keyword
MENU ▼
Read by QxMD icon Read
search

and o or

keyword
https://www.readbyqxmd.com/read/29684862/antioxidant-effects-of-lycium-barbarum-polysaccharides-on-photoreceptor-degeneration-in-the-light-exposed-mouse-retina
#1
Liujiu Tang, Shuyin Bao, Yu Du, Zengyan Jiang, A O Wuliji, Xiang Ren, Chenghong Zhang, Haiying Chu, Li Kong, Haiying Ma
We assessed the neuroprotective effects of Lycium barbarum Polysaccharides (LBP) on photoreceptor degeneration and the mechanisms involved in oxidative stress in light-exposed mouse retinas. Mice were given a gavage of LBP (150 mg/kg or 300 mg/kg) or phosphate buffered saline (PBS) for 7 days before exposure to light (5000 lx for 24 h). We found that LBP significantly improved the electroretinography (ERG) amplitudes of the a- and b-waves that had been attenuated by light exposure. In addition, changes caused by light exposure including photoreceptor cell loss, nuclear condensation, an increased number of mitochondria vacuoles, outer membrane disc swelling and cristae fractures were distinctly ameliorated by LBP...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684839/effects-of-sous-vide-method-at-different-temperatures-times-and-vacuum-degrees-on-the-quality-structural-and-microbiological-properties-of-pork-ham
#2
Kiyoung Jeong, Hyeonbin O, So Yeon Shin, Young-Soon Kim
This study evaluated the influence of different factors on pork hams cooked by sous-vide method. The quality and structural and microbiological properties of the treated samples were compared with those of controls. Samples were subjected to treatment at different combinations of temperature (61 °C or 71 °C), time (45 or 90 min), and vacuum degree (98.81% or 96.58%). The control sample was air packaged and boiled for 45 min in boiling water. Temperature and vacuum degree affected quality properties, while the effect of time was limited...
April 10, 2018: Meat Science
https://www.readbyqxmd.com/read/29684719/interhelical-interactions-between-d92-and-c218-in-the-cytoplasmic-domain-regulate-proton-uptake-upon-n-decay-in-the-proton-transport-of-acetabularia-rhodopsin-ii
#3
Jun Tamogami, Takashi Kikukawa, Keisuke Ohkawa, Noboru Ohsawa, Toshifumi Nara, Makoto Demura, Seiji Miyauchi, Tomomi Kimura-Someya, Mikako Shirouzu, Shigeyuki Yokoyama, Kazumi Shimono, Naoki Kamo
Acetabularia rhodopsin II (ARII or Ace2), an outward light-driven algal proton pump found in the giant unicellular marine alga Acetabularia acetabulum, has a unique property in the cytoplasmic (CP) side of its channel. The X-ray crystal structure of ARII in a dark state suggested the formation of an interhelical hydrogen bond between C218ARII and D92ARII , an internal proton donor to the Schiff base (Wada et al., 2011). In this report, we investigated the photocycles of two mutants at position C218ARII : C218AARII which disrupts the interaction with D92ARII , and C218SARII which potentially forms a stronger hydrogen bond...
April 11, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684694/microplastics-in-different-tissues-of-fish-and-prawn-from-the-musa-estuary-persian-gulf
#4
Sajjad Abbasi, Naghmeh Soltani, Behnam Keshavarzi, Farid Moore, Andrew Turner, Mina Hassanaghaei
Commercially-important species of fish and a crustacean from four sites in the Musa estuary and a site in the Persian Gulf have been analysed for the presence and location of microplastics (MPs). A total of 828 MPs were detected in the guts (gastrointestinal tracts), skin, muscle, gills and liver of demersal and pelagic fish (Platycephalus indicus, Saurida tumbil, Sillago sihama, Cynoglossus abbreviatus) from all five sites and in the exoskeleton and muscle of the tiger prawn, Penaeus semisulcatus, from three sites...
April 18, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684689/is-the-chlorophyll-derivative-zn-ii-e-6-me-a-good-photosensitizer-to-be-used-in-root-canal-disinfection
#5
P Diogo, M Mota, C Fernandes, D Sequeira, P Palma, F Caramelo, M G P M S Neves, M A F Faustino, T Gonçalves, J M Santos
BACKGROUND: The aim of this study was to assess antimicrobial efficacy and cytotoxic outcomes of a chlorophyll based photosensitizer (PS) Zn(II)chlorin e6 methyl ester (Zn(II)e6 Me), when applied to human dentin discs and root blocks infected with 48 h biofilms. The results were compared with the ones obtained with FotoSan® (commercial Toluidine Blue O formulation) and 3% sodium hypochlorite (NaOCl). METHODOLOGY: Dentin and root blocks were infected with mixed biofilms of Enterococcus faecalis and Candida albicans; exposed for 15 min to 0...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684685/the-identification-of-discontinuous-epitope-in-the-human-cystatin-c-monoclonal-antibody-hcc3-complex
#6
M Rafalik, M Spodzieja, A S Kołodziejczyk, S Rodziewicz-Motowidło, A Szymańska, A Grubb, P Czaplewska
Human cystatin C (hCC) is a cysteine proteinase inhibitor involved in pathophysiological processes of dimerization and amyloid formation. These processes are directly associated with a number of neurodegenerative disorders such as Alzheimer disease or hereditary cystatin C amyloid angiopathy (HCCAA). One of the ideas on how to prevent amyloid formation is to use immunotherapy. HCC3 is one of a group of antibodies binding to hCC and reducing the in vitro formation of cystatin C dimers. Therefore, identification of the binding sites in the hCC-HCC3 complex may facilitate a search of effective drugs against HCCAA as well as understanding the mechanisms of neurodegenerative disorders...
April 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29684602/trans-cinnamic-acid-application-for-rainbow-trout-oncorhynchus-mykiss-i-effects-on-haematological-serum-biochemical-non-specific-immune-and-head-kidney-gene-expression-responses
#7
Sevdan Yilmaz, Sebahattin Ergün
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight of 17.01 ± 0.05 g were divided into five groups, and fed daily with an additive free basal diet (control); 250, 500, 750 or 1500 mg kg-1  CA for a 60-day period. Fish were sampled every 20 days during the experiment...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684601/the-effect-of-intermittent-hypoxia-under-different-temperature-on-the-immunomodulation-in-streptococcus-agalactiae-vaccinated-nile-tilapia-oreochromis-niloticus
#8
Jing Wang, Dan-Qi Lu, Biao Jiang, Heng-Li Luo, Ge-Ling Lu, An-Xing Li
Dissolved oxygen (DO) and temperature are the potential immunomodulators in fish and play the important roles in regulating immunity. We studied the effect of intermittent hypoxia under different temperature on the immunomodulation in vaccinated Nile tilapia (Oreochromis niloticus). The expression of immune-related genes, enzymatic activities, histology, cumulative mortality, and S. agalactiae clearance were assessed. Study conditions were intermittently hypoxic (4.0 ± 1.0 mg/L DO) at 30 ± 0.5 °C or 35 ± 0...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684341/predictors-of-outcome-in-patients-with-hematologic-malignancies-admitted-to-the-intensive-care-unit
#9
Nassar Al-Zubaidi, Emad Shehada, Khaled Alshabani, Jihane ZazaDitYafawi, Pascal Kingah, Ayman O Soubani
PURPOSE: Several studies showed conflicting results about prognosis and predictors of outcome of critically ill patients with hematological malignancies (HM). The aim of this study is to determine the hospital outcome of critically ill patients with HM and the factors predicting the outcome. METHODS AND MATERIALS: All patients with HM admitted to MICU at a tertiary academic medical center were enrolled. Clinical data upon admission and during ICU stay were collected...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29684297/is-medical-marijuana-legalisation-possible-in-poland
#10
Dorota Rogowska-Szadkowska, Julia Strumiło, Sławomir Chlabicz
OBJECTIVES: In some countries of the world it is legal to use plant-based marijuana for therapeutic purposes. When we had learned that 7,000 petitioners (including doctors) signed the petition to enable access to marijuana for patients in the Czech Republic, we decided to examine the knowledge about marijuana's medical properties among Polish medical students. METHODS: Anonymous questionnaire study was conducted on a group of 181 of students of the last (sixth) year of medical school...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684249/standard-head-down-tilt-versus-modified-without-head-down-tilt-postural-drainage-in-infants-and-young-children-with-cystic-fibrosis
#11
REVIEW
Diana A Freitas, Gabriela Ss Chaves, Thayla A Santino, Cibele Td Ribeiro, Fernando Al Dias, Ricardo O Guerra, Karla Mpp Mendonça
BACKGROUND: Postural drainage is used primarily in infants with cystic fibrosis from diagnosis up to the moment when they are mature enough to actively participate in self-administered treatments. However, there is a risk of gastroesophageal reflux associated with this technique.This is an update of a review published in 2015. OBJECTIVES: To compare the effects of standard postural drainage (15º to 45º head-down tilt) with modified postural drainage (15º to 30º head-up tilt) with regard to gastroesophageal reflux in infants and young children up to six years old with cystic fibrosis in terms of safety and efficacy...
March 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#12
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#13
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684044/oxidized-phosphatidylcholines-are-produced-in-renal-ischemia-reperfusion-injury
#14
Zahra Solati, Andrea L Edel, Yue Shang, Karmin O, Amir Ravandi
BACKGROUND: The aim of this study was to determine the individual oxidized phosphatidylcholine (OxPC) molecules generated during renal ischemia/ reperfusion (I/R) injury. METHODS: Kidney ischemia was induced in male Sprague-Dawley rats by clamping the left renal pedicle for 45 min followed by reperfusion for either 6h or 24h. Kidney tissue was subjected to lipid extraction. Phospholipids and OxPC species were identified and quantitated using liquid chromatography coupled to electrospray ionization tandem mass spectrometry using internal standards...
2018: PloS One
https://www.readbyqxmd.com/read/29683976/activating-p2x7-receptors-increases-proliferation-of-human-pancreatic-cancer-cells-via-erk1-2-and-jnk
#15
Ji Hun Choi, Young Geon Ji, Jung Jae Ko, Han Jun Cho, Dong Hyeon Lee
OBJECTIVES: The aim of this study was to investigate the effects of the activated P2X7 receptors on the proliferation and growth of human pancreatic cancer cells. METHODS: Proliferation was measured by incorporating bromodeoxyuridine into pancreatic cancer cells, MIA PaCa-2 and HPAC. Expression of P2 receptors and signal molecules was examined using quantitative reverse transcription/polymerase chain reaction and/or Western blot. Proliferative effects of the P2X7 receptors in vivo were examined using a xenotransplant model of pancreatic cancer cell lines...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29683888/transfusion-rates-and-the-utility-of-type-and-screen-for-pelvic-organ-prolapse-surgery
#16
Taylor J Brueseke, Maggie F Wilkins, Marcella G Willis-Gray, Katherine E Husk, Alexis R Peedin, Elizabeth J Geller, Jennifer M Wu
OBJECTIVES: Limited data exist directly comparing the likelihood of blood transfusion by route of apical pelvic organ prolapse (POP) surgery. In addition, limited evidence is available regarding the risk of not ordering preoperative type and screen (T&S) in apical POP surgery. The objectives of the study are to (1) provide baseline data regarding the current need for preoperative T&S by comparing perioperative blood transfusion rates between 3 routes of apical POP surgery and (2) determine the rate of a positive preoperative antibody screen in women who underwent apical POP surgery...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29683851/detection-of-numerous-hiv-1-mo-recombinants-in-france
#17
Fabienne De Oliveira, Pierre Cappy, Véronique Lemée, Alice Moisan, Charlotte Pronier, Laurence Bocket, Magali Bouvier-Alias, Marie-Laure Chaix, Elyanne Gault, Odile Morvan, Jean-Dominique Poveda, Véronique Schneider, Marc Wirden, Elodie Alessandri-Gradt, Thomas Mourez, Jean-Christophe Plantier
BACKGROUND: The broad genetic divergence of HIV-1/O relative to HIV-1/M has important implications for diagnosis, monitoring and treatment. Despite this divergence, some HIV-1/M+O dual infections and HIV-1/MO recombinant forms have been reported, mostly in Cameroon, where both groups are prevalent. Here, we describe the characteristics of such infections detected in France in 10 new patients, and discuss their implications for biological and clinical practice, owing to the presence of group O species...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683818/pan-trk-immunohistochemistry-identifies-ntrk-rearrangements-in-pediatric-mesenchymal-tumors
#18
Erin R Rudzinski, Christina M Lockwood, Bradley A Stohr, Sara O Vargas, Rachel Sheridan, Jennifer O Black, Veena Rajaram, Theodore W Laetsch, Jessica L Davis
Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic nephroma. Traditionally, molecular confirmation of these fusions has included either fluorescent in situ hybridization for ETV6 rearrangements or reverse-transcriptase polymerase chain reaction for the classic ETV6-NTRK3 fusion. However, these methods overlook variant NTRK rearrangements, which are increasingly appreciated as recurrent events in a subset of pediatric mesenchymal tumors...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683392/synthetic-polymannose-as-a-drug-carrier-synthesis-toxicity-and-anti-fungal-activity-of-polymannose-amphotericin-b-conjugates
#19
Arul Prakash Francis, Sneha Gurudevan, A Jayakrishnan
Polymannose (PM) having a weight-average molar mass (Mw ) of 30-53 kDa was synthesized by the polycondensation of mannose using phosphorous acid as the catalyst and characterized by various techniques such as NMR, IR, GPC and polarimetry. 2D NMR results confirmed the presence of (1→ 6)-linked α-D-mannose residues as backbone with O-3 and O-2 substituted linear or branched chains in PM. Amphotericin B (AmB) was conjugated to periodate-oxidized PM through Schiff's linkages at 20 wt% concentration. The AmB-PM conjugates were highly soluble in phosphate buffered saline (180-250 mg/mL), exhibited negligible hemolytic potential to human erythrocytes even at a concentration of 200 μg /mL (equivalent to ~ 40 μg/mL AmB) and were non-toxic to human embryonic kidney (HEK293T) cells even at a concentration of 250 μg/mL (equivalent to ~ 50 μg/mL AmB)...
April 23, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29683327/xylylene-clips-for-the-topology-guided-control-of-the-inclusion-and-self-assembling-properties-of-cyclodextrins
#20
Tania Neva, Thais Carmona, Juan M Benito, Cédric Przybylski, Carmen Ortiz Mellet, Francisco Mendicuti, José Manuel García Fernández
The topology of β-cyclodextrin can be molded, from toroidal to ovoid basket-shaped, by the installation of an o- or m-xylylene moiety connecting two consecutive D-glucopyranosyl units through the secondary O-2(I) and O-3(II) posi-tions. This strategy can be exploited advantageously to precast the cavity for preferential inclusion of globular or planar guests as well as to privilege dimeric or monomeric species in water solution.
April 23, 2018: Journal of Organic Chemistry
keyword
keyword
116853
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"