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https://www.readbyqxmd.com/read/28231367/fiddler-s-neck-a-review
#1
Calvin W Myint, Amy L Rutt, Robert T Sataloff
Fiddler's neck is a common dermatologic condition associated with instrument use in violin and viola players. It typically manifests as a submandibular and/or supraclavicular lesion. It is a benign condition, but it may be mistaken for lymphedema or a salivary gland malignancy. Otolaryngologists who treat patients with fiddler's neck should be aware of appropriate management protocols and the need to avoid surgical excision. We obtained informed consent from 3 violinists to present their cases as specific examples of fiddler's neck...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28231275/suppression-of-tgf-%C3%AE-pathway-by-pirfenidone-decreases-extracellular-matrix-deposition-in-ocular-fibroblasts-in-vitro
#2
Thomas Stahnke, Bhavani S Kowtharapu, Oliver Stachs, Klaus-Peter Schmitz, Johannes Wurm, Andreas Wree, Rudolf Friedrich Guthoff, Marina Hovakimyan
In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study was the characterization of the fibrotic potential of two subtypes of primary human ocular fibroblasts and the attempt to inhibit fibrotic processes specifically, without impairing cell viability. For fibrosis inhibition we focused on the small molecule pirfenidone, which has been shown to prevent pulmonary fibrosis by the decrease of the expression of TGF-β1, TGF-β2 and TGF-β3 cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28230654/surgical-endoscopy-versus-endoscopic-surgery-for-obesity
#3
Bogdan Silviu Ungureanu, Ştefan Pătraşcu, Valeriu Şurlin, Adrian Săftoiu
BACKGROUND: Obesity treatment options are of great interest worldwide with major developments in the past 20 years. From general surgery to natural orifice transluminal endoscopic surgery intervention nowadays, obesity surgical therapies have surely developed and are now offering a variety of possibilities. AREAS OF UNCERTAINTY: Although surgery is the only proven approach for weight loss, a joint decision between the physician and patient is required before proceeding to such a procedure...
February 3, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28230602/subcutaneous-c-shape-muscular-flap-for-correcting-the-depression-of-alar-base-in-affected-side-in-patients-with-unilateral-complete-cleft-lip-palate-during-primary-surgery
#4
Dandan Wu, Guomin Wang, Ningjuan Ouyang, Yuhen Lin, Yang Chen, Jiewen Dai
PURPOSE: The depression of alar base in affected side in patients with unilateral complete cleft lip/palate (CL/P) is one of common clinical features. In this study, the authors try to explore the effect of subcutaneous C shape muscular flap for correcting the depression of alar base in affected side in patients with unilateral complete CL/P during primary surgery. METHODS: A total of 30 patients with unilateral complete CL/P who received primary correction of the lip nose deformity were included in this study...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28229358/postmastectomy-radiation-therapy-and-breast-reconstruction-with-autologous-tissue
#5
Yasunobu Terao, Koichiro Taniguchi, Miwako Fujii, So Moriyama
Immediate breast reconstruction is an important tool for patients to accept and overcome their breast cancer, as well as for cosmetic reasons. However, its use in patients who require postmastectomy radiation therapy (PMRT) is not yet clear. The purpose of this study was to analyze the effects of PMRT and reconstruction on each other. The time of initiation of PMRT, the prognosis, and the cosmetic results were investigated in patients who underwent immediate reconstruction using autologous tissue. In the case of delayed reconstruction using autologous tissue after PMRT, radiation damage of the chest skin, design of the flap, and cosmetic results were investigated...
February 22, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28229263/exosomes-derived-from-human-amniotic-epithelial-cells-accelerate-wound-healing-and-inhibit-scar-formation
#6
Bin Zhao, Yijie Zhang, Shichao Han, Wei Zhang, Qin Zhou, Hao Guan, Jiaqi Liu, Jihong Shi, Linlin Su, Dahai Hu
Wound healing is a highly orchestrated physiological process consisting of a complex events, and scarless wound healing is highly desired for the development and application in clinical medicine. Recently, we have demonstrated that human amniotic epithelial cells (hAECs) promoted wound healing and inhibited scar formation through a paracrine mechanism. However, exosomes (Exo) are one of the most important paracrine factors. Whether exosomes derived from human amniotic epithelial cells (hAECs-Exo) have positive effects on scarless wound healing have not been reported yet...
February 22, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28228166/methylene-blue-assay-for-estimation-of-regenerative-re-epithelialization-in-vivo
#7
Maresha Milyavsky, Renee Dickie
The rapidity with which epithelial cells cover a wound surface helps determine whether scarring or scar-less healing results. As methylene blue is a vital dye that is absorbed by damaged tissue but not undamaged epidermis, it can be used to assess wound closure. We sought to develop a quantitative methylene blue exclusion assay to estimate the timeframe for re-epithelialization in regenerating appendages in zebrafish and axolotls, two classic model systems of regeneration. Following application of methylene blue to the amputation plane and extensive washing, the regenerating tail was imaged in vivo until staining was no longer visible...
February 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28227429/characterization-of-normal-and-scarred-myocardium-based-on-texture-analysis-of-cardiac-computed-tomography-images
#8
S Antunes, A Esposito, A Palmisanov, C Colantoni, F de Cobelli, A Del Maschio, S Antunes, A Esposito, A Palmisanov, C Colantoni, F de Cobelli, A Del Maschio, A Del Maschio, C Colantoni, F De Cobelli, A Esposito, S Antunes
An accurate detection of myocardial scar using Cardiac CT may have a strong clinical impact; however, the main drawback is the insufficient contrast to noise ratio of delayed iodine enhanced (DIE) CT images, which makes its accurate segmentation (manual as well as automatic) difficult. In this work, we investigate texture parameters applied on the different scans in order to obtain the scans and features that best differentiates normal from scarred myocardium. The experiments on 7 cases of myocarditis show the accuracy of the parameter energy in all scans, as well as the good performance of the angiographic scan (having higher spatial resolution) with different parameters for the segmentation propose...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227423/dynamic-mapping-of-ventricular-function-from-cardiovascular-magnetic-resonance-imaging
#9
Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Alexander Brost, Tom Jackson, Maria Panayiotou, Christopher A Rinaldi, Jonathan M Behar, R James Housden, Kawal S Rhode, Daniel Toth, Peter Mountney
Heart failure is associated with substantial mortality and morbidity and remains the most common diagnosis in older patients. Based on experimental electrophysiologic studies, cardiac resynchronization therapy (CRT) for heart failure results in a maximum resynchronization effect when applied to the most delayed left ventricular (LV) site. Current clinical practice is to identify the optimal site using separate visualisation of scar and activation information. These must be mentally mapped into 3D, which is challenging and time-consuming for the electrophysiologist...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227097/effects-of-geometry-and-material-on-the-insertion-of-very-small-neural-electrode
#10
Shaun P Marshall, Wei-Chen Lin, Paras R Patel, Albert J Shih, Cynthia A Chestek, Shaun P Marshall, Wei-Chen Lin, Paras R Patel, Albert J Shih, Cynthia A Chestek, Wei-Chen Lin, Shaun P Marshall, Cynthia A Chestek, Albert J Shih, Paras R Patel
For neural probes to be used chronically for years in the human body, they must provoke minimal scarring. Recently, a number of groups have reported substantially reduced scar tissue using cellular scale electrodes below 15 μm in size. This size scale is accessible to manufacturing techniques, but can be very difficult to insert in the brain for most common electrode materials. In this study, we explore the design space available to cellular scale electrodes that will self-insert into the brain. First a mathematical model is developed using beam buckling equations for different materials and geometries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226865/electrical-resistance-increases-at-the-tissue-electrode-interface-as-an-early-response-to-nucleus-accumbens-deep-brain-stimulation
#11
Rajas P Kale, Abbas Z Kouzani, Julian Berk, Ken Walder, Michael Berk, Susannah J Tye, Rajas P Kale, Abbas Z Kouzani, Julian Berk, Ken Walder, Michael Berk, Susannah J Tye, Julian Berk, Michael Berk, Susannah J Tye, Abbas Z Kouzani, Rajas P Kale, Ken Walder
The therapeutic actions of deep brain stimulation are not fully understood. The early inflammatory response of electrode implantation is associated with symptom relief without electrical stimulation, but is negated by anti-inflammatory drugs. Early excitotoxic necrosis and subsequent glial scarring modulate the conductivity of the tissue-electrode interface, which can provide some detail into the inflammatory response of individual patients. The feasibility of this was demonstrated by measuring resistance values across a bipolar electrode which was unilaterally implanted into the nucleus accumbens of a rat while receiving continuous deep brain stimulation with a portable back-mounted device using clinical parameters (130Hz, 200μA, 90μs) for 3 days...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226377/applying-a-visual-assessment-tool-to-facial-linear-scars
#12
Lindsey K Collins, Thomas J Knackstedt, Pamela Ganger, Emily Scherer, Faramarz H Samie
Previous scar scales have focused on verbal descriptions. A nonverbal visual assessment tool would provide a simple way for patients and physicians to quantify scar appearance. The authors sought to use a validated visual assessment tool for linear surgical scars to assess linear scars on the face and to determine whether patients and surgeons rate scars similarly. A total of 143 patients with linear facial scars resulting from repair of Mohs micrographic surgery defects used the visual assessment tool to rate their surgical scar...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226374/adjuncts-to-improve-nasal-reconstruction-results
#13
Shayna Lee Gordon, Eva A Hurst
The final cosmetic appearance of nasal reconstruction scars is of paramount importance to both the patient and surgeon. Ideal postreconstruction nasal scars are flat and indistinguishable from surrounding skin. Unfortunately, even with meticulous surgical execution, nasal scars can occasionally be suboptimal. Abnormal fibroblast response can lead to hypertrophic nasal scars, and excessive angiogenesis may lead to telangiectasias or an erythematous scar. Imperfect surgical closure or poor postoperative management can lead to surgical outcomes with step-offs, depressions, suture marks, or dyspigmentation...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226366/principles-of-nasal-reconstruction
#14
Emily Spataro, Gregory H Branham
The rise in cutaneous malignancies over the past 20 years has led to significant advances in reconstructing the nose from an aesthetic and functional standpoint. The principles of nasal reconstruction center on application of the nasal subunit principle, three-layered reconstruction, nasal skin characteristics, and patient factors. Reconstructive planning starts with proper defect analysis, followed by application of the reconstructive ladder for soft-tissue repair, adequate structural support, and repair of nasal lining deficits...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28225918/the-aplication-of-cyanoacrilate-surgical-glue-on-skin-suture-in-rats
#15
João Ilgenfritz, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, João Ilgenfritz, Gerson Gattats Orro de Campos, Ricardo Kenithi Nakamura, Danilo M Zanello Guerisoli, Wilson de Barros Cantero
Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28224227/-exceptional-pacemaker-complication-in-still-s-disease
#16
Salma Haj Kheder, Thomas Hummel, Heike Majewski, Rafael Jimènez, Alexander Wutzler
CASE REPORT: A 49-year-old man with Still's disease presented with a rash above his pacemaker scar. In 2012, there was a replacement of the generator in which the position was changed from subpectoral to subcutaneous. A revision operation was performed after the local finding became worse, turning from a granuloma to a macula. THERAPY: During surgery, a superficial position of the leads was revealed. Both leads and generator were removed with great effort from the granulation tissue...
February 21, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28224209/-suture-techniques-and-material-in-surgery-of-flexor-tendons
#17
T Pillukat, R Fuhrmann, J Windolf, J van Schoonhoven
Adhesions and scar formation between flexor tendons and the surrounding tissue are only contemporarily avoidable by movement of flexor tendons. Concepts with active follow-up protocols are more favorable than passive mobilization. The main risks of flexor tendon repair are rupture of the tendon suture, insidious gap formation and resistance to tendon gliding within the tendon sheath. Currently, there is no consensus with respect to the optimal suture technique or suture material. Nevertheless, there are some principles worth paying attention to, such as using stronger suture material, blocking stitches, suture techniques with four or more strands as well as circular running sutures...
February 21, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28223982/mouse-model-of-neurological-complications-resulting-from-encephalitic-alphavirus-infection
#18
Shannon E Ronca, Jeanon Smith, Takaaki Koma, Magda M Miller, Nadezhda Yun, Kelly T Dineley, Slobodan Paessler
Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28223754/almost-unilateral-focal-dermal-hypoplasia
#19
Solam Lee, Sung Jay Choe, Sung Ku Ahn
Focal dermal hypoplasia, caused by mutations in PORCN, is an X-linked ectodermal dysplasia, also known as Goltz syndrome. Only seven cases of unilateral or almost unilateral focal dermal hypoplasia have been reported in the English literature and there have been no previously reported cases in the Republic of Korea. A 19-year-old female presented with scalp defects, skin lesions on the right leg and the right trunk, and syndactyly of the right fourth and fifth toes. Cutaneous examination revealed multiple atrophic plaques and a brown and yellow mass with fat herniation and telangiectasia that was mostly located on the lower right leg...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223486/serum-borne-bioactivity-caused-by-pulmonary-multiwalled-carbon-nanotubes-induces-neuroinflammation-via-blood-brain-barrier-impairment
#20
Mario J Aragon, Lauren Topper, Christina R Tyler, Bethany Sanchez, Katherine Zychowski, Tamara Young, Guy Herbert, Pamela Hall, Aaron Erdely, Tracy Eye, Lindsey Bishop, Samantha A Saunders, Pretal P Muldoon, Andrew K Ottens, Matthew J Campen
Pulmonary exposure to multiwalled carbon nanotubes (MWCNTs) causes indirect systemic inflammation through unknown pathways. MWCNTs translocate only minimally from the lungs into the systemic circulation, suggesting that extrapulmonary toxicity may be caused indirectly by lung-derived factors entering the circulation. To assess a role for MWCNT-induced circulating factors in driving neuroinflammatory outcomes, mice were acutely exposed to MWCNTs (10 or 40 µg/mouse) via oropharyngeal aspiration. At 4 h after MWCNT exposure, broad disruption of the blood-brain barrier (BBB) was observed across the capillary bed with the small molecule fluorescein, concomitant with reactive astrocytosis...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
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