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JOURNAL ARTICLE
Stuart Campbell, Simon Smith, Josh Hanson
Existing recommended first-line antibiotic agents for MRSA pneumonia have several shortcomings. We reviewed 29 cases of community- and hospital-acquired MRSA pneumonia managed at our hospital. Lincosamide monotherapy was administered to 21/29 (72%) and was the predominant antibiotic regimen (> 50% course duration) in 19/29 (66%). Patients receiving lincosamide-predominant monotherapy were no more likely to die or require intensive care unit admission than patients receiving vancomycin-predominant monotherapy (5/19 (26%) versus 4/7 (57%), p = 0...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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JOURNAL ARTICLE
Xiao-Chen Wei, Ming-Feng Zhao, Xia Xiao
The objective of this study was to evaluate the efficacy of various dosing regimens of omadacycline against main drug-resistant pathogens in the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Monte Carlo simulations were conducted using pharmacokinetic parameters and pharmacodynamic data to calculate cumulative fractions of response (CFRs) in terms of drug area under the concentration curve/minimum inhibition concentration targets...
April 9, 2024: Journal of Chemotherapy
#3
JOURNAL ARTICLE
Hoang-Van Quang, Le-Thi Kim Nhung, Pham-Thi Thanh Thuy, Phan Chau Quyen, Le Bao Huy, Ho Si Dung
BACKGROUND: The rate of multi-drug antibiotic resistance in nosocomial bloodstream infections in elderly patients is increasing. This study examined the data for bloodstream infections to gain a better understanding of bacterial antibiotic resistance. METHODS: This was a retrospective study of 817 patients with the first positive blood culture between January 1, 2016 and December 31, 2019. RESULTS: Moyen's age was 77.4 ± 9.8 years, male (52...
2024: Materia Socio-medica
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JOURNAL ARTICLE
Kanao Kobayashi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Koichiro Wada, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Tohru Nakagawa, Tomoyuki Kaneko, Kazumasa Matsumoto, Tetsuya Fujimura, Jun Kamei, Kiyohito Ishikawa, Kiyohide Fujimoto, Yasushi Nakai, Katsumi Shigemura, Takuya Sadahira, Nobuyuki Hinata, Hiroyuki Kitano, Masuo Yamashita, Tomihiko Yasufuku, Hisao Komeda, Yoshiki Hiyama, Yoshito Takahashi, Sojun Kanamaru, Masaya Murakami, Soichi Arakawa, Daisuke Yamada, Koji Mita, Ryoichi Hamasuna, Kazushi Tanaka, Masanori Matsukawa, Eiichiro Takaoka, Masanobu Shigeta, Tadasu Takenaka, Masashi Nishino, Satoshi Ishitoya, Shohei Hayakawa, Kazuhiro Okumura, Masakatsu Ueda
INTRODUCTION: Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species. MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology...
April 6, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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JOURNAL ARTICLE
Michael McKelvey, Md Bashir Uddin, Sunil Palani, Shengjun Shao, Keer Sun
Immune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfection model resembles acute pneumonia patients undergoing appropriate antibiotic therapies...
April 4, 2024: American Journal of Respiratory Cell and Molecular Biology
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JOURNAL ARTICLE
Reza Gheitasi, Daniela Röll, Mario M Müller, Mohadeseh Naseri, Rainer König, Hortense Slevogt, Mathias W Pletz, Oliwia Makarewicz
Staphylococcus aureus is a highly successful pathogen infecting various body parts and forming biofilms on natural and artificial surfaces resulting in difficult-to-treat and chronic infections. We investigated the secreted cytokines and proteomes of isolated peripheral blood mononuclear cells (PBMCs) from healthy volunteers exposed to methicillin-resistant S. aureus (MRSA) biofilms or planktonic bacteria. Additionally, the cytokine profiles in sera from patients with community-acquired pneumonia (CAP) caused by S...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Sadaf Sajedi Moghaddam, Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi
BACKGROUND: Bloodstream infections (BSI) are the major cause of morbidity and mortality in children in developing countries. The purpose of the current study was to establish the antimicrobial susceptibility pattern of bacterial isolates from bloodstream infections at Children's Medical Center Hospital (CMC), Tehran, Iran. METHODS: We retrospectively recorded all positive blood cultures and antimicrobial susceptibility of all bloodstream isolates among children admitted to CMC, during 5 years...
April 3, 2024: BMC Infectious Diseases
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JOURNAL ARTICLE
Hila Ben-Amram, Maya Azrad, Jackie Cohen-Assodi, Adi Sharabi-Nov, Shimon Edelstein, Keren Agay-Shay, Avi Peretz
BACKGROUND: Hospital-acquired resistant infections (HARI) are infections, which develop 48 h or more after admission to a healthcare facility. HARI pose a considerably acute challenge, due to limited treatment options. These infections are associated bacterial biofilms, which act as a physical barrier to diverse external stresses, such as desiccation, antimicrobials and biocides. We assessed the influence of multiple factors on biofilm production by HARI -associated bacteria. METHODS: Bacteria were isolated from samples of patients with respiratory HARI who were hospitalized during 2020-2022 in north Israel...
April 2, 2024: Journal of Epidemiology and Global Health
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JOURNAL ARTICLE
Yang Yang, Zongze Yao, Jiazhen Zhang, Wei Shao, Bo Li, Huihui Wu, Wenjian Tang, Jing Zhang
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of staph infection that is difficult to treat because of resistance to some antibiotics. A recent study indicated that diarylurea ZJ-2 is a novel antibacterial agent against multi-drug resistant Enterococcus faecium . In this work, we refined the bactericidal mechanism of ZJ-2 as a peptidoglycan (PG) hydrolase by affecting AtlA-mediated PG homeostasis. METHODS: A wild-type strain (WT) and a mutant strain (Δ atlA ) were used to investigate the effects of ZJ-2 on the cell wall, PG, and autolysin regulatory system by antimicrobial susceptibility testing, hemolytic toxin assay, microanalysis, autolysis assay, qRT-PCR, ELISA and mouse model of pneumonia...
2024: Infection and Drug Resistance
#10
JOURNAL ARTICLE
Qianyu Bai, Yichi Zhang, Runqiu Cai, Haiyan Wu, Huiqun Fu, Xuemei Zhou, Jie Chai, Xuepeng Teng, Tianlong Liu
BACKGROUND: In the past decades, antimicrobial resistance (AMR) has been a major threat to global public health. Long-term, chronic otitis media is becoming more challenging to treat, thus the novel antibiotic alternative agents are much needed. METHODS: ZnO@TiO2 @AMP (ATZ NPs) were synthesized through a solvothermal method and subjected to comprehensive characterization. The in vitro and in vivo antibacterial effect and biocompatibility of ATZ NPs were evaluated...
2024: International Journal of Nanomedicine
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JOURNAL ARTICLE
Sanjith Saseedharan, Kapil Zirpe, Yatin Mehta, Dilip Dubey, Anand Sutar, Khokan Debnath, Sanket Newale
Background Antimicrobial resistance by bacteria poses a substantial threat to morbidity and mortality worldwide, and treatment of resistant infections is a challenge for the treating clinician. Levonadifloxacin is a novel broad-spectrum agent belonging to the benzoquinolizine subclass of quinolone, which can be used by both oral and intravenous administration for the treatment of infections caused by gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA). Patients and methods This prescription event monitoring study captured data from 1266 patients receiving levonadifloxacin (oral and/or IV) in a real-world setting to assess the safety and efficacy in the treatment of various bacterial infections...
February 2024: Curēus
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REVIEW
Xiaohua Qin, Li Ding, Min Hao, Pei Li, Fupin Hu, Minggui Wang
Antimicrobial resistance surveillance systems have been established in China. Two representative national surveillance networks are the China Antimicrobial Surveillance Network (CHINET) and China Antimicrobial Resistance Surveillance System (CARSS), both of which were established in 2005. For all clinical isolates collected in both of these surveillance networks, the ratio of Gram-negative bacilli to Gram-positive cocci was approximately 7:3 during the past 18 years. Generally, Gram-negative bacilli have a higher antimicrobial resistance profile in China...
April 2024: JAC-antimicrobial resistance
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JOURNAL ARTICLE
Marco Lopuzzo, Maria Teresa Montagna, Francesco Triggiano, Giuseppina Caggiano
INTRODUCTION: The correct method of surface disinfection in hospitals is an essential tool in the fight against the spread of healthcareassociated infections caused by multi-resistant microorganisms. Currently, there are many disinfectants on the market that can be used against different microorganisms. However, the effectiveness of different active molecules is controversial in the literature. STUDY DESIGN: The aim of this study was to evaluate the effectiveness of wipes based on hydrogen peroxide (1...
March 21, 2024: Annali di Igiene: Medicina Preventiva e di Comunità
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JOURNAL ARTICLE
Loïc Fonkoue, Elizabeth K Tissingh, Michelle Tognia Ngouateu, Kennedy Olivier Muluem, Olivier Ngongang, Pretty Mbouyap, Perrin Ngougni Pokem, Kuetche Fotsing, Jean Bahebeck, Martin McNally, Olivier Cornu
Fracture-related infection (FRI) is a common and devastating complication of orthopedic trauma in all settings. Data on the microbiological profile and susceptibility of FRI to antibiotics in low-income countries are scarce. Therefore, this study aimed to investigate the microbial patterns and antimicrobial susceptibility of FRI in a sub-Saharan African setting in order to provide guidance for the formulation of evidence-based empirical antimicrobial regimens. We conducted a retrospective analysis of patients treated for FRI with deep tissue sampling for microbiological culture from January 2016 to August 2023 in four tertiary-level hospitals in Yaoundé, Cameroon...
March 4, 2024: Antibiotics
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JOURNAL ARTICLE
Tatjana Mrvič, Sintija Stevanoska, Bojana Beović, Mateja Logar, Sergeja Gregorčič, Benica Žnidaršič, Katja Seme, Ivana Velimirović, Nataša Švent Kučina, Polona Maver Vodičar, Veronika Križan Hergouth, Sašo Džeroski, Mateja Pirs
The COVID-19 pandemic has strained healthcare systems globally. Shortages of hospital beds, reassignment of healthcare workers to COVID-19-dedicated wards, an increased workload, and evolving infection prevention and control measures have potentially contributed to the spread of multidrug-resistant bacteria (MDRB). To determine the impact of the COVID-19 pandemic at the University Medical Center Ljubljana, a tertiary teaching hospital, we analyzed the monthly incidence of select bacterial species per patient from 2018 to 2022...
February 23, 2024: Antibiotics
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JOURNAL ARTICLE
Ahmad M Eid, Hiba Natsheh, Linda Issa, Majdulin Zoabi, Monia Amer, Effat Mahamid, Ahmed Mousa
BACKGROUND: The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected to provide an important source for the natural products industry aiming to develop novel treatments for skin conditions. In this work, Capsicum annuum oleoresin nanoemulgel formulations have been prepared and investigated for their antibacterial and anticancer properties. METHODOLOGY: Several C...
2024: Current Pharmaceutical Design
#17
JOURNAL ARTICLE
Shaimaa Abdelaziz Abdelmoneim, Ramy Mohamed Ghazy, Eman Anwar Sultan, Mahmoud A Hassaan, Mohamed Anwar Mahgoub
Overuse of antibiotics during coronavirus disease 2019 (COVID-19) in an attempt to reduce COVID-19 mortality in the short term may have contributed to long-term mortality from antimicrobial resistance (AMR). The aim of this study was to evaluate the impact of the COVID-19 pandemic on AMR in Egypt and map the distribution of multidrug-resistant (MDR) and extensive drug-resistant (XDR) across Egypt. Through a multicenter cross-sectional study 2430 culture results were collected in 2019 and 2022 pre and post-COVID-19 pandemic in Egypt, including 400 Klebsiella pneumoniae, 760 Escherichia coli, 650 Acinetobacter baumannii, and 620 Methicillin-resistant staphylococcus aureus (MRSA) culture results...
March 26, 2024: Scientific Reports
#18
JOURNAL ARTICLE
E Mason, O Nsonwu, J Elmes, D Chudasama, C Pearson, L Hasan, R Hope, S M Gerver
A large increase in hospital-onset and intensive-care-unit-onset Staphylococcus aureus bacteraemia rates in English acute trusts was observed between 2020 and 2021, coinciding with reported increases in coronavirus disease (COVID-19) cases and associated hospitalizations. Many of these S. aureus bacteraemia cases were defined as co-/secondary infections to COVID-19. Over the same period, increases in the percentage of ventilator-associated pneumonia-related bacteraemia were also found. The COVID-19 pandemic appears to have contributed to the increase in hospital-onset S...
January 2024: Journal of Hospital Infection
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JOURNAL ARTICLE
Jiajia Liu, Shuai Zhao, Haiyang Yan, Suli Jin, Jingna Sun, Lidan Xing, Xiaoye Liu, Lisha Wang, Jing Chen
OBJECTIVE: Investigating the application effectiveness of using loop-mediated isothermal amplification (LAMP) on a microfluidic chip to detect the pathogens associated with ventilator-associated pneumonia (VAP). METHODS: Eighty samples of bronchoalveolar lavage fluid from patients with ventilator-associated pneumonia (VAP) were collected at The First Hospital of Hebei Medical University from July 2022 to July 2023. The bacterial culture technique and the LAMP method were used to detect the nucleic acid of the pathogens in the patient samples...
March 22, 2024: Alternative Therapies in Health and Medicine
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JOURNAL ARTICLE
Aneley Getahun Strobel, Prinika Prasad, Courtney R Lane, Ravi Naidu, Sanjeshni Autar, Tracey Young-Sharma, Matthew Richards, Ana Suka, Donna Cameron, Rodney James, Ravendra Prasad, Kirsty Buising, Benjamin P Howden, Vinita Prasad
BACKGROUND: There is a paucity of data on antimicrobial resistance in Fiji. The aim of this study was to determine the antimicrobial susceptibility profile of bacterial isolates from clinical samples at Colonial War Memorial Hospital in Fiji. METHODS: This retrospective study reviewed four-year of data from January 1, 2019, through December 31, 2022. Laboratory testing was carried out using locally approved protocols. Selective antimicrobial susceptibility testing was performed whereby only isolates resistant to first line antimicrobials were tested against second line antimicrobials...
April 2024: The Lancet Regional Health. Western Pacific
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