Gourav Singh, Gauri Shankar, Samir Ranjan Panda, Sunil Kumar, Sanskriti Rai, Himanshu Verma, Prabhat Kumar, Prasanta Kumar Nayak, V G M Naidu, Saripella Srikrishna, Saroj Kumar, Gyan Modi
Alzheimer's disease (AD) is the most common cause of dementia, which arises due to low levels of acetyl and butyrylcholines, an increase in oxidative stress, inflammation, metal dyshomeostasis, Aβ and tau aggregations. The currently available drugs for AD treatment can provide only symptomatic relief without interfering with pathological hallmarks of the disease. In our ongoing efforts to develop naturally inspired novel multifunctional molecules for AD, systematic SAR studies on EJMC-4e were caried out to improve its multifunctional properties...
March 25, 2024: ACS Chemical Neuroscience