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Plasma donation

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https://www.readbyqxmd.com/read/28802068/dietary-citrate-and-plasma-ionized-calcium-implications-for-platelet-donors
#1
Stefanie Haynes, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Linda Welch, Yong Zhao, Mindy Greene, Michelle Vauthrin, Robert Weinstein
BACKGROUND: Platelet donors receive 40 mmol or more of IV citrate anion during donation. When plasma ionized calcium ([Ca(2+) ]) falls by ∼20%, half of the donors report symptoms of hypocalcemic toxicity. Citrus juices contain clinically relevant amounts of citrate anion. We asked whether citrus juice can lower [Ca(2+) ] thus potentially contributing to hypocalcemic toxicity. METHOD: Six volunteers were given 20.4 mmol of citrate anion as grapefruit juice or orange juice...
August 12, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28800844/first-comparative-analysis-concerning-the-plasma-platelet-contamination-during-mnc-collection
#2
Hella Pfeiffer, Susanne Achenbach, Julian Strobel, Robert Zimmermann, Reinhold Eckstein, Erwin F Strasser
BACKGROUND AND OBJECTIVES: Monocytes can be cultured into dendritic cells with addition of autologous plasma, which is highly prone to platelet contamination due to the apheresis process. Since platelets affect the maturation process of monocytes into dendritic cells and might even lead to a diminished harvest of dendritic cells, it is very important to reduce the platelet contamination. A new collection device (Spectra Optia) was analyzed, compared to two established devices (COM.TEC, Cobe Spectra) and evaluated regarding the potential generation of source plasma...
July 13, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28795781/evaluation-of-the-use-of-shock-index-in-identifying-acute-blood-loss-in-healthy-blood-donor-dogs
#3
Erin E McGowan, Kimberly Marryott, Kenneth J Drobatz, Erica L Reineke
OBJECTIVE: To determine if shock index (SI) would increase following blood donation and if it would be a more sensitive assessment of acute blood loss as compared with heart rate (HR), blood pressure, and plasma lactate. DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: Twenty client-owned clinically normal dogs. INTERVENTIONS: Peripheral venous blood measurements and blood donation...
August 10, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28793014/selective-malaria-antibody-screening-among-eligible-blood-donors-in-jiangsu-china
#4
Hong Lin, Shaowen Zhu, Shengjiang Zhu, Lei Shao, Nan Zhu, Chengyin Huang, Jun Sun
The risk of transfusion-transmitted malaria is a major concern in many countries. This study investigated the prevalence of malaria antibodies and parasitemia in eligible blood donors in Jiangsu, in Eastern China. Malaria antibodies were detected in 2.13% of the 704 plasma samples studied. We found that the prevalence of malaria antibodies was not significantly correlated with gender, occupation and frequency of donation, but it increased with age. No Plasmodium was observed in red blood cells and no Plasmodium DNA was detected in any of the antibody-positive samples...
August 7, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28792109/interface-engineering-of-perovskite-solar-cells-with-air-plasma-treatment-for-improved-performance
#5
Xiao Ma, Peng Tang, Dong Liu, Lili Wu, Jingquan Zhang, Lianghuan Feng
For high-efficiency perovskite solar cells (PSCs), interface engineering becomes critical for carrier collection from active perovskite material to the transport layer. To enhance power conversion efficiency (PCE), here we demonstrate a novel method named surface plasma treatment on mesoporous TiO2 electron transport layer (ETL) to improve electron extraction and transport properties at the perovskite/TiO2 interface. According to the XPS results, the plasma treatment induced a partial reduction of Ti4+ to Ti3+ within the TiO2 lattice and increased the concentration of oxygen vacancy on the TiO2 surface...
August 9, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28763920/-an-analysis-of-factors-associated-with-timeliness-of-antiretroviral-therapy-initiation-among-newly-diagnosed-hiv-aids-from-2010-to-2014-in-china
#6
H L Tang, J Xu, J Han, J Li, Y R Mao
Objective: To analyze timeline of antiretroviral therapy (ART) initiation among newly diagnosed HIV/AIDS from 2010 to 2014, as well as influencing factors. Methods: Data from the Chinese HIV/AIDS Comprehensive Response Information Management System was used to collect newly diagnosed HIV/AIDS cases from January 1, 2010 to December 31, 2014. Inclusion criteria of HIV/AIDS were confirmed cases and clinically diagnosed HIV positive, Chinese mainland cases, 14 years old and above, the first CD4(+)T lymphocyte ≤350 cells/μl in the follow up period...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28735922/prevalence-of-restless-legs-syndrome-and-associated-factors-in-an-otherwise-healthy-population-results-from-the-danish-blood-donor-study
#7
Maria Didriksen, Andreas S Rigas, Richard P Allen, Brendan J Burchell, Emanuele Di Angelantonio, Maria H Nielsen, Poul Jennum, Thomas Werge, Christian Erikstrup, Ole B Pedersen, Mie T Bruun, Kristoffer S Burgdorf, Erik Sørensen, Henrik Ullum
OBJECTIVE: Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by uncomfortable sensations in the legs. RLS often occurs as a comorbid condition. Besides an increased risk of iron deficiency, blood donors are considered to be generally healthy. Blood donors are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28732508/lysophosphatidic-acid-plasma-concentrations-in-healthy-subjects-circadian-rhythm-and-associations-with-demographic-anthropometric-and-biochemical-parameters
#8
Anna Michalczyk, Marta Budkowska, Barbara Dołęgowska, Dariusz Chlubek, Krzysztof Safranow
BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive lipid with a wide biological activity. Previous studies have shown its potential usefulness as a diagnostic marker for ovarian cancer. The aim of the study was to investigate which factors may influence plasma LPA concentrations in healthy subjects and to propose reference values. METHODS: The study group consisted of 100 healthy subjects. From all of them the blood samples were taken at 7 a.m. (fasting state)...
July 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28730708/evaluation-of-the-hypocholesterolemic-effect-and-prebiotic-activity-of-a-lentil-lens-culinaris-medik-extract
#9
Maria Vittoria Micioni Di Bonaventura, Cinzia Cecchini, Pilar Vila Donat, Giovanni Caprioli, Carlo Cifani, Maria Magdalena Coman, Alberto Cresci, Dennis Fiorini, Massimo Ricciutelli, Stefania Silvi, Sauro Vittori, Gianni Sagratini
SCOPE: the aim of our work was to produce a hydroalcoholic extract of lentils and to examine: a) the hypocholesterolemic action in an animal model, by studying the plasma cholesterol level and the concentration of bile acids in the faeces; b) the potential prebiotic effect, by conducting an in vitro culture fermentation experiment and assessing the level of short chain fatty acids (SCFAs) in the faeces of rats. METHODS AND RESULTS: Lentil extract (LE) was obtained by extracting lentils with a solution of H2 0/EtOH (70/30 v/v) for 3 h, and the content of main nutrients was determined...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28711704/detection-of-zikv-rna-in-semen-of-asymptomatic-blood-donors
#10
Didier Musso, Vaea Richard, Anita Teissier, Mars Stone, Marion C Lanteri, Geraldo Latoni, Jose Alsina, Rita Reik, Michael P Busch
OBJECTIVES: Zika virus (ZIKV) transmission through semen donation has never been reported but the risk is supported by the detection of ZIKV in semen and the demonstration of ZIKV sexual transmission. The potential impact of ZIKV on assisted reproductive procedures should be evaluated. METHODS: We tested longitudinally collected semen samples provided by asymptomatic blood donors who tested positive for ZIKV RNA in plasma during ZIKV outbreaks in Puerto Rico and Florida in 2016...
July 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28705549/-voluntary-and-non-remunerated-blood-donation-current-situation-and-perspectives
#11
M Monsellier
The voluntary and unpaid blood donation is recommended by all international authorities (WHO, Council of Europe, ISBT, EBA), because it represents the best way of aiming towards self-sufficiency in blood products of all kinds, while preserving an optimal level of quality and safety for recipients as for donors. Still infrequent in many developing countries it tends to develop. However, the objective assigned by the WHO to reach 100% of unpaid and voluntary blood donations in 2020 appears ambitious, in particular for the collection of plasma intended to the splitting industry...
July 10, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28677305/reasons-to-end-the-donor-career-a-quantitative-study-among-stopped-blood-donors-in-the-netherlands
#12
E F Klinkenberg, B Romeijn, W L de Kort, E-M Merz
BACKGROUND AND OBJECTIVES: Previous work has studied barriers to donating blood or plasma among current, lapsed and non-donors. Still, it remains unclear why donors stop donating and end their donor career voluntarily. A thorough understanding of why donors stop is necessary to develop more effective retention strategies and manage the decline in whole-blood donors. METHODS: An online questionnaire that contained questions about reasons to stop donation was sent out to 7098 Dutch whole-blood donors who deregistered from the donor pool in 2015 but who were not permanently deferred for medical reasons (response: N = 2490, 35%)...
July 5, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28673499/occult-hepatitis-b-infection-and-transfusion-transmission-risk
#13
D Candotti, L Boizeau, S Laperche
Advances in serology and viral nucleic acid testing (NAT) over the last decades significantly reduced the risk of transfusion-transmitted hepatitis B virus (HBV). The combination of HBsAg testing and NAT efficiently prevents the majority of HBV transmission. However, a specific residual risk remains associated with extremely low viral DNA levels in blood donors with occult HBV infection (OBI) that are intermittently or not detectable even by highly sensitive individual donation (ID) NAT. Studies have reported HBV transfusion-transmission with blood components from donors with OBI that contained low amount of viruses (<200 virions)...
June 30, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28655784/inhibition-of-megakaryocyte-differentiation-by-antibody-drug-conjugates-adcs-is-mediated-by-macropinocytosis-implications-for-adc-induced-thrombocytopenia
#14
Hui Zhao, Sara Gulesserian, Sathish Kumar Ganesan, Jimmy Ou, Karen Morrison, Zhilan Zeng, Veronica Robles, Josh Snyder, Lisa Do, Hector Aviña, Sher Karki, David R Stover, Fernando Doñate
Thrombocytopenia is a common adverse event in cancer patients treated with antibody-drug conjugates (ADCs), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and Trastuzumab emtansine (T-DM1). This study aims to elucidate the mechanism of action of ADC-induced thrombocytopenia. ENPP3 expression in platelets and megakaryocytes (MKs) was investigated and shown to be negative. The direct effect of AGS-16C3F on platelets was evaluated using platelet rich plasma following the expression of platelet activation markers...
June 27, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28653765/a-liquid-calcium-vitamin-d3-supplement-is-effective-prophylaxis-against-hypocalcemic-toxicity-during-apheresis-platelet-donation
#15
Robert Weinstein, Stefanie Haynes, Yong Zhao, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Molly Graves, Jeffrey A Bailey, Linda Welch, Amie Simard, Michelle Vauthrin, Mindy Greene
Hypocalcemic toxicity, because of return of citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of calcium carbonate, or of a liquid preparation containing calcium citrate, calcium phosphate, and vitamin D3 , would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral calcium carbonate at the start of, and every 20 minutes during, donation (P = 0...
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28645645/determinants-of-plasma-donation-a-review-of-the-literature
#16
A Beurel, F Terrade, J-P Lebaudy, B Danic
The major contribution of Human Sciences in the understanding of the whole blood donation behavior has been through the study of individuals' motivations and deterrents to donate. However, if whole blood donation has been very widely studied in the last sixty years, we still know very little about plasma donation in voluntary non-remunerated environments. Yet, the need for plasma-derived products has been strongly increasing for some years, and blood collection agencies have to adapt if they want to meet this demand...
June 20, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28637686/high-serum-phospholipid-dihomo-%C3%AE-linoleic-acid-concentration-and-low-%C3%AE-5-desaturase-activity-are-associated-with-increased-risk-of-type-2-diabetes-among-japanese-adults-in-the-hitachi-health-study
#17
Shamima Akter, Kayo Kurotani, Masao Sato, Takuya Hayashi, Keisuke Kuwahara, Yumi Matsushita, Tohru Nakagawa, Maki Konishi, Toru Honda, Shuichiro Yamamoto, Takeshi Hayashi, Mitsuhiko Noda, Tetsuya Mizoue
Background: The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish.Objective: The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults.Methods: We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study...
August 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28625206/organic-food-consumption-during-pregnancy-and-its-association-with-health-related-characteristics-the-koala-birth-cohort-study
#18
Ana Paula Simões-Wüst, Carolina Moltó-Puigmartí, Eugene Hjm Jansen, Martien Cjm van Dongen, Pieter C Dagnelie, Carel Thijs
OBJECTIVE: To investigate the associations of organic food consumption with maternal pre-pregnancy BMI, hypertension and diabetes in pregnancy, and several blood biomarkers of pregnant women. DESIGN: Prospective cohort study. SETTING: Pregnant women were recruited at midwives' practices and through channels related to consumption of food from organic origin. SUBJECTS: Pregnant women who filled in FFQ and donated a blood sample (n 1339)...
August 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28599950/changes-in-pre-and-post-donation-platelet-function-in-plateletpheresis-donors
#19
Q Zhou, X Yu, Y Cai, L Liu
OBJECTIVES: This study aimed to investigate the changes of platelet (PLT) function and coagulation time before and after plateletpheresis donation. MATERIAL AND METHODS: The healthy donors were divided into four groups according to the annual number of plateletpheresis donation: 20 times group, 15 times group, 10 times group and 5 times group. The healthy non-blood donors were selected as controls. The donation interval was 14 days. The blood samples were collected before plateletpheresis donation and after 30min, 7 d, and 14 d of donation for determination of coagulation time, PLT function, plasma protein, serum iron and blood routine change...
June 6, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28591470/cost-projections-for-implementation-of-safety-interventions-to-prevent-transfusion-transmitted-zika-virus-infection-in-the-united-states
#20
Katherine D Ellingson, Mathew R P Sapiano, Kathryn A Haass, Alexandra A Savinkina, Misha L Baker, Richard A Henry, James J Berger, Matthew J Kuehnert, Sridhar V Basavaraju
BACKGROUND: In August 2016, the Food and Drug Administration advised US blood centers to screen all whole blood and apheresis donations for Zika virus (ZIKV) with an individual-donor nucleic acid test (ID-NAT) or to use approved pathogen reduction technology (PRT). The cost of implementing this guidance nationally has not been assessed. STUDY DESIGN AND METHODS: Scenarios were constructed to characterize approaches to ZIKV screening, including universal ID-NAT, risk-based seasonal allowance of minipool (MP) NAT by state, and universal MP-NAT...
June 2017: Transfusion
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