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https://www.readbyqxmd.com/read/29241704/development-and-characterization-of-an-anthropomorphic-breast-phantom-for-permanent-breast-seed-implant-brachytherapy-credentialing
#1
Michael Roumeliotis, Sarah Quirk, Matthew Skarsgard, Tiana Trumpour, Elizabeth Watt, Tyler Meyer
PURPOSE: To develop an anthropomorphic breast phantom for use in credentialing of permanent breast seed implant brachytherapy. METHODS AND MATERIALS: A representative external contour and target volume was used as the basis of mold manufacturing for anthropomorphic breast phantom development. Both target and normal tissue were composed of gel-like materials that provide suitable computed tomography and ultrasound contrast for brachytherapy delivery. The phantoms were evaluated for consistency in construction (target location) and Hounsfield unit (computed tomography contrast)...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29240873/preliminary-results-of-the-use-of-a-stabilized-hypochlorous-acid-solution-in-the-management-of-ralstonia-pickettii-biofilm-on-silicone-breast-implants
#2
C Tod Brindle, Steve Porter, Kiran Bijlani, Sridhar Arumugam, Rowena Matias, Ron Najafi, Jack Fisher
Background: Ralstonia Pickettii biofilms are associated with pocket infections following breast implant surgeries. Biofilm protects bacteria most topically applied antimicrobial irrigations. Objectives: To evaluate the effectiveness of four antimicrobial solutions on the planktonic form and established biofilm of Ralstonia Pickettii grown on 3 different types of silicone breast implants. Methods: Time kill assays at clinical concentrations of chlorhexidine gluconate, povidone iodine, triple-antibiotic solution, and a 0...
December 12, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29240639/absorbable-antibiotic-beads-prophylaxis-in-immediate-breast-reconstruction
#3
Denise M Kenna, Busayo Irojah, Kimber Lee Mudge, Kendra Eveler
BACKGROUND: Breast reconstruction with tissue expander is the most common mode of reconstruction following mastectomy. Infection necessitating tissue expander removal is a significant complication leading to patient distress as well as increased health care costs. METHODS: Over 3 years, 127 breast reconstructions with tissue expanders were performed by a single surgeon. Fifty-nine of these reconstructions were performed using a standardized protocol in which patients washed with chlorhexidine several days prior to surgery and received intravenous antibiotics preoperatively...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29240638/antibiotic-prophylaxis-after-immediate-breast-reconstruction-the-reality-of-its-efficacy
#4
Kavitha Ranganathan, Erika D Sears, Lin Zhong, Ting-Ting Chung, Kevin C Chung, Jeffrey H Kozlow, Adeyiza O Momoh, Jennifer F Waljee
PURPOSE: Numerous techniques are used to prevent infection after immediate implant-based breast reconstruction. Postoperative antibiotic prophylaxis (PAP) is commonly prescribed to decrease the risk of reconstructive failure, despite conflicting evidence regarding its effectiveness. We sought to determine whether PAP decreases the risk of infection-related explantation in the setting of immediate prosthesis-based breast reconstruction. METHODS: Using Truven MarketScan databases, we identified all patients who underwent immediate implant reconstruction between 1/2010-6/2014 with at least 6 months of follow-up...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29239797/autologous-breast-reconstruction-using-the-immediately-lipofilled-extended-latissimus-dorsi-flap
#5
N Johns, N Fairbairn, M Trail, A Ewing, L Yong, C Raine, J M Dixon
BACKGROUND: The latissimus dorsi flap is a popular choice for autologous breast reconstruction. To dramatically improve volume, we report our experience of using the immediately lipofilled extended latissimus dorsi (ELD) flap and show it as a valid option for autologous breast reconstruction. METHODS: Patients undergoing the procedure between December 2013 and June 2016 were included. Demographic, clinical and operative factors were analysed, together with in-hospital morbidity and duration of postoperative hospital stay...
November 24, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29233522/subcutaneous-implant-based-breast-reconstruction-a-modern-challenge-in-postmastectomy-radiation-planning
#6
Melissa P Mitchell, Jamie Wagner, James Butterworth
PURPOSE: A growing trend in breast reconstruction has been placement of tissue expanders in the pre pectoral space. This is a change from the practice of placement under the pectoralis major with or without an acellular dermal matrix (ADM) sling. The move toward pre pectoral placement with an ADM wrap has the intent of decreasing post-operative pain and decreasing animation deformities. The cosmesis of pre pectoral reconstructions in the setting of post mastectomy radiation has also appeared improved in our early experience, when compared to submuscular reconstructions...
September 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29229179/clinical-role-of-breast-mri-now-and-going-forward
#7
REVIEW
D Leithner, G J Wengert, T H Helbich, S Thakur, R E Ochoa-Albiztegui, E A Morris, K Pinker
Magnetic resonance imaging (MRI) is a well-established method in breast imaging, with manifold clinical applications, including the non-invasive differentiation between benign and malignant breast lesions, preoperative staging, detection of scar versus recurrence, implant assessment, and the evaluation of high-risk patients. At present, dynamic contrast-enhanced MRI is the most sensitive imaging technique for breast cancer diagnosis, and provides excellent morphological and to some extent also functional information...
December 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29225983/breast-implant-associated-anaplastic-large-cell-lymphoma-a-case-report-and-review-of-the-literature
#8
Daniel E Ezekwudo, Tolulope Ifabiyi, Bolanle Gbadamosi, Kristle Haberichter, Zhou Yu, Mitual Amin, Kenneth Shaheen, Michael Stender, Ishmael Jaiyesimi
Breast implant-associated anaplastic large T-cell lymphoma has recently been recognized as an entity, with few reports describing the two common subtypes: in situ (indolent) and infiltrative. Recently, the infiltrative subtypes have been shown to be more aggressive requiring adjuvant chemotherapy. We report a rare case of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in a 65-year-old Caucasian female following silicone breast implantation and multiple capsulectomies. We discuss the rare presentation of this disease, histopathologic features of the indolent and infiltrative subtypes of ALCL, and their clinical significance...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29223731/permeability-of-expander-breast-implants-in-vitro-and-in-vivo-analyses
#9
Lionel Tortolano, Stéphanie Yen-Nicolaÿ, Pierre-François Rogliano, Heba Alkhashnam, Jean-François Honart, Katia Manerlax, Françoise Rimareix, François Lemare, Najet Yagoubi
INTRODUCTION: The biocompatibility of the polysiloxane breast implant has been studied moderately. The aging of these implants due to lipid penetration and the release of polymerization impurities, such as Platine or octamethylcyclotetrasiloxane (named D4), has already been documented. Since these studies, manufacturing procedures have been improved; thus, the security of breast implants has also improved. Although polymerization and the choice of monomer influence the shell properties, few studies have compared these together in breast implants...
December 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29223506/treatment-planning-considerations-for-permanent-breast-seed-implant
#10
Amy Frederick, Tyler Meyer, Michael Roumeliotis
PURPOSE: To determine an optimal planning strategy for permanent breast seed implant that minimizes dose heterogeneity without degrading coverage and conformity. METHODS AND MATERIALS: A simple model was developed to investigate planning strategies incorporating a range of 103Pd seed activities, needle and seed spacings, and implants in which seed positions are either restricted to or permitted outside of spherical planning target volumes (PTVs). To address more realistic target geometries, model parameters were used to retrospectively replan a 10-patient cohort in MIM Symphony...
December 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29218286/experience-of-breast-augmentation-in-pakistani-females
#11
Muhammad Ahmad
BACKGROUND: Breast augmentation is an elective surgery used to increase the size of the breast in females. This study was undertaken to determine the breast augmentation in Pakistani females. METHODS: From 2006 to 2011, 43 female patients who underwent breast augmentation via infra-mammary, periareolar, trans-umbilical and fat transfer were enrolled. For augmentation, saline-filled or gel-filled implants were used in the supine position under general anesthesia and local infiltration of adrenaline (1:100,000 dilution) on each side...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29212525/establishing-and-characterizing-patient-derived-xenografts-using-pre-chemotherapy-percutaneous-biopsy-and-post-chemotherapy-surgical-samples-from-a-prospective-neoadjuvant-breast-cancer-study
#12
Jia Yu, Bo Qin, Ann M Moyer, Jason P Sinnwell, Kevin J Thompson, John A Copland, Laura A Marlow, James L Miller, Ping Yin, Bowen Gao, Katherine Minter-Dykhouse, Xiaojia Tang, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Anthony Schweitzer, Yan Lu, Jason Hubbard, Donald W Northfelt, Richard J Gray, Katie Hunt, Amy L Conners, Vera J Suman, Krishna R Kalari, James N Ingle, Zhenkun Lou, Daniel W Visscher, Richard Weinshilboum, Judy C Boughey, Matthew P Goetz, Liewei Wang
BACKGROUND: Patient-derived xenografts (PDXs) are increasingly used in cancer research as a tool to inform cancer biology and drug response. Most available breast cancer PDXs have been generated in the metastatic setting. However, in the setting of operable breast cancer, PDX models both sensitive and resistant to chemotherapy are needed for drug development and prospective data are lacking regarding the clinical and molecular characteristics associated with PDX take rate in this setting...
December 6, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29208440/radiotherapy-in-the-setting-of-breast-reconstruction-types-techniques-and-timing
#13
REVIEW
Alice Y Ho, Zishuo I Hu, Babak J Mehrara, Edwin G Wilkins
As the use of breast reconstruction and postmastectomy radiotherapy (PMRT) has increased over the past decade, the typical approach to integrating radiotherapy with breast reconstruction has provoked intense controversy in the management of breast cancer. PMRT can lead to an increased frequency of complications in the reconstructed breast. Conversely, the reconstructed breast can increase the complexity of radiotherapy delivery. How to minimise the frequency of complications without compromising oncological or cosmetic outcomes of the reconstructed breast is an important shared multidisciplinary goal for oncologists and their patients...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29205748/cosmetic-tourism-for-breast-augmentation-a-systematic-review
#14
REVIEW
Louise Brightman, Sze Ng, Susannah Ahern, Rodney Cooter, Ingrid Hopper
BACKGROUND: The medical tourism industry, and in particular cosmetic tourism for breast augmentation, is becoming an increasingly popular global phenomenon. The objective of this study is to determine the extent of medical literature and the patient risk profiles associated with cosmetic tourism for breast augmentation both locally and abroad. DATA SOURCES: OVID MEDLINE, OVID Embase, Cochrane Central and Proquest electronic databases. METHODS: The search was conducted through to April 2017...
December 3, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29204163/efficacy-of-single-stage-breast-conserving-treatment-using-multicatheter-partial-breast-brachytherapy-evaluated-by-gec-estro-phase-3-trial
#15
Kazuhiko Sato, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo, Jun Kubota, Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa
Purpose: The GEC-ESTRO has reported the equivalent outcomes of partial breast irradiation (PBI) using multicatheter interstitial brachytherapy (MCB) to whole breast irradiation (WBI) in breast-conserving therapy (BCT). We performed single-stage BCT with partial breast brachytherapy by intraoperative catheter placement. After the categorization of patients into inclusion and exclusion criteria on this trial, our databases were evaluated in order to translate it to Japanese patients. Material and methods: Patients undergoing BCT were retrospectively examined between November 2007 and December 2015...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29202621/the-clinical-database-and-implementation-of-treatment-guidelines-by-the-danish-breast-cancer-cooperative-group-in-2007-2016
#16
Maj-Britt Jensen, Anne-Vibeke Laenkholm, Birgitte V Offersen, Peer Christiansen, Niels Kroman, Henning T Mouridsen, Bent Ejlertsen
BACKGROUND: Since 40 years, Danish Breast Cancer Cooperative Group (DBCG) has provided comprehensive guidelines for diagnosis and treatment of breast cancer. This population-based analysis aimed to describe the plurality of modifications introduced over the past 10 years in the national Danish guidelines for the management of early breast cancer. By use of the clinical DBCG database we analyze the effectiveness of the implementation of guideline revisions in Denmark. METHODS: From the DBCG guidelines we extracted modifications introduced in 2007-2016 and selected examples regarding surgery, radiotherapy (RT) and systemic treatment...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29196176/assessing-value-in-breast-reconstruction-a-systematic-review-of-cost-effectiveness-studies
#17
Clifford C Sheckter, Evan Matros, Arash Momeni
INTRODUCTION: Breast reconstruction is one of the most common procedures performed by plastic surgeons and is achieved through various choices in both technology and method. Cost-effectiveness analyses are increasingly important in assessing differences in value between treatment options, which is relevant in a world of confined resources. A thorough evaluation of the cost-effectiveness literature can assist surgeons and health systems evaluate high-value care models. METHODS: A systematic review of PubMed, Web of Science, and the Cost-Effectiveness Analysis Registry was conducted...
October 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29194092/clinicopathologic-features-and-prognostic-impact-of-lymph-node-involvement-in-patients-with-breast-implant-associated-anaplastic-large-cell-lymphoma
#18
Maria C Ferrufino-Schmidt, L Jeffrey Medeiros, Hui Liu, Mark W Clemens, Kelly K Hunt, Camille Laurent, Julian Lofts, Mitual B Amin, Siaw Ming Chai, Angela Morine, Arianna Di Napoli, Ahmet Dogan, Vinita Parkash, Govind Bhagat, Denise Tritz, Andres E Quesada, Sergio Pina-Oviedo, Qinlong Hu, Francisco J Garcia-Gomez, Juan Jose Borrero, Pedro Horna, Beenu Thakral, Marina Narbaitz, R Condon Hughes, Li-Jun Yang, Jonathan R Fromm, David Wu, Da Zhang, Aliyah R Sohani, John Hunt, Indira U Vadlamani, Elizabeth A Morgan, Judith A Ferry, Reka Sziget, Juan C Tardio, Rosario Granados, Susanne Dertinger, Felix A Offner, Andreas Pircher, Jeff Hosry, Ken H Young, Roberto N Miranda
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL...
November 29, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29190331/breast-erythema-in-a-patient-with-breast-implant-associated-anaplastic-large-cell-lymphoma-a-case-report-discussing-cutaneous-manifestations
#19
Sarah M Elswick, Minh-Doan T Nguyen
HASH(0x492c4e8)
November 28, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29190321/hypochlorous-acid-versus-povidone-iodine-containing-irrigants-which-antiseptic-is-more-effective-for-breast-implant-pocket-irrigation
#20
Honghua Hu, Janine Sleiman, Khalid Johani, Karen Vickery
Background: Capsular contracture induced by chronic subclinical infection is a major cause of poor outcomes and reoperation in breast implant surgery. The use of pocket irrigation with antiseptic/antibiotic has been shown to reduce the incidence of contracture. A new formulation of hypochlorous acid solution PhaseOne has been proposed as potential agent for irrigation. Objectives: This study aimed to test the efficacy of hypochlorous acid solution PhaseOne for use in breast pocket irrigation as an alternative to povidone iodine solution Betadine...
November 28, 2017: Aesthetic Surgery Journal
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