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https://www.readbyqxmd.com/read/29788937/seroprevalence-of-transfusion-transmissible-infections-hbv-hcv-syphilis-and-hiv-among-prospective-blood-donors-in-a-tertiary-health-care-facility-in-calabar-nigeria-an-eleven-years-evaluation
#1
Henshaw Uchechi Okoroiwu, Ifeyinwa Maryann Okafor, Enosakhare Aiyudubie Asemota, Dorathy Chioma Okpokam
BACKGROUND: Provision of constant and safe blood has been a public health challenge in Sub-Saharan Africa with high prevalence of transfusion-transmissible infections (TTIs). This study was aimed at determining the trend and seroprevalence of HBV, HCV, syphilis and HIV across the years within study among prospective blood donors at blood bank in University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria. METHODS: A retrospective analysis of blood donor data from January 2005 to December 2016 was conducted in Blood Bank/Donor Clinic of University of Calabar Teaching Hospital, Calabar, Nigeria...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29781881/individual-and-network-factors-associated-with-hiv-care-continuum-outcomes-among-nigerian-msm-accessing-healthcare-services
#2
Habib O Ramadhani, Nicaise Ndembi, Rebecca G Nowak, Uchenna Ononaku, Jerry Gwamna, Ifeanyi Orazulike, Sylvia Adebajo, Trevor A Crowell, Hongjie Liu, Stefan D Baral, Julie Ake, Man E Charurat
BACKGROUND: and setting: As data on the determinants of the HIV care continuum from key populations such as men who have sex with men (MSM) in resource-limited, settings (RLS) are limited, the study aimed to characterize HIV care continuum outcomes and assess individual and network barriers to progression through the HIV care continuum among MSM in Abuja and Lagos, Nigeria. METHODS: TRUST/RV368 study used respondent-driven-sampling to accrue MSM into community-based clinics in Nigeria...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781693/collaborative-postgraduate-training-in-family-medicine-and-primary-care-reflections-on-my-visit-to-south-africa
#3
Felicity Goodyear-Smith
This reflection describes my funded visit to South Africa to assist in primary care research capacity building as Chair, WONCA Working Party on Research (WP-R). The trip included time at the Universities of Walter Sisulu, Limpopo and Stellenbosch to mentor postgraduate students working on master's and PhD theses. I held one-on-one and group sessions and ran interactive scientific writing workshops. I assisted with the establishment of a Stellenbosch University Family Physician Research Network of faculty academics and family physicians (FP) which will generate research questions from community stakeholders...
April 26, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29742119/prior-subclinical-histoplasmosis-revealed-in-nigeria-using-histoplasmin-skin-testing
#4
Rita O Oladele, Conchita Toriello, Folasade T Ogunsola, Olusola O Ayanlowo, Philip Foden, Adetona S Fayemiwo, Iriagbonse I Osaigbovo, Anthony A Iwuafor, Shuwaram Shettima, Halimat A Ekundayo, Malcolm D Richardson, David W Denning
OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ≥ 350 cells/mm3 regardless of their ART status from March to May 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29740232/hiv-epidemiology-in-nigeria
#5
REVIEW
Awoyemi Abayomi Awofala, Olusegun Emmanuel Ogundele
Nigeria realizes the devastating effects of HIV/AIDS on its people, health, economic, and social progress fairly recently. This paper analyses descriptively the HIV epidemiology in Nigeria based on the sentinel surveillance system in place. Recently, it is estimated that about 3, 229, 757 people live with HIV in Nigeria and about 220, 393 new HIV infections occurred in 2013 and 210,031 died from AIDS related cases. People practicing low-risk sex are the driving force of HIV epidemic in Nigeria while the high risk groups involving female sex workers, men who have sex with men and injecting drug users contribute substantially to new infections...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29719927/comparative-study-of-mefloquine-and-sulphadoxine-pyrimethamine-for-malaria-prevention-among-pregnant-women-with-hiv-in-southwest-nigeria
#6
Oriyomi Akinyotu, Folasade Bello, Rukiyat Abdus-Salam, Ayodele Arowojolu
OBJECTIVE: To compare the effectiveness of mefloquine and sulphadoxine-pyrimethamine as intermittent preventive therapy for malaria among pregnant women with HIV. METHODS: The present randomized, controlled, prospective, open-label study enrolled women with HIV who had reached at least 16 weeks of pregnancy attending prenatal clinics at secondary and tertiary health facilities in South West Nigeria between January 1 and August 31, 2016. Block randomization was used to assign patients to treatment with mefloquine or sulphadoxine-pyrimethamine for malaria prophylaxis...
May 2, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29718906/explaining-the-heterogeneity-in-average-costs-per-hiv-aids-patient-in-nigeria-the-role-of-supply-side-and-service-delivery-characteristics
#7
Sergio Bautista-Arredondo, M Arantxa Colchero, Ogbonna O Amanze, Gina La Hera-Fuentes, Omar Silverman-Retana, David Contreras-Loya, Gregory A Ashefor, Kayode M Ogungbemi
OBJECTIVE: We estimated the average annual cost per patient of ART per facility (unit cost) in Nigeria, described the variation in costs across facilities, and identified factors associated with this variation. METHODS: We used facility-level data of 80 facilities in Nigeria, collected between December 2014 and May 2015. We estimated unit costs at each facility as the ratio of total costs (the sum of costs of staff, recurrent inputs and services, capital, training, laboratory tests, and antiretroviral and TB treatment drugs) divided by the annual number of patients...
2018: PloS One
https://www.readbyqxmd.com/read/29713470/hiv-related-knowledge-in-nigeria-a-2003-2013-trend-analysis
#8
Lena Faust, Michael Ekholuenetale, Sanni Yaya
Background: Given Nigeria's status as the country with the second highest number of people living with HIV globally, and 9% of the total global burden of HIV being attributable to Nigeria alone in 2013, improving our understanding of the nature of the HIV epidemic in Nigeria is crucial. As HIV-related knowledge may be an important contributor to engagement in preventive behaviours, it is of interest to investigate trends in HIV-related knowledge in Nigeria with the purpose of informing future HIV prevention and education efforts...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29682399/retention-in-differentiated-care-multiple-measures-analysis-for-a-decentralized-hiv-care-and-treatment-program-in-north-central-nigeria
#9
Patricia A Agaba, Becky L Genberg, Atiene S Sagay, Oche O Agbaji, Seema T Meloni, Nancin Y Dadem, Grace O Kolawole, Prosper Okonkwo, Phyllis J Kanki, Norma C Ware
Objective: Differentiated care refers collectively to flexible service models designed to meet the differing needs of HIV-infected persons in resource-scarce settings. Decentralization is one such service model. Retention is a key indicator for monitoring the success of HIV treatment and care programs. We used multiple measures to compare retention in a cohort of patients receiving HIV care at "hub" (central) and "spoke" (decentralized) sites in a large public HIV treatment program in north central Nigeria...
2018: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#10
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29676342/audit-of-prevention-of-mother-to-child-transmission-programme-interventions-in-hiv-exposed-children-at-national-hospital-abuja-nigeria
#11
Mariya Mukhtar-Yola, Adekunle Tolulope Otuneye, Amsa Baba Mairami, Yewande Wey, Vincent Nwatah, Lamidi Isah Audu
Background: Ninety percentage of children acquire human immunodeficiency virus (HIV) infection in the form of Mother-to-child Transmission (MTCT). In the absence of interventions, transmission rates range from 15% to 45%. This can be reduced to below 5% with effective interventions. The last published national guideline (NG) on prevention of MTCT (PMTCT) was in 2010. Clinical audits are essential in improving the quality of care delivered to patients. Objectives: The study objectives were to determine the rate of MTCT of HIV in exposed infants at a follow-up clinic between 2011 and 2014 and to determine the level of adherence to 2010 NG on the use of highly active antiretroviral therapy (HAART), polymerase chain reaction (PCR) testing, feeding options, antiretroviral (ARV) prophylaxis and the use of co-trimoxazole (CTZ)...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#12
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29675995/bridging-the-hiv-treatment-gap-in-nigeria-examining-community-antiretroviral-treatment-models
#13
Edward A Oladele, Okikiolu A Badejo, Christopher Obanubi, Emeka F Okechukwu, Ezekiel James, Golden Owhonda, Onuche I Omeh, Moyosola Abass, Olubunmi R Negedu-Momoh, Norma Ojehomon, Dorothy Oqua, Satish Raj-Pandey, Hadiza Khamofu, Kwasi Torpey
INTRODUCTION: Significant gaps persist in providing HIV treatment to all who are in need. Restricting care delivery to healthcare facilities will continue to perpetuate this gap in limited resource settings. We assessed a large-scale community-based programme for effectiveness in identifying people living with HIV and linking them to antiretroviral treatment. METHODS: A retrospective secular trend study of 14 high burden local government areas of Nigeria was conducted in which two models of community antiretroviral treatment delivery were implemented: Model A (on-site initiation) and Model B (immediate referral) clusters...
April 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29673137/herb-induced-liver-injuries-in-developing-nations-an-update
#14
REVIEW
Cecilia Nwadiuto Amadi, Orish Ebere Orisakwe
The last few decades have seen a rise in the use of herbal supplements, natural products, and traditional medicines. However, there are growing concerns related to the safety and toxicities of these medicines. These herbal medicines are associated with complications such as liver damage with a high incidence of mortalities and morbidities. Clinical manifestations range from asymptomatic cases with abnormal liver functions tests to sudden and severe liver failure necessitating liver transplantation. This work aimed to review the etiology, risk factors, diagnosis, clinical manifestations and selected clinical case reports of herbal hepatotoxicity in developing nations...
April 17, 2018: Toxics
https://www.readbyqxmd.com/read/29668591/prevalence-and-correlates-of-chronic-kidney-disease-ckd-among-art-naive-hiv-patients-in-the-niger-delta-region-of-nigeria
#15
Udeme E Ekrikpo, Andre P Kengne, Effiong E Akpan, Emmanuel E Effa, Aminu K Bello, John U Ekott, Cindy George, Babatunde L Salako, Ikechi G Okpechi
Widespread use of antiretroviral therapy (ART) in human immunodeficiency virus (HIV) patients has led to improved longevity with the attendant increase in noncommunicable disease prevalence including chronic kidney disease (CKD). This study documents the prevalence of CKD in a large HIV population in Southern Nigeria.This is a single center, 15-year analysis in ART-naïve patients. CKD was defined as the occurrence of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m on 2 consecutive occasions 3 to 12 months apart using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665809/generating-evidence-for-health-policy-in-challenging-settings-lessons-learned-from-four-prevention-of-mother-to-child-transmission-of-hiv-implementation-research-studies-in-nigeria
#16
Nadia A Sam-Agudu, Muktar H Aliyu, Olusegun A Adeyemi, Frank Oronsaye, Bolanle Oyeledun, Amaka G Ogidi, Echezona E Ezeanolue
BACKGROUND: Implementation research (IR) facilitates health systems strengthening and optimal patient outcomes by generating evidence for scale-up of efficacious strategies in context. Thus, difficulties in generating IR evidence, particularly in limited-resource settings with wide disease prevention and treatment gaps, need to be anticipated and addressed. Nigeria is a priority country for the prevention of mother-to-child transmission of HIV (PMTCT). This paper analyses the experiences of four PMTCT IR studies in Nigeria, and proffers solutions to major challenges encountered during implementation...
April 17, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29660833/selenium-deficiency-and-pregnancy-outcome-in-pregnant-women-with-hiv-in-lagos-nigeria
#17
Kehinde S Okunade, Olusola F Olowoselu, Gbemisola E Osanyin, Sarah John-Olabode, Sulaimon A Akanmu, Rose I Anorlu
OBJECTIVE: To investigate the prevalence of maternal selenium deficiency and its effects on pregnancy outcomes in pregnant women with HIV in Lagos, Nigeria. METHODS: The present descriptive cross-sectional study enrolled women aged 15-49 years with HIV who were at 14-26 weeks of a singleton pregnancy and were attending Lagos University Teaching Hospital, Lagos, Nigeria, between August 1, 2016, and April 30, 2017. Participants were selected by consecutive sampling and baseline data were collected through interviews...
April 16, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29629291/zinc-copper-cd4-t-cell-count-and-some-hematological-parameters-of-hiv-infected-subjects-in-southern-nigeria
#18
Enosakhare A Asemota, Ifeyinwa M Okafor, Henshaw U Okoroiwu, Ewaro R Ekong, Stanley Obialor Anyanwu, Esienanwan Esien Efiong, Francis Udomah
Background: Low concentration of trace elements has been associated with poor prognosis and mortality in HIV infection. Methods: A cross sectional study was conducted among 100 HIV-infected subjects (70 were on ART treatment, while 30 were ART naïve). Fifty (50) apparently healthy controls were enrolled. Concentration of serum levels of zinc and copper was done using atomic absorption spectrometric method, while complete blood count was determined using automated blood analyzer...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29624937/trends-and-determinants-of-comprehensive-knowledge-of-hiv-among-adolescents-and-young-adults-in-nigeria-2003-2013
#19
Ayodeji B Oginni, Sylvia B Adebajo, Babatunde A Ahonsi
This study examined comprehensive knowledge of HIV (CKH) and its determinants among young people aged 15-24 years in Nigeria between 2003 and 2013. Secondary analysis was conducted on three rounds of NDHS 2003, 2008 and 2013 data. CKH increased significantly between 2003 and 2013, but the level reached in 2013 fell short of the global expectation for young people. Its significant determinants included gender, age, educational attainment, place and region of residence, household wealth status and uptake of HIV test...
June 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29616458/notifiable-infectious-diseases-in-refugees-and-asylum-seekers-experience-from-a-major-reception-center-in-munich-germany
#20
Martin Alberer, Svea Malinowski, Linda Sanftenberg, Jörg Schelling
PURPOSE: In 2016, the number of refugees worldwide reached 65.6 million. So far, only limited data are available on the health status of refugees and asylum seekers (RAs). Especially, notifiable infectious diseases (NIDs) carry the risk of outbreaks in communal accommodations hosting RAs. METHODS: We conducted a monocentric retrolective cross-sectional study including 15,137 RAs treated in a special health care unit for RAs located in the major reception center in Munich from November 2014 to October 2016...
April 3, 2018: Infection
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