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Omega-3 index

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https://www.readbyqxmd.com/read/28095913/effects-of-a-purified-krill-oil-phospholipid-rich-in-long-chain-omega-3-fatty-acids-on-cardiovascular-disease-risk-factors-in-non-human-primates-with-naturally-occurring-diabetes-type-2-and-dyslipidemia
#1
Petter-Arnt Hals, Xiaoli Wang, Yong-Fu Xiao
BACKGROUND: High serum levels of cholesterol, in particular low-density lipoprotein cholesterol, are considered a significant risk factor for development of cardiovascular disease. Therefore, rigorous treatment regimens with statins and other pharmaceuticals have been used extensively to reduce elevated cholesterol levels. Literature data have not clearly concluded whether long-chain omega-3 fatty acids reduce, increase or leave circulating cholesterol unaffected. In the present study a novel krill-oil derived preparation of omega-3 rich phospholipids, mainly phosphatidylcholine, was administered orally at increasing doses for 12 weeks to dyslipidemic non-human primates, and cholesterols and several other risk factors for cardiovascular disease were measured before, during and after treatment...
January 17, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28060063/oral-omega-3-fatty-acid-supplementation-for-laser-in-situ-keratomileusis-associated-dry-eye
#2
Parul Goyal, Arun K Jain, Chintan Malhotra
PURPOSE: To determine the effect of oral omega-3 fatty acid (ω3FA) supplementation in laser in situ keratomileusis (LASIK)-associated dry eye. METHODS: In this prospective, open-label study, patients undergoing LASIK were randomized to receive either 1.2 g/d of a triglyceride formulation of oral ω3FA (treatment group) or 400 mg/d vitamin E (control group) for 1 week before and continued for 12 weeks after surgery. Ocular surface disease index, tear breakup time, ocular surface staining, and Schirmer scores were evaluated and compared preoperatively and at 3 months after LASIK...
February 2017: Cornea
https://www.readbyqxmd.com/read/28042816/the-role-of-omega-3-polyunsaturated-fatty-acids-in-heart-failure-a-meta-analysis-of-randomised-controlled-trials
#3
Chunbin Wang, Bo Xiong, Jing Huang
Many new clinical trials about the effect of omega-3 polyunsaturated fatty acids (PUFAs) in heart failure (HF) patients have shown inconsistent results. Therefore, a meta-analysis of randomised controlled trials (RCTs) was performed to determine the benefits of omega-3 PUFAs in HF patients. Articles were obtained from PubMed, EMBASE, and the Cochrane Library. RCTs comparing omega-3 PUFAs with placebo for HF were included. Two reviewers independently extracted the data from the selected publications. The I² statistic was used to assess heterogeneity...
December 30, 2016: Nutrients
https://www.readbyqxmd.com/read/28040062/influences-of-dietary-omega-3-fatty-acids-on-haematologic-and-immunologic-changes-in-rainbow-trout-milked-regularly
#4
M E Yonar, K Koprucu
In this study, it was examined the effects of dietary omega-3 fatty acids on the haematocrit (Ht), haemoglobin (Hb), mean corpuscular haemoglobin (MCH), total protein (TP) and total immunoglobulin (TI) values, erythrocyte (RBC) and leucocyte (WBC) counts, mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), phagocytic index (PI) and nitroblue tetrazolium (NBT) activity in rainbow trout (Oncorhynchus mykiss) milked regularly. For this aim, one control and two experimental diets were prepared as isonitrogenous and isocaloric...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28027634/dietary-optimisation-with-omega-3-and-omega-6-fatty-acids-for-12-23-month-old-overweight-and-obese-children-in-urban-jakarta
#5
Fitrianna Cahyaningrum, Inge Permadhi, Muhammad Ridwan Ansari, Erfi Prafiantini, Purnawati Hustina Rachman, Rina Agustina
BACKGROUND AND OBJECTIVES: Diets with a specific omega-6/omega-3 fatty acid ratio have been reported to have favourable effects in controlling obesity in adults. However, development a local-based diet by considering the ratio of these fatty acids for improving the nutritional status of overweight and obese children is lacking. Therefore, using linear programming, we developed an affordable optimised diet focusing on the ratio of omega- 6/omega-3 fatty acid intake for obese children aged 12-23 months...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27988473/%C3%AE-tocopheryl-linolenate-solid-lipid-nanoparticles-for-the-encapsulation-protection-and-release-of-the-omega-3-polyunsaturated-fatty-acid-in-vitro-anti-melanoma-activity-evaluation
#6
Roberta Cassano, Silvia Mellace, Mariangela Marrelli, Filomena Conforti, Sonia Trombino
The main target of this study was the preparation, characterization and antioxidant activity evaluation of α-tocopheryl linolenate based solid lipid nanoparticles (SLNs-TL), able to incorporate omega-3 α-linolenic acid, useful for the treatment of melanoma, a type of skin cancer. In particular, α-linolenic acid was successfully derivatized with α-tocopherol and the obtained compound was characterized by Fourier transform infrared (FT-IR) and by (1)H NMR to confirm the ester linkage. Both the empty SLNs-TL that SLNs-TL-LIN, containing omega-3-linolenic acid, were prepared through the technique of the microemulsion...
December 10, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27973561/cross-classification-of-human-urinary-lipidome-by-sex-age-and-body-mass-index
#7
Kazuo Okemoto, Keiko Maekawa, Yoko Tajima, Masahiro Tohkin, Yoshiro Saito
Technological advancements in past decades have led to the development of integrative analytical approaches to lipidomics, such as liquid chromatography-mass spectrometry (LC/MS), and information about biogenic lipids is rapidly accumulating. Although several cohort-based studies have been conducted on the composition of urinary lipidome, the data on urinary lipids cross-classified by sex, age, and body mass index (BMI) are insufficient to screen for various abnormalities. To promote the development of urinary lipid metabolome-based diagnostic assay, we analyzed 60 urine samples from healthy white adults (young (c...
2016: PloS One
https://www.readbyqxmd.com/read/27941380/oral-omega-3-fatty-acid-supplementation-for-laser-in-situ-keratomileusis-associated-dry-eye
#8
Parul Goyal, Arun K Jain, Chintan Malhotra
PURPOSE: To determine the effect of oral omega-3 fatty acid (ω3FA) supplementation in laser in situ keratomileusis (LASIK)-associated dry eye. METHODS: In this prospective, open-label study, patients undergoing LASIK were randomized to receive either 1.2 g/d of a triglyceride formulation of oral ω3FA (treatment group) or 400 mg/d vitamin E (control group) for 1 week before and continued for 12 weeks after surgery. Ocular surface disease index, tear breakup time, ocular surface staining, and Schirmer scores were evaluated and compared preoperatively and at 3 months after LASIK...
December 8, 2016: Cornea
https://www.readbyqxmd.com/read/27940200/polyunsaturated-fatty-acids-and-suicide-risk-in-mood-disorders-a-systematic-review
#9
REVIEW
Maurizio Pompili, Lucia Longo, Giovanni Dominici, Gianluca Serafini, Dorian A Lamis, Jerome Sarris, Mario Amore, Paolo Girardi
Deficiency of omega-3 polyunsaturated fatty acids (PUFAs) and an alteration between the ratio of omega-3 and omega-6 PUFAs may contribute to the pathogenesis of bipolar disorder and unipolar depression. Recent epidemiological studies have also demonstrated an association between the depletion of PUFAs and suicide. Our aim was to investigate the relationship between PUFAs and suicide; assess whether the depletion of PUFAs may be considered a risk factor for suicidal behavior; in addition to detailing the potential use of PUFAs in clinical practice...
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27920821/protective-effect-of-vitamin-c-vitamin-b12-and-omega-3-on-lead-induced-memory-impairment-in-rat
#10
Saeedeh Alsadat Moosavirad, Mohammad Rabbani, Mohammad Sharifzadeh, Ali Hosseini-Sharifabad
Lead belongs to the heavy metal group and is considered as an environmental contaminant. Acute or chronic contact to lead can change the physiological function of human organs. One of the most important disorders following the lead exposure is neurotoxicity. Lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. The aim of the current study is to evaluate the possible protective effect of vitamin C (Vit C), vitamin B12 (Vit B12), omega 3 (ω-3), or their combination on the lead-induced memory disorder...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#11
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27880928/determination-of-red-blood-cell-fatty-acid-profiles-rapid-and-high-confident-analysis-by-chemical-ionization-gas-chromatography-tandem-mass-spectrometry
#12
Yvonne Schober, Hans Günther Wahl, Harald Renz, Wolfgang Andreas Nockher
Cellular fatty acid (FA) profiles have been acknowledged as biomarkers in various human diseases. Nevertheless, common FA analysis by gas chromatography mass spectrometry (GC-MS) requires long analysis time. Hence, there is a need for feasible methods for high throughput analysis in clinical studies. FA was extracted from red blood cells (RBC) and derivatized to fatty acid methyl esters (FAME). A method using gas chromatography tandem mass spectrometry (GC-MS/MS) with ammonia-induced chemical ionization (CI) was developed for the analysis of FA profiles in human RBC...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#13
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/27812381/associations-between-omega-fatty-acid-consumption-and-depressive-symptoms-among-individuals-seeking-behavioural-weight-loss-treatment
#14
Anna K Luke, E Whitney Evans, Dale S Bond, J Graham Thomas
OBJECTIVE: The typical Western diet is deficient in omega-3 and high in omega-6 fatty acids (FAs). These FAs may play a role in depressive symptoms via inflammatory processes, especially in the context of obesity, a pro-inflammatory state. This study investigated associations between omega-3 and omega-6 FA intake and depressive symptoms in adults seeking behavioural weight loss treatment (BWLT). METHODS: One hundred eighty-eight persons with overweight or obesity (83...
March 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27797641/effect-of-omega-3-fatty-acids-dietary-supplementation-on-ocular-surface-and-tear-film-in-diabetic-patients-with-dry-eye
#15
Constantine D Georgakopoulos, Olga E Makri, Dionisios Pagoulatos, Panagiotis Vasilakis, Politimi Peristeropoulou, Vasiliki Kouli, Maria I Eliopoulou, Caterina Psachoulia
OBJECTIVE: The objective of this study was to investigate the effect of dietary supplementation with omega-3 fatty acids on ocular surface and tear film in patients with type 2 diabetes suffering from dry eye. METHODS: Thirty-six patients suffering from type 2 diabetes and moderate to severe dry eye syndrome were included in the study. Patients were assigned to receive omega-3 long-chain polyunsaturated fatty acids for 3 months. Tear film break-up time test, Schirmer-I test, and conjunctival impression cytology analysis were performed on all patients at baseline and after 1 and 3 months...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27721230/potential-effects-of-omega-3-fatty-acids-on-insulin-resistance-and-lipid-profile-in-maintenance-hemodialysis-patients-a-randomized-placebo-controlled-trial
#16
Afshin Gharekhani, Simin Dashti-Khavidaki, Mahboob Lessan-Pezeshki, Mohammad-Reza Khatami
INTRODUCTION: Insulin resistance (IR), a risk factor for cardiovascular disease and all-cause mortality, is prevalent among maintenance hemodialysis patients. Effects of omega-3 fatty acids on IR in hemodialysis patients have not been well understood. This study aimed to determine the effects of omega-3 fatty acids on IR and serum lipids of hemodialysis patients. MATERIALS AND METHODS: Fifty-four adult patients on hemodialysis were randomly assigned to receive either 1800 mg of omega-3 fatty acids or placebo daily for 4 months...
September 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27701160/cognitive-impairment-is-associated-with-a-low-omega-3-index-in-the-elderly-results-from-the-kora-age-study
#17
Karoline Lukaschek, Clemens von Schacky, Johannes Kruse, Karl-Heinz Ladwig
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS: Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoic acid (omega-3 index) were measured in erythrocytes as a percentage of total fatty acids. The categories low (<5.7), intermediate (5.7-6.8), and high (>6...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27690699/serum-lipid-profile-and-fatty-acid-composition-of-erythrocyte-phospholipids-in-children-and-adolescents-with-primary-hyperlipidemia
#18
Valeria Deon, Cristian Del Bò, Federica Guaraldi, Giorgio Gargari, Andrea Bosusco, Paolo Simonetti, Patrizia Riso, Ornella Guardamagna
This study aimed at characterizing the fatty acid (FA) composition of red blood cell (RBC) phospholipids in children and adolescents with primary hyperlipidemia, and to ascertain potential association with serum lipid profile and dietary factors. At this purpose, 54 probands aged 6-17 years were recruited. Subjects showed a low omega-3 index (eicosapentaenoic acid, EPA + docosahexaenoic acid, DHA <4%). Compared to males, females had a trend toward lower levels of total monounsaturated fatty acids (MUFA) and MUFA/saturated fatty acids (SFAs) ratio in RBCs...
October 3, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27680989/do-%C3%AF-3-pufas-affect-insulin-resistance-in-a-sex-specific-manner-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Kylie A Abbott, Tracy L Burrows, Rohith N Thota, Shamasunder Acharya, Manohar L Garg
BACKGROUND: Evidence has suggested that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve obesity-induced insulin resistance (IR); however, results from human intervention trials have been equivocal. Recently it has been reported that n-3 PUFA status is inversely associated with type 2 diabetes in women but not in men, suggesting a sex-dependent effect. OBJECTIVE: We aimed to determine whether n-3 PUFA interventions affect IR in a sex-dependent manner. DESIGN: Five databases were searched (Medline, EMBASE, CINAHL, Scopus, and Pre-Medline) for randomized controlled trials...
November 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27651787/effects-of-omega-3-fatty-acid-in-nonalcoholic-fatty-liver-disease-a-meta-analysis
#20
Wenxia Lu, Sainan Li, Jingjing Li, Jianrong Wang, Rong Zhang, Yuqing Zhou, Qin Yin, Yuanyuan Zheng, Fan Wang, Yujing Xia, Kan Chen, Tong Liu, Jie Lu, Yingqun Zhou, Chuanyong Guo
A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, Science Citation Index (ISI Web of Science), Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant randomized controlled trials on the effects of n-3 polyunsaturated fatty acids (PUFAs) in patients with NAFLD from inception to May 2015...
2016: Gastroenterology Research and Practice
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