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https://www.readbyqxmd.com/read/28531871/echinococcosis-mimicking-liver-malignancy-a-case-report
#1
Radek Pohnan, Miroslav Ryska, Vladislav Hytych, Radek Matej, Petr Hrabal, Jiri Pudil
INTRODUCTION: Human Alveolar Echinococcosis - Alveolar Hydatid disease (AE) is an omitted zoonotic infection presenting with focal liver lesions. Cause of AE is a larval stage of Echinococcus multilocularis tapeworms. CASE PRESENTATION: In this report an extraordinary case of a 38 year-old female examined due to 2 liver tumors and 2 pulmonary nodules is described. The patient underwent pulmonary and liver surgery for suspected advanced cholangiocellular carcinoma and surprisingly AE was found...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28530073/-red-herring-complaints-in-an-eighteen-years-old-female-with-a-hydatid-cyst-of-the-lung
#2
Nasser Nadim
Brain and eye hydatid cysts are early symptomatic, as opposed to those developing in other organs, including lungs, where they remain asymptomatic through adolescence, even to adulthood, due to their slow growth. Hence, discovering that patients have lung hydatid cyst occurs, frequently, during random chest imaging. Up to thirty percent of pulmonary echinococcal cysts may rupture spontaneously, after chest or abdominal trauma. The main lung hydatidosis complaints, such as dyspnea and chest pain, are caused by the reduction of the functional area of the lung, expectoration of the tapeworm cystoides into the bronchial tree, or by compression of surrounding structures...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529629/the-antihelminthic-drug-niclosamide-effectively-inhibits-the-malignant-phenotypes-of-uveal-melanoma-in-vitro-and-in-vivo
#3
Jingfeng Zhou, Bei Jin, Yanli Jin, Yizhi Liu, Jingxuan Pan
Uveal melanoma (UM) is a lethal intraocular malignancy with an average survival of only 2~8 months in patients with hepatic metastasis. Currently, there is no effective therapy for metastatic UM. Here, we reported that niclosamide, an effective repellence of tapeworm that has been approved for use in patients for approximately 50 years, exhibited strong antitumor activity in UM cells in vitro and in vivo. We showed that niclosamide potently inhibited UM cell proliferation, induced apoptosis and reduced migration and invasion...
2017: Theranostics
https://www.readbyqxmd.com/read/28528580/update-on-the-distribution-of-the-co-invasive-schyzocotyle-acheilognathi-bothriocephalus-acheilognathi-the-asian-fish-tapeworm-in-freshwater-fishes-of-mexico
#4
G Pérez-Ponce de León, O Lagunas-Calvo, L García-Prieto, R Briosio-Aguilar, R Aguilar-Aguilar
The Asian fish tapeworm, Schyzocotyle acheilognathi (syn. Bothriocephalus acheilognathi) represents a threat to freshwater fish, mainly cyprinids, across the globe. This tapeworm possesses an extraordinary ability to adapt to different environmental conditions and, because of that, from its natural geographical origin in mainland Asia, it has colonized every continent except Antarctica. It is thought that this pathogenic tapeworm was first co-introduced into Mexico in 1965 from China, with the grass carp Ctenopharyngodon idella, although the first formal record of its presence was published in 1981...
May 22, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28526606/identification-of-emsox2-a-member-of-the-sox-family-of-transcription-factors-as-a-potential-regulator-of-echinococcus-multilocularis-germinative-cells
#5
Zhe Cheng, Fan Liu, Mengya Dai, Jianjian Wu, Xiu Li, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang
Larvae of the tapeworm Echinococcus multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. The germinative cells, a population of stem cell-like cells, are considered to drive the continuous growth of the metacestodes within the host. The mechanisms and relative molecules controlling the behavior of germinative cells are poorly understood. Sox transcription factors play important roles in maintenance and regulation of stem/progenitor cells. We here describe the identification of a Sox family member in E...
May 17, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28520724/development-of-a-movement-based-in-vitro-screening-assay-for-the-identification-of-new-anti-cestodal-compounds
#6
Dominic Ritler, Reto Rufener, Heinz Sager, Jacques Bouvier, Andrew Hemphill, Britta Lundström-Stadelmann
Intestinal cestodes are infecting millions of people and livestock worldwide, but treatment is mainly based on one drug: praziquantel. The identification of new anti-cestodal compounds is hampered by the lack of suitable screening assays. It is difficult, or even impossible, to evaluate drugs against adult cestodes in vitro due to the fact that these parasites cannot be cultured in microwell plates, and adult and larval stages in most cases represent different organisms in terms of size, morphology, and metabolic requirements...
May 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28497745/preventive-efficacy-of-nexgard-spectra-%C3%A2-against-dipylidium-caninum-infection-in-dogs-using-a-natural-flea-ctenocephalides-felis-infestation-model
#7
Frédéric Beugnet, Leon Meyer, Josephus Fourie, Diane Larsen
The efficacy of a monthly oral endectocide product, NexGard Spectra(®) (Merial), a combination of afoxolaner and milbemycin oxime, was evaluated in a flea (Ctenocephalides felis) challenge model for the prevention of Dipylidium caninum tapeworm infection in dogs. The efficacy of treatment with NexGard Spectra(®) was assessed in 10 dogs following weekly flea infestation with metacestode naturally infected fleas and compared with that in 10 untreated control dogs. The 100 fleas deposited weekly on each dog were not removed until Day 35, allowing enough time for their ingestion...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28493801/imaging-of-hydatid-disease-with-a-focus-on-extrahepatic-involvement
#8
Eugenio Zalaquett, Christine Menias, Francisco Garrido, Matías Vargas, José Francisco Olivares, Daniel Campos, Natalia Pinochet, Antonio Luna, Nirvikar Dahiya, Álvaro Huete
Hydatid disease (HD) is a parasitic infection caused by the larvae of a tapeworm that is endemic to many regions around the world-South America, Africa, and Asia, in particular. Humans are infected as intermediate hosts in the parasite's life cycle; thus, HD can be seen in persons living in areas where animal husbandry is practiced. However, owing to the varied patterns of migration and immigration during the past several decades, HD can be diagnosed in individuals living anywhere. The liver is the most common organ involved, with hepatic HD accounting for the majority of published cases...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28467600/recent-advancements-and-new-perspectives-in-animal-models-for-neurocysticercosis-immunopathogenesis
#9
REVIEW
N Arora, S Tripathi, P Kumar, P Mondal, A Mishra, A Prasad
Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human), and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies...
May 3, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28462423/design-and-validation-of-a-biosensor-implantation-capsule-robot
#10
Wanchuan Xie, Weston M Lewis, Jared Kaser, C Ross Welch, Pengbo Li, Carl A Nelson, Vishal Kothari, Benjamin S Terry
We have proposed a long-term, non-invasive, non-restrictive method of delivering and implanting a biosensor within the body via a swallowable implantation capsule robot (ICR). The design and preliminary validation of the ICR's primary subsystem-the sensor deployment system-is discussed and evidence is provided for major design choices. The purpose of the sensor deployment system is to adhere a small biosensor to the mucosa of the intestine long-term, and the modality was inspired by tapeworms and other organisms that employ a strategy of mechanical adhesion to soft tissue via the combined use of hooks or needles and suckers...
May 2, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28457048/asymptomatic-presentation-of-large-cardiac-hydatid
#11
Amey Beedkar, Rohan Parikh, Pradeep Deshmukh
Hydatid cyst is a tissue parasitic infection caused by tapeworm Echinococcus granulosus. Common location for hydatid cysts are the liver (65%) and the lungs (25%). Cardiac hydatid cyst is seen rarely, occurring in about 0.5-2% of all cases of hydatid disease. We present this case of 45 years female who presented with short duration of dry cough and atypical chest pain. Chest X ray showed cardiomegaly with round bulge at the right heart border and curvilinear calcification in left upper abdomen in the region of spleen...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28456662/new-mitogenome-and-nuclear-evidence-on-the-phylogeny-and-taxonomy-of-the-highly-zoonotic-tapeworm-echinococcus-granulosus-sensu-stricto
#12
Liina Kinkar, Teivi Laurimäe, Mitra Sharbatkhori, Hossein Mirhendi, Eshrat Beigom Kia, Francisco Ponce-Gordo, Vanessa Andresiuk, Sami Simsek, Antti Lavikainen, Malik Irshadullah, Gérald Umhang, Myriam Oudni-M'rad, Gerardo Acosta-Jamett, Steffen Rehbein, Urmas Saarma
Cystic echinococcosis, a zoonotic disease caused by Echinococcus granulosus sensu lato (s. l.), is a significant global public health concern. Echinococcus granulosus s. l. is currently divided into numerous genotypes (G1-G8 and G10) of which G1-G3 are the most frequently implicated genotypes in human infections. Although it has been suggested that G1-G3 could be regarded as a distinct species E. granulosus sensu stricto (s. s.), the evidence to support this is inconclusive. Most importantly, data from nuclear DNA that provide means to investigate the exchange of genetic material between G1-G3 is lacking as none of the published nuclear DNA studies have explicitly included G2 or G3...
April 27, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28452686/helminths-and-intestinal-barrier-function
#13
Derek M McKay, Adam Shute, Fernando Lopes
Approximately one-sixth of the worlds' population is infected with helminths and this class of parasite takes a major toll on domestic livestock. The majority of species of parasitic helminth that infect mammals live in the gut (the only niche for tapeworms) where they contact the hosts' epithelial cells. Here, the helminth-intestinal epithelial interface is reviewed in terms of the impact on, and regulation of epithelial barrier function, both intrinsic (epithelial permeability) and extrinsic (mucin, bacterial peptides, commensal bacteria) elements of the barrier...
January 2, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/28448863/multi-sited-hydatid-cystic-disease-with-muscular-involvement-in-a-young-female-a-case-report-from-syria
#14
Hazem Aljasem, Mohammad Almess, Monzer Bakgagi
INTRODUCTION: Hydatidosis is a unique disease caused by a tapeworm called Echinococcus granulosus. Musculoskeletal involvement with hydatid cystic disease accounts for less than 5% of all cases. The main purpose of this study is to present a case of multi-sited hydatid cystic disease and how to manage it. PRESENTATION OF CASE: Here we present a case of 14-year-old girl complained of a gradually enlarging mass on her left shoulder with a final diagnosis of triple-sited hydatid cystic disease including the right lung, the left trapezius muscle and the liver...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28440965/concurrent-pulmonary-sequestration-and-pulmonary-hydatid-cyst-in-a-child-a-case-report
#15
Dawood Yusef, Shadi Hamouri, Yousef Odeh
Pulmonary sequestration (PS) happens when an area of the lung receives its arterial blood supply from systemic circulation, resulting in a non-functional lesion (Intralobar or extralobar). Hydatid cyst results from infection of the tapeworm Echinococcus. We report a case of hydatid cyst existed concurrently with intralobar PS. A 12-year-old girl presented with recurrent hemoptysis of 2 years duration. Serology for Echinococcus granulosus was positive. CT chest suggested intralobar PS in the right middle lobe, which was surgically removed...
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28433562/characterization-of-the-complete-mitochondrial-genome-of-khawia-sinensis-belongs-among-platyhelminths-cestodes
#16
Yan Feng, Han-Li Feng, Yi-Hui Fang, Ying-Bing Su
Khawia sinensis is an important species in freshwater fish causing considerable economic losses to the breeding industry. This is the first mt genome of a caryophyllidean cestode characterised. The entire mt genome of K. sinensis is 13,759 bp in length. This mt genome contains 12 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes and two non-coding regions. The arrangement of the K. sinensis mt genome is the same as other tapeworms, however, the incomplete stop codon (A) is more frequent that other species...
April 20, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28426415/detection-of-echinococcus-multilocularis-dna-in-fruit-vegetable-and-mushroom-samples-collected-in-the-non-endemic-territory-of-the-pomerania-province-and-comparison-of-the-results-with-data-from-rural-areas-of-the-neighbouring-highly-endemic-warmia-masuria
#17
Anna Lass, Beata Szostakowska, Przemyslaw Myjak, Krzysztof Korzeniewski
Echinococcus multilocularis is a tapeworm that may cause alveolar echinococcosis (AE), one of the most dangerous parasitic zoonoses. As in the case of some foodborne diseases, unwashed fruits and vegetables contaminated with eggs of E. multilocularis may serve as an important transmission route for this parasite. The aim of this study was to investigate the presence of E. multilocularis DNA in fruit, vegetables, and mushrooms in rural areas of the Pomerania province, Poland (non-endemic territory). In total, 104 environmental fruit, vegetable, and mushroom samples collected in forests, plantations, and kitchen gardens were analysed using nested PCR based on the mitochondrial 12S rRNA gene...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426409/a-new-species-of-oochoristica-cyclophyllidea-linstowiidae-from-non-native-mediterranean-geckos-hemidactylus-turcicus-sauria-gekkonidae-from-texas-usa
#18
Chris T McAllister, Charles R Bursey
A new species of cyclophyllidean tapeworm, Oochoristica harschi sp. nov. is described from 2 of 18 (11%) non-native Mediterranean geckos (Hemidactylus turcicus) collected in June 2016 from Tom Green County, Texas, USA The new species has few characteristics in common with 17 species of Oochoristica previously described from Nearctic reptiles. Of this group, O. harschi is most similar to O. macallisteri Bursey and Goldberg, 1996 from the side-blotched lizard, Uta stansburiana from Arizona and California, USA, in number of testes, 14-20 vs...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28426407/helminth-cestoda-nematoda-and-coccidian-apicomplexa-eimeriidae-parasites-of-the-eastern-small-footed-myotis-myotis-leibii-chiroptera-vespertilionidae-from-arkansas-with-a-description-of-a-new-species-of-eimeria
#19
Chris T McAllister, R Scott Seville, Charles R Bursey
During May and July 2016, 32 eastern small-footed myotis (Myotis leibii) were collected from five counties of northwestern Arkansas and their faeces examined for coccidian parasites. Four of 32 (13%) M. leibii harboured an eimerian that we describe here as new. Oocysts of Eimeria sassei sp. n. were ovoidal to ellipsoidal with a bi-layered wall and measured (length × width, L × W) 18.3 × 15.2 µm, with an L/W ratio of 1.2. A micropyle and oocyst residuum were absent but 1-2 polar granules were present. Sporocysts were ovoidal, 9...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28424102/gaining-insights-into-the-ecological-role-of-the-new-zealand-sole-peltorhamphus-novaezeelandiae-through-parasites
#20
T Anglade, H S Randhawa
Despite the fact that tapeworms comprise the bulk of parasite communities of sharks in marine ecosystems, little is known about their life cycles and, more specifically, about the potential intermediate hosts they utilize as transmission routes. In the absence of morphological features required for specific identification of larval tapeworms from potential intermediate hosts, recent molecular advances have contributed to linking larval and adult parasites and, in some instances, uncovering unknown trophic links...
April 20, 2017: Journal of Helminthology
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