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methylphenidate adhd

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https://www.readbyqxmd.com/read/29298167/newly-developed-skin-picking-after-methylphenidate-treatment-in-attention-deficit-hyperactivity-disorder-possible-mechanisms
#1
Tayfun Kara, İsmail Akaltun
Dermatillomania is characterized by excessive and repeated skin picking sufficient to damage cutaneous tissue, but with no underlying dermatological disease. The condition appears as an independent diagnosis in the Obsessive-Compulsive and Related Disorders category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. A psychiatric pathology is generally reported to accompany this symptom. Attention deficit hyperactivity disorder (ADHD) is a potentially lifelong condition involving inattentiveness, hyperactivity, and impulsiveness...
January 2, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29244542/differential-long-term-medication-impact-on-executive-function-and-delay-aversion-in-adhd
#2
Belen Rubio Morell, Sergio Hernández Expósito
The objective was to compare long-term effects of methylphenidate (MPH) and atomoxetine (ATX) on executive functions (EF) and delay aversion (DAv) in ADHD. A randomized controlled trial was conducted. A comprehensive neuropsychological battery was administered at three moments (Naive, Post-1, Post-2). ADHD participants who showed deficits in the naive evaluation (n = 26) were randomized to receive either MPH (n = 13; Mage = 11 ± 1, MIQ 96 ± 8) or ATX (n = 13; Mage = 10 ± 1, MIQ 106 ± 16...
December 15, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29238795/association-between-methylphenidate-and-amphetamine-use-in-pregnancy-and-risk-of-congenital-malformations-a-cohort-study-from-the-international-pregnancy-safety-study-consortium
#3
Krista F Huybrechts, Gabriella Bröms, Lotte Brix Christensen, Kristjana Einarsdóttir, Anders Engeland, Kari Furu, Mika Gissler, Sonia Hernandez-Diaz, Pär Karlsson, Øystein Karlstad, Helle Kieler, Anna-Maria Lahesmaa-Korpinen, Helen Mogun, Mette Nørgaard, Johan Reutfors, Henrik Toft Sørensen, Helga Zoega, Brian T Bateman
Importance: Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety. Objective: To examine the risk of congenital malformations associated with intrauterine exposure to stimulants. Design, Setting, and Participants: Cohort study of the Medicaid-insured population in the United States nested in the 2000-2013 US Medicaid Analytic eXtract, with follow-up of safety signals detected in the Medicaid Analytic eXtract data using the Nordic Health registries (2003-2013) (Denmark, Finland, Iceland, Norway, and Sweden)...
December 13, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29237331/autism-spectrum-disorder-consensus-guidelines-on-assessment-treatment-and-research-from-the-british-association-for-psychopharmacology
#4
Oliver D Howes, Maria Rogdaki, James L Findon, Robert H Wichers, Tony Charman, Bryan H King, Eva Loth, Gráinne M McAlonan, James T McCracken, Jeremy R Parr, Carol Povey, Paramala Santosh, Simon Wallace, Emily Simonoff, Declan G Murphy
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29236514/past-methylphenidate-exposure-and-stress-fractures-in-combat-soldiers-a-case-control-study
#5
Haggai Schermann, Ilan Shalom Ben-Ami, Adrian Tudor, Eyal Amar, Ehud Rath, Ran Yanovich
BACKGROUND: Previous research has revealed decreased bone mineral density (BMD) among children and adolescents who receive methylphenidate (MP) treatment for attention deficit hyperactivity disorder (ADHD). These findings have major clinical implications given that the prevalence of medication-treated ADHD is on the rise worldwide. We decided to investigate the clinical effect of MP exposure on the incidence of stress fractures, for which a low BMD is a risk factor. HYPOTHESIS: Exposure to MP is a risk factor for stress fractures...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29230023/pharmacogenetics-predictors-of-methylphenidate-efficacy-in-childhood-adhd
#6
N M Myer, J R Boland, S V Faraone
Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components influence the effects of ADHD treatment. Using meta-analysis, we sought to identify predictors of pharmacotherapy to further the clinical implementation of personalized medicine...
December 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29203337/shati-nat8l-knockout-mice-show-behavioral-deficits-ameliorated-by-atomoxetine-and-methylphenidate
#7
Kazuya Toriumi, Junko Tanaka, Takayoshi Mamiya, Tursun Alkam, Hyoung-Chun Kim, Atsumi Nitta, Toshitaka Nabeshima
We previously identified a novel molecule, SHATI/NAT8L, as having an inhibitory effect on methamphetamine dependence. We generated Shati/Nat8l knockout (KO) mice and found that they showed neurochemical changes and behavioral abnormalities related to attention deficit/hyperactivity disorder (AD/HD). In this study, we assessed validities of the Shati/Nat8l KO mice as a new animal model for AD/HD through a behavioral pharmacology approach. We conducted a locomotor activity test in a novel environment, a cliff avoidance test, and an object-based attention assay using Shati/Nat8l KO mice at the ages of 4 and 8 weeks...
December 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29192941/-response-with-methylphenidate-to-adhd-like-symptoms-in-pervasive-developmental-disorder-does-ces-1-enzyme-gene-polymorphism-have-a-role
#8
Ülkü Akyol Ardıç, Eyüp Sabri Ercan, Duygu Aygüneş, Deniz Yüce, Sibel Durak, Buket Kosova
OBJECTIVE: Methylphenidate is the first-choice medication for the Pervasive Developmental Disorders (PDDs), and comorbid Attention Deficit Hyperactivity Disorder (ADHD). But this approach generally results with poor outcomes, and increased adverse effects. It is aimed to investigate the comparison of cases who diagnosed with PDDs and Mild Mental Retardation (MR) and cases with pure ADHD in terms of the clinical response to MPH. Also we aimed to investigate the relations between CES-1 polymorphism gene and the clinical response to MPH...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29184845/the-effect-of-adding-ferrous-sulfate-to-methylphenidate-on-attention-deficit-hyperactivity-disorder-in-children
#9
Gholamreza Panahandeh, Bahareh Vatani, Parvin Safavi, Abolfazl Khoshdel
Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29182037/drd4-exon-3-genotype-and-adhd-randomized-pharmacodynamic-investigation-of-treatment-response-to-methylphenidate
#10
Darya Naumova, Natalie Grizenko, Sarojini M Sengupta, Ridha Joober
OBJECTIVES: Dopamine plays an important role in modulating attention and motor behaviors, dimensions altered in attention deficit/hyperactivity disorder (ADHD). Numerous association studies have linked dopamine receptor 4 (DRD4) to increased risk of ADHD. This study investigated the effect of DRD4 exon 3 polymorphism on child behaviours in response to treatment with methylphenidate (MPH). METHODS: 374 children diagnosed with ADHD (ages 6-12) were evaluated under three experimental conditions: baseline, placebo and MPH (0...
November 28, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29180967/efficacy-and-tolerability-of-different-interventions-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#11
Ruiling Luan, Zhiling Mu, Fang Yue, Shaoying He
Background: Our study is an analysis of multiple publications involving assessing the comparable efficacy and tolerability of six interventions, which are lisdexamfetamine dimesylate (LDX), atomoxetine (ATX), methylphenidate (MPH), clonidine hydrochloride (CLON), guanfacine extended release (GXR), and bupropion, for young patients (6-18 years old) suffering from attention deficit hyperactivity disorder (ADHD). Methods: A conventional meta-analysis (MA) was performed to give direct comparisons and a network meta-analysis (NMA) was used to show the combination of direct and indirect evidence...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29174864/a-multi-centre-randomised-double-blind-placebo-controlled-clinical-trial-of-methylphenidate-in-the-initial-treatment-of-acute-mania-memap-study
#12
Ulrich Hegerl, Roland Mergl, Christian Sander, Jens Dietzel, Istvan Bitter, Koen Demyttenaere, Ricardo Gusmão, Ana Gonzalez-Pinto Arrillaga, Iñaki Zorrilla, Adriana García Alocén, Victor Perez Sola, Eduard Vieta, Georg Juckel, Ulrich S Zimmermann, Michael Bauer, Pascal Sienaert, Sónia Quintão, Marc-Andreas Edel, Csilla Bolyos, Jose Luis Ayuso-Mateos, Pilar López-García, Michael Kluge
Based on many clinical and preclinical findings the 'vigilance regulation model of mania' postulates that an unstable regulation of wakefulness is a pathogenetic factor in both mania and Attention Deficit Hyperactivity Disorder (ADHD) and induces hyperactivity and sensation seeking as an autoregulatory attempt to stabilize wakefulness. Accordingly, stimulant medications with their vigilance stabilizing properties could have rapid antimanic effects similar to their beneficial effects in ADHD. The MEMAP study - a multi-center, double-blind, placebo-controlled and randomized clinical trial (RCT) - assessed the antimanic efficacy and safety of a 2...
November 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29172680/efficacy-and-safety-of-hld200-delayed-release-and-extended-release-methylphenidate-in-children-with-attention-deficit-hyperactivity-disorder
#13
Steven R Pliszka, Timothy E Wilens, Samantha Bostrom, Valerie K Arnold, Andrea Marraffino, Andrew J Cutler, Frank A López, Norberto J DeSousa, Floyd R Sallee, Bev Incledon, Jeffrey H Newcorn
OBJECTIVE: Evening-dosed HLD200 is a delayed-release and extended-release methylphenidate (DR/ER-MPH) formulation consisting of uniform, dual-layered microbeads with an inner drug-loaded core. DR/ER-MPH is designed to delay the initial release of drug by 8-10 hours, and thereafter, provide a controlled, extended drug release to target onset of effect upon awakening that lasts into the evening. This phase 3 study evaluated the safety and efficacy of DR/ER-MPH on symptoms and temporal at-home functional impairment in children with attention-deficit/hyperactivity disorder (ADHD)...
August 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29171685/slc6a3-polymorphism-and-response-to-methylphenidate-in-children-with-adhd-a-systematic-review-and-meta-analysis
#14
REVIEW
Robabeh Soleimani, Zivar Salehi, Soheil Soltanipour, Tolou Hasandokht, Mir Mohammad Jalali
Methylphenidate (MPH) is the most commonly used treatment for attention-deficit hyperactivity disorder (ADHD) in children. However, the response to MPH is not similar in all patients. This meta-analysis investigated the potential role of SLC6A3 polymorphisms in response to MPH in children with ADHD. Clinical trials or naturalistic studies were selected from electronic databases. A meta-analysis was conducted using a random-effects model. Cohen's d effect size and 95% confidence intervals (CIs) were determined...
November 24, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29169166/acupuncture-and-methylphenidate-drugs-in-adults-with-attention-deficit-hyperactivity-disorder-a-pilot-study-of-self-reported-symptoms
#15
Geir Ove Lystad, Berit Johannessen
No abstract text is available yet for this article.
November 17, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/29164079/cognitive-and-behavioral-disorders-in-children-with-neurofibromatosis-type-1
#16
REVIEW
Martha Milade Torres Nupan, Alberto Velez Van Meerbeke, Claudia Alejandra López Cabra, Paula Marcela Herrera Gomez
Aim: The last systematic review of research on the behavior of children with neurofibromatosis type 1 (NF1) was in 2012. Since then, several important findings have been published. Therefore, the study aim was to synthesize recent relevant work related to this issue. Method: We conducted a systematic review of the literature. Relevant articles were identified using the electronic databases PubMed, PsycINFO, and Scopus and a manual search of references lists. Thirty of 156 articles identified met the inclusion criteria...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29159857/methylphenidate-for-children-and-adolescents-with-autism-spectrum-disorder
#17
REVIEW
Nancy Sturman, Laura Deckx, Mieke L van Driel
BACKGROUND: Children with autistic spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD). The effectiveness of methylphenidate, a commonly used ADHD treatment, is therefore of interest in these children. OBJECTIVES: To assess the effects of methylphenidate for symptoms of ADHD (inattention, impulsivity and hyperactivity) and ASD (impairments in social interaction and communication, and repetitive, restricted or stereotypical behaviours) in children and adolescents aged 6 to 18 years with ASD...
November 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29131677/methylphenidate-has-superior-efficacy-over-parent-child-interaction-therapy-for-preschool-children-with-disruptive-behaviors
#18
Lianne van der Veen-Mulders, Barbara J van den Hoofdakker, Maaike H Nauta, Paul Emmelkamp, Pieter J Hoekstra
OBJECTIVE: To compare the effectiveness between parent-child interaction therapy (PCIT) and methylphenidate in preschool children with attention-deficit/hyperactivity disorder (ADHD) symptoms and disruptive behaviors who had remaining significant behavior problems after previous behavioral parent training. METHODS: We included 35 preschool children, ranging in age between 3.4 and 6.0 years. Participants were randomized to PCIT (n = 18) or methylphenidate (n = 17)...
November 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29129558/time-and-psychostimulants-opposing-long-term-structural-effects-in-the-adult-adhd-brain-a-longitudinal-mr-study
#19
Clara Pretus, J Antoni Ramos-Quiroga, Vanessa Richarte, Montse Corrales, Marisol Picado, Susanna Carmona, Óscar Vilarroya
Long-term effects of psychostimulants such as methylphenidate on ADHD patients have been proved to be difficult to capture in cross-sectional studies comparing medicated and non-medicated samples and in longitudinal studies with children, with age-related maturational processes possibly confounding independent effects of medication. However, chronic psychostimulant administration at therapeutic doses has been proven to yield profound neuroadaptive changes in rodent models. Here, we present for the first time the effect of psychostimulant treatment on brain volumes in a sample of medication-naïve adult ADHD patients...
November 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29125594/cotempla-xr-odt-another-long-acting-methylphenidate-for-adhd
#20
(no author information available yet)
No abstract text is available yet for this article.
November 6, 2017: Medical Letter on Drugs and Therapeutics
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