Florian Iser, Felix Hinz, Dirk C Hoffmann, Niklas Grassl, Cansu Güngör, Jochen Meyer, Laura Dörner, Lea Hofmann, Vanessa Kelbch, Kirsten Göbel, Mustafa Ahmed Mahmutoglu, Phillipp Vollmuth, Areeba Patel, Duy Nguyen, Leon D Kaulen, Iris Mildenberger, Katharina Sahm, Kendra Maaß, Kristian W Pajtler, Ganesh M Shankar, Markus Weiler, Brigitte Wildemann, Frank Winkler, Andreas von Deimling, Michael Platten, Wolfgang Wick, Felix Sahm, Tobias Kessler
PURPOSE: Primary central nervous system (CNS) gliomas can be classified by characteristic genetic alterations. In addition to solid tissue obtained via surgery or biopsy, cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) is an alternative source of material for genomic analyses. EXPERIMENTAL DESIGN: We performed targeted next-generation sequencing (NGS) of CSF cfDNA in a representative cohort of 85 patients presenting at two neurooncological centers with suspicion of primary or recurrent glioma...
January 31, 2024: Clinical Cancer Research