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https://www.readbyqxmd.com/read/29139256/-correlative-analysis-advance-of-chemical-constituents-of-polyporus-umbellatus-and-armillaria-mellea
#1
REVIEW
Jing-Wen Huang, Chang-Jiang-Sheng Lai, Yuan Yuan, Min Zhang, Jun-Hui Zhou, Lu-Qi Huang
Medicinal Polyporus umbellatus is the dry sclerotia of P. umbellatus, with the effect of diuresis; Armillaria mellea is a parasitic fungus which can infect plants up to 300 genera, with sedative, anticonvulsant and some other biological activities. As the medicinal value of P. umbellatus and A. mellea is increasingly wide concerned, the market quantity demanded of them is gradually increased and the demand outstrips the supply. The symbiotic A. mellea and P. umbellatus are both the medicinal and edible fungi with diverse activities, including hypoglycemic action, improve immunity and antitumor and so on...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29138643/interactions-of-desmethoxyyangonin-a-secondary-metabolite-from-renealmia-alpinia-with-human-monoamine-oxidase-a-and-oxidase-b
#2
Narayan D Chaurasiya, Francisco León, Yuanqing Ding, Isabel Gómez-Betancur, Dora Benjumea, Larry A Walker, Stephen J Cutler, Babu L Tekwani
Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4'-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29137941/acute-and-sub-acute-oral-toxicity-studies-of-the-aqueous-extract-from-radix-radix-with-cortex-and-cortex-of-psammosilene-tunicoides-in-mice-and-rats
#3
Yi-Chen, Min-Xuan Wu, Jie-Liu, Xiao-Jie Ma, Jin-Li Shi, Sheng-Nan Wang, Zhi-Quan Zheng, Jian-You Guo
ETHNOPHARMACOLOGICAL RELEVANCE: Psammosilene tunicoides is one of the important ingredients of a famous Chinese traditional medicine formulation "Yunnan Baiyao". Also, this plant is commonly used as an anodyne and hemostatic agent in southwest China. Currently, little toxicological information is available on its safety following prolonged use. AIM OF THE STUDY: In this study, we sought to evaluate the toxicity of the three different parts of Psammosilene tunicoides: Psammosilenes Radix (PR), Psammosilenes Radix with Cortex (PRC) and Psammosilenes Cortex (PC) by acute and sub-acute toxicity studies...
November 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29137206/ancient-food-habits-dictate-that-food-can-be-medicine-but-medicine-cannot-be-food
#4
Hit Kishore Goswami, Hitendra Kumar Ram
Background: Extensive surveys of several population settlements in different parts of India-covering plains, mountains, valleys, river banks and deeper areas of forests at different altitudes-between 1968 and 2016 demonstrated that the basic vital need of hunger is being fulfilled since antiquity by plants in the wild. Methods: Based on collections, consultations with local population personnel and literature searches, this paper presents many plants that are commonly used as food and focuses on their products, which are rich in alkaloids, polysaccharides, steroids, terpenoids, flavonoids, aminoacids, fatty acids and antibiotics etc...
November 13, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29136659/predicting-the-distributions-of-egypt-s-medicinal-plants-and-their-potential-shifts-under-future-climate-change
#5
Emad Kaky, Francis Gilbert
Climate change is one of the most difficult of challenges to conserving biodiversity, especially for countries with few data on the distributions of their taxa. Species distribution modelling is a modern approach to the assessment of the potential effects of climate change on biodiversity, with the great advantage of being robust to small amounts of data. Taking advantage of a recently validated dataset, we use the medicinal plants of Egypt to identify hotspots of diversity now and in the future by predicting the effect of climate change on the pattern of species richness using species distribution modelling...
2017: PloS One
https://www.readbyqxmd.com/read/29134767/availability-and-approval-of-cannabis-based-medicines-for-chronic-pain-management-and-palliative-supportive-care-in-europe-a-survey-of-the-status-in-the-chapters-of-the-european-pain-federation
#6
N Krcevski-Skvarc, C Wells, W Häuser
BACKGROUND: There is considerable public and political interest in the use of cannabis products for medical purposes. METHODS: The task force of the European Pain Federation (EFIC) conducted a survey with its national chapters representatives on the status of approval of all types of cannabis-based medicines, the covering of costs and the availability of a position paper of a national medical association on the use of medical cannabis for chronic pain and for symptom control in palliative/supportive care...
November 13, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29134501/pharmacokinetic-properties-of-saffron-and-its-active-components
#7
Azar Hosseini, Bibi Marjan Razavi, Hossein Hosseinzadeh
Saffron as a medicinal plant has many therapeutic effects. Phytochemical studies have reported that saffron is composed of at least four active ingredients which include crocin, crocetin, picrocrocin and safranal. The carotenoids of saffron are sensitive to oxygen, light, heat and enzymatic oxidization. However, regulation of these factors is required for saffron quality. Some pharmacologic effects of saffron and its active compounds include cardioprotective, neuroprotective, memory enhancer, antidepressant and anxiolytic...
November 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29134131/medicinally-important-aromatic-plants-with-radioprotective-activity
#8
REVIEW
Ravindra M Samarth, Meenakshi Samarth, Yoshihisa Matsumoto
Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Looking into natural resources, particularly products of plant origin, has become an exciting area of research in drug discovery and development. Aromatic plants are mainly exploited for essential oil extraction for applications in industries, for example, in cosmetics, flavoring and fragrance, spices, pesticides, repellents and herbal beverages. Although several medicinal plants have been studied to treat various conventional ailments only a handful studies are available on aromatic plants, especially for radioprotection...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29133049/design-and-synthesis-of-novel-c14-urea-tetrandrine-derivatives-with-potent-anti-cancer-activity
#9
Junjie Lan, Lan Huang, Huayong Lou, Chao Chen, Tangjingjun Liu, Shengcao Hu, Yao Yao, Junrong Song, Jun Luo, Yazhou Liu, Bin Xia, Lei Xia, Xueyi Zeng, Yaacov Ben-David, Weidong Pan
Tetrandrine is a dibenzyltetrahydroisoquinoline alkaloid, isolated from traditional Chinese medicinal plant Stephania tetrandra, with anti-tumor activity. Our previous study identified several derivatives of tetrandrine showing better activities than parental compound against human hepatocellular carcinoma cells. To increase diversity and cytotoxic activities of the original compound, a series of novel 14-urea-tetrandrine derivatives were synthesized through structural modification of tetrandrine. These derivaties demonstrated a moderate to strong anti-proliferative activities against human cell lines HEL and K562 (Leukemia), prostate (PC3), breast (MDA-MB-231) and melanoma (WM9)...
November 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132906/a-selective-knockout-method-for-discovery-of-minor-active-components-from-plant-extracts-feasibility-and-challenges-as-illustrated-by-an-application-to-salvia-miltiorrhiza
#10
Xue-Yan Li, Hong-Jin Tang, Liu Zhang, Lin Yang, Ping Li, Jun Chen
Natural products have been recognized to play an invaluable role in drug discovery. However, efficient discovery of minor active constituents from natural sources is challenging due to the low abundance and complex matrices. In this study, we developed a selective knockout method to discover minor bioactive components from complex phytochemical mixtures, using a Chinese medicine as an example. Based on the chromatographic fingerprint, six major components in the ethyl acetate extract of the root of Salvia miltiorrhiza (EASM) were selectively knocked out via high-resolution peak fraction (HRPF) approach...
October 7, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29132827/high-performance-thin-layer-chromatographic-methods-in-the-evaluation-of-the-antioxidant-and-anti-hyperglycemic-activity-of-myrmecodia-platytyrea-as-a-promising-opportunity-in-diabetes-treatment
#11
S Agatonovic-Kustrin, D W Morton, A Adam, H H Mizaton, H Zakaria
The steady increase of diabetes is becoming a major burden on health care systems. As diabetic complications arise from oxidative stress, an antioxidant therapy along with anti-diabetic drugs is recommended. Myrmecodia or ant plant is highly valued as a traditional medicine in West Papua. It is used as an alternative treatment for diabetes, as the substances produced by ants can reduce blood sugar levels. The aim of this study was to develop and establish high-performance thin-layer chromatographic (HPTLC)-bioautographic methods to measure the antioxidant and hypoglycemic effects in different extracts from Myrmecodia platytyrea and to compare them with sterol content...
November 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29131618/np-structurepredictor-prediction-of-unknown-natural-products-in-plant-mixtures
#12
Yeu-Chern Harn, Bo-Han Su, Yuan-Ling Ku, Olivia A Lin, Cheng-Fu Chou, Yufeng Jane Tseng
Identification of the individual chemical constituents of a mixture, especially solutions extracted from medicinal plants, is a time-consuming task. The identification results are often limited by challenges such as the development of separation methods and the availability of known reference standards. A novel structure elucidation system, NP-StructurePredictor, is presented and used to accelerate the process of identifying chemical structures in a mixture based on a branch and bound algorithm combined with a large collection of natural product databases...
November 13, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29131443/a-systematic-review-of-randomized-controlled-trials-with-herbal-medicine-on-chronic-rhinosinusitis
#13
REVIEW
Majid Anushiravani, Mahdi Bakhshaee, Ali Taghipour, Hamideh Naghedi-Baghdar, Masoumeh Kaboli Farshchi, Seyed Saeed Hoseini, Mohammad Reza Mehri
Chronic rhinosinusitis (CRS) is a common disease with evidence to show that its incidence and prevalence are increasing. Medicinal plants are commonly used to treat CRS. This systematic review aimed to assess the effectiveness and safety of herbal preparations for treatment of the patients with CRS. Cochran, Embase, ISI, PubMed, and Scopus databases were searched until August 1, 2016. Only randomized controlled trials were included. Four randomized controlled trials were included in this systematic review. Various medicinal plants were studied in each article...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29131127/pleiotropic-effects-of-white-willow-bark-and-1-2-decanediol-on-human-adult-keratinocytes
#14
Eleonora Bassino, Franco Gasparri, Luca Munaron
BACKGROUND: Acne vulgaris is a common skin defect, usually occurring during adolescence, but often it can persist in adults leaving permanent face scarring. Acne is usually treated with topical drugs, oral antibiotics, retinoids, and hormonal therapies, but medicinal plants are increasingly employed. OBJECTIVE: To investigate the protective role of white willow bark (WWB) and 1,2-decanediol (DD) on the damage caused by lipopolysaccharides (LPS) on human adult keratinocytes (HaCaT)...
November 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29130757/international-barcode-of-life-focus-on-big-biodiversity-in-south-africa
#15
Sarah J Adamowicz, Peter M Hollingsworth, Sujeevan Ratnasingham, Michelle van der Bank
Participants in the 7th International Barcode of Life Conference (Kruger National Park, South Africa, 20-24 November 2017) share the latest findings in DNA barcoding research and its increasingly diversified applications. Here, we review prevailing trends synthesized from among 429 invited and contributed abstracts, which are collated in this open-access special issue of Genome. Hosted for the first time on the African continent, the 7th Conference places special emphasis on the evolutionary origins, biogeography, and conservation of African flora and fauna...
November 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29130543/medicinal-plants-of-the-genus-macleaya-macleaya-cordata-macleaya-microcarpa-a-review-of-their-phytochemistry-pharmacology-and-toxicology
#16
REVIEW
Li Lin, Yan-Chun Liu, Jia-Lu Huang, Xiu-Bin Liu, Zhi-Xing Qing, Jian-Guo Zeng, Zhao-Ying Liu
In the genus Macleaya, Macleaya cordata and Macleaya microcarpa have been recognized as traditional herbs that are primarily distributed in China, North America, and Europe and have a long history of medicinal usage. These herbs have been long valued and studied for detumescence, detoxification, and insecticidal effect. This review aims to provide comprehensive information on botanical, phytochemical, pharmacological, and toxicological studies on plants in the genus Macleaya. Plants from the genus of Macleaya provide a source of bioactive compounds, primarily alkaloids, with remarkable diversity and complex architectures, thereby having attracted attention from researchers...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29130346/chemical-composition-and-evaluation-of-antinociceptive-activity-of-the-essential-oil-of-stevia-serrata-cav-from-guatemala
#17
Daniel Luiz Reis Simas, Max Samuel Mérida-Reyes, Manuel Alejandro Muñoz-Wug, Millena Santos Cordeiro, Thais Biondino Sardella Giorno, Edwin Adolfo Taracena, Bessie Evelyn Oliva-Hernández, José Vicente Martínez-Arévalo, Patricia Dias Fernandes, Juan Francisco Pérez-Sabino, Antonio Jorge Ribeiro da Silva
The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil was obtained by hydrodistillation of the dried aerial parts of the plant. The essential oil analysed by GC-FID and GC-MS showed a high content of sesquiterpenoids, with chamazulene (60.1%) as the major component and 91.5% of the essential oil composition was identified. To evaluate antinociceptive activity in mice, the essential oil of S...
November 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29129935/antimalarial-use-of-malagasy-plants-is-poorly-correlated-with-performance-in-antimalarial-bioassays
#18
Wendy L Applequist, Michel Ratsimbason, Alyse Kuhlman, Stephan Rakotonandrasana, Vincent Rasamison, David G I Kingston
Bioassay screening of plant extracts can identify unique lead compounds for drug development, but the "hit rate" from random screening is very low. Targeted screening of medicinal plants has been repeatedly reported to increase the percentage of samples displaying bioactivity. Contrarily, Maranz (2012) suggested that African antimalarial plants were unsuitable sources of antimalarial drugs because high prevalence of malaria would result in rapid evolution of resistance to active compounds that directly targeted the parasite...
March 2017: Economic Botany
https://www.readbyqxmd.com/read/29129665/intravasation-of-sw620-colon-cancer-cell-spheroids-through-the-blood-endothelial-barrier-is-inhibited-by-clinical-drugs-and-flavonoids-in-vitro
#19
Silvio Holzner, Stefan Brenner, Atanas Georgiev Atanasov, Daniel Senfter, Serena Stadler, Chi Huu Nguyen, Adryan Fristiohady, Daniela Milovanovic, Nicole Huttary, Sigurd Krieger, Zsuzsanna Bago-Horvath, Oliver de Wever, Ioannis Tentes, Ali Özmen, Walter Jäger, Helmut Dolznig, Verena Maria Dirsch, Robert Michael Mader, Liselotte Krenn, Georg Krupitza
Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell (BEC) barrier breaching by CRC emboli, an in vitro assay measuring BEC-free areas underneath SW620 cell spheroids, so called "circular chemorepellent induced defects" (CCIDs, appearing in consequence of endothelial retraction), was adapted and supported by Western blotting, EIA-, EROD- and luciferase reporter assays. Inhibition of ALOX12 or NF-κB in SW620 cells or BECs, respectively, caused attenuation of CCIDs...
November 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29128822/a-doc-coagulant-gypsum-treatment-can-simultaneously-reduce-as-cd-and-pb-uptake-by-medicinal-plants-grown-in-contaminated-soil
#20
Hyuck Soo Kim, Byoung-Hwan Seo, Saranya Kuppusamy, Yong Bok Lee, Jae-Hwang Lee, Jae-E Yang, Gary Owens, Kwon-Rae Kim
The efficiency of gypsum, as a dissolved organic carbon (DOC) coagulator, for the simultaneous immobilization of two heavy metals (Cd and Pb) and one metalloid (As) in agricultural soils near an abandoned mining site was examined. The agricultural soil was defined as long-term contaminated as As (1540mgkg(-1)), Cd (55mgkg(-1)) and Pb (1283mgkg(-1)) concentrations exceeded the Korean guideline values for As (25mgkg(-1)), Cd (4mgkg(-1)), and Pb (200mgkg(-1)). Gypsum was incorporated into the contaminated soil at 3% (w/w)...
November 9, 2017: Ecotoxicology and Environmental Safety
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