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https://www.readbyqxmd.com/read/29353081/hydrogels-based-on-poly-methyl-vinyl-ether-co-maleic-acid-and-tween-85-for-sustained-delivery-of-hydrophobic-drugs
#1
Eneko Larrañeta, Laura Barturen, Michael Ervine, Ryan F Donnelly
Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 were prepared for hydrophobic drug delivery. The hydrogels were synthesized following a simple procedure carried out in solid state. The process did not require the use of any solvent and, as it is based on an esterification reaction, no toxic by-products were obtained. The resulting hydrogels contained Tween 85 inside the structure and due to the amphiphilic nature of this compound, hydrophobic domains within the hydrogel structure were formed...
January 15, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29351325/impact-of-educational-interventions-on-adolescent-attitudes-and-knowledge-regarding-vaccination-a-pilot-study
#2
Kate Carolan, Joanna Verran, Matthew Crossley, James Redfern, Nicola Whitton, Martyn Amos
BACKGROUND: Current immunisation levels in England currently fall slightly below the threshold recommended by the World Health Organization, and the three-year trend for vaccination uptake is downwards. Attitudes towards vaccination can affect future decisions on whether or not to vaccinate, and this can have significant public health implications. Interventions can impact future vaccination decisions, and these interventions can take several forms. Relatively little work has been reported on the use of vaccination interventions in young people, who form the next generation of individuals likely to make vaccination decisions...
2018: PloS One
https://www.readbyqxmd.com/read/29351255/game-theoretical-design-of-an-adaptive-distributed-dissemination-protocol-for-vanets
#3
Cristhian Iza-Paredes, Ahmad Mohamad Mezher, Mónica Aguilar Igartua, Jordi Forné
Road safety applications envisaged for Vehicular Ad Hoc Networks (VANETs) depend largely on the dissemination of warning messages to deliver information to concerned vehicles. The intended applications, as well as some inherent VANET characteristics, make data dissemination an essential service and a challenging task in this kind of networks. This work lays out a decentralized stochastic solution for the data dissemination problem through two game-theoretical mechanisms. Given the non-stationarity induced by a highly dynamic topology, diverse network densities, and intermittent connectivity, a solution for the formulated game requires an adaptive procedure able to exploit the environment changes...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29350533/development-of-pickering-emulsions-stabilized-by-gliadin-proanthocyanidins-hybrid-particles-gphps-and-the-fate-of-lipid-oxidation-and-digestion
#4
Fu-Zhen Zhou, Li Yan, Shou-Wei Yin, Chuan-He Tang, Xiao-Quan Yang
This work attempted to engineer emulsions' interface using special affinity between proline-rich gliadin and proanthocyanidins (PA), to develop surfactant-free antioxidant Pickering emulsions with digestive-resistant properties. This binding interaction between gliadin and PA benefited the interfacial adsorption of the particles to corn oil droplets. Pickering droplets as building units assembled into interconnected three-dimensional network structure, giving the emulsions viscoelasticity and ultra-stability...
January 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29343959/antitumor-effect-of-a-new-nano-vector-with-mirna-135a-on-malignant-glioma
#5
Chaofeng Liang, Weitong Sun, Haiyong He, Baoyu Zhang, Cong Ling, Bocheng Wang, Tengchao Huang, Bo Hou, Ying Guo
Introduction: MiR-135a is found to selectively induce apoptosis in glioma cell but not in normal neurons and glial cells. However, low transfection efficacy limits its application in vivo as other miRNAs. We prepared a new kind of nano-vector based on polyethylene glycol methyl ether (mPEG) and hyper-branched polyethylenimine (hy-PEI) in order to improve the miRNA delivery system into the glioma cells. Methods: The mPEG-g-PEI/miR-135a was constructed and detected by 1H NMR and FTIR analyses...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29343190/factors-affecting-effective-ventilation-during-newborn-resuscitation-a-qualitative-study-among-midwives-in-rural-tanzania
#6
R Moshiro, H L Ersdal, P Mdoe, H L Kidanto, C Mbekenga
BACKGROUND: Intrapartum-related hypoxia accounts for 30% of neonatal deaths in Tanzania. This has led to the introduction and scaling-up of the Helping Babies Breathe (HBB) programme, which is a simulation-based learning programme in newborn resuscitation skills. Studies have documented ineffective ventilation of non-breathing newborns and the inability to follow the HBB algorithm among providers. OBJECTIVE: This study aimed at exploring barriers and facilitators to effective bag mask ventilation, an essential component of the HBB algorithm, during actual newborn resuscitation in rural Tanzania...
2018: Global Health Action
https://www.readbyqxmd.com/read/29341340/bias-from-restricting-to-live-births-when-estimating-effects-of-prescription-drug-use-on-pregnancy-complications-a-simulation
#7
Elizabeth A Suarez, Suzanne N Landi, Mitchell C Conover, Michele Jonsson Funk
PURPOSE: Administrative claim databases are increasingly being used to study the safety of medication exposures during pregnancy. These studies are restricted to live births due to a reliance on algorithms for estimating gestational age that are based on codes associated with live delivery. Conditioning on live birth may induce selection bias when studying the effect of a drug on a pregnancy complication if fetal death is a competing risk for the complication or is caused by the complication...
January 17, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29339580/advantages-of-soft-subdural-implants-for-the-delivery-of-electrochemical-neuromodulation-therapies-to-the-spinal-cord
#8
Marco Capogrosso, Jérôme Gandar, Nathan Greiner, Eduardo Martin Moraud, Nikolaus Wenger, Polina Shkorbatova, Pavel E Мusienko, Ivan Minev, Stephanie P Lacour, Gregoire Courtine
We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or above the dura mater. Theoretically, the subdural location combines many advantages, including increased selectivity of electrical stimulation, lower stimulation thresholds, and targeted chemical stimulation through local drug delivery. However, these advantages have not been documented, nor have their functional impact been studied in-silico or in a relevant animal model of neurological disorders using a multimodal neural interface...
January 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29338852/simulation-based-multidisciplinary-team-training-decreases-time-to-critical-operations-for-trauma-patients
#9
Margaret Murphy, Kate Curtis, Mary K Lam, Cameron S Palmer, Jeremy Hsu, Andrea McCloughen
BACKGROUND: Simulation has been promoted as a platform for training trauma teams. However, it is not clear if this training has an impact on health service delivery and patient outcomes. This study evaluates the association between implementation of a simulation based multidisciplinary trauma team training program at a metropolitan trauma centre and subsequent patient outcomes. METHOD: This was a retrospective review of trauma registry data collected at an 850-bed Level 1 Adult Trauma Centre in Sydney, Australia...
January 8, 2018: Injury
https://www.readbyqxmd.com/read/29337911/throughput-analysis-on-3-dimensional-underwater-acoustic-network-with-one-hop-mobile-relay
#10
Xuefeng Zhong, Fangjiong Chen, Jiasheng Fan, Quansheng Guan, Fei Ji, Hua Yu
Underwater acoustic communication network (UACN) has been considered as an essential infrastructure for ocean exploitation. Performance analysis of UACN is important in underwater acoustic network deployment and management. In this paper, we analyze the network throughput of three-dimensional randomly deployed transmitter-receiver pairs. Due to the long delay of acoustic channels, complicated networking protocols with heavy signaling overhead may not be appropriate. In this paper, we consider only one-hop or two-hop transmission, to save the signaling cost...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29337286/estimation-of-parameters-for-plasma-glucose-regulation-in-type-2-diabetics-in-presence-of-meal
#11
Prova Biswas, Ashoke Sutradhar, Pallab Datta
In this study, the authors propose a methodology for the estimation of glucose masses in stomach (both in solid and liquid forms), intestine, plasma and tissue; insulin masses in portal vein, liver, plasma and interstitial fluid using only plasma glucose measurement. The proposed methodology fuses glucose-insulin homoeostasis model (in the presence of meal intake) and plasma glucose measurement with a Bayesian non-linear filter. Uncertainty of the model over individual variations has been incorporated by adding process noise to the homoeostasis model...
February 2018: IET Systems Biology
https://www.readbyqxmd.com/read/29337099/facile-preparation-and-characterization-of-ph-sensitive-mt-cmc-nanocomposite-hydrogel-beads-for-propranolol-controlled-release
#12
Hassan Farhadnejad, Seyed Alireza Mortazavi, Mohammad Erfan, Behzad Darbasizadeh, Hamidreza Motasadizadeh, Yousef Fatahi
The main aim of the present study was to design pH-sensitive nanocomposite hydrogel beads, based on carboxymethyl cellulose (CMC) and montmorillonite (Mt)-propranolol (PPN) nanohybrid, and evaluate whether the prepared nanocomposite beads could potentially be used as oral drug delivery systems. PPN-as a model drug-was intercalated into the interlayer space of Mt clay mineral via the ion exchange procedure. The resultant nanohybrid (Mt-PPN) was applied to fabricate nanocomposite hydrogel beads by association with carboxymethyl cellulose...
January 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29337095/development-of-native-and-modified-banana-starch-nanoparticles-as-vehicles-for-curcumin
#13
Leonardo Acevedo-Guevara, Leonardo Nieto-Suaza, Leidy T Sanchez, Magda I Pinzon, Cristian C Villa
In recent years, starch nanoparticles have been of great interest for drug delivery due to their relatively easy synthesis, biocompatibility, and vast amount of botanical sources. Native and acetylated starch obtained from green bananas were used for synthesis of curcumin-loaded starch nanoparticles. Mean particle size, encapsulation efficiency, and curcumin release in simulated gastric and intestinal fluids were studied. Both nanosystems showed sizes lower than 250 nm and encapsulation efficiency above 80%, with acetylated banana starch nanoparticles having the capacity to encapsulate more curcumin molecules...
January 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29333203/biomimetic-microfluidic-platform-for-the-quantification-of-transient-endothelial-monolayer-permeability-and-therapeutic-transport-under-mimicked-cancerous-conditions
#14
Christopher George Uhl, Vladimir R Muzykantov, Yaling Liu
Therapeutic delivery from microvasculature to cancerous sites is influenced by many factors including endothelial permeability, vascular flow rates/pressures, cancer secretion of cytokines and permeabilizing agents, and characteristics of the chosen therapeutics. This work uses bi-layer microfluidics capable of studying dye and therapeutic transport from a simulated vessel to a cancerous region while allowing for direct visualization and quantification of endothelial permeability. 2.5 to 13 times greater dye transport was observed when utilizing small dye sizes (FITC) when compared to larger molecules (FITC-Dextran 4 kDa and FITC-Dextran 70 kDa), respectively...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29332497/dosimetric-analysis-of-microscopic-disease-in-sbrt-for-lung-cancers
#15
Ronghu Mao, Lingling Tian, You Zhang, Lei Ren, Renqi Gao, Fang-Fang Yin, Hong Ge
OBJECTIVE: The objective of this study is to theoretically and experimentally evaluate the dosimetry in the microscopic disease regions surrounding the tumor under stereotactic body radiation therapy of lung cancer. METHODS: For simplicity, the tumor was considered moving along 1 dimension with a periodic function. The probability distribution function of the tumor position was generated according to the motion pattern and was used to estimate the delivered dose in the microscopic disease region...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29328117/rotating-of-low-refractive-index-microparticles-with-a-quasi-perfect-optical-vortex
#16
Yansheng Liang, Ming Lei, Shaohui Yan, Manman Li, Yanan Cai, Zhaojun Wang, Xianghua Yu, Baoli Yao
Low-refractive-index microparticles, such as hollow microspheres, have shown great significance in some applications, such as biomedical sensing and targeted drug delivery. However, optical trapping and manipulation of low-refractive-index microparticles are challenging, owing to the repelling force exerted by typical optical traps. In this paper, we demonstrated optical trapping and rotating of large-sized low-refractive-index microparticles by using quasi-perfect optical vortex (quasi-POV) beams, which were generated by Fourier transform of high-order quasi-Bessel beams...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29327653/preparation-and-in-vitro-and-in-vivo-evaluation-of-quercetin-loaded-mixed-micelles-for-oral-delivery
#17
Zhen Lu, Cuiping Bu, Weicheng Hu, Hui Zhang, Mengrui Liu, Meiqi Lu, Guangxi Zhai
Quercetin (QT) is a plant polyphenol with various pharmacological properties. However, the low water solubility limits its therapeutic efficacy. In the present study, QT-loaded sodium taurocholate-Pluronic P123 (QT-loaded ST/P123) mixed micelles were developed and characterized, and the effect of the formulation on improving the water solubility of QT was investigated. QT-loaded ST/P123 mixed micelles were prepared by thin film hydration-direct dissolution and optimized by uniform design. The optimal formulation possessed high drug loading (12...
January 12, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29327220/patient-perceptions-and-preferences-for-a-mealtime-insulin-delivery-patch
#18
Mark Peyrot, Darlene Dreon, Vivien Zraick, Brett Cross, Meng H Tan
INTRODUCTION: A basal-bolus insulin regimen is needed to achieve glycated hemoglobin A1c (HbA1c) below 7.0% in people with type 1 (T1D) or type 2 (T2D) diabetes who have significant loss of beta-cell function. Nonadherence to therapy is common and negatively affects the ability to reach treatment goals. We examined patient assessment of a new, wearable mealtime insulin-delivery system (patch) relative to their current mealtime insulin-delivery system (syringe, pen, or pump). The patch is designed to deliver only boluses of fast-acting insulin (no basal insulin), mechanically controlled by the patient...
January 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29324869/exploring-the-binding-sites-and-binding-mechanism-for-hydrotrope-encapsulated-griseofulvin-drug-on-%C3%AE-tubulin-protein
#19
Shubhadip Das, Sandip Paul
The protein γ-tubulin plays an important role in centrosomal clustering and this makes it an attractive therapeutic target for treating cancers. Griseofulvin, an antifungal drug, has recently been used to inhibit proliferation of various types of cancer cells. It can also affect the microtubule dynamics by targeting the γ-tubulin protein. So far, the binding pockets of γ-tubulin protein are not properly identified and the exact mechanism by which the drug binds to it is an area of intense speculation and research...
2018: PloS One
https://www.readbyqxmd.com/read/29324608/quality-assurance-practices-in-obstetric-care-a-survey-of-hospitals-in-california
#20
Lisbet S Lundsberg, Henry C Lee, Grace Villarin Dueñas, Kimberly D Gregory, Holly K Grossetta Nardini, Christian M Pettker, Jessica L Illuzzi, Xiao Xu
OBJECTIVE: To assess hospital practices in obstetric quality management activities and identify institutional characteristics associated with utilization of evidence-supported practices. METHODS: Data for this study came from a statewide survey of obstetric hospitals in California regarding their organization and delivery of perinatal care. We analyzed responses from 185 hospitals that completed quality assurance sections of the survey to assess their practices in a broad spectrum of quality enhancement activities...
January 9, 2018: Obstetrics and Gynecology
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