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https://www.readbyqxmd.com/read/29132425/establishment-of-a-medium-scale-mosquito-facility-optimization-of-the-larval-mass-rearing-unit-for-aedes-albopictus-diptera-culicidae
#1
Dongjing Zhang, Meichun Zhang, Yu Wu, Jeremie R L Gilles, Hanano Yamada, Zhongdao Wu, Zhiyong Xi, Xiaoying Zheng
BACKGROUND: Standardized larval rearing units for mosquito production are essential for the establishment of a mass-rearing facility. Two larval rearing units, developed respectively by the Guangzhou Wolbaki Biotech Co. Ltd. (Wolbaki) and Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (FAO/IAEA-IPCL), are tested to assess their potential uses to mass-rear the larval stages of Aedes albopictus in support of the establishment of a medium-scale mosquito facility for the application of mosquito genetic control strategies...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29116785/a-positive-allosteric-modulator-of-the-serotonin-5-ht2c-receptor-for-obesity
#2
Javier García-Cárceles, Juan M Decara, Henar Vázquez-Villa, Ramón Rodríguez, Eva Codesido, Jacobo Cruces, José Brea, María I Loza, Francisco Alén, Joaquin Botta, Peter J McCormick, Juan A Ballesteros, Bellinda Benhamú, Fernando Rodríguez de Fonseca, María L López-Rodríguez
The 5-HT2CR agonist lorcaserin, clinically approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the search for 5-HT2CR allosteric modulators as safer antiobesity drugs, a chemical library from Vivia Biotech was screened using ExviTech platform. Structural modifications of identified hit VA240 in synthesized analogues 6-41 afforded compound 11 (N-[(1-benzyl-1H-indol-3-yl)methyl]pyridin-3-amine, VA012), which exhibited dose-dependent enhancement of serotonin efficacy, no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands...
November 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28875019/protein-crystallography-and-drug-discovery-recollections-of-knowledge-exchange-between-academia-and-industry
#3
REVIEW
Tom L Blundell
The development of structure-guided drug discovery is a story of knowledge exchange where new ideas originate from all parts of the research ecosystem. Dorothy Crowfoot Hodgkin obtained insulin from Boots Pure Drug Company in the 1930s and insulin crystallization was optimized in the company Novo in the 1950s, allowing the structure to be determined at Oxford University. The structure of renin was developed in academia, on this occasion in London, in response to a need to develop antihypertensives in pharma...
July 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/28713787/consumers-preferences-for-a-local-food-product-the-case-of-a-new-carnaroli-rice-product-in-lombardy
#4
Giovanni Ferrazzi, Vera Ventura, Sabrina Ratti, Claudia Balzaretti
Italy, with a cultivated area of 218,000 ha, is a European leader of rice production. In particular Lombardy region accounts for 40% of total rice cultivation and the case study in object accounts for 3.2% of Lombardy total rice area (2773 ha). Starting from 2012, through a regional project titled Buono, Sano e Vicino (good, healthy and close), Riso e Rane rural district supported local rice farmers in developing innovation in rice production and promoting an alternative supply chain to increase farmers bargaining power and promote new market strategies...
April 13, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28552816/spanish-strategy-on-bioeconomy-towards-a-knowledge-based-sustainable-innovation
#5
REVIEW
Manuel Lainez, José Manuel González, Alfredo Aguilar, Carmen Vela
Spain launched its own strategy on bioeconomy in January 2016 aiming at boosting a bioeconomy based on the sustainable and efficient production and use of biological resources. It highlights global societal challenges related with agricultural and biotechnological sciences in Spain and the great dynamism of the private sectors involved, particularly the agri-food, biotech and biomass sectors. The targeted sectors are food, agriculture and forestry, conditioned by water availability. It also includes the production of those industrial bioproducts and bioenergy obtained from the use and valorisation of wastes and residues and other non-conventional sources of biomass, in a circular economy...
May 25, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28516274/evaluation-of-a-new-esophageal-stent-for-the-treatment-of-malignant-and-benign-esophageal-strictures
#6
Kun Yung Kim, Jiaywei Tsauo, Ho-Young Song, Jung-Hoon Park, Eun Jung Jun, Wei-Zhong Zhou, Min Tae Kim
PURPOSE: To evaluate the efficacy and safety of the EGIS esophageal stent for treating malignant and benign esophageal strictures. MATERIALS AND METHODS: Data of 73 patients (mean age 63.0 ± 11.9 years; 66 males) with malignant esophageal stricture and 16 patients (mean age 63.7 ± 9.5 years; 13 males) with benign esophageal stricture who received the EGIS esophageal stent (S&G Biotech, Seongnam, Korea) between October 2010 and April 2016 were obtained from a prospectively maintained electronic database...
October 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28473652/genetically-modified-foods-and-allergy
#7
REVIEW
T H Lee, H K Ho, T F Leung
2015 marked the 25th anniversary of the commercial use and availability of genetically modified crops. The area of planted biotech crops cultivated globally occupies a cumulative two billion hectares, equivalent to twice the land size of China or the United States. Foods derived from genetically modified plants are widely consumed in many countries and genetically modified soybean protein is extensively used in processed foods throughout the industrialised countries. Genetically modified food technology offers a possible solution to meet current and future challenges in food and medicine...
May 5, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28455953/biotechnology-for-bioenergy-dedicated-trees-meeting-future-energy-demands
#8
Hani Al-Ahmad
With the increase in human demands for energy, purpose-grown woody crops could be part of the global renewable energy solution, especially in geographical regions where plantation forestry is feasible and economically important. In addition, efficient utilization of woody feedstocks would engage in mitigating greenhouse gas emissions, decreasing the challenge of food and energy security, and resolving the conflict between land use for food or biofuel production. This review compiles existing knowledge on biotechnological and genomics-aided improvements of biomass performance of purpose-grown poplar, willow, eucalyptus and pine species, and their relative hybrids, for efficient and sustainable bioenergy applications...
April 29, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28420193/a-quantitative-pcr-electrochemical-genosensor-test-for-the-screening-of-biotech-crops
#9
Suely Moura-Melo, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, Arturo J Miranda-Ordieres, José Ribeiro Dos Santos Junior, Rosana A da Silva Fonseca, María Jesús Lobo-Castañón
The design of screening methods for the detection of genetically modified organisms (GMOs) in food would improve the efficiency in their control. We report here a PCR amplification method combined with a sequence-specific electrochemical genosensor for the quantification of a DNA sequence characteristic of the 35S promoter derived from the cauliflower mosaic virus (CaMV). Specifically, we employ a genosensor constructed by chemisorption of a thiolated capture probe and p-aminothiophenol gold surfaces to entrap on the sensing layer the unpurified PCR amplicons, together with a signaling probe labeled with fluorescein...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28298148/shaking-up-biotech-pharma-can-cues-be-taken-from-the-tech-industry
#10
C Katherine Wang
The biotech and pharma (biotech/pharma) industry is in dire need of finding ways to increase efficacy, efficiency, and affordability of its products. The information and technology industry ("tech") industry, which is an industry similarly founded on inventions and innovation, may provide some food for thought. This perspective will demonstrate the shift that biotech/pharma is already making and will propose that the industry has an opportunity to compel change by adopting some aspects of the tech industry with regards to models for technology/product development and leadership attributes...
June 2017: SLAS Technology
https://www.readbyqxmd.com/read/27809756/recent-patents-in-agricultural-biotechnology-focus-on-health
#11
Abdullah Makhzoum, Srividhya Venkataraman, Jocelyne Tremouillaux-Guiller, Kathleen Hefferon
BACKGROUND: Agricultural biotechnology, including the generation of genetically modified food crops, has been the subject of much controversy over the last few years. Initially serving the basic needs of farmers, Ag Biotech has more recently gained much appeal for its opportunities with respect to both the nutritional and pharmaceutical sciences. METHODS: The following review describes a number of recently approved patents that could have direct implications for the field of medicine...
2016: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/27585978/nonclinical-evaluation-of-pf-06438179-a-potential-biosimilar-to-remicade-%C3%A2-infliximab
#12
Mazin Derzi, Theodore R Johnson, Ahmed M Shoieb, Hugh D Conlon, Penny Sharpe, Andrew Saati, Sarah Koob, Michael W Bolt, Leslie G Lorello, Jim McNally, Carol F Kirchhoff, Teresa A Smolarek, Michael W Leach
INTRODUCTION: PF-06438179, a potential biosimilar to Remicade(®) (infliximab, Janssen Biotech, Inc.), is a chimeric mouse-human monoclonal antibody targeting human tumor necrosis factor alpha (TNF). METHODS: Analytical (small subset reported here) and nonclinical studies compared the structural, functional, and in vivo nonclinical similarity of PF-06438179 with Remicade sourced from the United States (infliximab-US) and/or European Union (infliximab-EU). RESULTS: The peptide map profiles were superimposable, and peptide masses were the same, indicating identical amino acid sequences...
November 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27524948/assessment-of-physicians-perceived-risk-of-inflammatory-bowel-disease-medications-in-pregnant-patients
#13
Robert Rhodes, Zachary Smith, Jaymes Adams, Julie Stoner, Tauseef Ali
UNLABELLED: Many female patients with inflammatory bowel disease (IBD) are affected during their reproductive years, and the benefits of continuing medical therapy to maintain remission during pregnancy generally outweigh the risks of therapy cessation. Knowledge of the current guidelines is important to maximize maternal and fetal outcomes. METHODS: A total of 116 practitioners (family medicine [FM], n = 35; internal medicine [IM], n = 22; obstetrics/gynecol-ogy [Ob/Gyn], n=23; gastroenterology [GI], n = 36) responded to a survey...
December 2014: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27306165/stem-cells-for-snoopy-pet-medicines-spark-a-biotech-boom
#14
Heidi Ledford
No abstract text is available yet for this article.
June 16, 2016: Nature
https://www.readbyqxmd.com/read/27066473/enhancements-needed-in-ge-crop-and-food-regulation-in-the-u-s
#15
REVIEW
Charles Benbrook
Genetically engineered (GE) crops, multi-ingredient foods derived from one or more GE ingredients, and GE agricultural inputs are regulated in the United States under a "Coordinated Framework" that was literally cobbled together in the early 1990s. Via this Framework, responsibility is spread across three federal agencies for the assessment and management of potential risks arising from the planting of GE crops, the raising of GE animals, or uses of GE inputs. The Framework was incomplete and conceptually flawed from the beginning...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27020644/a-roadmap-for-the-implementation-of-continued-process-verification
#16
Marcus Boyer, Joerg Gampfer, Abdel Zamamiri, Robin Payne
UNLABELLED: In 2014, the members of the BioPhorum Operations Group (BPOG) produced a 100-page continued process verification case study, entitled "Continued Process Verification: An Industry Position Paper with Example Protocol". This case study captures the thought processes involved in creating a continued process verification plan for a new product in response to the U.S. Food and Drug Administration's guidance on the subject introduced in 2011. In so doing, it provided the specific example of a plan developed for a new molecular antibody product based on the "A MAb Case Study" that preceded it in 2009...
May 2016: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/26887115/lichens-b-oligosaccharides-in-the-correction-of-metabolic-disorders-in-type-2-diabetes-mellitus
#17
RANDOMIZED CONTROLLED TRIAL
B M Kershengolts, L A Sydykova, V V Sharoyko, V V Anshakova, A V Stepanova, N A Varfolomeeva
INTRODUCTION: Lichens of the genus Cladonia are used as medicinal plants in folk medicine. Biologically active food supplement (BAFS) on the basis of lichens p. Cladonia was derived by mechanical-chemical biotechnology in the Educational-Research-Engineering Laboratory "Mechanical-Chemical Biotechnology" of the North-Eastern Federal University (NEFU). As a result of biotech impact, the solid β-glycoside bonds are destructed on β-oligosaccharide molecules, and other groups of lichen BAS is mobilized...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26458798/maternal-immunization-efforts-of-the-national-institutes-of-health
#18
REVIEW
Fran A Rubin, Marion Koso-Thomas, Maggie Brewinski Isaacs, Jeanna Piper, Jennifer Read, Mirjana Nesin
Over the last 35 years, efforts at the National Institutes of Health (NIH) to protect mothers and their infants against infectious diseases have involved a bench-to-bedside approach. Basic and translational research that provided a foundation for clinical trials of vaccines in pregnancy include natural history and vaccine antigen identification studies. Development of laboratory assays and reagents have been funded by NIAID; these are critical for the advancement of vaccine candidates through the preclinical and clinical steps along the maternal immunization research pathway to support vaccine efficacy...
November 25, 2015: Vaccine
https://www.readbyqxmd.com/read/26448073/cat-poop-coffee-goes-biotech
#19
(no author information available yet)
No abstract text is available yet for this article.
October 2015: Nature Biotechnology
https://www.readbyqxmd.com/read/26403092/sipuleucel-t-provenge-%C3%A2-autopsy-of-an-innovative-paradigm-change-in-cancer-treatment-why-a-single-product-biotech-company-failed-to-capitalize-on-its-breakthrough-invention
#20
Szymon Jarosławski, Mondher Toumi
Approved by the US Food and Drug Administration (FDA) in 2010, sipuleucel-T (Provenge(®)) was the first 'personalized' cancer vaccine for the treatment of prostate cancer in a metastatic, non-symptomatic population of 30,000 men in the USA. Sipuleucel-T is prepared individually for each patient and infused in three sessions over a period of 1 month. However, in 2015, Dendreon, the owner of sipuleucel-T, filed for bankruptcy. This opinion paper reviews the probable reasons this innovative product failed to achieve commercial success...
October 2015: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
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