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https://www.readbyqxmd.com/read/29440657/nippostrongylus-brasiliensis-infection-leads-to-impaired-reference-memory-and-myeloid-cell-interference
#1
T M Brombacher, K S De Gouveia, L Cruywagen, N Makena, F Booley, O Tamgue, F Brombacher
Hookworm infection is endemic in developing countries, leading to poor cognitive function-among other disruptions. In this study, the effects of Nippostrongylus brasiliensis infection (a murine model of Necator Americanus) on cognitive function were investigated. Though impaired cognition has been extensively reported, the exact domain of cognition affected is still unknown, hence requiring investigation. The objective of this study was to identify possible cognitive changes during Nippostrongylus brasiliensis infection in mice, using the Morris water maze...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428963/efficacy-of-strain-elastography-in-diagnosis-and-staging-of-acute-appendicitis-in-pediatric-patients
#2
Harun Arslan, Zülküf Akdemir, Alpaslan Yavuz, Fahri Gökçal, Cemal Parlakgümüş, Necat İslamoglu, Hüseyin Akdeniz
BACKGROUND In the present study, the role and efficiency of strain elastography (SE) were evaluated in diagnosis and staging of acute appendicitis in pediatric patients. MATERIAL AND METHODS We enrolled 225 pediatric patients with suspected clinical and laboratory findings of acute appendicitis. Gray-scale sonographic findings were recorded and staging was made by the colorization method of SE imaging. Appendectomy was performed in all patients and the results of the surgical pathology were compared with the imaging findings...
February 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29411502/draft-genome-and-description-of-novimethylophilus-kurashikiensis-gen-nov-sp-nov-a-new-lanthanide-dependent-methylotrophic-species-of-methylophilaceae
#3
Haoxin Lv, Nurettin Sahin, Akio Tani
Recently it has been found that two types of methanol dehydrogenases (MDHs) exist in Gram-negative bacterial methylotrophs, calcium-dependent MxaFI-MDH and lanthanide-dependent XoxF-MDH, and the latter is more widespread in bacterial genomes. We aimed to isolate and characterize lanthanide dependent methylotrophs. The growth of strain La2-4T on methanol, which was isolated from rice rhizosphere soil, was strictly lanthanide dependent. Its 16S rRNA gene sequence showed only 93.4% identity to that of Methylophilus luteus MimT , and the name Novimethylophilus kurashikiensis gen...
February 6, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29410653/the-risk-of-chronic-gastrointestinal-disorders-following-acute-infection-with-intestinal-parasites
#4
Jason Blitz, Mark S Riddle, Chad K Porter
Background: Infectious gastroenteritis (IGE) is caused by numerous bacterial, viral, and parasitic pathogens. A history of IGE has been shown in previous studies to increase the risk of developing chronic gastrointestinal disorders and other chronic conditions. As bacteria and viruses represent the majority of pathogen-specific causes of IGE, post-infectious studies have primarily focused on these organisms. The objective of this study was to investigate an association between a history of parasite-associated IGE and the subsequent development of chronic post-infectious gastrointestinal and non-gastrointestinal disorders in a military population...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29408394/production-and-optimization-of-polyhydroxyalkanoates-from-non-edible-calophyllum-inophyllum-oil-using-cupriavidus-necator
#5
A Arumugam, S G Senthamizhan, V Ponnusami, S Sudalai
Polyhydroxyalkanoates (PHA) are biodegradable polymers found in the cellular masses of a wide range of bacterial species and the demand for PHA is steadily growing. In this work we have produced PHA from a low-cost substrate, Calophyllum inophyllum oil, using Cupriavidus necator. Effects of various process parameters such as Oil concentration, Nitrogen source and inoculum size on the production of PHA were studied using Response Surface Methodology. A quadratic equation was used in the model to fit the experimental data...
February 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29399749/should-the-macular-lesions-around-spinal-dysraphism-be-excised-analysis-of-macular-lesions-accompanying-spinal-dysraphism
#6
Necmettin Tutuncu, Goktekin Tenekeci, Sakir Unal, Necat Yilmaz, Celal Bagdatoglu
AIM: Whether the macular lesions associated with spinal dysraphism should be preserved is controversial. This area is usually excised during reconstruction. This study aims to characterize the macular lesions associated with spinal dysraphism and to determine the outcomes of cases in which macular lesions are not excised. MATERIAL AND METHODS: The patient cohort comprised 17 patients with spinal dysraphism who were treated at Mersin University Hospital from 2005 through 2007...
December 17, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29370166/expanding-molecular-diagnostics-of-helminthiasis-piloting-use-of-the-gpln-platform-for-surveillance-of-soil-transmitted-helminthiasis-and-schistosomiasis-in-ghana
#7
Lucas J Cunningham, John Odoom, Deborah Pratt, Linda Boatemaa, Nana Asante-Ntim, Keren Attiku, Bismarck Banahene, Mike Osei-Atweneboana, Jaco J Verweij, David Molyneux, Russell J Stothard, Emily R Adams
The efforts to control and eradicate polio as a global health burden have been successful to the point where currently only three countries now report endemic polio, and the number of cases of polio continues to decrease. The success of the polio programme has been dependant on a well-developed network of laboratories termed the global polio laboratory network (GPLN). Here we explore collaborative opportunities with the GPLN to target two of the 18 diseases listed as a neglected tropical diseases (NTD) namely soil transmitted helminthiasis (STH) and Schistosomiasis (SCH)...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29356991/detection-and-analysis-of-mycovirus-related-rna-viruses-from-grape-powdery-mildew-fungus-erysiphe-necator
#8
B Pandey, R A Naidu, G G Grove
The fungus, Erysiphe necator Schw., is an important plant pathogen causing powdery mildew disease in grapevines worldwide. In this study, high-throughput sequencing of double-stranded RNA extracted from the fungal tissue combined with bioinformatics was used to examine mycovirus-related sequences associated with E. necator. The results showed the presence of eight mycovirus-related sequences. Five of these sequences representing three new mycoviruses showed alignment with sequences of viruses classified in the genus Alphapartitivirus in the family Partitiviridae...
January 22, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29349494/light-scattering-on-pha-granules-protects-bacterial-cells-against-the-harmful-effects-of-uv-radiation
#9
Eva Slaninova, Petr Sedlacek, Filip Mravec, Lucie Mullerova, Ota Samek, Martin Koller, Ondrej Hesko, Dan Kucera, Ivana Marova, Stanislav Obruca
Numerous prokaryotes accumulate polyhydroxyalkanoates (PHA) in the form of intracellular granules. The primary function of PHA is the storage of carbon and energy. Nevertheless, there are numerous reports that the presence of PHA granules in microbial cells enhances their stress resistance and fitness when exposed to various stress factors. In this work, we studied the protective mechanism of PHA granules against UV irradiation employing Cupriavidus necator as a model bacterial strain. The PHA-accumulating wild type strain showed substantially higher UV radiation resistance than the PHA non-accumulating mutant...
January 19, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29329945/model-of-acetic-acid-affected-growth-and-poly-3-hydroxybutyrate-production-by-cupriavidus-necator-dsm-545
#10
Jaruwan Marudkla, Wen-Chien Lee, Siwaporn Wannawilai, Yusuf Chisti, Sarote Sirisansaneeyakul
Acetic acid, a potential growth inhibitor, commonly occurs in lignocellulosic hydrolysates. The growth of Cupriavidus necator DSM 545 and production of poly(3-hydroxybutyrate) (PHB) by this bacterium in a glucose-based medium supplemented with various initial concentrations of acetic acid are reported. The bacterium could use both glucose and acetic acid to grow and produce PHB, but acetic acid inhibited growth once its initial concentration exceeded 0.5 g/L. As acetic acid is an unavoidable contaminant in hydrolysates used as sugar sources in commercial fermentations, a mathematical model was developed to describe its impact on growth and the production of PHB...
January 9, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29323785/crystal-structure-of-the-dna-binding-domain-of-the-lysr-type-transcriptional-regulator-cbnr-in-complex-with-a-dna-fragment-of-the-recognition-binding-site-in-the-promoter-region
#11
Maharani Pertiwi Koentjoro, Naruhiko Adachi, Miki Senda, Naoto Ogawa, Toshiya Senda
LysR-type transcriptional regulators (LTTRs) are among the most abundant transcriptional regulators in bacteria. CbnR is an LTTR derived from Cupriavidus necator (formerly Alcaligenes eutrophus or Ralstonia eutropha) NH9 and is involved in transcriptional activation of the cbnABCD genes encoding chlorocatechol degradative enzymes. CbnR interacts with a cbnA promoter region of approximately 60 bp in length that contains the recognition binding site (RBS) and activation binding site (ABS). Upon inducer binding, CbnR seems to undergo conformational changes, leading to activation of the transcription...
January 11, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29298972/human-papilloma-viruses-and-their-genotype-distribution-in-women-with-high-socioeconomic-status-in-central-anatolia-turkey-a-pilot-study
#12
Mert Ulaş Barut, Engin Yildirim, Mehmet Kahraman, Murat Bozkurt, Necat Imirzalioğlu, Ayhan Kubar, Eray Çalişkan, Sibel Sak, Tarık Aksu
BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients with unhealthy cervix in the study were: erosion, chronic cervicitis, healed lacerations, hypertrophied cervix, and abnormal discharges from the cervix...
January 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29261231/the-study-of-host-immune-responses-elicited-by-the-model-murine-hookworms-nippostrongylus-brasiliensis-and-heligmosomoides-polygyrus
#13
T Bouchery, B Volpe, K Shah, L Lebon, K Filbey, G LeGros, N Harris
Hookworm infections (Necator americanus or Ancylostoma duodenale) represent a major neglected tropical disease, affecting approximately 700 million people worldwide, and can cause severe morbidity due to the need for these worms to feed on host blood. N. brasiliensis and H. polygrus, both rodent parasites, are the two most commonly employed laboratory models of experimental hookworm infection. Both parasites evoke type 2 immune responses, and their use has been instrumental in generating fundamental insight into the molecular mechanisms of type-2 immunity and for understanding how the immune response can control parasite numbers...
December 20, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/29249918/sphenoethmoid-cell-the-battle-for-places-inside-of-the-nose-between-a-posterior-ethmoid-cell-and-sphenoid-sinus-3d-volumetric-quantification
#14
Mehmet Senturk, Ibrahim Guler, Isa Azgin, Engin Umut Sakarya, Ramazan Ocal, Betul Agirgol, Necat Alatas, Ismet Tolu, Mehmet Kilinc
Background: Sphenoethmoid cells may be above the sphenoid sinus with/ or without con-tact to optical nerve. Although sphenoethmoid cells are theoretically considered to possibly influence the sphenoid sinus volume, we could not find any study in the literature on this issue. Aims: The aim of our study was to detect sphenoethmoid cells and measure the sphenoid sinus vol-ume using multiplanar computerized tomography and also investigate the correlation between the presence of sphenoethmoid cells and the sphenoid sinus volume...
November 2017: Current Medical Imaging Reviews
https://www.readbyqxmd.com/read/29238275/13c-assisted-metabolic-flux-analysis-to-investigate-heterotrophic-and-mixotrophic-metabolism-in-cupriavidus-necator-h16
#15
Swathi Alagesan, Nigel P Minton, Naglis Malys
Introduction: Cupriavidus necator H16 is a gram-negative bacterium, capable of lithoautotrophic growth by utilizing hydrogen as an energy source and fixing carbon dioxide (CO2) through Calvin-Benson-Bassham (CBB) cycle. The potential to utilize synthesis gas (Syngas) and the prospects of rerouting carbon from polyhydroxybutyrate synthesis to value-added compounds makes C. necator an excellent chassis for industrial application. Objectives: In the context of lack of sufficient quantitative information of the metabolic pathways and to advance in rational metabolic engineering for optimized product synthesis in C...
2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29232490/co2-to-terpenes-autotrophic-and-electroautotrophic-%C3%AE-humulene-production-with-cupriavidus-necator
#16
Thomas Krieg, Anne Sydow, Sonja Faust, Ina Huth, Dirk Holtmann
Herein, we demonstrate that CO2 can be converted by an engineered "Knallgas" bacterium (Cupriavidus necator) to the terpene α-humulene. Heterologous expression of the mevalonate pathway and α-humulene synthase resulted in a production of approx. 10 mg α-humulene per gram cell dry mass (CDM) under heterotrophic conditions. This first example of chemolithoautotrophic production of a terpene from carbon dioxide, hydrogen and oxygen is a promising starting point for the production of different high value terpene compounds from abundant and simple raw materials...
December 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29217186/biosynthesis-of-silver-nanoparticles-and-polyhydroxybutyrate-nanocomposites-of-interest-in-antimicrobial-applications
#17
J L Castro-Mayorga, F Freitas, M A M Reis, M A Prieto, J M Lagaron
This study deals with the optimization and scaling up of the production of poly(3-hydroxybutyrate), PHB, nanocomposites containing biosynthesized silver nanoparticles (AgNPs) to generate materials with antimicrobial performance. First, a comparative study of the chemical and biological synthesis of AgNPs during the fermentation process of Cupriavidus necator at shake flask-scale was carried out. These experiments demonstrated the inherent capacity of C. necator to reduce the silver salt and produce AgNPs without the need for adding a reducing agent and, that the method of synthesis (with or without reducing agent) affects the dispersion of the AgNPs and their antimicrobial performance...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29216182/the-physicochemical-fingerprint-of-necator-americanus
#18
Veeren M Chauhan, David J Scurr, Thomas Christie, Gary Telford, Jonathan W Aylott, David I Pritchard
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3) to the intestinal tract (L4 maturing to adult). It has been hypothesised that the L3 larval sheath, which is shed during percutaneous infection (exsheathment), diverts the immune system to allow successful infection and reinfection in endemic areas. However, the physicochemical properties of the L3 larval cuticle and sheath, which are in direct contact with the skin and its immune defences, are unknown...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29199089/applying-asymptotic-methods-to-synthetic-biology-modelling-the-reaction-kinetics-of-the-mevalonate-pathway
#19
Mohit P Dalwadi, Marco Garavaglia, Joseph P Webb, John R King, Nigel P Minton
The mevalonate pathway is normally found in eukaryotes, and allows for the production of isoprenoids, a useful class of organic compounds. This pathway has been successfully introduced to Escherichia coli, enabling a biosynthetic production route for many isoprenoids. In this paper, we develop and solve a mathematical model for the concentration of metabolites in the mevalonate pathway over time, accounting for the loss of acetyl-CoA to other metabolic pathways. Additionally, we successfully test our theoretical predictions experimentally by introducing part of the pathway into Cupriavidus necator...
November 30, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29157661/analysis-of-codon-usage-pattern-of-mitochondrial-protein-coding-genes-in-different-hookworms
#20
Bornali Deb, Arif Uddin, Gulshana Akthar Mazumder, Supriyo Chakraborty
The phenomenon of unequal usage of synonymous codons encoding an amino acid in which some codons are more preferred to others is the codon usage bias (CUB) and it is species specific. Analysis of CUB helps in understanding evolution at molecular level and acquires significance in mRNA translation, design of transgenes and new gene discovery. In our current study, we analyzed synonymous codon usage pattern and the factors influencing it on mitochondrial protein coding genes of 6 different hookworms i.e. Ancylostoma ceylanicum, Ancylostoma duodenale, Necator americanus, Ancylostoma tubaeforme, Ancylostoma caninum and Uncinaria sanguinis as no work was reported yet...
November 17, 2017: Molecular and Biochemical Parasitology
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