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https://www.readbyqxmd.com/read/28096541/the-mucosal-immune-system-master-regulator-of-bidirectional-gut-brain-communications
#1
REVIEW
Nick Powell, Marjorie M Walker, Nicholas J Talley
Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota-gut-brain axis). We are now starting to understand how perturbation of these systems affects transition between health and disease...
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#2
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28088204/the-ecology-of-medical-care-on-an-isolated-island-in-okinawa-japan-a-retrospective-open-cohort-study
#3
Makoto Kaneko, Masato Matsushima, Greg Irving
BACKGROUND: We aimed to describe the ecology of medical care on an isolated island with limited access to secondary care, and to evaluate the gatekeeping function of the island's primary care clinic through comparison with a previous nationwide survey. METHODS: We conducted this retrospective, open cohort study on Iheya, an isolated island in Okinawa Prefecture that has one primary care clinic. We considered Iheya as unique location in which to examine the role of primary care in Japan...
January 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28087256/manganese-superoxide-dismutase-and-glutathione-peroxidase-1-contribute-to-the-rise-and-fall-of-mitochondrial-reactive-oxygen-species-which-drive-oncogenesis
#4
REVIEW
Dede N Ekoue, Chenxia He, Alan M Diamond, Marcelo G Bonini
Reactive oxygen species (ROS) largely originating in the mitochondria play essential roles in the metabolic and (epi)genetic reprogramming of cancer cell evolution towards more aggressive phenotypes. Recent studies have indicated that the activity of superoxide dismutase (SOD2) may promote tumor progression by serving as a source of hydrogen peroxide (H2O2). H2O2 is a form of ROS that is particularly active as a redox agent affecting cell signaling due to its ability to freely diffuse out of the mitochondria and alter redox active amino acid residues on regulatory proteins...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28078477/information-sharing-challenges-between-adolescents-with-cancer-their-parents-and-health-care-providers-a-qualitative-study
#5
Masoud Bahrami, Mahboobeh Namnabati, Fariborz Mokarian, Parastoo Oujian, Paul Arbon
PURPOSE: We aimed to assess the viewpoints, experiences, and preferences within the clinical communication triangle (parent, adolescent, health care team) concerning the information-sharing process for adolescents with cancer. METHODS: This is a qualitative descriptive-exploratory study. Overall, 33 participants were recruited (adolescents diagnosed with cancer aged 15-20 years, their parents, oncologists, and nurses). In-depth semi-structured interviews were conducted and data were analyzed using constant comparative analysis...
January 11, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28077299/anaplastic-lymphoma-kinase-alk-inhibitors-in-the-treatment-of-alk-driven-lung-cancers
#6
REVIEW
Robert Roskoski
Anaplastic lymphoma kinase is expressed in two-thirds of the anaplastic large-cell lymphomas as an NPM-ALK fusion protein. Physiological ALK is a receptor protein-tyrosine kinase within the insulin receptor superfamily of proteins that participates in nervous system development. The EML4-ALK fusion protein and four other ALK-fusion proteins play a fundamental role in the development in about 5% of non-small cell lung cancers. The amino-terminal portions of the ALK fusion proteins result in dimerization and subsequent activation of the ALK protein kinase domain that plays a key role in the pathogenesis of various tumors...
January 8, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28074336/small-heat-shock-proteins-in-ageing-and-age-related-diseases
#7
REVIEW
Nikolaos Charmpilas, Emmanouil Kyriakakis, Nektarios Tavernarakis
Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology...
January 10, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28074210/diagnostic-value-of-additional-68-ga-psma-pet-before-223-ra-dichloride-therapy-in-patients-with-metastatic-prostate-carcinoma
#8
Axel Bräuer, Kambiz Rahbar, Julia Konnert, Martin Bögemann, Lars Stegger
PURPOSE: Medical imaging plays an important role in selecting patients with metastatic castration-resistant prostate cancer for (223)Ra-dichloride therapy of bone metastases. The purpose of this study was to investigate whether (68)Ga-PSMA-PET has incremental value over conventional imaging for selecting patients suitable for (223)Ra-dichloride therapy. METHODS: In 27 consecutive patients referred for (223)Ra-dichloride therapy additional (68)Ga-PSMA-PET/CT was performed and tracer distribution was evaluated systematically with respect to the detection of visceral metastases and bone metastases with inadequate uptake on bone scintigraphy...
January 11, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28070340/civil-society-engagement-in-multi-stakeholder-dialogue-a-qualitative-study-exploring-the-opinions-and-perceptions-of-meta-members
#9
Gemma L Buckland-Merrett, Catherine Kilkenny, Tim Reed
BACKGROUND: The Medicines Transparency Alliance (MeTA) is an initiative that brings together all stakeholders in the medicines market to create a multi-stakeholder dialogue and improve access, availability and affordability of medicines. Key to this multi-stakeholder dialogue is the participation of Civil Society Organisations. A recent MeTA annual review, identified uneven engagement of civil society organisations in the multi-stakeholder process. This study was designed to explore the engagement of Civil Society Organisations in the MeTA multi-stakeholder process and the factors influencing their participation...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28068109/not-a-mom-thing-predictors-of-gatekeeping-in-same-sex-and-heterosexual-parent-families
#10
Kristin K Sweeney, Abbie E Goldberg, Randi L Garcia
The current study is the first to examine parental gatekeeping in both same-sex (57 female, 51 male) and heterosexual (n = 82) couples, all of whom became parents via adoption. Aspects of the individual, the couple, and the work context, measured preadoption, were examined as predictors of gatekeeping. Gatekeeping refers to attitudes and behaviors aimed at regulating and limiting the involvement of the other parent in housework and child care and was measured 2 years postadoption. Findings revealed that women in heterosexual relationships reported higher gatekeeping compared with all other groups, and men in same-sex relationships reported higher gatekeeping compared with women in same-sex relationships and men in heterosexual relationships...
January 9, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28067380/a-single-light-triggered-and-dual-imaging-guided-multifunctional-platform-for-combined-photothermal-and-photodynamic-therapy-based-on-td-controlled-and-icg-loaded-cus-msio2
#11
Qing You, Qi Sun, Jinping Wang, Xiaoxiao Tan, Xiaojuan Pang, Li Liu, Meng Yu, Fengping Tan, Nan Li
Near-infrared (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and high biological penetration. In this work, we report a novel 1-tetradecanol (TD)-controlled and indocyanine green (ICG)-loaded CuS@mSiO2 phototherapy nanoplatform (CuS@mSiO2-TD/ICG). The CuS@mSiO2 nanoparticles prepared by a facile one-pot approach can serve as drug-delivery vehicles to transport the NIR absorbing phototherapeutic agent (ICG) within the mesoporous cavities. Meanwhile a phase-change molecule (PCM), TD, is introduced as a thermosensitive gatekeeper to avoid the premature release of loaded ICG...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28065755/extended-spectrum-antiprotozoal-bumped-kinase-inhibitors-a-review
#12
Wesley C Van Voorhis, J Stone Doggett, Marilyn Parsons, Matthew A Hulverson, Ryan Choi, Samuel Arnold, Michael W Riggs, Andrew Hemphill, Daniel K Howe, Robert H Mealey, Audrey O T Lau, Ethan A Merritt, Dustin J Maly, Erkang Fan, Kayode K Ojo
Many life-cycle processes in parasites are regulated by protein phosphorylation. Hence, disruption of essential protein kinase function has been explored for therapy of parasitic diseases. However, the difficulty of inhibiting parasite protein kinases to the exclusion of host orthologues poses a practical challenge. A possible path around this difficulty is the use of bumped kinase inhibitors for targeting calcium dependent protein kinases that contain atypically small gatekeeper residues and are crucial for pathogenic apicomplexan parasites' survival and proliferation...
January 5, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28065656/apt2-inhibition-restores-scribble-localization-and-s-palmitoylation-in-snail-transformed-cells
#13
Jeannie L Hernandez, Dahvid Davda, Melanie Cheung See Kit, Jaimeen D Majmudar, Sang Joon Won, Margery Gang, Sirisha C Pasupuleti, Alexandria I Choi, Callie M Bartkowiak, Brent R Martin
The multidomain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell-cell junctions to the cytosol, correlating with enhanced growth signaling and malignancy. Here we confirm that expression of the epithelial-to-mesenchymal transcription factor (EMT-TF) Snail in benign epithelial cells leads to Scrib displacement from the plasma membrane, mimicking the mislocalization observed in aggressive cancers...
January 4, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28062338/family-caregiver-participation-in-palliative-care-research-challenging-the-myth
#14
Samar Aoun, Susan Slatyer, Kathleen Deas, Cheryl Nekolaichuk
BACKGROUND: Despite international guidelines emphasizing consumer directed care and autonomous decisions in research participation, there is a common myth that research can be an additional and unwanted burden on patients and their family members. AIM: to examine the experiences and impact of research involvement on family caregivers (FC) of terminally ill people, focusing within home-based palliative care. DESIGN: and participants: 316 of 322 participants (98...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28062187/dentate-gyrus-autonomous-ictal-activity-in-the-status-epilepticus-rat-model-of-epilepsy
#15
Florian Weissinger, Matthias Wawra, Pawel Fidzinski, Mark Elsner, Hartmut Meierkord, Martin Holtkamp, Katharina Buchheim
The dentate gyrus (DG) as part of the hippocampal formation is believed to serve as a gatekeeper with strong inhibitory properties against uncontrolled propagation of neuronal activity from the entorhinal cortex and neocortical structures. In temporal lobe epilepsy, the DG becomes hyperexcitable and loses its gate function, enabling propagation of ictal activity into downstream structures such as CA3 and CA1 areas. Furthermore, the DG, apart from facilitating propagation, may also be able to autonomously generate ictal activity, but this point has remained open so far...
January 3, 2017: Brain Research
https://www.readbyqxmd.com/read/28061480/co-ordinated-overexpression-of-sirt1-and-stat3-is-associated-with-poor-survival-outcome-in-gastric-cancer-patients
#16
Shu Zhang, Shuling Huang, Chao Deng, Yu Cao, Jun Yang, Guangxia Chen, Bin Zhang, Chaoqin Duan, Jiong Shi, Bo Kong, Helmut Friess, Nanyi Zhao, Chen Huang, Xiaoli Huang, Lei Wang, Xiaoping Zou
In many gastric cancer patients, the disease is diagnosed in an advanced stage and therefore the mortality levels are high. Because there is a need to identify novel early diagnostic and prognostic biomarkers, we tested whether SIRT1 and STAT3 are good candidates. Towards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3) levels using immunohistochemistry...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28054223/what-do-parents-perceive-are-the-barriers-and-facilitators-to-accessing-psychological-treatment-for-mental-health-problems-in-children-and-adolescents-a-systematic-review-of-qualitative-and-quantitative-studies
#17
REVIEW
Tessa Reardon, Kate Harvey, Magdalena Baranowska, Doireann O'Brien, Lydia Smith, Cathy Creswell
A minority of children and adolescents with mental health problems access treatment. The reasons for poor rates of treatment access are not well understood. As parents are a key gatekeeper to treatment access, it is important to establish parents' views of barriers/facilitators to accessing treatment. The aims of this study are to synthesise findings from qualitative and quantitative studies that report parents' perceptions of barriers/facilitators to accessing treatment for mental health problems in children/adolescents...
January 4, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28054134/ultrasonographic-evidence-of-gatekeeper%C3%A2-prosthesis-migration-in-patients-treated-for-faecal-incontinence-a-case-series
#18
F de la Portilla, M L Reyes-Díaz, M V Maestre, R M Jiménez-Rodríguez, A M García-Cabrera, J M Vázquez-Monchul, J M Díaz-Pavón, F C Padillo-Ruiz
BACKGROUND: Faecal incontinence (FI) is both a medical and social problem, with an underestimated incidence. For patients with internal anal sphincter damage, implantation of biomaterial in the anal canal is a recognised treatment option. One such material, Gatekeeper™, has previously shown promising short- and medium-term results without any major complications, including displacement. The main aim of the present study is to assess the degree to which displacement of Gatekeeper prostheses may occur and to determine whether this is associated with patient outcomes...
January 4, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28049724/endonuclease-eepd1-is-a-gatekeeper-for-repair-of-stressed-replication-forks
#19
Hyun-Suk Kim, Jac A Nickoloff, Yuehan Wu, Elizabeth A Williamson, Gurjit Singh Sidhu, Brian L Reinert, Aruna S Jaiswal, Gayathri Srinivasan, Bhavita Patel, Kimi Kong, Sandeep Burma, Suk-Hee Lee, Robert A Hromas
Replication is not as continuous as once thought, with DNA damage frequently stalling replication forks. Aberrant repair of stressed replication forks can result in cell death or genome instability and resulting transformation to malignancy. Stressed replication forks are most commonly repaired via homologous recombination (HR), which begins with end resection, mediated by exonuclease complexes, one of which contains Exo1. However, Exo1 requires free DNA ends upon which to act, and these are not commonly present in non-reversed stalled replication forks...
January 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28049143/the-ruler-protein-escp-of-the-enteropathogenic-escherichia-coli-type-iii-secretion-system-is-involved-in-calcium-sensing-and-secretion-hierarchy-regulation-by-interacting-with-the-gatekeeper-protein-sepl
#20
Lihi Shaulov, Jenia Gershberg, Wanyin Deng, B Brett Finlay, Neta Sal-Man
: The type III secretion system (T3SS) is a multiprotein complex that plays a central role in the virulence of many Gram-negative bacterial pathogens. To ensure that effector proteins are efficiently translocated into the host cell, bacteria must be able to sense their contact with the host cell. In this study, we found that EscP, which was previously shown to function as the ruler protein of the enteropathogenic Escherichia coli T3SS, is also involved in the switch from the secretion of translocator proteins to the secretion of effector proteins...
January 3, 2017: MBio
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