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https://www.readbyqxmd.com/read/27870810/neonatal-group-b-streptococcus-infections-prevention-strategies-clinical-and-microbiologic-characteristics-in-7-years-of-surveillance
#1
Roberta Creti, Monica Imperi, Alberto Berardi, Marco Pataracchia, Simona Recchia, Giovanna Alfarone, Lucilla Baldassarri
BACKGROUND: The characteristics of group B streptococcus (GBS) neonatal disease in a period of 7 years are reported. METHODS: The estimation of the neonatal GBS disease risk and prevention strategies adopted at delivery in absence of national guidelines were evaluated by the analysis of 3501 questionnaires. Notification of 194 neonatal GBS infections was recorded. In addition, 115 strains from neonatal early and late onset disease (EOD and LOD, respectively) plus 320 strains from pregnant women were analyzed by molecular typing methods and for antibiotic resistance...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27748684/maternal-exposure-to-aeroallergens-and-the-risk-of-early-delivery
#2
Eric Lavigne, Antonio Gasparrini, David M Stieb, Hong Chen, Abdool S Yasseen, Eric Crighton, Teresa To, Scott Weichenthal, Paul J Villeneuve, Sabit Cakmak, Frances Coates, Mark Walker
BACKGROUND: Daily changes in aeroallergens during pregnancy could trigger early labor, but few investigations have evaluated this issue. This study aimed to investigate the association between exposure to aeroallergens during the week preceding birth and the risk of early delivery among preterm and term pregnancies. METHODS: We identified data on 225,234 singleton births that occurred in six large cities in the province of Ontario, Canada, from 2004 to 2011 (April to October) from a birth registry...
January 2017: Epidemiology
https://www.readbyqxmd.com/read/27157153/the-relationship-between-maternal-employment-status-and-pregnancy-outcomes
#3
Farnoush Khojasteh, Azizollah Arbabisarjou, Tahere Boryri, Amneh Safarzadeh, Mohammad Pourkahkhaei
BACKGROUND & OBJECTIVES: Women comprise a large percentage of the workforce in industrial countries. In Europe and many other places in the world, women of reproductive age comprise a significant proportion of the workforce at the workplaces, and the rules and regulations require employers to evaluate and minimize health risks to pregnant women. In U.K, 70%, and in the United States 59% of women are employed. In Iran, 13% of women are employed, which comes down to less than 5% at Sistan& Baluchestan Province...
September 1, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27019202/modeling-magnetomyograms-of-uterine-contractions-during-pregnancy-using-a-multiscale-forward-electromagnetic-approach
#4
Mengxue Zhang, Vanessa Tidwell, Patricio S La Rosa, James D Wilson, Hari Eswaran, Arye Nehorai
Understanding the mechanisms of uterine contractions during pregnancy is especially important in predicting the onset of labor and thus in forecasting preterm deliveries. Preterm birth can cause serious health problems in newborns, as well as large financial burdens to society. Various techniques such as electromyography (EMG) and magnetomyography (MMG) have been developed to quantify uterine contractions. However, no widely accepted method to predict labor based on electromagnetic measurement is available...
2016: PloS One
https://www.readbyqxmd.com/read/26859152/demographic-and-behavioral-predictors-of-severe-fetomaternal-hemorrhage-a-case-control-study
#5
Annemarie Stroustrup, Callie Plafkin, Thuy-An Tran, David A Savitz
BACKGROUND: Fetomaternal hemorrhage (FMH) signifies failure of the placental barrier with whole blood transfer. Fetal anemia following FMH is associated with significant morbidity and mortality. If FMH is identified early, fetal anemia can be treated to minimize adverse outcomes. Risk factors for FMH are not known, limiting efforts to provide targeted screening for FMH. OBJECTIVE: To identify maternal and/or pregnancy characteristics associated with FMH that are recognizable prior to fetal morbidity...
2016: Neonatology
https://www.readbyqxmd.com/read/26760526/the-choice-of-amniotic-fluid-in-metabolomics-for-the-monitoring-of-fetus-health
#6
Francesco Palmas, Claudia Fattuoni, Antonio Noto, Luigi Barberini, Angelica Dessì, Vassilios Fanos
Amniotic fluid (AF) is a biological fluid in which metabolite transport is regulated by the placenta, the permeable skin, fetal lung egress and gastric fluid. During pregnancy, the composition of AF changes from similar to the interstitial fluid of the mother, to a more complex system, influenced by the fetus's urine. Since AF reflects the mother's and the fetus's health status at the same time, it may be an important diagnostic tool for a wider spectrum of clinical conditions. Indeed, the metabolic characterization of AF in relation to pathological occurrences may lead to the discovery of new biomarkers for a better clinical practice...
2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/26721546/patient-satisfaction-and-psychological-well-being-after-internet-based-cognitive-behavioral-stress-management-ib-cbsm-for-women-with-preterm-labor-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
S Scherer, J Alder, J Gaab, T Berger, K Ihde, C Urech
OBJECTIVE AND METHODS: Despite its value for the management of psychological burden, little is known about the efficacy of and patient satisfaction with internet-based cognitive behavioral stress management (IB-CBSM) for women with preterm labor. The present study sets out to analyze stress/anxiety reduction, patient satisfaction and patient's working alliance in a group of 58 women with preterm labor participating in an online psychological stress management project. As part of the project, women were randomly assigned to online stress management or a control condition...
January 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/26692543/why-are-we-waiting-to-start-large-scale-clinical-testing-of-human-chorionic-gonadotropin-for-the-treatment-of-preterm-births
#8
C V Rao
Preterm births are an expensive global health problem. Despite the basic science and clinical research advances to better understand and prevent preterm births, the rates are increasing. There are several therapeutic options. While some options such as progestins work for selected women, others such as magnesium sulfate can only be used for delaying births for 24 to 48 hours so that the patients can be treated with corticosteroids to promote fetal lung maturity. Based on the scientific and clinical evidence, we recommend testing human chorionic gonadotropin in a large multicenter, randomized, double-blind, and placebo-controlled clinical trials in women with active preterm labor and those with a previous history of preterm births...
July 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26554936/post-hoc-analysis-of-vitamin-d-status-and-reduced-risk-of-preterm-birth-in-two-vitamin-d-pregnancy-cohorts-compared-with-south-carolina-march-of-dimes-2009-2011-rates
#9
COMPARATIVE STUDY
C L Wagner, C Baggerly, S McDonnell, K A Baggerly, C B French, L Baggerly, S A Hamilton, B W Hollis
BACKGROUND: Two vitamin D pregnancy supplementation trials were recently undertaken in South Carolina: The NICHD (n=346) and Thrasher Research Fund (TRF, n=163) studies. The findings suggest increased dosages of supplemental vitamin D were associated with improved health outcomes of both mother and newborn, including risk of preterm birth (<37 weeks gestation). How that risk was associated with 25(OH)D serum concentration, a better indicator of vitamin D status than dosage, by race/ethnic group and the potential impact in the community was not previously explored...
January 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26413312/proteomic-network-analysis-of-human-uterine-smooth-muscle-in-pregnancy-labor-and-preterm-labor
#10
Craig Ulrich, David R Quilici, Karen A Schlauch, Iain L O Buxton
The molecular mechanisms involved in human uterine quiescence during gestation and the induction of labor at term or preterm are not completely known. Preterm delivery is associated with major morbidity and mortality and current efforts to prevent delivery until term are largely ineffective. Identification and semi-quantification of proteomic changes in uterine smooth muscle during pregnancy will allow for targeted research into how quiescence is maintained and what changes are associated with induction of labor...
August 2015: Integrative Molecular Medicine
https://www.readbyqxmd.com/read/26411389/-preterm-breech-before-35-weeks-of-gestation-what-is-the-influence-of-the-delivery-route-on-neonatal-condition
#11
N Bruey, D Reinbold, C Creveuil, M Dreyfus
OBJECTIVE: The mode of delivery for preterm breech is still controversial, while no randomized study has been completed. The question of a protective effect of cesarean section on neonatal outcome arises. The objective of this study was to compare mortality and neonatal morbidity for children born before 35 weeks of gestation in breech presentation, depending on the route of delivery. METHODS: This was a retrospective study done in University Hospital type 3 over five years, comparing neonatal mortality and different neonatal morbidity criteria for children born between 25 weeks of gestation and 34 weeks+6 days spread into two groups according to their mode of delivery: elective caesarean section before labor and vaginal delivery...
November 2015: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/26304990/novel-noncompetitive-il-1-receptor-biased-ligand-prevents-infection-and-inflammation-induced-preterm-birth
#12
Mathieu Nadeau-Vallée, Christiane Quiniou, Julia Palacios, Xin Hou, Atefeh Erfani, Ankush Madaan, Mélanie Sanchez, Kelycia Leimert, Amarilys Boudreault, François Duhamel, José Carlos Rivera, Tang Zhu, Baraa Noueihed, Sarah A Robertson, Xin Ni, David M Olson, William Lubell, Sylvie Girard, Sylvain Chemtob
Preterm birth (PTB) is firmly linked to inflammation regardless of the presence of infection. Proinflammatory cytokines, including IL-1β, are produced in gestational tissues and can locally upregulate uterine activation proteins. Premature activation of the uterus by inflammation may lead to PTB, and IL-1 has been identified as a key inducer of this condition. However, all currently available IL-1 inhibitors are large molecules that exhibit competitive antagonism properties by inhibiting all IL-1R signaling, including transcription factor NF-κB, which conveys important physiological roles...
October 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/26236681/periodontal-health-awareness-among-gynecologists-in-riyadh-saudi-arabia
#13
Ghousia Rahman, Farah Asa'ad, Mohammad Abdul Baseer
OBJECTIVE: To determine the knowledge of periodontal disease and pregnancy outcomes among the gynecologists practicing in Riyadh, Saudi Arabia. MATERIALS AND METHODS: A cross-sectional survey of 200 randomly chosen gynecologists from Riyadh was carried out by using a structured, self-administered, closed-ended questionnaire. Knowledge of periodontal disease and possible ways of prevention; knowledge of periodontal disease and pregnancy outcomes; and oral self-care attitudes among gynecologists were assessed...
May 2015: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/26234685/-preterm-labor-reproducibility-of-detection-test-of-pamg-1-before-and-after-digital-examination-and-transvaginal-ultrasound-cervical-length
#14
S Werlen, T Raia, A Di Bartolomeo, C Chauleur
OBJECTIVES: With current diagnostic resources, it is impossible to predict if a patient consulting in the obstetrics emergencies with symptoms of preterm labor, preterm delivery or not. A novel test for the detection of time to spontaneous preterm delivery was developed and would predict imminent delivery in 7 or 14 days from the time of testing. The diagnostic performances of detection test of PAMG-1 have been validated before digital examination. However digital examination is usually made in first line...
October 2015: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/26161639/improved-prediction-of-preterm-delivery-using-empirical-mode-decomposition-analysis-of-uterine-electromyography-signals
#15
Peng Ren, Shuxia Yao, Jingxuan Li, Pedro A Valdes-Sosa, Keith M Kendrick
Preterm delivery increases the risk of infant mortality and morbidity, and therefore developing reliable methods for predicting its likelihood are of great importance. Previous work using uterine electromyography (EMG) recordings has shown that they may provide a promising and objective way for predicting risk of preterm delivery. However, to date attempts at utilizing computational approaches to achieve sufficient predictive confidence, in terms of area under the curve (AUC) values, have not achieved the high discrimination accuracy that a clinical application requires...
2015: PloS One
https://www.readbyqxmd.com/read/26084194/nonreceipt-of-antenatal-magnesium-sulphate-for-fetal-neuroprotection-at-the-women-s-and-children-s-hospital-adelaide-2010-2013
#16
Kasia Siwicki, Emily Bain, Tanya Bubner, Pat Ashwood, Philippa Middleton, Caroline A Crowther
BACKGROUND: Australian and New Zealand clinical practice guidelines, endorsed by the NHMRC in 2010, recommend administration of antenatal magnesium sulphate to women at risk of imminent preterm birth at less than 30 weeks' gestation to reduce the risk of their very preterm babies dying or having cerebral palsy. The purpose of the ongoing Working to Improve Survival and Health for babies born very preterm (WISH) implementation project is to monitor and improve the uptake of this neuroprotective therapy across Australia and New Zealand...
June 2015: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26029118/human-cervicovaginal-fluid-biomarkers-to-predict-term-and-preterm-labor
#17
REVIEW
Yujing J Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan K W Di Quinzio, Harry M Georgiou
Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The current generation of biomarkers predictive of PTB have limited utility. In pregnancy, the human cervicovaginal fluid (CVF) proteome is a reflection of the local biochemical milieu and is influenced by the physical changes occurring in the vagina, cervix and adjacent overlying fetal membranes. Term and preterm labor (PTL) share common pathways of cervical ripening, myometrial activation and fetal membranes rupture leading to birth...
2015: Frontiers in Physiology
https://www.readbyqxmd.com/read/25984349/the-icelandic-16-electrode-electrohysterogram-database
#18
Asgeir Alexandersson, Thora Steingrimsdottir, Jeremy Terrien, Catherine Marque, Brynjar Karlsson
External recordings of the electrohysterogram (EHG) can provide new knowledge on uterine electrical activity associated with contractions. Better understanding of the mechanisms underlying labor can contribute to preventing preterm birth which is the main cause of mortality and morbidity in newborns. Promising results using the EHG for labor prediction and other uses in obstetric care are the drivers of this work. This paper presents a database of 122 4-by-4 electrode EHG recordings performed on 45 pregnant women using a standardized recording protocol and a placement guide system...
2015: Scientific Data
https://www.readbyqxmd.com/read/25672372/perinatal-risk-factors-for-future-sle-a-population-based-nested-case-control-study
#19
E V Arkema, J F Simard
OBJECTIVE: To investigate the association between perinatal characteristics and the offspring's risk of lupus using population-based registers in Sweden. METHODS: We conducted a nested case-control study, identifying systemic lupus erythematosus (SLE) cases from the National Patient Register and controls sampled from the general population matched on birth year, sex, and residential county. We obtained data on the mother's health and age during pregnancy and characteristics of labor and delivery from the Medical Birth Register (births from 1973 through 2008) for cases and controls...
July 2015: Lupus
https://www.readbyqxmd.com/read/25646672/becn1-corpus-luteum-function-and-preterm-labor
#20
Thomas R Gawriluk, Edmund B Rucker
Progesterone is a steroid hormone that is necessary to maintain pregnancy in mammals. We recently found that mice with a conditional deletion of Becn1/Beclin 1 specifically in the progesterone-synthesizing cells of the corpus luteum, had reduced progesterone synthesis and these mice failed to maintain pregnancy.(1) Furthermore, we identified that lipid storage and feedback through PRLR (prolactin receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor) were negatively affected by Becn1 deletion...
2015: Autophagy
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