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https://www.readbyqxmd.com/read/29139188/biomimic-peptide-gated-nanoporous-membrane-for-on-demand-molecule-transport
#1
Kai Xiao, Kai Wu, Lu Chen, Xiang-Yu Kong, Yuqi Zhang, Liping Wen, Lei Jiang
The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membrane, with nanoscopic pores, high porosity, uniform pore dimension, and controllable surface chemical properties, hold tremendous potential to achieve this function. Here, we report a nano-gating system for on-demand molecule transport based on peptide-gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on-off-states transport profiles via reversible conformational switch of peptides...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29137562/beware-the-educational-fix-limitations-of-efforts-to-promote-mental-health-literacy
#2
Patrick Corrigan
Public health professionals seek to promote health literacy through education. In the mental health arena, such approaches have included teaching primary care gatekeepers to screen for early identification of suicide risk and teaching members of the general public to engage peers in need of mental health treatment and guide them into evidence-based care. Educational positivism is the belief that this pedagogic enterprise is unlimited, leading to a "more is better" approach. Despite its promise, however, educational approaches may have muted effects...
November 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29137559/factors-influencing-receipt-of-mental-health-services-among-medicaid-beneficiaries-with-breast-cancer
#3
Michael T Halpern, Mallorie H Fiero
OBJECTIVE: This study examined associations of state-level Medicaid reimbursement and other policies and patient characteristics with receipt of mental health diagnostic and treatment services for beneficiaries with cancer. METHODS: Data (2006-2008) from Medicaid beneficiaries with breast cancer were analyzed to examine predictors of receiving mental health diagnostic services and mental health treatment services. Independent variables included state-level Medicaid policies for reimbursements for mental health services and consultations (requests from one health care provider to another for advice regarding evaluation or management of a specific problem), required patient copayments, and requirements governing the timing of Medicaid eligibility recertification (eligibility recertification period)...
November 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29130940/neuropeptide-y-regulates-a-vascular-gateway-for-hematopoietic-stem-and-progenitor-cells
#4
Pratibha Singh, Jonathan Hoggatt, Malgorzata M Kamocka, Khalid S Mohammad, Mary R Saunders, Hongge Li, Jennifer Speth, Nadia Carlesso, Theresa A Guise, Louis M Pelus
Endothelial cells (ECs) are components of the hematopoietic microenvironment and regulate hematopoietic stem and progenitor cell (HSPC) homeostasis. Cytokine treatments that cause HSPC trafficking to peripheral blood are associated with an increase in dipeptidylpeptidase 4/CD26 (DPP4/CD26), an enzyme that truncates the neurotransmitter neuropeptide Y (NPY). Here, we show that enzymatically altered NPY signaling in ECs caused reduced VE-cadherin and CD31 expression along EC junctions, resulting in increased vascular permeability and HSPC egress...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29124936/in-vivo-ct-photoacoustic-imaging-and-nir-triggered-chemo-photothermal-combined-therapy-based-on-a-gold-nanostar-mesoporous-silica-and-thermo-sensitive-liposomes-composited-nanoprobe
#5
Jie An, Xiao-Quan Yang, Kai Cheng, Xian-Lin Song, Lin Zhang, Cheng Li, Xiao-Shuai Zhang, Yang Xuan, Yuan-Yang Song, Bi-Yun Fang, Xiao-Lin Hou, Yuan-Di Zhao, Bo Liu
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/CT imaging of tumor were achieved by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA), it was composed of gold nanostar core and doxorubicin (DOX) loading mesoporous silica shell (GMS), which was coated with folic acid (FA) modified thermosensitively supported lipid bilayer (FA-SLB) as gatekeeper...
November 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29123596/a-scoping-review-of-community-pharmacists-and-patients-at-risk-of-suicide
#6
REVIEW
Andrea Lynn Murphy, Katelyn Hillier, Randa Ataya, Pierre Thabet, Anne Marie Whelan, Claire O'Reilly, David Gardner
Background: Medications are commonly used in suicide attempts. Pharmacists are inextricably linked to medications and may have roles in helping those at risk of suicide. We conducted a scoping review to characterize the existing literature and make recommendations about future research. Methods: We used a 6-step approach based on an existing scoping review methodological framework, including identifying the research question; identifying relevant studies and other literature; study and literature selection; data charting; collating, summarizing and reporting results; and dissemination of results...
November 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29118738/monitoring-of-dual-crispr-cas9-mediated-steroidogenic-acute-regulatory-protein-gene-deletion-and-cholesterol-accumulation-using-high-resolution-fluorescence-in-situ-hybridization-in-a-single-cell
#7
Jinwoo Lee, Colin Jefcoate
Recent advances in fluorescence microscopy, coupled with CRISPR/Cas9 gene editing technology, provide opportunities for understanding gene regulation at the single-cell level. The application of direct imaging shown here provides an in situ side-by-side comparison of CRISPR/Cas9-edited cells and adjacent unedited cells. We apply this methodology to the steroidogenic acute regulatory protein (StAR) gene in Y-1 adrenal cells and MA-10 testis cells. StAR is a gatekeeper protein that controls the access of cholesterol from the cytoplasm to the inner mitochondria...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29116748/mno2-functionalized-co-p-nanocomposite-a-new-theranostic-agent-for-ph-triggered-t1-t2-dual-modality-magnetic-resonance-imaging-guided-chemo-photothermal-synergistic-therapy
#8
Longhai Jin, Jianhua Liu, Ying Tang, Lanqing Cao, Tianqi Zhang, Qinghai Yuan, Yinghui Wang, Hongjie Zhang
Construction of stimuli-responsive theranostic nanoagents that can improve the sensitivity of diagnostic imaging and boost the therapeutic efficiency has been demostrated to a promising approach for cancer diagnosis and treatment. Herein, we constructed a novel theranostic agent with Co-P nanocomposites as core, mesoporous silica as shell, and MnO2 nanosheets as "gatekeeper", which have been employed for pH-activatable T1/T2 dual mode MRI-guided chemo-photothermal combination anticancer therapy in vitro and in vivo...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29115753/a-novice-researcher-s-reflection-on-recruiting-participants-for-qualitative-research
#9
Anne Marks, Lesley Wilkes, Stacy Blythe, Rhonda Griffiths
BACKGROUND: This paper is a reflection by a PhD candidate on her qualitative study involving parents, diabetes educators and school teachers who were caring for a child with type 1 diabetes using intensive insulin therapy in primary school. AIM: To reflect on a novice researcher's experience of recruiting research participants from community, health and education settings in Australia. DISCUSSION: Participants were successfully recruited for the study using internet communication tools: Facebook support groups; the Australian Diabetes Educators Association (ADEA) e-newsletter; and emails sent to school principals...
September 19, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/29112975/referral-determinants-in-swiss-primary-care-with-a-special-focus-on-managed-care
#10
Ryan Tandjung, Seraina Morell, Andreas Hanhart, Andreas Haefeli, Fabio Valeri, Thomas Rosemann, Oliver Senn
Studies have shown large variation of referral probabilities in different countries, and many influencing factors have been described. This variation is most likely explained by different healthcare systems, particularly to which extent primary care physicians (PCPs) act as gatekeepers. In Switzerland no mandatory gatekeeping system exists, however insurance companies offer voluntary managed care plans with reduced insurance premiums. We aimed at investigating the role of managed care plans as a potential referral determinant in a non-gatekeeping healthcare system...
2017: PloS One
https://www.readbyqxmd.com/read/29112861/long-fiber-carbon-nanotubes-replicate-asbestos-induced-mesothelioma-with-disruption-of-the-tumor-suppressor-gene-cdkn2a-ink4a-arf
#11
Tatyana Chernova, Fiona A Murphy, Sara Galavotti, Xiao-Ming Sun, Ian R Powley, Stefano Grosso, Anja Schinwald, Joaquin Zacarias-Cabeza, Kate M Dudek, David Dinsdale, John Le Quesne, Jonathan Bennett, Apostolos Nakas, Peter Greaves, Craig A Poland, Ken Donaldson, Martin Bushell, Anne E Willis, Marion MacFarlane
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown. Moreover, late diagnosis means that mesothelioma research is commonly focused on end-stage disease. Although disruption of the CDKN2A (INK4A/ARF) locus has been reported in end-stage disease, information is lacking on the status of this key tumor suppressor gene in pleural lesions preceding mesothelioma...
November 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29110521/what-makes-parents-act-and-react-parental-views-and-considerations-relating-to-child-health-during-infancy
#12
Gerd Almqvist-Tangen, Susann Arvidsson, Bernt Alm, Stefan Bergman, Josefine Roswall, Jovanna Dahlgren, Lauri Nevonen
Lifestyle factors and behaviours are adopted very early in life and tend to persist throughout life. Considering that the parents are the primary gatekeepers for their child's health, there is a need to gain more knowledge and deeper understanding about what causes parents to act and react in order for early preventive efforts to have any effect. The aim was to explore the parental views and considerations concerning 'child health' among parents with infants 8-10 months old. The sample was strategic and 16 parents (aged 23-41) were recruited from three child health centres in Sweden...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29108841/a-conceptual-framework-for-understanding-unintended-prolonged-opioid-use
#13
W Michael Hooten, Chad M Brummett, Mark D Sullivan, Jenna Goesling, Jon C Tilburt, Jessica S Merlin, Jennifer L St Sauver, Ajay D Wasan, Daniel J Clauw, David O Warner
An urgent need exists to better understand the transition from short-term opioid use to unintended prolonged opioid use (UPOU). The purpose of this work is to propose a conceptual framework for understanding UPOU that posits the influence of 3 principal domains that include the characteristics of (1) individual patients, (2) the practice environment, and (3) opioid prescribers. Although no standardized method exists for developing a conceptual framework, the process often involves identifying corroborative evidence, leveraging expert opinion to identify factors for inclusion in the framework, and developing a graphic depiction of the relationships between the various factors and the clinical problem of interest...
November 3, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29108499/what-barriers-and-facilitators-do-school-nurses-experience-when-implementing-an-obesity-intervention
#14
Krista Schroeder, Arlene Smaldone
A recent evaluation of a school nurse-led obesity intervention demonstrated a 5% implementation rate. The purpose of this study was to explore school nurses' perceived barriers to and facilitators of the intervention in order to understand reasons for the low implementation rate. Methods included semi-structured individual interviews with school nurses. Data were analyzed using content analysis and heat mapping. Nineteen nurses participated and eight themes were identified. Parental and administrative gatekeeping, heavy nurse workload, obesogenic environments, and concerns about obesity stigma were barriers to implementation...
December 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/29106390/glycolysis-gatekeeper-pdk1-reprograms-breast-cancer-stem-cells-under-hypoxia
#15
F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH(+) subpopulations, decreases stemness-related transcriptional factor expression, and inhibits sphere-formation ability and tumor growth. Conversely, high levels of PDK1 enhance BCSC properties and are correlated with poor overall survival...
November 6, 2017: Oncogene
https://www.readbyqxmd.com/read/29101139/public-views-towards-community-health-and-hospital-based-outpatient-services-and-their-utilisation-in-zhejiang-china-a-mixed-methods-study
#16
Dan Wu, Tai Pong Lam, Kwok Fai Lam, Xu Dong Zhou, Kai Sing Sun
OBJECTIVE: China is engaged in promoting community health services (CHS) nationwide. This study examines the public's views towards CHS and their utilisation of community-based and hospital-based outpatient services. DESIGN: A mixed methods study using qualitative interviews and a cross-sectional survey. STUDY SETTING AND PARTICIPANTS: The study was conducted among the public between September 2014 and September 2015 in Zhejiang province, China...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29101015/dna-damage-metabolism-and-aging-in-pro-inflammatory-t-cells-rheumatoid-arthritis-as-a-model-system
#17
REVIEW
Yinyin Li, Jörg J Goronzy, Cornelia M Weyand
The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration. Inflammation is a common denominator in age-related pathologies, identifying the immune system as a gatekeeper in aging overall. Among immune cells, T cells are long-lived and exposed to intense replication pressure, making them sensitive to aging-related abnormalities. In successful T cell aging, numbers of naïve cells, repertoire diversity and activation thresholds are preserved as long as possible; in maladaptive T cell aging, protective T cell functions decline and pro-inflammatory effector cells are enriched...
November 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29097973/currency-and-competence-of-occupational-therapists-and-consumers-with-rapidly-changing-technology
#18
REVIEW
Emily J Steel, Ricky Buchanan, Natasha Layton, Erin Wilson
Assistive technology was once a specialised field of practice, involving products designed for populations with specific impairments or functional goals. In Australia, occupational therapists have, at times, functioned as gatekeepers to public funding, prescribing products from a predefined list. An expanding range of accessible mainstream products available via international and online markets has changed the meaning and application of assistive technology for many people with disability. In the policy context of consumer choice and cost-effectiveness, have occupational therapists been left behind? This paper describes the change in context for access to assistive technology resulting in expanded possibilities for participation and inclusion...
2017: Occupational Therapy International
https://www.readbyqxmd.com/read/29096075/getting-mrna-containing-ribonucleoprotein-granules-out-of-a-nuclear-back-door
#19
REVIEW
Anup Parchure, Mary Munson, Vivian Budnik
A pivotal feature of long-lasting synaptic plasticity is the localization of RNAs and the protein synthesis machinery at synaptic sites. How and where ribonucleoprotein (RNP) transport granules that support this synthetic activity are formed is of fundamental importance. The prevailing model poses that the nuclear pore complex (NPC) is the sole gatekeeper for transit of cellular material in and out of the nucleus. However, insights from the nuclear assembly of large viral capsids highlight a back door route for nuclear escape, a process referred to nuclear envelope (NE) budding...
November 1, 2017: Neuron
https://www.readbyqxmd.com/read/29094453/uterine-metastasis-of-lung-adenocarcinoma-under-molecular-target-therapy-with-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-a-case-report-and-review-of-the-literature
#20
Mayu Shibata, Masato Shizu, Kazuko Watanabe, Akihiro Takeda
A 63-year-old woman presented with abnormal vaginal bleeding. Her disease history was significant, and included advanced lung adenocarcinoma with a deletion mutation in exon 19 of the epidermal growth factor receptor (EGFR) gene, which was managed by concurrent chemoradiotherapy, followed by molecular targeted therapy with tyrosine kinase inhibitors (TKIs) for a two-year period. Contrast-enhanced computed tomography showed the enlargement of a previously suspicious myoma node, with peripheral enhancement. Hemorrhagic necrosis was also observed on magnetic resonance imaging...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
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