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methylphenidate adhd

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https://www.readbyqxmd.com/read/28328695/effect-of-biperiden-treatment-in-acute-orofacial-and-extremity-dyskinesia-with-methylphenidate-therapy
#1
Elif Acar Arslan, Erhan Arslan, Anil Kilinç, Özkan Göksu
Methylphenidate is a stimulant drug commonly prescribed to individuals with attention-deficit/hyperactivity disorder. The suggested underlying mechanism of acute dyskinesias is dopaminergic transmission increase. We describe a 9-year-old boy with a diagnosis of attention-deficit/hyperactivity disorder admitted to emergency clinic with primarily orofacial and extremity dyskinesia after administration of a first dose of 18 mg OROS (osmotic [controlled] release oral) methylphenidate (Concerta). OROS methylphenidate was discontinued, and the patient's symptoms resolved within 20 minutes after injection of biperiden by intravenous route (0...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28321605/long-term-effects-of-stimulant-exposure-on-cerebral-blood-flow-response-to-methylphenidate-and-behavior-in-attention-deficit-hyperactivity-disorder
#2
Anouk Schrantee, C Bouziane, E E Bron, S Klein, M A Bottelier, J J S Kooij, S A R B Rombouts, L Reneman
Stimulant prescription rates for attention deficit hyperactivity disorder (ADHD) are increasing, even though potential long-term effects on the developing brain have not been well-studied. A previous randomized clinical trial showed short-term age-dependent effects of stimulants on the DA system. We here assessed the long-term modifying effects of age-of-first-stimulant treatment on the human brain and behavior. 81 male adult ADHD patients were stratified into three groups: 1) early stimulant treatment (EST; <16 years of age) 2) late stimulant treatment (LST: ≥23 years of age) and 3) stimulant treatment naive (STN; no history of stimulant treatment)...
March 20, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28296941/the-association-between-methylphenidate-treatment-and-the-risk-for-fracture-among-young-adhd-patients-a-nationwide-population-based-study-in-taiwan
#3
Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin
Attention-deficit hyperactivity disorder (ADHD) is associated with higher risk for fracture. Whether the medical treatment for ADHD would mitigate the risk remains unclear. In this study, we sought to investigate the effect of methylphenidate treatment on risk for fracture, as well the moderational role of treatment duration on the risk of fracture, in a large national sample. Cases less than 18 years old were identified from Taiwan's National Health Insurance Research Database with a new primary diagnosis of ADHD (ICD-9:314) between 1996 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28293263/saikosaponin-a-alleviates-symptoms-of-attention-deficit-hyperactivity-disorder-through-downregulation-of-dat-and-enhancing-bdnf-expression-in-spontaneous-hypertensive-rats
#4
Sun Jichao, Han Xinmin, Ren Xianguo, Yin Dongqi, Zhou Rongyi, Lei Shuang, You Yue, Song Yuchen, Ying Jingnan
The disturbed dopamine availability and brain-derived neurotrophic factor (BDNF) expression are due in part to be associated with attention deficit hyperactivity disorder (ADHD). In this study, we investigated the therapeutical effect of saikosaponin a (SSa) isolated from Bupleurum Chinese DC, against spontaneously hypertensive rat (SHR) model of ADHD. Methylphenidate and SSa were orally administered for 3 weeks. Activity was assessed by open-field test and Morris water maze test. Dopamine (DA) and BDNF were determined in specific brain regions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28282463/family-based-association-study-of-drd4-gene-in-methylphenidate-responded-attention-deficit-hyperactivity-disorder
#5
Patrick Wing-Leung Leung, Janice Ka Yan Chan, Lu Hua Chen, Chi Chiu Lee, Se Fong Hung, Ting Pong Ho, Chun Pan Tang, Robert K Moyzis, James M Swanson
The 48-basepair (48-bp) variable number tandem repeat (VNTR) polymorphism in exon 3 of the dopamine receptor D4 gene (DRD4) is implicated in the etiology of attention-deficit/ hyperactivity disorder (ADHD). In particular, ADHD in European-ancestry population is associated with an increased prevalence of the 7-repeat (7R) allele of the exon 3 VNTR. However, it is intriguing to note that the 7R allele has been found to be of very low prevalence in the Chinese general population. In a previous case-control study, our research team had found that the 7R allele was similarly absent in Chinese ADHD children in Hong Kong...
2017: PloS One
https://www.readbyqxmd.com/read/28281767/the-effect-of-methylphenidate-oros-sup-%C3%A2-sup-on-the-narrative-ability-of-children-with-attention-deficit-hyperactivity-disorder
#6
Tessa L Rausch, Diane L Kendall, Sara T Kover, Elizabeth M Louw, Ursula L Zsilavecz, Anita Van der Merwe
BACKGROUND AND OBJECTIVE: Children with attention-deficit hyperactivity disorder (ADHD) experience difficulty with expressive language, including form (e.g. grammatical construction) and content (e.g. coherence). The current study aimed to investigate the effect of methylphenidate-Osmotic Release Oral System® (MPH-OROS®) on the narrative ability of children with ADHD and language impairment, through the analysis of microstructure and macrostructure narrative elements. METHOD: In a single group off-on medication test design, narratives were obtained from 12 children with ADHD, aged 7-13 years, using wordless picture books...
February 27, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28280346/trend-characteristics-and-pharmacotherapy-of-adults-diagnosed-with-attention-deficit-hyperactivity-disorder-a-nationwide-survey-in-taiwan
#7
Yu-Shian Cheng, Yu-Chiau Shyu, Sheng-Yu Lee, Shin-Sheng Yuan, Chun-Ju Yang, Kang-Chung Yang, Tung-Liang Lee, Liang-Jen Wang
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) in adults may result in functional impairment warranting clinical interventions. However, few studies have investigated the diagnosis and treatment rates of adult ADHD in non-Caucasian ethnic groups. This study used nationwide population-based data to investigate the rate of diagnosis, associated characteristics, and pharmacological treatment for adult ADHD in Taiwan. METHODS: Adults (age ≥18 years) newly diagnosed with ADHD (n=5,397) between January 2000 and December 2011 were enrolled from the National Health Insurance database in Taiwan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28277842/an-update-on-the-safety-of-psychostimulants-for-the-treatment-of-attention-deficit-hyperactivity-disorder
#8
Annabeth P Groenman, Lizanne J S Schweren, Andrea Dietrich, Pieter J Hoekstra
Methylphenidate is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). Although methylphenidate has a well-established evidence base for treating ADHD, its long-term benefits are unclear. Areas covered: Physical adverse effects, psychiatric adverse events and brain development Expert opinion: Some physical adverse events have been described (e.g. sleep disturbances, growth reduction, loss of appetite), although most are of transient nature. Psychiatric adverse events seem more related to the diagnosis ADHD itself, and not stimulant treatment...
March 9, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28274540/the-effect-of-metilpheniydate-risperidone-and-combination-therapy-on-ecg-in-children-with-attention-deficit-hyperactivity-disorder
#9
Derya Karpuz, Olgu Hallioglu, Fevziye Toros, Bahar Tasdelen
INTRODUCTION: This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy. METHODS: A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and combined therapy for minimum 3months and an untreated ADHD group (n=76) was consecutively included in the study. Twelve lead ECG parameters including mean QT, QTc, T-peak to T-end (TpTe) intervals, TpTe dispersion and TpTe/QT ratio were compared...
February 20, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28268188/-1-h-nmr-based-metabolomics-reveals-neurochemical-alterations-in-the-brain-of-adolescent-rats-following-acute-methylphenidate-administration
#10
Emmanuel Quansah, Victor Ruiz-Rodado, Martin Grootveld, Fay Probert, Tyra S C Zetterström
The psychostimulant methylphenidate (MPH) is increasingly used in the treatment of attention deficit hyperactivity disorder (ADHD). While there is little evidence for common brain pathology in ADHD, some studies suggest a right hemisphere dysfunction among people diagnosed with the condition. However, in spite of the high usage of MPH in children and adolescents, its mechanism of action is poorly understood. Given that MPH blocks the neuronal transporters for dopamine and noradrenaline, most research into the effects of MPH on the brain has largely focused on these two monoamine neurotransmitter systems...
March 6, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28260347/adhd-and-enuresis-a-study-about-effectiveness-of-treatment-with-methylphenidate-or-desmopressin-in-a-pediatric-population
#11
Pietro Ferrara, Valeria Sannicandro, Francesca Ianniello, Enrica Quattrocchi, Annamaria Sbordone, Tommasangelo Petitti, Paolo Mariotti
BACKGROUND: To evaluate the effectiveness of treatment with methylphenidate or desmopressin (dDAVP) in patients with comorbid ADHD and enuresis. METHODS: We enrolled 103 patients affected by ADHD and 125 patients with monosymptomatic nocturnal enuresis (NE). Data were collected between January 2014 and December 2015. The study was carried out in compliance with the Helsinki Declaration. RESULTS: About children with ADHD, 9/103 (8,7%) were also suffering from NE; of those 8/9 followed treatment with methylphenidate and cognitive behavioral therapy...
March 3, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28258319/comparative-efficacy-and-safety-of-attention-deficit-hyperactivity-disorder-pharmacotherapies-including-guanfacine-extended-release-a-mixed-treatment-comparison
#12
REVIEW
Alain Joseph, Rajeev Ayyagari, Meng Xie, Sean Cai, Jipan Xie, Michael Huss, Vanja Sikirica
This study compared the clinical efficacy and safety of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy in children and adolescents 6-17 years of age. A systematic literature review was conducted to identify randomized controlled trials (RCTs) of pharmacologic monotherapies among children and adolescents with ADHD. A Bayesian network meta-analysis was conducted to compare change in symptoms using the ADHD Rating Scale Version IV (ADHD-RS-IV), Clinical Global Impression-Improvement (CGI-I) response, all-cause discontinuation, and adverse event-related discontinuation...
March 3, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28256696/-current-state-of-the-attention-deficit-hyperactivity-disorder-approach-in-neuropediatrics
#13
E Cardo, G Ros-Cervera, J Eiris-Punal, C Escofet-Soteras, A Fernandez-Jaen, F Mulas, R Sanchez-Carpintero, A Sans, Grupo de Trabajo de Tdah de la Sociedad Espanola de Neurologia Pediatrica Grupo de Trabajo de Tdah de la Sociedad Espanola de Neurologia Pediatrica
AIM: To know the current state of the approach of attention deficit hyperactivity disorder (ADHD) in neuropediatricians. SUBJECTS AND METHODS: A telematic survey was carried out to collect preliminary information on the interest, difficulties in the management and treatment of ADHD to the 437 fellowship of the Neuropediactric Spanish Society (SENEP). RESULTS: Only 32.49% of the sent questionnaires were answered, with important geographic variability...
February 24, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28251031/olanzapine-induced-priapism-in-a-child-with-asperger-s-syndrome
#14
Hasan Bozkurt, Serkan Şahin
BACKGROUND: Priapism is a potentially painful and prolonged erection that occurs in the absence of any stimulation. Olanzapine has been reported to induce priapism in several adult cases with schizophrenia and/or mood disorders but very rarely reported in children. CASE REPORT: 9-year-old male with Asperger's Syndrome (AS) referred to our clinic with the complaints of inattention, hyperactivity and impulsivity. He was diagnosed with attention deficit hyperactivity disorder (ADHD) and given methylphenidate treatment which ameliorated his ADHD symptoms...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28243103/blood-pressure-and-anthropometry-in-children-treated-with-stimulants-a-longitudinal-cohort-study-with-an-individual-approach
#15
Magnus Landgren, Salmir Nasic, Mats Johnson, Trygve Lövoll, Daniel Holmgren, Elisabeth Fernell
BACKGROUND: Knowledge about the long-term effects on blood pressure (BP) and body mass index (BMI) when treating young patients for attention-deficit/hyperactivity disorder (AD/HD) with stimulants is limited. Most of the studies have reported mean and not individual values for anthropometrics and BP in treatment with stimulants. This seems to be the first study of changes based on the analyses of individual data measured over time. PATIENTS AND METHODS: Seventy young patients (aged 8-18 years) diagnosed with AD/HD and responding well to treatment with stimulants were followed for a mean period of 3 years and 3 months...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28241065/repeated-dexamphetamine-treatment-alters-the-dopaminergic-system-and-increases-the-phmri-response-to-methylphenidate
#16
Anouk Schrantee, Jordi L Tremoleda, Marzena Wylezinska-Arridge, Valentine Bouet, Peter Hesseling, Gideon F Meerhoff, Kora M de Bruin, Jan Koeleman, Thomas Freret, Michel Boulouard, Emilie Desfosses, Laurent Galineau, Alessandro Gozzi, François Dauphin, Willy Gsell, Jan Booij, Paul J Lucassen, Liesbeth Reneman
Dexamphetamine (AMPH) is a psychostimulant drug that is used both recreationally and as medication for attention deficit hyperactivity disorder. Preclinical studies have demonstrated that repeated exposure to AMPH can induce damage to nerve terminals of dopamine (DA) neurons. We here assessed the underlying neurobiological changes in the DA system following repeated AMPH exposure and pre-treated rats with AMPH or saline (4 times 5 mg/kg s.c., 2 hours apart), followed by a 1-week washout period. We then used pharmacological MRI (phMRI) with a methylphenidate (MPH) challenge, as a sensitive and non-invasive in-vivo measure of DAergic function...
2017: PloS One
https://www.readbyqxmd.com/read/28236285/cardiovascular-effects-of-stimulant-and-non-stimulant-medication-for-children-and-adolescents-with-adhd-a-systematic-review-and-meta-analysis-of-trials-of-methylphenidate-amphetamines-and-atomoxetine
#17
REVIEW
Leonie Hennissen, Mireille J Bakker, Tobias Banaschewski, Sara Carucci, David Coghill, Marina Danckaerts, Ralf W Dittmann, Chris Hollis, Hanna Kovshoff, Suzanne McCarthy, Peter Nagy, Edmund Sonuga-Barke, Ian C K Wong, Alessandro Zuddas, Eric Rosenthal, Jan K Buitelaar
BACKGROUND: Many children and adolescents with attention deficit/hyperactivity disorder (ADHD) are treated with stimulant and non-stimulant medication. ADHD medication may be associated with cardiovascular effects. It is important to identify whether mean group effects translate into clinically relevant increases for some individual patients, and/or increase the risk for serious cardiovascular adverse events such as stroke or sudden death. OBJECTIVES: To evaluate potential cardiovascular effects of these treatments, we conducted a systematic review and meta-analysis of the effects of methylphenidate (MPH), amphetamines (AMP), and atomoxetine (ATX) on diastolic and systolic blood pressure (DBP, SBP) and heart rate (HR) in children and adolescents with ADHD...
March 2017: CNS Drugs
https://www.readbyqxmd.com/read/28225747/effect-of-methylphenidate-on-emotional-dysregulation-in-children-with-attention-deficit-hyperactivity-disorder-oppositional-defiant-disorder-conduct-disorder
#18
Ayse Kutlu, Ulku Akyol Ardic, Eyup Sabri Ercan
BACKGROUND AND AIM: Emotional dysregulation (ED) is a frequent feature of attention-deficit/hyperactivity disorder (ADHD). It can be observed as a dysregulation profile or a deficient emotional self-regulation (DESR) profile. Oppositional defiant disorder/conduct disorder (ODD/CD) comorbidity is prevalent in ADHD and known to be related with ED. The first-line treatment of ADHD includes psychostimulants, but their effects on ED are not well studied. This study aimed to evaluate the outcomes of methylphenidate (MPH) treatment on ED in ADHD + ODD/CD cases...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28213188/children-with-adhd-and-symptoms-of-oppositional-defiant-disorder-improved-in-behavior-when-treated-with-methylphenidate-and-adjuvant-risperidone-though-weight-gain-was-also-observed-results-from-a-randomized-double-blind-placebo-controlled-clinical-trial
#19
Leila Jahangard, Shahrokh Akbarian, Mohammad Haghighi, Mohammad Ahmadpanah, Amir Keshavarzi, Hafez Bajoghli, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
Children with ADHD often show symptoms of oppositional defiant disorders (ODD). We investigated the impact of adjuvant risperidone (RISP) to a standard treatment with methylphenidate (MPH) in children with ADHD and symptoms of ODD. Eighty-four children with ADHD and ODD (age: M=8.55; range: 7.28-9.95 years; 73.8% males) took part in a double-blind, randomized, placebo-controlled, clinical trial lasting eight weeks. Participants were randomly assigned either to the MPH+RISP (1mg/kg/d+0.5mg/d) or to the MPH+PLCO (1mg/kg/d+placebo) condition...
December 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28212944/acute-and-long-term-effects-of-adolescent-methylphenidate-on-decision-making-and-dopamine-receptor-mrna-expression-in-the-orbitofrontal-cortex
#20
Leslie R Amodeo, Eliza Jacobs-Brichford, Matthew S McMurray, Jamie D Roitman
Though commonly used as a treatment for ADHD, the psychostimulant methylphenidate (MPH) is also misused and abused in adolescence in both clinical and general populations. Although MPH acts via pathways activated by other drugs of abuse, the short- and long-term effects of MPH on reward processing in learning and decision-making are not clearly understood. We examined the effect of adolescent MPH treatment on a battery of reward-directed behaviors both in adolescence during its administration and in adulthood after its discontinuation...
May 1, 2017: Behavioural Brain Research
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