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Omega-3 index

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https://www.readbyqxmd.com/read/28629180/bioavailability-of-dietary-omega-3-fatty-acids-added-to-a-variety-of-sausages-in-healthy-individuals
#1
Anton Köhler, Johanna Heinrich, Clemens von Schacky
A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g (n = 22) daily for 8 weeks, or matching placebo sausages (n = 22)...
June 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28625107/associations-between-omega-3-fatty-acids-and-25-oh-d-and-psychological-distress-among-inuit-in-canada
#2
Hans-Ragnar Skogli, Dominique Geoffroy, Hope A Weiler, Grethe S Tell, Laurence J Kirmayer, Grace M Egeland
BACKGROUND: Inuit in Canada have experienced dietary changes over recent generations, but how this relates to psychological distress has not been investigated. OBJECTIVE: To evaluate how nutritional biomarkers are related to psychological distress. DESIGN: A total of 36 communities in northern Canada participated in the International Polar Year Inuit Health Survey (2007-2008). Of 2796 households, 1901 (68%) participated; 1699 Inuit adults gave blood samples for biomarker analysis and answered the Kessler 6-item psychological distress questionnaire (K6)...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28608804/phytosterols-and-omega-3-supplementation-exert-novel-regulatory-effects-on-metabolic-and-inflammatory-pathways-a-proteomic-study
#3
Carmen Lambert Judit Cubedo, Teresa Padró, Joan Sánchez-Hernández, Rosa M Antonijoan, Antonio Perez, Lina Badimon
Cardiovascular disease (CVD) remains one of the major causes of death and disability worldwide. In addition to drug treatment, nutritional interventions or supplementations are becoming a health strategy for CVD prevention. Phytosterols (PhyS) are natural components that have been shown to reduce cholesterol levels; while poly-unsaturated fatty acids (PUFA), mainly omega-3 (ω3) fatty acids, have shown to reduce triglyceride levels. Here we aimed to investigate whether the proteins in the main lipoproteins (low density lipoproteins (LDL) and high density lipoproteins (HDL)) as well as proteins in the lipid free plasma fraction (LPDP) were regulated by the intake of PhyS-milk or ω3-milk, in overweight healthy volunteers by a proteomic based systems biology approach...
June 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28595185/association-of-blood-fatty-acid-composition-and-dietary-pattern-with-the-risk-of-non-alcoholic-fatty-liver-disease-in-patients-who-underwent-cholecystectomy
#4
Poyoung Shim, Dongho Choi, Yongsoon Park
BACKGROUND/AIMS: The relationship between diet and non-alcoholic fatty liver disease (NAFLD) in patients with gallstone disease and in those who have a high risk for NAFLD has not been investigated. This study was conducted to investigate the association between the risk of NAFLD and dietary pattern in patients who underwent cholecystectomy. Additionally, we assessed the association between erythrocyte fatty acid composition, a marker for diet, and the risk of NAFLD. METHODS: Patients (n = 139) underwent liver ultrasonography to determine the presence of NAFLD before laparoscopic cholecystectomy, reported dietary intake using food frequency questionnaire, and were assessed for blood fatty acid composition...
June 9, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28569164/omega-3-fatty-acids-phenolic-compounds-and-antioxidant-characteristics-of-chia-oil-supplemented-margarine
#5
Muhammad Nadeem, Muhammad Imran, Imran Taj, Muhammad Ajmal, Muhammad Junaid
BACKGROUND: Chia (Salvia hispanica L.) is known as power house of omega fatty acids which has great health benefits. It contains up to 78% linolenic acid (ω-3) and 18% linoleic acid (ω-6), which could be a great source of omega-3 fatty acids for functional foods. Therefore, in this study, margarines were prepared with supplementation of different concentrations of chia oil to enhance omega-3 fatty acids, antioxidant characteristics and oxidative stability of the product. METHODS: Margarines were formulated from non-hydrogenated palm oil, palm kernel and butter...
May 31, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28550831/-relevance-of-omega-3-and-omega-6-omega-3-ratio-in-preventing-cognitive-impairment
#6
Belina Nunes, Cristina Pinho, Cláudia Sousa, Alan Rocha Melo, Narcisa Bandarra, Maria Carolina Silva
INTRODUCTION: The epidemiological and social relevance of dementia and mild cognitive impairment increases with life expectancy and prevalence of metabolic disorders. The recognition of an important role for dietary nutrients on cognitive functioning opens new preventive strategies. This work analyses the association between erythrocyte omega-3 index and omega-6 / omega-3 ratio and cognitive performance/ mild cognitive impairment. MATERIAL AND METHODS: We selected a random sample of individuals registered at a health centre aged ≥ 55 years...
March 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28534446/blood-fatty-acid-changes-in-healthy-young-americans-in-response-to-a-10-week-diet-that-increased-n-3-and-reduced-n-6-fatty-acid-consumption-a-randomised-controlled-trial
#7
Andrew J Young, Bernadette P Marriott, Catherine M Champagne, Michael R Hawes, Scott J Montain, Neil M Johannsen, Kevin Berry, Joseph R Hibbeln
Military personnel generally under-consume n-3 fatty acids and overconsume n-6 fatty acids. In a placebo-controlled, double-blinded study, we investigated whether a diet suitable for implementation in military dining facilities and civilian cafeterias could benefit n-3/n-6 fatty acid status of consumers. Three volunteer groups were provided different diets for 10 weeks. Control (CON) participants consumed meals from the US Military's Standard Garrison Dining Facility Menu. Experimental, moderate (EXP-Mod) and experimental-high (EXP-High) participants consumed the same meals, but high n-6 fatty acid and low n-3 fatty acid containing chicken, egg, oils and food ingredients were replaced with products having less n-6 fatty acids and more n-3 fatty acids...
May 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28527220/quantitative-erythrocyte-omega-3-epa-plus-dha-levels-are-related-to-higher-regional-cerebral-blood-flow-on-brain-spect
#8
Daniel G Amen, William S Harris, Parris M Kidd, Somayeh Meysami, Cyrus A Raji
BACKGROUND: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. OBJECTIVE: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acid levels. METHODS: A random sample of 166 study participants was drawn from a psychiatric referral clinical for which erythrocyte quantification of omega-3 eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (the Omega-3 Index) was available...
May 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28522317/the-association-among-cytochrome-p450-3a-progesterone-receptor-polymorphisms-plasma-17-alpha-hydroxyprogesterone-caproate-concentrations-and-spontaneous-preterm-birth
#9
Martha L Bustos, Steve N Caritis, Kathleen A Jablonski, Uma M Reddy, Yoram Sorokin, John M Thorp, Michael W Varner, Ronald J Wapner, Jay D Iams, Marshall W Carpenter, Alan M Peaceman, Brian M Mercer, Anthony Sciscione, Dwight J Rouse, Susan M Ramin
BACKGROUND: Infants born <37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children <5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-alpha hydroxyprogesterone caproate reduces preterm birth by 33% in women with history of spontaneous preterm birth. We demonstrated previously that plasma concentrations of 17-alpha hydroxyprogesterone caproate vary widely among pregnant women and that women with 17-alpha hydroxyprogesterone caproate plasma concentrations in the lowest quartile had spontaneous preterm birth rates of 40% vs rates of 25% in those women with higher concentrations...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28515269/effect-of-omega-3-supplementation-on-neuropathy-in-type-1-diabetes-a-12-month-pilot-trial
#10
Evan J H Lewis, Bruce A Perkins, Leif E Lovblom, Richard P Bazinet, Thomas M S Wolever, Vera Bril
OBJECTIVE: To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes mellitus (T1DM). METHODS: Individuals with T1DM and evidence of DSP as determined by a Toronto Clinical Neuropathy Score ≥1 were recruited to participate in a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (10 mL·d(-1); 750 mg eicosapentaenoic acid, 560 mg docosapentaenoic acid, and 1,020 mg docosahexaenoic acid) for 1 year...
May 17, 2017: Neurology
https://www.readbyqxmd.com/read/28515020/supplementation-with-high-dose-docosahexaenoic-acid-increases-the-omega-3-index-more-than-high-dose-eicosapentaenoic-acid
#11
Janie Allaire, William S Harris, Cécile Vors, Amélie Charest, Johanne Marin, Kristina Harris Jackson, André Tchernof, Patrick Couture, Benoît Lamarche
BACKGROUND: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (O3I), which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the O3I in men and women with abdominal obesity and subclinical inflammation...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28511049/the-omega-3-index-and-relative-risk-for-coronary-heart-disease-mortality-estimation-from-10-cohort-studies
#12
William S Harris, Liana Del Gobbo, Nathan L Tintle
BACKGROUND AND AIMS: A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and is a validated biomarker of omega-3 fatty acid tissue levels, but additional data are needed to confirm (or refute) the originally-proposed clinical cut-points of <4% (higher risk) and 8%-12% (lower risk)...
May 6, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28506114/the-fatty-liver-index-fli-relates-to-diabetes-specific-parameters-and-an-adverse-lipid-profile-in-a-cohort-of-nondiabetic-dyslipidemic-patients
#13
Michael Leutner, Christian Göbl, Oliver Schlager, Silvia Charwat-Resl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Katharina Maruszczak, Hacer Geyik, Helmut Prosch, Giovanni Pacini, Alexandra Kautzky-Willer
BACKGROUND: Patients with hyperlipidemia are at high risk for developing a fatty liver. The fatty liver index (FLI) is a noninvasive and well-established method for the estimation of a fatty liver. However, little is known about the metabolic characterization of nondiabetic treated patients with hyperlipidemia who have different risk levels for a fatty liver. METHODS: In this study, 74 nondiabetic patients with hyperlipidemia were divided into 3 groups according to their fatty liver index...
May 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28502503/the-effects-of-vitamin-d-and-omega-3-fatty-acid-co-supplementation-on-glycemic-control-and-lipid-concentrations-in-patients-with-gestational-diabetes
#14
Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Teibeh Hashemi, Mohsen Taghizadeh, Maryamalsadat Razavi, Marzieh Sanami, Zatollah Asemi
OBJECTIVE: This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on glucose metabolism and lipid concentrations in gestational diabetes (GDM) patients. METHODS: This randomized double-blind placebo-controlled clinical trial was done among 140 GDM patients. Participants were randomly divided into 4 groups to receive: (1) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid and 240 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 35); (2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 35); (3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 35), and (4) vitamin D placebo + omega-3 fatty acids placebo (n = 35) for 6 weeks...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28492102/determinants-of-fluid-intelligence-in-healthy-aging-omega-3-polyunsaturated-fatty-acid-status-and-frontoparietal-cortex-structure
#15
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Aron K Barbey
INTRODUCTION: Accumulating evidence indicates that cognitive decline depends not only upon changes in brain health, but critically, also upon nutritional status. Decline in fluid intelligence, one of the most debilitating aspects of cognitive aging, has been linked to omega-3 polyunsaturated fatty acid (PUFA) status; however, it is not known whether this phenomenon results from specific omega-3 PUFAs acting on particular aspects of brain health. Therefore, this study aims to explore whether particular patterns of omega-3 PUFAs influence fluid intelligence by supporting specific neural structures...
May 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28482294/association-between-fish-consumption-dietary-omega-3-fatty-acids-and-persistent-organic-pollutants-intake-and-type-2-diabetes-in-18-first-nations-in-ontario-canada
#16
Lesya Marushka, Malek Batal, William David, Harold Schwartz, Amy Ing, Karen Fediuk, Donald Sharp, Andrew Black, Constantine Tikhonov, Hing Man Chan
BACKGROUND: First Nations (FNs) populations in Canada experience a disproportionally higher rate of obesity and type 2 diabetes (T2D) compared to the general population. Recent data suggest that a high consumption of fish may help prevent T2D. On the other hand, fish might also be a potential source of environmental contaminants which could potentially be a risk factor for T2D. OBJECTIVE: To investigate the potential associations between self-reported T2D and consumption of locally-harvested fish, dietary long-chain omega-3 fatty acids (n-3FAs) and persistent organic pollutants intake among adult FNs living on reserve in Ontario...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28481961/healthy-lifestyle-during-early-pregnancy-and-risk-of-gestational-diabetes-mellitus
#17
Sylvia E Badon, Daniel A Enquobahrie, Paige D Wartko, Raymond S Miller, Chunfang Qiu, Bizu Gelaye, Tanya K Sorensen, Michelle A Williams
Previous studies have found associations between individual healthy behaviors and reduced risk of gestational diabetes mellitus (GDM); however, the association of composite healthy lifestyle during pregnancy with GDM has not been examined. Participants (n = 3,005) in the Omega study, a pregnancy cohort in Washington State (1996-2008), reported diet, physical activity, smoking, and stress during early pregnancy. Lifestyle components were dichotomized into healthy/unhealthy, then combined into a total lifestyle score (0-4)...
May 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28471913/increased-fat-absorption-from-enteral-formula-through-an-in-line-digestive-cartridge-in-patients-with-cystic-fibrosis
#18
Steven Freedman, David Orenstein, Philip Black, Perry Brown, Karen McCoy, John Stevens, Danica Grujic, Russell Clayton
OBJECTIVES: Supplemental enteral nutrition (EN) is used by approximately 12% of people with cystic fibrosis (CF). The objective of this study was to evaluate the safety, tolerability, and fat absorption of a new in-line digestive cartridge (Relizorb) that hydrolyzes fat in enteral formula provided to patients with CF. METHODS: Patients with CF receiving EN participated in a multicenter, randomized, double-blind, crossover trial with an open-label safety evaluation period...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28457318/predictors-of-change-in-omega-3-index-with-fish-oil-supplementation-in-peripheral-artery-disease
#19
Laura M Drudi, Melinda S Schaller, Jade Hiramoto, Warren Gasper, William S Harris, Nancy K Hills, S Marlene Grenon
BACKGROUND: The omega-3 index represents the red blood cell (RBC) content of two major long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid, and docosahexaenoic acid. We sought to determine factors associated with a favorable response to fish oil treatment and to characterize changes in RBC PUFAs associated with fish oil supplementation. METHODS: This study was a secondary analysis of the OMEGA-PAD I trial, a randomized, double-blinded, placebo-controlled trial investigating short-duration, high-dose n-3 PUFA oral supplementation on endothelial function and inflammation in subjects with peripheral arterial disease...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28442236/red-blood-cell-membrane-omega-3-fatty-acid-levels-and-physical-performance-cross-sectional-data-from-the-mapt-study
#20
Bertrand Fougère, Philipe de Souto Barreto, Sabine Goisser, Gaëlle Soriano, Sophie Guyonnet, Sandrine Andrieu, Bruno Vellas
BACKGROUND & AIMS: Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular and immune function, as well as physical performance and bone health in older adults. So far, few studies have highlighted the associations between PUFA status and performance-based tests of physical function. To study the associations between the omega-3 index (red blood cell (RBC) membrane content of omega-3 PUFAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and physical performance measured with the Short Physical Performance Battery (SPPB) in a sample of community-dwelling older adults...
April 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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