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https://www.readbyqxmd.com/read/27890733/differences-in-the-onset-mode-of-ventricular-tachyarrhythmia-between-patients-with-j-wave-in-anterior-leads-versus-inferolateral-leads
#1
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
BACKGROUND: The pathophysiological mechanism of J wave in anterior leads (A-leads) and inferolateral leads (L-leads) remains unclear. OBJECTIVE: We investigated the onset mode and circadian distribution of ventricular tachyarrhythmia (VTA) episodes in patients with early repolarization syndrome (ERS) and Brugada syndrome (BrS). METHODS: The study enrolled 35 ERS patients and 52 type 1 BrS patients with spontaneous ventricular fibrillation who were divided into four groups: ERS(A+L) (n=15), ERS patients who had non-type 1 Brugada-pattern electrocardiogram (ECG) in any A-leads (2(nd) to 4(th) intercostal spaces) in control and/or after drug provocation tests; ERS(L) (n=20), ERS with J wave only in L-leads; BrS(A) (n=24), BrS without J wave in L-leads; and, BrS(A+L) (n=28), BrS with J wave in L-leads...
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27885745/exaggerated-reactivity-of-parasympathetic-nerves-is-involved-in-ventricular-fibrillation-in-j-wave-syndrome
#2
Tetsuji Shinohara, Hidekazu Kondo, Toyokazu Otsubo, Akira Fukui, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
INTRODUCTION: Brugada syndrome (BrS) and early repolarization syndrome (ERS) are termed the J-wave syndrome. In most cases of J-wave syndrome, ventricular fibrillation (VF) often occurs around midnight or in the early morning when parasympathetic tone is augmented. OBJECTIVE: The purpose of this study was to clarify the relationship between VF and autonomic nervous activity in patients with J-wave syndrome. METHODS AND RESULTS: We enrolled 28 consecutive patients with J-wave syndrome (20 BrS and 8 ERS) in whom implantable cardioverter-defibrillators (ICDs) were implanted between January 2002 and December 2014...
November 25, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27830074/sodium-channel-blockade-unmasked-brugada-electrocardiographic-pattern-in-a-patient-with-complete-right-bundle-branch-block-and-early-repolarization-in-the-lateral-leads
#3
Shozo Konishi, Hitoshi Minamiguchi, Yuji Okuyama, Yasushi Sakata
Early repolarization syndrome (ERS) and Brugada syndrome (BrS) share many electrocardiographic and clinical features, and recently have been collectively grouped as J wave syndrome. However, the effects of sodium channel blockers on the J waves differ greatly between ERS and BrS.
November 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27761155/j-wave-syndromes-expert-consensus-conference-report-emerging-concepts-and-gaps-in-knowledge
#4
Charles Antzelevitch, Gan-Xin Yan, Michael J Ackerman, Martin Borggrefe, Domenico Corrado, Jihong Guo, Ihor Gussak, Can Hasdemir, Minoru Horie, Heikki Huikuri, Changsheng Ma, Hiroshi Morita, Gi-Byoung Nam, Frederic Sacher, Wataru Shimizu, Sami Viskin, Arthur A M Wilde
No abstract text is available yet for this article.
October 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27759343/early-repolarisation-changes-in-ecg-are-they-benign-or-malignant
#5
Oruganti Sai Satish, K Sashikanth Srivastav
Till recently, ST segment elevation in the absence of conduction abnormalities or chest pain occurring particularly in young bradycardia individuals has been considered a normal variant called early repolarisation (ER). However, recent studies suggest a more worrisome picture as patients with history of idiopathic ventricular fibrillation showed increased prevalence of ER in ECG. ER is an ECG pattern characterised by elevation of the QRS-ST junction (J point) ≥ 2 mv from baseline in the inferior (II, III, aVF) or lateral (I, aVL, V4-V6) leads manifested as QRS slurring or notching...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27733953/predictors-of-calf-arterial-compliance-in-male-veterans-with-psychiatric-diagnoses
#6
Maju Mathew Koola, John D Sorkin, Molly Fargotstein, W Virgil Brown, Bruce Cuthbert, Jeffrey Hollis, Jeffrey K Raines, Erica J Duncan
BACKGROUND: Peripheral arterial compliance (PAC) is a measure of the ability of the vascular tree to dilate in response to a pressure wave. Reduced PAC is seen in patients with psychiatric diagnoses and has been associated with increased risk for stroke, myocardial infarction, and mortality. The objective of this pilot study was to identify predictors of reduced PAC in subjects with psychiatric diagnoses. METHODS: Male psychiatric subjects (N = 77) were studied in a cross-sectional study of medication effects on PAC conducted from August 2005 to February 2010...
2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27721848/j-wave-syndromes-history-and-current-controversies
#7
Tong Liu, Jifeng Zheng, Gan-Xin Yan
The concept of J wave syndromes was first proposed in 2004 by Yan et al for a spectrum of electrocardiographic (ECG) manifestations of prominent J waves that are associated with a potential to predispose affected individuals to ventricular fibrillation (VF). Although the concept of J wave syndromes is widely used and accepted, there has been tremendous debate over the definition of J wave, its ionic and cellular basis and arrhythmogenic mechanism. In this review article, we attempted to discuss the history from which the concept of J wave syndromes (JWS) is evolved and current controversies in JWS...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27680806/e5-lung-ultrasound-and-echocardiography-for-peripartum-haemodynamic-monitoring-of-patients-with-severe-preeclampsia
#8
J Ambrozic, K Prokselj, M Lucovnik
INTRODUCTION: The ability to judge intravascular volume is fundamental in the management of patients with severe preeclampsia. Insufficient intravascular volume can result in decreased oxygen delivery to tissues and exacerbates organ dysfunction. On the other hand, fluid excesses can lead to fluid extravasation and pulmonary edema. Outside of pregnancy, transthoracic echocardiography and lung ultrasonography have become important diagnostic and monitoring tools in critically ill patients...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27641950/identification-of-a-novel-mutation-in-hps6-in-a-patient-with-hemophilia-b-and-oculocutaneous-albinism
#9
Kevin J O'Brien, Jay Lozier, Andrew R Cullinane, Brigitte Osorio, Khanh Nghiem, Vladislav Speransky, Wadih M Zein, James C Mullikin, Anne T Neff, Karen L Simon, May Christine V Malicdan, William A Gahl, Lisa R Young, Bernadette R Gochuico
PURPOSE: Hemophilia B, an X-linked disease, manifests with recurrent soft tissue bleeding episodes. Hermansky-Pudlak syndrome, a rare autosomal recessive disorder, is characterized by oculocutaneous albinism and an increased tendency to bleed due to a platelet storage pool defect. We report a novel mutation in HPS6 in a Caucasian man with hemophilia B and oculocutaneous albinism. RESULTS: The patient was diagnosed with hemophilia B at age 4months due to recurrent soft tissue bleeding episodes, and he was also diagnosed with Hermansky-Pudlak syndrome at 32years of age due to unexplained oculocutaneous albinism...
November 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27620887/cardiac-electrical-and-structural-changes-during-bacterial-infection-an-instructive-model-to-study-cardiac-dysfunction-in-sepsis
#10
Michael A Makara, Ky V Hoang, Latha P Ganesan, Elliot D Crouser, John S Gunn, Joanne Turner, Larry S Schlesinger, Peter J Mohler, Murugesan V S Rajaram
BACKGROUND: Sepsis patients with cardiac dysfunction have significantly higher mortality. Although several pathways are associated with myocardial damage in sepsis, the precise cause(s) remains unclear and treatment options are limited. This study was designed to develop a new model to investigate the early events of cardiac damage during sepsis progression. METHODS AND RESULTS: Francisella tularensis subspecies novicida (Ft.n) is a Gram-negative intracellular pathogen causing severe sepsis syndrome in mice...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27604661/clinical-interaction-between-diabetes-duration-and-aortic-stiffness-in-type-2-diabetes-mellitus
#11
D Agnoletti, A S Mansour, Y Zhang, A D Protogerou, S Ouerdane, J Blacher, M E Safar
Diabetes complications increase with disease duration. No study was performed on the relationship between aortic stiffness and diabetes duration, taking into account the respective influence of such factors on macro- and microcirculation. In total, 618 subjects with type 2 diabetes (259 men) attending the Department of Internal Medicine of Tizi Ouzou Hospital (Algeria) were studied in collaboration with Hotel-Dieu Hospital (Paris, France). Brachial blood pressure (BP), anthropometric, clinical and biological data were evaluated...
September 8, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27599368/the-role-of-the-ratio-of-j-point-elevation-magnitude-and-r-wave-amplitude-on-the-same-ecg-lead-in-the-risk-stratification-of-subjects-with-early-repolarization-pattern
#12
Xu-Miao Chen, Cheng-Cheng Ji, Yun-Jiu Cheng, Li-Juan Liu, Wei-Qi Zhu, Ying Huang, Wei-Ying Chen, Su-Hua Wu
BACKGROUND: Just as high-risk populations for cardiac arrest exist in patients with Brugada syndrome or long QT syndrome, high-risk and low-risk populations for cardiac arrest also exist in patients with early repolarization pattern (ERP). HYPOTHESIS: Electrocardiographic (ECG) characteristics can aid the risk stratification of patients with ERP. METHODS: Electrocardiographic parameters such as magnitude of J-point elevation and J/R ratio were measured...
September 6, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27573707/dynamics-of-sensorimotor-cortex-activation-during-absence-and-myoclonic-seizures-in-a-mouse-model-of-juvenile-myoclonic-epilepsy
#13
Li Ding, Martin J Gallagher
OBJECTIVE: Generalized epilepsy syndromes often confer multiple types of seizures, but it is not known if these seizures activate separate or overlapping brain networks. Recently, we reported that mice with a juvenile myoclonic epilepsy mutation (Gabra1[A322D]) exhibited both absence and myoclonic generalized seizures. Here, we determined the time course of sensorimotor cortex activation and the spatial distribution of spike voltage during these two seizures. METHODS: We implanted Gabra1(+/A322D) mice with multiple electroencephalography (EEG) electrodes over bilateral somatosensory cortex barrel fields (S1) and anterior (aM1) and posterior (pM1) motor cortices and recorded absence seizures/spike-wave discharges (SWDs) and myoclonic seizures...
October 2016: Epilepsia
https://www.readbyqxmd.com/read/27559494/novel-therapeutic-strategies-for-the-management-of-ventricular-arrhythmias-associated-with-the-brugada-syndrome
#14
Bence Patocskai, Charles Antzelevitch
INTRODUCTION: Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome characterized by prominent J waves appearing as distinct coved type ST segment elevation in the right precordial leads of the ECG. It is associated with a high risk for sudden cardiac death. AREAS COVERED: We discuss 1) ECG manifestations of BrS which can be unmasked or aggravated by sodium channel blockers, febrile states, vagotonic agents, as well as tricyclic and tetracyclic antidepressants; 2) Genetic basis of BrS; 3) Ionic and cellular mechanisms underlying BrS; 4) Therapy involving devices including an implantable cardioverter defibrillator (ICD); 5) Therapy involving radiofrequency ablation; and 6) Therapy involving pharmacological therapy which is aimed at producing an inward shift in the balance of the currents active during phase 1 of the right ventricular action potential either by boosting calcium channel current (isoproterenol, cilostazol and milrinone) or by inhibition of transient outward current Ito (quinidine, bepridil and the Chinese herb extract Wenxin Keli)...
2015: Expert Opinion on Orphan Drugs
https://www.readbyqxmd.com/read/27552540/vascular-health-in-patients-in-remission-of-cushing-s-syndrome-is-comparable-to-that-in-bmi-matched-controls
#15
Maem Wagenmakers, Shpp Roerink, Tha Schreuder, T S Plantinga, S Holewijn, Dhj Thijssen, J W Smit, G A Rongen, A M Pereira, Ajm Wagenmakers, R T Netea-Maier, Armm Hermus
CONTEXT: In active Cushing's syndrome (CS), patients suffer from endothelial dysfunction and premature atherosclerosis. However, it is uncertain to what extent vascular health recovers after long-term remission. This is highly relevant as this topic relates to future development of cardiovascular disease. OBJECTIVE: To investigate whether micro- and macrovascular health is impaired after long-term remission of CS, in patients with no or adequately treated co-morbidities...
August 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27516456/novel-cpvt-associated-calmodulin-mutation-in-calm3-calm3-a103v-activates-arrhythmogenic-ca-waves-and-sparks
#16
Nieves Gomez-Hurtado, Nicole J Boczek, Dmytro O Kryshtal, Christopher N Johnson, Jennifer Sun, Florentin R Nitu, Razvan L Cornea, Walter J Chazin, Melissa L Calvert, David J Tester, Michael J Ackerman, Björn C Knollmann
BACKGROUND: Calmodulin (CaM) mutations are associated with severe forms of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). CaM mutations are found in 13% of genotype-negative long QT syndrome patients, but the prevalence of CaM mutations in genotype-negative CPVT patients is unknown. Here, we identify and characterize CaM mutations in 12 patients with genotype-negative but clinically diagnosed CPVT. METHODS AND RESULTS: We performed mutational analysis of CALM1, CALM2, and CALM3 gene-coding regions, in vitro measurement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, Ca handling, L-type Ca current, and action potential duration...
August 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27510854/t-wave-morphology-can-distinguish-healthy-controls-from-lqts-patients
#17
S A Immanuel, A Sadrieh, M Baumert, J P Couderc, W Zareba, A P Hill, J I Vandenberg
Long QT syndrome (LQTS) is an inherited disorder associated with prolongation of the QT/QTc interval on the surface electrocardiogram (ECG) and a markedly increased risk of sudden cardiac death due to cardiac arrhythmias. Up to 25% of genotype-positive LQTS patients have QT/QTc intervals in the normal range. These patients are, however, still at increased risk of life-threatening events compared to their genotype-negative siblings. Previous studies have shown that analysis of T-wave morphology may enhance discrimination between control and LQTS patients...
September 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27508764/-op-6a-01-renalase-in-children-with-glomerular-kidney-diseases
#18
P Skrzypczyk, M Panczyk-Tomaszewska, J Przychodzien, M Mizerska-Wasiak, E Kuzma-Mroczkowska, E Gorska, A Stelmaszczyk-Emmel
OBJECTIVE: Renalase is a protein produced mainly by kidneys. Renalase inactivates circulating catecholamines catalyzing process of their oxidation. Studies in adults with kidney disease suggest that renalase may play a role in pathogenesis of hypertension and target organ damage. The aim of the study was to assess level of renalase in children with glomerular kidney diseases and to find the relation between renalase level and clinical parameters in this group of patients. DESIGN AND METHOD: In 78 children (47 M, 31F) aged from 3...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508560/-op-8b-02-arterial-stiffness-in-patients-with-obstructive-sleep-apnea-syndrome-an-individual-meta-analysis-of-contributing-factors
#19
R Tamisier, J Borel, S Millasseau, L Galerneau, M Destors, M Perrin, J Pepin
OBJECTIVE: Obstructive sleep apnea syndrome (OSA) is associated with cardiovascular co-morbidities and increased mortality. Arterial stiffness, and more specifically its gold standard pulse wave velocity (PWV) is a recognized independent strong predictor of cardiovascular events and mortality. Several studies have shown that PWV is elevated in OSA patients and might be improved by treatment with continuous positive airway pressure. However the respective impact of traditional risk factors for elevated arterial stiffness on the relationship between OSA and PWV has not been evaluated...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27471366/silent-and-malignant-early-repolarization-syndrome-mimicking-hyper-acute-st-elevation-myocardial-infarction
#20
Weng-Chio Tam, Ming-Hsiung Hsieh, Yung-Kuo Lin, Jong-Shiuan Yeh
A 55-year-old male with underlying type 2 diabetes mellitus and hypertension presented at our emergency department with ventricular fibrillation-related cardiac arrest. Hyper-acute ST elevation myocardial infarction was the preliminary diagnosis by 12-lead electrocardiography, which simultaneously showed J point ST elevation and tall T waves. However, the echocardiography showed concentric left ventricle hypertrophy and preserved left ventricular systolic function with no regional wall motion abnormalities, and coronary angiography did not show any critical coronary artery lesion...
July 2016: Acta Cardiol Sin
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