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https://www.readbyqxmd.com/read/27923152/hydronephrosis-in-the-wnt5a-ablated-kidney-is-caused-by-an-abnormal-ureter-bladder-connection
#1
Kangsun Yun, Alan O Perantoni
The Wnt5a null mouse is a complex developmental model which, among its several posterior-localized axis defects, exhibits multiple kidney phenotypes, including duplex kidney and loss of the medullary zone. We previously reported that ablation of Wnt5a in nascent mesoderm causes duplex kidney formation as a result of aberrant development of the nephric duct and abnormal extension of intermediate mesoderm. However, these mice also display a loss of the medullary region late in gestation. We have now genetically isolated duplex kidney formation from the medullary defect by specifically targeting the progenitors for both the ureteric bud and metanephric mesenchyme...
December 3, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27922254/comparison-of-two-different-forms-of-sevoflurane-for-anaesthesia-maintenance-and-recovery
#2
Yonca Yanli, Mehtap Ozdemir, Nurten Bakan, Cafer T Yuruk, Ahmet Yildirim, Ali O Cetinkaya
BACKGROUND: Sevoflurane is a commonly used inhalation agent. There are two forms of sevoflurane in Turkey. The aim of this study was to evaluate the effects of original versus generic sevoflurane products on hemodynamics, time to reach 1 MAC level, inspired and expired sevoflurane levels and postoperative recovery profile. METHODS: Seventy patients undergoing general anaesthesia were divided into two groups as Group Sevo or Group Sojo. After intravenous induction of anaesthesia (with the same drugs in both groups), inhalation anaesthetic was started...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27922238/parental-perception-and-child-s-nutritional-status
#3
S Songül Yalçın, Esra Serdaroğlu, O Tolga İnce
Childhood obesity is a health hazard increasing worldwide. Preschool period which is under supervision of parents is a critical period to detect overweight and take precautions. We studied the factors affecting parental estimation of their preschool child's weight. Three hundred sixty seven mothers completed questionnaires consisting of child's and parents' anthropometric measurements, parents' assessment of their child's and their own weight status, and general information about their lifestyle. Mothers also chose their wish for current and future body image of their child from child drawings representing percentiles...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27922192/evidence-for-pipecolate-oxidase-in-mediating-protection-against-hydrogen-peroxide-stress
#4
Sathish Kumar Natarajan, Ezhumalai Muthukrishnan, Oleh Khalimonchuk, Justin L Mott, Donald F Becker
Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Δ(1) -piperideine-6-carboxylate (P6C) by the flavoenzyme L-pipecolate oxidase (PIPOX). P6C spontaneously hydrolyzes to generate α-aminoadipate semialdehyde, which is then converted into α-aminoadipate acid by α-aminoadipatesemialdehyde dehydrogenase. L-pipecolate was previously reported to protect mammalian cells against oxidative stress. Here, we examined whether PIPOX is involved in the mechanism of pipecolate stress protection...
December 6, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27921453/integrating-ion-mobility-spectrometry-into-mass-spectrometry-based-exposome-measurements-what-can-it-add-and-how-far-can-it-go
#5
Thomas O Metz, Erin S Baker, Emma L Schymanski, Ryan S Renslow, Dennis G Thomas, Tim J Causon, Ian K Webb, Stephan Hann, Richard D Smith, Justin G Teeguarden
Measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current MS-based analytical methods. The implementation of IMS in exposomics studies will lead to more frequent observations of previously undetected chemicals and metabolites...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921330/the-new-face-of-isotopic-nmr-at-natural-abundance
#6
Tangi Jézéquel, Valentin Joubert, Patrick Giraudeau, Gérald S Remaud, Serge Akoka
The most widely used method for isotope analysis at natural abundance is isotope ratio monitoring by Mass Spectrometry (irm-MS) which provides bulk isotopic composition in (2) H, (13) C, (15) N, (18) O or (34) S. However, in the 1980s, the direct access to Site-specific Natural Isotope Fractionation by Nuclear Magnetic Resonance (SNIF-NMR(TM) ) was immediately recognized as a powerful technique to authenticate the origin of natural or synthetic products. The initial - and still most popular - application consisted in detecting the chaptalization of wines by irm-(2) H NMR...
November 7, 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/27921293/coloniality-and-migration-are-related-to-selection-on-mhc-genes-in-birds
#7
Piotr Minias, Linda A Whittingham, Peter O Dunn
The Major Histocompatibility Complex (MHC) plays a key role in pathogen recognition as a part of vertebrate adaptive immune system. The great diversity of MHC genes in natural populations is maintained by different forms of balancing selection and its strength should correlate with the diversity of pathogens to which a population is exposed and the rate of exposure. Despite this prediction, little is known about how the life-history characteristics affect selection at the MHC. Here, we examined whether the strength of balancing selection on MHC class II genes in birds (as measured with nonsynonymous nucleotide substitutions, dN) was related to their social or migratory behaviour, two life-history characteristics correlated with pathogen exposure...
December 6, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27921275/preoperative-characteristics-of-the-p-r-o-s-t-a-t-e-scores-a-novel-predictive-tool-for-the-risk-of-positive-surgical-margin-after-radical-prostatectomy
#8
Ben Xu, Cheng Luo, Qian Zhang, Jie Jin
OBJECTIVES: To propose a novel scoring system to predict the risk of positive surgical margin (PSM) after radical prostatectomy (RP) in prostate cancer (PCa) patients. MATERIALS AND METHODS: Eight reproducible variables available from preoperative characteristics of PCa patients were measured: PSA level (P), ratio of positive biopsy needles (R), obesity (O), scores of Gleason (S), T stage by preoperative MRI scan (T), age (A), tumor volume (T) and experience of the surgeon (E)...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27921144/the-genetic-architecture-of-the-mhc-class-ii-region-in-british-texel-sheep
#9
Alsagher O A Ali, Abigail Stear, Karen Fairlie-Clarke, Gholamreza Nikbakht Brujeni, N Mahiza Md Isa, M Shahrom Bin Salisi, Katarzyna Donskow-Łysoniewska, David Groth, Johannes Buitkamp, Michael J Stear
Understanding the structure of the major histocompatibility complex, especially the number and frequency of alleles, loci and haplotypes, is crucial for efficient investigation of the way in which the MHC influences susceptibility to disease. Nematode infection is one of the most important diseases suffered by sheep, and the class II region has been repeatedly associated with differences in susceptibility and resistance to infection. Texel sheep are widely used in many different countries and are relatively resistant to infection...
December 5, 2016: Immunogenetics
https://www.readbyqxmd.com/read/27921086/ovarian-and-uterine-alterations-following-forced-swimming-an-immunohistochemical-study
#10
Seyedeh Nazanin Seyed Saadat, Fahimeh Mohammadghasemi, Hannan Ebrahimi, Hanieh Rafati Sajedi, Gelayol Chatrnour
BACKGROUND: Physical exercise is known to be a stressor stimulus that leads to reproductive disruption. OBJECTIVE: The aim of this study was to evaluate the effect of forced swimming on the uterus and ovaries in mice. MATERIALS AND METHODS: Adult mice (N=24) were divided into the following three groups: A, control; B, swimming in water (10(o)C); and C, swimming in water (23(o)C). Swimmers swam for 5 min daily for 5 consecutive days/ wk during 2 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27921074/initial-performance-studies-of-a-wearable-brain-positron-emission-tomography-camera-based-on-autonomous-thin-film-digital-geiger-avalanche-photodiode-arrays
#11
Charles R Schmidtlein, James N Turner, Michael O Thompson, Krishna C Mandal, Ida Häggström, Jiahan Zhang, John L Humm, David H Feiglin, Andrzej Krol
Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or [Formula: see text] scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27920934/crystal-structure-of-3-2-hy-droxy-eth-yl-2-methyl-sulfanyl-6-nitro-3h-benzimidazol-1-ium-chloride-monohydrate
#12
Akoun Abou, Siomenan Coulibali, Rita Kakou-Yao, T Jérémie Zoueu, A Jules Tenon
In the cation of the title hydrated molecular salt, C10H12N3O3S(+)·Cl(-)·H2O, the benzimidazolium ring system is almost planar (r.m.s. deviation = 0.006 Å) and the nitro group is inclined at an angle of 4.86 (9)° to this plane. In the crystal, C-H⋯O hydrogen bonds form centrosymmetric R2(2)(20) dimers and these are further aggregated through N-H⋯O and O-H⋯Cl hydrogen bonds involving the water mol-ecules and chloride anions. Aromatic π-π stacking inter-actions are also found between two parallel benzene rings or the benzene and imidazolium rings, with centroid-centroid distances of 3...
September 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27920899/diagnosing-clean-margins-through-raman-spectroscopy-in-human-and-animal-mammary-tumour-surgery-a-short-review
#13
REVIEW
I A Birtoiu, C Rizea, D Togoe, R M Munteanu, C Micsa, M I Rusu, M Tautan, L Braic, L O Scoicaru, A Parau, N D Becherescu-Barbu, M V Udrea, A Tonetto, R Notonier, C E A Grigorescu
Breast cancer frequency in human and other mammal female populations has worryingly increased lately. The acute necessity for taxonomy of the aetiological factors along with seeking for new diagnostic tools and therapy procedures aimed at reducing mortality have yielded in an intense research effort worldwide. Surgery is a regular method to counteract extensive development of breast cancer and prevent metastases provided that negative surgical margins are achieved. This highly technical challenge requires fast, extremely sensitive and selective discrimination between malignant and benign tissues even down to molecular level...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920790/characterization-of-resistance-mechanisms-in-faba-bean-vicia-faba-against-broomrape-species-orobanche-and-phelipanche-spp
#14
Diego Rubiales, Maria M Rojas-Molina, Josefina C Sillero
Faba bean (Vicia faba) production in Mediterranean and Near East agriculture is severely constrained by broomrape infection. The most widely distributed broomrape species affecting faba bean is Orobanche crenata, although O. foetida and Phelipanche aegyptiaca are of local importance. Only moderately resistant cultivars are available to farmers. Rizotrons studies allowed the dissection of resistance components in faba bean accessions against the very infective species O. crenata, O. foetida var. broteri and P...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27920566/hcverso1-and-2-faldaprevir-with-deleobuvir-bi-207127-and-ribavirin-for-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-c-virus-genotype-1b-infection
#15
Christoph Sarrazin, Francesco Castelli, Pietro Andreone, Maria Buti, Massimo Colombo, Stanislas Pol, Filipe Calinas, Massimo Puoti, Antonio Olveira, Mitchell Shiffman, Jerry O Stern, George Kukolj, Michael Roehrle, Stella Aslanyan, Qiqi Deng, Richard Vinisko, Federico J Mensa, David R Nelson
The interferon-free combination of once-daily faldaprevir 120 mg, twice-daily deleobuvir 600 mg, and weight-based ribavirin was evaluated in two Phase III studies (HCVerso1, HCVerso2) in hepatitis C virus genotype-1b-infected, treatment-naïve patients, including those ineligible for peginterferon (HCVerso2). Patients without cirrhosis were randomized to 16 weeks (Arm 1; n=208 HCVerso1, n=213 HCVerso2) or 24 weeks (Arm 2; n=211 in both studies) of faldaprevir + deleobuvir + ribavirin. Patients with compensated cirrhosis received open-label faldaprevir + deleobuvir + ribavirin for 24 weeks (Arm 3; n=51, n=72)...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27920331/3d-model-analysis-of-ankle-flexion-on-anatomic-reduction-of-a-syndesmotic-injury
#16
Jason M Schon, Jacob D Mikula, Jonathon D Backus, Melanie B Venderley, Grant J Dornan, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The effect of ankle positioning during suture-button fixation for syndesmosis repair on range of motion (ROM) and anatomic reduction has yet to be investigated. The purpose of this cadaveric study was to compare the effects of 3 different ankle positions during suture-button repair on volumetric reduction of the syndesmosis, fibular displacement, and ROM of the ankle using 3-dimensional computed tomography (CT) analysis. The null hypothesis was that ankle position during fixation would not affect syndesmotic volume restoration, fibular displacement, or ROM...
December 5, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27920204/studies-on-the-detection-expression-glycosylation-dimerization-and-ligand-binding-properties-of-mouse-siglec-e
#17
Shoib Siddiqui, Flavio Schwarz, Stevan Springer, Zahra Khedri, Hai Yu, Lingquan Deng, Andrea Verhagen, Yuko Naito-Matsui, Weiping Jiang, Daniel Kim, Jie Zhou, Beibei Ding, Xi Chen, Nissi Varki, Ajit Varki
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has been extensively studied, but relationships between structure and functions are poorly explored. Here we present new data relating the structure and function of Siglec-E, the major CD33-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells. We generated nine new rat monoclonal antibodies specific to mouse Siglec-E, with no cross-reactivity to Siglec-F...
December 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27920192/results-of-an-international-phosphorus-digestibility-ring-test-with-broiler-chickens
#18
M Rodehutscord, O Adeola, R Angel, P Bikker, E Delezie, W A Dozier, M Umar Faruk, M Francesch, C Kwakernaak, A Narcy, C M Nyachoti, O A Olukosi, A Preynat, B Renouf, A Saiz Del Barrio, K Schedle, W Siegert, S Steenfeldt, M M van Krimpen, S M Waititu, M Witzig
The objective of this ring test was to investigate the prececal phosphorus (P) digestibility of soybean meal (SBM) in broiler chickens using the trial protocol proposed by the World's Poultry Science Association. It was hypothesized that prececal P digestibility of SBM determined in the collaborating stations is similar. Three diets with different inclusion levels of SBM were mixed in a feed mill specialized in experimental diets and transported to 17 collaborating stations. Broiler chicks were raised on commercial starter diets according to station-specific management routine...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27919841/prevalence-of-non-adherence-to-highly-active-antiretroviral-therapy-and-its-related-clinical-and-therapeutic-factors-in-ouagadougou-burkina-faso
#19
O Guira, D S R Kaboré, G Dao, N Zagré, T M Zohoncon, V Pietra, J Simporé
: Introduction : Non-adherence to highly active antiretroviral therapy is deleterious in HIV/AIDS programs. This study contributes to the identification of its frequency and of the clinical and therapeutic factors that determine it. Material and methods : This cross-sectional study took place from December 15, 2013, to February 18, 2014, at the Saint Camille health care center and the Pietro Annigoni biomolecular research center in Ouagadougou. It includes adults who had been receiving antiretroviral therapy for at least three months and agreed to participate...
December 5, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27919735/quercetin-attenuates-high-fructose-feeding-induced-atherosclerosis-by-suppressing-inflammation-and-apoptosis-via-ros-regulated-pi3k-akt-signaling-pathway
#20
Xue-Li Lu, Cui-Hua Zhao, Xin-Liang Yao, Han Zhang
Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and onions. Previous studies have revealed its anti-inflammatory, anti-cancer, antioxidant and anti-apoptotic activities. This study investigated the ability of quercetin to inhibit high fructose feeding- or LPS-induced atherosclerosis through regulating oxidative stress, apoptosis and inflammation response in vivo and in vitro experiments. 50 and 100mg/kg quercetin were used in our study, showing significant inhibitory role in high fructose-induced atherosclerosis via reducing reactive oxygen species (ROS) levels, Caspase-3 activation, inflammatory cytokines releasing, the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL)-positive cells and collagen contents as well as modulating apoptosis- and inflammation-related proteins expression...
December 2, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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