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https://www.readbyqxmd.com/read/27891624/quarantine-versus-pathogen-reduced-plasma-coagulation-factor-content-and-rotational-thromboelastometry-coagulation
#1
Oliver M Theusinger, David Goslings, Jan-Dirk Studt, Brigitte Brand-Staufer, Burkhardt Seifert, Donat R Spahn, Beat M Frey
BACKGROUND: Different types of fresh-frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine-stored plasma (qFFP) and plasma that was pathogen-reduced using blood-safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin-generation) potential (ETP). MATERIALS AND METHODS: Thirty-five samples of each type of FFP were analyzed using only male Blood Group O donors...
November 27, 2016: Transfusion
https://www.readbyqxmd.com/read/27861957/improved-donor-safety-in-high-volume-apheresis-collections
#2
Ralph R Vassallo, Marjorie D Bravo, Hany Kamel
BACKGROUND: Separators use 1960s sex-based nomograms to estimate apheresis donor blood volume and to calculate the 15% maximum extracorporeal and collection volumes. As US body habitus changes, proportional overestimation of the maximum safe collection volume may become clinically significant with large-volume collections. We correlated 2 years of vasovagal reaction (VVR) data with 148,416 Trima apheresis procedure parameters to identify trends. STUDY DESIGN AND METHODS: Only platelet/plasma with or without red blood cell (RBC) procedures yielded collection volumes of at least 900 mL with no saline replacement...
November 10, 2016: Transfusion
https://www.readbyqxmd.com/read/27861290/pathophysiological-trends-during-withdrawal-of-life-support-implications-for-organ-donation-after-circulatory-death
#3
Arjun Iyer, Hong Chee Chew, Ling Gao, Jeanette Villanueva, Mark Hicks, Aoife Doyle, Gayathri Kumarasinghe, Andrew Jabbour, Paul Cassius Jansz, Michael P Feneley, Richard P Harvey, Robert M Graham, Kumud K Dhital, Peter S Macdonald
BACKGROUND: Donation after circulatory death (DCD) provides an alternative pathway to deceased organ transplantation. Although clinical DCD lung, liver, and kidney transplantation are well established, transplantation of hearts retrieved from DCD donors has reached clinical translation only recently. Progress has been limited by concern regarding the viability of DCD hearts. The aim of this study was to document the pathophysiological changes that occur in the heart and circulation during withdrawal of life (WLS) support...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27798951/associations-between-adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-cancer-prevention-recommendations-and-biomarkers-of-inflammation-hormonal-and-insulin-response
#4
Fred K Tabung, Teresa T Fung, Jorge E Chavarro, Stephanie A Smith-Warner, Walter C Willett, Edward L Giovannucci
Adherence to the 2007 WCRF/AICR cancer prevention recommendations has been associated with lower cancer risk but the underlying biological mechanisms have not been elucidated. We utilized dietary and lifestyle data from 11,342 women in the Nurses' Health Study and 8,136 men in the Health Professionals Follow-up Study, to investigate associations between adherence scores and markers of inflammation, hormonal and insulin response. Two scores ranging from 0 to 3 were constructed to assess adherence to the energy balance-related recommendations (weight management, physical activity, energy density); and the plant, animal foods and alcohol intake recommendations; with higher scores indicating greater adherence...
October 31, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27797116/methods-to-decrease-blood-loss-during-liver-resection-a-network-meta-analysis
#5
REVIEW
Elisabetta Moggia, Benjamin Rouse, Constantinos Simillis, Tianjing Li, Jessica Vaughan, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: Liver resection is a major surgery with significant mortality and morbidity. Specialists have tested various methods in attempts to limit blood loss, transfusion requirements, and morbidity during elective liver resection. These methods include different approaches (anterior versus conventional approach), use of autologous blood donation, cardiopulmonary interventions such as hypoventilation, low central venous pressure, different methods of parenchymal transection, different methods of management of the raw surface of the liver, different methods of vascular occlusion, and different pharmacological interventions...
October 31, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27775049/a-high-throughput-microfluidic-approach-for-1000-fold-leukocyte-reduction-of-platelet-rich-plasma
#6
Hui Xia, Briony C Strachan, Sean C Gifford, Sergey S Shevkoplyas
Leukocyte reduction of donated blood products substantially reduces the risk of a number of transfusion-related complications. Current 'leukoreduction' filters operate by trapping leukocytes within specialized filtration material, while allowing desired blood components to pass through. However, the continuous release of inflammatory cytokines from the retained leukocytes, as well as the potential for platelet activation and clogging, are significant drawbacks of conventional 'dead end' filtration. To address these limitations, here we demonstrate our newly-developed 'controlled incremental filtration' (CIF) approach to perform high-throughput microfluidic removal of leukocytes from platelet-rich plasma (PRP) in a continuous flow regime...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27755546/metabolite-and-lipid-profiling-of-biobank-plasma-samples-collected-prior-to-onset-of-rheumatoid-arthritis
#7
Izabella Surowiec, Lisbeth Ärlestig, Solbritt Rantapää-Dahlqvist, Johan Trygg
OBJECTIVE: The early diagnosis of rheumatoid arthritis (RA) is desirable to install treatment to prevent disease progression and joint destruction. Autoantibodies and immunological markers pre-date the onset of symptoms by years albeit not all patients will present these factors, even at disease onset. Additional biomarkers would be of high value to improve early diagnosis and understanding of the process, leading to disease development. METHODS: Plasma samples donated before the onset of RA were identified in the Biobank of Northern Sweden, a collection within national health survey programs...
2016: PloS One
https://www.readbyqxmd.com/read/27742227/plasma-protein-timings-relative-contributions-of-storage-time-donor-age-and-donation-season
#8
Jose A Cancelas, Neeta Rugg
No abstract text is available yet for this article.
October 5, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27739151/feasibility-of-routine-ferritin-testing-for-donor-management-validation-of-delayed-processing-and-demonstration-of-within-donor-reproducibility-over-time
#9
Mars Stone, Donald Brambilla, Karla Murcia, Melanie Dimapasoc, Sherri Cyrus, Ritchard G Cable, Joseph E Kiss, Michael P Busch
BACKGROUND: Understanding the effect of delayed processing of whole blood on plasma ferritin will inform the feasibility of both routine ferritin testing in donors and clinical research study design. STUDY DESIGN AND METHODS: Whole blood tubes drawn from 16 donors were held at 4°C and centrifuged at 24-hour intervals to assess plasma ferritin concentration up to 5 days after draw. Intraindividual variation over time was measured in 21 healthy donors in blood samples collected weekly for 4 weeks and then at 12 weeks...
October 2016: Transfusion
https://www.readbyqxmd.com/read/27692606/blood-supply-during-japan-s-1995-hanshin-awaji-earthquake
#10
Yoshihiro Fujimori, Yoshihiro Bouike, Kenneth Nollet, Hitoshi Miki
On January 17, 1995, a magnitude 7.3 earthquake occurred in southern Hyogo Prefecture, a substantially urban area of Japan's main island, Honshu. Now known as the Hanshin-Awaji Earthquake, this disaster damaged or destroyed 639 686 houses and took 6434 lives. Within the disaster area, the Japanese Red Cross (JRC) Hyogo Blood Center had regional responsibilities for collecting, testing, processing, storing, and distributing blood components, including red blood cells (RBCs), fresh frozen plasma (FFP) and platelet concentrates (PLTs)...
October 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27677767/comparison-of-in%C3%A2-silico-electrochemical-in%C3%A2-vitro-and-in%C3%A2-vivo-metabolism-of-a-homologous-series-of-radio-fluorinated-%C3%AF-1-receptor-ligands-designed-for-positron-emission-tomography
#11
Christian Wiese, Eva Große Maestrup, Fabian Galla, Dirk Schepmann, Achim Hiller, Steffen Fischer, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Cornelius K Donat, Peter Brust, Lars Büter, Uwe Karst, Bernhard Wünsch
The imaging of σ1 receptors in the brain by fluorinated radiotracers will be used for the validation of σ1 receptors as drug targets as well as for differential diagnosis of diseases in the central nervous system. The biotransformation of four homologous fluorinated PET tracers 1'-benzyl-3-(ω-fluoromethyl to ω-fluorobutyl)-3H-spiro[2]benzofuran-1,4'-piperidine] ([(18) F]1-4) was investigated. In silico studies using fast metabolizer (FAME) software, electrochemical oxidations, in vitro studies with rat liver microsomes, and in vivo metabolism studies after application of the PET tracers [(18) F]1-4 to mice were performed...
September 28, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27663143/willingness-of-human-immunodeficiency-virus-positive-patients-to-donate-their-organs-for-transplantation-in-taiwan-a-cross-sectional-questionnaire-survey
#12
Y-C Lee, C-C Hung, A Cheng, W-C Liu, P-Y Wu, S-P Yang, J-Y Zhang, Y-Z Luo, H-Y Chang, H-Y Sun, S-C Chang
BACKGROUND: With the introduction of combination antiretroviral therapy (cART) that has significantly improved survival, human immunodeficiency virus (HIV)-positive patients may be potential organ donors to HIV-positive recipients in a few countries. Organ shortage remains a challenge for organ transplantation in Taiwan, where organ donation by HIV-positive patients remains prohibited by law. METHODS: We assessed the willingness of organ donation (should they be pronounced brain death, and the ban on HIV-positive organ donation be lifted) among HIV-positive patients who received regular HIV care at a university hospital in a cross-sectional survey between May and August 2015 with the use of an anonymous, self-administered questionnaire interview...
September 24, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27639598/both-the-h2s-biosynthesis-inhibitor-aminooxyacetic-acid-and-the-mitochondrially-targeted-h2s-donor-ap39-exert-protective-effects-in-a-mouse-model-of-burn-injury
#13
Akbar Ahmad, Csaba Szabo
Hydrogen sulfide (H2S) exerts beneficial as well as deleterious effects in various models of critical illness. Here we tested the effect of two different pharmacological interventions: (a) inhibition of H2S biosynthesis using the cystathionine-beta-synthase (CBS)/cystathionine-gamma-lyase (CSE) inhibitor aminooxyacetic acid (AOAA) and the mitochondrially targeted H2S donor [10-oxo-10-[4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy]decyl]triphenyl-phosphonium (AP39). A 30% body surface area burn injury was induced in anesthetized mice; animals were treated with vehicle, AOAA (10mg/kg i...
September 14, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27625581/serum-vitamin-b12-and-thyroid-hormone-levels-in-saudi-patients-with-multiple-sclerosis
#14
Fahd A Al-Khamis
OBJECTIVES: To determine the relationship between Vitamin B12 levels and thyroid hormones in patients with multiple sclerosis (MS). MATERIALS AND METHODS: One hundred and ten patients with MS were recruited for this study after Institutional Review Board approval. All patients signed a written informed consent form and donated a single blood sample. Plasma Vitamin B12 levels, triiodothyronine (T3), and thyroxine (T4) hormone levels were measured. Data were analyzed using the Statistical Package for Social Sciences (SPSS) software...
September 2016: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/27617996/lc-ms-supported-studies-on-the-in-vitro-metabolism-of-both-enantiomers-of-flubatine-and-the-in-vivo-metabolism-of-18-f-flubatine-a-positron-emission-tomography-radioligand-for-imaging-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors
#15
Friedrich-Alexander Ludwig, René Smits, Steffen Fischer, Cornelius K Donat, Alexander Hoepping, Peter Brust, Jörg Steinbach
Both enantiomers of [(18)F]flubatine are promising radioligands for neuroimaging of α4β2 nicotinic acetylcholine receptors (nAChRs) by positron emission tomography (PET). To support clinical studies in patients with early Alzheimer's disease, a detailed examination of the metabolism in vitro and in vivo has been performed. (+)- and (-)-flubatine, respectively, were incubated with liver microsomes from mouse and human in the presence of NADPH (β-nicotinamide adenine dinucleotide 2'-phosphate reduced tetrasodium salt)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27612895/evaluation-of-iron-store-by-serum-ferritin-in-healthy-blood-donors-of-bangladesh
#16
M M Hoque, S D Adnan, S Karim, M A Mamun, S Nandy, M A Faruki, K Islam
Iron stores in the body exist primarily in the form of ferritin. Small amounts of ferritin secreted into the plasma and plasma ferritin is positively correlated with the size of the total body iron stores. The present study conducted to determine the iron status using the serum ferritin level among healthy Bangladeshi blood donors. The present cross sectional study was conducted in the Department of Transfusion Medicine, Dhaka Medical College, Dhaka, Bangladesh from July 2011 to June 2012. Blood donor signed informed consent and has satisfactory pre-donation health assessment and satisfactory post-donation blood test results were included in the study...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27598734/lower-energy-levels-improve-visual-recovery-in-small-incision-lenticule-extraction-smile
#17
David Donate, Rozenn Thaëron
PURPOSE: To compare the visual outcomes with energy close to the plasma threshold and energy at the standard set-up in small incision lenticule extraction (SMILE). METHODS: This retrospective, non-randomized, consecutive clinical case series included 486 eyes of 243 patients who underwent SMILE and were subdivided into two groups depending on the laser energy settings: the standard energy group (164 eyes) using a laser cut energy index of 36 (180 nJ), and the plasma threshold group (322 eyes) using a cut energy index of 20 (100 nJ, close to plasma threshold)...
August 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27575746/extensive-genetic-diversity-of-hiv-1-in-incident-and-prevalent-infections-among-malaysian-blood-donors-multiple-introductions-of-hiv-1-genotypes-from-highly-prevalent-countries
#18
Wei Zhen Chow, Abdul Hamid Bon, Sheila Keating, Fread Anderios, Hazwan Abdul Halim, Yutaka Takebe, Adeeba Kamarulzaman, Michael P Busch, Kok Keng Tee
Transfusion-transmissible infections including HIV-1 continue to pose major risks for unsafe blood transfusions due to both window phase infections and divergent viruses that may not be detected by donor screening assays. Given the recent emergence of several HIV-1 circulating recombinant forms (CRFs) in high-risk populations in the Southeast Asia region, we investigated the genetic diversity of HIV-1 among the blood donors in Kuala Lumpur, Malaysia. A total of 211 HIV-positive plasma samples detected among 730,188 donations to the National Blood Centre between 2013 and 2014 were provided (90...
2016: PloS One
https://www.readbyqxmd.com/read/27564651/refining-the-risk-estimate-for-transfusion-transmission-of-occult-hepatitis-b-virus
#19
C R Seed, P Kiely, V C Hoad, A J Keller
BACKGROUND AND OBJECTIVES: We previously published a model to estimate the residual risk (RR) for occult hepatitis B infection (OBI) in the absence of universal anti-HBc testing. To incorporate new information on the epidemiology of OBI, we describe model refinements and estimate a more accurate HBV RR due to OBI in Australia. MATERIALS AND METHODS: In our original model, the OBI risk, p(OBI), was defined by the rate of 'non-detection' by the HBV DNA screening test in use, p(NAT non-detection), and the average infectivity of blood components from OBI donors, p(transmission)...
August 26, 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27557985/acceptability-of-hiv-testing-sites-among-rural-and-urban-african-americans-who-use-cocaine
#20
D Keith Branham, Tyrone F Borders, Katharine E Stewart, Geoffrey M Curran, Brenda M Booth
African Americans (AAs) who use cocaine in the Southern region of the U.S. have a relatively high risk of HIV and need for HIV testing. Among this group, those residing in rural areas may have less favorable opinions about common HIV testing sites, which could inhibit HIV testing. We examined rural/urban variations in their acceptability of multiple HIV testing sites (private physician clinic, local health department, community health center, community HIV fair, hospital emergency department, blood plasma donation center, drug abuse treatment facility, and mobile van or community outreach worker)...
August 24, 2016: AIDS and Behavior
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