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https://www.readbyqxmd.com/read/29777435/a-woman-with-abdominal-pain-jaundice-and-elevated-ca-19-9
#1
Alessandra Fusco, Francesca Baorda, Lorenzo Porta, Alessandro A Lemos, Lucio Caccamo, Eleonora Tobaldini, Giorgio Costantino
No abstract text is available yet for this article.
May 18, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29776991/inversion-variants-in-human-and-primate-genomes
#2
Claudia Rita Catacchio, Flavia Angela Maria Maggiolini, Pietro D'Addabbo, Miriana Bitonto, Oronzo Capozzi, Martina Lepore Signorile, Mattia Miroballo, Nicoletta Archidiacono, Evan E Eichler, Mario Ventura, Francesca Antonacci
For many years, inversions have been proposed to be a direct driving force in speciation since they suppress recombination when heterozygous. Inversions are the most common large-scale differences among humans and great apes. Nevertheless, they represent large events easily distinguishable by classical cytogenetics, whose resolution, however, is limited. Here, we performed a genome-wide comparison between human, great ape, and macaque genomes using the net alignments for the most recent releases of genome assemblies...
May 18, 2018: Genome Research
https://www.readbyqxmd.com/read/29776711/preliminary-assessment-of-the-diagnostic-performances-of-a-new-rapid-diagnostic-test-for-the-serodiagnosis-of-human-cystic-echinococcosis
#3
REVIEW
Ambra Vola, Francesca Tamarozzi, Rahmah Noordin, Muhammad Hafiznur Yunus, Sam Khanbabaie, Annalisa De Silvestri, Enrico Brunetti, Mara Mariconti
Rapid diagnostic tests for cystic echinococcosis (CE) are convenient to support ultrasound diagnosis in uncertain cases, especially in resource-limited settings. We found comparable diagnostic performances of the experimental Hyd Rapid Test and the commercial VIRapid HYDATIDOSIS Test, used in our diagnostic laboratory, using samples from well-characterized hepatic CE cases.
April 14, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29776592/response-to-metals-treatment-of-fra1-a-member-of-the-ap-1-transcription-factor-family-in-p-lividus-sea-urchin-embryos
#4
Roberta Russo, Rosa Bonaventura, Marco Chiaramonte, Caterina Costa, Valeria Matranga, Francesca Zito
Lithium (Li), Nickel (Ni), and Zinc (Zn) are metals normally present in the seawater, although they can have adverse effects on the marine ecosystem at high concentrations by interfering with many biological processes. These metals are toxic for sea urchin embryos, affecting their morphology and developmental pathways. In particular, they perturb differently the correct organization of the embryonic axes (animal-vegetal, dorso-ventral): Li is a vegetalizing agent and Ni disrupts the dorso-ventral axis, while Zn has an animalizing effect...
May 5, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29774726/single-lung-ventilation-associated-to-ecmo-an-alternative-approach-to-manage-ventilator-induced-lung-injuries-in-infants
#5
Matteo Di Nardo, Joseph Nunziata, Francesca Stoppa, Margherita Lonero, Daniela Perrotta, Corrado Cecchetti, Salvatore Grasso
No abstract text is available yet for this article.
May 15, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29774715/-health-surveillance-programme-for-workers-with-past-asbestos-exposure-in-tuscany-region-central-italy
#6
Elisabetta Chellini, Francesca Battisti, Maura Pellegri, Maurizio Baldacci, Domenico Sallese, Alfonso Cristaudo, Pietro Sartorelli, Giulio Arcangeli, Massimo Paoli, Sandra Fani, Gianluca Festa, Piergiuseppe Calà
Asbestos-related diseases are characterized by a long latency time since exposure. This accounts for a health surveillance programme addressed to asbestos workers to be performed for decades after the cessation of occupational exposure. We describe the health surveillance programme for former asbestos-exposed workers in Tuscany Region (Central Italy), with particular attention to organization and related critical issues. The Deliberation of the Regional Administration of Tuscany (No. 396/2016) supports the programme, defined by a regional group of experts, and defines the public health services where the programme has to be implemented...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29773792/mxb-is-an-interferon-induced-restriction-factor-of-human-herpesviruses
#7
Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F Greber, Jovan Pavlovic
The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV)...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773701/accuracy-of-lung-cancer-icd-9-cm-codes-in-umbria-napoli-3-sud-and-friuli-venezia-giulia-administrative-healthcare-databases-a-diagnostic-accuracy-study
#8
Alessandro Montedori, Ettore Bidoli, Diego Serraino, Mario Fusco, Gianni Giovannini, Paola Casucci, David Franchini, Annalisa Granata, Valerio Ciullo, Maria Francesca Vitale, Michele Gobbato, Rita Chiari, Francesco Cozzolino, Massimiliano Orso, Walter Orlandi, Iosief Abraha
OBJECTIVES: To assess the accuracy of International Classification of Diseases 9th Revision-Clinical Modification (ICD-9-CM) codes in identifying subjects with lung cancer. DESIGN: A cross-sectional diagnostic accuracy study comparing ICD-9-CM 162.x code (index test) in primary position with medical chart (reference standard). Case ascertainment was based on the presence of a primary nodular lesion in the lung and cytological or histological documentation of cancer from a primary or metastatic site...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773666/ancient-genomes-document-multiple-waves-of-migration-in-southeast-asian-prehistory
#9
Mark Lipson, Olivia Cheronet, Swapan Mallick, Nadin Rohland, Marc Oxenham, Michael Pietrusewsky, Thomas Oliver Pryce, Anna Willis, Hirofumi Matsumura, Hallie Buckley, Kate Domett, Nguyen Giang Hai, Trinh Hoang Hiep, Aung Aung Kyaw, Tin Tin Win, Baptiste Pradier, Nasreen Broomandkhoshbacht, Francesca Candilio, Piya Changmai, Daniel Fernandes, Matthew Ferry, Beatriz Gamarra, Eadaoin Harney, Jatupol Kampuansai, Wibhu Kutanan, Megan Michel, Mario Novak, Jonas Oppenheimer, Kendra Sirak, Kristin Stewardson, Zhao Zhang, Pavel Flegontov, Ron Pinhasi, David Reich
Southeast Asia is home to rich human genetic and linguistic diversity, but the details of past population movements in the region are not well known. Here, we report genome-wide ancient DNA data from eighteen Southeast Asian individuals spanning from the Neolithic period through the Iron Age (4100-1700 years ago). Early farmers from Man Bac in Vietnam exhibit a mixture of East Asian (southern Chinese agriculturalist) and deeply diverged eastern Eurasian (hunter-gatherer) ancestry characteristic of Austroasiatic speakers, with similar ancestry as far south as Indonesia providing evidence for an expansive initial spread of Austroasiatic languages...
May 17, 2018: Science
https://www.readbyqxmd.com/read/29773414/hypofractionated-whole-breast-irradiation-with-or-without-boost-in-elderly-patients-clinical-evaluation-of-an-italian-experience
#10
Maria Carmen De Santis, Francesca Bonfantini, Francesca Di Salvo, Alba Fiorentino, Michela Dispinzieri, Mariangela Caputo, Serena Di Cosimo, Gabriella Mariani, Massimiliano Gennaro, Vito Cosentino, Milena Sant, Emanuele Pignoli, Riccardo Valdagni, Laura Lozza
PURPOSE: To examine local control, disease-free survival (DFS), and toxicity in elderly (≥ 65 years) breast cancer patients treated with hypofractionated radiotherapy (hypo-RT) with or without a boost to the tumor bed. PATIENTS AND METHODS: The study was conducted on 752 patients treated from April 2009 to February 2017. Patients received 42.4 Gy in 16 daily fractions (2.65 Gy per fraction). A boost was only administered in cases of grade 3 primary tumor and close or positive margins...
April 22, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29773378/nanostructured-starch-combined-with-hydroxytyrosol-in-poly-vinyl-alcohol-based-ternary-films-as-active-packaging-system
#11
Francesca Luzi, Elena Fortunati, Alessandro Di Michele, Elisa Pannucci, Ermelinda Botticella, Luca Santi, José Maria Kenny, Luigi Torre, Roberta Bernini
Novel ternary films have been realized by using poly(vinyl alcohol) (PVA) as polymeric matrix, nanostructured starch as reinforcement phase and hydroxytyrosol (HTyr), a low-molecular phenolic compound present in olive oil, as antioxidant agent. Nanostructured starch, in the form of starch nanocrystals (NC) and nanoparticles (NP) obtained by acid hydrolysis and ultrasound irradiation of starch derived from the bread wheat variety Cadenza (WT, amylose content 33%) and a derived-high amylose line (HA, amylose content 75%), was considered...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773318/nickel-toxicity-in-p-lividus-embryos-dose-dependent-effects-and-gene-expression-analysis
#12
Rosa Bonaventura, Francesca Zito, Marco Chiaramonte, Caterina Costa, Roberta Russo
Many industrial activities release Nickel (Ni) in the environment with harmful effects for terrestrial and marine organisms. Despite many studies on the mechanisms of Ni toxicity are available, the understanding about its toxic effects on marine organisms is more limited. We used Paracentrotus lividus as a model to analyze the effects on the stress pathways in embryos continuously exposed to different Ni doses, ranging from 0.03 to 0.5 mM. We deeply examined the altered embryonic morphologies at 24 and 48 h after Ni exposure...
May 4, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29773243/impact-of-diabetes-and-increasing-body-mass-index-category-on-left-ventricular-systolic-and-diastolic-function
#13
Arnold C T Ng, Francesca Prevedello, Giulia Dolci, Cornelis J Roos, Roxana Djaberi, Matteo Bertini, See Hooi Ewe, Christine Allman, Dominic Y Leung, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
BACKGROUND: Diabetes and obesity are both worldwide growing epidemics, and both are independently associated with increased risk for heart failure and death. The aim of this study was to examine the additive detrimental effect of both diabetes and increasing body mass index (BMI) category on left ventricular (LV) myocardial systolic and diastolic function. METHODS: The present retrospective multicenter study included 653 patients (337 with type 2 diabetes and 316 without diabetes) of increasing BMI category...
May 15, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29772549/long-non-coding-rna-and-polycomb-an-intricate-partnership-in-cancer-biology
#14
Cyrinne Achour, Francesca Aguilo
High-throughput analyses have revealed that the vast majority of the transcriptome does not code for proteins. These non-translated transcripts, when larger than 200 nucleotides, are termed long non-coding RNAs (lncRNAs), and play fundamental roles in diverse cellular processes. LncRNAs are subject to dynamic chemical modification, adding another layer of complexity to our understanding of the potential roles that lncRNAs play in health and disease. Many lncRNAs regulate transcriptional programs by influencing the epigenetic state through direct interactions with chromatin-modifying proteins...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29772346/tackling-bioactive-glass-excessive-in-vitro-bioreactivity-preconditioning-approaches-for-cell-culture-tests
#15
REVIEW
Francesca E Ciraldo, Elena Boccardi, Virginia Melli, Fabian Westhauser, Aldo R Boccaccini
Bioactive glasses (BGs) are being increasingly considered for biomedical applications in bone and soft tissue replacement approaches thanks to their ability to form strong bonding with tissues. However, due to their high reactivity once in contact with water-based solutions BGs rapidly exchange ions with the surrounding environment leading in most cases to an undesired increase of the pH under static in vitro conditions (due to alkaline ion "burst release"), making difficult or even impossible to perform cell culture studies...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772314/urgent-use-of-gore-excluder-iliac-branch-endoprosthesis-ibe-with-left-transaxillary-approach-for-preservation-of-the-residual-hypogastric-artery-a-case-series
#16
D'Oria Mario, Chiarandini Stefano, Pipitone Marco, Calvagna Cristiano, Riccitelli Francesco, Rotelli Alice, Zamolo Francesca, Griselli Filippo
Preservation of the residual hypogastric artery (HGA) in patients with previous endovascular aortic aneurysm repair (EVAR) may require complex operative strategies. We report an alternative technique to preserve the residual HGA with the Gore Excluder Iliac Branch endoprosthesis (IBE) in urgent situations. MethodsWe report the case of two high-risk patients (unfit for open surgery), with previous EVAR and exclusion of one HGA, treated in emergency setting. Both patients met the anatomical requirements for Gore IBE use...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772310/recombination-activity-of-human-rag2-mutations-and-correlation-with-the-clinical-phenotype
#17
Irit Tirosh, Yasuhiro Yamazaki, Francesco Frugoni, Francesca A Ververs, Eric J Allenspach, Yu Zhang, Siobhan Burns, Waleed Al-Herz, Lenora Noroski, Jolan E Walter, Andrew R Gennery, Mirjam van der Burg, Luigi D Notarangelo, Yu Nee Lee
BACKGROUND: Mutations in the Recombinase Activating Gene 1 and 2 (RAG1, RAG2) are associated with a broad range of clinical and immunological phenotypes in humans. OBJECTIVE: Using a flow cytometry-based assay, we aimed to measure the recombinase activity of naturally occurring RAG2 mutant proteins, and to correlate results with the severity of the clinical and immunological phenotype. METHODS: Abelson virus-transformed Rag2-/- pro-B cells engineered to contain an inverted GFP cassette flanked by recombination signal sequences (RSS) were transduced with retroviruses encoding either wild-type or 41 naturally occurring RAG2 variants...
May 14, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29771982/idiosyncratic-representation-of-peripersonal-space-depends-on-the-success-of-one-s-own-motor-actions-but-also-the-successful-actions-of-others
#18
Yann Coello, François Quesque, Maria-Francesca Gigliotti, Laurent Ott, Jean-Luc Bruyelle
Peripersonal space is a multisensory representation of the environment around the body in relation to the motor system, underlying the interactions with the physical and social world. Although changing body properties and social context have been shown to alter the functional processing of space, little is known about how changing the value of objects influences the representation of peripersonal space. In two experiments, we tested the effect of modifying the spatial distribution of reward-yielding targets on manual reaching actions and peripersonal space representation...
2018: PloS One
https://www.readbyqxmd.com/read/29771567/enacting-rituals-to-improve-self-control
#19
Allen Ding Tian, Juliana Schroeder, Gerald Häubl, Jane L Risen, Michael I Norton, Francesca Gino
Rituals are predefined sequences of actions characterized by rigidity and repetition. We propose that enacting ritualized actions can enhance subjective feelings of self-discipline, such that rituals can be harnessed to improve behavioral self-control. We test this hypothesis in 6 experiments. A field experiment showed that engaging in a pre-eating ritual over a 5-day period helped participants reduce calorie intake (Experiment 1). Pairing a ritual with healthy eating behavior increased the likelihood of choosing healthy food in a subsequent decision (Experiment 2), and enacting a ritual before a food choice (i...
June 2018: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29771251/-ebm-guidelines-protocols-knowledge-attitudes-and-utilization-in-the-era-of-law-on-professional-responsibility-and-safety-of-health-care
#20
Silvia Minozzi, Francesca Ruggiero, Matteo Capobussi, Marien González-Lorenzo, Micaela La Regina, Alessandro Squizzato, Lorenzo Moja, Francesco Orlandini
INTRODUCTION: <AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The knowledge of principles and methods of Evidence Based Medicine (EBM) and the use of Clinical Practice Guidelines to inform clinical decisions are recognised as key instruments to improve the quality of care. In Italy the Parliament has revised the legal system that rules the responsibilities of health professionals and health care safety, prescribing health professionals to adhere to guidelines and good practice recommendations...
May 2018: Recenti Progressi in Medicina
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