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Ethnicity and coronary artery disease

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https://www.readbyqxmd.com/read/28917157/density-of-calcium-in-the-ascending-thoracic-aorta-and-risk-of-incident-cardiovascular-disease-events
#1
Isac C Thomas, Robyn L McClelland, Erin D Michos, Matthew A Allison, Nketi I Forbang, W T Longstreth, Wendy S Post, Nathan D Wong, Matthew J Budoff, Michael H Criqui
BACKGROUND AND AIMS: The volume and density of coronary artery calcium (CAC) both independently predict cardiovascular disease (CVD) beyond standard risk factors, with CAC density inversely associated with incident CVD after accounting for CAC volume. We tested the hypothesis that ascending thoracic aorta calcium (ATAC) volume and density predict incident CVD events independently of CAC. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of participants without clinical CVD at baseline...
September 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28899710/health-literacy-and-coronary-artery-disease-a-systematic-review
#2
REVIEW
Gabriela Lima de Melo Ghisi, Gabriela Suéllen da Silva Chaves, Raquel Rodrigues Britto, Paul Oh
OBJECTIVE: Identify health literacy (HL) screening instruments available to CAD patients; describe the prevalence of low HL; explore the predictors of low HL; and, identify the association between HL, health behaviors, and outcomes among these patients. METHODS: A literature search of electronic databases was conducted for published articles from database inception to February 2017. Eligible articles included the assessment of HL in CAD patients. Health behaviors and outcomes included diet, exercise, smoking, medication use, hospital readmission, knowledge, health-related quality of life (HRQoL), and psychosocial indicators...
September 6, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28864316/relation-of-diastolic-blood-pressure-and-coronary-artery-calcium-to-coronary-events-and-outcomes-from-the-multi-ethnic-study-of-atherosclerosis
#3
Faisal Rahman, Mahmoud Al Rifai, Michael J Blaha, Khurram Nasir, Matthew J Budoff, Bruce M Psaty, Wendy S Post, Roger S Blumenthal, John W McEvoy
Diastolic blood pressure has a J-curve relation with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic blood pressure, we hypothesized that the J-curve would be most pronounced in persons with coronary artery calcium. In 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic blood pressure category is associated with coronary heart disease events, stroke, and mortality. Analyses were conducted in the sample overall and after stratification by coronary artery calcium score...
August 8, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28860651/optimal-achieved-blood-pressure-for-patients-with-stable-coronary-artery-disease
#4
Chin-Chou Huang, Hsin-Bang Leu, Wei-Hsian Yin, Wei-Kung Tseng, Yen-Wen Wu, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Chau-Chung Wu, Jaw-Wen Chen
We aimed to investigate the ideal achieved blood pressure (BP) in ethnic Chinese patients with stable coronary artery disease (CAD) in Taiwan. A total of 2,045 patients (age 63.5 ± 11.9 years, 1,722 male [84.2%]) with stable CAD who had undergone percutaneous coronary interventions were enrolled. The achieved systolic BP was 130.6 ± 17.7 mmHg and diastolic BP was 74.9 ± 12.0 mmHg. In 12 months, patients with systolic BP < 120 mmHg and systolic BP ≥ 160 mmHg had increased risk of total cardiovascular events when compared to those with systolic BP 120-139 mmHg...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827117/association-of-cnb-5i-5d-promoter-gene-polymorphism-and-serum-calcineurin-levels-in-early-onset-of-coronary-artery-disease-of-south-indian-cohort
#5
Sailaja Maddhuri, Srinivas Bandaru, Chaitanya Bhukya, Vinod Cingeetham, Amaresh Rao Malempati, M L N Deepika, Pratibha Nallari, Hema Prasad Mundluru
Calcineurin, a serine/threonine phosphatase is a calcium dependent protein which on activation triggers transcriptional up regulation of inflammatory genes associated with inflammation in the arteries and progressive formation of plaques in CAD. The present investigation is aimed to study the possible association of Calcineurin encoding gene PPP3R1 (CnB 5I/5D) polymorphism in correlation with serum levels of calcineurin in coronary artery disease (CAD). A total of 300 angiographically documented CAD patients and 300 age, gender ethnicity matched healthy controls were recruited for the study...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28822562/underuse-of-effective-cardiac-medications-among-women-middle-aged-adults-and-racial-ethnic-minorities-with-coronary-artery-disease-from-the-national-health-and-nutrition-examination-survey-2005-to-2014
#6
Hoang V Tran, Molly E Waring, David D McManus, Nathaniel Erskine, Van T H Do, Catarina I Kiefe, Robert J Goldberg
Given the proven effectiveness of several cardiac medications for patients with coronary artery disease (CAD), we examined the national use of 4 classes of effective medications, overall and by age, sex, and race/ethnicity in 2005 to 2014. We used data from the National Health and Nutrition Examination Survey, including a self-reported diagnosis of CAD and independently verified medication use. Weighting procedures extrapolated our data to the adult US population with CAD. Analyses included 1,789 US adults aged ≥45 years with a history of CAD...
July 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28817241/association-between-vitamin-d-deficiency-and-heart-failure-risk-in-the-elderly
#7
Catarina Magalhães Porto, Vanessa De Lima Silva, João Soares Brito da Luz, Brivaldo Markman Filho, Vera Magalhães da Silveira
AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics. METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia...
August 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28814488/association-of-cardiovascular-disease-risk-factors-with-coronary-artery-calcium-volume-versus-density
#8
Isac C Thomas, Brandon Shiau, Julie O Denenberg, Robyn L McClelland, Philip Greenland, Ian H de Boer, Bryan R Kestenbaum, Gen-Min Lin, Michael Daniels, Nketi I Forbang, Dena E Rifkin, Jan Hughes-Austin, Matthew A Allison, J Jeffrey Carr, Joachim H Ix, Michael H Criqui
OBJECTIVES: Recently, the density score of coronary artery calcium (CAC) has been shown to be associated with a lower risk of cardiovascular disease (CVD) events at any level of CAC volume. Whether risk factors for CAC volume and CAC density are similar or distinct is unknown. We sought to evaluate the associations of CVD risk factors with CAC volume and CAC density scores. METHODS: Baseline measurements from 6814 participants free of clinical CVD were collected for the Multi-Ethnic Study of Atherosclerosis...
August 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28797404/coronary-artery-calcium-volume-and%C3%A2-density-potential-interactions-and-overall-predictive-value-the%C3%A2-multi-ethnic-study-of-atherosclerosis
#9
Michael H Criqui, Jessica B Knox, Julie O Denenberg, Nketi I Forbang, Robyn L McClelland, Thomas E Novotny, Veit Sandfort, Jill Waalen, Michael J Blaha, Matthew A Allison
OBJECTIVES: This study sought to determine the possibility of interactions between coronary artery calcium (CAC) volume or CAC density with each other, and with age, sex, ethnicity, the new atherosclerotic cardiovascular disease (ASCVD) risk score, diabetes status, and renal function by estimated glomerular filtration rate, and, using differing CAC scores, to determine the improvement over the ASCVD risk score in risk prediction and reclassification. BACKGROUND: In MESA (Multi-Ethnic Study of Atherosclerosis), CAC volume was positively and CAC density inversely associated with cardiovascular disease (CVD) events...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28794054/cardiovascular-event-prediction-by-machine-learning-the-multi-ethnic-study-of-atherosclerosis
#10
Bharath Ambale-Venkatesh, Xiaoying Yang, Colin O Wu, Kiang Liu, W G Hundley, Robyn L McClelland, Antoinette S Gomes, Aaron R Folsom, Steven Shea, Eliseo Guallar, David A Bluemke, João A Lima
Rationale: Machine learning may be useful to characterize cardiovascular risk, predict outcomes and identify biomarkers in population studies. Objective: To test the ability of random survival forests (RF), a machine learning technique, to predict six cardiovascular outcomes in comparison to standard cardiovascular risk scores. Methods and Results: We included participants from the Multi-Ethnic Study of Atherosclerosis (MESA). Baseline measurements were used to predict cardiovascular outcomes over 12 years of follow-up...
August 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28776137/ethnic-differences-in-the-risk-factors-and-severity-of-coronary-artery-disease-a-patient-based-study-in-iran
#11
Seyed Hesameddin Abbasi, Örjan Sundin, Arash Jalali, Joaquim Soares, Gloria Macassa
BACKGROUND: Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups. METHODS: In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were recruited. The demographic, laboratory, clinical, and risk factor data of all the patients were retrieved...
August 3, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28763798/meta-analysis-of-the-association-of-the-cyp2j2-g-50t-polymorphism-with-coronary-artery-disease
#12
Jian Chen, Dong-Fei Wang, Guo-Dong Fu, Jie Ding, Lei-Yang Chen, Jia-Lan Lv, Juan Fang, Xiang Yin, Xiao-Gang Guo
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754224/residual-atherosclerotic-cardiovascular-disease-risk-in-statin-treated-adults-the-multi-ethnic-study-of-atherosclerosis
#13
Nathan D Wong, Yanglu Zhao, Ruben G W Quek, Roger S Blumenthal, Matthew J Budoff, Mary Cushman, Parveen Garg, Veit Sandfort, Michael Tsai, J Antonio G Lopez
BACKGROUND: Residual atherosclerotic cardiovascular disease (ASCVD) risk in statin-treated US adults without known ASCVD is not well described. OBJECTIVE: To quantitate residual ASCVD risk and its predictors in statin-treated adults. METHODS: We studied 1014 statin-treated adults (53.3% female, mean 66.0 years) free of clinical ASCVD in the Multi-Ethnic Study of Atherosclerosis. We examined ASCVD event rates by National Lipid Association risk groups over 11-year follow-up and the relation of standard risk factors, biomarkers, and subclinical atherosclerosis measures with residual ASCVD event risk...
June 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28746709/association-of-coronary-artery-calcium-score-vs-age-with-cardiovascular-risk-in-older-adults-an-analysis-of-pooled-population-based-studies
#14
Yuichiro Yano, Christopher J O'Donnell, Lewis Kuller, Maryam Kavousi, Raimund Erbel, Hongyan Ning, Ralph D'Agostino, Anne B Newman, Khurram Nasir, Albert Hofman, Nils Lehmann, Klodian Dhana, Ron Blankstein, Udo Hoffmann, Stefan Möhlenkamp, Joseph M Massaro, Amir-Abbas Mahabadi, Joao A C Lima, M Arfan Ikram, Karl-Heinz Jöckel, Oscar H Franco, Kiang Liu, Donald Lloyd-Jones, Philip Greenland
Importance: Besides age, other discriminators of atherosclerotic cardiovascular disease (ASCVD) risk are needed in older adults. Objectives: To examine the predictive ability of coronary artery calcium (CAC) score vs age for incident ASCVD and how risk prediction changes by adding CAC score and removing only age from prediction models. Design, Setting, and Participants: We conducted an analysis of pooled US population-based studies, including the Framingham Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Cardiovascular Health Study...
July 26, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28727855/association-of-apoe-gene-polymorphism-with-lipid-profile-and-coronary-artery-disease-in-afro-caribbeans
#15
Laurent Larifla, Christophe Armand, Jacqueline Bangou, Anne Blanchet-Deverly, Patrick Numeric, Christiane Fonteau, Carl-Thony Michel, Séverine Ferdinand, Véronique Bourrhis, Fritz-Line Vélayoudom-Céphise
OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28677927/-the-placenta-a-new-target-organ-for-hypertension
#16
Laure Lyne Burdet, Manuella Epiney, Aurélie Bornand, Antoinette Pechère-Bertschi, Agnès Ditisheim
The placenta has generated many beliefs over centuries and in all ethnicities. Considered in our society as a surgical waste, it is elsewhere contemplated for its mysterious protective powers, viewed as the seat of the soul, disposed of, burnt or even buried. However, once time is taken for its examination, the placenta tells a story. Of interest is the similarity observed between placental vascular disease in hypertensive pregnancy and atherosclerosis in coronary artery disease for example. Hypertension in pregnancy is frequent and associated with increased adverse obstetrical outcomes, and long-term risk of cardiovascular and kidney disease...
September 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28666711/low-high-density-lipoprotein-cholesterol-and-particle-concentrations-are-associated-with-greater-levels-of-endothelial-activation-markers-in-multi-ethnic-study-of-atherosclerosis-participants
#17
Brian T Steffen, Suzette J Bielinski, Paul A Decker, Cecilia Berardi, Nicholas B Larson, James S Pankow, Erin D Michos, Naomi Q Hanson, David M Herrington, Michael Y Tsai
BACKGROUND: High-density lipoproteins (HDL) are well characterized for their role in reverse cholesterol transport but may confer other cardiovascular benefits-specifically, HDL may suppress the endothelial activation cascade in the initiating stages of atherogenesis. OBJECTIVE: It was the primary aim of this study to examine the relations of HDL cholesterol (HDL-C), total HDL particle (HDL-P) concentrations, and HDL-P subclasses with circulating levels of endothelial activation markers in a subcohort of Multi-Ethnic Study of Atherosclerosis participants...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28629624/the-protective-role-of-oestradiol-against-silent-myocardial-ischemia-and-hypertension-risk-in-south-african-men-the-sabpa-study
#18
Nicolaas T Malan, Roland von Känel, Hendrik S Steyn, Ruan Kruger, Leoné Malan
BACKGROUND: Oestradiol has a protective effect on coronary artery health in women but the effect it has on men, is controversial. A translational approach was followed to assess whether sex hormone levels are associated with silent myocardial ischemia (SMI) and hypertension risk over a 3year period. METHODS: Participants included 89 Black and 91 White men (aged 21-63years) participating in both phases of the Sympathetic activity and Ambulatory Blood Pressure in Africans prospective study...
June 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28624395/statin-trials-cardiovascular-events-and%C3%A2-coronary-artery-calcification-implications-for-a-trial-based-approach-to-statin-therapy-in%C3%A2-mesa
#19
Martin Bødtker Mortensen, Erling Falk, Dong Li, Khurram Nasir, Michael J Blaha, Veit Sandfort, Carlos Jose Rodriguez, Pamela Ouyang, Matthew Budoff
OBJECTIVES: This study sought to determine whether coronary artery calcium (CAC) could be used to optimize statin allocation among individuals for whom trial-based evidence supports efficacy of statin therapy. BACKGROUND: Recently, allocation of statins was proposed for primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on proven efficacy from randomized controlled trials (RCTs) of statin therapy, a so-called trial-based approach. METHODS: The study used data from MESA (Multi-Ethnic Study of Atherosclerosis) with 5,600 men and women, 45 to 84 years of age, and free of clinical ASCVD, lipid-lowering therapy, or missing information for risk factors at baseline examination...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28620990/association-patterns-of-endothelial-nitric-oxide-synthase-gene-nos3-variant-glu298asp-with-blood-pressure-and-serum-lipid-levels-in-subjects-with-coronary-artery-disease-from-pakistan
#20
Saleem Ullah Shahid, Abdul Rehman
Nitric oxide is an important antiatherosclerotic agent. The main determinant of nitric oxide levels is enzyme nitric oxide synthase encoded by the NOS3 gene, the common variants in this gene may be responsible for variations in plasma enzyme levels. The association of NOS3 variants with coronary artery disease (CAD) varies in different ethnicities. The current study aimed to determine the association of NOS3 Glu298Asp (rs1799983) with CAD and blood lipid levels in Pakistani subjects. Six hundred thirty-six samples (412 cases, 224 controls) were genotyped by TaqMan allelic discrimination assay and serum total cholesterol, and High Density Lipoprotein cholesterol (HDL-C)/Low Density Lipoprotein cholesterol (LDL-C) and triglycerides were measured...
July 2017: Annals of Human Genetics
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