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https://www.readbyqxmd.com/read/28927154/resistance-to-the-mtor-inhibitor-everolimus-is-reversed-by-the-downregulation-of-survivin-in-breast-cancer-cells
#1
Ludovica Taglieri, Francesca De Iuliis, Anna Giuffrida, Sabrina Giantulli, Ida Silvestri, Susanna Scarpa
Everolimus (RAD001) is an inhibitor of mammalian target of rapamycin used in combination with exemestane to treat hormone receptor-positive advanced breast cancer. However, not all patients are equally sensitive to RAD001 and certain patients develop resistance. Therefore, the present study analyzed the mechanisms involved in the resistance of breast cancer cells to RAD001 in order to identify a potential tool to overcome it. The effects of RAD001 on the inhibition of cell viability, on the induction of apoptosis and autophagy and on the regulation of survivin, an anti-apoptotic protein, were evaluated in two breast cancer cell lines: BT474 (luminal B) and MCF7 (luminal A)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926986/efficacy-of-octocog-alfa-advate-in-a-child-with-type-3-von-willebrand-disease-and-alloantibodies
#2
Gianluca Sottilotta, Francesca Luise, Elisabetta Massara, Vincenzo Oriana, Angela Piromalli
Von Willebrand disease (VWD) is the most frequent inherited bleeding disorder and is caused by either a quantitative and/or qualitative defect of the multimeric glycoprotein vonWillebrand factor (VWF).[...].
September 18, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28926559/novelties-in-evaluation-and-monitoring-of-human-immunodeficiency-virus-1-infection-is-standard-virological-suppression-enough-for-measuring-antiretroviral-treatment-success
#3
Valentina Svicher, Giulia Marchetti, Adrianna Ammassari, Francesca Ceccherini-Silberstein, Loredana Sarmati
The high potency and tolerability of the currently available antiretroviral drugs has modified HIV-1 infection from a life-threatening disease to a chronic illness. Nevertheless, some issues still remain open to optimize the management of HIV-1 infected patients in term of maintenance of virological suppression over time, identifying patients that could benefit from simplification therapy, and reducing co-mordibities driven by chronic inflammation. The availability of robust and affordable virological and immunological markers can help in solving these issues by providing information on the burden of HIV-1 reservoir in all the anatomical compartments in which the virus replicates as well as on persistent inflammation, immune activation and senescence despite successful virological suppression...
September 19, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28926464/zenker-diverticulum-in-systemic-sclerosis-related-achalasic-megaesophagus
#4
Francesca Ingegnoli, Tommaso Schioppo
No abstract text is available yet for this article.
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28926281/e-learning-to-improve-healthcare-professionals-attitudes-and-practices-on-breastfeeding
#5
Sofia Colaceci, Angela Giusti, Elise M Chapin, Maria Enrica Bettinelli, Alessia De Angelis, Francesca Zambri, Ercole Vellone, Rosaria Alvaro, Barbara De Mei
INTRODUCTION: Breastfeeding training has a crucial role in increasing healthcare professionals' attitudes and in improving professional support for breastfeeding. The collaboration between the Italian National Institute of Health, UNICEF, and the Local Health Authority of Milan has led to the development of an online course on lactation and infant feeding practices. AIM: To assess if the course was effective in improving healthcare professionals' attitudes and practices (APs)...
September 19, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28926262/effect-of-the-incorporation-of-nano-sized-titanium-dioxide-on-the-interfacial-properties-of-dppc-langmuir-monolayers
#6
Eduardo Guzmán, Eva Santini, Michele Ferrari, Libero Liggieri, Francesca Ravera
The effect of the incorporation of hydrophilic titanium dioxide (TiO2) nanoparticles on the interfacial properties of Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) has been evaluated combining interfacial thermodynamic studies, dilatational rheology and Brewster Angle Microscopy (BAM). The results show that the TiO2 nanoparticles are able to penetrate into DPPC layers, modifying the organization of the molecules and, consequently, the phase behaviour and viscoelastic properties of the systems...
September 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28926143/recurrence-of-iga-nephropathy-after-kidney-transplantation-in-steroid-continuation-versus-early-steroid-withdrawal-regimens-a-retrospective-analysis-of-the-unos-optn-database
#7
Napat Leeaphorn, Neetika Garg, Eliyahu V Khankin, Francesca Cardarelli, Martha Pavlakis
In the past 20 years, there has been an increase in use of steroid-withdrawal regimens in kidney transplantation. However, steroid withdrawal may be associated with an increased risk of recurrent IgA nephropathy (IgAN). Using UNOS/OPTN data, we analyzed adult patients with ESRD due to IgAN who received their first kidney transplant between 2000 and 2014. For the primary outcome, we used a competing risk analysis to compare the cumulative incidence of graft loss due to IgAN recurrence between early steroid-withdrawal (ESW) and steroid continuation groups...
September 19, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28926110/pacap-and-pac1r-are-differentially-expressed-in-motor-cortex-of-amyotrophic-lateral-sclerosis-patients-and-support-survival-of-ipsc-derived-motor-neurons
#8
Gabriele Bonaventura, Rosario Iemmolo, Agata Grazia D'Amico, Valentina La Cognata, Erminio Costanzo, Mario Zappia, Velia D'Agata, Francesca Luisa Conforti, Eleonora Aronica, Sebastiano Cavallaro
Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into two distinct subgroups (SALS1 and SALS2), each associated with different deregulated genes. In the present study, we focused our attention on two of them, Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its type 1 receptor (PAC1R), and validated the results of the transcriptome experiments by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), immunohistochemistry and western blot analysis...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925985/differential-effects-of-surface-functionalized-zirconium-oxide-nanoparticles-on-alveolar-macrophages-rat-lung-and-a-mouse-allergy-model
#9
Antje Vennemann, Francesca Alessandrini, Martin Wiemann
Nanoparticles (NPs) may affect the lung via their chemical composition on the surface. Here, we compared the bioactivity of zirconium oxide (ZrO₂) NPs coated with either aminopropilsilane (APTS), tetraoxidecanoic acid (TODS), polyethyleneglycol (PGA), or acrylic acid (Acryl). Supernatants from NPs-treated cultured alveolar macrophages (NR8383) tested for lactate dehydrogenase, glucuronidase, tumor necrosis factor α, and H₂O₂ formation revealed dose-dependent effects, with only gradual differences among particles whose gravitational settling and cellular uptake were similar...
September 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28925749/cardiac-telerehabilitation-a-novel-cost-efficient-care-delivery-strategy-that-can-induce-long-term-health-benefits
#10
Ines Frederix, Francesca Solmi, Massimo F Piepoli, Paul Dendale
Background Finding innovative and cost-efficient care strategies that induce long-term health benefits in cardiac patients constitutes a big challenge today. The aim of this Telerehab III follow-up study was to assess whether a 6-month additional cardiac telerehabilitation programme could induce long-term health benefits and remain cost-efficient after the tele-intervention ended. Methods and results A total of 126 cardiac patients first completed the multicentre, randomised controlled telerehabilitation trial (Telerehab III, time points t0 to t1)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28925103/autoimmune-diseases-involving-skin-and-intestinal-mucosa-are-more-frequent-in-adolescents-and-young-adults-suffering-from-atopic-dermatitis
#11
REVIEW
Francesca Cipriani, Alice Marzatico, Giampaolo Ricci
Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Our systematic review included 22 articles from PubMed describing the reciprocal association between AD and autoimmune diseases. Although not all the studies achieved statistically significant results, patients suffering from autoimmune diseases involving skin and intestinal mucosa, such as vitiligo, alopecia areata, celiac disease and inflammatory bowel diseases, showed a higher risk to have AD as comorbidity...
September 19, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28925027/a-prospective-international-study-on-adherence-to-treatment-in-305-patients-with-flaring-sle-assessment-by-drug-levels-and-by-self-administered-questionnaires
#12
Nathalie Costedoat-Chalumeau, Frédéric Houssiau, Peter Izmirly, Véronique Le Guern, Sandra Navarra, Meenakshi Jolly, Guillermo Ruiz-Irastorza, Gabriel Baron, Eric Hachulla, Nancy Agmon-Levin, Yehuda Shoenfeld, Francesca Dall'Ara, Jill Buyon, Christophe Deligny, Ricard Cervera, Estibaliz Lazaro, Holy Bezanahary, Gaëlle Leroux, Nathalie Morel, Jean-François Viallard, Christian Pineau, Lionel Galicier, Ronald Van Vollenhoven, Angela Tincani, Hanh Nguyen, Guillaume Gondran, Noel Zahr, Jacques Pouchot, Jean-Charles Piette, Michelle Petri, David Isenberg
Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by HPLC. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ<200ng/ml or undetectable desethylchloroquine), and self-administered questionnaires (MASRI<80% or MMAS-8<6). Drug levels defined 18.4% of the patients as severely nonadherent. In multivariate analyses, younger age, non-use of steroids, higher BMI and unemployment were associated with nonadherence by drug level...
September 19, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28924490/the-lauric-acid-activated-signaling-prompts-apoptosis-in-cancer-cells
#13
Rosamaria Lappano, Anna Sebastiani, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Giulia Raffaella Galli, Rosita Curcio, Roberta Malaguarnera, Antonino Belfiore, Anna Rita Cappello, Marcello Maggiolini
The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-promoting benefits of coconut oil intake, including the improvement of the quality of life in breast cancer patients during chemotherapy. As it concerns the potential to hamper tumor growth, LA was shown to elicit inhibitory effects only in colon cancer cells. Here, we provide novel insights regarding the molecular mechanisms through which LA triggers antiproliferative and pro-apoptotic effects in both breast and endometrial cancer cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28924446/use-of-intravitreal-dexamethasone-in-a-case-of-anterior-ischemic-optic-neuropathy
#14
Raffaele Nuzzi, Francesca Monteu
Nowadays there is no unique and well-established treatment for nonarteritic anterior ischemic optic neuropathy, despite being the main acute pathology that affects the optic nerve in the elderly population and often resulting in a significant loss of visual acuity. The effectiveness of oral steroids is still under debate in the international literature, although many studies show that patients treated with high doses of systemic corticosteroids have a significantly higher chance of improved visual acuity and visual fields...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28924444/implantation-of-a-multifocal-toric-intraocular-lens-after-radial-keratotomy-and-cross-linking-with-hyperopia-and-astigmatism-residues-a-case-report
#15
Raffaele Nuzzi, Francesca Monteu, Federico Tridico
Radial keratotomy is a refractive surgical technique, widely used in the 80s and early 90s to correct myopia and astigmatism, but now overcome by more recent laser techniques. Important consequences, often in patients with more than 45 years of age, are progressive hyperopic shift and/or an increase in corneal astigmatism, whose main cause seems to be an increase in the curvature radius of the central portion of the cornea. This seems to be due to radial keratotomy incisions - with the consequent need for cross-linking - intraocular pressure, and corneal biomechanical parameters...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28923831/international-comparisons-of-prevalence-awareness-and-treatment-of-pruritus-in-people-on-hemodialysis
#16
Hugh C Rayner, Maria Larkina, Mia Wang, Matthew Graham-Brown, Sabine N van der Veer, Tevfik Ecder, Takeshi Hasegawa, Werner Kleophas, Brian A Bieber, Francesca Tentori, Bruce M Robinson, Ronald L Pisoni
BACKGROUND AND OBJECTIVES: Uremic pruritus in patients on hemodialysis is associated with depression, lower quality of life, and mortality. We studied the prevalence, awareness, and treatment of pruritus to assess how well this important condition is currently managed internationally. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from 35,452 patients on hemodialysis in up to 17 countries from the Dialysis Outcomes and Practice Patterns Study were analyzed to describe pruritus prevalence from 1996 to 2015...
September 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28923306/the-flavonoid-baicalein-attenuates-cuprizone-induced-demyelination-via-suppression-of-neuroinflammation
#17
Miho Hashimoto, Shinji Yamamoto, Kensuke Iwasa, Kota Yamashina, Masaki Ishikawa, Kei Maruyama, Francesca Bosetti, Keisuke Yoshikawa
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, and axonal pathology. Baicalein isolated from the roots of Scutellaria baicalensis has been shown to exert anti-inflammatory and anti-oxidant effects. The cuprizone model is an established mouse model of MS and causes demyelination and motor dysfunction to induce neuroinflammation such as glial activation and pro-inflammatory cytokine production...
September 15, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28923001/a-molecular-view-of-the-normal-human-thyroid-structure-and-function-reconstructed-from-its-reference-transcriptome-map
#18
Lorenza Vitale, Allison Piovesan, Francesca Antonaros, Pierluigi Strippoli, Maria Chiara Pelleri, Maria Caracausi
BACKGROUND: The thyroid is the earliest endocrine structure to appear during human development, and thyroid hormones are necessary for proper organism development, in particular for the nervous system and heart, normal growth and skeletal maturation. To date a quantitative, validated transcriptional atlas of the whole normal human thyroid does not exist and the availability of a detailed expression map might be an excellent occasion to investigate the many features of the thyroid transcriptome...
September 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28922347/pearl-millet-genome-sequence-provides-a-resource-to-improve-agronomic-traits-in-arid-environments
#19
Rajeev K Varshney, Chengcheng Shi, Mahendar Thudi, Cedric Mariac, Jason Wallace, Peng Qi, He Zhang, Yusheng Zhao, Xiyin Wang, Abhishek Rathore, Rakesh K Srivastava, Annapurna Chitikineni, Guangyi Fan, Prasad Bajaj, Somashekhar Punnuri, S K Gupta, Hao Wang, Yong Jiang, Marie Couderc, Mohan A V S K Katta, Dev R Paudel, K D Mungra, Wenbin Chen, Karen R Harris-Shultz, Vanika Garg, Neetin Desai, Dadakhalandar Doddamani, Ndjido Ardo Kane, Joann A Conner, Arindam Ghatak, Palak Chaturvedi, Sabarinath Subramaniam, Om Parkash Yadav, Cécile Berthouly-Salazar, Falalou Hamidou, Jianping Wang, Xinming Liang, Jérémy Clotault, Hari D Upadhyaya, Philippe Cubry, Bénédicte Rhoné, Mame Codou Gueye, Ramanjulu Sunkar, Christian Dupuy, Francesca Sparvoli, Shifeng Cheng, R S Mahala, Bharat Singh, Rattan S Yadav, Eric Lyons, Swapan K Datta, C Tom Hash, Katrien M Devos, Edward Buckler, Jeffrey L Bennetzen, Andrew H Paterson, Peggy Ozias-Akins, Stefania Grando, Jun Wang, Trilochan Mohapatra, Wolfram Weckwerth, Jochen C Reif, Xin Liu, Yves Vigouroux, Xun Xu
Pearl millet [Cenchrus americanus (L.) Morrone] is a staple food for more than 90 million farmers in arid and semi-arid regions of sub-Saharan Africa, India and South Asia. We report the ∼1.79 Gb draft whole genome sequence of reference genotype Tift 23D2B1-P1-P5, which contains an estimated 38,579 genes. We highlight the substantial enrichment for wax biosynthesis genes, which may contribute to heat and drought tolerance in this crop. We resequenced and analyzed 994 pearl millet lines, enabling insights into population structure, genetic diversity and domestication...
September 18, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28922000/humblebragging-a-distinct-and-ineffective-self-presentation-strategy
#20
Ovul Sezer, Francesca Gino, Michael I Norton
Self-presentation is a fundamental aspect of social life, with myriad critical outcomes dependent on others' impressions. We identify and offer the first empirical investigation of a prevalent, yet understudied, self-presentation strategy: humblebragging. Across 9 studies, including a week-long diary study and a field experiment, we identify humblebragging-bragging masked by a complaint or humility-as a common, conceptually distinct, and ineffective form of self-presentation. We first document the ubiquity of humblebragging across several domains, from everyday life to social media...
September 18, 2017: Journal of Personality and Social Psychology
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