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https://www.readbyqxmd.com/read/29228499/high-dose-intravenous-immunoglobulins-for-the-treatment-of-dermatological-autoimmune-diseases
#1
Jochen H O Hoffmann, Alexander H Enk
Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy...
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29228417/mir-155-affects-renal-carcinoma-cell-proliferation-invasion-and-apoptosis-through-regulating-gsk-3%C3%AE-%C3%AE-catenin-signaling-pathway
#2
R-J Wei, C-H Zhang, W-Z Yang
OBJECTIVE: Glycogen Synthase Kinase-3β (GSK-3β) negatively regulates Wnt/β-catenin signaling pathway through degrading β-catenin protein. It plays an inhibitory role in various tumors, while the influence in the pathogenesis of renal carcinoma has not been elucidated. MicroRNA-155 (MiR-155) was found to be upregulated in renal carcinoma tissue. Bioinformatics analysis revealed the complementary binding site between miR-155 and 3'-UTR of GSK-3β. This study investigated the influence of miR-155 in regulating GSK-3β expression, Wnt/β-catenin signaling pathway activity, and renal carcinoma cell proliferation, invasion, and apoptosis...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228392/hepatic-pharmacokinetics-and-pharmacodynamics-with-ombitasvir-paritaprevir-ritonavir-plus-dasabuvir-treatment-and-variable-ribavirin-dosage
#3
Andrew H Talal, Emily O Dumas, Barbara Bauer, Richard M Rejman, Andrew Ocque, Gene D Morse, Danijela Lucic, Gavin A Cloherty, Jennifer King, Jiuhong Zha, Hongtao Zhang, Daniel E Cohen, Nancy Shulman, Jean-Michel Pawlotsky, Christophe Hézode
Background: It is unknown whether ribavirin (RBV) co-administration modifies the early rate of decline of hepatitis C virus (HCV) RNA in the liver versus plasma compartments, specifically. Methods: This partially randomized, open-label, phase 2 study enrolled treatment-naïve, non-cirrhotic patients with HCV genotype (GT) 1a. Patients were randomized 1:1 into Arms A and B, and then enrolled in Arm C. Patients received ombitasvir/paritaprevir/ritonavir + dasabuvir for 12 weeks with either: no RBV for the first 2 weeks followed by weight-based dosing thereafter (Arm A), weight-based RBV for all 12 weeks (Arm B), or low-dose RBV (600 mg) once daily for all 12 weeks...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29228374/quantitative-trait-loci-mapping-of-western-corn-rootworm-coleoptera-chrysomelidae-host-plant-resistance-in-two-populations-of-doubled-haploid-lines-in-maize-zea-mays-l
#4
Martin O Bohn, Juan J Marroquin, Sherry Flint-Garcia, Kenton Dashiell, David B Willmot, Bruce E Hibbard
Over the last 70 yr, more than 12,000 maize accessions have been screened for their level of resistance to western corn rootworm, Diabrotica virgifera virgifera (LeConte; Coleoptera: Chrysomelidae), larval feeding. Less than 1% of this germplasm was selected for initiating recurrent selection or other breeding programs. Selected genotypes were mostly characterized by large root systems and superior root regrowth after root damage caused by western corn rootworm larvae. However, no hybrids claiming native (i...
December 8, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#5
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29228201/widespread-brain-tau-and-its-association-with-ageing-braak-stage-and-alzheimer-s-dementia
#6
Val J Lowe, Heather J Wiste, Matthew L Senjem, Stephen D Weigand, Terry M Therneau, Bradley F Boeve, Keith A Josephs, Ping Fang, Mukesh K Pandey, Melissa E Murray, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Michelle M Mielke, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Clifford R Jack
Autopsy data have proposed that a topographical pattern of tauopathy occurs in the brain with the development of dementia due to Alzheimer's disease. We evaluated the findings of tau-PET to better understand neurofibrillary tangle development as it is seen in cognitively unimpaired and impaired individuals. The evolution of Alzheimer's disease tauopathy in cognitively unimpaired individuals needs to be examined to better understand disease pathogenesis. Tau-PET was performed in 86 cognitively impaired individuals who all had abnormal amyloid levels and 601 cognitively unimpaired individuals...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29228101/spironolactone-and-resistant-hypertension-in-heart-failure-with-preserved-ejection-fraction
#7
P Rossignol, B Claggett, J Liu, O Vardeny, B Pitt, F Zannad, S Solomon
Background: Recent evidence suggests that the mineralocorticoid receptor antagonist spironolactone should be the preferred fourth line antihypertensive treatment in resistant hypertension (RHTN). Whether spironolactone improves blood pressure (BP) control in heart failure with preserved ejection fraction (HFpEF) and RHTN is unknown. Methods: We identified patients with RHTN, defined as baseline systolic blood pressure (SBP) between 140 and 160 mmHg on 3 or more medications, in the Americas cohort of the TOPCAT trial, in which patients with HFpEF were randomized to spironolactone vs...
December 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29227921/nanoparticulate-delivery-systems-for-alkyl-gallates-influence-of-the-elaboration-process-on-particle-characteristics-drug-encapsulation-and-in-vitro-release
#8
Asma Chebil, Michèle Léonard, Jean-Luc Six, Cécile Nouvel, Alain Durand
PLA nanoparticles loaded with n-alkyl gallates (AGs) were prepared either by nanoprecipitation (NP) or by O/W emulsion/solvent evaporation (E/SE). A nonionic hydrophobically modified polysaccharide was used for surface coverage and for ensuring colloidal stability. Different parameters were systematically assessed to enhance the drug incorporation, with the aim of obtaining monomodal and narrow particle size distributions. The nanoparticles were characterized by 1H NMR, transmission electron microscopy (TEM) and laser light scattering granulometry...
November 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29227749/efficacy-and-safety-of-photoselective-vaporization-of-the-prostate-with-120-w-532%C3%A2-nm-laser-in-patients-with-benign-prostatic-hyperplasia-on-anticoagulation-or-antiplatelet-therapy-observations-on-long-term-outcomes
#9
Grzegorz Piotrowicz, Tomasz Syryło, Rafał Jedynak, Henryk Zieliński
OBJECTIVE: The objective of this study was to evaluate the safety and effectiveness of photoselective vaporization of the prostate (PVP) in the treatment of patients with benign prostatic hyperplasia (BPH) on anticoagulant or antiplatelet therapy. BACKGROUND: The "gold standard" of surgical treatment of BPH is transurethral resection of the prostate (TURP). Since the risk of complications associated with TURP is still significant, there is a continuous search for safer and equally effective procedures...
December 11, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29227346/surgical-resection-of-the-primary-tumor-in-women-with-de-novo-stage-iv-breast-cancer-contemporary-practice-patterns-and-survival-analysis
#10
Whitney O Lane, Samantha M Thomas, Rachel C Blitzblau, Jennifer K Plichta, Laura H Rosenberger, Oluwadamilola M Fayanju, Terry Hyslop, E Shelley Hwang, Rachel A Greenup
OBJECTIVE: We evaluated patterns of surgical care and their association with overall survival among a contemporary cohort of women with stage IV breast cancer. BACKGROUND: Surgical resection of the primary tumor remains controversial among women with stage IV breast cancer. METHODS: Women diagnosed with clinical stage IV breast cancer from 2003 to 2012 were identified from the American College of Surgeons National Cancer Database. Those with intact primary tumors who were alive 12 months after diagnosis were categorized by treatment sequence: (1) surgery before systemic therapy, (2) systemic therapy before surgery, and (3) systemic therapy alone...
December 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29227186/diversity-of-ctx-m-extended-spectrum-%C3%AE-lactamases-in-escherichia-coli-isolates-from-retail-raw-ground-beef-first-report-of-ctx-m-24-and-ctx-m-32-in-algeria
#11
Nesrine Rebbah, Yamina Messai, Pierre Châtre, Marisa Haenni, Jean Yves Madec, Rabah Bakour
The aim of this study was to investigate the prevalence and molecular features of extended-spectrum cephalosporin resistance in Escherichia coli isolates contaminating ground beef at retail in Algeria. Of 371 ground beef samples, 27.5% were found to contain cefotaxime-resistant E. coli isolates distributed into A (24.5%), B1 (60.8%), and D (14.7%) phylogroups. A rate of 88.2% of isolates had a multidrug-resistance phenotype. All strains were producers of CTX-M type extended-spectrum β-lactamases (ESBLs): CTX-M-1, CTX-M-3, CTX-M-14, CTX-M-15, CTX-M-24, or CTX-M-32...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227107/o-w-emulsions-stabilized-by-acylglutamic-acid-alkylamine-complexes-as-noncovalent-type-double-chain-amphiphiles
#12
Toru Tojinbara, Masaaki Akamatsu, Kenichi Sakai, Hideki Sakai
We have studied the preparation and stabilization mechanism of oil-in-water (O/W) type emulsions in the presence of amphiphilic 1:1 stoichiometric complexes of acylglutamic acids (CnGlu) with tertiary alkylamines (CnDMA). Relatively stable emulsions were obtained when C16Glu-C16DMA (or C18Glu-C18DMA), hexadecane, and water were homogenized at 80 °C and then stored at room temperature. The gel-liquid crystal phase transition temperature (Tc) of C16Glu-C16DMA and C18Glu-C18DMA dispersed in water was determined to be ca...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29226999/comparison-of-outcomes-between-postpartum-and-non-postpartum-women-with-stress-urinary-incontinence-treated-with-conservative-therapy-a-prospective-cohort-study
#13
Zhi-Jing Sun, Lan Zhu, Mao-Lian Liang, Tao Xu, Jing-He Lang
AIM: This study aimed to compare the outcomes of pelvic floor muscle training (PFMT) between postpartum and non-postpartum women with stress urinary incontinence (SUI) and to detect potential factors that may influence these outcomes. METHODS: A total of 54 and 79 participants were recruited into postpartum (PP group) and non-postpartum (non-PP group) groups, respectively. A physiotherapist treated the participants twice a week for 6-8 weeks. At baseline and 6 and 12 months after treatment, the 1-h pad weight test (PWT), vaginal contraction pressure (VCP), and Incontinence Impact Questionnaire Short Form (IIQ-7) were assessed by an evaluator or physiotherapist...
December 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29226873/modeling-prion-like-processing-of%C3%A2-tau%C3%A2-protein-in-alzheimer-s-disease-for%C3%A2-pharmaceutical-development
#14
Claude M Wischik, Björn O Schelter, Damon J Wischik, John M D Storey, Charles R Harrington
 Following our discovery of a fragment from the repeat domain of tau protein as a structural constituent of the PHF-core in Alzheimer's disease (AD), we developed an assay that captured several key features of the aggregation process. Tau-tau binding through the core tau fragment could be blocked by the same diaminophenothiazines found to dissolve proteolytically stable PHFs isolated from AD brain. We found that the PHF-core tau fragment is inherently capable of auto-catalytic self-propagation in vitro, or "prion-like processing", that has now been demonstrated for several neurodegenerative disorders...
December 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29226797/axicabtagene-ciloleucel-car-t-cell-therapy-in-refractory-large-b-cell-lymphoma
#15
Sattva S Neelapu, Frederick L Locke, Nancy L Bartlett, Lazaros J Lekakis, David B Miklos, Caron A Jacobson, Ira Braunschweig, Olalekan O Oluwole, Tanya Siddiqi, Yi Lin, John M Timmerman, Patrick J Stiff, Jonathan W Friedberg, Ian W Flinn, Andre Goy, Brian T Hill, Mitchell R Smith, Abhinav Deol, Umar Farooq, Peter McSweeney, Javier Munoz, Irit Avivi, Januario E Castro, Jason R Westin, Julio C Chavez, Armin Ghobadi, Krishna V Komanduri, Ronald Levy, Eric D Jacobsen, Thomas E Witzig, Patrick Reagan, Adrian Bot, John Rossi, Lynn Navale, Yizhou Jiang, Jeff Aycock, Meg Elias, David Chang, Jeff Wiezorek, William Y Go
Background In a phase 1 trial, axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, showed efficacy in patients with refractory large B-cell lymphoma after the failure of conventional therapy. Methods In this multicenter, phase 2 trial, we enrolled 111 patients with diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, or transformed follicular lymphoma who had refractory disease despite undergoing recommended prior therapy. Patients received a target dose of 2×106 anti-CD19 CAR T cells per kilogram of body weight after receiving a conditioning regimen of low-dose cyclophosphamide and fludarabine...
December 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#16
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226555/climate-warming-is-associated-with-smaller-body-size-and-shorter-lifespans-in-moose-near-their-southern-range-limit
#17
Sarah R Hoy, Rolf O Peterson, John A Vucetich
Despite the importance of body size for individual fitness, population dynamics and community dynamics, the influence of climate change on growth and body size is inadequately understood, particularly for long-lived vertebrates. Although temporal trends in body size have been documented, it remains unclear whether these changes represent the adverse impact of climate change (environmental stress constraining phenotypes) or its mitigation (via phenotypic plasticity or evolution). Concerns have also been raised about whether climate change is indeed the causal agent of these phenotypic shifts, given the length of time-series analysed and that studies often do not evaluate - and thereby sufficiently rule out - other potential causes...
December 10, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29226493/a-prospective-study-comparing-perioperative-anxiety-and-posthospital-behavior-in-children-with-autism-spectrum-disorder-vs-typically-developing-children-undergoing-outpatient-surgery
#18
Anila B Elliott, Amy Lewandowski Holley, Alexandra C Ross, Amy O Soleta, Jeffrey L Koh
BACKGROUND: Research describing the experience of youth with autism spectrum disorders in the perioperative setting is limited. This study compared youth with autism spectrum disorder to typically developing children in the perioperative setting and examined group differences in: child anxiety, parent anxiety, premedication patterns, induction compliance, and changes in behavior postprocedure. METHODS: Participants were 60 youth (32 with autism spectrum disorder, 28 typically developing) of ages 2-19 years undergoing outpatient surgery and their parents...
December 10, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29226321/the-severity-of-periodontitis-and-metabolic-syndrome-in-korean-population-the-dong-gu-study
#19
O S Kim, M H Shin, S S Kweon, Y H Lee, O J Kim, Y J Kim, H J Chung
OBJECTIVES: We assessed the association between periodontal disease status and metabolic syndrome (MetS) and its individual components in Korean adults over 50 years old. MATERIAL AND METHODS: In the Dong-gu study, 5078 men and women aged over 50 years were included. They underwent a questionnaire survey, physical assessment, biochemical assessment and periodontal assessment. The percentages of sites with periodontal probing depth ≥4 mm, and clinical attachment loss ≥4 mm were recorded for each participant...
December 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29226292/self-assembled-uracil-complexes-containing-tautomeric-uracils-an-irmpd-spectroscopic-and-computation-study-of-the-structures-of-gaseous-uracilnca2-n-4-5-or-6-complexes
#20
Ruodi Cheng, Victoria E Rose, Barry Power, Travis D Fridgen
The structures of doubly-charged uracil (U) complexes with Ca2+, UnCa2+ (n = 4, 5, 6), were studied by infrared multiple photon dissociation (IRMPD) spectroscopy and computational methods. The ions were produced by electrospray ionization (ESI) and were isolated in the gas phase in a Fourier-transform ion cyclotron resonance mass spectrometer (FT-ICR-MS). The recorded IRMPD spectra in both the fingerprint and the C-H/N-H/O-H stretching regions, combined with computed vibrational spectra, reveal that the structures present in the greatest abundance consist of both canonical uracil as well as the lactam (or colloquially "enol") tautomer of uracil...
December 11, 2017: Physical Chemistry Chemical Physics: PCCP
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