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tick-borne encephalitis

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https://www.readbyqxmd.com/read/28086865/rnai-reveals-proteins-for-metabolism-and-protein-processing-associated-with-langat-virus-infection-in-ixodes-scapularis-black-legged-tick-ise6-cells
#1
Jeffrey M Grabowski, Monika Gulia-Nuss, Richard J Kuhn, Catherine A Hill
BACKGROUND: Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28077444/protein-interactions-during-the-flavivirus-and-hepacivirus-life-cycle
#2
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann
Protein-protein interactions govern biological functions in cells, in the extracellular milieu and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell. Usage of host proteins by viruses can have severe consequences e.g. apoptosis, metabolic disequilibria or altered cell proliferation and mobility. Understanding protein interactions during virus infection can thus educate us on viral infection and pathogenesis mechanisms...
January 11, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28073402/deep-sequencing-analysis-of-tick-borne-encephalitis-virus-from-questing-ticks-at-natural-foci-reveals-similarities-between-quasispecies-pools-of-the-virus
#3
Naveed Asghar, John H-O Pettersson, Patrik Dinnetz, Åshild Andreassen, Magnus Johansson
Every year, tick-borne encephalitis virus (TBEV) causes severe central nervous system infection in 10,000 to 15,000 people in Europe and Asia. TBEV is maintained in the environment by an enzootic cycle that requires a tick vector and a vertebrate host, and the adaptation of TBEV to vertebrate and invertebrate environments is essential for TBEV persistence in nature. This adaptation is facilitated by the error-prone nature of the virus' RNA-dependent RNA polymerase that generates genetically distinct virus variants called quasispecies...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28035113/serological-surveillance-of-vector-borne-and-zoonotic-diseases-among-hunters-in-eastern-poland
#4
Małgorzata Tokarska-Rodak, Dorota Plewik, Aleksander J Michalski, Marcin Kołodziej, Alicja Mełgieś, Anna Pańczuk, Henryk Konon, Marcin Niemcewicz
BACKGROUND & OBJECTIVES: Many etiological agents of zoonoses are considered as significant biological hazard to people visiting forested areas frequently, for instance, hunters. They may be exposed to ticks, rodents, and birds as well as excreta/secretions of wild animals or contaminated water and soil. Hence, this population is at risk of contracting infection with pathogens such as Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum, Babesia spp., tick-borne encephalitis virus, Bartonella spp...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28029552/epilepsia-partialis-continua-a-review
#5
REVIEW
Rūta Mameniškienė, Peter Wolf
Epilepsia partialis contina (EPC) in a narrow definition is a variant of simple focal motor status epilepticus in which frequent repetitive muscle jerks, usually arrhythmic, continue over prolonged periods of time. In a broader definition (used in this review) it also includes non-motor manifestations otherwise known as aura continua. EPC may occur as a single episode, repetitive episodes, it may be chronic progressive or non-progressive. It appears as an unusual manifestation of epilepsy in which more typical paroxysmal events are partly or entirely replaced by the sustained repetition of seizure fragments in rapid succession...
October 18, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28005032/-tick-borne-neuroinfections-clinical-characteristics-immunopathogenesis-and-new-pharmacotherapeutic-strategies
#6
A B Kon'kova-Reidman
AIM: To study the semiotics of neurological lesions in patients with tick-borne encephalitis, Ixodes tick-borne borreliosis (ITBB) and mixed infection (MI), their immunopathogenesis, and the possibilities of current pathogenetic pharmacological correction. SUBJECTS AND METHODS: A total of 220 patients with tick-borne encephalitis, ITBB, and MI concurrent with the syndromes of central nervous system lesions were examined. The immunological studies encompassed the examination of mononuclear cells in the cerebrospinal fluid (CSF), the population and subpopulation composition of lymphocytes, and nitroxidergic processes in the serum and CSF from the total level of final stable nitric oxide metabolites...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27987206/zika-virus-is-not-thermostable-very-effective-virus-inactivation-during-heat-treatment-pasteurization-of-human-serum-albumin
#7
Maria R Farcet, Thomas R Kreil
BACKGROUND: The ongoing Zika virus (ZIKV) outbreak in the Americas has also raised concerns around the potential for ZIKV transmission via blood products. Plasma-derived products are considered safe, because effective viral-inactivation and removal methods are implemented in their manufacturing processes. However, a recent study has indicated that ZIKV is "thermally stable" compared with the closely related Dengue virus, thus raising the question of whether heat treatments, as embedded in the manufacturing of plasma-derived products, are as effective against ZIKV as was previously shown for other Flaviviruses...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27982069/the-role-of-the-poly-a-tract-in-the-replication-and-virulence-of-tick-borne-encephalitis-virus
#8
Naveed Asghar, Yi-Ping Lee, Emma Nilsson, Richard Lindqvist, Wessam Melik, Andrea Kröger, Anna K Överby, Magnus Johansson
The tick-borne encephalitis virus (TBEV) is a flavivirus transmitted to humans, usually via tick bites. The virus causes tick-borne encephalitis (TBE) in humans, and symptoms range from mild flu-like symptoms to severe and long-lasting sequelae, including permanent brain damage. It has been suggested that within the population of viruses transmitted to the mammalian host, quasispecies with neurotropic properties might become dominant in the host resulting in neurological symptoms. We previously demonstrated the existence of TBEV variants with variable poly(A) tracts within a single blood-fed tick...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977689/tick-borne-diseases-in-turkey-a-review-based-on-one-health-perspective
#9
REVIEW
Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy
The importance of tick-borne diseases is increasing all over the world, including Turkey. Global warming, environmental and ecological changes and the existence of suitable habitats increase the impact of ticks and result in frequent emergence or re-emergence of tick-borne diseases (TBDs) with zoonotic characteristics. In Turkey, almost 19 TBDs have been reported in animals and men, involving four protozoa (babesiosis, theileriosis, cytauxzoonosis, hepatozoonosis), one filarial nematode (acanthocheilonemasis), ten bacterial agents (anaplasmosis, ehrlichiosis, aegyptianellosis, tick-borne typhus, Candidatus Rickettsia vini, Lyme borreliosis, tick-borne relapsing fever [TBRF], tularaemia, bartonellosis, and hemoplasmosis), and four viral infections (tick-borne encephalitis [TBE], Crimean-Congo Haemorrhagic Fever [CCHF], louping-ill [LI], and lumpy skin disease [LSD])...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27977670/serological-evidence-of-contrasted-exposure-to-arboviral-infections-between-islands-of-the-union-of-comoros-indian-ocean
#10
Koussay Dellagi, Nicolas Salez, Marianne Maquart, Sophie Larrieu, Amina Yssouf, Rahamatou Silaï, Isabelle Leparc-Goffart, Pablo Tortosa, Xavier de Lamballerie
A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27970586/mathematical-model-to-synthesize-natural-history-of-tick-borne-encephalitis-and-lyme-borreliosis-for-the-purpose-of-cost-effectiveness-analysis
#11
J Mihajlovic, J W Hovius, H Sprong, F Strle, P Bogovic, M J Postma
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27918952/evaluation-of-nf-%C3%AE%C2%BAb-concentration-in-patients-with-tick-borne-encephalitis-neuroborreliosis-anaplasmosis-and-anaplasma-phagocythophilum-with-tick-borne-encephalitis-virus-co-infection
#12
Anna Moniuszko-Malinowska, Piotr Czupryna, Justyna Dunaj, Renata Swierzbinska, Katarzyna Guziejko, Ryszard Rutkowski, Joanna Zajkowska, Sambor Grygorczuk, Maciej Kondrusik, Sławomir Pancewicz
OBJECTIVES: The aim of the study was the evaluation of NF-κB concentration in serum and cerebrospinal fluid (CSF) of patients with diagnosis of tick-borne diseases: tick-borne encephalitis (TBE), neuroborreliosis (NB), anaplasmosis (ANA) and patients co-infected with tick-borne encephalitis virus and Anaplasma phagocythophilum (TBE+ANA). Additionally NF-κB concentration during acute and convalescent period was compared. METHODS: Sixty-seven patients with diagnosis of tick-borne diseases were included in the study...
December 2, 2016: Cytokine
https://www.readbyqxmd.com/read/27884572/tick-borne-encephalitis-virus-neutralization-by-high-dose-intravenous-immunoglobulin
#13
Jana Elsterova, Martin Palus, Jana Sirmarova, Jan Kopecky, Hans Helmut Niller, Daniel Ruzek
Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing antibodies in two IVIG lots originating from the same manufacturer, and tested their ability to treat a lethal TBEV-infection in a mouse model...
November 18, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27883379/epidemiological-and-clinical-features-of-tick-borne-encephalitis-in-north-western-region-in-belarus
#14
Elena Nikolaevna Krotkova, Innesa Vladimirovna Babaeva, Michail Bogutskiy, Vladimir Maksimovich Tsyrkunov
THE PURPOSE OF THE STUDY: to present epidemiological features and clinical manifestations of TBE in patients residing in Grodno region. MATERIALS AND METHODS: A retrospective analysis of 124 case histories of patients with TBE in “Grodno Regional Infectious Clinical Hospital” in 2010 – 2014. RESULTS: Epidemiological features of tick-borne encephalitis are the prevalence of the transmission mechanism of contamination (57.3%), involvement of residents of Grodno and Grodno region (54...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27882774/usefulness-of-copeptin-as-a-potential-biomarker-in-tbe
#15
Piotr Czupryna, Anna Moniuszko-Malinowska, Adam Garkowski, Justyna Dunaj, Renata Swierzbinska, Sławomir Pancewicz, Joanna Gościk, Maciej Kondrusik, Sambor Grygorczuk, Joanna Zajkowska
OBJECTIVE: The aim of the study was to evaluate the usefulness of copeptin for differentiation of hyponatremia in the course of tick-borne encephalitis (TBE) and for being a prognostic marker of the severity of TBE. MATERIALS AND METHODS: One hundred and fourteen patients with TBE were included in the study. The control group consisted of 62 patients diagnosed with viral meningitis. RESULTS: Copeptin concentration did not differ in patients with hyponatremia and normonatremia...
December 8, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27875810/nonstructural-protein-1-of-tick-borne-encephalitis-virus-induces-oxidative-stress-and-activates-antioxidant-defense-by-the-nrf2-are-pathway
#16
Yulia V Kuzmenko, Olga A Smirnova, Alexander V Ivanov, Elizaveta S Starodubova, Vadim L Karpov
BACKGROUND: Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE: In the current study we explored the ability of TBEV nonstructural protein 1 (NS1) to induce oxidative stress and activate antioxidant defense via the nuclear factor (erythroid-derived-2)-like 2/antioxidant response element (Nrf2/ARE) pathway...
2016: Intervirology
https://www.readbyqxmd.com/read/27846275/prevalence-of-rickettsia-spp-in-ticks-and-serological-and-clinical-outcomes-in-tick-bitten-individuals-in-sweden-and-on-the-%C3%A3-land-islands
#17
Anders Lindblom, Katarina Wallménius, Johanna Sjöwall, Linda Fryland, Peter Wilhelmsson, Per-Eric Lindgren, Pia Forsberg, Kenneth Nilsson
Tick-transmitted diseases are an emerging health problem, and the hard tick Ixodes ricinus is the main vector for Borrelia spp., tick-borne encephalitis virus and most of the spotted fever Rickettsiae in Europe. The aim of the present study was to examine the incidence of rickettsial infection in the southernmost and south central parts of Sweden and the Åland Islands in Finland, the risk of infection in humans and its correlation with a bite of a Rickettsia-infected tick, the self-reported symptoms of rickettsial disease, and the prevalence of co-infection between Rickettsia spp...
2016: PloS One
https://www.readbyqxmd.com/read/27795275/complete-genome-sequence-of-a-low-virulence-tick-borne-encephalitis-virus-strain
#18
G Dobler, M Bestehorn, M Antwerpen, A Överby-Wernstedt
We report here the complete genome sequence (GenBank accession no. KX268728) of tick-borne encephalitis strain HB171/11, isolated from an Ixodes ricinus tick from a natural focus where human neurological disease is rare. The strain shows unique characteristics in neuroinvasiveness and neurovirulence.
October 20, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27779467/travel-related-tick-borne-encephalitis-israel-2006-2014
#19
Eyal Meltzer, Yael Paran, Yaniv Lustig, Shmuel Stienlauf, Miriam Weinberger, Eli Schwartz
During 2006-2014, four tick-borne encephalitis (TBE) cases occurred among Israeli travelers. We calculated TBE incidence at 321.0, 45.0, 13.2, and 7.5 cases/100,000 travelers/year of travel to Sweden, Switzerland, Austria, and Germany, respectively. TBE incidence among travelers to these destinations appears to justify TBE vaccination in accordance with World Health Organization recommendations.
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27776548/fast-type-i-interferon-response-protects-astrocytes-from-flavivirus-infection-and-virus-induced-cytopathic-effects
#20
Richard Lindqvist, Filip Mundt, Jonathan D Gilthorpe, Silke Wölfel, Nelson O Gekara, Andrea Kröger, Anna K Överby
BACKGROUND: Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined...
October 24, 2016: Journal of Neuroinflammation
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