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https://www.readbyqxmd.com/read/28525320/sexual-and-reproductive-health-priorities-of-adolescent-girls-in-lagos-nigeria-findings-from-free-listing-interviews
#1
Juliet Iwelunmor, Sarah Blackstone, Ucheoma Nwaozuru, Donaldson Conserve, Patricia Iwelunmor, John E Ehiri
Background Adolescent girls in Nigeria experience a disproportionately high burden of sexual and reproductive health disparities that affect their well-being. Yet, little is known about adolescent girls' own unique perspectives of the sexual and reproductive health challenges they face, and possible solutions to these challenges. Aims To explore top sexual and reproductive health concerns of female adolescents in Nigeria and their perceptions regarding potential solutions to these issues. Methods Eighty adolescent girls attending two public secondary schools in Lagos, Nigeria completed individual free-listing interviews...
May 17, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28462827/prevalence-of-insulin-resistance-among-patients-attending-the-hiv-clinic-in-a-nigerian-tertiary-hospital
#2
Adeyemi O Dada, Temitope T Oshodi, Iwuchukwu O Ajie, Chinelo P Onyenekwu
BACKGROUND: Insulin Resistance(IR) is increasing in Africans as well as among the Human Immunodeficiency Virus(HIV) infected population for several reasons which include the viral infection itself and the use of Highly active antiretroviral therapy (HAART). This present study assessed the prevalence of IR among HIV infected population and the imminent effect of the disease and therapy on patients. METHODS: This cross sectional study was conducted in Lagos among 266 HIV infected participants and 130 HIV Negative controls aged 18-80 years...
April 12, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28453241/stigma-access-to-healthcare-and-hiv-risks-among-men-who-sell-sex-to-men-in-nigeria
#3
Trevor A Crowell, Babajide Keshinro, Stefan D Baral, Sheree R Schwartz, Shauna Stahlman, Rebecca G Nowak, Sylvia Adebajo, William A Blattner, Manhattan E Charurat, Julie A Ake
INTRODUCTION: Among men who have sex with men (MSM), men who sell sex (MSS) may be subject to increased sexual behaviour-related stigma that affects uptake of healthcare and risk of sexually transmitted infections (STIs). The objectives of this study were to characterize stigma, access to care, and prevalence of HIV among MSS in Nigeria. METHODS: Respondent-driven sampling was used to recruit MSM in Abuja and Lagos into the ongoing TRUST/RV368 study, which provides HIV testing and treatment...
April 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28355252/factors-associated-with-early-mycological-clearance-in-hiv-associated-cryptococcal-meningitis
#4
Fátima Concha-Velasco, Elsa González-Lagos, Carlos Seas, Beatriz Bustamante
INTRODUCTION: The first-line combination therapy for HIV-associated cryptococcal meningitis (CM), a condition of high mortality particularly in the first two weeks of treatment, consists of amphotericin B plus flucytosine (5-FC). Given that 5-FC remains unavailable in many countries, the knowledge of factors influencing mycological clearance in patients treated with second-line therapy could contribute to effective management. OBJECTIVES: To determine the factors associated with the clearance of Cryptococcus sp...
2017: PloS One
https://www.readbyqxmd.com/read/28338097/the-cellular-protein-hnrnp-a2-b1-enhances-hiv-1-transcription-by-unfolding-ltr-promoter-g-quadruplexes
#5
Matteo Scalabrin, Ilaria Frasson, Emanuela Ruggiero, Rosalba Perrone, Elena Tosoni, Sara Lago, Martina Tassinari, Giorgio Palù, Sara N Richter
G-quadruplexes are four-stranded conformations of nucleic acids that act as cellular epigenetic regulators. A dynamic G-quadruplex forming region in the HIV-1 LTR promoter represses HIV-1 transcription when in the folded conformation. This activity is enhanced by nucleolin, which induces and stabilizes the HIV-1 LTR G-quadruplexes. In this work by a combined pull-down/mass spectrometry approach, we consistently found hnRNP A2/B1 as an additional LTR-G-quadruplex interacting protein. Surface plasmon resonance confirmed G-quadruplex specificity over linear sequences and fluorescence resonance energy transfer analysis indicated that hnRNP A2/B1 is able to efficiently unfold the LTR G-quadruplexes...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337490/effect-of-trimethoprim-sulfamethoxazole-prophylaxis-on-feacal-carriage-rates-of-resistant-isolates-of-escherichia-coli-in-hiv-infected-adult-patients-in-lagos
#6
C C Egwuatu, F T Ogunsola, A A Iwuafor, C N Akujobi, T O Egwuatu, A U Nnachi, O O Oduyebo
BACKGROUND: The daily use of Trimethoprim-Sulfamethoxazole (TMP-SMX) prophylaxis reduces morbidity and mortality among patients infected with human immunodeficiency virus (HIV) but its impact on increasing antimicrobial resistance rates has been of public health concern, globally. This study investigated the effect of daily TMP-SMX prophylaxis on feacal carriage rates of resistant isolates of Escherichia coli in HIV-infected adult patients in Lagos. METHODS: A total of 550 HIV-infected patients with CD4-cell counts of less than 350 cells/mm(3) who were eligible for TMP-SMX prophylaxis and attending Lagos University Teaching Hospital, Lagos, Nigeria, were recruited for this study...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28235839/sexual-partner-characteristics-and-incident-rectal-neisseria-gonorrhoeae-and-chlamydia-trachomatis-infections-among-gay-men-and-other-men-who-have-sex-with-men-msm-a-prospective-cohort-in-abuja-and-lagos-nigeria
#7
Habib O Ramadhani, Hongjie Liu, Rebecca G Nowak, Trevor A Crowell, Teclaire Ndomb, Charlotte Gaydos, Sheila Peel, Nicaise Ndembi, Stefan D Baral, Julie Ake, Man E Charurat
BACKGROUND: STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. METHODS: TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks...
February 24, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28202799/clonal-complexity-in-mycobacterium-tuberculosis-can-hamper-diagnostic-procedures
#8
Laura Pérez-Lago, Marta Herranz, Yurena Navarro, María Jesús Ruiz Serrano, Pilar Miralles, Emilio Bouza, Darío García-de-Viedma
Clonal complexity is increasingly accepted in Mycobacterium tuberculosis infection, including mixed infections by ≥2 strains, which usually occur in settings with a high burden of tuberculosis and/or a high risk of overexposure to infected patients. Mixed infections can hamper diagnostic procedures; obtaining an accurate antibiogram is difficult when the susceptibility patterns of the strains differ. Here, we show how mixed infections can also prove challenging for other diagnostic procedures, even outside settings where mixed infections are traditionally expected...
May 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28060860/prevalence-and-incidence-of-hcv-infection-among-prisoners-in-central-brazil
#9
Marco Antonio Moreira Puga, Larissa Melo Bandeira, Mauricio Antonio Pompilio, Julio Croda, Grazielli Rocha de Rezende, Luiz Fernando Paiva Dorisbor, Tayana Serpa Ortiz Tanaka, Gabriela Alves Cesar, Sheila Araújo Teles, Simone Simionatto, Alisson Richard Teixeira Novais, Bruna Nepomuceno, Lisie Souza Castro, Barbara Vieira do Lago, Ana Rita Coimbra Motta-Castro
The aim of this multicenter, cross sectional study was to assess the prevalence, incidence and associated risk factors among incarcerated populations from twelve Brazilian prisons. The total of 3,368 individuals from twelve prisons was randomly recruited between March 2013 and March 2014. Participants were interviewed, and provided blood samples which were tested for antibodies to Hepatitis C (HCV ab). One year after the first investigation, a cohort study was conducted with 1,656 inmates who participated the cross sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/27931519/high-prevalence-of-hiv-chlamydia-and-gonorrhoea-among-men-who-have-sex-with-men-and-transgender-women-attending-trusted-community-centres-in-abuja-and-lagos-nigeria
#10
Babajide Keshinro, Trevor A Crowell, Rebecca G Nowak, Sylvia Adebajo, Sheila Peel, Charlotte A Gaydos, Cristina Rodriguez-Hart, Stefan D Baral, Melissa J Walsh, Ogbonnaya S Njoku, Sunday Odeyemi, Teclaire Ngo-Ndomb, William A Blattner, Merlin L Robb, Manhattan E Charurat, Julie Ake
INTRODUCTION: Sexually transmitted infection (STI) and HIV prevalence have been reported to be higher amongst men who have sex with men (MSM) in Nigeria than in the general population. The objective of this study was to characterize the prevalence of HIV, chlamydia and gonorrhoea in this population using laboratory-based universal testing. METHODS: TRUST/RV368 represents a cohort of MSM and transgender women (TGW) recruited at trusted community centres in Abuja and Lagos, Nigeria, using respondent-driven sampling (RDS)...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27847006/determinants-of-health-system-delay-at-public-and-private-directly-observed-treatment-short-course-facilities-in-lagos-state-nigeria-a-cross-sectional-study
#11
Olusola Adedeji Adejumo, Olusoji James Daniel, Andrew Folarin Otesanya, Esther Ngozi Adejumo
OBJECTIVE/BACKGROUND: Despite several studies on health system delay (HSD) among tuberculosis (TB) patients in Nigeria, no study has compared HSD in private and public health facilities. This study assessed the determinants of HSD in public and private health facilities offering the directly observed treatment, short course (DOTS). METHODS: A descriptive cross-sectional study was conducted. A total of 470 new smear-positive TB patients aged 14years and older were consecutively recruited between October 1, 2012, and December 31, 2012, from 34 (23 public and 11 private) DOTS facilities that offered treatment and microscopy services...
September 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#12
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27812146/differences-in-the-access-to-sterilization-between-women-living-and-not-living-with-hiv-results-from-the-genih-study-brazil
#13
Regina Maria Barbosa, Cristiane da Silva Cabral, Tania di Giacomo do Lago, Adriana de Araujo Pinho
BACKGROUND: In many countries, young women of reproductive age have been especially affected by the HIV epidemic, which have fostered research to better understand how HIV infection influences and shapes women´s fertility and reproductive and sexual decisions. In Brazil, few studies have focused on the impact of the HIV epidemic on contraceptive choices among women living with HIV (WLHIV). OBJECTIVE: This study evaluates the impact HIV infection may have in the access to female sterilization in Brazil, using a time-to-event analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27578403/role-of-healthcare-in-childbearing-decision-making-of-wlha-in-nigeria-application-of-pen-3-cultural-model
#14
Y A Sofolahan-Oladeinde, J I Iwelunmor, D F Conserve, A Gbadegesin, C O Airhihenbuwa
Healthcare experiences among women living with HIV/AIDS (WLHA), determine their utilisation of sexual and reproductive health services, which ultimately influences their decisions on childbearing. This study aimed to understand the importance of healthcare support in the childbearing decision-making processes of WLHA, and its impact on eliminating new paediatric HIV infections. We conducted in-depth interviews between July and August 2012 with 15 WLHA receiving clinical HIV care at a teaching hospital in Lagos...
August 31, 2016: Global Public Health
https://www.readbyqxmd.com/read/27578293/cd4-decay-rate-as-an-indicator-of-the-time-interval-between-initial-infection-and-first-diagnosis-among-drug-na%C3%A3-ve-human-immunodeficiency-virus-seropositive-individuals-in-lagos-nigeria
#15
Babatunde Olanrewaju Motayo, Samson O Aturaka, Babatunde A Olusola, I Joseph Ogiogwa, Nataniel N Shidali, Olusola Akingbade, Adedayo O Faneye
OBJECTIVE: The aim of this study was to determine the time interval between human immunodeficiency virus (HIV) infection and the first diagnosis among drug-naïve individuals in Badagry, Nigeria. SUBJECTS AND METHODS: A sample of 213 subjects who tested HIV positive for the first time were enrolled in this study. The HIV diagnosis was performed using Startpak® and Determine® kits, and a CD4 count was carried out using a FACS Count® flow cytometer. The mean CD4 values were determined by gender and age groups...
2016: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/27512845/significant-contribution-of-subtype-g-to-hiv-1-genetic-complexity-in-nigeria-identified-by-a-newly-developed-subtyping-assay-specific-for-subtype-g-and-crf02_ag
#16
Richard A Heipertz, Ojor Ayemoba, Eric Sanders-Buell, Kultida Poltavee, Phuc Pham, Gustavo H Kijak, Esther Lei, Meera Bose, Shana Howell, Anne Marie OʼSullivan, Adam Bates, Taylor Cervenka, Janelle Kuroiwa, Akindiran Akintunde, Onyekachukwu Ibezim, Abraham Alabi, Obumneke Okoye, Mark Manak, Jennifer Malia, Sheila Peel, Mohammed Maisaka, Darrell Singer, Robert J O'Connell, Merlin L Robb, Jerome H Kim, Nelson L Michael, Ogbonnaya Njoku, Sodsai Tovanabutra
While abundant sequence information is available from human immunodeficiency virus type 1 (HIV-1) subtypes A, B, C and CRF01_AE for HIV-1 vaccine design, sequences from West Africa are less represented. We sought to augment our understanding of HIV-1 variants circulating in 6 Nigerian cities as a step to subsequent HIV-1 vaccine development.The G/CRF02_AG multi-region hybridization assay (MHA) was developed to differentiate subtype G, CRF02_AG and their recombinants from other subtypes based on 7 HIV-1 segments...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27423745/trends-and-risk-factors-for-obesity-among-hiv-positive-nigerians-on-antiretroviral-therapy
#17
L O Ezechi, Z A Musa, V O Otobo, I E Idigbe, O C Ezechi
INTRODUCTION: The increased access to antiretroviral therapy has changed the once deadly infection to a chronic medical condition, resulting in a dramatic change in causes of morbidity and mortality among HIV infected individuals. Obesity and its cardiovascular sequelae are increasingly reported in the literature. However, data on the burden, trends and risk factors for obesity are sparse in countries worst hit by the epidemic. OBJECTIVES: To investigate the trend and risk factors for obesity among a cohort of HIV infected adults on antiretroviral therapy...
June 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/27347295/risk-factors-and-assessment-for-cardiovascular-disease-among-hiv-positive-patients-attending-a-nigerian-tertiary-hospital
#18
Ifeyinwa Dorothy Osegbe, Oyetunji Olukayode Soriyan, Abiola Ann Ogbenna, Henry Chima Okpara, Elaine Chinyere Azinge
INTRODUCTION: Cardiovascular risk factors are prevalent in HIV-positive patients which places them at increased risk for cardiovascular disease (CVD). We aimed to determine the risk factors and risk assessment for CVD in HIV-positive patients with and without antiretroviral therapy. METHODS: This was a cross-sectional study of HIV-positive patients attending the Lagos University Teaching Hospital, Nigeria. Anthropometric and blood pressure measurements were performed; fasting lipid profile, plasma glucose, homocysteine and hsCRP were determined, as well as prevalences and risk assessments...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27295832/prevalence-of-wasting-stunting-and-underweight-among-hiv-infected-underfives-in-lagos-using-w-h-o-z-score
#19
Patricia E Akintan, Adebola Akinsulie, Edamisan Temiye, Christopher Esezobor
BACKGROUND: HIV affects more than 2.3 million children worldwide and 90% live in Africa. Malnutrition is also a major problem in Africa with 25% of children under the age of five being malnourished. OBJECTIVE: The study is to determine the nutritional status of HIV infected children using weight-for-age, height-for-age and weight-for-height. METHODS: This was a cross sectional descriptive study where the severity of malnutrition based on weight for age, height for age and weight for weight for height of HIV infected children were compared with controls...
April 2015: Nigerian Quarterly Journal of Hospital Medicine
https://www.readbyqxmd.com/read/27295815/selenium-status-and-infant-birth-weight-among-hiv-positive-and-hiv-negative-pregnant-women-in-lagos-nigeria
#20
Christian Chigozie Makwe, Francis Izuegbunam Nwabua, Rose Ihuoma Anorlu
BACKGROUND: During pregnancy, selenium deficiency and reduced antioxidant activities may result in adverse perinatal outcome such as low birthweight, which is associated with significant perinatal morbidity and mortality. Many studies have reported conflicting findings on the relationship between maternal selenium status and infant birth weight. OBJECTIVE: This study is to determine the relationship between maternal serum selenium concentration and infant birthweight in HIV-positive and HIV-negative pregnant women at term...
July 2015: Nigerian Quarterly Journal of Hospital Medicine
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