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https://www.readbyqxmd.com/read/28543044/quantification-of-body-iron-and-iron-absorption-in-the-reds-ii-donor-iron-status-evaluation-rise-study
#1
Joseph E Kiss, Rebecca J Birch, Whitney R Steele, David J Wright, Ritchard G Cable
BACKGROUND: Repeated blood donation alters the iron balance of blood donors. We quantified these effects by analyzing changes in body iron as well as calculating iron absorbed per day for donors enrolled in a prospective study. STUDY DESIGN AND METHODS: For 1308 donors who completed a final study visit, we calculated total body iron at the enrollment and final visits and the change in total body iron over the course of the study. Taking into account iron lost from blood donations during the study and obligate losses, we also calculated the average amount of iron absorbed per day...
May 19, 2017: Transfusion
https://www.readbyqxmd.com/read/28542611/no-molecular-or-serological-evidence-of-zikavirus-infection-among-healthy-blood-donors-living-in-or-travelling-to-regions-where-aedes-albopictus-circulates
#2
Wegene Borena, Tamara Hofer, Karin Stiasny, Stephan W Aberle, Manfred Gaber, Dorothee von Laer, Harald Schennach
BACKGROUND: Previous studies have shown that Zika virus can infect and be transmitted by A. albopictus. The World Health organization (WHO) has raised concerns of autochthonous transmission of the virus in regions where the vector is endemic. The aim of this pilot study was to assess the occurrence of Zika virus (ZIKV) in western Austria (Tyrol) especially after a history of travel to A. albopictus endemic regions. METHODS: The study participants were healthy blood donors at randomly selected donation sites in the west Austrian region Tyrol...
2017: PloS One
https://www.readbyqxmd.com/read/28535684/metal-and-metal-oxide-interactions-and-their-catalytic-consequences-for-oxygen-reduction-reaction
#3
Qingying Jia, Shraboni Ghoshal, Jingkun Li, Wentao Liang, Guangnan Meng, Haiying Che, Shiming Zhang, Zi-Feng Ma, Sanjeev Mukerjee
Many industrial catalysts are composed of metal particles supported on metal oxides (MMO). It is known that the catalytic activity of MMO materials is governed by metal and metal oxide interactions (MMOI), but how to optimize MMO systems via manipulation of MMOI remains unclear, due primarily to the ambiguous nature of MMOI. Herein, we develop a Pt/NbOx/C system with tunable structural and electronic properties via a modified arc plasma deposition method. We unravel the nature of MMOI by characterizing this system under reactive conditions utilizing combined electrochemical, microscopy, and in situ spectroscopy...
May 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28525673/report-on-50-cases-of-severe-acute-hypotension-at-donor-plasmaphereses-treatment-and-course
#4
Josef Evers, George B Schreiber, Uwe Taborski
INTRODUCTION: This paper reports our experience in 50 cases with severe hypotensive reactions at plasma donations (synonymous with donor plasmaphereses). METHODS: Plasma donors who developed a severe acute hypotensive reaction at donor plasmapheresis, and were treated by placing the donor in the Trendelenburg position and rapid infusion of 1,000 mL saline were investigated. Plasmaphereses were performed with the Haemonetics® plasma collecting system 2 (PCS2). The results were analyzed using Excel...
May 19, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28483726/prevalence-of-igg-and-igm-anti-toxoplasma-gondii-antibodies-in-blood-donors-at-urmia-blood-transfusion-organization-iran
#5
Khosrow Hazrati Tappeh, Jalil Musavi, Mohammad Baradaran Safa, Hosein Galavani, Hamid Alizadeh
OBJECTIVE: The importance of toxoplasmosis lies in its global spread, opportunistic nature, and causative role in abortion or irreparable adverse effects on infants of infected pregnant women. Toxoplasma gondii has different transmission routes to humans, including blood transfusion. The objective of the present study was to evaluate the prevalence of IgG and IgM antibodies specific for T. gondii in blood donors at the Urmia Blood Transfusion Organization in west Azerbaijan, Iran. METHODS: The present analytical, descriptive study evaluated the plasma of 270 randomly selected blood bags donated in 2013...
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28476210/-not-for-profit-a-report-from-the-fourth-annual-symposium-of-ethics-held-by-the-national-institute-for-blood-transfusion-france
#6
J Ceccaldi, J-B Thibert, A Haddad, M-C Bouësseau, R Pottier, B Danic, S Noël, M Monsellier, J-D Tissot, T Sannié, B Clavier, M-F Mamzer, J-P Cartron, J-P Vernant, C Hervé, O Garraud
The not-for-profit issue has been debated in November 2016 in Paris; this issue is one of the four canonical pillars of ethical blood donation. It is intimately bound to benevolence though it is distinct, as not-for-profit calls for institutions while benevolence calls for individuals. It is indeed intended that voluntary blood donors do not benefit from their donation and are thus non-remunerated. Not-for-profit is essential since it refers to the public character of blood as a putative public resource aimed at being shared as a tribute of solidarity...
June 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28474406/analysis-of-rbc-microparticles-in-stored-whole-blood-bags-a-promising-marker-to-detect-blood-doping-in-sports
#7
Sven Christian Voss, Morana Jaganjac, Amna Mohamed Al-Thani, Jean Charles Grivel, Christophe Raynaud, Hind Al-Jaber, Afnan Saleh Al-Menhali, Zeyed Ahmad Merenkov, Mohammed Alsayrafi, Aishah Latiff, Costas Georgakopoulos
Blood doping in sports is prohibited by the World Anti-Doping Agency (WADA). To find a possible biomarker for the detection of blood doping, we investigated the changes in blood stored in CPDA-1 blood bags of eight healthy subjects who donated one unit of blood. Aliquots were taken on days 0, 14 and 35. Platelet free Plasma was prepared and stored at -80 °C until analysis on a flow cytometer dedicated for the analysis of Microparticles (MPs). Changes in the number of Red Blood Cell (RBC) -MPs were highly significant (p < 0...
May 4, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28469086/iron-accelerates-hemoglobin-oxidation-increasing-mortality-in-vascular-diseased-guinea-pigs-following-transfusion-of-stored-blood
#8
Jin Hyen Baek, Ayla Yalamanoglu, Yamei Gao, Ricardo Guenster, Donat R Spahn, Dominik J Schaer, Paul W Buehler
Non-transferrin-bound iron (NTBI) and free hemoglobin (Hb) accumulate in circulation following stored RBC transfusions. This study investigated transfusion, vascular disease, and mortality in guinea pigs after stored RBC transfusion alone and following cotransfusion with apo-transferrin (apo-Tf) and haptoglobin (Hp). The effects of RBC exchange transfusion dose (1, 3, and 9 units), storage period (14 days), and mortality were evaluated in guinea pigs with a vascular disease phenotype. Seven-day mortality and the interaction between iron and Hb as cocontributors to adverse outcome were studied...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28452395/temporary-impact-of-blood-donation-on-physical-performance-and-hematologic-variables-in-women
#9
Ida Stangerup, Nana L Kramp, Andreas K Ziegler, Flemming Dela, Karin Magnussen, Jørn Wulff Helge
BACKGROUND: No former studies have examined how blood donation influences physical performance in women, who due to menstruation may have a slower recovery of performance. Therefore, the aim of this study was to clarify how VO2peak , time trial (TT) performance, and hematologic variables are affected in 18 iron-sufficient (plasma ferritin [P-ferritin] > 30 µg/L) women after a standard 450-mL blood donation. STUDY DESIGN AND METHODS: VO2peak , TT performance, and blood variables were measured at baseline and 3, 7, 14, 21, and 28 days after blood donation in 18 iron-sufficient women...
April 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28449730/hepatitis-e-and-blood-donation-safety-in-selected-european-countries-a-shift-to-screening
#10
Dragoslav Domanović, Richard Tedder, Johannes Blümel, Hans Zaaijer, Pierre Gallian, Christoph Niederhauser, Silvia Sauleda Oliveras, Joan O'Riordan, Fiona Boland, Lene Harritshøj, Maria São José Nascimento, Anna Rita Ciccaglione, Constatina Politis, Cornelia Adlhoch, Benoit Flan, Wahiba Oualikene-Gonin, Guy Rautmann, Paul Strengers, Patricia Hewitt
The public health implications of hepatitis E virus (HEV) in Europe have changed due to increasing numbers of hepatitis E cases and recent reports of chronic, persistent HEV infections associated with progression to cirrhosis in immunosuppressed patients. The main infectious risk for such immunosuppressed patients is exposure to undercooked infected pork products and blood transfusion. We summarised the epidemiology of HEV infections among blood donors and also outlined any strategies to prevent transfusion-transmitted HEV, in 11 European countries...
April 20, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28438657/the-thiol-of-human-serum-albumin-acidity-microenvironment-and-mechanistic-insights-on-its-oxidation-to-sulfenic-acid
#11
Jenner Bonanata, Lucía Turell, Laura Antmann, Gerardo Ferrer-Sueta, Santiago Botasini, Eduardo Méndez, Beatriz Alvarez, E Laura Coitiño
Human serum albumin (HSA) has a single reduced cysteine residue, Cys34, whose acidity has been controversial. Three experimental approaches (pH-dependence of reactivity towards hydrogen peroxide, ultraviolet titration and infrared spectroscopy) are used to determine that the pKa value in delipidated HSA is 8.1 ± 0.2 at 37°C and 0.1M ionic strength. Molecular dynamics simulations of HSA in the sub-microsecond timescale show that while sulfur exposure to solvent is limited and fluctuating in the thiol form, it increases in the thiolate, stabilized by a persistent hydrogen-bond (HB) network involving Tyr84 and bridging waters to Asp38 and Gln33 backbone...
April 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#12
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28429125/low-plasma-homoarginine-concentration-is-associated-with-high-rates-of-all-cause-mortality-in-renal-transplant-recipients
#13
Arslan Arinc Kayacelebi, Isidor Minović, Erik Hanff, Anne-Roos S Frenay, Martin H de Borst, Martin Feelisch, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas
In renal transplant recipients (RTR), we recently found that low urinary excretion of homoarginine (hArg) is associated with mortality and graft failure. However, it is not known whether such prospective associations also hold true for plasma concentrations of hArg. In the present study, we therefore determined plasma concentrations of hArg in the same cohort, i.e. in 687 RTR (functioning graft ≥1 year), and in 140 healthy donors, before and after kidney donation. Plasma hArg concentrations were significantly lower in RTR compared to healthy controls [1...
April 20, 2017: Amino Acids
https://www.readbyqxmd.com/read/28377078/pathogen-safety-and-characterisation-of-a-highly-purified-human-alpha1-proteinase-inhibitor-preparation
#14
Scott Kee, David Weber, Birgit Popp, Thomas Nowak, Wolfram Schäfer, Albrecht Gröner, Nathan J Roth
Alpha1-proteinase inhibitor (A1PI) deficiency is a genetic condition predisposing to emphysema. Respreeza/Zemaira, a therapeutic preparation of A1PI, is prepared from human plasma. This article describes the purity and stability of Respreeza/Zemaira and the capacity of virus and prion reduction steps incorporated into its manufacturing process. Purity and stability of Respreeza/Zemaira were analysed using established methods. To test pathogen clearance capacity, high levels of test viruses/prions were spiked into aliquots of production intermediates and clearance studies were performed for selected manufacturing steps, under production and robustness conditions, using validated scale-down models...
April 1, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28370032/infectivity-of-blood-products-containing-cytomegalovirus-dna-results-of-a-lookback-study-in-nonimmunocompromised-patients
#15
Malte Ziemann, David Juhl, Christian Brockmann, Siegfried Görg, Holger Hennig
BACKGROUND: DNA of human cytomegalovirus (CMV) is frequently detected in plasma of donors with primary CMV infection. It is unknown, however, whether leukoreduced blood products from these donors contain sufficient amounts of infectious virus to cause transfusion-transmitted CMV infections (TT-CMV). STUDY DESIGN AND METHODS: During a 14-year period, CMV DNA-positive donations were identified as part of several previously published studies. Additionally, further donors with seroconversion were tested for CMV DNA...
March 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28336244/-commitment-in-plasmapheresis-donation-a-study-of-determinants-among-regular-donors-in-plasmapheresis
#16
S Delépine-Farvacques, Florence Terrade, B Danic, J-P Lebaudy
The purpose of this study, based on the Theory of planned behavior, is to identify and ultimately better understand what determines the fidelity and the regularity of donors committed in plasmapheresis donation. This qualitative study is a primary stage to establish a classification of donors in a French socio-cultural context. For this reason, we have carried out a survey among 16 regular plasmapheresis donors, by way of semi-structured individual interviews at the Établissement français du sang - Brittany...
June 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28333830/minimal-variation-in-anti-a-and-b-titers-among-healthy-volunteers-over-time-implications-for-the-use-of-out-of-group-blood-components
#17
Ulrik Sprogøe, Mark H Yazer, Mads Hvidkjær Rasmussen, Berit Antonsen, Claus Bistrup, Kristian Assing
BACKGROUND: Using potentially out-of-group blood components, like low titer A plasma and O whole blood, in the resuscitation of trauma patients is becoming increasingly popular. However, very little is known whether the donors' anti-A and/or anti-B titers change over time and whether repeated titer measurements on the same donor are required to ensure that each donation produces a low titer product. METHODS: The anti-A and/or anti-B titers were measured on 56 healthy adult volunteers (47 blood donors; nine blood center personnel) every 3 months for 12 consecutive months using an automated solid phase analyzer...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28329934/-hiv-infection-and-associated-factors-in-hiv-antibody-positive-clients-of-female-sex-workers-recently-reported-in-shaanxi-province
#18
T Hu, W H Chang, M Y Zhang
Objective: To investigate the current status of HIV infection and the related factors in HIV antibody positive clients of female sex workers (FSWs) recently reported in Shaanxi province. Methods: The HIV/AIDS cases newly diagnosed in males living in Shaanxi from January 1th of 2013 to June 30th of 2014 were selected and those infected through " commercial heterosexual behavior" were identified. The information about their demographic characteristics, previous unprotected heterosexual sex and the sample sources were collected, and serum or plasma samples were collected from them and tested with BED-CEIA...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28321111/relationships-between-clinical-self-reported-and-donation-specific-outcomes-a-prospective-follow-up-study-10-years-after-kidney-donation
#19
Käthe B Meyer, Anders Hartmann, Geir Mjøen, Marit H Andersen
BACKGROUND Long-term consequences of donor nephrectomy might be reduced kidney function, increased risk for cardiovascular disease, impaired quality of life, and fatigue. Few studies have investigated associations between clinical and self-reported outcomes in a long-term perspective. Thus, we aimed to investigate relationships between clinical, self-reported, and donation-specific outcomes in a nationwide cohort. MATERIAL AND METHODS We conducted a prospective follow-up study and assessed pre- and post-donation data from 202 donors who donated in 2001-2004...
March 21, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28316438/factors-affecting-the-quality-of-cryoprecipitate
#20
Rajeswari Subramaniyan, Neelam Marwaha, Ashish Jain, Jasmina Ahluwalia
BACKGROUND: Many variables affect the quality of cryoprecipitate (CRYO). We investigated the effect of freezing techniques and ABO blood groups on the quality of CRYO with respect to factor VIII: C and fibrinogen levels. MATERIALS AND METHODS: Ninety-six whole blood units each collected from in-house (Group I) and blood donation camps outside the hospital premises (Group II) were processed for CRYO preparation. Within each group, half the number of plasma units was frozen using blast freezer and another half using the conventional freezer...
January 2017: Asian Journal of Transfusion Science
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