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tick-borne encephalitis

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https://www.readbyqxmd.com/read/29763485/what-s-eating-you-ixodes-tick-and-related-diseases-part-2-diagnosis-and-treatment-of-regional-tick-borne-diseases
#1
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, Borrelia miyamotoi disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29760190/tick-borne-encephalitis-virus-nonstructural-protein-ns5-induces-rantes-expression-dependent-on-the-rna-dependent-rna-polymerase-activity
#2
Zifeng Zheng, Jieyu Yang, Xuan Jiang, Yalan Liu, Xiaowei Zhang, Mei Li, Mudan Zhang, Ming Fu, Kai Hu, Hanzhong Wang, Min-Hua Luo, Peng Gong, Qinxue Hu
Tick-borne encephalitis virus (TBEV) is one of the flaviviruses that targets the CNS and causes encephalitis in humans. The mechanism of TBEV that causes CNS destruction remains unclear. It has been reported that RANTES-mediated migration of human blood monocytes and T lymphocytes is specifically induced in the brain of mice infected with TBEV, which causes ensuing neuroinflammation and may contribute to brain destruction. However, the viral components responsible for RANTES induction and the underlying mechanisms remain to be fully addressed...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29745301/comparative-genome-analysis-of-alkhumra-hemorrhagic-fever-virus-with-kyasanur-forest-disease-and-tick-borne-encephalitis-viruses-by-the-in-silico-approach
#3
Navaneethan Palanisamy, Dario Akaberi, Johan Lennerstrand, Åke Lundkvist
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis virus (TBEV). Currently, very little is known about the pathologies of AHFV. In this study, using the available genome information of AHFV, KFDV and TBEV, we have predicted and compared the following aspects of these viruses: evolution, nucleotide and protein compositions, recombination, codon frequency, substitution rate, N- and O-glycosylation sites, signal peptide and cleavage site, transmembrane region, secondary structure of 5' and 3' UTRs and RNA-RNA interactions...
May 10, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29742014/complete-genomic-characterization-of-three-tick-borne-encephalitis-viruses-detected-along-the-china-north-korea-border-2011
#4
Xiaoxia He, Junwei Zhao, Shihong Fu, Lisi Yao, Xiaoyan Gao, Yan Liu, Ying He, Guodong Liang, Huanyu Wang
Tick-borne encephalitis virus (TBEV) causes neurological infections with serious sequelae in Europe and Northeast Asia. In China, the major epidemic areas are along the borders with Russia and North Korea. Although several TBEV isolates have been reported, the biological characteristics of the Chinese strains, especially those along the China-North Korea border, are unclear. In this study, we detected seven TBEV fragment sequences in 602 adult Dermacentor silvarum collected in the Changbai Mountain area of Jilin Province on the China-North Korea border and characterized the genome of three TBEV strains (JLCB11-08, JLCB11-35, and JLCB11-40)...
May 9, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29718024/what-s-eating-you-ixodes-tick-and-related-diseases-part-1-life-cycle-local-reactions-and-lyme-disease
#5
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. This 3-part review highlights the biology of the Ixodes tick and manifestations of related diseases. Part 1 addresses the Ixodes tick biology and life cycle; local reactions; and Lyme disease, the most prevalent of associated diseases. Part 2 will address human granulocytic anaplasmosis, babesiosis, Powassan virus infection, Borrelia miyamotoi disease, tick-borne encephalitis, and tick paralysis. Part 3 will address coinfection with multiple pathogens as well as methods of tick-bite prevention and tick removal...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29713635/detection-of-tick-borne-pathogens-in-lambs-undergoing-prophylactic-treatment-against-ticks-on-two-swedish-farms
#6
Giulio Grandi, Anna Aspán, Jenny Pihl, Katarina Gustafsson, Fredrik Engström, Tomas Jinnerot, Robert Söderlund, Jan Chirico
Tick-borne pathogens (TBPs), especially Anaplasma phagocytophilum , cause disease in grazing livestock. Tick prophylaxis is, therefore, a routine practice in sheep flocks in Sweden, especially in central, southern, and coastal areas of the country where ixodid ticks ( Ixodes ricinus and Haemaphysalis punctata ) are present. In the present study, the status of infection by A. phagocytophilum and other TBPs in lambs treated with tick prophylaxis has been assessed serologically and with polymerase chain reaction (PCR)...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29709065/probing-chemical-space-of-tick-borne-encephalitis-virus-reproduction-inhibitors-with-organoselenium-compounds
#7
Alexey A Orlov, Anastasia A Eletskaya, Konstantin A Frolov, Anastasia D Golinets, Vladimir A Palyulin, Sergey G Krivokolysko, Liubov I Kozlovskaya, Victor V Dotsenko, Dmitry I Osolodkin
Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4-(alkylthio)-2-aryl-3-azaspiro[5...
April 30, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29705691/cxcl13-concentrations-in-cerebrospinal-fluid-of-patients-with-lyme-neuroborreliosis-and-other-neurological-disorders-determined-by-luminex-and-elisa
#8
Mateusz Markowicz, Anna-Margarita Schötta, Michael Kundi, Petra Bogovič, Katarina Ogrinc, Franc Strle, Gerold Stanek
The aims of the study were to determine and compare the concentration of CXCL13 in cerebrospinal fluid (CSF) of patients with Lyme neuroborreliosis (LNB) and various other neurological disorders applying a Luminex based assay and ELISA, and to find factors associated with CXCL13 concentration. CSF samples obtained from four clinically well-defined groups of patients (proven LNB, suspected LNB, tick-borne encephalitis (TBE), and aseptic meningitis/meningoencephalitis other than TBE) - 25 samples per group - were analyzed...
April 20, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29701628/seroprevalence-survey-of-arboviruses-in-workers-from-tuscany-italy
#9
Maria Elena Remoli, Cristiano Fiorentini, Antonella Marchi, Simona Di Renzi, Nicoletta Vonesch, Maria Vittoria Peri, Lucia Bastianini, Silvia Rossi, Giulia Bartoccini, Maya Lissa Kuttappasery, Maria Grazia Ciufolini, Paola Tomao
BACKGROUND: Arthropod-borne viruses (Arbovirus) play an important role among emerging and re-emerging infectious diseases and in the spreading of infections in new geographic areas. Although some arboviral infections may be asymptomatic or mild flu-like illnesses, many occur as severe forms of meningitis and meningoencephalitis. OBJECTIVES: To assess whether arboviral infections may be associated with occupational risk, in a population of agricultural and forestry workers potentially at high risk for arthropods bite and sting...
January 30, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#10
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29691370/a-new-subtype-of-eastern-tick-borne-encephalitis-virus-discovered-in-qinghai-tibet-plateau-china
#11
Xiaoyi Dai, Guobao Shang, Shan Lu, Jing Yang, Jianguo Xu
Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). Two complete genomes of TBEV were obtained from respiratory samples of 200 marmots. The phylogenetic analysis using the E protein and polyprotein demonstrated that the two strains of Him-TBEV formed an independent branch, separated from Eu-TBEV, Sib-TBEV, and FE-TBEV...
April 25, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29678403/tick-borne-encephalitis-virus-borrelia-burgdorferi-sensu-lato-borrelia-miyamotoi-anaplasma-phagocytophilum-and-candidatus-neoehrlichia-mikurensis-in-ixodes-ricinus-ticks-collected-from-recreational-islands-in-southern-norway
#12
Vivian Kjelland, Katrine M Paulsen, Rikke Rollum, Andrew Jenkins, Snorre Stuen, Arnulf Soleng, Kristin S Edgar, Heidi H Lindstedt, Kirsti Vaino, Moustafa Gibory, Åshild K Andreassen
The aim of this study was to determine the occurrence of tick-borne pathogens of medical importance in questing ticks collected from five recreationally used islands along the Norwegian coastline. Furthermore, since coinfection may affect the disease severity, this study aimed to determine the extent of coinfection in individual ticks or co-localization of tick-borne pathogens. In all, 4158 questing Ixodes ricinus ticks were analyzed. For detection of tick-borne encephalitis virus (TBEV), nymphs (3690) were analyzed in pools of ten...
April 12, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29678401/geographical-distribution-climate-adaptation-and-vector-competence-of-the-eurasian-hard-tick-haemaphysalis-concinna
#13
Franz Rubel, Katharina Brugger, Melanie Walter, Janna R Vogelgesang, Yuliya M Didyk, Su Fu, Olaf Kahl
The ixodid tick Haemaphysalis concinna Koch, 1844 is a proven vector of tick-borne encephalitis (TBE) virus and Francisella tularensis, the causative agent of tularaemia. In the present study, up-to-date maps depicting the geographical distribution and climate adaptation of H. concinna are presented. A dataset was compiled, resulting in 656 georeferenced locations in Eurasia. The distribution of H. concinna ranges from the Spanish Atlantic coast to Kamchatka, Russia, within the belt of 28-64° N latitude...
April 10, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29678185/the-intrathecal-expression-and-pathogenetic-role-of-th17-cytokines-and-cxcr2-binding-chemokines-in-tick-borne-encephalitis
#14
Sambor Grygorczuk, Renata Świerzbińska, Maciej Kondrusik, Justyna Dunaj, Piotr Czupryna, Anna Moniuszko, Agnieszka Siemieniako, Sławomir Pancewicz
BACKGROUND: Tick-borne encephalitis (TBE) is a clinically variable but potentially severe Flavivirus infection, with the outcome strongly dependent on secondary immunopathology. Neutrophils are present in cerebrospinal fluid (CSF) of TBE patients, but their pathogenetic role remains unknown. In animal models, neutrophils contributed both to the Flavivirus entry into central nervous system (CNS) and to the control of the encephalitis, which we attempted to evaluate in human TBE. METHODS: We analyzed records of 240 patients with TBE presenting as meningitis (n = 110), meningoencephalitis (n = 114) or meningoencephalomyelitis (n = 16) assessing CSF neutrophil count on admission and at follow-up 2 weeks later, and their associations with other laboratory and clinical parameters...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29673942/allergic-patients-with-and-without-allergen-specific-immunotherapy-mount-protective-immune-responses-to-tick-borne-encephalitis-vaccination-in-absence-of-enhanced-side-effects-or-propagation-of-their-th2-bias
#15
Erika Garner-Spitzer, Claudia Seidl-Friedrich, Ines Zwazl, Michael Hofer, Tamar Kinaciyan, Reinhart Jarisch, Karin Stiasny, Gerhard J Zlabinger, Michael Kundi, Ursula Wiedermann
BACKGROUND: Allergic diseases are caused by Th2-driven immune responses and their treatment with specific immunotherapy (SIT) leads to immunomodulation via IL10, TGF-ß and Th1/Tr1 shift. This phase IV, open-label clinical trial investigated whether allergies and SIT treatment influenced immune responses to routine vaccination. METHODS: We studied three groups: 49 allergic patients (allergic group), 21 allergic patients receiving maintenance doses of SIT (SIT group), and 49 non-allergic controls...
May 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29669948/survey-of-tick-borne-zoonotic-viruses-in-wild-deer-in-hokkaido-japan
#16
Leo Uchida, Daisuke Hayasaka, Mya Myat Ngwe Tun, Kouichi Morita, Yasukazu Muramatsu, Katsuro Hagiwara
Tick-borne encephalitis (TBE) and severe fever with thrombocytopenia syndrome (SFTS) are both tick-borne zoonotic diseases caused by TBE virus (TBEV) and SFTS phlebovirus (SFTSV). In 2016, a second domestic TBE case was reported in Hokkaido, Japan, after an absence of 23 years. We conducted IgG ELISA for TBEV and SFTSV on 314 deer (Cervus nippon yesoensis) serum samples collected from 3 places in Hokkaido. There were 7 seropositive samples for TBEV but none for SFTSV by ELISA. The specificity of the 7 positive samples was confirmed by neutralization tests against TBEV, and 5 sera showed 320 to 640 of 50% focus reduction endpoint titers...
April 19, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29667575/a-cluster-of-two-human-cases-of-tick-borne-encephalitis-tbe-transmitted-by-unpasteurised-goat-milk-and-cheese-in-germany-may-2016
#17
S O Brockmann, R Oehme, T Buckenmaier, M Beer, A Jeffery-Smith, M Spannenkrebs, S Haag-Milz, C Wagner-Wiening, C Schlegel, J Fritz, S Zange, M Bestehorn, A Lindau, D Hoffmann, S Tiberi, U Mackenstedt, G Dobler
In May 2016, two cases of tick-borne encephalitis (TBE) were confirmed by serology (positive IgM and IgG antibodies against TBE virus (TBEV) in serum), with a possible link to raw milk and cheese from a goat farm in a region in Baden-Württemberg, Germany not previously known as TBE-endemic. The outbreak investigation identified 32 consumers of goat dairy products (29 consumers, one farm employee, two owners) of whom none had IgM antibodies against TBEV 3-8 weeks after consumption. Of the 27 notified TBE cases in the State, none reported consumption of raw goat milk or cheese from the suspected farm...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29664395/fatal-tick-borne-encephalitis-virus-infections-caused-by-siberian-and-european-subtypes-finland-2015
#18
Suvi Kuivanen, Teemu Smura, Kirsi Rantanen, Leena Kämppi, Jonas Kantonen, Mia Kero, Anu Jääskeläinen, Anne J Jääskeläinen, Jussi Sane, Liisa Myllykangas, Anders Paetau, Olli Vapalahti
In most locations except for Russia, tick-borne encephalitis is mainly caused by the European virus subtype. In 2015, fatal infections caused by European and Siberian tick-borne encephalitis virus subtypes in the same Ixodes ricinus tick focus in Finland raised concern over further spread of the Siberian subtype among widespread tick species.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29655579/hungarian-tick-borne-encephalitis-viruses-isolated-from-a-0-5-ha-focus-are-closely-related-to-finnish-strains
#19
László Egyed, Zsuzsanna Rónai, Ádám Dán
Four tick-borne encephalitis virus strains were isolated from a small 0.5-ha focus over a six-year-long period (2011-2016) in Hungary. Two strains with identical genomes were isolated from Ixodes ricinus and Haemaphysalis concinna two months apart, which shows that the virus had not evolved separately in these tick species. Whole-genome sequencing of the virus revealed that the isolates differed from each other in 4 amino acids and 9 nucleotides. The calculated substitution rates indicated that the speed of genome evolution differs from habitat to habitat, and continuously changes even within the same focus...
April 7, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29652642/powassan-virus-disease-in-the-united-states-2006-2016
#20
Elisabeth R Krow-Lucal, Nicole P Lindsey, Marc Fischer, Susan L Hills
BACKGROUND: Powassan virus (POWV) is a tick-borne flavivirus that causes rare, but often severe, disease in humans. POWV neuroinvasive disease was added to the U.S. nationally notifiable disease list in 2001 and nonneuroinvasive disease was added in 2004. The only previous review of the epidemiology of POWV disease in the United States based on cases reported to the Centers for Disease Control and Prevention (CDC) covered the period from 1999 through 2005. METHODS: We describe the epidemiology and clinical features of laboratory-confirmed POWV disease cases reported to CDC from 2006 through 2016...
March 13, 2018: Vector Borne and Zoonotic Diseases
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