heat shock proteins (HSP), extracellular matrix proteins, T cell receptor β chain variable region 31 (TRBV31), the major outer membrane protein (MOMP), and the outer membrane protein 5 (Pomp5) from Chlamydia pneumoniae...
November 6, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27803507/role-of-atypical-bacteria-in-hospitalized-patients-with-nursing-home-acquired-pneumonia
#5
Laura Meyer-Junco
Background: Nursing home-acquired pneumonia (NHAP) has been identified as one of the leading causes of mortality and hospitalization for long-term care residents. However, current and previous pneumonia guidelines differ on the appropriate management of NHAP in hospitalized patients, specifically in regard to the role of atypical bacteria such as Chlamydiae pneumonia, Mycoplasma pneumoniae, and Legionella. Objectives: The purpose of this review is to evaluate clinical trials conducted in hospitalized patients with NHAP to determine the prevalence of atypical bacteria and thus the role for empiric antibiotic coverage of these pathogens in NHAP...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27786615/simkania-negevensis-an-insight-into-the-biology-and-clinical-importance-of-a-novel-member-of-the-chlamydiales-order
#6
Manon Vouga, David Baud, Gilbert Greub
Simkania negevensis is a Chlamydia-related bacterium discovered in 1993 and represents the founding member of the Simkaniaceae family within the Chlamydiales order. As other Chlamydiales, it is an obligate intracellular bacterium characterized by a biphasic developmental cycle. Its similarities with the pathogenic Chlamydia trachomatis and Chlamydia pneumoniae make it an interesting bacterium. So far, little is known about its biology, but S. negevensis harbors various microbiological characteristics of interest, including a strong association of the Simkania-containing vacuole with the ER and the presence of an intron in the 23S rRNA encoding gene...
October 27, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27754466/natural-products-for-the-treatment-of-chlamydiaceae-infections
#7
Mika A Brown, Michael G Potroz, Seoh-Wei Teh, Nam-Joon Cho
Due to the global prevalence of Chlamydiae, exploring studies of diverse antichlamydial compounds is important in the development of effective treatment strategies and global infectious disease management. Chlamydiaceae is the most widely known bacterial family of the Chlamydiae order. Among the species in the family Chlamydiaceae, Chlamydia trachomatis and Chlamydia pneumoniae cause common human diseases, while Chlamydia abortus, Chlamydia psittaci, and Chlamydia suis represent zoonotic threats or are endemic in human food sources...
October 16, 2016: Microorganisms
https://www.readbyqxmd.com/read/27753796/etiology-of-acute-respiratory-infections-in-infants-a-prospective-birth-cohort-study
#8
Prawin Kumar, Guruprasad R Medigeshi, Vishnu S Mishra, Mojahidul Islam, Shivani Randev, Aparna Mukherjee, Rama Chaudhry, Arti Kapil, Kana Ram Jat, Rakesh Lodha, Sushil K Kabra
BACKGROUND: There is paucity of studies on etiology of acute respiratory infections (ARI) in infants. OBJECTIVE: To document incidence and etiology of ARI in infants, their seasonal variability and association of clinical profile with etiology. MATERIAL AND METHODS: A birth cohort was followed for the first year of life; for each episode of ARI, nasopharyngeal aspirates were collected to identify the causative respiratory virus/es using multiplex real time PCR assay...
October 6, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27742734/pleuromutilins-potent-drugs-for-resistant-bugs-mode-of-action-and-resistance
#9
Susanne Paukner, Rosemarie Riedl
Pleuromutilins are antibiotics that selectively inhibit bacterial translation and are semisynthetic derivatives of the naturally occurring tricyclic diterpenoid pleuromutilin, which received its name from the pleuromutilin-producing fungus Pleurotus mutilus Tiamulin and valnemulin are two established derivatives in veterinary medicine for oral and intramuscular administration. As these early pleuromutilin drugs were developed at a time when companies focused on major antibacterial classes, such as the β-lactams, and resistance was not regarded as an issue, interest in antibiotic research including pleuromutilins was limited...
October 14, 2016: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/27728851/association-between-infectious-burden-socioeconomic-status-and-ischemic-stroke
#10
Frederick Palm, Pirkko J Pussinen, Annette Aigner, Heiko Becher, Florian Buggle, Matthias F Bauer, Caspar Grond-Ginsbach, Anton Safer, Christian Urbanek, Armin J Grau
BACKGROUND AND AIMS: Infectious diseases contribute to stroke risk, and are associated with socioeconomic status (SES). We tested the hypotheses that the aggregate burden of infections increases the risk of ischemic stroke (IS) and partly explains the association between low SES and ischemic stroke. METHODS: In a case-control study with 470 ischemic stroke patients and 809 age- and sex-matched controls, randomly selected from the population, antibodies against the periodontal microbial agents Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, against Chlamydia pneumonia, Mycoplasma pneumoniae (IgA and IgG), and CagA-positive Helicobacter pylori (IgG) were assessed...
October 5, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27727592/to-study-the-association-between-anti-chlamydia-pneumoniae-antibodies-igg-anti-mycoplasma-pneumoniae-antibodies-igg-and-coronary-artery-disease-cad
#11
N S Kochar, S Garg, A Oberoi, S Chopra
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27712463/peptide-19-of-porphyromonas-gingivalis-heat-shock-protein-is-a-potent-inducer-of-low-density-lipoprotein-oxidation
#12
Ji-Young Joo, Gil Sun Cha, Jin Chung, Ju-Youn Lee, Sung-Jo Kim, Jeomil Choi
BACKGROUND: Although periodontal pathogens show a strong association with the development of atherosclerosis, little is known about how a microorganism contributes to disease onset and progression. Oxidation of low-density lipoprotein (LDL) is a major risk factor of atherogenesis. The principal objective of our study was to evaluate the ability of peptide 19 (Pep19) of Porphyromonas gingivalis (P. gingivalis) heat shock protein (HSP) as a potent inducer of LDL oxidation, and as a secondary objective, to compare this ability with that of Pep19 from different bacteria...
October 7, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27681924/coinfection-of-chlamydiae-and-other-bacteria-in-reactive-arthritis-and-spondyloarthritis-need-for-future-research
#13
REVIEW
Henning Zeidler, Alan P Hudson
Reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen Chlamydia trachomatis in some individuals. Recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen Chlamydia pneumoniae, can elicit a similar arthritis. Studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. However, reports focusing on coinfections with these and/or other organisms, and the effects of such coinfections on the host immune and other systems, have been rare...
August 24, 2016: Microorganisms
https://www.readbyqxmd.com/read/27631978/analysis-of-polymorphic-membrane-protein-expression-in-cultured-cells-identifies-pmpa-and-pmph-of-chlamydia-psittaci-as-candidate-factors-in-pathogenesis-and-immunity-to-infection
#14
Sarah Van Lent, Winnok H De Vos, Heather Huot Creasy, Patricia X Marques, Jacques Ravel, Daisy Vanrompay, Patrik Bavoil, Ru-Ching Hsia
The polymorphic membrane protein (Pmp) paralogous families of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia abortus are putative targets for Chlamydia vaccine development. To determine whether this is also the case for Pmp family members of C. psittaci, we analyzed transcription levels, protein production and localization of several Pmps of C. psittaci. Pmp expression profiles were characterized using quantitative real-time PCR (RT-qPCR), immunofluorescence (IF) and immuno-electron microscopy (IEM) under normal and stress conditions...
2016: PloS One
https://www.readbyqxmd.com/read/27627462/recent-advances-and-future-directions-in-understanding-and-treating-chlamydia-induced-reactive-arthritis
#15
John D Carter, Alan P Hudson
INTRODUCTION: Reactive arthritis (ReA) is an inflammatory disease that can follow gastrointestinal or genitourinary infections. The primary etiologic agent for post-venereal ReA is the bacterium Chlamydia trachomatis; its relative, C pneumoniae, has also been implicated in disease induction although to a lesser degree. Studies have indicated that the arthritis is elicited by chlamydiae infecting synovial tissue in an unusual biologic state designated persistence. We review clinical aspects, host-pathogen interactions, and treatments for the disease...
September 14, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27622024/investigating-potential-exogenous-tumor-initiating-and-promoting-factors-for-cutaneous-t-cell-lymphomas-ctcl-a-rare-skin-malignancy
#16
REVIEW
Ivan V Litvinov, Anna Shtreis, Kenneth Kobayashi, Steven Glassman, Matthew Tsang, Anders Woetmann, Denis Sasseville, Niels Ødum, Madeleine Duvic
Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV)...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27620382/birds-of-a-feather-an-uncommon-cause-of-pneumonia-and-meningoencephalitis
#17
Anne-Marie Ionescu, Divya Khare, Jay Kavi
A 61-year-old man was admitted with a 1-week history of influenza-like symptoms during a period of increased influenza virus activity. He soon developed type 2 respiratory failure and became increasingly drowsy. He later suffered a convulsive episode in the intensive care unit (ICU) which self-terminated. Initial clinical findings suggested community-acquired pneumonia and meningoencephalitis. However, a detailed history revealed that he was a pet bird-keeper, which raised a suspicion of ornithosis. Chlamydia psittaci DNA was detected in sputum by PCR...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27611675/chlamydia-pneumoniae-cpj0783-interaction-with-huntingtin-protein14
#18
Izumi Yanatori, Yumiko Yasui, Kazunobu Ouchi, Fumio Kishi
Chlamydia pneumoniae is a Gram-negative, obligate intracellular pathogen that causes community-acquired respiratory infections. After C. pneumoniae invades host cells, it disturbs the vesicle transport system to escape host lysosomal or autophagosomal degradation. By using a yeast mis-sorting assay, we found 10 C. pneumoniae candidate genes involved in aberrant vesicular trafficking in host cells. One of the candidate genes, CPj0783, was recognized by antibodies from C. pneumoniae-infected patients. The expression of CPj0783 was detected at mid to late-cycle time points and increased during the inclusion maturation...
December 2015: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/27599935/chlamydia-pecorum-is-the-endemic-intestinal-species-in-cattle-while-c-gallinacea-c-psittaci-and-c-pneumoniae-associate-with-sporadic-systemic-infection
#19
Jing Li, Weina Guo, Bernhard Kaltenboeck, Konrad Sachse, Yi Yang, Guangwu Lu, Jilei Zhang, Lu Luan, Jinfeng You, Ke Huang, Haixiang Qiu, Yaoyao Wang, Min Li, Zhangping Yang, Chengming Wang
To investigate the prevalence and diversity of bovine Chlamydia spp. in cattle, whole blood from dairy and beef cattle in 11 provinces of China (n=2003) and vaginal swabs, whole blood samples, feces, milk samples from cows in a Yangzhou dairy farm (n=108) were examined using genus- and species-specific PCRs. In cattle from 11 provinces, 2.4% (48/2003) of whole-blood samples were positive for Chlamydia spp., and four Chlamydia species (C. pneumoniae, 41.7%, 20/48; C. psittaci, 22.9%, 11/48; C. gallinacea, 20...
September 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27582738/biophysical-and-biochemical-outcomes-of-chlamydia-pneumoniae-infection-promotes-pro-atherogenic-matrix-microenvironment
#20
Shankar J Evani, Shatha F Dallo, Anand K Ramasubramanian
Multiple studies support the hypothesis that infectious agents may be involved in the pathogenesis of atherosclerosis. Chlamydia pneumoniae is strongly implicated in atherosclerosis, but the precise role has been underestimated and poorly understood due to the complexity of the disease process. In this work, we test the hypothesis that C. pneumoniae-infected macrophages lodged in the subendothelial matrix contribute to atherogenesis through pro-inflammatory factors and by cell-matrix interactions. To test this hypothesis, we used a 3D infection model with freshly isolated PBMC infected with live C...
2016: Frontiers in Microbiology
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