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methylphenidate adhd

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https://www.readbyqxmd.com/read/28817309/weight-height-and-body-mass-index-in-patients-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate
#1
Azucena Díez-Suárez, María Vallejo-Valdivielso, Juan J Marín-Méndez, Pilar de Castro-Manglano, César A Soutullo
OBJECTIVE: To describe the methylphenidate (MPH) effects on weight, height, and body mass index (BMI) in a Spanish sample diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHODS: Patients (6-18 years) diagnosed with ADHD treated at our Unit with MPH in the last 10 years were included in an observational longitudinal study. Weight, height, and BMI Z scores were measured at baseline and at last follow-up. RESULTS: Three hundred forty-two patients (mean [standard deviation] age: 10...
August 17, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28816913/influence-of-written-informed-consent-for-methylphenidate-on-medicine-persistence-rates-in-children-with-attention-deficit-hyperactivity-disorder
#2
Kristian Naenen-Hernani, Antonio Palazón-Bru, Francisco Colomina-Climent, Vicente F Gil-Guillén
OBJECTIVE: To assess the influence of written informed consent on nonpersistence with methylphenidate treatment in children with attention-deficit hyperactivity disorder (ADHD). METHODS: We undertook a cohort study including 141 children with ADHD who started treatment with methylphenidate, with a follow-up of 6 months. The main outcome variable was nonpersistence, defined as discontinuation of treatment by the patient. Two groups were analyzed with and without written informed consent...
August 9, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28811624/pupil-size-tracks-attentional-performance-in-attention-deficit-hyperactivity-disorder
#3
G Wainstein, D Rojas-Líbano, N A Crossley, X Carrasco, F Aboitiz, T Ossandón
Attention-deficit/hyperactivity disorder (ADHD) diagnosis is based on reported symptoms, which carries the potential risk of over- or under-diagnosis. A biological marker that helps to objectively define the disorder, providing information about its pathophysiology, is needed. A promising marker of cognitive states in humans is pupil size, which reflects the activity of an 'arousal' network, related to the norepinephrine system. We monitored pupil size from ADHD and control subjects, during a visuo-spatial working memory task...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807495/the-colorful-spectrum-of-tourette-syndrome-and-its-medical-surgical-and-behavioral-therapies
#4
Jan Roth
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28806385/a-naturalistic-comparison-of-methylphenidate-and-risperidone-monotherapy-in-drug-naive-youth-with-attention-deficit-hyperactivity-disorder-comorbid-with-oppositional-defiant-disorder-and-aggression
#5
Gabriele Masi, Azzurra Manfredi, Giulia Nieri, Pietro Muratori, Chiara Pfanner, Annarita Milone
BACKGROUND/PURPOSE: Attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) are frequently co-occurring in youth, but data about the pharmacological management of this comorbidity are scarce, especially when impulsive aggression is prominent. Although stimulants are the first-line medication for ADHD, second-generation antipsychotics, namely, risperidone, are frequently used. We aimed to assess effectiveness and safety of monotherapy with the stimulant methylphenidate (MPH) and risperidone in a consecutive sample of 40 drug-naive male youths diagnosed as having ADHD-combined presentation, comorbid with ODD and aggression, without psychiatric comorbidities, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version)...
August 10, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28800281/attentional-lapses-in-attention-deficit-hyperactivity-disorder-blank-rather-than-wandering-thoughts
#6
Charlotte Van den Driessche, Mikaël Bastian, Hugo Peyre, Coline Stordeur, Éric Acquaviva, Sara Bahadori, Richard Delorme, Jérôme Sackur
People with attention-deficit/hyperactivity disorder (ADHD) have difficulties sustaining their attention on external tasks. Such attentional lapses have often been characterized as the simple opposite of external sustained attention, but the different types of attentional lapses, and the subjective experiences to which they correspond, remain unspecified. In this study, we showed that unmedicated children (ages 6-12) with ADHD, when probed during a standard go/no-go task, reported more mind blanking (a mental state characterized by the absence of reportable content) than did control participants...
August 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28791048/specific-central-nervous-system-medications-are-associated-with-temporomandibular-joint-symptoms
#7
John K Drisdale Iii, Monica G Thornhill, Alexandre R Vieira
AIMS: There is evidence of association between bruxism and the increasingly common central nervous system stimulants prescribed for attention deficit hyperactivity disorder (ADHD), as well as the selective serotonin reuptake inhibitors (SSRIs) often prescribed for depression or anxiety. However, the evidence is not clear on whether these medications inducing bruxism are directly associated with temporomandibular joint disorder (TMD). The aim of this work is to evaluate whether these medications are associated with TMD symptoms...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28774371/-effect-of-baicalin-on-behavioral-characteristics-of-rats-with-attention-deficit-hyperactivity-disorder
#8
Rong-Yi Zhou, Xin-Min Han, Jiao-Jiao Wang, Hai-Xia Yuan, Ji-Chao Sun, Yue You, Yu-Chen Song
OBJECTIVE: To investigate the effect of baicalin on the behavioral characteristics of rats with attention deficit hyperactivity disorder (ADHD), and to provide a basis for further research on baicalin in the treatment of ADHD. METHODS: A total of 40 SHR rats were randomly divided into model group, methylphenidate hydrochloride (MPH) group, and low-, medium-, and high-dose baicalin groups, with 8 rats in each group. Eight WKY rats were selected as normal control group...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28762862/a-clinician-s-guide-to-adhd-treatment-options
#9
Gregory W Mattingly, Joshua Wilson, Anthony L Rostain
Attention deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition of children and adolescents that often persists into adulthood. Primary care physicians are commonly the first to diagnosis ADHD and initiate a treatment plan with the patient. Guidelines recommend psychostimulant treatment as a first-line therapy in the management plan because it has a substantial impact on alleviating the core symptoms of ADHD. The recent development of a variety of methylphenidate and amphetamine formulations provides many options to meet individual patient lifestyle needs...
August 1, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28761201/the-impact-of-methylphenidate-on-motor-performance-in-children-with-both-attention-deficit-hyperactivity-disorder-and-developmental-coordination-disorder-a-randomized-double-blind-crossover-clinical-trial
#10
Robabeh Soleimani, Maryam Kousha, Homa Zarrabi, Seyede Mahnaz Tavafzadeh-Haghi, Mir Mohammad Jalali
BACKGROUND: Children with attention deficit hyperactivity disorder/developmental coordination disorder (ADHD/DCD) suffer from problems associated with gross and fine motor skills. There is no effective pharmacological therapy for such patients. We aimed to assess the impact of methylphenidate (MPH) on motor performance of children with ADHD/DCD. METHODS: In this double-blind placebo-controlled, 17 children (12 boys) with ADHD/DCD with a mean age of 7 years 6 months were recruited in Shafa Hospital, Rasht, Iran...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28750831/potential-role-of-tyrosine-hydroxylase-in-the-loss-of-psychostimulant-effect-of-amphetamine-under-conditions-of-impaired-dopamine-transporter-activity
#11
Egle Janenaite, Valentina Vengeliene, Anton Bespalov, Berthold Behl
Amphetamine and methylphenidate are known to have stimulatory effect in healthy subjects but not in humans with attention deficit hyperactivity disorder and in rodents with impaired dopamine transporter (DAT) function. This phenomenon is called the paradoxical calming effect of psychostimulants. It has been previously demonstrated that psychostimulants may regulate the enzymatic activity of tyrosine hydroxylase (TH). Hence, the objective of the present study was to determine whether the lack of activity-stimulating effects of amphetamine in hyperactive rats is associated with changes in TH activity...
July 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28749241/considerations-for-adhd-in-the-child-with-epilepsy-and-the-child-with-migraine
#12
Jennifer Downs, Julianne Giust, David W Dunn
Attention Deficit Hyperactivity Disorder (ADHD) is a common comorbid condition in children with epilepsy and migraine. Treatment of ADHD in children with epilepsy or migraine is essential but clinicians may overlook symptoms of ADHD and avoid appropriate use of medications that may reduce symptoms of ADHD without compromising treatment of epilepsy or migraine. Areas covered: PubMed was searched for articles on ADHD and epilepsy or migraine. Key papers were reviewed for additional articles. Areas of interest were: epidemiology, etiological factors, and treatment with emphasis on therapy...
August 7, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28748725/recent-trends-in-the-prescribing-of-adhd-medications-in-canadian-primary-care
#13
Rachael Morkem, Scott Patten, John Queenan, David Barber
OBJECTIVE: The aim of this study was to describe the prevalence and incidence of ADHD medication prescribing, by age and gender, from 2005 to 2015 in Canadian primary care. METHOD: A population-based retrospective cohort study was conducted to evaluate the prescribing of ADHD medications between 2005 and 2015 using electronic medical record data. Yearly prevalence and incidence of ADHD medication prescribing were calculated for preschoolers (up to 5 years old), school-aged children (6-17 years old), and adults (18-65 years old) along with a description of the types of ADHD medications prescribed between 2005 and 2015...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28746699/association-of-risk-of-suicide-attempts-with-methylphenidate-treatment
#14
Kenneth K C Man, David Coghill, Esther W Chan, Wallis C Y Lau, Chris Hollis, Elizabeth Liddle, Tobias Banaschewski, Suzanne McCarthy, Antje Neubert, Kapil Sayal, Patrick Ip, Martijn J Schuemie, Miriam C J M Sturkenboom, Edmund Sonuga-Barke, Jan Buitelaar, Sara Carucci, Alessandro Zuddas, Hanna Kovshoff, Peter Garas, Peter Nagy, Sarah K Inglis, Kerstin Konrad, Alexander Häge, Eric Rosenthal, Ian C K Wong
Importance: Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, are the most common treatment for ADHD, but the association between their therapeutic use and suicide is unclear. Objective: To investigate the association between methylphenidate and the risk of suicide attempts. Design, Setting, and Participants: A population-based, electronic medical records database from the Hong Kong Clinical Data Analysis & Reporting System was used to identify 25 629 individuals aged 6 to 25 years who were treated with methylphenidate between January 1, 2001, and December 31, 2015...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28745107/effectiveness-of-psychotherapy-in-adult-adhd-what-do-patients-think-results-of-the-compas-study
#15
Vivien Groß, Caroline Lücke, Erika Graf, Alexandra P Lam, Swantje Matthies, Patricia Borel, Esther Sobanski, Michael Rösler, Wolfgang Retz, Christian Jacob, Michael Colla, Michael Huss, Thomas Jans, Bernhard Kis, Mona Abdel-Hamid, Ludger Tebartz van Elst, Alexandra Philipsen
OBJECTIVE: In the multicenter study Comparison of Methylphenidate and Psychotherapy in Adult ADHD (COMPAS), the efficacy of treatments has been primarily evaluated by observer-rated symptom change. Here, we additionally analyzed the patients' subjective evaluation of therapy effects. METHOD: COMPAS compared ADHD-specific group therapy with unspecific clinical management with/without concomitant pharmacotherapy in a four-armed design. Evaluation through the patients' retrospective perspective was performed after 1 year (post-treatment) and after another 1...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28740389/methylphenidate-dose-optimization-for-adhd-treatment-review-of-safety-efficacy-and-clinical-necessity
#16
REVIEW
Michael Huss, Praveen Duhan, Preetam Gandhi, Chien-Wei Chen, Carsten Spannhuth, Vinod Kumar
Attention-deficit/hyperactivity disorder (ADHD) is a chronic psychiatric disorder characterized by hyperactivity and/or inattention and is often associated with a substantial impact on psychosocial functioning. Methylphenidate (MPH), a central nervous system stimulant, is commonly used for pharmacological treatment of adults and children with ADHD. Current practice guidelines recommend optimizing MPH dosage to individual patient needs; however, the clinical benefits of individual dose optimization compared with fixed-dose regimens remain unclear...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28730282/blockade-of-%C3%AE-2-adrenergic-receptors-in-prelimbic-cortex-impact-on-cocaine-self-administration-in-adult-spontaneously-hypertensive-rats-following-adolescent-atomoxetine-treatment
#17
Britahny M Baskin, Bríd Á Nic Dhonnchadha, Linda P Dwoskin, Kathleen M Kantak
RATIONALE: Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood under a progressive ratio (PR) schedule. Compared to vehicle, chronic atomoxetine treatment during adolescence failed to increase cocaine self-administration under a PR schedule in adult SHR. OBJECTIVES: We determined if enhanced noradrenergic transmission at α2-adrenergic receptors within prefrontal cortex contributes to this neutral effect of adolescent atomoxetine treatment in adult SHR...
July 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28725548/age-dependent-lasting-effects-of-methylphenidate-on-the-gabaergic-system-of-adhd-patients
#18
Michelle M Solleveld, Anouk Schrantee, Nicolaas A J Puts, Liesbeth Reneman, Paul J Lucassen
Stimulants are the main pharmacological treatment for patients with attention-deficit/hyperactivity disorder (ADHD). Their current prescription rates are rising, both in children, adolescents and adults. Related to the impulse control phenotype, both preclinical and clinical studies have demonstrated lower γ-amino butyric acid (GABA) levels in prefrontal brain regions in ADHD. Whereas stimulant treatment increases GABA levels, preclinical studies have suggested that stimulant treatment effects may be age-dependent...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28719424/excessive-and-frequent-menstrual-bleeding-with-methylphenidate-in-an-adolescent-girl-with-attention-deficit-hyperactivity-disorder
#19
Murat Coskun, Ibrahim Adak
No abstract text is available yet for this article.
July 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28713515/effectiveness-of-methylphenidate-and-pufa-for-the-treatment-of-patients-with-adhd-a-double-blinded-randomized-clinical-trial
#20
Mahbobeh Firouzkouhi Moghaddam, Maryam Shamekhi, Tayebeh Rakhshani
BACKGROUND: In some children with ADHD, sub-optimal levels of various nutrients including PUFA especially omega-3 has been observed, and contradictory reports exist on the results of studies conducted on the positive therapeutic effects of PUFA in patients with ADHD. OBJECTIVE: The aim of this study was to investigate the effectiveness of methylphenidate and PUFA on treatment of patients with ADHD in Zahedan, Iran. METHODS: In this clinical trial, 40 children between 6 and 12 years of age with ADHD were investigated in Zahedan in 2014...
May 2017: Electronic Physician
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