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Ethnicity and coronary artery disease

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https://www.readbyqxmd.com/read/29748857/dynamic-of-changes-in-coronary-artery-calcification-in-early-rheumatoid-arthritis-patients-over-18-months
#1
Helen V Udachkina, Diana S Novikova, Tatiana V Popkova, Irina G Kirillova, Evgenia I Markelova
The coronary artery calcification (CAC) progression may be useful noninvasive predictor of future cardiovascular events (CVE). The progression rate of CAC in patients with early rheumatoid arthritis (RA) is poorly understood. To assess the dynamic of CAC scores in early RA patients for 18 months, 74 RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, with moderate/high RA activity, without prior administration of disease-modifying anti-rheumatic drugs or glucocorticoids) were enrolled within the framework of the observational study: women 73%, median age 56 years, median RA duration 6 months, median DAS28[ESR] 5...
May 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29740590/evaluation-of-71-coronary-artery-disease-risk-variants-in-a-multiethnic-cohort
#2
Wangjing Ke, Kristin A Rand, David V Conti, Veronica W Setiawan, Daniel O Stram, Lynne Wilkens, Loic Le Marchand, Themistocles L Assimes, Christopher A Haiman
Background: Coronary heart disease (CHD) is the most common cause of death worldwide. Previous studies have identified numerous common CHD susceptibility loci, with the vast majority identified in populations of European ancestry. How well these findings transfer to other racial/ethnic populations remains unclear. Methods and Results: We examined the generalizability of the associations with 71 known CHD loci in African American, Latino and Japanese men and women in the Multiethnic Cohort (6,035 cases and 11,251 controls)...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29728915/results-meta-analysis-and-a-first-evaluation-of-u-nox-r-the-urinary-nitrate-to-nitrite-molar-ratio-as-a-measure-of-nitrite-reabsorption-in-experimental-and-clinical-settings
#3
Dimitrios Tsikas, Erik Hanff, Alexander Bollenbach, Ruan Kruger, Vu Vi Pham, Kristine Chobanyan-Jürgens, Dirk Wedekind, Tanja Arndt, Anne Jörns, Jimmy F P Berbée, Hans M G Princen, Thomas Lücke, François Mariotti, Jean-François Huneau, Stefan Ückert, Jürgen C Frölich, Sigurd Lenzen
We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2 - ), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endothelium and decreased NO bioavailability in the circulation are considered major contributors to the development and progression of renal and cardiovascular diseases in different conditions including diabetes. Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2 O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO...
May 4, 2018: Amino Acids
https://www.readbyqxmd.com/read/29704026/the-relation-of-low-levels-of-bone-mineral-density-with-coronary-artery-calcium-and-mortality
#4
N Ahmadi, S S Mao, F Hajsadeghi, B Arnold, S Kiramijyan, Y Gao, F Flores, S Azen, M Budoff
Osteoporosis and atherosclerosis are two prevalent major healthcare concerns that frequently coexist. The clinical outcome of 5590 consecutive subjects who underwent coronary artery calcium (CAC) scanning and thoracic bone mineral density (BMD) measurement was assessed. A significant link between low BMD levels and CAC with increased risk of mortality in both genders across ethnicities noted. INTRODUCTION: While a relation of CAC with lower levels of BMD reported previously; it is unclear whether low levels of BMD would be an independent risk factor for CAC and mortality...
April 27, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29694442/epicardial-and-visceral-adipose-tissue-in-relation-to-subclinical-atherosclerosis-in-a-chinese-population
#5
Nang Ei Ei Khaing, Tai E Shyong, Jeannette Lee, Cinnie Yentia Soekojo, Alvin Ng, Rob M Van Dam
BACKGROUND: Body fatness is associated with risk of coronary heart disease and it has been postulated that epicardial adipose tissue (EAT) may have a particularly detrimental effect because of its localized toxic effects. We therefore aimed to examine the association between EAT and coronary artery calcification and compared this with associations for visceral adipose tissue (VAT) and other regional fat depots. METHODS: We conducted a cross-sectional study of 487 Chinese participants aged 50 years old and above, living in Singapore...
2018: PloS One
https://www.readbyqxmd.com/read/29688297/ten-year-association-of-coronary-artery-calcium-with-atherosclerotic-cardiovascular-disease-ascvd-events-the-multi-ethnic-study-of-atherosclerosis-mesa
#6
Matthew J Budoff, Rebekah Young, Gregory Burke, J Jeffrey Carr, Robert C Detrano, Aaron R Folsom, Richard Kronmal, Joao A C Lima, Kiang J Liu, Robyn L McClelland, Erin Michos, Wendy S Post, Steven Shea, Karol E Watson, Nathan D Wong
Aims: While coronary artery calcium (CAC) has been extensively validated for predicting clinical events, most outcome studies of CAC have evaluated coronary heart disease (CHD) rather than atherosclerotic cardiovascular disease (ASCVD) events (including stroke). Also, virtually all CAC studies are of short- or intermediate-term follow-up, so studies across multi-ethnic cohorts with long-term follow-up are warranted prior to widespread clinical use. We sought to evaluate the contribution of CAC using the population-based MESA cohort with over 10 years of follow-up for ASCVD events, and whether the association of CAC with events varied by sex, race/ethnicity, or age category...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29660517/cyp2d6-c2850t-g1846a-c100t-polymorphisms-haplotypes-and-mdr-analysis-in-predicting-coronary-artery-disease-risk-in-north-west-indian-population-a-case-control-study
#7
M A Bhat, G Gandhi
AIMS: The present study was aimed to evaluate the association of C2850T, G1846A and C100T polymorphisms of the CYP2D6 with coronary artery disease (CAD) in North-West Indian population. METHODS: In this case-control study, 200 patients with CAD and 200 age-, gender- and ethnicity-matched healthy controls were genotyped for C2850T, G1846A and C100T polymorphisms of CYP2D6 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: Genotype and allele distributions of C2850T and G1846A polymorphisms of the CYP2D6 were significantly different between cases and controls (p = 0...
April 13, 2018: Gene
https://www.readbyqxmd.com/read/29622982/cardiovascular-disease-and-abo-blood-groups-in-africans-are-blood-group-a-individuals-at-higher-risk-of-ischemic-disease-a-pilot-study
#8
Djibril Marie Ba, Mamadou Saidou Sow, Aminata Diack, Khadidiatou Dia, Mouhamed Cherif Mboup, Pape Diadie Fall, Moussa Daouda Fall
Background: Since the discovery of the ABO blood group system by Karl Landsteiner in 1901, several reports have suggested an important involvement of the ABO blood group system in the susceptibility to thrombosis. Assessing that non-O blood groups in particular A blood group confer a higher risk of venous and arterial thrombosis than group O.Epidemiologic data are typically not available for all racial and ethnics groups.The purpose of this pilot study was to identify a link between ABO blood group and ischemic disease (ID) in Africans, and to analyze whether A blood group individuals were at higher risk of ischemic disease or not...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29609131/hepatocyte-growth-factor-is-associated-with-progression-of-atherosclerosis-the-multi-ethnic-study-of-atherosclerosis-mesa
#9
Elizabeth J Bell, Paul A Decker, Michael Y Tsai, James S Pankow, Naomi Q Hanson, Christina L Wassel, Nicholas B Larson, Kevin P Cohoon, Matthew J Budoff, Joseph F Polak, James H Stein, Suzette J Bielinski
BACKGROUND AND AIMS: Hepatocyte growth factor (HGF) has previously been associated with risk of stroke, coronary heart disease, and atherosclerosis. We hypothesized that higher circulating HGF is associated with greater progression of measures of atherosclerosis: coronary artery calcium (CAC) and carotid plaque. METHODS: Participants aged 45-84 years from the prospective cohort study Multi-Ethnic Study of Atherosclerosis had HGF measured at baseline (between 2000 and 2002) and were followed for progression of atherosclerosis for up to 12 years...
March 23, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29593584/utilization-of-mental-health-care-treatment-patterns-and-course-of-psychosocial-functioning-in-northern-german-coronary-artery-disease-patients-with-depressive-and-or-anxiety-disorders
#10
Anna Lisa Westermair, Anja Schaich, Bastian Willenborg, Christina Willenborg, Stefan Nitsche, Heribert Schunkert, Jeanette Erdmann, Ulrich Schweiger
Background: Comorbid mental disorders in patients with coronary artery disease (CAD) are common and associated with adverse somatic outcomes. However, data on utilization rates of mental health care and treatment efficiency are scarce and inconsistent, which we tried to remedy with the present preliminary study on Northern German CAD patients. Method: A total of 514 German CAD patients, as diagnosed by cardiac catheterization, were assessed using the Mini International Neuropsychiatric Interview and the Global Assessment of Functioning (GAF) scale...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29579601/circulating-interleukin-6-is-a-biomarker-for-coronary-atherosclerosis-in-nonalcoholic-fatty-liver-disease-results-from-the-multi-ethnic-study-of-atherosclerosis
#11
Tracey G Simon, Maria Esther Perez Trejo, Robyn McClelland, Ryan Bradley, Michael J Blaha, Irfan Zeb, Kathleen E Corey, Matthew J Budoff, Raymond T Chung
BACKGROUND: Biomarkers to predict the presence and severity of subclinical cardiovascular disease (CVD) in nonalcoholic fatty liver disease (NAFLD) are lacking. METHODS: 3876 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), without known chronic liver disease underwent baseline non-contrast cardiac CT, with NAFLD defined by validated liver:spleen ratio (L:S) < 1.0, and subclinical CVD defined by coronary artery calcium (CAC) score > 0...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29564346/kawasaki-disease-among-egyptian-children-a-case-series
#12
Tarek Hamed Attia, Saed M Morsy, Bashier A Hassan, Al Shymaa A Ali
Kawasaki disease is an acute vasculitis of early childhood. Its incidence varies among different ethnic groups with higher rates among Asians. In this case series, we presented four cases of Kawasaki disease with incomplete or atypical presentations in Egyptian children. Two cases presented with meningitis, which is not a criteria for the diagnosis of Kawasaki disease. The other two cases presented with pharyngitis and fever, which did not respond to antibiotics. The clinical criteria for diagnosis of Kawasaki disease were either incomplete or appeared sequentially...
October 31, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29555305/basic-vs-more-complex-definitions-of-family-history-in-the-prediction-of-coronary-heart-disease-the-multi-ethnic-study-of-atherosclerosis
#13
Jaideep Patel, Mahmoud Al Rifai, Maren T Scheuner, Steven Shea, Roger S Blumenthal, Khurram Nasir, Michael J Blaha, John W McEvoy
OBJECTIVE: To determine whether family history of coronary heart disease (FH) definitions differ in their association with atherosclerotic cardiovascular disease (ASCVD) events. PATIENTS AND METHODS: Participants who provided FH data from July 17, 2000, through February 24, 2004, were identified. Definitions of FH were any, premature, and Familial Risk Assessment (FRA). Outcomes included coronary heart disease (CHD), stroke, peripheral artery disease, angina, and congestive heart failure...
March 16, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29541165/east-meets-west-the-influence-of-racial-ethnic-and-cultural-risk-factors-on-cardiac-surgical-risk-model-performance
#14
Sarah Soo-Hoo, Samantha Nemeth, Onur Baser, Michael Argenziano, Paul Kurlansky
Objective: To explore the impact of racial and ethnic diversity on the performance of cardiac surgical risk models, the Chinese SinoSCORE was compared with the Society of Thoracic Surgeons (STS) risk model in a diverse American population. Methods: The SinoSCORE risk model was applied to 13 969 consecutive coronary artery bypass surgery patients from twelve American institutions. SinoSCORE risk factors were entered into a logistic regression to create a 'derived' SinoSCORE whose performance was compared with that of the STS risk model...
2018: Heart Asia
https://www.readbyqxmd.com/read/29540426/high-density-lipoprotein-subspecies-defined-by-apolipoprotein-c-iii-and-subclinical-atherosclerosis-measures-mesa-the-multi-ethnic-study-of-atherosclerosis
#15
Sarah A Aroner, Manja Koch, Kenneth J Mukamal, Jeremy D Furtado, James H Stein, Matthew C Tattersall, Robyn L McClelland, Majken K Jensen
BACKGROUND: Apolipoprotein C-III (apoC-III), a small proinflammatory protein present on 6% to 7% of high-density lipoprotein (HDL) particles, defines a subspecies of HDL adversely associated with coronary heart disease in primarily white cohorts. In a multi-ethnic population free of clinical cardiovascular disease, we evaluated the relationship between apoC-III-defined HDL subspecies and subclinical markers of atherosclerotic pathology. METHODS AND RESULTS: We investigated cross-sectional associations between apolipoprotein A-I concentrations of apoC-III-defined HDL subspecies, measured via ELISA and imaging measures of subclinical atherosclerosis, among 4659 participants in the MESA (The Multi-Ethnic Study of Atherosclerosis) at baseline (2000-2002)...
March 14, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29527858/ethnicity-of-symptomatic-coronary-artery-disease-referred-for-coronary-angiography-in-the-galilee-prevalence-risk-factors-and-a-case-for-screening-and-modification
#16
Nizar Andria, Ali Nassar, Fabio Kusniec, Diab Ghanim, Dahud Qarawani, Erez Kachel, Khaled Taha, Offer Amir, Shemy Carasso
BACKGROUND: Coronary artery disease (CAD) has known risk factors. Individual risks related to specific ethnicities are complex and depend on genetic predisposition and lifestyle. OBJECTIVES: To compare the nature and prevalence of risk factors in Arab and non-Arab ethnic patients with symptomatic obstructive CAD referred for coronary angiography. METHODS: CAD, defined as coronary angiography with a ≥ 50% narrowing in ≥ 1 vessel, was diagnosed in 1029 patients admitted to a medical center between April 2014 and October 2015...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29523555/association-of-liver-fibrosis-with-cardiovascular-diseases-in-the-general-population-the-multi-ethnic-study-of-atherosclerosis-mesa
#17
Mohammad R Ostovaneh, Bharath Ambale-Venkatesh, Tomoki Fuji, Hooman Bakhshi, Ravi Shah, Venkatesh L Murthy, Russell P Tracy, Eliseo Guallar, Colin O Wu, David A Bluemke, João A C Lima
BACKGROUND: The association of cardiovascular diseases (CVD) with liver fibrosis is poorly understood. We aim to assess the association of liver fibrosis by T1-mapping magnetic resonance imaging and CVD in MESA (Multi-Ethnic Study of Atherosclerosis). METHODS AND RESULTS: MESA enrolled 6814 participants free of clinical CVD at baseline (2000-2002). A subsample of participants underwent T1-mapping magnetic resonance imaging 10 years after the baseline (Y10 MESA exam, 2010-2012)...
March 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29519347/10-year-resource-utilization-and-costs-for-cardiovascular-care
#18
Leslee J Shaw, Abhinav Goyal, Christina Mehta, Joe Xie, Lawrence Phillips, Anita Kelkar, Joseph Knapper, Daniel S Berman, Khurram Nasir, Emir Veledar, Michael J Blaha, Roger Blumenthal, James K Min, Reza Fazel, Peter W F Wilson, Matthew J Budoff
BACKGROUND: Cardiovascular disease (CVD) imparts a heavy economic burden on the U.S. health care system. Evidence regarding the long-term costs after comprehensive CVD screening is limited. OBJECTIVES: This study calculated 10-year health care costs for 6,814 asymptomatic participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a registry sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health. METHODS: Cumulative 10-year costs for CVD medications, office visits, diagnostic procedures, coronary revascularization, and hospitalizations were calculated from detailed follow-up data...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29505607/myeloperoxidase-mediated-hdl-oxidation-and-hdl-proteome-changes-do-not-contribute-to-dysfunctional-hdl-in-chinese-subjects-with-coronary-artery-disease
#19
Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun He, Wei Gao, Xiaodan Liu, Yanhong Guo, Jaeman Byun, Jifeng Zhang, Y Eugene Chen, Subramaniam Pennathur
High density lipoprotein (HDL) cholesterol levels and cholesterol efflux capacity (CEC) are inversely correlated with coronary artery disease (CAD) risk. Myeloperoxidase (MPO) derived oxidants and HDL proteome changes are implicated in HDL dysfunction in subjects with CAD in the United States; however, the effect of MPO on HDL function and HDL proteome in ethnic Chinese population is unknown. We recruited four matched ethnic Chinese groups (20 patients each): subjects with 1) low HDL levels (HDL levels in men <40mg/dL and women <50mg/dL) and non-CAD (identified by coronary angiography or cardiac CT angiography); 2) low HDL and CAD; 3) high HDL (men >50mg/dL; women >60mg/dL) with no CAD; and 4) high HDL with CAD...
2018: PloS One
https://www.readbyqxmd.com/read/29472232/genome-wide-association-and-functional-studies-identify-scml4-and-thsd7a-as-novel-susceptibility-genes-for-coronary-artery-disease
#20
Yang Li, Dao Wen Wang, Yundai Chen, Can Chen, Jian Guo, Shu Zhang, Zhijun Sun, Hu Ding, Yan Yao, Lei Zhou, Ke Xu, Chun Song, Fan Yang, Bin Zhao, Han Yan, Wen-Jing Wang, Chong Wu, Xiangfeng Lu, Xueli Yang, Jie Dong, Guyan Zheng, Shuhan Tian, Yanjun Cui, Lijuan Jin, Gangqiong Liu, Hanbin Cui, Shenghuang Wang, Feng Jiang, Changhua Wang, Jeanette Erdmann, Linyao Zeng, Shian Huang, Jianfeng Zhong, Yuehua Ma, Wenjiang Chen, Jianli Sun, Wei Lei, Shenghan Chen, Shaoqi Rao, Dongfeng Gu, Heribert Schunkert, Xiao-Li Tian
OBJECTIVE: The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS: We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 ( SCML4 [Scm polycomb group protein-like 4]; odds ratio, 1...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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