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https://www.readbyqxmd.com/read/29678915/-ralstonia-eutropha-s-poly-3-hydroxybutyrate-phb-polymerase-phac1-and-phb-depolymerase-phaza1-are-phosphorylated-in-vivo
#1
Janina R Jüngert, Cameron Patterson, Dieter Jendrossek
In this study, we screened PHB synthase PhaC1 and PHB depolymerase PhaZa1 of Ralstonia eutropha for the presence of phosphorylated residues during the PHB accumulation and PHB degradation phase. Thr373 of PHB synthase PhaC1 was phosphorylated in the stationary growth phase but was not modified in the exponential and PHB accumulation phases. Ser35 of PHB depolymerase PhaZa1 was identified in phosphorylated form both in the exponential and in the stationary growth phase. Additional phosphosites were identified for both proteins in sample-dependent forms...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29670877/identification-of-inhibitors-in-lignocellulosic-slurries-and-determination-of-their-effect-on-hydrocarbon-producing-microorganisms
#2
Shihui Yang, Mary Ann Franden, Qing Yang, Yat-Chen Chou, Min Zhang, Philip T Pienkos
The aim of this work was to identify inhibitors in pretreated lignocellulosic slurries, evaluate high-throughput screening strategies, and investigate the impact of inhibitors on potential hydrocarbon-producing microorganisms. Compounds present in slurries that could inhibit microbial growth were identified through a detailed analysis of saccharified slurries by applying a combination of approaches of high-performance liquid chromatography, GC-MS, LC-DAD-MS, and ICP-MS. Several high-throughput assays were then evaluated to generate toxicity profiles...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29667925/massive-over-representation-of-solute-binding-proteins-sbps-from-the-tripartite-tricarboxylate-transporter-ttt-family-in-the-genome-of-the-%C3%AE-proteobacterium-rhodoplanes-sp-z2-yc6860
#3
Leonardo T Rosa, Vicki Springthorpe, Matheus E Bianconi, Gavin H Thomas, David J Kelly
Lineage-specific expansion (LSE) of protein families is a widespread phenomenon in many eukaryotic genomes, but is generally more limited in bacterial genomes. Here, we report the presence of 434 genes encoding solute-binding proteins (SBPs) from the tripartite tricarboxylate transporter (TTT) family, within the 8.2 Mb genome of the α-proteobacterium Rhodoplanes sp. Z2-YC6860, a gene family over-representation of unprecedented abundance in prokaryotes. Representing over 6 % of the total number of coding sequences, the SBP genes are distributed across the whole genome but are found rarely in low-GC islands, where the gene density for this family is much lower...
April 18, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29666725/elevated-serum-igg4-levels-in-a-young-patient-with-polyserositis-and-necator-americanus-infection
#4
Giuseppe D Sanna, Roberto Manetti, Valentina de Filippo, Sergio Babudieri
IgG4-related disease is a fibroinflammatory systemic condition characterized by tumefactive lesions, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 concentrations. It has been described in virtually every organ system. Autoimmunity and infectious agents are potential immunologic triggers in IgG4-related disease. Herein, we describe a peculiar case of effusive-constrictive pericarditis in an 18-year-old boy with polyserositis and concomitant Necator americanus infection...
2018: Case Reports in Immunology
https://www.readbyqxmd.com/read/29662713/are-the-skin-scar-characteristics-and-closure-of-the-parietal-peritoneum-associated-with-pelvic-adhesions
#5
Numan Çim, Erkan Elçi, Gülhan Güneş Elçi, Necat Almalı, Recep Yıldızhan
Objective: To assess whether the abdominal scar characteristics and closure of the peritoneum were associated with pelvic adhesions. Materials and Methods: Patients who had undergone cesarean section between December 2015 and February 2016 were assessed prospectively in terms of age, gravida, body mass index, number of living children, number of cesarean sections, time passed since the last cesarean section, closure status of the peritoneum in the last cesarean section, presence of other diseases, smoking status, location of incision in the abdomen (medial, pfannenstiel) scar dimensions (length, width), scar status with respect to skin (hypertrophic, flat, depressive), scar color [color change/no color change (hyperpigmented/hypopigmented)], adhesion of bowel-omentum-uterus, omentum-anterior abdominal wall, uterus-anterior abdominal wall, uterus-bladder, bladder-anterior abdominal wall, fixed uterus, and uterus-omentum-anterior abdominal wall in abdominal exploration...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29660658/nuclease-expression-in-efficient-polyhydroxyalkanoates-producing-bacteria-could-yield-cost-reduction-during-downstream-processing
#6
Jesús E Rodríguez Gamero, Lorenzo Favaro, Valentino Pizzocchero, Giovanna Lomolino, Marina Basaglia, Sergio Casella
Industrial manufacturing of polyhydroxyalkanoates (PHAs) requires purification of PHAs granules from high-cell-density cultures. Cells are broken by homogenization and PHAs granules are cleansed and treated to obtain PHAs latexes. However, cell lysis releases large amounts of DNA which results in an increasing viscosity of the medium, hampering the following downstream steps. Drop in viscosity is generally achieved by costly procedures such as heat treatment or the supplementation of hypochlorite and commercially available nucleases...
April 7, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29588070/parasite-allergens
#7
Luis Caraballo, Sandra Coronado
Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infections is intriguing that they are not usually associated with allergic symptoms, which probably (but not exclusively) depends on parasite-induced immunomodulation. However, allergic manifestations have been described during some helminth infections such as ascariasis, strongyloidiasis, anisakiasis and hydatidosis...
March 24, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29566094/a-novel-blood-feeding-detoxification-pathway-in-nippostrongylus-brasiliensis-l3-reveals-a-potential-checkpoint-for-arresting-hookworm-development
#8
Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam A T Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros
As part of on-going efforts to control hookworm infection, the "human hookworm vaccine initiative" has recognised blood feeding as a feasible therapeutic target for inducing immunity against hookworm infection. To this end, molecular approaches have been used to identify candidate targets, such as Necator americanus (Na) haemoglobinase aspartic protease-1 (APR-1), with immunogenicity profiled in canine and hamster models. We sought to accelerate the immune analysis of these identified therapeutic targets by developing an appropriate mouse model...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29563849/-ancylostoma-ceylanicum-novel-etiological-agent-for-traveler-s-diarrhea-report-of-four-japanese-patients-who-returned-from-southeast-asia-and-papua-new-guinea
#9
Masahide Yoshikawa, Yukiteru Ouji, Nobuyasu Hirai, Fukumi Nakamura-Uchiyama, Minoru Yamada, Naoki Arizono, Naoaki Akamatsu, Takaharu Yoh, Daisuke Kaya, Toshiya Nakatani, Eiryo Kikuchi, Yuichi Katanami, Kimitoshi Satoh, Ryosuke Maki, Yusuke Miyazato, Yuichiro Oba, Kei Kasahara, Keiichi Mikasa
Background: Countries in the Southeast Asia region have a high prevalence of soil-transmitted helminth, such as roundworm, whipworm, and hookworms [ Ancylostoma duodenale , Necator americanus , Ancylostoma ceylanicum ]. Recent molecular-based surveys have revealed that A . ceylanicum , a zoonotic hookworm, is likely the second most prevalent hookworm species infecting humans in that part of the world, while others have noted that this infection is an emerging public health risk not only for indigenous people but also for visitors from other countries...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29549002/development-of-a-plasmid-based-tunable-tolc-derived-expression-system-for-application-in-cupriavidus-necator-h16
#10
Elhussiny A Aboulnaga, Huibin Zou, Thorsten Selmer, Mo Xian
Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism...
March 13, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29536770/toxic-effect-of-acetamiprid-on-rana-ridibunda-sciatic-nerve-electrophysiological-and-histopathological-potential
#11
Yusuf Çamlıca, Salih Cüfer Bediz, Ülkü Çömelekoğlu, Şakir Necat Yilmaz
In this study, the effects of a neonicotinoid insecticide acetamiprid on the sciatic nerve of Rana ridibunda were investigated by using electrophysiological and histological methods. A total of 35 preparations of sciatic nerve isolated from 35 frogs (Nervus ischiadicus) were used in the experiments. Experiments were designed as four different dose groups (n = 8 per group). Acetamiprid solutions of 1 (group 1), 10 (group 2), 100 (group 3), and 1000 µM (group 4) were applied to the nerves in dose groups...
March 14, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29536712/-epidemic-status-of-human-key-parasitic-diseases-in-tongcheng-city-anhui-province
#12
Jiang Long-Zhi
OBJECTIVE: To understand the current status of key parasitic diseases in Tongcheng City, so as to provide an epidemiological reference for formulating the scientific planning for "13th Five-year" parasitic diseases prevention and control. METHODS: The villages of different levels in Tongcheng City were sampled to investigate the infection of parasitic diseases of residents aged three or more years. Soil-transmitted nemathelminth, intestinal protozoa and Enterobius vermicularis were investigated by the Kato-Katz technique (a fecal sample seized two), iodine smear method and cellophane tape method, respectively...
October 24, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29534987/transcriptomic-profiling-of-nematode-parasites-surviving-vaccine-exposure
#13
Guillaume Sallé, Roz Laing, James A Cotton, Kirsty Maitland, Axel Martinelli, Nancy Holroyd, Alan Tracey, Matthew Berriman, W David Smith, George F J Newlands, Eve Hanks, Eileen Devaney, Collette Britton
Some nematode species are economically important parasites of livestock, while others are important human pathogens causing some of the most important neglected tropical diseases. In both humans and animals, anthelmintic drug administration is the main control strategy, but the emergence of drug-resistant worms has stimulated the development of alternative control approaches. Among these, vaccination is considered to be a sustainable and cost effective strategy. Currently, Barbervax® for the ruminant strongylid Haemonchus contortus is the only registered subunit vaccine for a nematode parasite, although a vaccine for the human hookworm Necator americanus is undergoing clinical trials (HOOKVAC consortium)...
March 10, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29530348/synthesis-and-fungicidal-activity-of-novel-imidazole-based-ketene-dithioacetals
#14
Stephane Jeanmart, Julien Gagnepain, Pulakesh Maity, Clemens Lamberth, Fredrik Cederbaum, Ramya Rajan, Olivier Jacob, Mathias Blum, Stephane Bieri
Novel imidazole-based ketene dithioacetals show impressive in planta activity against the economically important plant pathogens Alternaria solani, Botryotinia fuckeliana, Erysiphe necator and Zymoseptoria tritici. Especially derivatives of the topical antifungal lanoconazole, which bear an alkynyloxy or a heteroaryl group in the para-position of the phenyl ring, exhibit excellent control of the mentioned phytopathogens. These compounds inhibit 14α -demethylase in the sterol biosynthesis pathway of the fungi...
March 9, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29505764/heligmosomoides-polygyrus-venom-allergen-like-protein-4-hpval-4-is-a-sterol-binding-protein
#15
Oluwatoyin A Asojo, Rabih Darwiche, Selam Gebremedhin, Geert Smant, Jose L Lozano-Torres, Claire Drurey, Jeroen Pollet, Rick M Maizels, Roger Schneiter, Ruud H P Wilbers
Heligmosomoides polygyrus bakeri is a model parasitic hookworm used to study animal and human helminth diseases. During infection, the parasite releases excretory/secretory (ES) products that modulate the immune system of the host. The most abundant protein family in ES products comprises the venom allergen-like proteins (VALs), which are members of the SCP/TAPS (Sperm-coating protein / Tpx / antigen 5 / pathogenesis related-1 / Sc7) superfamily. There are >30 secreted Heligmosomoides polygyrus VAL proteins (HpVALs) and these proteins are characterized by having either one or two 15 kDa CAP (cysteine-rich secretory protein (CRISP) / antigen 5 / pathogenesis related-1) domains...
March 2, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29490766/association-between-urticaria-and-nematode-infections
#16
Paola L Minciullo, Antonio Cascio, Sebastiano Gangemi
BACKGROUND: The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Moreover, urticaria may be detected in patients with parasitosis. Nematodes are a type of helminth that infect hundreds of millions of people throughout the world. OBJECTIVE: The aim of this work was to collect and review the published studies and cases of urticaria associated with nematode infections...
March 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29476619/sequential-processing-with-fermentative-caldicellulosiruptor-kronotskyensis-and-chemolithoautotrophic-cupriavidus-necator-for-converting-rice-straw-and-co-2-to-polyhydroxybutyrate
#17
Xiaowei Peng, Robert M Kelly, Yejun Han
Unpretreated rice straw was fermented by the extremely thermophilic bacterium Caldicellulosiruptor kronotskyensis, generating solubilized carbohydrates, organic acids, lignin-derived aromatics, H2 , and CO2 , which were subsequently used to produce polyhydroxybutyrate (PHB) by the chemolithoautotrophic bacterium Cupriavidus necator. The fermented liquid significantly enhanced the growth of C. necator, leading to a five-fold cell biomass yield, and a nine-fold PHB yield compared to what was obtained from conventional mineral media...
February 24, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29455681/human-dendritic-cell-sequestration-onto-the-necator-americanus-larval-sheath-during-ex-sheathing-a-possible-mechanism-for-immune-privilege
#18
A Hassan, D I Pritchard, A M Ghaemmaghami
Despite the profound health implications of Necator americanus infection in humans, many aspects of its interaction with the host immune system are poorly understood. Here we investigated the early events at the interface of N. americanus larvae (L3) and human dendritic cells (DCs). Our data show that co-culturing DCs and the larvae trigger ex-sheathing of hookworms rapidly where a majority of DCs are sequestered onto the larval sheath allowing the ex-sheathed larvae to migrate away unchallenged. Intriguingly, DCs show negligible interaction with the ex-sheathed larvae, alluding to differences between the surface chemistry of the larva and its sheath...
February 19, 2018: Parasitology
https://www.readbyqxmd.com/read/29440657/nippostrongylus-brasiliensis-infection-leads-to-impaired-reference-memory-and-myeloid-cell-interference
#19
T M Brombacher, K S De Gouveia, L Cruywagen, N Makena, F Booley, O Tamgue, F Brombacher
Hookworm infection is endemic in developing countries, leading to poor cognitive function-among other disruptions. In this study, the effects of Nippostrongylus brasiliensis infection (a murine model of Necator Americanus) on cognitive function were investigated. Though impaired cognition has been extensively reported, the exact domain of cognition affected is still unknown, hence requiring investigation. The objective of this study was to identify possible cognitive changes during Nippostrongylus brasiliensis infection in mice, using the Morris water maze...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29428963/efficacy-of-strain-elastography-in-diagnosis-and-staging-of-acute-appendicitis-in-pediatric-patients
#20
Harun Arslan, Zülküf Akdemir, Alpaslan Yavuz, Fahri Gökçal, Cemal Parlakgümüş, Necat İslamoglu, Hüseyin Akdeniz
BACKGROUND In the present study, the role and efficiency of strain elastography (SE) were evaluated in diagnosis and staging of acute appendicitis in pediatric patients. MATERIAL AND METHODS We enrolled 225 pediatric patients with suspected clinical and laboratory findings of acute appendicitis. Gray-scale sonographic findings were recorded and staging was made by the colorization method of SE imaging. Appendectomy was performed in all patients and the results of the surgical pathology were compared with the imaging findings...
February 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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