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https://www.readbyqxmd.com/read/29166563/mechanochemical-synthesis-of-pharmaceutical-cocrystal-suspensions-via-hot-melt-extrusion-enhancing-cocrystal-yield
#1
Shu Li, Tao Yu, Yiwei Tian, Colette Lagan, David S Jones, Gavin P Andrews
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability. Our previous work has demonstrated the viability of in-situ formation of ibuprofen/isonicotinamide cocrystal suspensions within a matrix carrier via a single-step hot-melt extrusion (HME) process. The key aim of the current work is to establish optimised processing conditions to improve cocrystal yield within extruded matrices...
November 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29166286/a-trial-of-doramectin-injection-and-ivermectin-spot-on-for-treatment-of-rabbits-artificially-infested-with-the-ear-mite-psoroptes-cuniculi
#2
N M Elhawary, Sh S G H Sorour, M A El-Abasy, E K Bazh, K Sultan
The ear mite "Psoroptes cuniculi" is the main cause of ear mange, a highly contagious parasitic skin disease in rabbits all over the world. In the current work, a preliminary therapeutic trial to study the effect of the broad use acaricides doramectin and ivermectin on P. cuniculi was performed on artificially infested rabbits. Twenty five adult New Zealand white rabbits were used in this study. The rabbits were assigned randomly into five groups/ 5 rabbits in each group. Each rabbit was experimentally infested with 100 mites/ ear...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29166109/temperature-and-chain-length-dependence-of-ultrafast-vibrational-dynamics-of-thiocyanate-in-alkylimidazolium-ionic-liquids-a-random-walk-on-a-rugged-energy-landscape
#3
Thomas Brinzer, Sean Garrett-Roe
Ultrafast two-dimensional infrared spectroscopy of a thiocyanate vibrational probe (SCN(-)) was used to investigate local dynamics in alkylimidazolium bis-[trifluoromethylsulfonyl]imide ionic liquids ([Imn,1][Tf2N], n = 2, 4, 6) at temperatures from 5 to 80 °C. The rate of frequency fluctuations reported by SCN(-) increases with increasing temperature and decreasing alkyl chain length. Temperature-dependent correlation times scale proportionally to temperature-dependent bulk viscosities of each ionic liquid studied...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166084/on-the-electron-density-localization-in-elemental-cubic-ceramic-and-fcc-transition-metals-by-means-of-a-localized-electrons-detector
#4
Yosslen Aray, Ricardo Paredes, Luis Javier Álvarez, Alejandro Martiz
The electron density localization in insulator and semiconductor elemental cubic materials with diamond structure, carbon, silicon, germanium, and tin, and good metallic conductors with face centered cubic structure such as α-Co, Ni, Cu, Rh, Pd, Ag, Ir, Pt, and Au, was studied using a localized electrons detector defined in the local moment representation. Our results clearly show an opposite pattern of the electron density localization for the cubic ceramic and transition metal materials. It was found that, for the elemental ceramic materials, the zone of low electron localization is very small and is mainly localized on the atomic basin edges...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165784/interventions-for-managing-skeletal-muscle-spasticity-following-traumatic-brain-injury
#5
REVIEW
Anneliese Synnot, Marisa Chau, Veronica Pitt, Denise O'Connor, Russell L Gruen, Jason Wasiak, Ornella Clavisi, Loyal Pattuwage, Kate Phillips
BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29165323/negative-differential-mobility-and-trapping-in-active-matter-systems
#6
Charles Reichhardt, Cynthia J Olson Reichhardt
Using simulations, we examine the average velocity as a function of applied drift force for active matter particles moving through a random obstacle array. We find that for low drift force, there is an initial flow regime where the mobility increases linearly with drive, while for higher drift forces a regime of negative differential mobility appears in which the velocity decreases with increasing drive due to the trapping of active particles behind obstacles. A fully clogged regime exists at very high drift forces when all the particles are permanently trapped behind obstacles...
November 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29165232/functional-analysis-of-the-esab-component-of-the-staphylococcus-aureus-type-vii-secretion-system
#7
M Guillermina Casabona, Grant Buchanan, Martin Zoltner, Catriona P Harkins, Matthew T G Holden, Tracy Palmer
Type VII secretion systems (T7SS) are found in many bacteria and secrete proteins involved in virulence and bacterial competition. In Staphylococcus aureus the small ubiquitin-like EsaB protein has been previously implicated as having a regulatory role in the production of the EsxC substrate. Here we show that in the S. aureus RN6390 strain, EsaB does not genetically regulate production of any T7 substrates or components, but is indispensable for secretion activity. Consistent with EsaB being an essential component of the T7SS, loss of either EsaB or EssC are associated with upregulation of a common set of iron acquisition genes...
November 22, 2017: Microbiology
https://www.readbyqxmd.com/read/29165123/prevalence-and-risk-factors-associated-with-hypertension-and-prehypertension-in-a-working-population-at-high-altitude-in-china-a-cross-sectional-study
#8
Yang Shen, Chun Chang, Jingru Zhang, Ying Jiang, Bingying Ni, Yanling Wang
BACKGROUND: Little information is available on the epidemiology of hypertension and prehypertension at high altitude in China, the aim of this study was to determine the prevalence of hypertension, prehypertension and their risk factors among Chinese working population at high altitude regions. METHODS: A cross-sectional survey was performed in an occupational sample of 4198 employees aged 20-59 years on Qinghai-Tibet Plateau between May to July 2013. Information from a self-administered questionnaire, physical examinations and laboratory measurements were obtained from each participant...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165111/population-profile-and-residential-environment-of-an-urban-poor-community-in-dhaka-bangladesh
#9
Md Khalequzzaman, Chifa Chiang, Bilqis Amin Hoque, Sohel Reza Choudhury, Saika Nizam, Hiroshi Yatsuya, Akiko Matsuyama, Yoshihisa Hirakawa, Syed Shariful Islam, Hiroyasu Iso, Atsuko Aoyama
OBJECTIVES: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor. METHODS: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member...
March 14, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165065/electrochemical-nucleic-acid-based-biosensing-of-drugs-of-abuse-and-pharmaceuticals
#10
Susana Campuzano, Maia Pedrero, Jose M Pingarron
Nowadays, studies of the interactions of DNA with small molecular drugs, especially anti-tumor agents, antibiotics and drugs of abuse are currently performed to explore their mechanism of action and develop new drugs with lower side effects and high curative properties. Currently, electrochemical biosensors are considered a very promising alternative analytical tool to conventional more complex techniques for drug determination due to rapidness, low cost, high sensitivity, compatibility with microfabrication technology, intuitively understandable design and simple operation mode...
November 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29164599/neurocognition-and-subjective-experience-following-acute-doses-of-the-synthetic-cannabinoid-jwh-018-a-phase-1-placebo-controlled-pilot-study
#11
Eef L Theunissen, Nadia R P W Hutten, Natasha L Mason, Stefan W Toennes, Kim P C Kuypers, Eliza B de Sousa Fernandes Perna, Johannes G Ramaekers
BACKGROUND AND PURPOSE: Synthetic cannabinoids (often sold as Spice or K2) have become a very popular alternative to cannabis due to the easy access and portrayed safety. Controlled studies on the behavioral effects of synthetic cannabinoids are currently lacking, which hampers risk assessments of these compounds. EXPERIMENTAL APPROACH: This is a first attempt to assess the influence of a synthetic cannabinoid, JWH-018, on neurocognition and subjective experience in humans after controlled administration...
November 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29164376/evaluation-of-quality-of-life-in-caregivers-who-are-providing-home-care-to-cancer-patients
#12
Mahcube Cubukcu
PURPOSE: The author aimed to evaluate the quality of life and the factors affecting the caregivers of cancer patients receiving home care. METHODS: This cross-sectional descriptive study was performed in 48 cancer patients who were served from home care unit and 48 caregivers between 01 and 28 February 2014. Patients' functional status was evaluated with Katz Index for Activities of Daily Living and the Lawton Scale for Instrumental Activities of Daily Living. The levels of quality of life of caregivers of patients with cancer were determined with Caregiver Quality of Life Index-Cancer (CQOLC)...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29164356/investigating-the-impacts-of-treated-effluent-discharge-on-coastal-water-health-visakhapatnam-sw-coast-of-bay-of-bengal-india
#13
Aziz Ur Rahman Shaik, Haimanti Biswas, N Surendra Babu, N P C Reddy, Z A Ansari
The present study investigated the impacts of treated effluent discharge on physicochemical and biological properties of coastal waters from three pharmaceuticals situated along the coast of Visakhapatnam (SW Bay of Bengal). Seawater samples were collected (during the months of December 2013, March 2014 and April 2014) from different sampling locations (Chippada (CHP), Tikkavanipalem (TKP) and Nakkapalli (NKP)) at 0- and 30-m depths within 2-km radius (0.5 km = inner, 1 km = middle and 2 km = outer sampling circles) from the marine outfall points...
November 21, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29164092/the-nuisance-mosquito-anopheles-plumbeus-stephens-1828-in-germany-a-questionnaire-survey-may-help-support-surveillance-and-control
#14
Eva C Heym, Jette Schröder, Helge Kampen, Doreen Walther
The mosquito species Anopheles plumbeus is an aggressive biter and a potential vector of malaria parasites and West Nile virus. It occurs naturally at low population densities, as its larval development is adapted to the specific water qualities found in tree holes. However, probably owing to environmental changes, it has recently been observed in several European countries to use increasingly often artificial breeding habitats that may lead to mass development and severe annoyance to humans living close by...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29164058/delineation-of-the-hpv11e6-and-hpv18e6-pathways-in-initiating-cellular-transformation
#15
Lamech M Mwapagha, Nicki Tiffin, M Iqbal Parker
Although high-risk human papillomaviruses (HPVs) are the major risk factors for cervical cancer they have been associated with several other cancers, such as head and neck and oral cancers. Since integration of low-risk HPV11 DNA has been demonstrated in esophageal tumor genomes, this study compared the effects of low-risk HPV11E6 and high-risk HPV18E6 on cellular gene expression. The HPV11E6 and HPV18E6 genes were cloned into an adenoviral vector and expressed in human keratinocytes (HaCaT) in order to investigate early events and to eliminate possible artifacts introduced by selective survival of fast growing cells in stable transfection experiments...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29164038/timing-of-decompression-in-patients-with-acute-spinal-cord-injury-a-systematic-review
#16
REVIEW
Jefferson R Wilson, Lindsay A Tetreault, Brian K Kwon, Paul M Arnold, Thomas E Mroz, Christopher Shaffrey, James S Harrop, Jens R Chapman, Steve Casha, Andrea C Skelly, Haley K Holmer, Erika D Brodt, Michael G Fehlings
Study Design: Systematic review. Objective: To conduct a systematic review and synthesis of the literature to assess the comparative effectiveness, safety, and cost-effectiveness of early (≤24 hours) versus late decompression (>24 hours) in adults with acute spinal cord injury (SCI). Methods: A systematic search was conducted of Medline, EMBASE, the Cochrane Collaboration Library, and Google Scholar to identify studies published through November 6, 2014...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164033/change-in-functional-impairment-disability-and-quality-of-life-following-operative-treatment-for-degenerative-cervical-myelopathy-a-systematic-review-and-meta-analysis
#17
REVIEW
Michael G Fehlings, Lindsay A Tetreault, Shekar Kurpad, Darrel S Brodke, Jefferson R Wilson, Justin S Smith, Paul M Arnold, Erika D Brodt, Joseph R Dettori
Study Design: Systematic review. Objectives: The primary objective of this systematic review was to define the change in impairment, disability, and pain following surgical intervention in patients with degenerative cervical myelopathy (DCM). Secondary objectives included to assess the impact of preoperative disease severity and duration of symptoms on outcomes and to summarize complications associated with surgery. Methods: A systematic literature search was conducted to identify prospective studies evaluating the effectiveness and safety of operative treatment in patients with DCM...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164032/change-in-function-pain-and-quality-of-life-following-structured-nonoperative-treatment-in-patients-with-degenerative-cervical-myelopathy-a-systematic-review
#18
REVIEW
Lindsay A Tetreault, John Rhee, Heidi Prather, Brian K Kwon, Jefferson R Wilson, Allan R Martin, Ian B Andersson, Anna H Dembek, Krystle T Pagarigan, Joseph R Dettori, Michael G Fehlings
Study Design: Systematic review. Objectives: The objective of this study was to conduct a systematic review to determine (1) change in function, pain, and quality of life following structured nonoperative treatment for degenerative cervical myelopathy (DCM); (2) variability of change in function, pain, and quality of life following different types of structured nonoperative treatment; (3) differences in outcomes observed between certain subgroups (eg, baseline severity score, duration of symptoms); and (4) negative outcomes and harms resulting from structured nonoperative treatment...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164028/a-clinical-practice-guideline-for-the-management-of-patients-with-acute-spinal-cord-injury-recommendations-on-the-role-of-baseline-magnetic-resonance-imaging-in-clinical-decision-making-and-outcome-prediction
#19
Michael G Fehlings, Allan R Martin, Lindsay A Tetreault, Bizhan Aarabi, Paul Anderson, Paul M Arnold, Darrel Brodke, Anthony S Burns, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, Gregory Hawryluk, Langston T Holly, Susan Howley, Tara Jeji, Sukhvinder Kalsi-Ryan, Mark Kotter, Shekar Kurpad, Brian K Kwon, Ralph J Marino, Eric Massicotte, Geno Merli, James W Middleton, Hiroaki Nakashima, Narihito Nagoshi, Katherine Palmieri, Anoushka Singh, Andrea C Skelly, Eve C Tsai, Alexander Vaccaro, Jefferson R Wilson, Albert Yee, James S Harrop
Introduction: The objective of this guideline is to outline the role of magnetic resonance imaging (MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury (SCI). Methods: A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI. This review focused on longitudinal studies that controlled for baseline neurologic status. A multidisciplinary Guideline Development Group (GDG) used this information, their clinical expertise, and patient input to develop recommendations on the use of MRI for SCI patients...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164022/impact-of-baseline-magnetic-resonance-imaging-on-neurologic-functional-and-safety-outcomes-in-patients-with-acute-traumatic-spinal-cord-injury
#20
REVIEW
Shekar Kurpad, Allan R Martin, Lindsay A Tetreault, Dena J Fischer, Andrea C Skelly, David Mikulis, Adam Flanders, Bizhan Aarabi, Thomas E Mroz, Eve C Tsai, Michael G Fehlings
Study Design: Systematic review. Objective: To perform a systematic review to evaluate the utility of magnetic resonance imaging (MRI) in patients with acute spinal cord injury (SCI). Methods: An electronic search of Medline, EMBASE, the Cochrane Collaboration Library, and Google Scholar was conducted for literature published through May 12, 2015, to answer key questions associated with the use of MRI in patients with acute SCI. Results: The literature search yielded 796 potentially relevant citations, 8 of which were included in this review...
September 2017: Global Spine Journal
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