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Plasma donation

Jessica Julia Falk, Martina Winkelmann, Dagmar Stöhr, Mira Alt, Hubert Schrezenmeier, Adalbert Krawczyk, Ramin Lotfi, Christian Sinzger
To improve the potency of anti-human cytomegalovirus (HCMV) immunoglobulin preparations, we intended to find elite neutralizers among 9000 HCMV-seropositive blood donors. We identified 2.6 % top neutralizers using a high throughput screening and further analyzed the 80 most effective plasmas for strain-independent activity. Of those, 58 were broadly neutralizing towards various HCMV strains and hence regarded "elite" neutralizers. All elite neutralizers were then analyzed concerning their effect on individual virus particles during entry...
April 19, 2018: Journal of Infectious Diseases
Adrian Post, Isidor Minović, Else van den Berg, Manfred L Eggersdorfer, Gerjan J Navis, Johanna M Geleijnse, Reinold O B Gans, Harry van Goor, Joachim Struck, Casper F M Franssen, Ido P Kema, Stephan J L Bakker
Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as renal transplant recipients (RTR). Hence, we aimed to assess sulfate reabsorption in kidney donors and RTR. Plasma and urinary sulfate were determined in 671 RTR and in 251 kidney donors. Tubular sulfate reabsorption (TSR) was defined as filtered load minus sulfate excretion and fractional sulfate reabsorption (FSR) was defined as 1-fractional excretion...
April 2018: Physiological Reports
Jonas Mengel-From, Mette E Rønne, Anting L Carlsen, Kristin Skogstrand, Lisbeth A Larsen, Qihua Tan, Lene Christiansen, Kaare Christensen, Niels H H Heegaard
We aim to examine if circulating micro-RNA and cytokine levels associate with dementia diagnosis and cognitive scores. To test our hypothesis, we use plasma donated from 48 monozygotic twin pairs in 1997 and 46 micro-RNAs and 10 cytokines were quantified using microfluidic RT-qPCR and multiplex solid-phase immunoassays, respectively. Micro-RNA and cytokine profiling were examined for associations with dementia diagnoses in a longitudinal registry study or with cognitive scores at baseline. Thirty-six micro-RNAs and all cytokines were detected consistently...
April 11, 2018: Journal of Alzheimer's Disease: JAD
Qian Xiao, Andriy Derkach, Steven C Moore, Wei Zheng, Xiao-Ou Shu, Fangyi Gu, Neil E Caporaso, Joshua N Sampson, Charles E Matthews
Introduction: Sleep plays an important role in cardiometabolic health. The sleep-wake cycle is partially driven by the endogenous circadian clock, which governs a range of metabolic pathways. The association between sleep and cardiometabolic health may be mediated by alterations of the human metabolome. Objectives: To better understand the biological mechanism underlying the association between sleep and health, we examined human plasma metabolites in relation to sleep duration and sleep timing...
May 2017: Metabolomics: Official Journal of the Metabolomic Society
Piet Meijer, Karin Kynde, Antonius M H P van den Besselaar, Marjan Van Blerk, Timothy A L Woods
BACKGROUND: This study was designed to obtain an overview of the analytical quality of the prothrombin time, reported as international normalized ratio (INR) and to assess the variation of INR results between European laboratories, the difference between Quick-type and Owren-type methods and the effect of using local INR calibration or not. In addition, we assessed the variation in INR results obtained for a single donation in comparison with a pool of several plasmas. METHODS: A set of four different lyophilized plasma samples were distributed via national EQA organizations to participating laboratories for INR measurement...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Y T Wang, T Y Chen, J Zhu, Y C Jiao, C F Qu
Objective: Incidence of primary liver cancer (PLC) in China is mostly related to chronic infection of hepatitis B virus (HBV). Qidong was one of the endemic areas with high incidence of PLC in China before 2000. We conducted a series of studies regarding on PLC etiological prevention during the past decades to develop better primary prevention strategies for PLC. Methods: Qidong Hepatitis B Intervention Study was conducted in 1983-1990. A total of 41 182 newborns were randomly assigned to vaccination group and 40 211 (97...
April 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Alexander Kaserer, Andreas Schedler, Alexander Jetter, Burkhardt Seifert, Donat R Spahn, Philipp Stein, Jan-Dirk Studt
INTRODUCTION:  Rivaroxaban (RXA) is a direct oral factor Xa (Xa) antagonist with a short half-life and a fast onset and offset of effect. Before elective surgery, discontinuation is recommended with an interval of at least > 24 hours. In clinical practice, this is, however, not always sufficient to achieve a residual RXA plasma concentration deemed appropriate for surgery, defined as ≤ 50 mcg/L. Our study aimed at identifying factors associated with a higher-than-expected residual RXA plasma concentration in a large group of real-life patients...
April 3, 2018: Thrombosis and Haemostasis
Lisa M Johnson, Thomas J Gniadek, Claudia S Cohn, Gary Bachowski, Amy B Karger
OBJECTIVE: This case report investigates an unusual hCG result in a woman who is not pregnant. PATIENT AND METHODS: A 43-year-old woman was admitted for recurrence of thrombotic thrombocytopenic purpura (TTP) and therapeutic plasma exchange (TPE) was initiated. Prior to transitioning the patient from TPE to immunosuppressive therapy, a serum qualitative hCG test was performed and was positive. Several etiologies for elevated hCG were considered and investigated, including heterophile antibody interference, endogenous hCG from pituitary or malignancy, and exogenous hCG...
March 26, 2018: Clinical Biochemistry
Julie H T Dang, Moon S Chen
BACKGROUND: Biospecimens from racially diverse groups are needed to advance cancer research. The Asian American Cancer Education Study was developed to increase the number and proportion of blood biospecimen donations from Asian Americans for cancer research. METHODS: The authors' targeted approach included 2 types of community engagement, in-reach (within institution to Asian American patients with cancer) and outreach (external to institution to the general Asian American community)...
April 1, 2018: Cancer
Josef Evers, Uwe Taborski
This article is based on a question of a colleague from North America how coagulation could be triggered between a donor's arm and a fistula needle during plasma donation (synonymous with donor plasmapheresis). The technique of venipuncture and citrate anticoagulation are described. Uncommon and rare problems such as prolonged bleeding, scarring, and thrombosis in plasma donors are discussed. If venous puncture and citrate: blood flow ratio at 1:16 are correctly performed, however, there will be no anticoagulation abnormalities due to plasma donation...
March 25, 2018: Journal of Clinical Apheresis
Gillian Cooper, Qunying Mao, Laura Crawt, Yiping Wang, Thomas Dougall, Peter Rigsby, Zhenglun Liang, Miao Xu, Philip Minor, Junzhi Wang, Javier Martin
Enterovirus A71 (EV71) is the major causative agent of severe and fatal hand, foot and mouth disease. There is plenty of evidence that EV71 has circulated widely in the Western Pacific Region for the last twenty years. Vaccines against EV71 are already available or under development. A collaborative study to establish the 1st WHO International Standard for anti-EV71 serum (Human) was conducted to ensure that methods used to measure the serum neutralizing activity or antibody levels against EV71 are accurate, sensitive and reproducible...
March 20, 2018: Biologicals: Journal of the International Association of Biological Standardization
You-Wen Tan, Yan Tao, Long-Gen Liu, Yun Ye, Xin-Bei Zhou, Li Chen, Cong He
AIM: To understand the prevalence of hepatitis C virus (HCV) infection in blood donors over a nearly 27-year interval and to explore the factors that affect the outcome of HCV infection. METHODS: A retrospective and cross-sectional study was conducted. The participants, mostly plasma donors, were selected from three administrative villages in the Jiangsu province in Eastern China. A questionnaire was administered among the villagers who had a history of blood donation from the late 1980s to the early 1990s...
March 21, 2018: World Journal of Gastroenterology: WJG
Natalia Vladimirovna Mesonzhnik, Natalia Moskaleva, Ksenia Shestakova, Ksenia Kurynina, Pavel Baranov, Natalia Gretskaya, Igor Serkov, Igor Lyubimov, Vladimir Bezuglov, Svetlana Appolonova
OBJECTIVE: Nitroproston is a novel prostaglandin-based compound modified by NO-donating groups with potential application in obstructive respiratory diseases such as asthma and obstructive bronchitis. Nitroproston have been extensively studied using various pharmacological models. Its biological stability is still uncertain. The main aim of the present study was to evaluate Nitroproston stability in vitro, as well as to identify and characterize its major biodegradation products. METHODS: The principal biodegradation products of Nitroproston were identified in vitro using liquid chromatography/ion trap - time-of-flight mass-spectrometry...
March 9, 2018: Drug Metabolism Letters
George B Schreiber, Roger Brinser, Marilyn Rosa-Bray, Zi-Fan Yu, Toby Simon
BACKGROUND: Whole blood and red blood cell (RBC) donors are at risk of iron deficiency. Since Source plasma (SP) donors have RBCs returned during apheresis, risk of iron depletion appears low. However, SP donors can donate frequently and assessment of frequent donor iron status is needed. STUDY DESIGN AND METHODS: A total of 1254 SP donors were enrolled in four frequency groups determined by donations in the prior 12 months: no donations and 1 to 24, 25 to 69, and 70 or more donations...
March 9, 2018: Transfusion
Naoya Shinohara, Chieko Matsumoto, Keiji Matsubayashi, Tadashi Nagai, Masahiro Satake
There are few reports on HIV-1 intra-host evolutionary rate in asymptomatic treatment-naïve patients. Here, the HIV-1 intra-host evolutionary rate was estimated based on HIV-1 RNA sequences from plasma samples of blood donors in Japan. Blood donors were assumed to have received no treatment for and have no symptoms of HIV-1 infection because they were healthy, and declared no risky behaviors of HIV-1 infection on a self-reported questionnaire or interview followed by donation. HIV-1 RNA was obtained from 85 plasma samples from 36 blood donors who donated blood multiple times and were HIV-1-positive...
March 7, 2018: Virus Genes
Elske M Brouwer-Brolsma, Diewertje Sluik, Cecile M Singh-Povel, Edith J M Feskens
Previous studies show associations between dairy product consumption and type 2 diabetes, but only a few studies conducted detailed analyses for a variety of dairy subgroups. Therefore, we examined cross-sectional associations of a broad variety of dairy subgroups with pre-diabetes and newly diagnosed type 2 diabetes (ND-T2DM) among Dutch adults. In total, 112 086 adults without diabetes completed a semi-quantitative FFQ and donated blood. Pre-diabetes was defined as fasting plasma glucose (FPG) between 5·6 and 6·9 mmol/l or HbA1c% of 5·7-6·4 %...
February 2018: British Journal of Nutrition
Carla Regina Bianchi Codo, Jamil Pedro de Siqueira Caldas, Rafaella Regina Alves Peixoto, Vitor Lacerda Sanches, Tamara Cristina Guiraldelo, Solange Cadore, Sérgio Tadeu Martins Marba
OBJECTIVE: To determine and compare the concentrations of electrolytes and minerals in three different types of maternal milk samples: term donor milk before pasteurization, term donor milk after pasteurization and raw milk of mothers of preterm newborns at bedside. METHODS: Descriptive cross-sectional study. Concentrations of calcium (Ca), phosphorous (P), magnesium (Mg), sodium (Na) and potassium (K) were measured in random samples of three human breast milk groups...
February 22, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Johan Ljungberg, Mikael Janiec, Ingvar A Bergdahl, Anders Holmgren, Johan Hultdin, Bengt Johansson, Ulf Näslund, Agneta Siegbahn, Tove Fall, Stefan Söderberg
Background -Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untreated AS is linked to high mortality. The aetiological background of AS is unknown. Previous human studies were typically based on case-control studies. Biomarkers identified in prospective studies could lead to novel mechanistic insights. Methods -Within a large population survey with blood samples obtained at baseline, 334 patients were identified that later underwent surgery for AS (median age (interquartile range) 59...
February 27, 2018: Circulation
Samyuktha Muralidharan Pillai, Petra Seebeck, Ralph Fingerhut, Ji Huang, Xiu-Fen Ming, Zhihong Yang, François Verrey
BACKGROUND: Uninephrectomy (UNX) is performed for various reasons, including kidney cancer or donation. Kidneys being the main site of l-arginine production in the body, we tested whether UNX mediated kidney mass reduction impacts l-arginine metabolism and thereby nitric oxide production and blood pressure regulation in mice. METHODS AND RESULTS: In a first series of experiments, we observed a significant increase in arterial blood pressure 8 days post-UNX in female and not in male mice...
February 25, 2018: Journal of the American Heart Association
Jessica M Khouri, Ruth N Motter, Stephen S Arnon
OBJECTIVES: We undertook an open-label, uncontrolled study of investigational recombinant botulinum vaccine for botulinum neurotoxin (BoNT) serotypes A and B (rBV A/B) to assess its safety and immunogenicity in healthy volunteers who had been previously immunized with investigational pentavalent botulinum toxoid. Study participants who wished to do so could donate their hyperimmune plasma for production of Human Botulism Immune Globulin Intravenous (BIG-IV, BabyBIG®). STUDY DESIGN: A single 0...
February 20, 2018: Vaccine
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