keyword
MENU ▼
Read by QxMD icon Read
search

Francesca

keyword
https://www.readbyqxmd.com/read/29156777/patients-with-nsclc-may-display-a-low-ratio-of-p-t790m-vs-activating-egfr-mutations-in-plasma-at-disease-progression-implications-for-personalised-treatment
#1
Marzia Del Re, Paola Bordi, Iacopo Petrini, Eleonora Rofi, Francesca Mazzoni, Lorenzo Belluomini, Enrico Vasile, Giuliana Restante, Francesco Di Costanzo, Alfredo Falcone, Antonio Frassoldati, Ron H N van Schaik, Christi M J Steendam, Antonio Chella, Marcello Tiseo, Riccardo Morganti, Romano Danesi
Introduction: NSCLC harboring activating mutations of EGFR is highly sensitive to first-line EGFR-tyrosine kinase inhibitors (TKIs), but drug resistance depending on the EGFR mutation p.T790M will occur in about 50-60% of patients. Detailed information on the amount of p.T790M plasmatic level associated with resistance to EGFR-TKIs and guidance to treatment with p.T790M-effective TKI depending on these levels, is lacking. Methods: This study enrolled p.T790M-positive patients (n=49) affected by EGFR-mutated NSCLC at progression to first-line EGFR-TKIs and, in selected cases (n=5), after second-line treatment with osimertinib...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156609/green-routes-for-the-production-of-enantiopure-benzylisoquinoline-alkaloids
#2
REVIEW
Francesca Ghirga, Alessandra Bonamore, Lorenzo Calisti, Ilaria D'Acquarica, Mattia Mori, Bruno Botta, Alberto Boffi, Alberto Macone
Benzylisoquinoline alkaloids (BIAs) are among the most important plant secondary metabolites, in that they include a number of biologically active substances widely employed as pharmaceuticals. Isolation of BIAs from their natural sources is an expensive and time-consuming procedure as they accumulate in very low levels in plant. Moreover, total synthesis is challenging due to the presence of stereogenic centers. In view of these considerations, green and scalable methods for BIA synthesis using fully enzymatic approaches are getting more and more attention...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156574/infectious-agents-in-atherosclerotic-cardiovascular-diseases-through-oxidative-stress
#3
REVIEW
Marisa Di Pietro, Simone Filardo, Francesca Falasca, Ombretta Turriziani, Rosa Sessa
Accumulating evidence demonstrates that vascular oxidative stress is a critical feature of atherosclerotic process, potentially triggered by several infectious agents that are considered as risk co-factors for the atherosclerotic cardiovascular diseases (CVDs). C. pneumoniae has been shown to upregulate multiple enzymatic systems capable of producing reactive oxygen species (ROS) such as NADPH oxidase (NOX) and cyclooxygenase in vascular endothelial cells, NOX and cytochrome c oxidase in macrophages as well as nitric oxide synthase and lipoxygenase in platelets contributing to both early and late stages of atherosclerosis...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156364/pattern-recognition-of-magnetic-resonance-imaging-based-gray-matter-volume-measurements-classifies-bipolar-disorder-and-major-depressive-disorder
#4
Harry Rubin-Falcone, Francesca Zanderigo, Binod Thapa-Chhetry, Martin Lan, Jeffrey M Miller, M Elizabeth Sublette, Maria A Oquendo, David J Hellerstein, Patrick J McGrath, Johnathan W Stewart, J John Mann
BACKGROUND: Bipolar Disorder (BD) cannot be reliably distinguished from Major Depressive Disorder (MDD) until the first manic or hypomanic episode. Consequently, many patients with BD are treated with antidepressants without mood stabilizers, a strategy that is often ineffective and carries a risk of inducing a manic episode. We previously reported reduced cortical thickness in right precuneus, right caudal middle-frontal cortex and left inferior parietal cortex in BD compared with MDD...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156360/does-the-15-item-geriatric-depression-scale-function-differently-in-old-people-with-different-levels-of-cognitive-functioning
#5
Francesca Chiesi, Caterina Primi, Martina Pigliautile, Marta Baroni, Sara Ercolani, Lucia Paolacci, Virginia Boccardi, Patrizia Mecocci
BACKGROUND: The 15-item version of the Geriatric Depression Scale (GDS-15) is widely employed to screen depression among elderly but little is known about the scale functioning in cognitively impaired individuals when compared to normal ones. The aim of the current study is to investigate Differential Item Functioning (DIF) across groups of older people that differ in terms of cognitive functioning applying Item Response Theory (IRT)-based analyses. METHODS: Data from an Italian multi-centric clinical-based study on cognitive impairment and dementia in old people were employed (N = 1903; Age: M = 77...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156339/silicification-process-in-diatom-algae-using-different-silicon-chemical-sources-colloidal-silicic-acid-interactions-at-cell-surface
#6
Silvia Casabianca, Antonella Penna, Samuela Capellacci, Michela Cangiotti, Maria Francesca Ottaviani
The silicon transport and use inside cells are key processes for understanding how diatoms metabolize this element in the silica biogenic cycle in the ocean. A spin-probe electron paramagnetic resonance (EPR) study over time helped to investigate the interacting properties and the internalization mechanisms of silicic acid from different silicon sources into the cells. Diatom cells were grown in media containing biogenic amorphous substrates, such as diatomaceous earth and sponge spicules, and crystalline sodium metasilicate...
November 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29156298/european-research-on-electrochemotherapy-in-head-and-neck-cancer-eureca-project-results-from-the-treatment-of-mucosal-cancers
#7
Christina Caroline Plaschke, Giulia Bertino, James A McCaul, Juan J Grau, Remco de Bree, Gregor Sersa, Antonio Occhini, Ales Groselj, Cristobal Langdon, Derrek A Heuveling, Maja Cemazar, Primoz Strojan, C Rene Leemans, Marco Benazzo, Francesca De Terlizzi, Irene Wessel, Julie Gehl
AIM: Electrochemotherapy is an effective local treatment for cutaneous tumours and metastases. In this prospective trial, six European institutions investigated electrochemotherapy in recurrent, mucosal head and neck tumours. PATIENT AND METHODS: Forty-three patients with recurrent mucosal head and neck tumours and no further curative or reasonably effective palliative treatment options were enrolled and treated with electrochemotherapy. Patients were treated in general anaesthesia using intravenous or local injection of bleomycin followed by delivery of electric pulses to the tumour area...
November 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29155481/peroxisome-proliferator-activated-receptor-gamma-stimulation-for-prevention-of-5-fluorouracil-induced-oral-mucositis-in-mice
#8
Mariangela Sottili, Monica Mangoni, Chiara Gerini, Giulia Salvatore, Francesca Castiglione, Isacco Desideri, Pierluigi Bonomo, Icro Meattini, Daniela Greto, Mauro Loi, Giulio Francolini, Marco Perna, Roberta Grassi, Giampaolo Biti, Lorenzo Livi
BACKGROUND: Oral mucositis is a side effect of treatment regimens containing 5-fluorouracil (5-FU). The purpose of this study was to present our evaluation to see if rosiglitazone (RGZ) protected normal tissues from chemotherapy-induced oral mucositis. METHODS: C57BL/6J mice were treated with 5-FU for 5 days, with or without RGZ. Mice were euthanized after 5, 8, 11, or 15 days, and mucosal segments were collected. RESULTS: The RGZ did not affect the 5-FU-induced decrease in mouse body weight...
November 20, 2017: Head & Neck
https://www.readbyqxmd.com/read/29154924/characterization-of-three-novel-pathogenic-slc40a1-mutations-and-genotype-phenotype-correlations-in-7-italian-families-with-type-4-hereditary-hemochromatosis
#9
Silvia Majore, Maria Carmela Bonaccorsi di Patti, Michele Valiante, Fabio Polticelli, Andrea Cortese, Sabrina Di Bartolomeo, Carmelilia De Bernardo, Marianna De Muro, Fiorella Faienza, Francesca Clementina Radio, Paola Grammatico, Giovanni Musci
Mutations of SLC40A1 encoding ferroportin (Fpn), the unique cellular iron exporter, severely affect iron homeostasis causing type 4 hereditary hemochromatosis, an autosomal dominant iron overload condition with variable phenotypic manifestations. This disease can be classified as type 4A, better known as "ferroportin disease", which is due to "loss of function" mutations that lead to decreased iron export from cells, or as type 4B hemochromatosis, which is caused by "gain of function" mutations, conferring partial or complete resistance to hepcidin-mediated Fpn degradation...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29154721/validating-the-use-of-brain-volume-cutoffs-to-identify-clinically-relevant-atrophy-in-rrms
#10
Francesca Bovis, Nicola De Stefano, Joshua R Steinerman, Volker Knappertz, Maria Pia Sormani
BACKGROUND: Baseline brain volume (BV) is predictive at a group level but is difficult to interpret at the single patient level. OBJECTIVE: To validate BV cutoffs able to identify clinically relevant atrophy in relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: The expected normalized brain volume (NBV) for each patient was calculated using RRMS patients from two phase III clinical trials, applying a linear formula developed on the baseline variable of an independent data set...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29154519/current-treatments-for-anal-condylomata-acuminata
#11
Massimiliano Mistrangelo, Ivano Dal Conte, Silvio Volpatto, Giulio DI Benedetto, Valentina Testa, Francesca Currado, Mario Morino
INTRODUCTION: Condylomata acuminate are the most common sexually transmitted disease worldwide. They are usually a serious problem, but it causes emotional distress to patient and physician alike because of its marked tendency to recurrence. The presence of anogenital warts mandates treatment, also for potential degeneration of the lesions. EVIDENCE ACQUISITION: A review of the Literature has been performed to analyze proposed treatments for anogenital warts. EVIDENCE SYNTHESIS: Many treatments have been employed...
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29154484/memantine-loaded-pegylated-biodegradable-nanoparticles-for-the-treatment-of-glaucoma
#12
Elena Sánchez-López, Maria Antonia Egea, Benjamin Michael Davis, Li Guo, Marta Espina, Amelia Maria Silva, Ana Cristina Calpena, Eliana Maria Barbosa Souto, Nivedita Ravindran, Miren Ettcheto, Antonio Camins, Maria Luisa García, Maria Francesca Cordeiro
Glaucoma is a multifactorial neurodegenerative disease associated with retinal ganglion cells (RGC) loss. Increasing reports of similarities in glaucoma and other neurodegenerative conditions have led to speculation that therapies for brain neurodegenerative disorders may also have potential as glaucoma therapies. Memantine is an N-methyl-d-aspartate (NMDA) antagonist approved for Alzheimer's disease treatment. Glutamate-induced excitotoxicity is implicated in glaucoma and NMDA receptor antagonism is advocated as a potential strategy for RGC preservation...
November 20, 2017: Small
https://www.readbyqxmd.com/read/29154076/multiple-intracerebroventricular-injections-of-human-umbilical-cord-mesenchymal-stem-cells-delay-motor-neurons-loss-but-not-disease-progression-of-sod1g93a-mice
#13
Francesca Sironi, Antonio Vallarola, Martina Bruna Violatto, Laura Talamini, Mattia Freschi, Roberta De Gioia, Chiara Capelli, Azzurra Agostini, Davide Moscatelli, Massimo Tortarolo, Paolo Bigini, Martino Introna, Caterina Bendotti
Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and mesenchymal stem cells (MSCs) seem to be the most effective in ALS animal models. The umbilical cord (UC) is a source of highly proliferating fetal MSCs, more easily collectable than other MSCs. Recently we demonstrated that human (h) UC-MSCs, double labeled with fluorescent nanoparticles and Hoechst-33258 and transplanted intracerebroventricularly (ICV) into SOD1G93A transgenic mice, partially migrated into the spinal cord after a single injection...
November 10, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29153968/effect-of-contract-research-organization-bureaucracy-in-clinical-trial-management-a%C3%A2-model-from-lung-cancer
#14
Elisa Gobbini, Sara Pilotto, Giulia Pasello, Valentina Polo, Massimo Di Maio, Francesca Arizio, Domenico Galetta, Patrizia Petrillo, Rita Chiari, Roberta Matocci, Alessandro Di Costanzo, Teresa Severina Di Stefano, Massimo Aglietta, Celeste Cagnazzo, Isabella Sperduti, Emilio Bria, Silvia Novello
INTRODUCTION: Contract research organization (CRO) support is largely included in clinical trial management, although its effect in terms of time savings and benefit has not yet been quantified. We performed a retrospective multicenter analysis of lung cancer trials to explore differences in term of trial activation timelines and accrual for studies with and without CRO involvement. MATERIALS AND METHODS: Results regarding study timelines from feasibility data to first patient enrollment were collected from 7 Italian thoracic oncology departments...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29153606/pegylated-interferon-beta-in-the-treatment-of-the-theiler-s-murine-encephalomyelitis-virus-mouse-model-of-multiple-sclerosis
#15
Francesca Gilli, Darlene B Royce, Krista D DiSano, Andrew R Pachner
We evaluated the effects of pegylated-interferonβ-1a (pegIFNβ) therapy on intrathecal antibody responses, disability progression, and viral load in the CNS in mice infected with the Theiler's virus (TMEV), an animal model of progressive disability in Multiple Sclerosis (MS). The lack of a direct antiviral activity in the CNS, the absence of any effect upon the intrathecal immune response, and the failure to treat disease progression, indicate that the immunomodulatory effects of pegIFNβ-1a likely occur in the systemic circulation rather than within the CNS...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29153164/a-100-year-review-identification-and-genetic-selection-of-economically-important-traits-in-dairy-cattle
#16
Filippo Miglior, Allison Fleming, Francesca Malchiodi, Luiz F Brito, Pauline Martin, Christine F Baes
Over the past 100 yr, the range of traits considered for genetic selection in dairy cattle populations has progressed to meet the demands of both industry and society. At the turn of the 20th century, dairy farmers were interested in increasing milk production; however, a systematic strategy for selection was not available. Organized milk performance recording took shape, followed quickly by conformation scoring. Methodological advances in both genetic theory and statistics around the middle of the century, together with technological innovations in computing, paved the way for powerful multitrait analyses...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153031/human-co-culture-model-of-neurons-and-astrocytes-to-test-acute-cytotoxicity-of-neurotoxic-compounds
#17
Uliana De Simone, Francesca Caloni, Laura Gribaldo, Teresa Coccini
Alternative methods and their use in planning and conducting toxicology experiments have become essential for modern toxicologists, thus reducing or replacing living animals. Although in vitro human co-culture models allow the establishment of biologically relevant cell-cell interactions that recapitulate the tissue microenvironment and better mimic its physiology, the number of publications is limited specifically addressing this scientific area and utilizing this test method which could provide an additional valuable model in toxicological studies...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29152165/specificity-of-executive-function-and-theory-of-mind-performance-in-relation-to-attention-deficit-hyperactivity-symptoms-in-autism-spectrum-disorders
#18
Steve Lukito, Catherine R G Jones, Andrew Pickles, Gillian Baird, Francesca Happé, Tony Charman, Emily Simonoff
Background: Individuals with autism spectrum disorder (ASD) frequently demonstrate symptoms of attention-deficit/hyperactivity disorder (ADHD). Previous findings in children with ASD have suggested that these symptoms are associated with an impairment in executive function (EF) abilities. However, studies rarely considered this association within a single framework that controls for other related factors such as Theory of Mind (ToM) abilities and ASD symptoms. Methods: We used structural equation modeling to explore the relations among EF, ToM, and symptoms of ASD and ADHD, using data from a population-based sample of 100 adolescents with ASD and full-scale IQ ≥ 50 (the Special Needs and Autism Project (SNAP) cohort)...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29152138/the-hoct1-and-abcb1-polymorphisms-do-not-influence-the-pharmacodynamics-of-nilotinib-in-chronic-myeloid-leukemia
#19
Sara Galimberti, Cristina Bucelli, Elena Arrigoni, Claudia Baratè, Susanna Grassi, Federica Ricci, Francesca Guerrini, Elena Ciabatti, Carmen Fava, Antonio D'Avolio, Giulia Fontanelli, Giovanna Rege Cambrin, Alessandro Isidori, Federica Loscocco, Giovanni Caocci, Marianna Greco, Monica Bocchia, Lara Aprile, Antonella Gozzini, Barbara Scappini, Daniele Cattaneo, Anna Rita Scortechini, Giorgio La Nasa, Alberto Bosi, Pietro Leoni, Romano Danesi, Giuseppe Saglio, Giuseppe Visani, Agostino Cortelezzi, Mario Petrini, Alessandra Iurlo, Antonello Di Paolo
First-line nilotinib in chronic myeloid leukemia is more effective than imatinib to achieve early and deep molecular responses, despite poor tolerability or failure observed in one-third of patients. The toxicity and efficacy of tyrosine kinase inhibitors might depend on the activity of transmembrane transporters. However, the impact of transporters genes polymorphisms in nilotinib setting is still debated. We investigated the possible correlation between single nucleotide polymorphisms of hOCT1 (rs683369 [c...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151920/viscoelasticity-of-amyloid-plaques-in-transgenic-mouse-brain-studied-by-brillouin-microspectroscopy-and-correlative-raman-analysis
#20
Sara Mattana, Silvia Caponi, Francesco Tamagnini, Daniele Fioretto, Francesca Palombo
Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of abnormal deposits mainly composed of an aggregation-prone protein fragment, β-amyloid 1-40/1-42, into the extracellular matrix. Brillouin microspectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal acoustic waves or phonons, giving access to the viscoelasticity of a sample on a subcellular scale...
November 2017: Journal of Innovative Optical Health Sciences
keyword
keyword
116851
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"