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https://www.readbyqxmd.com/read/28095964/f-wave-duration-parameters-as-a-specific-and-sensitive-tool-for-diagnosis-of-restless-legs-syndrome
#1
Patrizia Congiu, Maria Livia Fantini, Giulia Milioli, Paolo Tacconi, Michela Figorilli, Gioia Gioi, Bruno Pereira, Francesco Marrosu, Liborio Parrino, Monica Puligheddu
STUDY OBJECTIVES: Restless legs syndrome, also known as Willis-Ekbom disease (RLS/WED), is a frequent condition, though its pathophysiology is not completely understood. The diagnosis of RLS/WED relies on clinical criteria, and the only instrumental tool, the suggested immobilization test, may lead to equivocal results. Recently, neurophysiological parameters related to F-wave duration have been proposed as a diagnostic aid. The aim of this study is to assess and compare the diagnostic values of these parameters in diagnosis of RLS/WED...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28065734/laparoscopic-roux-en-y-gastric-bypass-in-adolescents-with-severe-obesity-amos-a-prospective-5-year-swedish-nationwide-study
#2
Torsten Olbers, Andrew J Beamish, Eva Gronowitz, Carl-Erik Flodmark, Jovanna Dahlgren, Gustaf Bruze, Kerstin Ekbom, Peter Friberg, Gunnar Göthberg, Kajsa Järvholm, Jan Karlsson, Staffan Mårild, Martin Neovius, Markku Peltonen, Claude Marcus
BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservatively treated adolescents and of adults undergoing Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28045722/the-extraordinary-case-of-the-hungry-woman-large-foreign-body-ingestion-with-respiratory-arrest
#3
Lindsay L Warner, Dale C Ekbom, Paul A Warner
Repeated ingestion of small objects has been previously reported in the psychiatric literature. We recently had a patient with repeated intentional foreign body ingestion syndrome who developed complete airway obstruction and cardiac arrest after ingesting a computer mouse tracking ball. We use our case to suggest a pathway that can be used for similar emergent airway problems.
December 30, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27994356/a-double-blind-randomized-controlled-trial-to-compare-the-efficacy-and-tolerability-of-fixed-doses-of-ropinirole-bupropion-and-iron-in-treatment-of-restless-legs-syndrome-willis-ekbom-disease
#4
Kirti Vishwakarma, Juhi Kalra, Ravi Gupta, Mukesh Sharma, Taruna Sharma
BACKGROUND: We aimed to compare the efficacy of fixed doses of bupropion and ropinirole and iron alone for the treatment of restless legs syndrome (RLS) and to look for the tolerability of these medications. MATERIALS AND METHODS: Patients diagnosed with RLS were randomly divided into three groups with thirty patients in each group (Group A: Bupropion [300 mg/day], Group B: Ropinirole [0.25-0.5 mg/day], and Group C: Oral iron [150 mg elemental iron] along with folic acid [500 μg])...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27894926/special-issue-advances-in-scientific-understanding-of-the-restless-legs-syndrome-rls-aka-willis-ekbom-disease-wed-introduction-towards-a-better-understanding-of-the-science-of-rls-wed
#5
EDITORIAL
Diego Garcia Borreguero, Juliane Winkelman, Richard P Allen
No abstract text is available yet for this article.
October 28, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27891657/sleep-differences-in-one-year-old-children-were-related-to-obesity-risks-based-on-their-parents-weight-according-to-baseline-longitudinal-study-data
#6
Mirjam Ekstedt, Mojgan Haji Seyed Ebrahim Darkeh, Lijuan Xiu, Michaela Forssén, Elin Johansson, Anna Ek, Viktoria Svensson, Kerstin Ekbom, Claude Marcus
AIM: Parental obesity is the predominant risk factor for child obesity. We compared sleep in one-year-old children with different obesity risks, based on parental weight, and explored associations with weight, parental sleep and family factors. METHODS: Baseline data from 167 families participating in a longitudinal obesity prevention programme was used. Sleep patterns were compared between groups with high and low obesity risks, based on parental weight, and associations between child sleep and weight status, family obesity risk and parental sleep were explored...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27802358/risk-of-second-primary-cancer-in-patients-treated-with-radiotherapy-for-rectal-cancer
#7
A Martling, K E Smedby, H Birgisson, H Olsson, F Granath, A Ekbom, B Glimelius
BACKGROUND: Many patients with rectal cancer receive radiotherapy (RT) to reduce the risk of local recurrence. Radiation may give rise to adverse effects, including second primary cancers. In view of the divergent results of previous studies, the present study evaluated the risk of second primary cancer following RT in all randomized RT rectal cancer trials conducted in Sweden and in the Swedish ColoRectal Cancer Registry (SCRCR). METHODS: Patients included in five randomized trials and the SCRCR were linked to the Swedish Cancer Registry...
November 1, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27802156/recent-advances-in-clinical-practice-a-systematic-review-of-isolated-colonic-crohn-s-disease-the-third-ibd
#8
REVIEW
Sreedhar Subramanian, Anders Ekbom, Jonathan M Rhodes
The genetics of isolated colonic Crohn's disease place it approximately midway between Crohn's disease with small intestinal involvement and UC, making a case for considering it as a separate condition. We have therefore systematically reviewed its epidemiology, pathophysiology and treatment. Key findings include a higher incidence in females (65%) and older average age at presentation than Crohn's disease at other sites, a mucosa-associated microbiota between that found in ileal Crohn's disease and UC, no response to mesalazine, but possibly better response to antitumour necrosis factor than Crohn's disease at other sites...
February 2017: Gut
https://www.readbyqxmd.com/read/27773807/outcomes-of-pregnancies-for-women-undergoing-endoscopy-while-they-were-pregnant-a-nationwide-cohort-study
#9
Jonas F Ludvigsson, Benjamin Lebwohl, Anders Ekbom, Ravi P Kiran, Peter H R Green, Jonas Höijer, Olof Stephansson
BACKGROUND & AIMS: Endoscopy is an integral part of the investigation and management of gastrointestinal disease. We aimed to examine outcomes of pregnancies for women who underwent endoscopy during their pregnancy. METHODS: We performed a nationwide population-based cohort study, linking data from the Swedish Medical Birth Registry (for births from 1992 through 2011) with those from the Swedish Patient Registry. We identified 3052 pregnancies exposed to endoscopy (2025 upper endoscopies, 1109 lower endoscopies, and 58 endoscopic retrograde cholangiopancreatographies)...
October 20, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27765577/increased-rate-of-abdominal-surgery-both-before-and-after-diagnosis-of-celiac-disease
#10
Matthew Kurien, David S Sanders, Anders Ekbom, Carolina Ciacci, Jonas F Ludvigsson
BACKGROUND: The detection of celiac disease (CD) is suboptimal. AIMS: We hypothesized that misdiagnosis is leading to diagnostic delays, and examine this assertion by determining if patients have increased risk of abdominal surgery before CD diagnosis. METHODS: Through biopsy reports from Sweden's 28 pathology departments we identified all individuals with CD (Marsh stage 3; n=29,096). Using hospital-based data on inpatient and outpatient surgery recorded in the Swedish Patient Register, we compared abdominal surgery (appendectomy, laparotomy, biliary tract surgery, and uterine surgery) with that in 144,522 controls matched for age, sex, county and calendar year...
September 26, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27725646/oral-contraceptive-use-and-risk-of-ulcerative-colitis-progression-a-nationwide-study
#11
Hamed Khalili, Martin Neovius, Anders Ekbom, Jonas F Ludvigsson, Johan Askling, Andrew T Chan, Ola Olen
OBJECTIVES: Oral contraceptive (OC) use has been consistently linked to increased risk of inflammatory bowel disease. Nonetheless, a specific role of OC in the natural history of ulcerative colitis (UC) is unknown. METHODS: We identified 6,104 incident female UC cases aged 16-51 years at diagnosis from the Swedish National Patient Register starting in January of 2003. Information on current OC use was obtained from the Prescribed Drug Register starting in July of 2005...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27701386/reproductive-history-and-risk-of-colorectal-adenocarcinoma-in-parous-women-a-nordic-population-based-case-control-study
#12
Tone Bjørge, Mika Gissler, Anne Gulbech Ording, Anders Engeland, Ingrid Glimelius, Maarit Leinonen, Henrik Toft Sørensen, Steinar Tretli, Anders Ekbom, Rebecca Troisi, Tom Grotmol
BACKGROUND: Data are conflicting regarding the role of endogenous sex hormones in colorectal carcinogenesis. In this large population-based study, we pooled data from birth and cancer registries in four Nordic countries, to evaluate the risk of colorectal adenocarcinoma in relation to women's reproductive history. METHODS: We conducted a population-based case-control study among women registered in Nordic birth registries. The study included colorectal adenocarcinoma cases diagnosed in Denmark, Finland, Norway, and Sweden during 1967-2013 and up to 10 matched controls per case, in total 22 185 cases and 220 246 controls...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27692278/default-mode-network-disturbances-in-restless-legs-syndrome-willis-ekbom-disease
#13
Jeonghun Ku, Yeong Seon Lee, HyukWon Chang, Christopher J Earley, Richard P Allen, Yong Won Cho
BACKGROUND: The unusual sensations of restless legs syndrome/Willis-Ekbom disease (RLS/WED) are induced by rest or a low arousal state with a circadian variation in the threshold for induction. It has been suggested that the emergence of RLS/WED symptoms relates to abnormal brain functions dealing with internally generated stimuli. The purpose of this study was to investigate the changes in the default mode network (DMN) in RLS/WED subjects. METHODS: Sixteen drug-naïve, idiopathic, RLS/WED subjects, and 16 age-matched and gender-matched healthy subjects were scanned in an asymptomatic resting state...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27662970/association-between-the-neutrophil-to-lymphocyte-ratio-a-new-marker-of-systemic-inflammation-and-restless-legs-syndrome
#14
Ceyhun Varım, Bilgehan Atılgan Acar, Mehmet Sevki Uyanık, Turkan Acar, Neslihan Alagoz, Ahmet Nalbant, Tezcan Kaya, Hasan Ergenc
INTRODUCTION: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR. METHODS: A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study...
September 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27642468/-nosographic-considerations-on-delusional-parasitosis-based-on-three-clinical-observations
#15
Nabil Berhili, Amine Bout, Hayat Hlal, Chadya Aarab, Rachid Aalouane, Ismail Rammouz
Ekbom syndrome or delusional parasitosis is a rare disease characterized by the unwavering conviction of having cutaneous infestation of insects or parasites. This is a monothematic delusion of hallucinatory origin that typically affects older women. We report the case of three patients with delusional parasitosis in different clinical settings. The first patient suffered from isolated delusional parasitosis corresponding to the condition described by Karl Ekbom. The second case suffered from secondary delusional parasitosis, occurring in the setting of leukoencephalopathy (CADASIL)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27578401/histologic-evaluation-of-micronized-alloderm-after-injection-laryngoplasty-in-a-rabbit-model
#16
Michael S Oldenburg, Jeff Janus, Steve Voss, Serban San Marina, Tiffany Chen, Joaquin Garcia, Dale Ekbom
OBJECTIVES/HYPOTHESIS: Micronized AlloDerm is a commonly used injectable material for injection laryngoplasty; however, the histologic response to laryngeal implantation and resorption rate over time have not been elucidated. This study aimed to evaluate the in vivo response of micronized AlloDerm over time after laryngeal implantation using a rabbit model. STUDY DESIGN: Animal model. METHODS: The left recurrent laryngeal nerve was sectioned in five New Zealand White rabbits to create a vocal cord paralysis...
August 31, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27548712/association-between-impaired-fasting-glycaemia-in-pediatric-obesity-and-type-2-diabetes-in-young-adulthood
#17
E Hagman, P Danielsson, L Brandt, A Ekbom, C Marcus
OBJECTIVES: In adults, impaired fasting glycemia (IFG) increases the risk for type 2 diabetes mellitus (T2DM). This study aimed to investigate to which extent children with obesity develop T2DM during early adulthood, and to determine whether IFG and elevated hemoglobin A1c (HbA1c) in obese children are risk markers for early development of T2DM. METHODS: In this prospective cohort study, 1620 subjects from the Swedish Childhood Obesity Treatment Registry - BORIS who were ⩾18 years at follow-up and 8046 individuals in a population-based comparison group, matched on gender age and living area, were included...
2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27522437/treatment-of-oropharyngeal-dysphagia-secondary-to-idiopathic-cricopharyngeal-bar-surgical-cricopharyngeal-muscle-myotomy-versus-dilation
#18
Alexander P Marston, Francisco J Maldonado, Karthik Ravi, Jan L Kasperbauer, Dale C Ekbom
OBJECTIVE: To compare swallowing outcomes following cricopharyngeal (CP) dilation versus surgical myotomy in patients with dysphagia secondary to idiopathic CP bar. METHODS: All patients had an idiopathic CP bar without a history of Zenker's diverticulum, head and neck cancer, or systemic neurologic disease treated between 2000 and 2013. The Functional Outcome Swallowing Scale (FOSS) was utilized to assess dysphagia symptoms. RESULTS: Twenty-three patients underwent 46 dilations and 20 patients had a myotomy...
November 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27512466/restless-leg-syndrome-in-pregnancy
#19
REVIEW
Aarti Grover, Courtney Clark-Bilodeau, Carolyn M D'Ambrosio
Restless leg syndrome, more recently renamed Willis-Ekbom disease, is a condition that disrupts sleep and occurs more frequently in the pregnant population. We present a 39-year-old woman with restless legs syndrome in the third trimester and discuss the epidemiology, pathophysiology and therapeutic options in the pregnant population while highlighting the challenges posed by the lack of safety data of approved drugs.
September 2015: Obstetric Medicine
https://www.readbyqxmd.com/read/27496946/vitamin-d-deficiency-and-low-ionized-calcium-are-linked-with-semen-quality-and-sex-steroid-levels-in-infertile-men
#20
Martin Blomberg Jensen, Jacob Gerner Lawaetz, Anna-Maria Andersson, Jørgen Holm Petersen, Loa Nordkap, Anne Kirstine Bang, Pia Ekbom, Ulla Nordström Joensen, Lisbeth Prætorius, Peter Lundstrøm, Vibeke Hartvig Boujida, Beate Lanske, Anders Juul, Niels Jørgensen
STUDY QUESTION: Are low vitamin D levels linked with semen quality and sex steroids in infertile men? SUMMARY ANSWER: Infertile men with vitamin D deficiency had lower sperm motility, total numbers of motile sperm, Inhibin B, sex-hormone-binding-globulin (SHBG) and testosterone/estradiol ratio, but higher levels of free sex steroids, than infertile men with normal vitamin D levels. WHAT IS KNOWN ALREADY: Low vitamin D levels have been associated with decreased sperm motility in healthy men, but a relationship between vitamin D and calcium with semen quality and especially sex steroids has not been sufficiently described in infertile men...
August 2016: Human Reproduction
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