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https://www.readbyqxmd.com/read/29750673/quality-of-life-perception-cognitive-function-and-psychological-status-in-a-real-world-population-of-glioblastoma-patients-treated-with-radiotherapy-and-temozolomide-a-single-center-prospective-study
#1
Giuseppe Lombardi, Eleonora Bergo, Paola Del Bianco, Luisa Bellu, Ardi Pambuku, Mario Caccese, Leonardo Trentin, Vittorina Zagonel
BACKGROUND: Health-related quality of life (HRQoL), cognitive function, and psychological status represent an important focus during the treatment of glioblastoma patients. Nevertheless, few randomized, prospective clinical trials have analyzed these factors, and very little is known in the real-clinical world. We evaluated these characteristics in glioblastoma patients treated with standard first-line therapy outside clinical trials. PATIENTS AND METHODS: In total, 111 newly, histologically diagnosed glioblastoma patients treated at our oncology center with radiotherapy and temozolomide were prospectively enrolled...
May 10, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29712519/systematic-review-of-health-economic-studies-in-cranial-neurosurgery
#2
Won Hyung A Ryu, Michael M H Yang, Sandeep Muram, W Bradley Jacobs, Steven Casha, Jay Riva-Cambrin
OBJECTIVE As the cost of health care continues to increase, there is a growing emphasis on evaluating the relative economic value of treatment options to guide resource allocation. The objective of this systematic review was to evaluate the current evidence regarding the cost-effectiveness of cranial neurosurgery procedures. METHODS The authors performed a systematic review of the literature using PubMed, EMBASE, and the Cochrane Library, focusing on themes of economic evaluation and cranial neurosurgery following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines...
May 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29573214/re-irradiation-of-recurrent-gliomas-pooled-analysis-and-validation-of-an-established-prognostic-score-report-of-the-radiation-oncology-group-rog-of-the-german-cancer-consortium-dktk
#3
Stephanie E Combs, Maximilian Niyazi, Sebastian Adeberg, Nina Bougatf, David Kaul, Daniel F Fleischmann, Arne Gruen, Emmanouil Fokas, Claus M Rödel, Franziska Eckert, Frank Paulsen, Oliver Oehlke, Anca-Ligia Grosu, Annekatrin Seidlitz, Annika Lattermann, Mechthild Krause, Michael Baumann, Maja Guberina, Martin Stuschke, Volker Budach, Claus Belka, Jürgen Debus, Kerstin A Kessel
The heterogeneity of high-grade glioma recurrences remains an ongoing challenge for the interdisciplinary neurooncology team. Response to re-irradiation (re-RT) is heterogeneous, and survival data depend on prognostic factors such as tumor volume, primary histology, age, the possibility of reresection, or time between primary diagnosis and initial RT and re-RT. In the present pooled analysis, we gathered data from radiooncology centers of the DKTK Consortium and used it to validate the established prognostic score by Combs et al...
March 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29564490/use-of-fet-pet-in-glioblastoma-patients-undergoing-neurooncological-treatment-including-tumour-treating-fields-initial-experience
#4
Garry Ceccon, Lazaros Lazaridis, Gabriele Stoffels, Marion Rapp, Manuel Weber, Tobias Blau, Phillip Lohmann, Sied Kebir, Ken Herrmann, Gereon R Fink, Karl-Josef Langen, Martin Glas, Norbert Galldiks
PURPOSE: We present our first clinical experience with O-(2-18 F-fluoroethyl)-L-tyrosine (FET) PET in patients with high-grade glioma treated with various neurooncological therapies including tumour-treating fields (TTFields) for the differentiation of tumour progression from treatment-related changes. METHODS: We retrospectively assessed 12 patients (mean age 51 ± 12 years, range 33-72 years) with high-grade glioma (11 glioblastomas, 1 gliosarcoma) in whom the treatment regimen included TTFields and who had undergone FET PET scans for differentiation of tumour progression from treatment-related changes...
March 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29524715/surgeon-annual-and-cumulative-volumes-predict-early-postoperative-outcomes-after-brain-tumor-resection
#5
Rohan Ramakrishna, Wei-Chun Hsu, Jialin Mao, Art Sedrakyan
OBJECTIVE: Surgeon volume has been previously shown to affect patient outcomes. However, data related to neuro-oncologic surgery are limited and do not include neurologic morbidities as an outcomes measure. In this study, we aimed to determine if 5-year surgeon cumulative and annual volumes predict early postoperative outcomes in patients after brain tumor surgery. METHODS: A population-based cohort of patients (n = 10,258) undergoing brain tumor resection between 2005 and 2014 were included for study using the New York Statewide Planning and Research Cooperation System...
March 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29499963/damage-to-the-left-uncinate-fasciculus-is-associated-with-heightened-schizotypal-traits-a-multimodal-lesion-mapping-study
#6
Anne-Laure Lemaitre, Gilles Lafargue, Hugues Duffau, Guillaume Herbet
A growing body of evidence suggests that individuals with pronounced schizotypal traits also display particular neurophysiological and morphological features - notably with regard to left frontotemporal connectivity. However, the studies published to date have focused on subclinical subjects and psychiatric patients, rather than brain-damaged patients. Here, we used the French version of the Schizotypal Personality Questionnaire to assess schizotypal traits in a sample of 97 patients having undergone surgical resection of a diffuse low-grade glioma...
February 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29498571/the-role-of-preoperative-deep-vein-thrombosis-screening-in-neurooncology
#7
Anmol Pandey, Bhaskar Thakur, Florence Hogg, Christian Brogna, Jamie Logan, Roopen Arya, Richard Gullan, Ranjeev Bhangoo, Keyoumars Ashkan
OBJECTIVE Venous thromboembolism (VTE) is a major cause of morbidity in patients undergoing neurosurgical intervention. The authors postulate that the introduction of a routine preoperative deep vein thrombosis (DVT) screening protocol for patients undergoing neurosurgical intervention for brain tumors would result in a more effective diagnosis of DVT in this high-risk subgroup, and subsequent appropriate management of the condition would reduce pulmonary embolism (PE) rates and improve patient outcomes. METHODS The authors conducted a prospective study of 115 adult patients who were undergoing surgical intervention for a brain tumor...
March 2, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29385919/focused-ultrasound-in-neurosurgery-a-historical-perspective
#8
Maya Harary, David J Segar, Kevin T Huang, Ian J Tafel, Pablo A Valdes, G Rees Cosgrove
Focused ultrasound (FUS) has been under investigation for neurosurgical applications since the 1940s. Early experiments demonstrated ultrasound as an effective tool for the creation of intracranial lesions; however, they were limited by the need for craniotomy to avoid trajectory damage and wave distortion by the skull, and they also lacked effective techniques for monitoring. Since then, the development and hemispheric distribution of phased arrays has resolved the issue of the skull and allowed for a completely transcranial procedure...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29383986/neuroprotective-and-tumoricidal-activities-of-cardiac-glycosides-could-oleandrin-be-a-new-weapon-against-stroke-and-glioblastoma
#9
İlhan Elmaci, Ebru Emekli Alturfan, Salih Cengiz, Aysel Ozpinar, Meric A Altinoz
Cardiac glycosides induce a strong immunological cancer cell cytotoxicity, in which the released intracellular components of dying tumor cells (e.g. calreticulin, HMGB1 and ATP) stimulate immunity and help in eradicating cancer. Among the cardiac glycosides, oleandrin is an inhibitor of P-glycoprotein expression and exerts excellent penetration through the blood-brain barrier which also harbors neuroprotective and anti-glioma efficacies. Cardiac glycosides also exert neuroprotective activities, one explanation for such an action is the metabolic arrest as a defense strategy against hypoxia...
February 15, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29328000/conscious-sedation-with-dexmedetomidine-compared-with-asleep-awake-asleep-craniotomies-in-glioma-surgery-an-analysis-of-180-patients
#10
Eric Suero Molina, Stephanie Schipmann, Isabelle Mueller, Johannes Wölfer, Christian Ewelt, Matthias Maas, Benjamin Brokinkel, Walter Stummer
OBJECTIVE Awake craniotomies have become a feasible tool over time to treat brain tumors located in eloquent regions. Different techniques have been applied in neurooncology centers. Both "asleep-awake-asleep" (asleep) and "conscious sedation" were used subsequently at the authors' neurosurgical department. Since 2013, the authors have only performed conscious sedation surgeries, predominantly using the α2-receptor agonist dexmedetomidine as the anesthetic drug. The aim of this study was to compare both mentioned techniques and evaluate the clinical use of dexmedetomidine in the setting of awake craniotomies for glioma surgery...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29204198/profile-and-outcome-of-pediatric-brain-tumors-experience-from-a-tertiary-care-pediatric-oncology-unit-in-south-india
#11
Supriya Gujjar Suresh, Arathi Srinivasan, Julius Xavier Scott, Santosh Mohan Rao, Balasubramaniam Chidambaram, Sanjay Chandrasekar
Context: Tumors of the central nervous system (CNS) constitute the second most common pediatric cancers. Unlike leukemia, management of CNS tumors requires a good multidisciplinary team. Higher rates of treatment abandonment are documented in view of complexity of the treatment with long duration, involving neurosurgery, radiation, chemotherapy, and high cost of treatment. Morbidity associated with CNS tumors may be significant in terms of physical deficits as well as neuropsychological and neuroendocrine sequelae...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29199818/precision-medicine-in-pediatric-neurooncology-a-review
#12
Aaron Y Mochizuki, Isaura M Frost, Melina B Mastrodimos, Ashley S Plant, Anthony C Wang, Theodore B Moore, Robert M Prins, Paul S Weiss, Steven J Jonas
Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects...
January 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29026945/tspo-pet-using-18-f-ge-180-a-new-perspective-in-neurooncology
#13
EDITORIAL
Karl-Josef Langen, Antje Willuweit
No abstract text is available yet for this article.
December 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29016845/pediatric-low-grade-gliomas-next-biologically-driven-steps
#14
David T W Jones, Mark W Kieran, Eric Bouffet, Sanda Alexandrescu, Pratiti Bandopadhayay, Miriam Bornhorst, David Ellison, Jason Fangusaro, Michael J Fisher, Nicholas Foreman, Maryam Fouladi, Darren Hargrave, Cynthia Hawkins, Nada Jabado, Maura Massimino, Sabine Mueller, Giorgio Perilongo, Antoinette Y N Schouten van Meeteren, Uri Tabori, Katherine Warren, Angela J Waanders, David Walker, William Weiss, Olaf Witt, Karen Wright, Yuan Zhu, Daniel C Bowers, Stefan M Pfister, Roger J Packer
Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neuro-oncology due to comorbidities associated with these tumors and/or their treatments, and their propensity to multiply recurs. LGGs, in total the most common brain tumors arising in childhood, can often become a chronic problem requiring decades of management. The Second International Consensus Conference on Pediatric Low-Grade Gliomas held in Padua, Italy in 2016 was convened in an attempt to advance the pace of translating biological discoveries on LGGs into meaningful clinical benefit...
January 22, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/28990813/glioblastoma-of-pineal-region-report-of-four-cases-and-literature-review
#15
Enrique Orrego, Sandro Casavilca, Pamela Garcia-Corrochano, Sugey Rojas-Meza, Miluska Castillo, Carlos A Castaneda
We report four cases of glioblastoma in the pineal region. The patients presented a severe headache and vomiting. Brain imaging showed a heterogeneously enhanced tumor in the pineal region with obstructive hydrocephalus. Case 3 developed a subependymal dissemination. The patient went to ventricular-peritoneal shunt and subtotal or total resection and radiotherapy with/without chemotherapy. Cases 1 and 2 received radiation and died 8 and 11 later months. Cases 3 and 4 completed radiotherapy and chemotherapy, and survived 28 and 31 months after the initial diagnosis...
October 2017: CNS Oncology
https://www.readbyqxmd.com/read/28936429/clinical-pet-mri-in-neurooncology-opportunities-and-challenges-from-a-single-institution-perspective
#16
REVIEW
Lisbeth Marner, Otto M Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
PURPOSE: Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating malignant from benign lesions. Further, supplemental imaging with amino acid positron emission tomography (PET) has been shown to increase accuracy significantly and is used routinely at an increasing number of sites...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28915414/evaluation-of-surgical-decision-making-and-resulting-outcome-in-patients-with-highly-eloquent-glioblastoma-results-of-a-multicenter-assessment
#17
Jan Coburger, Mirjam Renovanz, Oliver Ganslandt, Florian Ringel, Christian Rainer Wirtz, Javier Segovia von Riehm
INTRODUCTION: Treatment of glioblastoma(GB) patients amenable only for a subtotal resection(STR) is controversial. Since outcome of patients is affected by surgical management, our aim was to assess surgical decision making and resulting outcome in patients with highly eloquent GBs. PATIENTS AND METHODS: We retrospectively assessed GB patients with intended sub-total resection (STR) or stereotactic biopsy (STX) of 3 neurooncological centers operated between 2008 and 2013...
November 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28835855/chemotherapeutic-xct-inhibitors-sorafenib-and-erastin-unraveled-with-the-synaptic-optogenetic-function-analysis-tool
#18
Marc Dahlmanns, Eduard Yakubov, Daishi Chen, Tina Sehm, Manfred Rauh, Nicolai Savaskan, Jana Katharina Wrosch
In the search for new potential chemotherapeutics, the compounds' toxicity to healthy cells is an important factor. The brain with its functional units, the neurons, is especially endangered during the radio- and chemotherapeutic treatment of brain tumors. The effect of the potential compounds not only on neuronal survival but also neuronal function needs to be taken into account. Therefore, in this study we aimed to comprehend the biological effects of chemotherapeutic xCT inhibition on healthy neuronal cells with our synaptic optogenetic function analysis tool (SOFA)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28814253/pet-mr-tomographs-a-review-with-technical-radiochemical-and-clinical-perspectives
#19
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
BACKGROUND AND OBJECTIVE: In the last decade, an increasing number of positron emission tomography / magnetic resonance (PET/MR) tomographs were installed and many clinical studies were performed in the neurological field. METHODS: Although PET/MR has many favorable properties to support the application in brain imaging, attenuation correction, and therefore accurate quantification, is a problem that still requires optimal solution. RESULTS: In this review we have summarized the three main methods that are currently used to correct attenuation in PET/MR, namely atlas- or template-based methods, segmentation-based methods, and reconstruction-based methods...
November 10, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28812012/spinal-cord-injury-due-to-tumour-or-metastasis-in-arag%C3%A3-n-northeastern-spain-1991-2008-incidence-time-trends-and-neurological-function
#20
Maayken Elizabeth Louise van den Berg, Juan M Castellote, Jose Ignacio Mayordomo, Ignacio Mahillo-Fernandez, Jesus de Pedro-Cuesta
PURPOSE: Understanding the presentation of spinal cord injury (SCI) due to tumours considering population distribution and temporal trends is key to managing SCI health services. This study quantified incidence rates, function scores, and trends of SCI due to tumour or metastasis over an 18-year time period in a defined region in Spain. METHODS: A retrospective cohort study included in-and outpatients with nontraumatic SCI due to tumour or metastasis admitted to a metropolitan hospital in Spain between 1991 and 2008...
2017: BioMed Research International
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