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tick-borne encephalitis

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https://www.readbyqxmd.com/read/28440879/tick-borne-encephalitis-in-patients-vaccinated-against-this-disease
#1
S Lotrič-Furlan, P Bogovič, T Avšič-Županc, M Jelovšek, L Lusa, F Strle
BACKGROUND: Information on tick-borne encephalitis (TBE) in patients already vaccinated against the disease is limited. OBJECTIVES: To compare the course and outcome in patients with vaccination breakthrough TBE with findings in patients who developed TBE without previous vaccination. METHODS: All adult patients diagnosed with TBE at a single medical centre during a 16-year period and who had received at least two doses of TBE vaccine before the onset of illness qualified for the study...
April 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28432926/tick-borne-encephalitis-virus-infects-human-brain-microvascular-endothelial-cells-without-compromising-blood-brain-barrier-integrity
#2
Martin Palus, Marie Vancova, Jana Sirmarova, Jana Elsterova, Jan Perner, Daniel Ruzek
Alteration of the blood-brain barrier (BBB) is a hallmark of tick-borne encephalitis (TBE), a life-threating human viral neuroinfection. However, the mechanism of BBB breakdown during TBE, as well as TBE virus (TBEV) entry into the brain is unclear. Here, primary human microvascular endothelial cells (HBMECs) were infected with TBEV to study interactions with the BBB. Although the number of infected cells was relatively low in culture (<5%), the infection was persistent with high TBEV yields (>10(6)pfu/ml)...
April 19, 2017: Virology
https://www.readbyqxmd.com/read/28421048/functional-information-stored-in-the-conserved-structural-rna-domains-of-flavivirus-genomes
#3
REVIEW
Alba Fernández-Sanlés, Pablo Ríos-Marco, Cristina Romero-López, Alfredo Berzal-Herranz
The genus Flavivirus comprises a large number of small, positive-sense single-stranded, RNA viruses able to replicate in the cytoplasm of certain arthropod and/or vertebrate host cells. The genus, which has some 70 member species, includes a number of emerging and re-emerging pathogens responsible for outbreaks of human disease around the world, such as the West Nile, dengue, Zika, yellow fever, Japanese encephalitis, St. Louis encephalitis, and tick-borne encephalitis viruses. Like other RNA viruses, flaviviruses have a compact RNA genome that efficiently stores all the information required for the completion of the infectious cycle...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28421031/fatal-outcome-of-european-tick-borne-encephalitis-after-vaccine-failure
#4
Parham Sendi, Cédric Hirzel, Stefan Pfister, Rahel Ackermann-Gäumann, Denis Grandgirard, Ekkehard Hewer, Arto C Nirkko
Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200-250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28399176/pathological-findings-in-the-red-fox-vulpes-vulpes-stone-marten-martes-foina-and-raccoon-dog-nyctereutes-procyonoides-with-special-emphasis-on-infectious-and-zoonotic-agents-in-northern-germany
#5
Charlotte Lempp, Nicole Jungwirth, Miguel L Grilo, Anja Reckendorf, Arlena Ulrich, Abbo van Neer, Rogier Bodewes, Vanessa M Pfankuche, Christian Bauer, Albert D M E Osterhaus, Wolfgang Baumgärtner, Ursula Siebert
Anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. Hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. The present study provides a detailed characterisation of the health status of the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides) in their natural rural and peri-urban habitats in Schleswig-Holstein, Germany between November 2013 and January 2016 with focus on zoonoses and infectious diseases that are potentially threatening to other wildlife or domestic animal species...
2017: PloS One
https://www.readbyqxmd.com/read/28378977/prevalence-of-infections-and-co-infections-with-6-pathogens-in-dermacentor-reticulatus-ticks-collected-in-eastern-poland
#6
Violetta Zając, Angelina Wójcik-Fatla, Anna Sawczyn, Ewa Cisak, Jacek Sroka, Anna Kloc, Zbigniew Zając, Alicja Buczek, Jacek Dutkiewicz, Katarzyna Bartosik
Occurrence of co-infections with various pathogens in ixodid ticks creates a risk of increased severity of tick-borne diseases in humans and animals exposed to bite of the ticks carrying multiple pathogens. Accordingly, co-infections in ticks were subject of numerous analyses, but almost exclusively with regard to Ixodes ricinus complex whereas potential tick vectors belonging to other genera were much less studied. Taking into consideration the role of Dermacentor reticulatus in the transmission of various pathogens, we carried out for the first time the comprehensive statistical analysis of co-infections occurring in this tick species...
March 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28362566/impact-of-air-temperature-variation-on-the-ixodid-ticks-habitat-and-tick-borne-encephalitis-incidence-in-the-russian-arctic-the-case-of-the-komi-republic
#7
N Tokarevich, A Tronin, B Gnativ, B Revich, O Blinova, B Evengard
BACKGROUND: The causes of the recent rise of tick-borne encephalitis (TBE) incidence in Europe are discussed. Our objective was to estimate the impact of air temperature change on TBE incidence in the European part of the Russian Arctic. METHODS: We analysed the TBE incidence in the Komi Republic (RK) over a 42-year period in relation to changes in local annual average air temperature, air temperature during the season of tick activity, tick abundance, TBE-prevalence in ticks, tick-bite incidence rate, and normalised difference vegetation index within the area under study...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28361287/characteristics-of-far-eastern-strains-of-tick-borne-encephalitis-virus
#8
Galina N Leonova, Sergei I Belikov, Ilya G Kondratov
A comparative study of biological, molecular and genetic characteristics of a collection of ten strains of tick-borne encephalitis virus (TBEV) isolated in Primorsky Krai before 1960 and stored in a lyophilized state for a prolonged period (over 65 years) is presented. The collection includes the Sofjin strain isolated from the brain of a fatal case in Primorsky Krai in 1937 and transferred to the Scientific Research Institute of Epidemiology and Microbiology (Vladivostok) in 1953. All lyophilized viral strains demonstrated great preservation and high infectious activity in the model of 2-day-old non-inbred mice...
March 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28358704/prevalence-of-neurotropic-viruses-in-malignant-glioma-and-their-onco-modulatory-potential
#9
Tadej Strojnik, Darja Duh, Tamara T Lah
BACKGROUND: the association between infectious agents and tumour aetiology is relevant in about 20% of cases. PATIENTS AND METHODS: We tested high-grade glioma tissues from 45 patients for the presence of viral nucleic acids of six herpes viruses, human adenoviruses (A-G), and two neurotropic human viruses (enteroviruses, tick-borne encephalitis virus). Real-time polymerase chain reaction was used with immunolabelling. RESULTS: Three species of herpes viruses were detected: HSV-2, Epstein-Barr virus (EBV), HHV-6, and one human enterovirus...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28346868/circulation-of-zoonotic-arboviruses-in-equine-populations-of-mallorca-island-spain
#10
Jessica Vanhomwegen, Cécile Beck, Philippe Desprès, Amanda Figuerola, Ramón García, Sylvie Lecollinet, Marc López-Roig, Jean-Claude Manuguerra, Jordi Serra-Cobo
The presence of major arbovirus vector species, climate change that promotes the expansion and increase of their populations, and potential animal reservoirs mean that vector-borne diseases represent a significant health risk for Mallorca's inhabitants. Microbiological monitoring of circulating arboviruses, particularly flaviviruses causing encephalitis, was initiated using domestic horses from localities near wetlands as "sentinel" hosts. A total of 291 blood samples were taken from 172 horses between 2011 and 2012, using paired samples to highlight seroconversion events...
March 27, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28341533/epidemiology-of-infectious-encephalitis-causes-in-2016
#11
REVIEW
A Boucher, J L Herrmann, P Morand, R Buzelé, Y Crabol, J P Stahl, A Mailles
We performed a literature search in the Medline database, using the PubMed website. The incidence of presumably infectious encephalitis is estimated at 1.5-7 cases/100,000 inhabitants/year, excluding epidemics. Infectious encephalitis and immune-mediated encephalitis share similar clinical signs and symptoms. The latter accounts for a significant proportion of presumably infectious encephalitis cases without any established etiological diagnosis; as shown from a prospective cohort study where 21% of cases were due to an immune cause...
March 22, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28336423/comparative-analysis-of-complete-genome-sequences-of-european-subtype-tick-borne-encephalitis-virus-strains-isolated-from-ixodes-persulcatus-ticks-long-tailed-ground-squirrel-spermophilus-undulatus-and-human-blood-in-the-asian-part-of-russia
#12
T V Demina, S E Tkachev, I V Kozlova, E K Doroshchenko, O V Lisak, O V Suntsova, M M Verkhozina, Yu P Dzhioev, A I Paramonov, A Y Tikunov, N V Tikunova, V I Zlobin, D Ruzek
Tick-borne encephalitis virus (TBEV) is divided into three subtypes: European (TBEV-Eu), Siberian (TBEV-Sib), and Far Eastern (TBEV-FE) subtypes. The geographical range of TBEV-Eu dominates in Europe, but this subtype is present focally across the whole non-tropical forested Eurasian belt, through Russia to South Korea. However, the TBEV-Eu strains isolated outside Europe remain poorly characterized. In this study, full-genome sequences of eight TBEV-Eu isolates were determined. These strains were isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the natural foci of Western and Eastern Siberia, Russia...
March 9, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28336346/antiviral-activity-of-the-adenosine-analogue-bcx4430-against-west-nile-virus-and-tick-borne-flaviviruses
#13
Luděk Eyer, Darina Zouharová, Jana Širmarová, Martina Fojtíková, Michal Štefánik, Jan Haviernik, Radim Nencka, Erik de Clercq, Daniel Růžek
There are currently no approved antiviral therapies against medically important human flaviviruses. The imino-C-nucleoside BCX4430 shows broad-spectrum antiviral activity against a wide range of RNA viruses. Here, we demonstrate that BCX4430 inhibits tick-borne species of the genus Flavivirus; however, the antiviral effect varies against individual species. Micro-molar BCX4430 levels inhibited tick-borne encephalitis virus (TBEV); while, approximately 3-8-fold higher concentrations were needed to inhibit louping ill virus and Kyasanur Forest disease virus...
June 2017: Antiviral Research
https://www.readbyqxmd.com/read/28333618/increasing-evidence-of-tick-borne-encephalitis-tbe-virus-transmission-the-netherlands-june-2016
#14
Adriaan Cg Weststrate, Daan Knapen, Gozewijn D Laverman, Bart Schot, Jan Jw Prick, Silke A Spit, Johan Reimerink, Barry Rockx, Felix Geeraedts
We present a case of endemic tick-borne encephalitis (TBE) occurring in June 2016 in the eastern part of the Netherlands in an area where a strain of TBE virus, genetically different from the common TBE virus strains in Europe, was reported in ticks in 2016. With the start of the tick season in spring, this second autochthonous Dutch TBE case should remind physicians to consider the possibility of endemic TBE in patients with respective symptoms.
March 16, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28320144/magnetic-resonance-imaging-and-clinical-findings-in-adults-with-tick-borne-encephalitis
#15
Alexander Pichler, Johann Sellner, Gayane Harutyunyan, Astrid Sonnleitner, Daniela Sabine Klobassa, Juan-Jose Archelos-Garcia, Hannah Rock, Thomas Gattringer, Franz Fazekas
BACKGROUND: Magnetic resonance imaging (MRI) in tick-borne encephalitis (TBE) is often performed for differential diagnosis, but only a few reports on the morphologic changes in TBE patients and their relation to the disease severity exist. METHODS: We retrospectively searched for all TBE patients who were admitted to the Departments of Neurology of the Medical University of Graz (Austria) and the Paracelsus Medical University of Salzburg (Austria) between 2003 and 2014...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28268073/vaccinations-in-early-life-are-not-associated-with-development-of-islet-autoimmunity-in-type-1-diabetes-high-risk-children-results-from-prospective-cohort-data
#16
Andreas Beyerlein, Andreas N Strobl, Christiane Winkler, Michaela Carpus, Annette Knopff, Ewan Donnachie, Donna P Ankerst, Anette-G Ziegler
AIMS/HYPOTHESIS: Vaccinations in early childhood potentially stimulate the immune system and may thus be relevant for the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). We determined the association of vaccination burden with T1D-associated islet autoimmunity in children with high familial risk followed prospectively from birth. METHODS: A total of 20,570 certified vaccination records from 1918 children were correlated with time to onset of T1D-associated islet autoimmunity using Cox regression, considering multiple time periods up until age two years and vaccination types, and adjusting for HLA genotype, sex, delivery mode, season of birth, preterm delivery and maternal T1D status...
March 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28261565/borrelia-diversity-and-co-infection-with-other-tick-borne-pathogens-in-ticks
#17
Cristian Raileanu, Sara Moutailler, Ionuţ Pavel, Daniela Porea, Andrei D Mihalca, Gheorghe Savuta, Muriel Vayssier-Taussat
Identifying Borrelia burgdorferi as the causative agent of Lyme disease in 1981 was a watershed moment in understanding the major impact that tick-borne zoonoses can have on public health worldwide, particularly in Europe and the USA. The medical importance of tick-borne diseases has long since been acknowledged, yet little is known regarding the occurrence of emerging tick-borne pathogens such as Borrelia spp., Anaplasma phagocytophilum, Rickettsia spp., Bartonella spp., "Candidatus Neoehrlichia mikurensis", and tick-borne encephalitis virus in questing ticks in Romania, a gateway into Europe...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28259789/evaluation-of-a-serological-test-for-the-diagnosis-of-borrelia-miyamotoi-disease-in-europe
#18
Setareh Jahfari, Denis S Sarksyan, Nadezda M Kolyasnikova, Joppe W Hovius, Hein Sprong, Alexander E Platonov
BACKGROUND: Borrelia miyamotoi causes systemic febrile illness and is transmitted by the same tick species that transmits Borrelia burgdorferi sensu lato and tick-borne encephalitis virus. We describe a serological test using a fragment of glycerophosphodiester phosphodiesterase (GlpQ) as an antigen, and determined its performance in well-defined patient categories. METHODS: Serum of patients with PCR-confirmed Borrelia miyamotoi disease (BMD), Lyme borreliosis (LB), tick-borne encephalitis (TBE), and healthy blood donors (HBD) were collected in Udmurt Republic, Russia...
March 1, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28229397/emerging-causes-of-arbovirus-encephalitis-in-north-america-powassan-chikungunya-and-zika-viruses
#19
REVIEW
Christopher T Doughty, Sigal Yawetz, Jennifer Lyons
Arboviruses are arthropod-borne viruses transmitted by the bite of mosquitoes, ticks, or other arthropods. Arboviruses are a common and an increasing cause of human illness in North America. Powassan virus, Chikungunya virus, and Zika virus are arboviruses that have all recently emerged as increasing causes of neurologic illness. Powassan virus almost exclusively causes encephalitis, but cases are rare, sporadic, and restricted to portions of North America and Russia. Chikungunya virus has spread widely across the world, causing millions of infections...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28221100/intracellular-degradation-and-localization-of-ns1-of-tick-borne-encephalitis-virus-affect-its-protective-properties
#20
Yulia V Kuzmenko, Elizaveta S Starodubova, Anastasia S Shevtsova, Liubov L Chernokhaeva, Anastasia A Latanova, Olga V Preobrazhenskaia, Andrey V Timofeev, Galina G Karganova, Vadim L Karpov
Currently, many DNA vaccines against infectious diseases are in clinical trials; however, their efficacy needs to be improved. The potency of DNA immunogen can be optimized by targeting technologies. In the current study, to increase the efficacy of NS1 encoded by plasmid, proteasome targeting was applied. NS1 variants with or without translocation sequence and with ornithine decarboxylase as a signal of proteasomal degradation were tested for expression, localization, protein turnover, proteasomal degradation and protection properties...
January 2017: Journal of General Virology
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