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https://www.readbyqxmd.com/read/28422635/simulated-driving-skills-evaluation-of-teenagers-with-attention-deficit-hyperactivity-disorder-before-driving-lessons
#1
Navah Zelda Ratzon, Efrat Kadury Lunievsky, Arie Ashkenasi, Joseph Laks, Herman Avner Cohen
OBJECTIVE: We evaluated the driving skills of teenagers with attention deficit hyperactivity disorder (ADHD) during simulated driving before starting driving lessons and observed whether methylphenidate (MPH) affected their performance. METHOD: Sixty teenagers ages 15-18 yr were included; 29 teenagers with ADHD were tested with and without MPH, and 31 teenagers (control group) were tested once. All participants were tested on the STISIM Drive™ simulator. RESULTS: The number of center-line crossings was higher in the group without MPH treatment than in the control group and the MPH-treated group...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28420586/impaired-oral-absorption-of-methylphenidate-after-roux-en-y-gastric-bypass
#2
REVIEW
Carmil Azran, Peter Langguth, Arik Dahan
The anatomic and physiologic changes in the gastrointestinal (GI) tract after bariatric surgery may significantly affect the pharmacokinetics of medications taken by the patients for various reasons. Unfortunately, there is little information regarding changes in drug absorption after bariatric surgeries, limiting the ability of medical professionals to produce clear recommendations on what changes should be made to the formulations and dosing regimens of drugs after bariatric surgery. In this article, we report and analyze a case of 52-year-old male patient with morbid obesity and attention-deficit/hyperactivity disorder (ADHD) who experienced lack of methylphenidate efficacy after Roux en-Y gastric bypass (RYGB), which was eventually resolved by using the transdermal patch instead of an oral product...
March 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28417219/treatment-effect-of-methylphenidate-on-intrinsic-functional-brain-network-in-medication-na%C3%A3-ve-adhd-children-a-multivariate-analysis
#3
Jae Hyun Yoo, Dohyun Kim, Jeewook Choi, Bumseok Jeong
Methylphenidate is a first-line therapeutic option for treating attention-deficit/hyperactivity disorder (ADHD); however, elicited changes on resting-state functional networks (RSFNs) are not well understood. This study investigated the treatment effect of methylphenidate using a variety of RSFN analyses and explored the collaborative influences of treatment-relevant RSFN changes in children with ADHD. Resting-state functional magnetic resonance imaging was acquired from 20 medication-naïve ADHD children before methylphenidate treatment and twelve weeks later...
April 17, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28413936/processing-speed-can-monitor-stimulant-medication-effects-in-adults-with-attention-deficit-disorder-with-hyperactivity
#4
Niels Peter Nielsen, Elisabeth H Wiig, Svante Bäck, Jan Gustafsson
BACKGROUND: Treatment responses to methylphenidate by adults with ADHD are generally monitored against DSM-IV/DSM-V symptomatology, rating scales or interviews during reviews. AIMS: To evaluate the use of single- and dual-dimension processing-speed and efficiency measures to monitor the effects of pharmacological treatment with methylphenidate after a short period off medication. METHODS: A Quick Test of Cognitive Speed (AQT) monitored the effects of immediate-release methylphenidate in 40 previously diagnosed and medicated adults with ADHD...
May 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28412445/methylphenidate-effects-in-the-young-brain-friend-or-foe
#5
REVIEW
Sara Loureiro-Vieira, Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Soares Capela
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. Despite the proven therapeutic efficacy, concerns have been raised regarding the possible consequences of chronic MPH exposure during childhood and adolescence. Disturbances in the neurodevelopment at these crucial stages are major concerns given the unknown future life consequences...
April 12, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28400722/sex-differences-in-the-physiological-and-behavioral-effects-of-chronic-oral-methylphenidate-treatment-in-rats
#6
Lisa S Robison, Michalis Michaelos, Jason Gandhi, Dennis Fricke, Erick Miao, Chiu-Yim Lam, Anthony Mauceri, Melissa Vitale, Junho Lee, Soyeh Paeng, David E Komatsu, Michael Hadjiargyrou, Panayotis K Thanos
Methylphenidate (MP) is a psychostimulant prescribed for Attention Deficit Hyperactivity Disorder. Previously, we developed a dual bottle 8-h-limited-access-drinking-paradigm for oral MP treatment of rats that mimics the pharmacokinetic profile of treated patients. This study assessed sex differences in response to this treatment. Male and female Sprague Dawley rats were assigned to one of three treatment groups at 4 weeks of age (n = 12/group): Control (water), low dose (LD) MP, and high dose (HD) MP. Rats drank 4 mg/kg MP (LD) or 30 mg/kg MP (HD) during the first hour, and 10 mg/kg (LD) or 60 mg/kg MP (HD) for the remaining 7 h each day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28398816/the-possible-effect-of-methylphenidate-treatment-on-empathy-in-children-diagnosed-with-attention-deficit-hyperactivity-disorder-both-with-and-without-comorbid-oppositional-defiant-disorder
#7
Pavel Golubchik, Abraham Weizman
OBJECTIVE: To assess the Empathizing Quotient (EQ) of patients diagnosed with attention-deficit/hyperactivity disorder (ADHD) only or comorbid with oppositional defiant disorder (ODD) and compare the two groups' responses to methylphenidate (MPH) treatment. METHODS: Fifty-two children (8-18 years) diagnosed with ADHD, 26 of whom were also diagnosed with comorbid ODD (ADHD/ODD), were treated with MPH for 12 weeks. The level of EQ was assessed with the Children's version of the Empathizing Quotient (EQ-C) and the severity of ADHD symptoms with the ADHD Rating Scale (ADHD-RS)...
February 16, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28393639/the-safety-of-extended-release-drug-formulations-for-the-treatment-of-adhd
#8
Ann Childress
Attention-deficit/hyperactivity disorder (ADHD) is a complex neurobehavioral disorder affecting millions of patients worldwide. Effective treatments have been available for more than 60 years in the form of immediate-release (IR) stimulants However, stimulants have a high risk for abuse and are associated with adverse effects Including elevated blood pressure and heart rate, insomnia and decreased appetite. IR formulations also require multiple daily dosing. The search for improved safety, tolerability and convenience has led to the development of multiple extended-release (ER) stimulant and non-stimulant formulations...
April 10, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28388850/auditory-and-visual-executive-functions-in-children-and-response-to-methylphenidate-a-randomized-controlled-trial
#9
Yaffa Hadar, Shraga Hocherman, Oren Lamm, Emanuel Tirosh
OBJECTIVES: The aim of the study was to assess auditory and visually based executive functions (EFs) and the effect of methylphenidate (MPH) in children with ADHD. METHODS: Thirty-six boys between the ages of 8.3 and 9.7 years with ADHD and 36 matched controls were included. The study group was randomized into MPH and placebo for 7 days each in a crossover design. A Cued Choice Reaction Time (CCRT) test that included incongruent cuing was administered at baseline and following 1 and 2 weeks...
April 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28384334/correction-the-association-between-methylphenidate-treatment-and-the-risk-for-fracture-among-young-adhd-patients-a-nationwide-population-based-study-in-taiwan
#10
Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin
[This corrects the article DOI: 10.1371/journal.pone.0173762.].
2017: PloS One
https://www.readbyqxmd.com/read/28376888/daily-administration-of-yokukansan-and-keishito-prevents-social-isolation-induced-behavioral-abnormalities-and-down-regulation-of-phosphorylation-of-neuroplasticity-related-signaling-molecules-in-mice
#11
Hironori Fujiwara, Yaoyu Han, Ken Ebihara, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
BACKGROUND: Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (MPH), a drug used for attention deficit hyperactivity disorder (ADHD), suggesting that ISO mice offer a potential animal model of comorbid developmental disorder with ADHD and autism spectrum disorder symptoms. This study investigated the effects of Kampo formulae, yokukansan (YKS) and keishito (KST), on the neuropsychiatric symptoms of ISO mice to clarify the therapeutic or preventive/delaying potential of these formulae for the treatment of neurodevelopmental disorders...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#12
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children who is taking methylphenidate hydrochloride with Attention Deficit Hyperactivity Disorder. METHODS: Fifty seven consecutive patients who were diagnosed of Attention Deficit Hyperactivity Disorder (ADHD) and have been under oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) who have similar demographic features compared with the group 1, were involved as a control group...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28373837/living-in-the-fast-lane-evidence-for-a-global-perceptual-timing-deficit-in-childhood-adhd-caused-by-distinct-but-partially-overlapping-task-dependent-cognitive-mechanisms
#13
Ivo Marx, Steffen Weirich, Christoph Berger, Sabine C Herpertz, Stefan Cohrs, Roland Wandschneider, Jacqueline Höppner, Frank Häßler
Dysfunctions in perceptual timing have been reported in children with ADHD, but so far only from studies that have not used the whole set of timing paradigms available from the literature, with the diversity of findings complicating the development of a unified model of timing dysfunctions and its determinants in ADHD. Therefore, we employed a comprehensive set of paradigms (time discrimination, time estimation, time production, and time reproduction) in order to explore the perceptual timing deficit profile in our ADHD sample...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28371725/age-related-pharmacotherapy-of-attention-deficit-hyperactivity-disorder-in-slovenia-in-children-and-adolescents-a-population-based-study
#14
M Stuhec, I Locatelli
BACKGROUND: There are no data on age-related pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD) medication in children and adolescents in the most European countries. The main aim of this paper was to obtain that data for children and adolescents in Slovenia. METHOD: The number of ADHD drug prescriptions per patient was obtained from the health claims data on prescription drugs of the Health Insurance Institute of Slovenia for the study period (2003-2015)...
January 24, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28369788/model-based-approach-for-optimizing-study-design-and-clinical-drug-performances-of-extended-release-formulations-of-methylphenidate-for-the-treatment-of-adhd
#15
R Gomeni, Fmm Bressolle-Gomeni, T J Spencer, S V Faraone, L Fang, A Babiskin
Methylphenidate (MPH) is currently used to treat children with attention deficit hyperactivity disorder (ADHD). Several extended-release (ER) formulations characterized by a dual release process were developed to improve efficacy over an extended duration. In this study, a model-based approach using literature data was developed to: a) evaluate the most efficient pharmacokinetic (PK) model to characterize the complex PK profile of MPH ER formulations; b) provide PK endpoint metrics for comparing ER formulations; c) define criteria for optimizing development of ER formulations using a convolution-based model linking in-vitro release, in-vivo release and hour-by-hour behavioral ratings of ADHD symptoms; and d) define an optimized trial design for assessing the activity of MPH in pediatric populations...
March 29, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28368900/the-effect-of-methylphenidate-on-anxiety-and-depression-symptoms-in-patients-with-asperger-syndrome-and-comorbid-attention-deficit-hyperactivity-disorder
#16
Pavel Golubchik, Michal Rapaport, Abraham Weizman
The objective of this study was to assess the response of anxiety and depression symptoms to methylphenidate (MPH) treatment in patients with Asperger syndrome (AS) combined with attention deficit/hyperactivity disorder (ADHD). A group of 12 patients with AS/ADHD, aged 8-18 years, received 12 weeks of MPH treatment. The severities of ADHD, anxiety, and depression symptoms were assessed by means of the ADHD Rating Scale (ADHD-RS), Screen for Child Anxiety Related Emotional Disorders, and the Children's Depression Inventory...
March 31, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28367712/the-clinical-characteristics-of-adhd-diagnosed-in-adolescents-in-comparison-with-younger-children
#17
Muhammad Mahajnah, Rajech Sharkia, Nadeem Shorbaji, Nathanel Zelnik
OBJECTIVE: The aim of this study is to identify the clinical characteristics in adolescents newly diagnosed with ADHD. METHOD: Data of patients aged 7 to 17 years diagnosed with ADHD were collected and analyzed. The patients were divided into adolescents aged 13 to 17 years (Group I) and children aged 7 to 12 years (Group II): 592 males and 231 females. Group I consists of 450 participants, and Group II consists of 373 participants. RESULTS: Adolescents were predominantly inattentive (63...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28366111/safety-of-treatments-for-adhd-in-adults-pairwise-and-network-meta-analyses
#18
Danielly Chierrito de Oliveira, Patricia Guerrero de Sousa, Camila Borges Dos Reis, Fernanda Stumpf Tonin, Laiza Maria Steimbach, Suzane Virtuoso, Fernando Fernandez-Llimos, Roberto Pontarolo, Andréia Cristina Conegero Sanches
OBJECTIVE: The aim of the study was to analyze evidence comparing the profile of drugs used to treat ADHD in adult patients. METHOD: Systematic searches were conducted in electronic databases. Randomized, double-blind, parallel controlled trials that evaluated the safety of drugs in ADHD were included. The statistical analyses were conducted by pairwise meta-analyses and mixed treatment comparison (MTC). RESULTS: Ten ( n = 3006) trials were included in the analyses...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28351466/adhd-in-germany-trends-in-diagnosis-and-pharmacotherapy
#19
Christian J Bachmann, Alexandra Philipsen, Falk Hoffmann
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) sometimes persists into adulthood. There have been no studies from Germany until the present time on the diagnosis and treatment of ADHD over the course of patients' lives, in particular during the transition from adolescence to early adulthood. METHODS: We used nationwide routine data of the AOK statutory healthinsurance fund to determine the frequency of ADHD diagnoses and prescriptions of medication for ADHD...
March 3, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28351412/effect-of-pycnogenol%C3%A2-on-attention-deficit-hyperactivity-disorder-adhd-study-protocol-for-a-randomised-controlled-trial
#20
Annelies A J Verlaet, Berten Ceulemans, Helene Verhelst, Dirk Van West, Tess De Bruyne, Luc Pieters, Huub F J Savelkoul, Nina Hermans
BACKGROUND: Methylphenidate (MPH), the first choice medication for attention-deficit hyperactivity disorder (ADHD), is associated with serious adverse effects like arrhythmia. Evidence on the association of ADHD with immune and oxidant-antioxidant imbalances offers potential for antioxidant and/or immunomodulatory nutritional supplements as ADHD therapy. One small randomised trial in ADHD suggests, despite various limitations, therapeutic benefit from Pycnogenol®, a herbal, polyphenol-rich extract...
March 28, 2017: Trials
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