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tick-borne encephalitis

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https://www.readbyqxmd.com/read/28919548/reconsidering-the-classification-of-tick-borne-encephalitis-virus-within-the-siberian-subtype-gives-new-insights-into-its-evolutionary-history
#1
S Y Kovalev, T A Mukhacheva
Tick-borne encephalitis is widespread in Eurasia and transmitted by Ixodes ticks. Classification of its causative agent, tick-borne encephalitis virus (TBEV), includes three subtypes, namely Far-Eastern, European, and Siberian (TBEV-Sib), as well as a group of 886-84-like strains with uncertain taxonomic status. TBEV-Sib is subdivided into three phylogenetic lineages: Baltic, Asian, and South-Siberian. A reason to reconsider TBEV-Sib classification was the analysis of 186 nucleotide sequences of an E gene fragment submitted to GenBank during the last two years...
September 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28915259/a-novel-mechanism-of-antibody-mediated-enhancement-of-flavivirus-infection
#2
Denise Haslwanter, Dieter Blaas, Franz X Heinz, Karin Stiasny
Antibody-dependent enhancement of viral infection is a well-described phenomenon that is based on the cellular uptake of infectious virus-antibody complexes following their interaction with Fcγ receptors expressed on myeloid cells. Here we describe a novel mechanism of antibody-mediated enhancement of infection by a flavivirus (tick-borne encephalitis virus) in transformed and primary human cells, which is independent of the presence of Fcγ receptors. Using chemical cross-linking and immunoassays, we demonstrate that the monoclonal antibody (mab) A5, recognizing an epitope at the interface of the dimeric envelope protein E, causes dimer dissociation and leads to the exposure of the fusion loop (FL)...
September 15, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28894041/analysis-of-the-relationship-between-single-nucleotide-polymorphism-of-the-cd209-il-10-il-28-and-ccr5-d32-genes-with-the-human-predisposition-to-developing-tick-borne-encephalitis
#3
Piotr Czupryna, Miłosz Parczewski, Sambor Grygorczuk, Sławomir Pancewicz, Joanna Zajkowska, Justyna Dunaj, Maciej Kondrusik, Katarzyna Krawczuk, Anna Moniuszko-Malinowska
<b>Introduction: </b>It is known that in the pathogenesis of tick-borne encephalitis (TBE) various molecules play a significant role. The most prominent factors include IL-10, IL-28B, CD-209 and CCR5. It is reasonable to search for genetic predispositions to the development of various clinical forms of TBE related to the genetic variation of IL-10, IL-28B, CD-209 and CCR5. In this study we aimed to search for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Δ 32) with the human predisposition to development of various clinical presentations of TBE...
January 4, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#4
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
September 5, 2017: Intervirology
https://www.readbyqxmd.com/read/28830948/flavivirus-infection-of-ixodes-scapularis-black-legged-tick-ex-vivo-organotypic-cultures-and-applications-for-disease-control
#5
Jeffrey M Grabowski, Konstantin A Tsetsarkin, Dan Long, Dana P Scott, Rebecca Rosenke, Tom G Schwan, Luwanika Mlera, Danielle K Offerdahl, Alexander G Pletnev, Marshall E Bloom
Ixodes scapularis ticks transmit many infectious agents that cause disease, including tick-borne flaviviruses (TBFVs). TBFV infections cause thousands of human encephalitis cases worldwide annually. In the United States, human TBFV infections with Powassan virus (POWV) are increasing and have a fatality rate of 10 to 30%. Additionally, Langat virus (LGTV) is a TBFV of low neurovirulence and is used as a model TBFV. TBFV replication and dissemination within I. scapularis organs are poorly characterized, and a deeper understanding of virus biology in this vector may inform effective countermeasures to reduce TBFV transmission...
August 22, 2017: MBio
https://www.readbyqxmd.com/read/28830430/tick-borne-encephalitis-in-a-naturally-infected-sheep
#6
Brigitte Böhm, Benjamin Schade, Benjamin Bauer, Bernd Hoffmann, Donata Hoffmann, Ute Ziegler, Martin Beer, Christine Klaus, Herbert Weissenböck, Jens Böttcher
BACKGROUND: Tick-borne encephalitis (TBE) is the most important viral tick borne zoonosis in Europe. In Germany, about 250 human cases are registered annually, with the highest incidence reported in the last years coming from the federal states Bavaria and Baden-Wuerttemberg. In veterinary medicine, only sporadic cases in wild and domestic animals have been reported; however, a high number of wild and domestic animals have tested positive for the tick-borne encephalitis virus (TBEV) antibody...
August 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28829131/lipid-phase-control-and-secondary-structure-of-viral-fusion-peptides-anchored-in-monoolein-membranes
#7
Artem Levin, Christoph Jeworrek, Roland Winter, Katrin Weise, Claus Czeslik
The fusion of lipid membranes involves major changes of the membrane curvatures and is mediated by fusion proteins that bind to the lipid membranes. For a better understanding of the way fusion proteins steer this process, we have studied the interaction of two different viral fusion peptides, HA2-FP and TBEV-FP, with monoolein mesophases as a function of temperature and pressure at limited hydration. The fusion peptides are derived from the influenza virus hemagglutinin fusion protein (HA2-FP) and from the tick-borne encephalitis virus envelope glycoprotein E (TBEV-FP)...
August 31, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28827760/protein-structure-shapes-immunodominance-in-the-cd4-t-cell-response-to-yellow-fever-vaccination
#8
Maximilian Koblischke, Maria S Mackroth, Julia Schwaiger, Ingrid Fae, Gottfried Fischer, Karin Stiasny, Franz X Heinz, Judith H Aberle
The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles internalized and processed by E-specific B cells. The CD4 T helper cell response is restricted to few immunodominant epitopes, but the mechanisms of their selection are largely unknown. Here, we report that CD4 T cell responses elicited by the YF-17D vaccine are focused to hotspots of two helices of the viral capsid protein and to exposed strands and loops of E...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814513/escape-of-tick-borne-flavivirus-from-2-c-methylated-nucleoside-antivirals-is-mediated-by-a-single-conservative-mutation-in-ns5-that-has-a-dramatic-effect-on-viral-fitness
#9
Ludek Eyer, Hirofumi Kondo, Darina Zouharova, Minato Hirano, James J Valdés, Memi Muto, Tomas Kastl, Shintaro Kobayashi, Jan Haviernik, Manabu Igarashi, Hiroaki Kariwa, Marketa Vaculovicova, Jiri Cerny, Rene Kizek, Andrea Kröger, Stefan Lienenklaus, Milan Dejmek, Radim Nencka, Martin Palus, Jiri Salat, Erik De Clercq, Kentaro Yoshii, Daniel Ruzek
Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2' -C-methyladenosine (7-deaza-2' -CMA), substantially improved disease outcome, increased survival, and reduced signs of neuroinfection and viral titers in the brains of mice infected with a lethal dose of TBEV. To investigate the mechanism of action of 7-deaza-2' -CMA, two drug-resistant TBEV clones were generated and characterized...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28791941/predictability-of-tick-borne-encephalitis-fluctuations
#10
P Zeman
Tick-borne encephalitis is a serious arboviral infection with unstable dynamics and profound inter-annual fluctuations in case numbers. A dependable predictive model has been sought since the discovery of the disease. The present study demonstrates that four superimposed cycles, approximately 2·4, 3, 5·4, and 10·4 years long, can account for three-fifths of the variation in the disease fluctuations over central Europe. Using harmonic regression, these cycles can be projected into the future, yielding forecasts of sufficient accuracy for up to 4 years ahead...
August 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28791846/serum-carnitine-and-acyl-carnitine-in-patients-with-meningitis-due-to-tick-borne-encephalitis-virus-infection
#11
Alina Kępka, Roman M Janas, Sławomir A Pancewicz, Renata Świerzbińska
BACKGROUND: Hard ticks are the main vectors of tick-borne encephalitis virus (TBEV). Free carnitine (FC) and acylcarnitines (AC) have the basic role in β-oxidation as well as the modulation of immune and nervous system. Homeostasis of carnitines in the TBE patients was not studied so far. OBJECTIVES: This study aimed to evaluate FC and AC serum concentrations in patients with meningitis due to TBEV infection before and after 14 ± 3 days of treatment. MATERIAL AND METHODS: The study was performed in 14 patients aged 48 ± 29 years that were divided a posteriori (based on their FC level before and after treatment) into 2 subgroups: 1-8 and 9-14...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28770638/systematic-literature-review-comparing-rapid-3-dose-administration-of-the-gsk-tick-borne-encephalitis-vaccine-with-other-primary-immunization-schedules
#12
Ilaria Galgani, Eveline M Bunge, Lisa Hendriks, Christopher Schludermann, Cinzia Marano, Laurence De Moerlooze
Tick-borne encephalitis (TBE), which is endemic across large regions of Europe and Asia, is most effectively prevented through vaccination. Three-dose primary TBE vaccination schedules are either rapid (0,7,21-days) or conventional (0,28-84-days, 9-12-months). The second dose can also be administered at 14 days for faster priming and sero-protection). Areas covered: We used a three-step selection process to identify 21 publications comparing the immunogenicity and/or safety of different schedules. Expert commentary: Priming with two or three TBE vaccine doses was highly immunogenic...
September 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28768435/cycluridine-a-novel-antiviral-effective-against-flaviviruses
#13
REVIEW
Angel S Galabov, Lucia Mukova, Yuriy P Abashev, Lilia Wassilewa, Petko Tzvetkov, Vassil Minkov, Igor F Barinskiy, Charles M Rice, Sergey Ouzounov, Dorotea Sidzhakova
This review describes the contemporary state of research for antivirals effective against flaviviruses, especially focusing on inhibitors of the pestivirus causative agent of bovine viral diarrhoea virus. We highlight cycluridine, an originally synthesized Mannich's base [a tetrahydro-2(1H)-pyrimidinones derivative], as a highly effective antiviral possessing a strong inhibitory effect on bovine viral diarrhoea virus replication. Cycluridine was active against replication of a wide variety of bovine viral diarrhoea virus strains in cell cultures...
August 2017: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/28762591/ean-consensus-review-on-prevention-diagnosis-and-management-of-tick-borne-encephalitis
#14
REVIEW
P Taba, E Schmutzhard, P Forsberg, I Lutsar, U Ljøstad, Å Mygland, I Levchenko, F Strle, I Steiner
BACKGROUND AND PURPOSE: Tick-borne encephalitis (TBE) is an infection of the central nervous system (CNS) caused by tick-borne encephalitis virus (TBEV) and transmitted by ticks, with a variety of clinical manifestations. The incidence of TBE in Europe is increasing due to an extended season of the infection and the enlargement of endemic areas. Our objectives are to provide recommendations on the prevention, diagnosis and management of TBE, based on evidence or consensus decisions. METHODS: For systematic evaluation, the literature was searched from 1970 to 2015 (including early online publications of 2016), and recommendations were based on evidence or consensus decisions of the Task Force when evidence-based data were not available...
August 1, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28755284/morphological-anomalies-in-ixodes-ricinus-and-ixodes-inopinatus-collected-from-tick-borne-encephalitis-natural-foci-in-central-europe
#15
Lidia Chitimia-Dobler, Malena Bestehorn, Michael Bröker, Johannes Borde, Tomas Molcanyi, Nanna Skaarup Andersen, Martin Pfeffer, Gerhard Dobler
In 2015, 0.02% nymphs displayed anomalies (ectromely) out of the 6744 collected ticks as part of a tick-borne encephalitis program in Germany. In 2016, questing Ixodes ricinus (n = 14,527) and Ixodes inopinatus (n = 75) ticks were collected by flagging as part of a tick-borne encephalitis program in Germany, Slovakia and Denmark. A total of 278 (1.9%) out of 14,602 nymph and adult ticks showed morphological anomalies. The anomalies were divided into general anomalies (body asymmetry) and local anomalies (anomalies of appendages, malformation of capitulum, exoskeleton anomalies and anal groove deformation) with nymphs being the most affected life stage...
July 28, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28741465/engineering-of-chimeric-protein-based-on-e-protein-domain-iii-of-tick-borne-encephalitis-virus-and-ompf-porin-of-yersinia-pseudotuberculosis
#16
Anna M Stenkova, Natalia S Chopenko, Ludmila A Davydova, Andrey N Mazeika, Evgeniya P Bystritskaya, Olga Y Portnyagina, Stanislav D Anastyuk, Dmitrii S Kulbatskii, Ekaterina N Lyukmanova, Dmitriy A Dolgikh, Eduard Y Kostetsky, Nina M Sanina
Tick-borne encephalitis poses a serious public health threat in the endemic regions. The disease treatment is restricted to symptomatic therapy, so great expectations are in the development of the prophylactic and therapeutic vaccines. The domain III of E protein of the tick-borne encephalitis virus is the main antigenic domain which includes virus-specific epitopes recognized by neutralizing antibodies. We have expressed, isolated and characterized the chimeric protein based on the fusion of domain III of E protein of the tick-borne encephalitis virus and bacterial porin OmpF from Yersinia pseudotuberculosis...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#17
REVIEW
Francisco Javier Carod Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
July 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28728557/the-impact-of-illegal-waste-sites-on-a-transmission-of-zoonotic-viruses
#18
Darja Duh, Sandra Hasic, Elena Buzan
BACKGROUND: Illegal waste disposal impacts public health and causes aesthetic and environmental pollution. Waste disposed in places without permitted and controlled facilities can provide a ready source of nutrition and shelter for rodents and thus promote the spread of their ecto- and endoparasites. The presence of two distinct zoonotic viruses, lymphocytic choriomeningitis virus (LCMV) and tick-borne encephalitis virus (TBEV), was searched at illegal waste sites. The aim of this study was to determine the prevalence of infection with both viruses in rodents and to discuss the virus-rodent relations in such environments...
July 20, 2017: Virology Journal
https://www.readbyqxmd.com/read/28714929/synchronous-langat-virus-infection-of-haemaphysalis-longicornis-using-anal-pore-microinjection
#19
Melbourne Rio Talactac, Kentaro Yoshii, Emmanuel Pacia Hernandez, Kodai Kusakisako, Remil Linggatong Galay, Kozo Fujisaki, Masami Mochizuki, Tetsuya Tanaka
The tick-borne encephalitis virus (TBEV) serocomplex of flaviviruses consists of arboviruses that cause important diseases in animals and humans. The transmission of this group of viruses is commonly associated with tick species such as Ixodes spp., Dermacentor spp., and Hyalomma spp. In the case of Haemaphysalis longicornis, the detection and isolation of flaviviruses have been previously reported. However, studies showing survival dynamics of any tick-borne flavivirus in H. longicornis are still lacking. In this study, an anal pore microinjection method was used to infect adult H...
July 17, 2017: Viruses
https://www.readbyqxmd.com/read/28705180/etiology-and-prognosis-of-acute-viral-encephalitis-and-meningitis-in-chinese-children-a-multicentre-prospective-study
#20
Junhong Ai, Zhengde Xie, Gang Liu, Zongbo Chen, Yong Yang, Yuning Li, Jing Chen, Guo Zheng, Kunling Shen
BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5...
July 14, 2017: BMC Infectious Diseases
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