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https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#1
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451317/ultrasound-guided-microinvasive-carpal-tunnel-release-using-a-novel-retractable-needle-mounted-blade-a-cadaveric-study
#2
Peter D Hebbard, Andrew I T Hebbard, Janos Tomka, Richard Appleyard
Ultrasound (US)-guided microinvasive procedures are defined as those performed via needles without notable scarring. Ten cadaver hands underwent US-guided microinvasive carpal tunnel release using a novel needle-based tool, the micro i-Blade (Summit Medical Products, Inc, Sandy, UT). A US-imaged landmark, the inflexion point of the ligaments distal to the hook of the hamate, was used to position the distal extent of the cut. The transverse carpal ligament was successfully released in all hands without damage to nerves or arteries...
February 16, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29451216/does-combined-therapy-of-curcumin-and-epigallocatechin-gallate-have-a-synergistic-neuroprotective-effect-against-spinal-cord-injury
#3
Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova
Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29451203/a-growing-field-the-regulation-of-axonal-regeneration-by-wnt-signaling
#4
REVIEW
Armando L Garcia, Adanna Udeh, Karthik Kalahasty, Abigail S Hackam
The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone guidance and synaptogenesis throughout the developing central nervous system (CNS). Recently, studies in mammalian and fish model systems have demonstrated that Wnt/β-catenin signaling also promotes axonal regeneration in the adult optic nerve and spinal cord after injury, raising the possibility that Wnt could be developed as a therapeutic strategy...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29451178/involvement-of-epithelial-mesenchymal-transition-in-liver-fibrosis
#5
REVIEW
Kangkang Yu, Qian Li, Guangfeng Shi, Ning Li
Fibrosis of the liver is an inherent wound healing response to chronic liver injury. Regeneration of liver epithelium and restoration of normal liver structure were generally involved in this process. Although the liver has a striking capacity to adapt to damage through tissue repair, excessive accumulation of extracellular matrix during this process often leads to scar tissue formation and subsequent fibrosis. Epithelial to mesenchymal transition (EMT) enables a polarized epithelial cell to undergo multiple changes biochemically and to bear a mesenchymal cell phenotype...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450694/characteristics-of-women-with-mixed-mass-formation-after-evacuation-following-uterine-artery-chemoembolization-for-cesarean-scar-pregnancy
#6
Qiu-Lei Sun, Xiao-Hua Wu, Li Luo, De-Mei Ying, Ying Yang, Zheng-Qiong Chen
PURPOSE: To explore the efficacy of treatment for early cesarean scar pregnancy (CSP) and to evaluate the characteristics of women with subsequent mixed mass formation. METHODS: Women with CSP, who received UACE followed by evacuation, were retrospectively analyzed. Clinical/sonographic characteristics in patients with or without mixed mass formation were compared. RESULTS: From a total of 395 cases, 105 cases had a pregnancy residual with mixed mass formation...
February 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29450466/diagnostic-criteria-of-ulcerative-pyoderma-gangrenosum-a-delphi-consensus-of-international-experts
#7
Emanual Maverakis, Chelsea Ma, Kanade Shinkai, David Fiorentino, Jeffrey P Callen, Uwe Wollina, Angelo Valerio Marzano, Daniel Wallach, Kyoungmi Kim, Courtney Schadt, Anthony Ormerod, Maxwell A Fung, Andrea Steel, Forum Patel, Rosie Qin, Fiona Craig, Hywel C Williams, Frank Powell, Alexander Merleev, Michelle Y Cheng
Importance: Pyoderma gangrenosum is a rare inflammatory skin condition that is difficult to diagnose. Currently, it is a "diagnosis of exclusion," a definition not compatible with clinical decision making or inclusion for clinical trials. Objective: To propose and validate diagnostic criteria for ulcerative pyoderma gangrenosum. Evidence Review: Diagnostic criteria were created following a Delphi consensus exercise using the RAND/UCLA Appropriateness Method...
February 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29447739/native-t1-and-ecv-of-noninfarcted-myocardium-and-outcome-in-patients-with-coronary-artery-disease
#8
Valentina O Puntmann, Gerry Carr-White, Andrew Jabbour, Chung-Yao Yu, Rolf Gebker, Sebastian Kelle, Andreas Rolf, Sabine Zitzmann, Elif Peker, Tommaso D'Angelo, Faraz Pathan, Elen, Silvia Valbuena, Rocio Hinojar, Christophe Arendt, Jagat Narula, Eva Herrmann, Andreas M Zeiher, Eike Nagel
BACKGROUND: Coronary artery disease (CAD) remains the major cause of cardiac morbidity and mortality worldwide, despite the advances in treatment with coronary revascularization and modern antiremodeling therapy. Risk stratification in CAD patients is primarily based on left ventricular volumes, ejection fraction (LVEF), risk scores, and the presence and extent of late gadolinium enhancement (LGE). The prognostic role of T1 mapping in noninfarcted myocardium in CAD patients has not yet been determined...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29447693/infectious-scarring-setting-the-trigger-for-intestinal-inflammation
#9
Andrew M F Johnson, R William DePaolo
The initiating factors that trigger inflammatory bowel disease (IBD) are poorly understood. In a recent paper, Yang et al. (2017) demonstrate that IBD-like syndrome in mice can develop as a consequence of recurrent pathogen infection. Pathogenic triggering of inflammatory disease is a re-emerging concept that has significant therapeutic implications.
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29447326/prospective-study-on-the-outcome-of-the-sphenoid-drill-out-procedure
#10
T Van Zele, B Pauwels, F Dewaele, P Gevaert, C Bachert
BACKGROUND: Chronic sphenoid sinusitis refractory to both medical therapy and sphenoidotomy requires a more extended intervention based on the principles of salvage surgery. Our aim is to describe the sphenoid drill out technique as a sphenoid salvage intervention and to outline its implications on clinical outcome and quality of life. METHODOLOGY: 12 patients with chronic sphenoiditis undergoing a sphenoid drill out procedure were examined by nasal endoscopy preoperatively and postoperatively for one year...
February 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29446840/uncontrolled-blood-pressure-affects-atrial-remodeling-and-adverse-clinical-outcome-in-paroxysmal-atrial-fibrillation
#11
Masashi Kamioka, Naoko Hijioka, Yoshiyuki Matsumoto, Minoru Nodera, Takashi Kaneshiro, Hitoshi Suzuki, Yasuchika Takeishi
BACKGROUND: To investigate the impact of uncontrolled blood pressure (BP) on left atrial (LA) remodeling and clinical outcome after pulmonary vein isolation (PVI) in paroxysmal atrial fibrillation (AF). METHODS: One hundred and one symptomatic paroxysmal AF patients (85 males, 62.2±8.4 year-old) who underwent successful PVI were classified as follows: group 1 (n = 46), no hypertension (HTN); group 2 (n = 36), HTN with controlled BP; and group 3 (n = 19), HTN with uncontrolled BP...
February 15, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29446701/endoscopic-excision-of-benign-facial-masses-in-children-a-review-of-outcomes
#12
Deshka Foster, Tiffany J Sinclair, Jordan S Taylor, Sanjeev Dutta, Hermann P Lorenz, Matias Bruzoni
PURPOSE: Benign masses of the eyebrow and forehead are common in pediatric patients and can result in facial asymmetry, discomfort, or super-infection. Excision is classically conducted via an incision directly over the mass, which can produce sub-optimal cosmesis. Recently, an endoscopic approach using pediatric brow-lift equipment has been adopted. We reviewed our center's experience with endoscopic removal of benign facial lesions and compared these cases with an equivalent series of open cases...
February 15, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29446671/unenhanced-mri-as-an-alternative-to-99m-tc-labeled-dimercaptosuccinic-acid-scintigraphy-in-the-detection-of-pediatric-renal-scarring
#13
Colbey W Freeman, Talissa A Altes, Patrice K Rehm, Eduard E de Lange, Luke Lancaster, John P Mugler, James T Patrie, Sean Corbett, Carlos Leiva-Salinas, Lucia Flors
OBJECTIVE: The purpose of this study was to determine whether unenhanced MRI without sedation is a feasible substitute for dimercaptosuccinic acid (DMSA) scintigraphy in the detection of renal scars in pediatric patients. SUBJECTS AND METHODS: Patients scheduled for 99mTc-labeled DMSA scintigraphy for assessment of possible renal scars were recruited to undergo unenhanced MRI (free-breathing fat-suppressed T2-weighted single-shot turbo spin-echo and T1-weighted gradient-echo imaging, 13 minutes' total imaging time)...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29445602/uniportal-video-assisted-thoracoscopic-surgery-vats-sleeve-resections-for-non-small-cell-lung-cancer-patients-an-observational-prospective-study-and-technique-analysis
#14
Aris Koryllos, Erich Stoelben
Bronchus sleeve resection for operative treatment of non-small cell lung cancer (NSCLC) is a gold standard in modern thoracic surgery in cases of centrally located tumors or hilär lymph node metastases. Advanced instruments and growing surgical experience allowed surgeons to reduce the required incisions (from 3-port to uniportal) and to resect larger and more centrally located malignancies minimal invasively. It is a logical and expected advance in thoracic surgery that video-assisted thoracoscopic surgery (VATS) would be ultimately used also for complex bronchial resections...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29445570/a-new-perspective-on-the-nail-plate-for-treatment-of-ingrown-toenail
#15
Jia Tian, Jin Li, Fabin Wang, Zhenbing Chen
Background: Our routine treatment for ingrown toenail was removal of the surrounding soft tissue and shortening the bone of the distal phalanx. We determined the range and volume of excision based on our experience without an objective standard and routinely performed avulsion of the nail plate. Objective: To take the nail plate as an objective mark during surgical treatment of ingrown toenail to ensure accurate excision. Patients and Methods: Fifteen patients with ingrown toenails were treated with this technique...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29444296/a-longitudinal-study-of-depressive-symptoms-neuropsychological-functioning-and-medical-responsibility-in-youth-with-spina-bifida-examining-direct-and-mediating-pathways
#16
Alexa Stern, Colleen F Bechtel Driscoll, Diana Ohanian, Grayson N Holmbeck
Objective: Given the increased risk for cognitive deficits and development of depressive symptoms in youth with spina bifida (SB), this study aimed to examine two pathways through which depressive symptoms and neuropsychological dysfunction may be associated with medical autonomy in this population: (1) depressive symptoms as predictors of medical autonomy as mediated by attention/executive functioning (the cognitive scarring model), and (2) attention/executive functioning as predictors of medical autonomy as mediated by depressive symptoms (the cognitive vulnerability model)...
February 10, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29443757/various-surgical-techniques-to-create-an-aesthetic-appearance-at-the-donor-site-of-anterolateral-thigh-free-flaps-based-on-the-oblique-branch-twenty-one-clinical-case-reports
#17
Chengliang Deng, Hai Li, Zairong Wei, Wenhu Jin, Kaiyu Nie, Shujun Li, Bihua Wu, Dali Wang
RATIONALE: Reducing the morbidity associated with anterolateral thigh (ALT) donor sites by performing aesthetic restoration has become a popular research topic. Various surgical techniques have been developed allowing for direct closure of the donor site. However, closure techniques for ALT donor sites based on the oblique branch have not been systematically reported. PATIENT CONCERNS: Data from 21 patients (18 males, 3 females) undergoing operative reconstruction with an ALT free flap between January 2016 and December 2016...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443415/comprehensive-assessment-of-the-donor-site-of-the-anterolateral-thigh-flap-a-prospective-study-in-33-patients
#18
Shuang Bai, Zhi-Qiang Zhang, Zhi-Qiang Wang, Zhong-Fei Xu, Wei-Yi Duan, Fa-Yu Liu, Xue-Xin Tan, Chang-Fu Sun
BACKGROUND: The anterolateral thigh (ALT) free flap has been an extremely versatile flap. The purpose of this study was to propose comprehensive functional assessments of the donor site. METHODS: A total of 33 ALT flaps were enrolled prospectively. Objective assessments included isokinetic testing of the knee, and electromyographic examination of the lateral femoral cutaneous nerve (LFCN). The Patient and Observer Scar Assessment Scale (POSAS) was used to subjectively assess the donor-site scar...
February 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29442397/tuberculin-skin-test-versus-interferon-gamma-release-assay-in-refugee-children-a-retrospective-cohort-study
#19
Chris Elliot, Ben Marais, Phoebe Williams, Paul Joshua, Sherri Towle, Graham Hart, Karen Zwi
AIM: The aim of this study was to assist clinicians evaluating refugee children for latent tuberculosis infection (LTBI) by comparing paired tuberculin skin test (TST) and Quantiferon Gold In-Tube (QGIT) test results with clinical management decisions and follow-up data in a large cohort of newly arrived refugee children. METHODS: This was a retrospective analysis of all refugee children (<15 years of age) evaluated for LTBI with both TST and interferon-γ release assay between 2007 and 2010 in the Illawarra-Shoalhaven region of New South Wales, Australia...
February 14, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29442349/18f-fdg-avid-sclerosing-angiomatoid-nodular-transformation-sant-of-spleen-on-pet-ct-a-rare-mimicker-of-metastasis
#20
Punit Sharma
Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare benign vascular tumor of spleen. It consists of multiple angiomatoid nodules surrounded by dense fibrous tissue that often coalesces centrally to form a scar, which is considered to be a characteristic feature. These are usually asymptomatic and incidentally detected on imaging for other underlying pathology. SANTs can be 18F-Fluorodeoxyglucose (18F-FDG) avid on positron emission tomography-computed tomography (PET-CT) and thus can lead to false positive finding in oncological patients...
2018: Nuclear Medicine Review. Central & Eastern Europe
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