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https://www.readbyqxmd.com/read/29224037/opportunities-for-laser-assisted-drug-delivery-in-the-treatment-of-cutaneous-disorders
#1
Emily Wenande, Andrés Már Erlendsson, Merete Haedersdal
Fractional laser-assisted drug delivery (LADD) is increasingly finding its way into clinical practice as a new means to enhance topical drug uptake and improve treatment of cutaneous disorders. To date, LADD has been used for a wide range of conditions, including photodamaged skin, neoplastic lesions, scars, cutaneous infections, and vitiligo as well as for topical anesthetic and aesthetic procedures. Substantiated by randomized controlled clinical trials, strong evidence is available for LADD's usefulness for photodynamic therapy (PDT), for which improved efficacy using laser-assisted photosensitizer treatment is established for actinic keratosis compared with conventional PDT...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29224036/laser-advances-in-the-treatment-of-burn-and-traumatic-scars
#2
Shilpi Khetarpal, Urvashi Kaw, Jeffrey S Dover, Kenneth A Arndt
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can be used to revitalize and restore damaged skin in atrophic and hypertrophic scars. The most commonly used lasers are the pulsed-dye laser (PDL) and fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29224032/microneedling-a-new-approach-for-treating-textural-abnormalities-and-scars
#3
Sara Hogan, Mara Weinstein Velez, Omer Ibrahim
Microneedling is a minimally invasive procedure wherein small holes are created across the stratum corneum while keeping the epidermis partially intact. This produces microchannels that increase skin permeability and simultaneously stimulate growth factor release. Since the epidermis is retained, microneedling has less risk of infection, postinflammatory hyperpigmentation, and scarring compared to other resurfacing modalities. This is a review of the literature on microneedling in the treatment of textural abnormalities, specifically rhytides, scars, and striae...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29224031/short-pulsed-laser-for-the-treatment-of-tattoos-pigmented-lesions-scars-and-rejuvenation
#4
Emil A Tanghetti, Kristina Andrea Hoffmann, Klaus Hoffmann
This review describes the use of picosecond lasers for the treatment of tattoos, pigmented lesions, scars, and their use in rejuvenation. These devices have delivered enhanced efficacy for the treatment of tattoos and pigmented lesions when compared to the older 40-50 nanosecond devices. The fractional delivery with the picosecond devices have opened up a new method of rejuvenation for photodamaged skin and the treatment of scars. The delivery of these high-energy short pulses have created zones of injury in the skin referred to as areas of laser-induced optical breakdown...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29224030/advances-in-fractional-technology-for-skin-rejuvenation-skin-tightening-drug-delivery-and-treating-scars-and-skin-defects
#5
Deirdre Connolly, Laura Schilling, Nazanin Saedi
The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29223734/activation-of-the-epor-%C3%AE-common-receptor-complex-by-cibinetide-ameliorates-impaired-wound-healing-in-mice-with-genetic-diabetes
#6
Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Giovanni Pallio, Federica Mannino, Mario Vaccaro, Vincenzo Arcoraci, Federica Aliquò, Letteria Minutoli, Michele R Colonna, Maria Rosaria Galeano, Michael Brines, Chiara De Ponte, Massimo Collino, Francesco Squadrito, Domenica Altavilla
Diabetes is characterized by poor wound healing which currently lacks an efficacious treatment. The innate repair receptor (IRR) is a master regulator of tissue protection and repair which is expressed as a response injury or metabolic stress, including in diabetes. Activation of the IRR might provide benefit for diabetic wound healing. A specific IRR agonist cibinetide was administered in an incisional wound healing model performed mice with genetic diabetes (db+/db+) and compared to the normal wild-type. Animals were treated daily with cibinetide (30μg/kg/s...
December 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29223674/prediction-of-need-for-intervention-in-posterior-urethral-valves-use-of-urine-osmolality
#7
Anna E Wright, Ruth Wragg, Joana Lopes, Andrew Robb, Liam McCarthy
AIM: Renal tubular dysfunction (RTD) causing obligate production of hypoosmolar urine in boys with posterior urethral valves (PUVs) has been described. It is not known how clinically significant this is. We hypothesize that a feedback loop is present in many PUV boys who suffer deterioration of their lower urinary tract (LUT). RTD results in hypoosmolar urine, obligate polyuria, and bladder stretch-injury. The increasing back-pressure worsens RTD, thus exacerbating the injury. Coexisting renal dysplasia and acquired renal scarring exacerbate this...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223609/-recurrent-postpartum-pyoderma-gangrenosum-and-fatal-cardiomyopathy
#8
I Naciri, M Meziane, L Benzekri, M Ghaouti, K Senouci, B Hassam
BACKGROUND: We report a case of recurrent post-partum pyoderma gangrenosum (PG) complicated by post-partum cardiomyopathy (PPCM). PATIENTS AND METHODS: A 23-year-old woman presented with a previous medical history of aseptic abscess of the left breast in her fourth pregnancy, which developed after surgical drainage of an inflammatory ulceration treated by atraumatic topical care. During her fifth pregnancy, the patient presented a large and painful ulceration in relation to the scar of the Caesarean section, despite the introduction of broad-spectrum antibiotic therapy...
December 6, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29223423/the-requirement-of-sutures-to-close-intercostal-drains-site-wounds-in-thoracic-surgery
#9
Jeremy L C Smelt, Natalie Simon, Lukacs Veres, Karen Harrison-Phipps, Andrea Bille
BACKGROUND: Chest drains are used routinely in thoracic surgery. Often a pursestring or mattress suture is used to facilitate closure of the defect on removal of the drain. This stitch can cause an unsightly scar, increase drain removal pain, and necessitate that the patient attend a community health care center to have this removed. The objective of this study was to assess whether this stitch is necessary in modern thoracic surgical practice. METHODS: Data from a single surgeon's practice were collected over an 18-month period...
December 6, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29223322/systemic-administration-of-epothilone-d-improves-functional-recovery-of-walking-after-rat-spinal-cord-contusion-injury
#10
Jörg Ruschel, Frank Bradke
Central nervous system (CNS) injuries cause permanent impairments of sensorimotor functions as mature neurons fail to regenerate their severed axons. The poor intrinsic growth capacity of adult CNS neurons and the formation of an inhibitory lesion scar are key impediments to axon regeneration. Systemic administration of the microtubule stabilizing agent epothilone B promotes axon regeneration and recovery of motor function by activating the intrinsic axonal growth machinery and by reducing the inhibitory fibrotic lesion scar...
December 6, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29223224/combined-interface-tattooing-and-fibrin-glue-assisted-sutureless-corneal-resurfacing-with-donor-lenticule-obtained-from-small-incision-lenticule-extraction-for-limbal-dermoid
#11
Soosan Jacob, Smita Narasimhan, Amar Agarwal, Athiya Agarwal, Saijimol Ai
We describe a technique of small-incision lenticule extraction (SMILE)-assisted sutureless corneal resurfacing with interface tattooing for superficial limbal dermoids. After excision at a plane minimally below surrounding normal cornea and sclera, a corneal tattoo powder is carefully applied within an inked circular outline of the intended corneal margin. Circularity and cosmesis are assessed in natural light with the microscope light off. Fibrin glue-assisted corneal resurfacing is performed with the lenticule...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29222875/the-incidence-and-outcomes-of-delayed-response-to-cardiac-resynchronization-therapy
#12
Kebei Li, Zhiyong Qian, Xiaofeng Hou, Yao Wang, Yuanhao Qiu, Yufeng Sheng, Xuesong Qian, Yong Zhou, Jiangang Zou
BACKGROUND: The incidence and clinical outcomes of delayed response to cardiac resynchronization therapy (CRT) have not been well clarified. We aimed to observe the incidence and prognosis of delayed response and to identify its possible mechanisms. METHODS: A total of 115 CRT patients were retrospectively analyzed in our study. Patients who met the enrollment criteria were divided into 2 groups: group A, conventional responders who showed response at 1-year follow-up, and group B, delayed responders who showed response after 1-year follow-up...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222864/effects-of-cardiac-resynchronization-therapy-after-inferior-myocardial-infarction-on-secondary-mitral-regurgitation-and-mitral-valve-geometry
#13
Christos G Mihos, Evin Yucel, Romain Capoulade, Mary P Orencole, Gaurav A Upadhyay, Orlando Santana, Jagmeet P Singh, Michael H Picard
BACKGROUND: The effects of cardiac resynchronization therapy (CRT) on secondary mitral regurgitation (MR), and mitral valve (MV) and left ventricular (LV) geometry, in patients with prior inferior myocardial infarction is not clearly defined. We assessed these outcomes utilizing 2-dimensional echocardiography, and analyzed echocardiographic geometric variables that may correlate with follow-up MR severity. METHODS: Between 2009 and 2012, 229 CRT were implanted. Twenty-two had prior inferior myocardial infarction, ≥ mild MR at baseline, and serial echocardiography...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222072/heparan-sulfate-potentiates-leukocyte-adhesion-on-cardiac-fibroblast-by-enhantcing-vcam-1-and-icam-1-expression
#14
Francisco Olivares-Silva, Rodolfo Landaeta, Pablo Aránguiz, Samir Bolivar, Claudio Humeres, Renatto Anfossi, Raúl Vivar, Pía Boza, Claudia Muñoz, Viviana Pardo-Jiménez, Concepción Peiró, Carlos F Sánchez-Ferrer, Guillermo Díaz-Araya
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the release of various damage-associated molecular patterns (DAMPs) including heparan sulfate (HS), a constituent of the extracellular matrix (ECM), through the TLR4 receptor activation triggering a strong inflammatory response, inducing leukocytes recruitment. This latter cells are responsible of clearing cell debris and releasing cytokines that promote CF differentiation to myofibroblast (CMF), thus initiating scar formation...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29221812/role-of-immune-cells-in-crystal-induced-kidney-fibrosis
#15
REVIEW
Ermanila Dhana, Isis Ludwig-Portugall, Christian Kurts
Chronic kidney diseases can lead to kidney fibrosis, which can be considered a futile attempt of tissue healing to replaces functional kidney tissue with connective tissue, basically forming a scar. Chronic inflammation is a frequent cause of kidney fibrosis. Classical as well as recently discovered immune cell subsets and their molecular mediators have been intensively investigated for their contribution to kidney fibrosis and their potential as therapeutic targets. Here we review the current knowledge about the role of immune cells in crystal-induced renal fibrosis...
December 5, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29221811/matrix-metalloproteinase-functions-in-hepatic-injury-and-fibrosis
#16
REVIEW
Martin Roderfeld
Liver fibrosis is the most common final outcome for chronic liver diseases. The complex pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe, activation and recruitment of immune cells, activation of hepatic stellate cells, and the synthesis of fibrotic extracellular matrix (ECM) components leading to scar formation. Clinical studies and animal models demonstrated that fibrosis can be reversible. In this regard matrix metalloproteinases (MMPs) have been focused as therapeutic targets due to their ability to modulate tissue turnover during fibrogenesis as well as regeneration and, of special interest, due to their influence on cellular behavior like proliferation, gene expression, and apoptosis that, in turn, impact fibrosis and regeneration...
December 5, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29220117/anterior-surface-breakdown-and-implant-extrusion-following-secondary-alloplastic-orbital-implantation-surgery
#17
Shadi Axmann, Dion Paridaens
BACKGROUND: Secondary orbital implantation surgery can be complex due to scarring of the orbital tissues and can be complicated by implant exposure and extrusion. PURPOSE: To evaluate the incidence and risk factors of implant exposure and extrusion following secondary alloplastic orbital implantation surgery in anophthalmic patients. METHODS: Retrospective analysis of a consecutive series of patients who underwent secondary placement of an alloplastic orbital implant by one surgeon between 2001 and 2016 in the Rotterdam Eye Hospital...
December 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29220081/comment-on-longitudinal-transvaginal-ultrasound-evaluation-of-cesarean-scar-niche-incidence-and-depth-in-the-first-two-years-after-single-or-double-layer-uterotomy-closure-a-randomized-controlled-trial
#18
Marco Scioscia, Piergiorgio Iannone, Danila Morano, Giovanni Pontrelli, Pantaleo Greco
We read with interest a recent article published by Bamberg et al. (1) that takes up an interesting issue previously published on the same journal by Kataoka et al. (2) on uterine niche after a cesarean section (CS). These two prospective studies assessed the risk to develop a uterine wall defect at the site of cesarean scar according to the surgical closure technique. This article is protected by copyright. All rights reserved.
December 8, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29219948/asperosaponin-vi-promotes-angiogenesis-and-accelerates-wound-healing-in-rats-via-up-regulating-hif-1%C3%AE-vegf-signaling
#19
Cheng-Gui Wang, Yi-Ting Lou, Min-Ji Tong, Li-Lian Zhang, Zeng-Jie Zhang, Yong-Zeng Feng, Shi Li, Hua-Zi Xu, Cong Mao
Wound therapy remains a clinical challenge due to the complexity of healing pathology and high demand of achieving functional and aesthetically satisfactory scars. Newly formed blood vessels are essential for tissue repair since they can support cells at the wound site with nutrition and oxygen. In this study, we investigated the effects of Asperosaponin VI (ASA VI) isolated from a traditional Chinese medicine, the root of Dipsacus asper Wall, in promoting angiogenesis, as well as its function in wound therapeutics...
December 7, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29219924/combined-laparoscopic-and-perineal-approach-to-omental-interposition-repair-of-complex-rectovaginal-fistula
#20
Hester de Bruijn, Yasuko Maeda, Jamie Murphy, Janindra Warusavitarne, Carolynne J Vaizey
INTRODUCTION: Surgical repair of rectovaginal fistula remains a challenge. Complex and recurrent rectovaginal fistula repairs often fail because of scarring and devascularization of the surrounding tissue. Omental interposition may promote healing by introducing bulky vascularized tissue into the rectovaginal septum. TECHNIQUE: With the patient in the lithotomy position, the rectovaginal septum was dissected transperineally up to the fistula tract and the openings on both vaginal and rectal sides were closed using interrupted, absorbable sutures...
January 2018: Diseases of the Colon and Rectum
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