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https://www.readbyqxmd.com/read/29914961/activity-of-telavancin-against-s-aureus-isolated-from-cystic-fibrosis-patients-including-those-with-decreased-susceptibility-to-ceftaroline
#1
Melanie Roch, Maria Celeste Varela, Agustina Taglialegna, Warren E Rose, Adriana E Rosato
Methicillin-resistant Staphylococcus aureus (MRSA) acquisition in cystic fibrosis (CF) patients confers a worse clinical outcome with increased rate of declined lung function. Telavancin, an approved lipoglycopeptide used to treat infections due to S. aureus has a dual mode of action causing inhibition of the peptidoglycan synthesis and membrane depolarization. CF-associated MRSA infections remain an important problem with no foreseeable decline in prevalence rates. Although telavancin is currently in clinical use for complicated skin infections and hospital-acquired pneumonia, the activity against CF- associated S...
June 18, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29911455/delafloxacin-a-novel-fluoroquinolone-with-activity-against-methicillin-resistant-staphylococcus-aureus-mrsa-and-pseudomonas-aeruginosa
#2
Eric R Ocheretyaner, Tae Eun Park
The resistance to current antimicrobial agents, including fluoroquinolones, has continued to grow among various pathogens indicating a need for new antimicrobials to combat multi-drug resistant (MDR) organisms. In June 2017, delafloxacin received approval by the United States Food and Drug Administration for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) in adults caused by designated susceptible bacteria. Areas covered: This review describes the pharmacology, pharmacodynamics, pharmacokinetics, product information, efficacy, and safety of delafloxacin...
June 18, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29911241/green-synthesis-of-catalytic-gold-bismuth-oxyiodide-nanocomposites-with-oxygen-vacancies-for-treatment-of-bacterial-infections
#3
Chia-Lun Hsu, Yu-Jia Li, Hong-Jyuan Jian, Scott G Harroun, Shih-Chun Wei, Rini Ravindranath, Jui-Yang Lai, Chih-Ching Huang, Huan-Tsung Chang
We have developed a simple and green solution for the synthesis of catalytic gold-doped bismuth oxyiodide (Au/BiOI) nanocomposites at room temperature from an aqueous mixture of gold ions, bismuth ions, and iodide ions. Au nanoparticles (NPs) were formed in situ and doped into BiOI nanosheets. The oxygen vacancies generated in BiOI give rise to its oxidase-like activity, and Au doping facilitated the reaction leading to a 4-fold higher oxidase-like activity of the Au/BiOI nanocomposite. The Au/BiOI nanocomposites showed wide spectrum antimicrobial activity not only against non-multidrug-resistant E...
June 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29908309/anti-inflammatory-and-antibacterial-effects-of-thymus-sipyleus-boiss-subsp-sipyleus-boiss-var-sipyleus-l-essential-oil-against-rhinosinusitis-pathogens
#4
Fatih Demirci, Nursenem Karaca, Mehmet Tekin, Betül Demirci
Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. sipyleus L. of the Lamiaceae, locally known as thyme scented lemon, which is an endemic taxon collected from Sivas in Anatolia, was investigated in this study due to its folk medicine use against rhinosinusitis. The aromatic characteristics of the plant material gave the idea for the detailed evaluation of the volatiles and essential oil thereof. Consequently, the oil was obtained by Clevenger type hydrodistillation followed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography/mass spectrometry (GC/MS) analyses for phytochemical characterization...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29907877/electroporation-mediated-delivery-of-fer-gene-enhances-innate-immune-response-and-improves-survival-in-a-murine-model-of-pneumonia
#5
Vladislav Dolgachev, Sreehari Panicker, Sanjay Balijepalli, Lane Kelly McCandless, Yue Yin, Samantha Swamy, M V Suresh, Matthew J Delano, Mark R Hemmila, Krishnan Raghavendran, David Machado-Aranda
Previously, we reported that electroporation-mediated (EP) delivery of the FER gene improved survival in a combined trauma-pneumonia model. The mechanism of this protective effect is unknown. In this paper, we performed a pneumonia model in C57/BL6 mice with 500 CFU of Klebsiella pneumoniae. After inoculation, a plasmid encoding human FER was delivered by EP into the lung (PNA/pFER-EP). Survival of FER-treated vs. controls (PNA; PNA/EP-pcDNA) was recorded. In parallel cohorts, bronchial alveolar lavage (BAL) and lung were harvested at 24 and 72 h with markers of infection measured...
June 15, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29897466/increased-activity-of-linezolid-in-combination-with-rifampicin-in-a-murine-pneumonia-model-due-to-mrsa
#6
Yu-Feng Zhou, Yan Q Xiong, Meng-Ting Tao, Liang Li, Ming-Xiao Bu, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu
Objectives: The chloramphenicol/florfenicol resistance gene cfr, which mediates cross-resistance to linezolid and other classes of antimicrobial agents, represents a global therapeutic challenge due to its dissemination among MDR nosocomial pathogens, including MRSA. This study aimed to compare the efficacy of the linezolid/rifampicin combination in a murine pneumonia model caused by cfr-positive and cfr-negative clinical MRSA strains. Methods: Synergistic activity between linezolid and rifampicin was evaluated by chequerboard and time-kill assays...
April 20, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29897465/outcomes-associated-with-the-use-of-a-revised-risk-assessment-strategy-to-predict-antibiotic-resistance-in-community-onset-pneumonia-a-stewardship-perspective
#7
Andras Farkas, Joseph Sassine, Joseph P Mathew, Christine Stavropoulos, Ron Stern, George Mckinley
Objectives: There is growing evidence that patients with community-onset pneumonia and recent healthcare exposure are not at equally high risk of infection with MDR organisms. An individualized approach is necessary with regard to risk assessment and choice of antibiotics. Methods: We reviewed the records of 102 patients admitted for community-onset pneumonia, before and after the implementation of a revised risk assessment programme for MDR organisms using the drug resistance in pneumonia (DRIP) score...
June 11, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29893805/vancomycin-monotherapy-may-be-insufficient-to-treat-methicillin-resistant-staphylococcus-aureus-coinfection-in-children-with-influenza-related-critical-illness
#8
Adrienne G Randolph, Ruifei Xu, Tanya Novak, Margaret M Newhams, Juliane Bubeck Wardenburg, Scott L Weiss, Ronald C Sanders, Neal J Thomas, Mark W Hall, Keiko M Tarquinio, Natalie Cvijanovich, Rainer G Gedeit, Edward J Truemper, Barry Markovitz, Mary E Hartman, Kate G Ackerman, John S Giuliano, Steven L Shein, Kristin Moffitt
Background: Respiratory coinfection with influenza virus and methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening necrotizing pneumonia in children. Sporadic incidence precludes evaluation of antimicrobial efficacy. We assessed the clinical characteristics and outcomes of critically ill children with influenza-MRSA respiratory coinfection and evaluated antibiotic use. Methods: We prospectively enrolled children (<18 years) with influenza infection and acute respiratory failure across 34 pediatric intensive care units Nov 2008 to May 2016...
June 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29876099/the-tigecycline-evaluation-and-surveillance-trial-assessment-of-the-activity-of-tigecycline-and-other-selected-antibiotics-against-gram-positive-and-gram-negative-pathogens-from-france-collected-between-2004-and-2016
#9
Jean-Winoc Decousser, Paul-Louis Woerther, Claude-James Soussy, Marguerite Fines-Guyon, Michael J Dowzicky
Background: A high level of antibiotic consumption in France means antimicrobial resistance requires rigorous monitoring. The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) is a global surveillance study that monitors the in vitro activities of tigecycline and a panel of marketed antimicrobials against clinically important Gram-positive and Gram-negative isolates. Methods: Annually clinically relevant strains were prospectively included in the survey through a national network of hospital-based laboratories...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29868142/evolutionary-particularities-in-a-case-of-severe-pneumonia-in-children-case-report
#10
Marcela Daniela Ionescu, Nicoleta Aurelia Popescu, Georgiana Balan, Veronica Marcu, Augustina Enculescu, Lorena Vatra, Marcel Oancea, Mihaela Balgradean
Necrotizing pneumonia remains an uncommon complication of pneumonia in children, but its incidence is increasing. Pneumococcal infection is the predominant cause of severe necrotizing pneumonia in children, but methicillin resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin (PVL) staphylococcal infections are also important. We present the case of a four-year-old girl,with an unremarkable medical history, who was admitted in our hospital with a history of high fever, productive cough and tachypnea lasting for 10 days, progressive worsening despite empirical oral antibiotic...
March 2018: Mædica
https://www.readbyqxmd.com/read/29845929/process-and-outcome-indicators-for-infection-control-and-prevention-in-european-acute-care-hospitals-in-2011-to-2012-results-of-the-prohibit-study
#11
Sonja Hansen, Frank Schwab, Walter Zingg, Petra Gastmeier, The Prohibit Study Group
IntroductionHospitals from 24 European countries were asked for information on infection prevention and control (IPC) indicators as part of the Prevention of Hospital Infections by Intervention and Training (PROHIBIT) survey. Methods: Leading IPC personnel of 297 hospitals with established healthcare-associated infection (HCAI) surveillance provided information on local surveillance and feedback by using a questionnaire. Results: Most hospitals focused on bloodstream infection (BSI) (n = 251) and surgical site infection (SSI) (n = 254), with a SSI post-discharge surveillance in 148 hospitals...
May 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29845863/drug-resistant-staphylococcus-aureus-strains-reveal-distinct-biochemical-features-with-raman-microspectroscopy
#12
Oscar Daniel Ayala, Catherine Wakeman, Isaac J Pence, Eric P Skaar, Anita Mahadevan-Jansen
Staphylococcus aureus is a leading cause of hospital-acquired infections, such as bacteremia, pneumonia, and endocarditis. Treatment of these infections can be challenging since strains of S. aureus, such as methicillin-resistant S. aureus (MRSA), have evolved resistance to antimicrobials. Current methods to identify infectious agents in hospital environments often rely on time-consuming, multi-step culturing techniques to distinguish problematic strains (i.e. antimicrobial resistant variants) of a particular bacterial species...
May 30, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29804135/decontaminating-surfaces-with-atomized-disinfectants-generated-by-a-novel-thickness-mode-lithium-niobate-device
#13
Monika Kumaraswamy, Sean Collignon, Carter Do, Janie Kim, Victor Nizet, James Friend
We evaluated the ability of a novel lithium niobate (LN) thickness-mode device to atomize disinfectants and reduce microbial burden on model surface materials. A small-scale plastic model housed the LN thickness-mode device and circular coupon surface materials including polycarbonate, polyethylene terephthalate, stainless steel, borosilicate glass, and natural rubber. Coupon surfaces were coated with methicillin-resistant Staphylococcus aureus (MRSA) or multidrug-resistant (MDR) strains of Gram-negative bacterial pathogens (Klebsiella pneumoniae, Escherichia coli, and Acinetobacter baumannii), atomized with disinfectant solutions of varying viscosity (including 10% bleach, 70% ethanol (EtOH), or 25% triethylene glycol (TEG)) using the LN thickness-mode device, and assessed for surviving bacteria...
May 26, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29791769/bioprospecting-from-marine-coastal-sediments-of-colombian-caribbean-screening-and-study-of-antimicrobial-activity
#14
M Quintero, A Velásquez, L M Jutinico, E Jiménez-Vergara, L M Blandón, K Martinez, H S Lee, J Gómez-León
AIMS: To isolate microorganisms associated to marine - coastal sediments of colombian Caribbean and for evaluating its antimicrobial activity in order to identify the most active strains. METHODS AND RESULTS: 104 strains were isolated from sediment samples of the colombian Caribbean. First at all, an antimicrobial activity screening was made using agar well diffusion method against the pathogens: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, Candida tropicalis and Pseudomonas aeruginosa...
May 23, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29784578/quantitative-study-about-the-role-of-environmental-conditions-in-the-survival-capability-of-multidrug-resistant-bacteria
#15
Adrienn Hanczvikkel, Ákos Tóth
BACKGROUND: Healthcare-associated infections (HAIs) caused by multidrug-resistant bacteria (MDRB) are of global concern and hospital textiles can contribute to their transmission. MDRB are able to survive on textiles for more than enough time to spread in the environment. Some studies summarized the effect of environmental factors on the duration of bacterial survival, but it remained an open question how these factors influence the quantity of surviving bacteria in a period of a few days, which is relevant from the perspective of HAIs...
May 18, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29771255/return-of-the-tetracyclines-omadacycline-a-novel-aminomethylcycline-antimicrobial
#16
J C Cho, L M Childs-Kean, M T Zmarlicka, M P Crotty
Omadacycline is a novel aminomethylcycline antimicrobial agent that is available in both oral and intravenous formulations. The distinguishing structural characteristics of omadacycline from other tetracyclines allow for its continued antimicrobial activity in the presence of traditional tetracycline resistance mechanisms (efflux pumps and ribosomal protection proteins). Omadacycline has been found to have potent activity against antibiotic-resistant pathogens including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, extended spectrum beta-lactamase-producing Escherichia coli and multidrug-resistant Streptococcus pneumoniae...
March 2018: Drugs of Today
https://www.readbyqxmd.com/read/29765236/methicillin-resistant-staphylococcus-aureus-bacteremia-among-liver-transplant-recipients-epidemiology-and-associated-risk-factors-for-morbidity-and-mortality
#17
REVIEW
Taohua Liu, Yuezhong Zhang, Qiquan Wan
Bacteremia due to Staphylococcus aureus , especially methicillin-resistant S. aureus (MRSA), complicates the clinical course of liver transplantation and is associated with high morbidity and mortality. Intravascular catheters had been reported to be the most frequent source of MRSA bacteremia. Among bacteremic liver recipients, 26.3%-100% of S. aureus were MRSA. Previous studies identified pre-transplant and post-transplant acquired S. aureus carriage, greater severity of liver disease, hepatocellular carcinoma and infection with immuno-modulatory viruses as predictors of S...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29762662/national-costs-associated-with-methicillin-susceptible-and-methicillin-resistant-s-aureus-hospitalizations-in-the-united-states-2010-2014
#18
Eili Y Klein, Wendi Jiang, Nestor Mojica, Katie K Tseng, Ryan McNeill, Sara E Cosgrove, Trish M Perl
Background: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have been associated with worse patient outcomes and higher costs of care than susceptible (MSSA) infections. However, the healthcare landscape has changed since prior studies found these differences, including widespread dissemination of community-associated strains of MRSA. Our objective was to provide updated estimates of the excess costs of resistant S. aureus infections. Methods: We conducted a retrospective analysis using data from the National Inpatient Sample from the Agency for Healthcare Research and Quality for the years 2010 to 2014...
May 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29746358/delayed-cerebral-injury-in-adults-with-bacterial-meningitis-a-novel-complication-of-adjunctive-steroids
#19
Cinthia Gallegos, Farrell Tobowlosky, Masayuki Nigo, Rodrigo Hasbun
OBJECTIVES: To report the prevalence of delayed cerebral injury in adults with bacterial meningitis and explore its association with adjunctive steroids. DESIGN: Retrospective analysis of adults with bacterial meningitis between 2005 and 2016. SETTING: Ten hospitals in the Greater Houston area. PATIENTS: Consecutive subjects with culture proven community-acquired bacterial meningitis. INTERVENTION: Subjects were categorized as receiving or not adjunctive steroids within 4 hours...
May 9, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29740989/activity-of-fosfomycin-against-nosocomial-multiresistant-bacterial-pathogens-from-croatia-a-multicentric-study
#20
Luka Bielen, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić-Medić, Ana Godan, Ivan Tomić, Blaženka Hunjak, Alemka Markotić, Danijela Bejuk, Vladimira Tičić, Silvana Balzar, Branka Bedenić
AIM: To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. METHODS: In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics...
April 30, 2018: Croatian Medical Journal
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